CN111821273A - Production method of aspirin enteric-coated tablets and powder adding device - Google Patents
Production method of aspirin enteric-coated tablets and powder adding device Download PDFInfo
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
- A61K9/2833—Organic macromolecular compounds
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- A—HUMAN NECESSITIES
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- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
- A61J3/06—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of pills, lozenges or dragees
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/60—Salicylic acid; Derivatives thereof
- A61K31/612—Salicylic acid; Derivatives thereof having the hydroxy group in position 2 esterified, e.g. salicylsulfuric acid
- A61K31/616—Salicylic acid; Derivatives thereof having the hydroxy group in position 2 esterified, e.g. salicylsulfuric acid by carboxylic acids, e.g. acetylsalicylic acid
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- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
- A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
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- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin
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- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2095—Tabletting processes; Dosage units made by direct compression of powders or specially processed granules, by eliminating solvents, by melt-extrusion, by injection molding, by 3D printing
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- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65G—TRANSPORT OR STORAGE DEVICES, e.g. CONVEYORS FOR LOADING OR TIPPING, SHOP CONVEYOR SYSTEMS OR PNEUMATIC TUBE CONVEYORS
- B65G65/00—Loading or unloading
- B65G65/30—Methods or devices for filling or emptying bunkers, hoppers, tanks, or like containers, of interest apart from their use in particular chemical or physical processes or their application in particular machines, e.g. not covered by a single other subclass
- B65G65/34—Emptying devices
- B65G65/40—Devices for emptying otherwise than from the top
- B65G65/44—Devices for emptying otherwise than from the top using reciprocating conveyors, e.g. jigging conveyors
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Abstract
The invention discloses a production method of aspirin enteric-coated tablets, which comprises the following steps: sieving corn starch, crushing cane sugar, and granulating dextrin, the sieved corn starch and the crushed cane sugar to obtain blank particles; respectively weighing aspirin, blank granules and dry corn starch, sequentially putting into a blending barrel, adding the weighed dry corn starch into the blending barrel, and performing total mixing and tabletting on the prepared aspirin, the blank granules and the dry corn starch. The aspirin enteric-coated tablet prepared by mixing the blank particles and aspirin together can effectively prevent aspirin from being heated and external moisture from permeating, prevent aspirin from being hydrolyzed and effectively reduce the content of free salicylic acid; meanwhile, aspirin is prevented from disintegrating in gastric juice, and the disintegrating and dissolving effects of aspirin in intestinal tracts are guaranteed.
Description
Technical Field
The invention relates to the technical field of soluble tablet production, in particular to a production method of aspirin enteric-coated tablets and a powder adding device.
Background
Aspirin is an antipyretic analgesic, has multiple functions, is used for antipyretic analgesia for the first time, and is mainly used for preventing diseases such as thrombus and the like. In addition, aspirin also has the effect of alleviating mucocutaneous lymph node syndrome.
Salicylic acid is the main component of aspirin, is a product obtained by hydrolyzing acetylsalicylic acid, and is also a main component bringing about the side effect of aspirin. Because acetylsalicylic acid is easy to hydrolyze to generate salicylic acid, aspirin tablets in the prior art contain a certain amount of free salicylic acid, when aspirin is taken in a large dose, patients can suffer from headache, dizziness, nausea, vomit, tinnitus, visual hearing loss and the like caused by the salicylic acid taken by the patients, and even serious patients can suffer from the symptoms of confusion, coma and the like.
In the production process of the existing aspirin enteric-coated tablet, a proper amount of water is required to be added for granulation and other processes, so that salicylic acid is generated, most raw materials in the aspirin enteric-coated tablet are powder, the adding weight of the powder is not easy to accurately control during adding, the proportion of the aspirin enteric-coated tablet cannot be well controlled, and the quality of the aspirin enteric-coated tablet is influenced.
Disclosure of Invention
Therefore, the invention provides a production method of an aspirin enteric-coated tablet and a powder adding device, and aims to solve the problems that in the prior art, in the production process of the aspirin enteric-coated tablet, a proper amount of water needs to be added for granulation and other processes, so that salicylic acid is generated, meanwhile, most raw materials in the aspirin enteric-coated tablet are powder, the adding weight of the powder is not easy to accurately control during adding, so that the proportion of the aspirin enteric-coated tablet cannot be well controlled, and the quality of the aspirin enteric-coated tablet is influenced.
