CN111840457A - Liuhe antireflecting granule and preparation method thereof - Google Patents
Liuhe antireflecting granule and preparation method thereof Download PDFInfo
- Publication number
- CN111840457A CN111840457A CN202010711842.3A CN202010711842A CN111840457A CN 111840457 A CN111840457 A CN 111840457A CN 202010711842 A CN202010711842 A CN 202010711842A CN 111840457 A CN111840457 A CN 111840457A
- Authority
- CN
- China
- Prior art keywords
- liuhe
- rhizoma
- granules
- vinegar
- decoction
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
- A61K36/8967—Lilium, e.g. tiger lily or Easter lily
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/285—Aucklandia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/54—Lauraceae (Laurel family), e.g. cinnamon or sassafras
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/66—Papaveraceae (Poppy family), e.g. bloodroot
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
- A61K36/718—Coptis (goldthread)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
- A61K36/752—Citrus, e.g. lime, orange or lemon
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
- A61K36/754—Evodia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/89—Cyperaceae (Sedge family)
- A61K36/8905—Cyperus (flatsedge)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
Abstract
The invention provides Liuhe Zhi Fang granules and a preparation method thereof, wherein the Liuhe Zhi Fang granules comprise the following components in parts by weight: 600g of lily, 200g of combined spicebush root, 200g of costustoot, 300g of vinegar-processed rhizoma corydalis, 300g of rhizoma cyperi, 180g of coptis root, 60g of fructus evodiae and 240g of fructus aurantii, and the invention also provides a preparation method of the Liuhe Zhi Chong granules, which comprises the following steps: the method comprises the following steps: s1): adding 5 times of water into radix Linderae, radix aucklandiae, rhizoma Cyperi and fructus Aurantii, distilling for 3 hr, receiving distillate, standing, taking out volatile oil layer, and filtering the distilled water solution to obtain filtrate and residue; s2): mixing the residues, Bulbus Lilii, rhizoma corydalis processed with vinegar, Coptidis rhizoma and fructus evodiae, adding 8 times of water, decocting for three times, filtering, mixing filtrates, and standing overnight; s3): taking out the supernatant of the combined filtrate; the Liuhe anti-regurgitation granules have obvious clinical effect on liver and stomach stagnated heat type esophagus reflux esophagitis, have no relapse after medicine stopping, have no side effect and are convenient to popularize and use.
Description
Technical Field
The invention relates to the technical field of traditional Chinese medicines, in particular to Liuhe Zhi Fang granules and a preparation method thereof.
Background
Reflux esophagitis is a common clinical manifestation of gastroesophageal reflux disease, symptoms or tissue damage caused by reflux of stomach or duodenum contents into esophagus is caused, the clinical manifestations mainly include acid regurgitation, heartburn and poststernal pain, severe patients have dysphagia, main medicines for treating reflux esophagitis in western medicine currently take various Proton Pump Inhibitors (PPIs) as mainstream, although the clinical effects are quick and the acid-making effect is good, the medicines need to be taken for a long time and cannot be cured radically, the treatment cost is high, the economic burden of patients is heavy, and if the medicines are continuously used for a long time, potential risk factors which cannot be ignored are presented, and researches show that: the PPI can affect the biological barrier of the intestinal tract by changing the normal flora of the intestinal tract, so that the risk of intestinal infection is increased, the PPI can cause the absorption of calcium ions to be obstructed, high gastrin disease caused by the use of the PPI can cause intestinal epithelioid cell-like carcinoid tumors, and the traditional Chinese medicine for treating the reflux esophagitis has good clinical curative effect with high effective rate and low recurrence rate, however, at present, no traditional Chinese medicine preparation for treating the reflux esophagitis is available in China, only the soup is used for auxiliary treatment, the use is inconvenient, and the popularization is limited to a certain extent.
Disclosure of Invention
The technical problem to be solved by the invention is to overcome the existing defects and provide Liuhe Zhi Fang granules and a preparation method thereof, and the Liuhe Zhi Fang granules have obvious clinical effect on liver and stomach stagnated heat type esophageal reflux esophagitis, have no relapse after medicine stopping, have no side effect, are convenient to popularize and use, and can effectively solve the problems in the background technology.
