CN1034673A - With the hydrogen peroxide steam former method of reducing phlegm and internal heat - Google Patents
With the hydrogen peroxide steam former method of reducing phlegm and internal heat Download PDFInfo
- Publication number
- CN1034673A CN1034673A CN 88109172 CN88109172A CN1034673A CN 1034673 A CN1034673 A CN 1034673A CN 88109172 CN88109172 CN 88109172 CN 88109172 A CN88109172 A CN 88109172A CN 1034673 A CN1034673 A CN 1034673A
- Authority
- CN
- China
- Prior art keywords
- internal heat
- hydrogen peroxide
- former
- phlegm
- assembly time
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
- A61L2/16—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor using chemical substances
- A61L2/20—Gaseous substances, e.g. vapours
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Apparatus For Disinfection Or Sterilisation (AREA)
Abstract
The invention provides a kind of surface former method of reducing phlegm and internal heat.This method is included in to be lower than and exposes various surface a period of times in about 100 ℃ certain density hydrogen peroxide steam, and it is former to be enough to during this period of time to be reduced phlegm and internal heat in these surfaces.Open-assembly time also can be to be enough to make simultaneously surface sterilizing and to reduce phlegm and internal heat former.
Description
Former (depyrogenation) method that the present invention relates to reduce phlegm and internal heat more particularly, the present invention relates to a kind of method of using hydrogen peroxide steam to remove pyrogen.
Endotoxin is the high molecular weight component relevant with gram negative bacteria.When decomposing bacteria, can discharge all endotoxins.The sterilization sterilization always can not removed endotoxin effectively or be made it inactivation.No matter the inactivation method is removed or is made it in employing, all eliminates the calorigenic effect of endotoxin or pyrogen the non-intestinal injection that must use from patients or the water.In addition, must eliminate fully basically will with various goods such as medical apparatus and instruments, various liquid bottle and the lip-deep pyrogenic effect of piping of contact patients.
There is several method can reach the sterilization and the former purpose of reducing phlegm and internal heat simultaneously.Dry heating method is effectively for sterilizing and reduce phlegm and internal heat former, but it needs about 250 ℃ temperature, and this temperature is can not be received to the thermally labile goods.
For a long time, people's known in which hydrogen peroxide has the former ability of reducing phlegm and internal heat.Nineteen forty-seven, A.Taub and F.Hart have delivered the paper of exercise question for " hydrogen peroxide to some injection on the American Pharmacopeia in the detoxification of pyrogen " on American Pharmaceutical Association's will (1948).This paper has been described and a kind of various solution has been boiled the method for removing pyrogen with low concentration hydrogen peroxide.Show that hydrogen peroxide is a kind ofly effectively to reduce phlegm and internal heat former dose for blood plasma substitute oxypolygelatin and sodium chloride solution and glucose solution.Referring to Cherkin " immunochemistry " 12: " hydrogen peroxide is to the destruction of bacterial endotoxin pyrogenicity " delivered 625(1975).Recently, the United States Patent (USP) 4 that people such as Makinen announced on March 10th, 1987, described a kind of continuous preparation method aseptic, pyrogen-free solution in 648,978, this method is simultaneously solution to be sterilized and reduced phlegm and internal heat former with liquid hydrogen peroxide or ozone and heating means.
It is former and other method that can not sterilize comprises only to reduce phlegm and internal heat: heat treated, with the basic hydrolysis of appropriate acetic acid or appropriateness, rupture with oxidizer treatment, acetylation, hydroxyl amino decomposition and with lithium aluminium hydride reduction.The some of them method is satisfied to simple solution only.
The goods and the surface of solids do not resemble solution, and it can not always sterilize or reduce phlegm and internal heat former by liquid hydrogen peroxide in conjunction with heating means.Show, can carry out the sterilization of product surface effectively in the method that is lower than use hydrogen peroxide steam under 80 ℃ of temperature.Referring to people's United States Patent (USP)s 4,169,124 such as people's United States Patent (USP)s such as Moore 4,169,123 and Forstrom.There is not patent to propose to reduce phlegm and internal heat former problem.
An object of the present invention is to provide a kind ofly to the various surfaces former method of reducing phlegm and internal heat, it does not rely on dry heating method and boils the hydrogen peroxide desired high temperature of former method that reduces phlegm and internal heat.Another object of the present invention provides a kind ofly sterilizes simultaneously to various surfaces under the desired temperature conditions of art methods and reduces phlegm and internal heat former method being lower than relatively.
