CN111840664A - Medical material and method for preparing anticoagulant coating on surface of medical material - Google Patents
Medical material and method for preparing anticoagulant coating on surface of medical material Download PDFInfo
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- CN111840664A CN111840664A CN202010798353.6A CN202010798353A CN111840664A CN 111840664 A CN111840664 A CN 111840664A CN 202010798353 A CN202010798353 A CN 202010798353A CN 111840664 A CN111840664 A CN 111840664A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L33/00—Antithrombogenic treatment of surgical articles, e.g. sutures, catheters, prostheses, or of articles for the manipulation or conditioning of blood; Materials for such treatment
- A61L33/06—Use of macromolecular materials
- A61L33/12—Polypeptides, proteins or derivatives thereof, e.g. degradation products thereof
- A61L33/128—Other specific proteins or polypeptides not covered by A61L33/122 - A61L33/126
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L33/00—Antithrombogenic treatment of surgical articles, e.g. sutures, catheters, prostheses, or of articles for the manipulation or conditioning of blood; Materials for such treatment
- A61L33/0005—Use of materials characterised by their function or physical properties
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L33/00—Antithrombogenic treatment of surgical articles, e.g. sutures, catheters, prostheses, or of articles for the manipulation or conditioning of blood; Materials for such treatment
- A61L33/0005—Use of materials characterised by their function or physical properties
- A61L33/0011—Anticoagulant, e.g. heparin, platelet aggregation inhibitor, fibrinolytic agent, other than enzymes, attached to the substrate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L33/00—Antithrombogenic treatment of surgical articles, e.g. sutures, catheters, prostheses, or of articles for the manipulation or conditioning of blood; Materials for such treatment
- A61L33/06—Use of macromolecular materials
- A61L33/08—Polysaccharides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
- A61L2300/252—Polypeptides, proteins, e.g. glycoproteins, lipoproteins, cytokines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/42—Anti-thrombotic agents, anticoagulants, anti-platelet agents
Abstract
The invention provides a medical material and a method for preparing an anticoagulant coating on the surface of the medical material, belonging to the field of medical instruments. The invention adds the procedure of processing the medical material, can guarantee the cleanness of the medical material, and further guarantee the coating adhesion degree, and meanwhile, the invention has simple process and easy operation, and the prepared anticoagulant coating medical material can guarantee the medical effect.
Description
Technical Field
The invention belongs to the technical field of medical instruments, and particularly relates to a medical material and a method for preparing an anticoagulant coating on the surface of the medical material.
Background
Medical device products, such as vascular stents, extracorporeal blood circulation pumps, intravenous indwelling tubes, artificial blood vessels and the like, are easy to stimulate the blood coagulation mechanism and form thrombus when being clinically applied, and the use safety of the devices is seriously affected. The simple and efficient heparin coating technology on the surface of the medical material is developed, the blood compatibility and the anticoagulation performance of the medical material are promoted, and the occurrence of thrombus of medical products can be reduced to a great extent, so that the treatment effect is guaranteed. At present, heparin anticoagulant coating technology of medical materials is being widely developed and applied.
In the prior art, O.Larm et al report that the surface of a material is subjected to strong acid oxidation to form active groups capable of being grafted, and heparin molecules are finally grafted onto the surface of the material in a covalent bond form through multi-step treatment. The method is a heparin coating method which is widely applied at present and has better anticoagulation activity, long-term stability and the like.
However, the existing medical material and the method for preparing the anticoagulant coating on the surface of the medical material have the problems that the adhesion degree of the coating is easily influenced due to the unclean treatment of the medical material, the processing process flow is complicated, and the medical effect is poor.
Therefore, it is necessary to invent a medical material and a method for preparing an anticoagulant coating on the surface of the medical material.
