CN111632034A - Preparation process and equipment of carbocisteine tablets - Google Patents
Preparation process and equipment of carbocisteine tablets Download PDFInfo
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- CN111632034A CN111632034A CN202010346870.XA CN202010346870A CN111632034A CN 111632034 A CN111632034 A CN 111632034A CN 202010346870 A CN202010346870 A CN 202010346870A CN 111632034 A CN111632034 A CN 111632034A
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- carbocisteine
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- GBFLZEXEOZUWRN-VKHMYHEASA-N S-carboxymethyl-L-cysteine Chemical compound OC(=O)[C@@H](N)CSCC(O)=O GBFLZEXEOZUWRN-VKHMYHEASA-N 0.000 title claims abstract description 47
- 229960004399 carbocisteine Drugs 0.000 title claims abstract description 47
- 238000002360 preparation method Methods 0.000 title claims abstract description 21
- 238000002156 mixing Methods 0.000 claims abstract description 79
- 230000007246 mechanism Effects 0.000 claims abstract description 33
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 14
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 claims abstract description 14
- 235000007119 Ananas comosus Nutrition 0.000 claims abstract description 10
- 229920000881 Modified starch Polymers 0.000 claims abstract description 10
- 229920002261 Corn starch Polymers 0.000 claims abstract description 7
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims abstract description 7
- 229920000168 Microcrystalline cellulose Polymers 0.000 claims abstract description 7
- UEDUENGHJMELGK-HYDKPPNVSA-N Stevioside Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1O[C@]12C(=C)C[C@@]3(C1)CC[C@@H]1[C@@](C)(CCC[C@]1([C@@H]3CC2)C)C(=O)O[C@H]1[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O1)O)[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O UEDUENGHJMELGK-HYDKPPNVSA-N 0.000 claims abstract description 7
- 239000008120 corn starch Substances 0.000 claims abstract description 7
- 229940031703 low substituted hydroxypropyl cellulose Drugs 0.000 claims abstract description 7
- 235000019359 magnesium stearate Nutrition 0.000 claims abstract description 7
- 235000019813 microcrystalline cellulose Nutrition 0.000 claims abstract description 7
- 239000008108 microcrystalline cellulose Substances 0.000 claims abstract description 7
- 229940016286 microcrystalline cellulose Drugs 0.000 claims abstract description 7
- 239000011734 sodium Substances 0.000 claims abstract description 7
- 229910052708 sodium Inorganic materials 0.000 claims abstract description 7
- 235000000346 sugar Nutrition 0.000 claims abstract description 7
- 238000003756 stirring Methods 0.000 claims description 37
- 239000000463 material Substances 0.000 claims description 21
- 238000007580 dry-mixing Methods 0.000 claims description 12
- 241000234671 Ananas Species 0.000 claims description 9
- 238000007599 discharging Methods 0.000 claims description 7
- 238000009835 boiling Methods 0.000 claims description 6
- 238000013329 compounding Methods 0.000 claims description 6
- 238000001035 drying Methods 0.000 claims description 6
- 230000001681 protective effect Effects 0.000 claims description 6
- 239000002994 raw material Substances 0.000 claims description 6
- 238000005303 weighing Methods 0.000 claims description 6
- 239000008187 granular material Substances 0.000 claims description 5
- 238000005469 granulation Methods 0.000 claims description 4
- 230000003179 granulation Effects 0.000 claims description 4
- 239000002245 particle Substances 0.000 claims description 4
- 229920002472 Starch Polymers 0.000 claims description 3
- 125000002057 carboxymethyl group Chemical group [H]OC(=O)C([H])([H])[*] 0.000 claims description 3
- 235000013339 cereals Nutrition 0.000 claims description 3
- 239000000428 dust Substances 0.000 claims description 3
- 239000011521 glass Substances 0.000 claims description 3
- 235000021552 granulated sugar Nutrition 0.000 claims description 3
- 238000004806 packaging method and process Methods 0.000 claims description 3
- 239000000843 powder Substances 0.000 claims description 3
- 238000007789 sealing Methods 0.000 claims description 3
- 239000007779 soft material Substances 0.000 claims description 3
- 238000005507 spraying Methods 0.000 claims description 3
- 235000019698 starch Nutrition 0.000 claims description 3
- 239000008107 starch Substances 0.000 claims description 3
- 229940032147 starch Drugs 0.000 claims description 3
- 229940013618 stevioside Drugs 0.000 claims description 3
- OHHNJQXIOPOJSC-UHFFFAOYSA-N stevioside Natural products CC1(CCCC2(C)C3(C)CCC4(CC3(CCC12C)CC4=C)OC5OC(CO)C(O)C(O)C5OC6OC(CO)C(O)C(O)C6O)C(=O)OC7OC(CO)C(O)C(O)C7O OHHNJQXIOPOJSC-UHFFFAOYSA-N 0.000 claims description 3
