CN111855978B - Animal brain fixing mechanism, experimental device and method - Google Patents
Animal brain fixing mechanism, experimental device and method Download PDFInfo
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- CN111855978B CN111855978B CN202010557943.XA CN202010557943A CN111855978B CN 111855978 B CN111855978 B CN 111855978B CN 202010557943 A CN202010557943 A CN 202010557943A CN 111855978 B CN111855978 B CN 111855978B
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Abstract
The invention relates to an animal brain fixing mechanism, an experimental device and an experimental method, which comprise a bottom box, wherein a support box is arranged in the bottom box, the bottom box wall of the support box and the bottom box wall of the bottom box have a set distance, the top of the bottom box is buckled with a box cover, the bottom box wall and the box cover of the support box are both provided with a plurality of through holes, the bottom box wall of the support box is detachably connected with a fixing piece, and the fixing piece can be fixedly adhered to an animal brain for experiment.
Description
Technical Field
The invention relates to the technical field of medical testing experimental instruments, in particular to an animal brain fixing mechanism, an experimental device and an animal brain fixing method.
Background
The statements herein merely provide background information related to the present disclosure and may not necessarily constitute prior art.
The brain is the most important organ of human body, and the social burden caused by brain-related diseases including various neurological and mental diseases, which exceeds cardiovascular diseases and cancers, accounts for 28%, and is the biggest disease among all diseases. Therefore, intervention and treatment of serious brain diseases are a very important research content in the field of brain technology at present. The continuous and intensive research on the brain has led to an increasing demand for brain clamps for laboratory animals. Meanwhile, in the experimental process, the condition that the brain of the animal is restored to the state in the cranial cavity as much as possible is the experimental condition of each scientific research worker and the attention of each scientific research worker. However, the inventor finds that there is no special animal brain tissue fixing mechanism at present, and the traditional clamping mode is adopted to fix the brain tissue in the experiment, which will cause larger external force influence on the brain tissue, the experimental material will deform and destroy to a certain extent, which affects the experimental result and increases the experimental cost.
Disclosure of Invention
The invention aims to overcome the defects of the prior art and provide the animal brain fixing mechanism which has small influence on animal brain tissues, avoids the influence of the animal brain fixing on experimental results and reduces the experimental cost.
In order to achieve the purpose, the invention adopts the following technical scheme:
in a first aspect, an embodiment of the present invention provides an animal brain fixing mechanism, which includes a bottom box, a tray box is placed in the bottom box, a set distance is provided between a bottom box wall of the tray box and a bottom box wall of the bottom box, a box cover is fastened to the top of the bottom box, a plurality of through holes are formed in both the bottom box wall of the tray box and the box cover, a fixing piece is detachably connected to the bottom box wall of the tray box, and the fixing piece can be fixed to the animal brain for experiments in an adhering manner.
In a second aspect, the embodiment of the invention provides an animal brain experiment device, which comprises a puncture element and the animal brain fixing mechanism.
In a third aspect, embodiments of the present invention provide a method for operating an animal brain fixation mechanism, comprising:
the bottom box wall of the supporting box supports the brain of the experimental animal, and the brain stem part of the brain of the experimental animal is stuck and fixed by using the fixing sheet;
injecting cerebrospinal fluid into the bottom box until the fixed brain of the experimental animal is completely immersed into the cerebrospinal fluid, and fastening the box cover on the bottom box to complete the fixation of the brain of the experimental animal.
The invention has the beneficial effects that:
1. according to the fixing mechanism, the brain tissue material is fixed in a mode of supporting by the supporting box and suspending and adhering cerebrospinal fluid and brain stem, the state of the brain tissue material in an animal body is simulated, the experimental material is effectively fixed, large clamping force does not need to be applied to the brain of the animal for experiment, the brain of the animal cannot deform or damage, and the accuracy of the experimental result is guaranteed.
2. The fixing mechanism can fix the whole experimental animal brain without carrying out slicing or dicing other preparatory operations on the brain tissue, simplifies experimental preparation steps and negative effects of the operations on experimental materials, and ensures the accuracy of experimental results.