Disclosure of Invention
In order to solve the technical problems, the invention provides a medical material and a method for preparing an anticoagulant coating on the surface of the medical material, and aims to solve the problems that the adhesion degree of the coating is easily influenced due to unclean medical material treatment, the processing process flow is complicated and the medical effect is poor in the conventional medical material and the method for preparing the anticoagulant coating on the surface of the medical material, wherein the method for preparing the anticoagulant coating on the surface of the medical material specifically comprises the following steps:
the method comprises the following steps: preparing medical materials, namely preparing the medical materials, preparing raw materials according to medical requirements, processing the raw materials by medical processing equipment to prepare the medical materials, placing the processed and prepared medical materials in a sterilizing chamber for sterilizing, refrigerating and storing the medical materials in a refrigerating chamber, marking the medical materials, and visually inspecting the medical materials for later use;
step two: the preparation of the anticoagulant coating comprises the following steps:
the first step is as follows: preparing MES buffer solution;
the second step is that: preparing a solution, preparing a sodium hyaluronate solution with the concentration of 2mg/ml to 25mg/ml, preparing a hirudin solution with the concentration of 2mg/ml to 15mg/ml, and mixing the two solutions to prepare a mixed solution;
the third step: treating the mixed solution, namely adding a cross-linking agent into the mixed solution, uniformly mixing to ensure that hirudin and sodium hyaluronate are covalently cross-linked, and mixing with the mixed solution added with the cross-linking agent through a MES buffer solution to prepare an anticoagulant coating;
step three: the surface cleaning of the medical material is carried out according to the following steps:
the first step is as follows: treating the medical material, namely taking out the refrigerated medical material, placing the refrigerated medical material at room temperature for standing, removing condensate, removing impurities and dust, flushing the medical material by medical disinfectant, and then ventilating and airing for later use;
the second step is that: preparing medical material visual inspection, namely manually inspecting the processed medical material to check whether the processed medical material is damaged or not, removing unqualified medical material, temporarily storing the qualified medical material on a stainless steel frame, inspecting the surface condition of the medical material by touching with a hand after the visual inspection, removing redundant bulges or burrs, and finally performing secondary visual inspection, and storing for later use;
step four: the anticoagulant coating treatment of the medical material comprises the following specific steps:
the first step is as follows: stirring the anticoagulant coating, namely stirring the prepared anticoagulant coating, stirring the prepared anticoagulant coating through a stirring rod, filtering the mixture through a filter screen, collecting the mixture through an immersion cylinder, and placing the immersion cylinder at room temperature to remove impurities for later use;
the second step is that: dip-coating the medical material, namely immersing the medical material in an immersion cylinder, determining the immersion time, immersing more than three medical materials at one time at intervals, taking out the medical material, placing the medical material on a stainless steel bracket, collecting the dripping anticoagulation coating liquid, and performing secondary immersion according to the inspection condition;
the third step: after the medical material is prepared, airing and standing, placing the immersed medical material on a stainless steel bracket for airing, placing the immersed medical material in a sealed transparent dustproof glass box, and treating the medical material in a natural airing way;
step five: the preparation and detection of the anticoagulant coating medical material, namely, the qualified anticoagulant coating medical material is inspected through manual visual inspection to check the material processing condition, the qualified anticoagulant coating medical material is placed in a disinfection box for storage and disinfection after being qualified, secondary visual inspection is carried out, and the qualified anticoagulant coating medical material is sealed, stored and labeled;
step six: the material can be used for medical use according to medical requirements.
Preferably, in the step one, the sterilization is performed by using an ultraviolet sterilization method.
Preferably, in the second step, the mass ratio of hirudin to sodium hyaluronate in the second step is 1: 1 to 1: 10.
preferably, in the third step, the room temperature in the first step is set to be 20-25 ℃, and the standing time is set to be 20-30 min.
Preferably, in the third step, the medical disinfectant in the first step is a disinfectant with an alcohol content of 75%.
Preferably, in the fourth step, the stirring reaction temperature in the first step is set to 55-65 ℃, and the stirring reaction time is set to 5-7 hours.
Preferably, in step four, the spacing interval in the second step is 2-4 mm.
Preferably, in step four, the immersion time in the second step is set to 15-20 min.
Preferably, in the fourth step, the airing and standing time in the third step is set to be 25-35 min.
The invention adopts another technical scheme to solve the technical problems and provides a medical material, wherein the surface of the medical material is provided with an anticoagulant coating, and the anticoagulant coating is prepared by the method.
Compared with the prior art, the invention has the following beneficial effects: the medical material and the method for preparing the anticoagulant coating on the surface of the medical material are widely applied to the technical field of medical instruments. The invention adds the procedure of processing the medical material, can guarantee the cleanness of the medical material, and then guarantee the coating adhesion degree, meanwhile, the invention has simple process and easy operation, and the prepared anticoagulant coating medical material can guarantee the medical effect; the invention covalently combines the anticoagulant factor hirudin with small molecular weight and stable anticoagulant effect with the sodium hyaluronate gel network with good biocompatibility, thereby solving the technical problems of unstable or non-long anticoagulant effect and poor biocompatibility of the existing anticoagulant coating material.
Drawings
FIG. 1 is a flow chart of a medical material and a method for preparing an anticoagulant coating on the surface of the medical material.
FIG. 2 is a flow chart of anticoagulant coating preparation.