- 235000019202 steviosides Nutrition 0.000 claims description 3
- 238000009423 ventilation Methods 0.000 claims description 3
- 238000005550 wet granulation Methods 0.000 claims description 3
- 235000020985 whole grains Nutrition 0.000 claims description 3
- 230000008878 coupling Effects 0.000 claims description 2
- 238000010168 coupling process Methods 0.000 claims description 2
- 238000005859 coupling reaction Methods 0.000 claims description 2
- 230000000694 effects Effects 0.000 abstract description 6
- 238000004519 manufacturing process Methods 0.000 abstract description 4
- 244000099147 Ananas comosus Species 0.000 abstract 1
- 238000010521 absorption reaction Methods 0.000 description 3
- 238000010586 diagram Methods 0.000 description 3
- 230000035939 shock Effects 0.000 description 3
- 230000001360 synchronised effect Effects 0.000 description 3
- 206010036790 Productive cough Diseases 0.000 description 2
- 230000000857 drug effect Effects 0.000 description 2
- 230000028327 secretion Effects 0.000 description 2
- 206010006458 Bronchitis chronic Diseases 0.000 description 1
- 208000006673 asthma Diseases 0.000 description 1
- 206010006451 bronchitis Diseases 0.000 description 1
- 230000003139 buffering effect Effects 0.000 description 1
- 208000007451 chronic bronchitis Diseases 0.000 description 1
- 230000008602 contraction Effects 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 210000004907 gland Anatomy 0.000 description 1
- 208000030603 inherited susceptibility to asthma Diseases 0.000 description 1
- 238000000034 method Methods 0.000 description 1
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- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 208000024794 sputum Diseases 0.000 description 1
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Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
- A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2095—Tabletting processes; Dosage units made by direct compression of powders or specially processed granules, by eliminating solvents, by melt-extrusion, by injection molding, by 3D printing
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/10—Expectorants
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F31/00—Mixers with shaking, oscillating, or vibrating mechanisms
- B01F31/40—Mixers with shaking, oscillating, or vibrating mechanisms with an axially oscillating rotary stirrer
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F31/00—Mixers with shaking, oscillating, or vibrating mechanisms
- B01F31/44—Mixers with shaking, oscillating, or vibrating mechanisms with stirrers performing an oscillatory, vibratory or shaking movement
- B01F31/441—Mixers with shaking, oscillating, or vibrating mechanisms with stirrers performing an oscillatory, vibratory or shaking movement performing a rectilinear reciprocating movement
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
- B01F35/40—Mounting or supporting mixing devices or receptacles; Clamping or holding arrangements therefor
- B01F35/43—Supporting receptacles on frames or stands
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F2101/00—Mixing characterised by the nature of the mixed materials or by the application field
- B01F2101/22—Mixing of ingredients for pharmaceutical or medical compositions
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Pulmonology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Medicinal Preparation (AREA)
Abstract
The invention discloses a carbocisteine tablet, which comprises the following components in parts by weight: 1000 parts of carbocisteine, 120 parts of corn starch, 200 parts of pregelatinized starch, 2800 parts of powdered sugar, 200 parts of low-substituted hydroxypropyl cellulose, 500 parts of 30% ethanol, 16.5 parts of magnesium stearate, 120 parts of sodium carbocisteine, 120 parts of microcrystalline cellulose, 15 parts of steviosin and 3 parts of pineapple essence; the preparation equipment comprises a mixing tank, reciprocating mechanisms are installed on two sides of the mixing tank, a protection box is installed on each reciprocating mechanism, a cavity is arranged in each protection box, an automatic lifting mechanism is arranged in each cavity, a support column is installed on each automatic lifting mechanism, and a transverse plate is fixed to the upper end of each support column. The invention not only can enlarge the processing capacity of the total mixing of the carbocisteine tablets, but also can ensure the mixing effect of the total mixing, greatly shortens the processing time, enhances the processing efficiency and reduces the production cost.