In order to achieve the above object, the present invention proposes: the six-in-one antipodal particle comprises the following components in parts by weight: 600g of lily, 200g of combined spicebush root, 200g of costustoot, 300g of vinegar-processed rhizoma corydalis, 300g of rhizoma cyperi, 180g of coptis chinensis, 60g of fructus evodiae and 240g of fructus aurantii.
The invention also provides a preparation method of the Liuhe antipodal particles, which comprises the following steps: the method comprises the following steps:
s1): adding 5 times of water into radix Linderae, radix aucklandiae, rhizoma Cyperi and fructus Aurantii, distilling for 3 hr, receiving distillate, standing, taking out volatile oil layer, and filtering the distilled water solution to obtain filtrate and residue;
s2): mixing the residues, Bulbus Lilii, rhizoma corydalis processed with vinegar, Coptidis rhizoma and fructus evodiae, adding 8 times of water, decocting for three times, filtering, mixing filtrates, and standing overnight;
s3): taking out supernatant of the combined filtrate, and concentrating to obtain extract with relative density of 1.32-1.35, and maintaining the temperature at 60 deg.C;
s4): adding appropriate amount of soluble starch and 10g aspartame into the extract, granulating the obtained product, drying, spraying volatile oil, mixing thoroughly to obtain 1000g of finished product, and packaging the finished product with low density polyethylene medicinal polymeric membrane to obtain Liuhe Zhi Fang granule.
As a preferred technical scheme of the invention: the time of the first decoction is 1.5 hours, the time of the second decoction is 1 hour, the time of the third decoction is 1 hour, and the time of the second decoction is 1 hour, so that the condition that the ointment yield is too high and granulation cannot be carried out can be avoided.
As a preferred technical scheme of the invention: the temperature of the supernatant fluid is 80 ℃ when the supernatant fluid is concentrated under reduced pressure, the pressure is-0.06 Mpa to-0.08 Mpa, and the extraction damage amount of the alkaloid in the water is minimum when the supernatant fluid is concentrated under reduced pressure.
Compared with the prior art, the invention has the beneficial effects that:
1. the combined spicebush root has the effects of promoting qi circulation, relieving pain, warming kidney and dispelling cold, the lily has the effects of relieving phlegm and cough, nourishing yin and moistening lung, the costustoot has the effects of promoting qi circulation, relieving pain, strengthening spleen and helping digestion, the corydalis tuber prepared by vinegar has the effects of promoting blood circulation, promoting qi circulation and relieving pain, the rhizoma cyperi has the effects of soothing liver and relieving depression, regulating menstruation and relieving pain, the coptis has the effects of clearing heat, drying dampness, purging fire and detoxifying, the fructus evodiae has the effects of dispelling cold, relieving pain, calming the adverse-rising energy, preventing vomiting, supporting yang and relieving diarrhea, the fructus aurantii has the effects of regulating qi, relieving depression and relieving distension, eight traditional Chinese medicines are used as raw;
2. the Liuhe Zhi Chong granules are prepared from pure traditional Chinese medicines, can relieve the pain of a patient caused by a long-term proton pump antacid, have remarkable clinical curative effect, have no relapse after stopping taking the medicine, can also lighten the economic burden of the patient, ensure the quality stability and controllability of product production by taking the Liuhe Zhi Chong granules in a form of medicament granules, are convenient for large-scale production and popularization, and accord with the trend of economic and social development.
Drawings
FIG. 1 is a flow chart of the process for preparing the six-membered antipodal particle of the present invention.
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
Referring to fig. 1, the present invention provides the following technical solutions:
the first embodiment is as follows:
the six-in-one antipodal particle comprises the following components in parts by weight: the six-medicine granule for preventing the reflux disease is prepared from the eight traditional Chinese medicines of 600g of lily, 200g of combined spicebush root, 200g of costustoot, 300g of vinegar-processed rhizoma corydalis, 300g of rhizoma cyperi, 180g of coptis chinensis, 60g of fructus evodiae and 240g of fructus aurantii, does not contain any additive, cannot cause harm to the body of a patient, and has obvious curative effect on patients with reflux esophagitis symptoms.