In order to achieve the above object, an embodiment of the present invention provides the following:
a production method of aspirin enteric-coated tablets comprises the following steps:
step 100, weighing corn starch, sieving, weighing cane sugar and crushing; mixing the sieved corn starch, the crushed cane sugar and the dextrin according to a prescription; mixing the materials by a mixer and granulating to obtain blank particles;
step 200, weighing corn starch, drying and sieving to obtain dried corn starch with specified granularity;
step 300, respectively weighing aspirin and blank particles, sequentially putting the aspirin and the blank particles into a blending barrel, adding excessive dry corn starch into the blending barrel, and putting the blended aspirin, the blank particles and the dry corn starch into a two-dimensional motion mixer for total mixing;
step 400, after the total mixing, performing primary tabletting through a tabletting machine to obtain a planar tablet, putting the planar tablet into a swing granulator to prepare granules, and putting the granules and excessive dry corn starch into a two-dimensional motion mixer to mix again;
500, tabletting the mixed granules and the dried corn starch by a rotary tablet press to obtain tablet cores;
step 600, dissolving polyacrylic resin II with ethanol, adding castor oil, diethyl phthalate, tween-80 and talcum powder to prepare an enteric coating liquid, coating the tablet core with the enteric coating liquid by using high-efficiency sugar coating and film coating equipment, and drying to obtain a finished product.
As a preferred scheme of the invention, the cane sugar is crushed by a crusher, the corn starch is screened by a 100-mesh screen by a vortex type oscillating screen, and the dextrin is not required to be crushed and screened.
As a preferred embodiment of the present invention, in step 100, the specific steps of granulating dextrin, pulverized corn starch and sucrose to obtain blank granules are as follows:
sequentially mixing dried corn starch, sucrose and dextrin into a barrel according to the formula, and pouring the mixture into a mixing machine for mixing;
adding purified water into the mixed starch, sucrose and dextrin, and mixing for 2-10 minutes to obtain a soft material;
granulating the prepared soft material by using a swing granulator, drying by using a boiling drying box, and granulating the dried material into granules.
The invention also provides a powder adding device for the method, which comprises a powder adding component, the powder adding component comprises a feeding hopper, a material collecting barrel and a material receiving box, the material collecting barrel is arranged in the material receiving box, the output end of the charging hopper is positioned right above the material collecting barrel, the material collecting barrel comprises a base, a cylinder body vertically penetrates through the base, the lower end of the cylinder body is flush with the lower end surface of the base, the lower surface of the base is provided with a cylinder body closing plate for closing the outlet at the lower end of the cylinder body, the top end of the cylinder body is provided with a top flat plate, the upper outlet of the cylinder body is flush with the top flat plate, a horizontal pushing cylinder is arranged in the material receiving box and horizontally fixed on the inner wall of the material receiving box, and the output end of the horizontal pushing cylinder is connected with a horizontal pushing plate, the horizontal pushing plate is right opposite to the cylinder body, and the lower end face of the horizontal pushing plate is flush with the upper surface of the top flat plate.
As a preferable scheme of the present invention, two clamping plates are arranged in parallel on the lower end surface of the base, the clamping plates are L-shaped, a sliding groove is formed between the two clamping plates, the cylinder closing plate is slidably arranged in the sliding groove, the upper end surface of the cylinder closing plate is closely attached to the base, a closing rack is arranged on the lower surface of the cylinder closing plate, a closing motor is arranged on the lower end surface of the base, a closing gear is arranged on an output shaft of the closing motor, the closing gear is engaged with the closing rack, and the closing motor drives the closing gear to rotate so as to enable the cylinder closing plate to slide in the sliding groove, thereby closing the lower end outlet of the cylinder.
As a preferable scheme of the present invention, both ends of the sliding groove are provided with a limiting seat.
As a preferable scheme of the invention, a vertical vibration assembly is arranged in the material receiving box, the vertical vibration assembly comprises an installation seat arranged in the material receiving box, a through hole is arranged at the center of the installation seat, the cylinder body penetrates through the through hole, the top flat plate and the base are respectively positioned at the upper end and the lower end of the installation seat, the cylinder body is not in contact with the through hole, a stretching cylinder is arranged on the lower end face of the top flat plate, the output end of the stretching cylinder is vertically downward and is provided with a permanent magnet, an electromagnetic block is arranged on the upper end face of the installation seat, the permanent magnet is positioned right above the electromagnetic block, a vibration spring is arranged between the top flat plate and the installation seat, and the vibration spring is positioned outside the stretching cylinder.