Description
Technical Field
The invention relates to the technical field of carbocisteine tablet processing, in particular to a carbocisteine tablet preparation process and device.
Background
The carbocisteine tablet mainly acts on the secretion of bronchial glands, increases the secretion of low-viscosity salivary mucin, reduces the generation of high-viscosity fucomucin, reduces the viscosity of sputum to facilitate expectoration, and has quick oral effect, because the carbocisteine tablet is applied on a large scale in treating diseases such as chronic bronchitis, bronchial asthma and the like.
The existing carbocisteine production process has the problems of low product yield (80.0%), low product content (98.5%) and the like, reduces the drug effect and quality of carbocisteine to a certain extent, and influences the treatment effect of the drug; in the production process of the carbocisteine tablet, after different raw materials are processed, the different raw materials need to be subjected to total mixing operation, however, the existing carbocisteine tablet total mixing mode adopts a simple mixing stirrer to stir and mix, the mode is low in efficiency and long in mixing time, in addition, the single mixing amount is small, the processing efficiency of the carbocisteine tablet is seriously reduced, and therefore, a carbocisteine tablet preparation process and equipment are provided to solve the problems.
Disclosure of Invention
The invention aims to solve the defects in the prior art and provides a preparation process and equipment of carbocisteine tablets.
In order to achieve the purpose, the invention adopts the following technical scheme:
the carbocisteine tablet comprises the following components in parts by weight: 1000 parts of carbocisteine, 120 parts of corn starch, 200 parts of pregelatinized starch, 2800 parts of powdered sugar, 200 parts of low-substituted hydroxypropyl cellulose, 500 parts of 30% ethanol, 16.5 parts of magnesium stearate, 120 parts of sodium carbocisteine, 120 parts of microcrystalline cellulose, 15 parts of steviosin and 3 parts of pineapple essence;
a preparation process of carbocisteine tablets comprises the following steps:
s1, weighing: weighing the raw materials according to the weight ratio; wherein the white granulated sugar is crushed and sieved by a sieve of 80 meshes for standby; adding pineapple essence into a sprinkling can for later use;
s2, granulating: adding corn starch, pregelatinized starch, sugar powder, low-substituted hydroxypropyl cellulose and carbocisteine into a material barrel of a wet mixing granulator for dry mixing, wherein the dry mixing time is 5min, the dry mixing stirring speed is 100rpm, and the dry mixing flying knife speed is 1000 rpm; then adding 30% ethanol into a material barrel of the granulator, and carrying out wet granulation, wherein the wet mixing time is 3min, the wet mixing stirring speed is 120rpm, and the wet mixing flying cutter speed is 500 rpm; the time delay of guniting is 0s, the total time of guniting is 120s, the interval time of guniting is 0s, and the guniting time is 120 s; then starting automatic granulation to prepare a soft material, starting a discharge door, starting intermittent stirring, granulating by using a 18-mesh screen, and sucking the granules into a fluidized bed dryer through a closed pipeline;
s3, drying: starting a boiling dryer, opening an air inlet valve, an air exhaust valve and an air exhaust fan in sequence, and carrying out ventilation drying for 2 minutes at the temperature of 55-75 ℃; adjusting the air exhaust frequency to enable the material to be in a slight boiling state, manually removing dust, starting a material container discharge valve, starting a vacuum feeder, sucking dried particles into a finishing platform, closing an air exhaust fan, opening a sight glass window, and sucking residual materials in the material container into a finishing platform;
s4, finishing the grains: installing a screen with the aperture of 3mm on the granulating platform, connecting a discharge port of the granulating platform with a feed inlet of a mixing barrel filled with magnesium stearate, carboxymethyl starch sodium, pregelatinized starch, microcrystalline cellulose and stevioside, sucking dried granules into a buffer tank of the granulating platform through a vacuum feeding machine, starting a granulator, adjusting the granulating rotation speed to 80rpm, and starting granulating;
s5, total mixing: disconnecting the discharge port of the whole grain platform and the feed inlet of the mixing barrel, spraying the standby pineapple essence, sealing the feed inlet of the mixing barrel, fixing the total mixing barrel, and mixing for 25 minutes at 12 r/min. Mixing is completed;
and S6, tabletting and packaging.