3. According to the fixing mechanism, after an experiment is finished, the brain of the animal for the experiment can be directly taken out by using the support box, the operation is convenient, cerebrospinal fluid flows in the bottom box, the treatment of the cerebrospinal fluid is convenient, and the fixing pieces are detachably connected and are convenient to replace.
4. The fixing mechanism using method provided by the invention has the advantages that the cerebrospinal fluid is used for immersing the animal brain, the environment in the cranial cavity is simulated more truly, the brain in the experimental process is kept in the same state in vivo, adverse effects such as internal stress change of tissues, stress reaction of tissues, dehydration reaction and the like caused by separation are avoided, and errors caused by the adverse effects are reduced.
Drawings
The accompanying drawings, which are incorporated in and constitute a part of this application, illustrate embodiments of the application and, together with the description, serve to explain the application and are not intended to limit the application.
FIG. 1 is a schematic view of the overall structure of embodiment 1 of the present invention;
FIG. 2 is a schematic view of the entire internal structure of embodiment 1 of the present invention;
FIG. 3 is an exploded view of the entire structure of example 1 of the present invention;
FIG. 4 is a schematic view of the working state of embodiment 2 of the present invention;
the experimental animal brain puncture needle comprises a bottom box 1, a support box 2, a box cover 3, a fixing piece 4, a first through hole 5, a second through hole 6, a puncture needle 7 and an experimental animal brain 8;
1.1. a first bottom box wall, 1-2, a first side box wall, 1-3, a boss;
2-1, a second bottom box wall, 2-2, a second side box wall, 2-3, a placing groove and 2-4, a fixing hole;
3-1, a top cover plate, and 3-2, a side cover plate;
4-1, a sticking part and 4-2, a fixing part.
Detailed Description
It should be noted that the following detailed description is exemplary and is intended to provide further explanation of the disclosure. Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this application belongs.
It is noted that the terminology used herein is for the purpose of describing particular embodiments only and is not intended to be limiting of example embodiments according to the present application. As used herein, the singular forms "a", "an" and "the" are intended to include the plural forms as well, and it should be understood that when the terms "comprises" and/or "comprising" are used in this specification, they specify the presence of stated features, steps, operations, devices, components, and/or combinations thereof, unless the context clearly indicates otherwise.
For convenience of description, the words "up", "down", "left" and "right" in the present invention, if any, merely indicate correspondence with up, down, left and right directions of the drawings themselves, and do not limit the structure, but merely facilitate the description of the invention and simplify the description, rather than indicate or imply that the referenced device or element must have a particular orientation, be constructed and operated in a particular orientation, and thus should not be construed as limiting the invention.
As introduced by the background art, the existing animal brain experiment adopts a clamping mode to fix the brain, and the influence on the experimental result is large.
In example 1, which is an exemplary embodiment of the present application, as shown in fig. 1 to 3, an animal brain fixing mechanism includes a base case 1, a tray case 2, and a cover case 3.
The bottom box adopts a cubic structure with an open top, and the box cover can be fastened on the bottom box.
In other embodiments, the bottom case may also adopt a cylindrical structure or other structural forms as long as the experimental requirements are met, and preferably, the bottom case adopts a cubic structure.
The bottom box comprises a first bottom box wall 1-1 and a first side box wall 1-2 which is integrally arranged at four edges of the first bottom box wall and is vertical to the first bottom box wall.
The inner side surface of the first bottom box wall is provided with bosses 1-3, and the bosses are used for placing and supporting the support box.
The boss can extend to the first bottom box wall or does not extend to the first bottom box wall, and preferably, the bottom of the boss extends to the first bottom box wall, so that the bearing effect is good, and the larger pressure can be borne.
The support box also adopts a cubic structure with an opening at the top, and can also adopt a cylindrical structure or other structures to be matched with the bottom box.
The tray box comprises a second bottom box wall 2-1 and a second side box wall 2-2 which is integrally arranged at four edges of the second bottom box wall and is vertical to the second bottom box wall.
The tray box is placed on the upper surface of the boss in the bottom box, so that a set distance is formed between the second bottom box wall of the tray box and the first bottom box wall of the bottom box, the set distance is set according to actual needs, and the distance between the top surface of the boss and the first bottom box wall can be controlled through setting.