As a preferable scheme of the present invention, an output end of the stretching cylinder is connected to a vertical guide rod, a lower end of the guide rod passes through the mounting seat, the permanent magnet is annular and disposed on an outer periphery of a top of the guide rod, and the electromagnetic block is annular and sleeved outside the guide rod.
As a preferable scheme of the invention, the lower end of the mounting seat is connected with a mounting cylinder, the lower end of the mounting cylinder penetrates through the material receiving box, the lower end edge of the top flat plate is connected with a side sliding plate, the side sliding plate inclines outwards from top to bottom, and the bottom end of the side sliding plate is positioned on the outer side of the mounting seat.
As a preferable scheme of the invention, a vibration knocking component is further arranged in the material receiving box, the vibration knocking component comprises a vibration knocking base fixed on the inner wall of the material receiving box, a vibration knocking lead screw and a vibration knocking lever are arranged on the vibration knocking base through a support, the vibration knocking lead screw is a reciprocating lead screw and is provided with a lead screw nut seat, the lead screw nut seat is connected with one end of the vibration knocking lever, the other end of the vibration knocking lever is connected with a vibration knocking block, one end of the vibration knocking lead screw is connected with a lead screw motor, and the lead screw motor drives the vibration knocking lead screw to rotate, so that the lead screw nut seat moves on the vibration knocking lead screw to drive the vibration knocking lever to rotate, and the vibration knocking block is knocked on the barrel.
The embodiment of the invention has the following advantages:
the aspirin enteric-coated tablet prepared by mixing the blank particles and aspirin together can effectively prevent aspirin from being heated and external moisture from permeating, prevent aspirin from being hydrolyzed and effectively reduce the content of free salicylic acid;
meanwhile, the powder adding component is used for firstly dropping the powder into the material collecting barrel and then dropping the powder into the mixing equipment through the material collecting barrel, so that the accurate control of the volume can be realized after the powder drops into the material collecting barrel, and then the accurate control of the adding weight of the powder can be realized by utilizing the conversion relation between the volume and the quality of the powder, thereby being beneficial to the accurate proportioning of the enteric-coated tablets and improving the quality of the aspirin enteric-coated tablets.
Drawings
In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings used in the description of the embodiments or the prior art will be briefly described below. It should be apparent that the drawings in the following description are merely exemplary, and that other embodiments can be derived from the drawings provided by those of ordinary skill in the art without inventive effort.
The structures, ratios, sizes, and the like shown in the present specification are only used for matching with the contents disclosed in the specification, so as to be understood and read by those skilled in the art, and are not used to limit the conditions that the present invention can be implemented, so that the present invention has no technical significance, and any structural modifications, changes in the ratio relationship, or adjustments of the sizes, without affecting the effects and the achievable by the present invention, should still fall within the range that the technical contents disclosed in the present invention can cover.
FIG. 1 is a schematic flow chart of a production method of aspirin enteric-coated tablets of the present invention;
FIG. 2 is a schematic diagram of the overall structure of a powder adding device of the aspirin enteric-coated tablet of the present invention;
FIG. 3 is a schematic structural diagram of a vertical vibration component of a powder adding device of an aspirin enteric-coated tablet of the invention;
FIG. 4 is a schematic structural diagram of a barrel closing plate of a powder adding device of aspirin enteric-coated tablets of the invention;
FIG. 5 is a structural diagram of a vibration component of a powder adding device of the aspirin enteric-coated tablet of the present invention;
fig. 6 is an enlarged schematic view of a knocking component of a powder adding device of the aspirin enteric-coated tablet of the invention.
In the figure:
1. a vertical vibration assembly; 2. a knocking component; 3. a hopper; 4. a material collecting barrel; 5. a material receiving box;
101. a mounting seat; 102. perforating; 103. stretching the cylinder; 104. a permanent magnet; 105. an electromagnetic block; 106. a vibration spring; 107. a guide bar; 108. mounting the cylinder; 109. a side slide plate;
201. a knocking base; 202. vibrating the lead screw; 203. a knock lever; 204. a lead screw nut seat; 205. a knock block; 206. a lead screw motor;
401. a base; 402. a barrel; 403. a cylinder closing plate; 404. a top plate; 405. a horizontal pushing cylinder; 406. a flat push plate; 407. a splint; 408. a sliding groove; 409. closing the rack; 410. closing the motor; 411. a closing gear; 412. a limiting seat.