Fig. 3 is a flow chart of surface cleaning of medical materials.
Fig. 4 is a flow chart of a medical material anticoagulant coating process.
Detailed Description
The invention is further described below with reference to the accompanying drawings:
in the figure:
as shown in figure 1
The method for preparing the anticoagulant coating on the surface of the medical material specifically comprises the following steps:
s101: preparing medical materials, namely preparing the medical materials, preparing raw materials according to medical requirements, processing the raw materials by medical processing equipment to prepare the medical materials, placing the processed and prepared medical materials in a sterilizing chamber for sterilizing, refrigerating and storing the medical materials in a refrigerating chamber, marking the medical materials, and visually inspecting the medical materials for later use;
s102: the preparation of the anticoagulant coating is shown in the attached figure 2, and the specific operation is carried out according to the following steps:
s201: preparing MES buffer solution;
s202: preparing a solution, preparing a sodium hyaluronate solution with the concentration of 2mg/ml to 25mg/ml, preparing a hirudin solution with the concentration of 2mg/ml to 15mg/ml, and mixing the two solutions to prepare a mixed solution;
s203: treating the mixed solution, namely adding a cross-linking agent into the mixed solution, uniformly mixing to ensure that hirudin and sodium hyaluronate are covalently cross-linked, and mixing with the mixed solution added with the cross-linking agent through a MES buffer solution to prepare an anticoagulant coating;
s103: the surface cleaning of the medical material, as shown in the attached figure 3, should be carried out according to the following steps:
s301: treating the medical material, namely taking out the refrigerated medical material, placing the refrigerated medical material at room temperature for standing, removing condensate, removing impurities and dust, flushing the medical material by medical disinfectant, and then ventilating and airing for later use;
s302: preparing medical material visual inspection, namely manually inspecting the processed medical material to check whether the processed medical material is damaged or not, removing unqualified medical material, temporarily storing the qualified medical material on a stainless steel frame, inspecting the surface condition of the medical material by touching with a hand after the visual inspection, removing redundant bulges or burrs, and finally performing secondary visual inspection, and storing for later use;
s104: the anticoagulant coating treatment of the medical material is carried out according to the following steps as shown in the attached figure 4:
s401: stirring the anticoagulant coating, namely stirring the prepared anticoagulant coating, stirring the prepared anticoagulant coating through a stirring rod, filtering the mixture through a filter screen, collecting the mixture through an immersion cylinder, and placing the immersion cylinder at room temperature to remove impurities for later use;
s402: dip-coating the medical material, namely immersing the medical material in an immersion cylinder, determining the immersion time, immersing more than three medical materials at one time at intervals, taking out the medical material, placing the medical material on a stainless steel bracket, collecting the dripping anticoagulation coating liquid, and performing secondary immersion according to the inspection condition;
s403: after the medical material is prepared, airing and standing, placing the immersed medical material on a stainless steel bracket for airing, placing the immersed medical material in a sealed transparent dustproof glass box, and treating the medical material in a natural airing way;
s105: the preparation and detection of the anticoagulant coating medical material, namely, the qualified anticoagulant coating medical material is inspected through manual visual inspection to check the material processing condition, the qualified anticoagulant coating medical material is placed in a disinfection box for storage and disinfection after being qualified, secondary visual inspection is carried out, and the qualified anticoagulant coating medical material is sealed, stored and labeled;
s106: the material can be used for medical use according to medical requirements.
Preferably, in S101, the sterilization is performed by using an ultraviolet sterilization method.
Preferably, in S102, the mass ratio of hirudin to sodium hyaluronate in S202 is 1: 1 to 1: 10.
preferably, in S103, the room temperature in S301 is set to 20 to 25 ℃, and the standing time is set to 20 to 30 min.
Preferably, in S103, the medical disinfecting solution in S301 is a disinfecting solution with an alcohol content of 75%.
Preferably, in S104, the stirring reaction temperature in S401 is set to 55-65 ℃, and the stirring reaction time is set to 5-7 hours.
Preferably, in S104, the spacing interval in S402 is 2-4 mm.
Preferably, in S104, the immersion time in S402 is set to 15-20 min.
Preferably, in S104, the airing rest time in S403 is set to be 25-35 min.
The invention adopts another technical scheme to solve the technical problems and provides a medical material, wherein the surface of the medical material is provided with an anticoagulant coating, and the anticoagulant coating is prepared by the method.