The invention also provides a preparation method of the Liuhe antipodal particles, which comprises the following steps: the method comprises the following steps:
s1): adding 5 times of water into the combined spicebush root, the costustoot, the nutgrass galingale rhizome and the bitter orange, distilling for 3 hours, receiving distillate, standing, taking out a volatile oil layer for later use, filtering a distilled water solution to obtain filtrate and dregs, and obtaining the filtrate and the dregs through sad study of adding water, wherein the amount of volatile oil obtained by selecting 5 times and 6 times of water amount is basically equivalent to that of volatile oil obtained by selecting 5 times and 6 times of water amount and is higher than that obtained by adding 4 times of water amount, and the distillation time is known from practice, and the distillation efficiency is basically equivalent to that of 4 hours at 3 hours, so the distillation is selected for 3;
s2): mixing the herb residues, lily, vinegar-processed rhizoma corydalis, coptis and fructus evodiae, adding 8 times of water, decocting for three times, wherein the first decoction time is 1.5 hours, and the second and third decoction times are both 1 hour, then filtering, combining the filtrates, and standing overnight, wherein tests show that when the three times of decoction are extracted for 1.5 hours, the ointment yield is too high, and granulation cannot be carried out, so that the first decoction time is 1.5 hours, and the second and third decoction times are 1 hour;
s3): taking out the supernatant of the combined filtrate, and concentrating to obtain an extract with a relative density of 1.32, wherein the temperature is kept at 60 ℃, the temperature of the supernatant during vacuum concentration is 80 ℃, the pressure is-0.06 Mpa, the damage of the vacuum concentration to the extraction amount of the alkaloid in the water is minimum, and the time required by the vacuum concentration is short;
s4): adding a proper amount of soluble starch and 10g of aspartame into the extract, granulating the obtained product, drying, spraying volatile oil, fully and uniformly mixing to prepare 1000g of finished product, packaging the finished product by using a low-density polyethylene medicinal polymeric film to obtain Liuhe Zhi Fang granules, and uniformly mixing the soluble starch and 10g of aspartame during granulation to obtain the prepared granules with better moisture resistance, moderate hardness and good solubility.
Example two:
the six-in-one antipodal particle comprises the following components in parts by weight: 600g of lily, 200g of combined spicebush root, 200g of costustoot, 300g of vinegar-processed rhizoma corydalis, 300g of rhizoma cyperi, 180g of coptis chinensis, 60g of fructus evodiae and 240g of fructus aurantii.
The invention also provides a preparation method of the Liuhe antipodal particles, which comprises the following steps: the method comprises the following steps:
s1): adding 5 times of water into radix Linderae, radix aucklandiae, rhizoma Cyperi and fructus Aurantii, distilling for 3 hr, receiving distillate, standing, taking out volatile oil layer, and filtering the distilled water solution to obtain filtrate and residue;
s2): mixing the residues, lily, vinegar-processed rhizoma corydalis, coptis and fructus evodiae, adding 8 times of water, decocting for three times, wherein the first decoction time is 1.5 hours, and the second and third decoction times are both 1 hour, filtering, combining the filtrates, and standing overnight;
s3): taking out supernatant of the combined filtrate, and concentrating to obtain extract with relative density of 1.34, maintaining temperature at 60 deg.C, and concentrating supernatant under reduced pressure at 80 deg.C and-0.07 Mpa;
s4): adding appropriate amount of soluble starch and 10g aspartame into the extract, granulating the obtained product, drying, spraying volatile oil, mixing thoroughly to obtain 1000g of finished product, and packaging the finished product with low density polyethylene medicinal polymeric membrane to obtain Liuhe Zhi Fang granule.
Example three:
the six-in-one antipodal particle comprises the following components in parts by weight: 600g of lily, 200g of combined spicebush root, 200g of costustoot, 300g of vinegar-processed rhizoma corydalis, 300g of rhizoma cyperi, 180g of coptis chinensis, 60g of fructus evodiae and 240g of fructus aurantii.