Detailed Description
The present invention is described in terms of particular embodiments, other advantages and features of the invention will become apparent to those skilled in the art from the following disclosure, and it is to be understood that the described embodiments are merely exemplary of the invention and that it is not intended to limit the invention to the particular embodiments disclosed. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
As shown in fig. 1, the embodiment of the present invention provides a method for producing aspirin enteric-coated tablets, comprising the following steps: step 100, weighing corn starch, sieving, weighing cane sugar and crushing; mixing the sieved corn starch, the crushed cane sugar and the dextrin according to a prescription; mixing the materials by a mixer and granulating to obtain blank particles;
step 200, weighing corn starch, drying and sieving to obtain dried corn starch with specified granularity;
step 300, respectively weighing aspirin and blank particles, sequentially putting the aspirin and the blank particles into a blending barrel, adding excessive dry corn starch into the blending barrel, and putting the blended aspirin, the blank particles and the dry corn starch into a two-dimensional motion mixer for total mixing;
step 400, after the total mixing, performing primary tabletting through a tabletting machine to obtain a planar tablet, putting the planar tablet into a swing granulator to prepare granules, and putting the granules and excessive dry corn starch into a two-dimensional motion mixer to mix again;
500, tabletting the mixed granules and the dried corn starch by a rotary tablet press to obtain tablet cores;
step 600, dissolving polyacrylic resin II with ethanol, adding castor oil, diethyl phthalate, tween-80 and talcum powder to prepare an enteric coating liquid, coating the tablet core with the enteric coating liquid by using high-efficiency sugar coating and film coating equipment, and drying to obtain a finished product.
The sucrose is crushed by a crusher, the corn starch is screened by a 100-mesh screen by a vortex type oscillating screen, and the dextrin does not need to be crushed and screened.
In step 100, the specific steps of granulating the dextrin, the pulverized corn starch and the sucrose to obtain blank granules are as follows:
sequentially mixing dried corn starch, sucrose and dextrin into a barrel according to the formula, and pouring the mixture into a mixing machine for mixing;
adding purified water into the mixed starch, sucrose and dextrin, and mixing for 2-10 minutes to obtain a soft material;
granulating the prepared soft material by using a swing granulator, drying by using a boiling drying box, and granulating the dried material into granules.
Because aspirin is stable in dry air and slowly hydrolyzed into salicylic acid and acetic acid when meeting tide, if aspirin is contacted with water, ethanol or other solvents, and then heated and dried under the condition of damp heat, the decomposition of aspirin raw materials is promoted, and the excessive free salicylic acid is easily caused. In order to solve the problem that aspirin is easy to decompose after encountering a solvent, blank particles and aspirin are mixed and then subjected to primary tabletting through a tablet press to obtain a planar tablet, the planar tablet is put into a swing granulator to be prepared into particles, the particles and weighed dry corn starch are put into a two-dimensional motion mixer to be mixed again, and a tablet core is obtained through tabletting through a rotary tablet press. No solvent is introduced during the mixing and tabletting processes, thus ensuring the aspirin content and reducing the free salicylic acid content.
The aspirin enteric-coated tablet prepared by mixing the blank particles and aspirin together can effectively prevent aspirin from being heated and external moisture from permeating, prevent aspirin from being hydrolyzed and effectively reduce the content of free salicylic acid; meanwhile, aspirin is prevented from disintegrating in gastric juice, but the disintegration and dissolution effects of aspirin in intestinal tracts can be guaranteed.
Based on the method, the invention provides a production device of aspirin enteric-coated tablets corresponding to the method, which generally comprises a sieving device, a crushing device, a mixing device, a drying device, a tabletting device, a granulating device and a packaging device.