The invention provides a kind of surface former method of reducing phlegm and internal heat, this method is exactly these surfaces to be exposed to be lower than about 100 ℃, certain density hydrogen peroxide steam a period of time, is enough to reach the surface during this period of time and reduces phlegm and internal heat former.Best, be enough to reach simultaneously surface sterilizing during this period of time and reduce phlegm and internal heat former.This method also comprise the former back of reducing phlegm and internal heat with the gas blow-washing surface to remove the hydrogen peroxide of any absorption.
Open-assembly time can be less than or equal 24 hours and concentration may be up to about 2 mg/litre.Perhaps, open-assembly time can be less than about 30 minutes and concentration may be up to 10 mg/litre.
The inventive method use is lower than about 100 ℃, preferably about 50-70 ℃ hydrogen peroxide steam carries out surface sterilization simultaneously and reduces phlegm and internal heat former.Usually, this method comprises the hydrogen peroxide steam a period of time that various product surfaces is exposed to be lower than 100 ℃, should be enough to reach the surface during this period of time and reduce phlegm and internal heat former.Hydrogen peroxide steam concentration is preferably lower than or equals about 10 mg/litre.
Hydrogen peroxide steam concentration is along with the variations in temperature of using.Temperature is high more, and the concentration of hydrogen peroxide that may reside in relevant air space is big more.For example when room temperature (about 20 ℃), concentration can be 2 mg/litre.In the time of 55 ℃, concentration can be 10 mg/litre.Bigger hydrogen peroxide steam concentration has caused reducing phlegm and internal heat faster former, therefore needs short open-assembly time.Following two embodiment explanation, low concentration needs long open-assembly time.
Embodiment 1
With endotoxin dry preparation sample on the surface of 316 rustless steel probe tubes, make the dosage that contains 2200 endotoxin units on 1 sq.The 30% hydrogenperoxide steam generator top that this sample is suspended in 55 ℃ of temperature is located 24 hours for about 2 inches.Detecting the vapour concentration that contacts with sample is 1.9 mg/litre.Limulus amebocyte lysate (LAL) measurement result shows, has both made under the condition than ideal conditions difference, and 99.97% endotoxin inactivation is also arranged.The be far from condition expected in most of practical applications of the present invention of the condition of embodiment 1 is perfect.So open-assembly time is than long in the open-assembly time of more improving under the condition usually.
Embodiment 2
To there be the sample of the endotoxic 316 rustless steel probe tubes of various dose to be exposed in 55 ℃ of phase hydrogen peroxide bactericidal units under the temperature 25 minutes in its dry tack free.The hydrogen peroxide steam Cmax reaches 10 mg/litre in the steriliser.Yet disinfecting action does not have to use the necessary means of keeping biocide concentration in the steriliser.After disinfecting action was finished, LAL the analysis showed that, had when beginning that endotoxic activity has reduced 90.8% in the sample of 6500 endotoxin unit dosage, and activity of endotoxin has reduced 87.2% in another samples of 90,000 endotoxin unit dosage and have during beginning.
Endotoxin destructive can be selectively than high percent by increasing open-assembly time or concentration of hydrogen peroxide or increasing open-assembly time simultaneously and concentration of hydrogen peroxide reaches.Temperature in the former process of reducing phlegm and internal heat must remain in the scope of not damaging the former goods that reduced phlegm and internal heat.Best scope is about 50-80 ℃.Be higher than 80 ℃ but to be lower than about 100 ℃ temperature and to be lower than 50 ℃ temperature also can be effective.
Method of the present invention also can comprise may be by any hydrogen peroxide of these adsorptions to remove with the surface of gas blow-washing goods.
Phase hydrogen peroxide is particularly advantageous for reducing phlegm and internal heat former, because it can use under relatively low temperature and lower concentration. In addition, it can be sterilized to handled surface simultaneously. Have the propensity that is degraded into water and oxygen after hydrogen peroxide steam is long-time, in fact this eliminated chemical method removing (needed in hydrogen peroxide liquid the is reduced phlegm and internal heat origin operation) pollution of former dose of used very harmful material to goods of reducing phlegm and internal heat.
Various goods can be encapsulated in the permeable goods packing container of any hydrogen peroxide steam to prevent from exposing post-job recontamination.
Claims (6)
1, a kind of surface former method of reducing phlegm and internal heat is included in to be lower than and exposes various surface a period of times in about 100 ℃ certain density hydrogen peroxide steam, and it is former that open-assembly time is enough to be reduced phlegm and internal heat in described surface.
2, according to the process of claim 1 wherein that described concentration is less than or equal to about 10 mg/litre.
3, according to the process of claim 1 wherein that described open-assembly time is enough to make described surface to sterilize simultaneously and reduce phlegm and internal heat former.