The invention also provides a preparation method of the Liuhe antipodal particles, which comprises the following steps: the method comprises the following steps:
s1): adding 5 times of water into radix Linderae, radix aucklandiae, rhizoma Cyperi and fructus Aurantii, distilling for 3 hr, receiving distillate, standing, taking out volatile oil layer, and filtering the distilled water solution to obtain filtrate and residue;
s2): mixing the residues, lily, vinegar-processed rhizoma corydalis, coptis and fructus evodiae, adding 8 times of water, decocting for three times, wherein the first decoction time is 1.5 hours, and the second and third decoction times are both 1 hour, filtering, combining the filtrates, and standing overnight;
s3): taking out supernatant of the combined filtrate, and concentrating to obtain extract with relative density of 1.35, maintaining temperature at 60 deg.C, and concentrating supernatant under reduced pressure at 80 deg.C and-0.08 Mpa;
s4): adding appropriate amount of soluble starch and 10g aspartame into the extract, granulating the obtained product, drying, spraying volatile oil, mixing thoroughly to obtain 1000g of finished product, and packaging the finished product with low density polyethylene medicinal polymeric membrane to obtain Liuhe Zhi Fang granule.
Clinical observation data of the Liuhe Zhi Fang granule:
the six-joint antipruritic granule has the advantages that the study on 60 patients, 30 men and 30 women, the average age of 48.38 +/-12.52 years old, no allergic history or family history of 60 patients, no other related treatment and no combined medication, the average medication time is 27.47 days, 9 patients are clinically cured in 60 patients, 23 patients have obvious effects, the cure rate is 53.33, 23 patients have effective effects, the cure rate is 15%, the significant effect rate is 38.33%, the effective rate is 38.33%, the ineffective rate is 8.33%, the total effective rate is 91.67%, the six-joint antipruritic granule has better curative effects on liver-stomach stagnated heat syndrome patients with gastroesophageal reflux disease in traditional Chinese medicine, and the individual symptoms of 60 patients before and after medication comprise heartburn, poststernal pain, acid regurgitation, food regurgitation and the like are improved in different degrees, adverse reactions of 60 patients before and after treatment are recorded, indexes of electrocardiogram, liver and kidney functions and the like of the patients before and after treatment have no obvious difference, and no adverse reaction occurs in 60 cases within a normal range.
Clinical data show that the Liuhe Zhi Chong granules can effectively improve clinical symptoms of patients with liver and stomach stagnated heat type reflux esophagitis, have no adverse reaction after administration, have low recurrence rate, can relieve the pain of the patients and improve the life quality, and the Liuhe Jia Yu decoction (agreement prescription) has definite curative effect on treating the liver and stomach stagnated heat type reflux esophagitis, is safe, has no toxic or side reaction, and is worthy of further clinical popularization and application.
The invention has the advantages that: the Liuhe Zhi Chong granule is mainly used for treating reflux esophagitis, replaces traditional western medicine treatment medicines, overcomes the defect that a proton pump inhibitor easily damages a human body, has remarkable clinical treatment effect, does not have repetition after stopping medicine, can reduce the long-term economic burden and mental burden of a patient, is more convenient to popularize compared with a decoction treatment method, has good treatment stability and controllability, and has important significance for treating reflux esophagitis diseases.
Although embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that changes, modifications, substitutions and alterations can be made in these embodiments without departing from the principles and spirit of the invention, the scope of which is defined in the appended claims and their equivalents.
Claims (4)
1. Six-in-one anti-reflecting particle is characterized in that: the six-component antipodal granules comprise the following components in parts by weight: 600g of lily, 200g of combined spicebush root, 200g of costustoot, 300g of vinegar-processed rhizoma corydalis, 300g of rhizoma cyperi, 180g of coptis chinensis, 60g of fructus evodiae and 240g of fructus aurantii.
2. The preparation method of the Liuhe antipodal particles is characterized by comprising the following steps: the method comprises the following steps:
s1): adding 5 times of water into radix Linderae, radix aucklandiae, rhizoma Cyperi and fructus Aurantii, distilling for 3 hr, receiving distillate, standing, taking out volatile oil layer, and filtering the distilled water solution to obtain filtrate and residue;
s2): mixing the residues, Bulbus Lilii, rhizoma corydalis processed with vinegar, Coptidis rhizoma and fructus evodiae, adding 8 times of water, decocting for three times, filtering, mixing filtrates, and standing overnight;
s3): taking out supernatant of the combined filtrate, and concentrating to obtain extract with relative density of 1.32-1.35, and maintaining the temperature at 60 deg.C;
s4): adding appropriate amount of soluble starch and 10g aspartame into the extract, granulating the obtained product, drying, spraying volatile oil, mixing thoroughly to obtain 1000g of finished product, and packaging the finished product with low density polyethylene medicinal polymeric membrane to obtain Liuhe Zhi Fang granule.