The utility model provides a carbocisteine piece preparation equipment, includes the compounding jar, reciprocating motion mechanism is all installed to the both sides of compounding jar, the last protection box of installing of reciprocating motion mechanism, be equipped with the cavity in the protection box, be equipped with automatic lifting mechanism in the cavity, the last support column of installing of automatic lifting mechanism, the upper end of support column is fixed with the diaphragm, is fixed with the guard box between two diaphragms jointly, the upper end both sides of compounding jar all are equipped with the recess, it is provided with the gyro wheel to remove in the recess, the upper end of gyro wheel is connected with buffer gear, and buffer gear's upper end is connected on the diaphragm, be equipped with two agitating unit in the guard box, the upper end of guard box is equipped with two openings, and two agitating unit's lower extreme runs through two openings and extends to in the compounding jar, the lower extreme of.
Preferably, the automatic lifting mechanism is including rotating the screw rod of connecting the bottom in the cavity, the upper end screw thread of screw rod cup joints the lower extreme at the support column, and the upper end of support column runs through the lateral wall of protection box, the both sides of support column all are fixed with the slider, all be equipped with the spout that corresponds with the slider on the relative lateral wall in the cavity, and the slider is located the spout, fixed cover is equipped with first conical gear on the screw rod, servo motor is installed to one side of protection box, servo motor's output shaft end runs through the lateral wall of protection box and extends to in the cavity, servo motor's output shaft end is fixed with second conical gear, and second conical gear and first conical gear intermeshing.
Preferably, agitating unit is including fixing the driving motor in the guard box, driving motor's output shaft is terminal to be connected with the puddler through the shaft joint, the puddler runs through the opening that corresponds and extends to in the compounding jar, the equidistant a plurality of stirring leaves that are equipped with on a week lateral wall of puddler.
Preferably, the reciprocating mechanism comprises fixed plates fixed on two sides of the mixing tank, a moving groove is formed in each fixed plate, a hydraulic cylinder is installed on one side of each fixed plate, a moving block is installed in each moving groove, the lower end of each protection box is fixed to the upper end of each moving block, and a piston rod of each hydraulic cylinder penetrates through the side wall of each fixed plate and is fixed to one side of each moving block.
Preferably, buffer gear is including fixing the connecting plate in the gyro wheel upper end, the upper end of connecting plate is fixed with the guide bar, the upper end of guide bar runs through the lateral wall of diaphragm and extends to the upper end of diaphragm, the cover is equipped with the spring on the guide bar, the upper end of spring is contradicted at the lower extreme of diaphragm, the lower extreme of spring is contradicted in the upper end of connecting plate.
Preferably, the discharging mechanism comprises a discharging pipe connected to the middle part of the lower end of the mixing tank, and a valve is mounted on the discharging pipe.
Preferably, four corners of the lower end of the mixing tank are respectively fixed with a support leg, and the lower ends of the support legs are fixed with a base plate; the length of the opening is consistent with that of the moving groove.
Preferably, the stirring blades are provided with a plurality of bumps at equal intervals.
The carbocisteine tablet prepared by the process has good product quality, high yield and guaranteed drug effect. The equipment provided by the invention not only can expand the processing capacity of the carbocisteine tablets during total mixing, but also can ensure the mixing effect of the carbocisteine tablets during total mixing, greatly shortens the processing time, enhances the processing efficiency, reduces the production cost and improves the practicability of the total mixing.