The second bottom box wall of the support box is in contact with the upper surface of the boss, the outer side surface of the second side box wall is in close contact with the inner side surface of the first side box wall, and the height of the second side box wall is larger than the distance between the top surface of the first side box wall and the top surface of the boss, so that the top surface of the second side box wall is located above the top surface of the first side box wall, and the support box is conveniently taken out from the bottom box.
The lid adopts the open cube structure who sets up in bottom, and it and end box phase-match can the lock joint at end box top, the lid includes that top apron 3-1 and integral type set up the lateral part apron 3-2 in top apron edge, the bottom surface of lateral part apron can contact with the top surface of first lateral part box wall, and its medial surface can contact with the lateral surface laminating of second lateral part box wall, and the thickness of lateral part apron is the same with the thickness of first lateral part box wall, makes the lid lock joint be at end box, and the lateral surface of first lateral part box wall is parallel and level mutually with the lateral surface of lateral part apron.
The top plate cover plate is provided with a plurality of first through holes 5, the second bottom box wall is provided with second through holes 6 corresponding to each first through hole, the corresponding first through holes and the second through holes are coaxially arranged, puncture needles can penetrate through the top cover plate and the second bottom box wall through the first through holes and the second through holes to reach positions between the first bottom box wall and the second bottom box wall, and the puncture needles can keep a vertical state.
In this embodiment, the first through hole and the second through hole are both square holes, and in other embodiments, the first through hole and the second through hole may also be circular holes or holes with other shapes, as long as the first through hole and the second through hole are matched with the puncture needle, so that the puncture needle can pass through the first through hole and the second through hole.
The detachable stationary blade 4 that is connected with on the second bottom box wall of holding in the palm the box, the stationary blade surface can coat the bonding glue, makes stationary blade and experimental animal brain paste fixedly.
The fixing piece can be detachably connected with the second bottom box wall through a bolt, but the bolt is used for screwing operation, and the operation is complex.
In other embodiments, the fixing sheet comprises an adhering part 4-1 with a cubic structure, one side of the adhering part is used for adhering the brain of the experimental animal, the other side of the adhering part is integrally provided with a fixing part 4-2 with a cubic structure, the fixing part is matched with the fixing part, a placing groove 2-3 matched with the adhering part is formed in the second bottom box wall, the adhering part can be placed in the placing groove, a fixing hole 2-4 matched with the fixing part is formed in the bottom groove surface of the placing groove, and the fixing part can be inserted into the fixing hole.
When the fixed piece is connected with the second bottom box wall, the fixed part is only required to be inserted into the fixed hole, and the bottom surface of the pasting part is in contact with the bottom groove surface of the placing groove, so that the fixed piece can be detachably fixed.
In this embodiment, the thickness of portion of pasting is the same with the groove depth of standing groove, and the top surface of stationary blade is the same level with the top surface of second side box wall after the stationary blade is connected.
By adopting the connection mode, when the fixing piece is installed, the fixing part is inserted into the fixing hole from the position above the second side box wall, and when the fixing piece is taken out, the fixing part is ejected out of the fixing hole from the position below the second side box wall, so that the fixing piece is convenient and quick to assemble and disassemble.
In this embodiment, the attaching portion and the fixing portion are coaxially disposed.
In other embodiments, the sticking portion and the fixing portion may also adopt a cylindrical structure or other structural forms, so as to meet experimental requirements.
Example 2:
the embodiment discloses an animal brain experiment device, which comprises a puncture element and the animal brain fixing mechanism in the embodiment 1, wherein the puncture element is just a conventional puncture needle 7, the specific structure of the puncture element is not described in detail, and the puncture needle can penetrate through a top cover plate and a second bottom box wall through a first through hole and a second through hole. The puncture needle can pierce into the brain of the animal for the experiment to carry out the puncture experiment.
Example 3:
the embodiment discloses a working method of the animal brain fixing mechanism in embodiment 1:
as shown in fig. 4, the tray box is placed on the upper surface of the boss inside the bottom box, the fixing sheet is connected with the second bottom box wall of the tray box, the adhesive is coated on the upper surface of the fixing sheet, the brain 8 of the experimental animal is placed on the second bottom box wall of the tray box, the brain part of the brain of the experimental animal is fixedly adhered to the fixing sheet, the brain of the experimental animal is supported by the second bottom box wall, and the fixation of the brain of the experimental animal is completed.