3. The method for preparing a hexa-dentate antiparticulate according to claim 2, wherein: the time of the first decoction is 1.5 hours, and the time of the second decoction and the time of the third decoction are both 1 hour.
4. The method for preparing a hexa-dentate antiparticulate according to claim 2, wherein: the temperature of the supernatant fluid is 80 ℃ and the pressure is between-0.06 Mpa and-0.08 Mpa when the supernatant fluid is decompressed and concentrated.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202010711842.3A CN111840457A (en) | 2020-07-22 | 2020-07-22 | Liuhe antireflecting granule and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202010711842.3A CN111840457A (en) | 2020-07-22 | 2020-07-22 | Liuhe antireflecting granule and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN111840457A true CN111840457A (en) | 2020-10-30 |
Family
ID=72949205
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202010711842.3A Pending CN111840457A (en) | 2020-07-22 | 2020-07-22 | Liuhe antireflecting granule and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN111840457A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN116270489A (en) * | 2023-03-22 | 2023-06-23 | 遵义市中医院 | Ginger stomach-activating granule and preparation method thereof |
-
2020
- 2020-07-22 CN CN202010711842.3A patent/CN111840457A/en active Pending
Non-Patent Citations (1)
| Title |
|---|
| 唐玲等: "六合加萸汤治疗肝胃郁热型反流性食管炎经验体会", 《贵阳中医学院学报》 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN116270489A (en) * | 2023-03-22 | 2023-06-23 | 遵义市中医院 | Ginger stomach-activating granule and preparation method thereof |
| CN116270489B (en) * | 2023-03-22 | 2023-09-08 | 遵义市中医院 | Ginger stomach-activating granule and preparation method thereof |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN111840457A (en) | Liuhe antireflecting granule and preparation method thereof | |
| CN111514274A (en) | Traditional Chinese medicine composition for treating reflux esophagitis and preparation method and application thereof | |
| CN107362331B (en) | Traditional Chinese medicine composition and preparation method and application thereof | |
| CN104721445A (en) | Traditional Chinese medicine ointment for treating bedsores and preparation method thereof | |
| CN114377095A (en) | Fructus amomi-sandalwood volatile oil extraction method, capsule for treating gastritis and preparation method of capsule | |
| CN101327293B (en) | Capsules for treating peptic ulcer and preparation method thereof | |
| CN106983795A (en) | Chinese medicine composition with antitumor activity and its preparation method and application | |
| CN104257846A (en) | Traditional Chinese medicine composition for preventing edema disease and preparation method thereof | |
| CN107213386A (en) | A kind of Chinese medicine composition and preparation method and application | |
| CN112107668A (en) | Traditional Chinese medicine for treating gastric precancerous lesion | |
| CN104524359B (en) | A kind of Chinese medicine composition, its preparation method and application | |
| CN110934980B (en) | Traditional Chinese medicine formula and application thereof | |
| CN102526628B (en) | Medicinal composition for treating myocardial infarction | |
| CN100423764C (en) | Tumor-treating oral Chinese medicine composition | |
| CN105477246A (en) | Traditional Chinese medicine composition for treating phlegmatic hygrosis type mammary gland hyperplasia and preparation method thereof | |
| CN112641884A (en) | Composition for repairing gastric mucosa and improving gastric motility and preparation method thereof | |
| CN106619730B (en) | Medicine for treating hepatitis A and preparation method thereof | |
| CN106177438B (en) | A kind of Chinese medicine composition for treating kidney and preparation method thereof | |
| CN106620641A (en) | Composition containing fermented soybean protein powder and purpose thereof | |
| CN113769018A (en) | Traditional Chinese medicine composition for treating gout and preparation method thereof | |
| CN104435497A (en) | Traditional Chinese medicinal composition for treating diabetic feet | |
| CN112336844A (en) | Traditional Chinese medicine prescription for navel therapy, Du moxibustion and indirect moxibustion | |
| CN114869987A (en) | A Chinese medicinal composition for preventing and treating hepatocarcinoma | |
| CN115671249A (en) | Traditional Chinese medicine mixture for treating gastroesophageal reflux disease | |
| CN113975366A (en) | Four-processed hypoglycemic coptis composition and production processing method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20201030 |
|
| RJ01 | Rejection of invention patent application after publication |