4, according to the process of claim 1 wherein that described open-assembly time is less than or equals 24 hours, described concentration is up to 2 mg/litre.
5, according to the process of claim 1 wherein that described open-assembly time is less than about 30 minutes, described concentration is less than or equal to 10 mg/litre.
6, comprise also that according to the process of claim 1 wherein the former back of reducing phlegm and internal heat is with the described surface of gas blow-washing, to remove residual hydrogen peroxide.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US13999287A | 1987-12-30 | 1987-12-30 | |
| US139,992 | 1987-12-30 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1034673A true CN1034673A (en) | 1989-08-16 |
Family
ID=22489232
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 88109172 Pending CN1034673A (en) | 1987-12-30 | 1988-12-30 | With the hydrogen peroxide steam former method of reducing phlegm and internal heat |
Country Status (2)
| Country | Link |
|---|---|
| CN (1) | CN1034673A (en) |
| WO (1) | WO1989006121A1 (en) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5652006A (en) * | 1992-10-09 | 1997-07-29 | Unilever Patent Holdings B.V. | Method of heat processing foodstuff |
| US5785934A (en) * | 1995-01-06 | 1998-07-28 | Johnson & Johnson Medical, Inc. | Vapor sterilization using inorganic hydrogen peroxide complexes |
| CN111781366A (en) * | 2020-07-24 | 2020-10-16 | 褚培忠 | Method for detecting endotoxin in hydrogen peroxide solution |
| CN115414531B (en) * | 2022-09-20 | 2024-06-04 | 上海亚朋生物技术有限公司 | Method for removing fat and endotoxin from allogeneic bone |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4169123A (en) * | 1975-12-11 | 1979-09-25 | Moore-Perk Corporation | Hydrogen peroxide vapor sterilization method |
| DE3134050A1 (en) * | 1981-08-28 | 1983-03-10 | Dr. Franz Köhler Chemie GmbH, 6146 Alsbach | Solution for sterilising and removing pyrogens from stainless steel lines and filters in a closed system |
-
1988
- 1988-12-16 WO PCT/US1988/004506 patent/WO1989006121A1/en unknown
- 1988-12-30 CN CN 88109172 patent/CN1034673A/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| WO1989006121A1 (en) | 1989-07-13 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US4648978A (en) | Process for the continuous preparation of sterile, depyrogenated solutions | |
| EP1094847B1 (en) | A method for disinfecting and sterilizing microbial contaminated materials | |
| AU610613B2 (en) | Low pressure hydrogen peroxide vapor sterilization system | |
| WO2005000364B1 (en) | Sterilization methods and apparatus which employ additive-containing supercritical carbon dioxide sterilant | |
| WO2012003962A1 (en) | Use of a sterilization agent for enhancing hemocompatibility | |
| CN1519033A (en) | Method of steriling package material | |
| CN1034673A (en) | With the hydrogen peroxide steam former method of reducing phlegm and internal heat | |
| CN110917422B (en) | Ultrapure hemodialysis concentrated solution and preparation process thereof | |
| JP6590395B2 (en) | Gas nitrogen oxide generation method, generator and recovery method | |
| JPH0214116B2 (en) | ||
| Penna et al. | Cleaning of blood-contaminated reprocessed angiographic catheters and spinal needles | |
| JP2006095308A (en) | Low temperature disinfection and sterilization method and its apparatus | |
| JPH04189728A (en) | Dry sterilization and sterile air supply method | |
| JP2003522000A (en) | Sterilization of medical instruments | |
| US3257161A (en) | Potentiation of biocidal activity of epoxides | |
| CN218870901U (en) | Pipeline disinfection device of breathing machine | |
| Guyomard et al. | Effects of ionizing radiations on bacterial endotoxins: comparison between gamma radiations and accelerated electrons | |
| CN112791199B (en) | Irradiation sterilization method of hemodialyzer | |
| JPS5819259A (en) | Pasturization of medical tool | |
| US20060275172A1 (en) | Item reprocessing and sterile packaging apparatus | |
| JPS6247355A (en) | Apparatus for supplying ozone air and ozone water to dental treatment stand | |
| JP2714660B2 (en) | Dental sterilizer | |
| CN116077693A (en) | Ward mattress disinfection device for medical care | |
| Estahbanati | Advances in Vaporized Hydrogen Peroxide Reusable Medical Device Sterilization Cycle Development: Technology Review and Patent Trends | |
| RU93016567A (en) | METHOD OF STERILIZING MEDICAL INSTRUMENTS |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C01 | Deemed withdrawal of patent application (patent law 1993) | ||
| WD01 | Invention patent application deemed withdrawn after publication |