And cerebrospinal fluid is injected into the bottom box, flows into the bottom box through the second through hole, and rises until the cerebrum of the experimental animal is completely immersed into the cerebrospinal fluid.
The brain tissue material is fixed by adopting the modes of supporting a box, suspending cerebrospinal fluid and sticking the brain stem, the state of the brain tissue material in an animal body is simulated, the experimental material is effectively fixed, great clamping force is not required to be applied to the experimental animal brain, the animal brain cannot deform and break, and the accuracy of the experimental result is ensured.
In addition, the brain fixing mechanism of the embodiment can conveniently fix the whole animal brain, does not need to carry out other preparatory operations such as slicing or dicing and the like on brain tissues for convenient clamping, and simplifies experimental preparation steps and negative effects of the operations on experimental materials.
And the animal brain is immersed into the cerebrospinal fluid, so that the environment in the cranial cavity is simulated more truly, the brain in the experimental process is kept in the same state in vivo, adverse effects such as internal stress change of tissues, stress reaction of the tissues, dehydration reaction and the like caused by separation are avoided, and errors caused by the effects are reduced.
After cerebrospinal fluid submerges the animal brain completely, with the lid lock joint on end box, can continue to carry out the experiment of animal brain this moment, when carrying out the puncture experiment, pass the pjncture needle through first through-hole and pierce through the lid in the animal brain, and wear out through the second through-hole, setting through first through-hole and second through-hole, the effect of location is played to the needle of piercing needle, avoided leading to the problem that pjncture needle and needle inlet can't align because of sheltering from of animal brain for the experiment, it facilitates to provide convenience for the puncture experiment of brain tissue, the research of brain tissue mechanics performance has been made things convenient for.
After the experiment is finished, the box cover is taken down, the supporting box with the experimental animal brain is taken out from the bottom box, and the cerebrospinal fluid can be completely left in the bottom box, so that the further treatment of the cerebrospinal fluid is facilitated.
The adhesive glue for fixing the biological tissue material usually causes the residue of some tissues and glue solidified objects at the bonding position, and the fixing sheet of the embodiment is detachably connected with the second bottom box wall, so that the cleaning, the replacement and the bonding of the brain tissue experimental material are convenient.
Although the embodiments of the present invention have been described with reference to the accompanying drawings, it is not intended to limit the scope of the present invention, and it should be understood by those skilled in the art that various modifications and variations can be made without inventive efforts by those skilled in the art based on the technical solution of the present invention.
Claims (9)
1. The animal brain fixing mechanism is characterized by comprising a bottom box, a support box is arranged in the bottom box, a set distance is reserved between the bottom box wall of the support box and the bottom box wall of the bottom box, a box cover is buckled at the top of the bottom box, the box cover is provided with a plurality of first through holes, the bottom box wall of the support box is provided with second through holes which respectively correspond to the first through holes, the corresponding first through holes and the second through holes are coaxially arranged, the bottom box wall of the support box is detachably connected with a fixing piece which can be stuck and fixed with the brain of the experimental animal, injecting cerebrospinal fluid into the bottom box, allowing the cerebrospinal fluid to flow into the bottom box through the second through hole, allowing the liquid level of the cerebrospinal fluid to rise until the cerebrum of the experimental animal is completely immersed into the cerebrospinal fluid, the brain tissue material is fixed by adopting the modes of supporting by a supporting box, suspending cerebrospinal fluid and sticking brain stem, and the state of the animal brain in the animal body is simulated.
2. The animal brain fixing mechanism as claimed in claim 1, wherein the inner side of the lateral box wall of the bottom box is provided with a boss, the tray is placed on the upper surface of the boss, and the outer side of the lateral box wall of the tray is in close contact with the inner side of the lateral box wall of the bottom box.
3. The animal brain fixing mechanism according to claim 2, wherein the height of the side box wall of the tray box is larger than the distance between the top surface of the side box wall of the bottom box and the top surface of the boss.