Detailed description of the preferred embodiment
1. Preparing medical materials, namely preparing the medical materials, preparing raw materials according to medical requirements, processing the raw materials by medical processing equipment to prepare the medical materials, placing the processed and prepared medical materials in a sterilizing chamber for sterilizing, refrigerating and storing the medical materials in a refrigerating chamber, marking the medical materials, and visually inspecting the medical materials for later use;
2. the preparation of the anticoagulant coating comprises the following steps:
the first step is as follows: preparing MES buffer solution;
the second step is that: preparing a solution, preparing a sodium hyaluronate solution with the concentration of 2mg/ml to 25mg/ml, preparing a hirudin solution with the concentration of 2mg/ml to 15mg/ml, and mixing the two solutions to prepare a mixed solution;
the third step: treating the mixed solution, namely adding a cross-linking agent into the mixed solution, uniformly mixing to ensure that hirudin and sodium hyaluronate are covalently cross-linked, and mixing with the mixed solution added with the cross-linking agent through a MES buffer solution to prepare an anticoagulant coating;
3. the surface cleaning of the medical material is carried out according to the following steps:
the first step is as follows: treating the medical material, namely taking out the refrigerated medical material, placing the refrigerated medical material at room temperature for standing, removing condensate, removing impurities and dust, flushing the medical material by medical disinfectant, and then ventilating and airing for later use;
the second step is that: preparing medical material visual inspection, namely manually inspecting the processed medical material to check whether the processed medical material is damaged or not, removing unqualified medical material, temporarily storing the qualified medical material on a stainless steel frame, inspecting the surface condition of the medical material by touching with a hand after the visual inspection, removing redundant bulges or burrs, and finally performing secondary visual inspection, and storing for later use;
4. the anticoagulant coating treatment of the medical material comprises the following specific steps:
the first step is as follows: stirring the anticoagulant coating, namely stirring the prepared anticoagulant coating, stirring the prepared anticoagulant coating through a stirring rod, filtering the mixture through a filter screen, collecting the mixture through an immersion cylinder, and placing the immersion cylinder at room temperature to remove impurities for later use;
the second step is that: dip-coating the medical material, namely immersing the medical material in an immersion cylinder, determining the immersion time, immersing more than three medical materials at one time at intervals, taking out the medical material, placing the medical material on a stainless steel bracket, collecting the dripping anticoagulation coating liquid, and performing secondary immersion according to the inspection condition;
the third step: after the medical material is prepared, airing and standing, placing the immersed medical material on a stainless steel bracket for airing, placing the immersed medical material in a sealed transparent dustproof glass box, and treating the medical material in a natural airing way;
5. the preparation and detection of the anticoagulant coating medical material, namely, the qualified anticoagulant coating medical material is inspected through manual visual inspection to check the material processing condition, the qualified anticoagulant coating medical material is placed in a disinfection box for storage and disinfection after being qualified, secondary visual inspection is carried out, and the qualified anticoagulant coating medical material is sealed, stored and labeled;
6. the material can be used for medical use according to medical requirements.
The invention adds the procedure of processing the medical material, can guarantee the cleanness of the medical material, and further guarantee the coating adhesion degree, and meanwhile, the invention has simple process and easy operation, and the prepared anticoagulant coating medical material can guarantee the medical effect.
The technical solutions of the present invention or similar technical solutions designed by those skilled in the art based on the teachings of the technical solutions of the present invention are all within the scope of the present invention.
Claims (10)
1. The method for preparing the anticoagulant coating on the surface of the medical material is characterized by comprising the following steps of:
the method comprises the following steps: preparing medical materials, namely preparing the medical materials, preparing raw materials according to medical requirements, processing the raw materials by medical processing equipment to prepare the medical materials, placing the processed and prepared medical materials in a sterilizing chamber for sterilizing, refrigerating and storing the medical materials in a refrigerating chamber, marking the medical materials, and visually inspecting the medical materials for later use;
step two: preparing an anticoagulant coating;
step three: cleaning the surface of the medical material;
step four: treating the anticoagulant coating of the medical material;
step five: the preparation and detection of the anticoagulant coating medical material, namely, the qualified anticoagulant coating medical material is inspected through manual visual inspection to check the material processing condition, the qualified anticoagulant coating medical material is placed in a disinfection box for storage and disinfection after being qualified, secondary visual inspection is carried out, and the qualified anticoagulant coating medical material is sealed, stored and labeled;
step six: the material can be used for medical use according to medical requirements.