Wherein the sieving device is a vortex type oscillating sieve, the crushing device is a 320-IV stainless steel crusher, the drying device is a boiling drying box, the mixing device is a two-dimensional motion mixer, the granulating device is a swing granulator, and the tabletting device is a ZP35D tablet press. In the process of producing the aspirin enteric-coated tablet, the corn starch is weighed, sieved by using a vortex type oscillating screen, and ground by using a 320-IV stainless steel grinder after the sucrose is weighed; mixing the sieved corn starch, the crushed cane sugar and the dextrin according to a prescription; mixing with a two-dimensional motion mixer, adding purified water into the mixed starch, sucrose and dextrin, mixing for 2-10 minutes to prepare a soft material, granulating the prepared soft material with a swing granulator, drying through a boiling drying box, granulating the dried material, and preparing granules to obtain blank granules;
weighing corn starch, drying, and sieving by using a vortex type oscillating screen to obtain dry corn starch with a specified granularity;
respectively weighing aspirin and blank particles, sequentially putting the aspirin and the blank particles into a blending barrel, adding excessive dry corn starch into the blending barrel, and putting the blended aspirin, the blank particles and the dry corn starch into a two-dimensional motion mixer for total mixing;
performing primary tabletting by ZP35D tablet press to obtain planar tablet, granulating in swing granulator, and mixing with excessive dried corn starch in two-dimensional motion mixer;
tabletting the mixed granules and the dried corn starch by a rotary tablet press to obtain tablet cores;
dissolving polyacrylic resin II with ethanol, adding castor oil, diethyl phthalate, tween-80 and talcum powder to obtain enteric coating liquid, coating tablet core with the enteric coating liquid by using high-efficiency sugar coating and film coating equipment, and drying to obtain finished tablet;
and finally, filling the tablets into medicine bottles by using packaging equipment to obtain finished products.
Wherein, most raw materials are powder materials, and the powder material addition is difficult to be accurately controlled, so the invention provides a powder material adding device on the mixing device.
Specifically, as shown in fig. 2, the powder adding device includes a feeding hopper 3, a material collecting barrel 4 and a material receiving box 5, the material collecting barrel 4 is arranged in the material receiving box 5, an output end of the feeding hopper 3 is located right above the material collecting barrel 4, the material collecting barrel 4 includes a base 401, a barrel 402 vertically penetrates through the base 401, a lower end of the barrel 402 is flush with a lower end face of the base 401, a barrel closing plate 403 for closing a lower end outlet of the barrel 402 is arranged on a lower surface of the base 401, a top flat plate 404 is arranged on a top end of the barrel 402, an upper end outlet of the barrel 402 is flush with the top flat plate 404, a horizontal pushing cylinder 405 is arranged in the material receiving box 5, the horizontal pushing cylinder 405 is horizontally fixed on an inner wall of the material receiving box 5, an output end of the horizontal pushing cylinder 405 is connected with a horizontal pushing plate 406, the horizontal pushing plate 406 is opposite to the barrel.
When powder is added, powder enters from the hopper 3 and falls into the collecting cylinder 4, at first, the barrel closing plate 403 closes the lower end outlet of the collecting cylinder 4, so that the powder is accumulated in the collecting cylinder 4, with the continuous addition of the powder, after the collecting cylinder 4 is fully collected with the powder, the surplus powder is accumulated on the top end of the collecting cylinder 4 in a conical shape, more powder falls from the collecting cylinder 4 into the material receiving box 5, at the moment, the output end of the horizontal pushing cylinder 405 extends out to drive the horizontal pushing plate 406 to move laterally, when the horizontal pushing plate 406 grazes the barrel 402, the conical powder accumulated on the top of the barrel 402 is pushed to the material receiving box 5, so that the volume of the powder in the barrel 402 is the standard capacity of the barrel 402, then, the barrel closing plate 403 is moved away to expose the lower end outlet of the barrel 402, the bottom of the material receiving box 5 is provided with a notch for the downward extension of the barrel 402, and the lower end of the barrel 402 is timely connected with the inlet of the, the powder enters the mixing device from the barrel 402.
Through the setting, the volume when the powder adds can be controlled, the standard volume of barrel 402 is made, and the input volume through controlling the powder, the weight of control powder input can be reached to realize the accurate input of powder, material ratio is chaotic when avoiding mixing, thereby reaches better mixed effect.