4. The animal brain fixing mechanism of claim 3, wherein the box cover comprises a top cover plate and a side cover plate arranged at the edge of the top cover plate, and the bottom surface of the side cover plate can be contacted with the top surface of the side box wall of the bottom box and can be closely contacted with the outer side surface of the side box wall of the holding box.
5. The animal brain fixation mechanism of claim 1, wherein said through hole is a square hole.
6. The animal brain fixing mechanism according to claim 1, wherein the fixing piece comprises an adhesive part and a fixing part disposed on the bottom surface of the adhesive part, the bottom wall of the tray is provided with a placement groove matching with the adhesive part, the bottom surface of the placement groove is provided with a fixing hole matching with the fixing part, the fixing part can be inserted into the fixing hole, the bottom surface of the adhesive part contacts with the groove surface of the placement groove, and the depth of the placement groove is equal to the thickness of the adhesive part.
7. An animal brain experiment device, which is characterized by comprising a puncture element and the animal brain fixing mechanism of any one of claims 1 to 6.
8. The animal brain experiment device according to claim 7, wherein the puncture element is a puncture needle matched with the through hole.
9. A method of operating an animal brain fixation mechanism as claimed in any one of claims 1 to 6, wherein:
the bottom box wall of the supporting box supports the brain of the experimental animal, and the brain stem part of the brain of the experimental animal is stuck and fixed by using the fixing sheet;
injecting cerebrospinal fluid into the bottom box until the fixed brain of the experimental animal is completely immersed into the cerebrospinal fluid, and fastening the box cover on the bottom box to complete the fixation of the brain of the experimental animal.
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| Application Number | Priority Date | Filing Date | Title |
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| CN202010557943.XA CN111855978B (en) | 2020-06-18 | 2020-06-18 | Animal brain fixing mechanism, experimental device and method |
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| Application Number | Priority Date | Filing Date | Title |
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| CN202010557943.XA CN111855978B (en) | 2020-06-18 | 2020-06-18 | Animal brain fixing mechanism, experimental device and method |
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| CN111855978A CN111855978A (en) | 2020-10-30 |
| CN111855978B true CN111855978B (en) | 2021-11-26 |
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| CN107843474A (en) * | 2017-12-12 | 2018-03-27 | 深圳市药品检验研究院（深圳市医疗器械检测中心） | Sample fixing device and animal mucous membrane tissue Slide processing |
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| CN207923484U (en) * | 2018-03-20 | 2018-09-28 | 南昌德漫多科技有限公司 | A kind of sampling device of histopathology sample |
| CN207937238U (en) * | 2018-03-25 | 2018-10-02 | 杨江辉 | A kind of medical ESD Pathologic specimens fixed bin |
| CN209778893U (en) * | 2019-01-29 | 2019-12-13 | 付琰 | Cell culture device capable of fixing biological membrane |
| CN209901310U (en) * | 2019-04-18 | 2020-01-07 | 上海市东方医院（同济大学附属东方医院） | Puncture specimen collecting box |
| CN210417435U (en) * | 2019-08-30 | 2020-04-28 | 刘红丽 | Postoperative tumor specimen disease family members looks over box |
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- 2020-06-18 CN CN202010557943.XA patent/CN111855978B/en active Active
Patent Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN207242506U (en) * | 2017-10-11 | 2018-04-17 | 西安交通大学医学院第一附属医院 | Pathologic specimen conserving case |
| CN107843474A (en) * | 2017-12-12 | 2018-03-27 | 深圳市药品检验研究院（深圳市医疗器械检测中心） | Sample fixing device and animal mucous membrane tissue Slide processing |
| CN207923484U (en) * | 2018-03-20 | 2018-09-28 | 南昌德漫多科技有限公司 | A kind of sampling device of histopathology sample |
| CN207937238U (en) * | 2018-03-25 | 2018-10-02 | 杨江辉 | A kind of medical ESD Pathologic specimens fixed bin |
| CN108318310A (en) * | 2018-05-14 | 2018-07-24 | 上海交通大学医学院附属第九人民医院 | A kind of lower device for the parallel irregular biological tissue of cutting of laser scanning guiding |
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| CN210417435U (en) * | 2019-08-30 | 2020-04-28 | 刘红丽 | Postoperative tumor specimen disease family members looks over box |
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| CN111855978A (en) | 2020-10-30 |
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