2. The method for preparing the anticoagulant coating on the surface of the medical material according to claim 1, wherein in the second step, the anticoagulant coating is prepared according to the following steps:
the first step is as follows: preparing MES buffer solution;
the second step is that: preparing a solution, preparing a sodium hyaluronate solution with the concentration of 2mg/ml to 25mg/ml, preparing a hirudin solution with the concentration of 2mg/ml to 15mg/ml, and mixing the two solutions to prepare a mixed solution;
the third step: and (3) treating the mixed solution, namely adding a cross-linking agent into the mixed solution, uniformly mixing to ensure that hirudin and sodium hyaluronate are covalently cross-linked, and mixing with the mixed solution added with the cross-linking agent through a MES buffer solution to prepare the anticoagulant coating.
3. The method for preparing the anticoagulant coating on the surface of the medical material according to claim 1, wherein in the third step, the surface of the medical material is cleaned according to the following steps:
the first step is as follows: treating the medical material, namely taking out the refrigerated medical material, placing the refrigerated medical material at room temperature for standing, removing condensate, removing impurities and dust, flushing the medical material by medical disinfectant, and then ventilating and airing for later use;
the second step is that: the medical material looks examines and prepares, looks through the manual work with the medical material that handles and examines, whether the inspection has damage or is defective, gets rid of unqualified medical material to place qualified medical material in and keep in on the stainless steel frame, look examine the back and touch through the hand, inspect medical material surface condition, get rid of unnecessary arch or burr, carry out the secondary at last and look and examine, after accomplishing, store for subsequent use.
4. The method for preparing the anticoagulant coating on the surface of the medical material according to claim 1, wherein in the fourth step, the anticoagulant coating treatment of the medical material is performed according to the following steps:
the first step is as follows: stirring the anticoagulant coating, namely stirring the prepared anticoagulant coating, stirring the prepared anticoagulant coating through a stirring rod, filtering the mixture through a filter screen, collecting the mixture through an immersion cylinder, and placing the immersion cylinder at room temperature to remove impurities for later use;
the second step is that: dip-coating the medical material, namely immersing the medical material in an immersion cylinder, determining the immersion time, immersing more than three medical materials at one time at intervals, taking out the medical material, placing the medical material on a stainless steel bracket, collecting the dripping anticoagulation coating liquid, and performing secondary immersion according to the inspection condition;
the third step: and (3) airing and standing the medical material after preparation, airing the immersed medical material on a stainless steel bracket, placing the medical material in a sealed transparent dustproof glass box, and treating the medical material in a natural airing way.
5. The method for preparing an anticoagulant coating on the surface of a medical material according to claim 1, wherein in the step one, the sterilization is performed by using an ultraviolet sterilization method.
6. The method for preparing an anticoagulant coating on the surface of a medical material according to claim 2, wherein in the second step, the mass ratio of hirudin to sodium hyaluronate in the second step is 1: 1 to 1: 10.
7. the method for preparing an anticoagulant coating on the surface of a medical material according to claim 3, wherein the room temperature in the first step is set to be 20-25 ℃ and the standing time is set to be 20-30min in the third step.
8. The method for preparing anticoagulant coating on the surface of medical material according to claim 3, wherein in step three, the medical disinfecting liquid in the first step is a disinfecting liquid with 75% alcohol content.
9. The method for preparing an anticoagulant coating on the surface of medical material according to claim 4, wherein in the fourth step, the stirring reaction temperature in the first step is set to 55-65 ℃, and the stirring reaction time is set to 5-7 hours.
10. The method for preparing an anticoagulant coating on the surface of a medical material according to claim 4, wherein in step four, the interval in the second step is 2-4 mm.
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| CN202010798353.6A CN111840664A (en) | 2020-08-11 | 2020-08-11 | Medical material and method for preparing anticoagulant coating on surface of medical material |
| CN202011434031.XA CN112274707A (en) | 2020-08-11 | 2020-12-10 | Medical material and method for preparing anticoagulant coating on surface of medical material |
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| CN112843331A (en) * | 2021-01-04 | 2021-05-28 | 山东迈尔医疗科技有限公司 | Preparation method of composite coating on surface of titanium alloy dental implant |
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| US20030161938A1 (en) * | 2002-02-22 | 2003-08-28 | Bo Johnson | Composition and method for coating medical devices |
| CN103721300B (en) * | 2013-12-19 | 2015-05-20 | 华中科技大学 | Anticoagulation coating material and preparation method thereof |
| CN109498839A (en) * | 2018-11-13 | 2019-03-22 | 南开大学 | A kind of biology composite artificial blood vessel and application |
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| CN112843331A (en) * | 2021-01-04 | 2021-05-28 | 山东迈尔医疗科技有限公司 | Preparation method of composite coating on surface of titanium alloy dental implant |
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Application publication date: 20201030 |