Specifically, as shown in fig. 4, two clamping plates 407 are arranged in parallel on the lower end surface of the base 401, the clamping plates 407 are L-shaped, a sliding groove 408 is formed between the two clamping plates 407, two ends of the sliding groove 408 are provided with limiting seats 412, the cylinder closing plate 403 is slidably disposed in the sliding groove 408, the upper end surface of the cylinder closing plate 403 is closely attached to the base 401, the lower surface of the cylinder closing plate 403 is provided with a closing rack 409, the lower end surface of the base 401 is provided with a closing motor 410, an output shaft of the closing motor 410 is provided with a closing gear 411, the closing gear 411 is engaged with the closing rack 409, and the closing motor 410 drives the closing gear 411 to rotate, so that the cylinder closing plate 403 slides in the sliding groove 408, thereby closing the lower end outlet of the.
Furthermore, in order to avoid the empty bag of the powder in the cylinder 402, the powder is more compact, so that the powder amount reaches the standard volume of the cylinder 402, a vertical vibration component 1 for driving the cylinder 402 to vibrate vertically is arranged in the material receiving box 5, as shown in fig. 1 and 2, the vertical vibration component 1 includes a mounting seat 101 disposed in the material receiving box 5, a through hole 102 is disposed at the center of the mounting seat 101, a cylinder 402 penetrates through the through hole 102, a top plate 404 and a base 401 are respectively disposed at the upper end and the lower end of the mounting seat 101, no contact is made between the cylinder 402 and the through hole 102, a stretching cylinder 103 is disposed on the lower end face of the top plate 404, an output end of the stretching cylinder 103 is vertically downward and is provided with a permanent magnet 104, an electromagnetic block 105 is disposed on the upper end face of the mounting seat 101, the permanent magnet 104 is disposed right above the electromagnetic block 105, a vibration spring 106 is disposed between the top plate 404 and the mounting seat 101, and the vibration spring 106 is disposed outside the.
In the vertical vibration module 1 described above, the output end of the stretching cylinder 103 is in a contracted state at the beginning, the permanent magnet 104 is not in contact with the electromagnet block 105, and the electromagnet block 105 is in a non-energized state, when the vertical vibration component 1 works, the output end of the stretching cylinder 103 extends out until the electromagnetic block 105 is contacted with the permanent magnet 104, at the moment, the electromagnetic block 105 is electrified to have magnetism and attract the permanent magnet 104, then the output end of the tension cylinder 103 is retracted, so that the cylinder 402 moves down, and the vibration spring 106 is compressed, after the stretching cylinder 103 retracts to the limit, the electromagnetic block 105 is powered off, the permanent magnet 104 is not adsorbed any more, the cylinder 402 rebounds upwards under the action of the vibrating spring 106 and continuously vibrates after returning to the original position, thereby the powder in the cylinder 402 is continuously shaken to eliminate empty bags, and the powder is accumulated in a more dense chamber, so that the powder amount reaches the standard volume of the cylinder 402.
Specifically, as shown in fig. 2, the output end of the stretching cylinder 103 in the vertical vibration component 1 is connected with the vertical guide rod 107, the lower end of the guide rod 107 passes through the mounting seat 101, the permanent magnet 105 is annular and is arranged at the top periphery of the guide rod 107, the electromagnetic block 104 is annular and is sleeved outside the guide rod 107, the lower end of the mounting seat 101 is connected with the mounting cylinder 108, the lower end of the mounting cylinder 108 passes through the material receiving box 5, the lower end edge of the top flat plate 404 is connected with the side sliding plate 109, the side sliding plate 109 inclines outwards from top to bottom, and the bottom end of the side sliding plate 109 is located outside the mounting seat 101.
Further, in order to further eliminate the empty package and make the powder material more dense, a vibration knocking component 2 capable of making the cylinder 402 vibrate laterally is further arranged in the material receiving box 5, as shown in fig. 5 and 6, the vibration knocking component 2 comprises a vibration knocking base 201 fixed on the inner wall of the material receiving box 5, a vibration knocking lead screw 202 and a vibration knocking lever 203 are arranged on the vibration knocking base 201 through a support, the vibration knocking lead screw 202 is a reciprocating lead screw and is provided with a lead screw nut seat 204, the lead screw nut seat 204 is connected with one end of the vibration knocking lever 203, the other end of the vibration knocking lever 203 is connected with a vibration knocking block 205, and one end of the vibration knocking lead screw 202 is connected with a lead screw motor 206.
In the above-mentioned vibration component 2, the screw motor 206 drives the vibration screw 202 to rotate, so that the screw nut seat 204 moves on the vibration screw 202, and drives the vibration lever 203 to rotate, so that the vibration block 205 is knocked on the cylinder 402, thereby realizing the lateral vibration of the cylinder 402, further eliminating the empty package, and making the powder material more dense.
Meanwhile, the vibration component 2 can be used not only in the process of adding powder to the cylinder 402, but also in the process of adding powder to the mixing equipment from the cylinder 402, at the moment, the powder can fall out more quickly and smoothly when the vibration component 2 is used, and the powder attached to the inner wall of the cylinder 402 can fall down through vibration, so that the powder is prevented from remaining in the cylinder 402, the accurate addition of the powder is realized, and the inconvenience in the subsequent powder removing process on the inner wall of the cylinder 402 is avoided.
According to the powder adding device provided by the invention, the powder falls into the material collecting barrel 4 firstly, then falls into the mixing equipment through the material collecting barrel 4, the accurate control of the volume can be realized after the powder falls into the material collecting barrel 4, and then the accurate control of the powder adding weight can be realized by utilizing the conversion relation between the volume and the mass of the powder, so that the accurate proportioning of the enteric-coated tablets is facilitated.
Although the invention has been described in detail above with reference to a general description and specific examples, it will be apparent to one skilled in the art that modifications or improvements may be made thereto based on the invention. Accordingly, such modifications and improvements are intended to be within the scope of the invention as claimed.
Claims (10)
1. A production method of aspirin enteric-coated tablets is characterized by comprising the following steps:
step 100, weighing corn starch, sieving, weighing cane sugar and crushing; mixing the sieved corn starch, the crushed cane sugar and the dextrin according to a prescription; mixing the materials by a mixer and granulating to obtain blank particles;
step 200, weighing corn starch, drying and sieving to obtain dried corn starch with specified granularity;
step 300, respectively weighing aspirin and blank particles, sequentially putting the aspirin and the blank particles into a blending barrel, adding excessive dry corn starch into the blending barrel, and putting the blended aspirin, the blank particles and the dry corn starch into a two-dimensional motion mixer for total mixing;
step 400, after the total mixing, performing primary tabletting through a tabletting machine to obtain a planar tablet, putting the planar tablet into a swing granulator to prepare granules, and putting the granules and excessive dry corn starch into a two-dimensional motion mixer to mix again;
500, tabletting the mixed granules and the dried corn starch by a rotary tablet press to obtain tablet cores;
step 600, dissolving polyacrylic resin II with ethanol, adding castor oil, diethyl phthalate, tween-80 and talcum powder to prepare an enteric coating liquid, coating the tablet core with the enteric coating liquid by using high-efficiency sugar coating and film coating equipment, and drying to obtain a finished product.
2. The method for producing aspirin enteric-coated tablets according to claim 1, wherein sucrose is pulverized by a pulverizer, corn starch is sieved by a 100-mesh sieve by vortex type oscillation, and dextrin is not pulverized and sieved.
3. The method for producing aspirin enteric-coated tablets according to claim 1, characterized in that in step 100, the specific steps of granulating dextrin, pulverized corn starch and sucrose to obtain blank granules are as follows:
sequentially mixing dried corn starch, sucrose and dextrin into a barrel according to the formula, and pouring the mixture into a mixing machine for mixing;
adding purified water into the mixed starch, sucrose and dextrin, and mixing for 2-10 minutes to obtain a soft material;
granulating the prepared soft material by using a swing granulator, drying by using a boiling drying box, and granulating the dried material into granules.
4. A powder adding device for the method of any one of claims 1 to 3, comprising a feeding hopper (3), a material collecting barrel (4) and a material receiving box (5), wherein the material collecting barrel (4) is arranged in the material receiving box (5), the output end of the feeding hopper (3) is positioned right above the material collecting barrel (4), the material collecting barrel (4) comprises a base (401), a barrel (402) is vertically penetrated on the base (401), the lower end of the barrel (402) is flush with the lower end surface of the base (401), the lower surface of the base (401) is provided with a barrel closing plate (403) for closing the lower end outlet of the barrel (402), the top end of the barrel (402) is provided with a top flat plate (404), the upper end outlet of the barrel (402) is flush with the top flat plate (404), and a horizontal pushing cylinder (405) is arranged in the material receiving box (5), the horizontal pushing cylinder (405) is horizontally fixed on the inner wall of the material receiving box (5), the output end of the horizontal pushing cylinder (405) is connected with a horizontal pushing plate (406), the horizontal pushing plate (406) is right opposite to the cylinder body (402), and the lower end surface of the horizontal pushing plate (406) is flush with the upper surface of the top flat plate (404).
5. The powder adding device according to claim 4, wherein two clamping plates (407) are arranged in parallel on the lower end surface of the base (401), the clamping plates (407) are L-shaped, a sliding groove (408) is formed between the two clamping plates (407), the barrel closing plate (403) is arranged in the sliding groove (408) in a sliding manner, the upper end surface of the barrel closing plate (403) is closely attached to the base (401), a closing rack (409) is arranged on the lower surface of the barrel closing plate (403), a closing motor (410) is arranged on the lower end surface of the base (401), a closing gear (411) is arranged on an output shaft of the closing motor (410), the closing gear (411) is engaged with the closing rack (409), and the closing motor (410) drives the closing gear (411) to rotate so that the barrel closing plate (403) slides in the sliding groove (408), thereby closing the lower outlet of the cylinder (402).
6. A powder adding device as claimed in claim 5, wherein both ends of said sliding groove (408) are provided with a limiting seat (412).
7. The powder adding device according to claim 4, wherein a vertical vibration component (1) is arranged in the material receiving box (5), the vertical vibration component (1) comprises a mounting seat (101) arranged in the material receiving box (5), a through hole (102) is arranged at the center of the mounting seat (101), the cylinder (402) penetrates through the through hole (102), the top plate (404) and the base (401) are respectively arranged at the upper end and the lower end of the mounting seat (101), no contact is formed between the cylinder (402) and the through hole (102), the lower end face of the top plate (404) is provided with a stretching cylinder (103), the output end of the stretching cylinder (103) is vertically downward and provided with a permanent magnet (104), the upper end face of the mounting seat (101) is provided with an electromagnetic block (105), and the permanent magnet (104) is arranged right above the electromagnetic block (105), a vibration spring (106) is arranged between the top flat plate (404) and the mounting seat (101), and the vibration spring (106) is located outside the stretching cylinder (103).
8. The powder adding device according to claim 7, wherein the output end of the stretching cylinder (103) is connected with a vertical guide rod (107), the lower end of the guide rod (107) passes through the mounting seat (101), the permanent magnet (105) is annular and is arranged on the periphery of the top of the guide rod (107), and the electromagnetic block (104) is annular and is sleeved outside the guide rod (107).
9. The powder adding production device of claim 8, wherein the lower end of the mounting seat (101) is connected with a mounting cylinder (108), the lower end of the mounting cylinder (108) passes through the material receiving box (5), the lower end edge of the top plate (404) is connected with a side sliding plate (109), the side sliding plate (109) is inclined outwards from top to bottom, and the bottom end of the side sliding plate (109) is located outside the mounting seat (101).
10. The powder adding device according to claim 4, wherein a vibration knocking component (2) is further arranged in the material receiving box (5), the vibration knocking component (2) comprises a vibration knocking base (201) fixed on the inner wall of the material receiving box (5), a vibration knocking lead screw (202) and a vibration knocking lever (203) are arranged on the vibration knocking base (201) through a support, the vibration knocking lead screw (202) is a reciprocating lead screw and is provided with a lead screw nut seat (204), the lead screw nut seat (204) is connected with one end of the vibration knocking lever (203), the other end of the vibration knocking lever (203) is connected with a vibration knocking block (205), one end of the vibration knocking lead screw (202) is connected with a lead screw motor (206), and the lead screw motor (206) drives the vibration knocking lead screw (202) to rotate, so that the lead screw nut seat (204) moves on the vibration knocking lead screw (202), the vibration lever (203) is driven to rotate, so that the vibration block (205) is vibrated on the cylinder (402).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202010677585.6A CN111821273A (en) | 2020-07-13 | 2020-07-13 | Production method of aspirin enteric-coated tablets and powder adding device |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202010677585.6A CN111821273A (en) | 2020-07-13 | 2020-07-13 | Production method of aspirin enteric-coated tablets and powder adding device |
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| CN111821273A true CN111821273A (en) | 2020-10-27 |
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| CN202010677585.6A Pending CN111821273A (en) | 2020-07-13 | 2020-07-13 | Production method of aspirin enteric-coated tablets and powder adding device |
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Application publication date: 20201027 |