Drawings
FIG. 1 is a schematic diagram of the internal structure of a carbocisteine tablet preparation device provided by the invention;
FIG. 2 is a schematic diagram of the external structure of a carbocisteine tablet preparation device provided by the invention;
FIG. 3 is a schematic structural diagram of a reciprocating mechanism according to the present invention;
FIG. 4 is a flow chart of the preparation process of carbocisteine tablets provided by the invention;
FIG. 5 is an enlarged view of the structure at position A according to the present invention;
fig. 6 is an enlarged view of the structure at B according to the present invention.
In the figure: the device comprises a guide rod 1, a transverse plate 2, a mixing tank 3, a support column 4, a mixing blade 5, a mixing rod 6, a servo motor 7, a protection box 8, a moving block 9, a support leg 10, a discharge pipe 11, a valve 12, a driving motor 13, a protection box 14, a hydraulic cylinder 15, a fixed plate 16, a sliding groove 17, a sliding block 18, a screw rod 19, a first conical gear 20, a second conical gear 21, a spring 22, a connecting plate 23, a roller 24 and a moving groove 25.
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments.
In the invention, the carbocisteine tablet comprises the following components in parts by weight: 1000 parts of carbocisteine, 120 parts of corn starch, 200 parts of pregelatinized starch, 2800 parts of powdered sugar, 200 parts of low-substituted hydroxypropyl cellulose, 500 parts of 30% ethanol, 16.5 parts of magnesium stearate, 120 parts of sodium carbocisteine, 120 parts of microcrystalline cellulose, 15 parts of steviosin and 3 parts of pineapple essence.
In the invention, the preparation process of the carbocisteine tablet comprises the following steps:
s1, weighing: weighing the raw materials according to the weight ratio; wherein the white granulated sugar is crushed and sieved by a sieve of 80 meshes for standby; adding pineapple essence into a sprinkling can for later use;
s2, granulating: adding 100 parts of corn starch, 100 parts of pregelatinized starch, sugar powder, low-substituted hydroxypropyl cellulose and carbocisteine into a material barrel of a wet mixing granulator for dry mixing, wherein the dry mixing time is 5min, the dry mixing stirring speed is 100rpm, and the dry mixing flying knife speed is 1000 rpm; then adding 30% ethanol into a material barrel of the granulator, and carrying out wet granulation, wherein the wet mixing time is 3min, the wet mixing stirring speed is 120rpm, and the wet mixing flying cutter speed is 500 rpm; the time delay of guniting is 0s, the total time of guniting is 120s, the interval time of guniting is 0s, and the guniting time is 120 s; then starting automatic granulation to prepare a soft material, starting a discharge door, starting intermittent stirring, granulating by using a 18-mesh screen, and sucking the granules into a fluidized bed dryer through a closed pipeline;
s3, drying: starting a boiling dryer, opening an air inlet valve, an air exhaust valve and an air exhaust fan in sequence, and carrying out ventilation drying for 2 minutes at the temperature of 55-75 ℃; adjusting the air exhaust frequency to enable the material to be in a slight boiling state, manually removing dust, starting a material container discharge valve, starting a vacuum feeder, sucking dried particles into a finishing platform, closing an air exhaust fan, opening a sight glass window, and sucking residual materials in the material container into a finishing platform;
s4, finishing the grains: installing a sieve with the aperture of 3mm on the granulating platform, connecting a discharge port of the granulating platform with a feed inlet of a mixing barrel filled with magnesium stearate, carboxymethyl starch sodium, 100 parts of pregelatinized starch, microcrystalline cellulose and stevioside, sucking dried particles into a buffer tank of the finishing platform through a vacuum feeding machine, starting a granulation machine, adjusting the granulating rotation speed to 80rpm, and starting granulating;
s5, total mixing: disconnecting the discharge port of the whole grain platform and the feed inlet of the mixing barrel, spraying the standby pineapple essence, sealing the feed inlet of the mixing barrel, fixing the total mixing barrel, and mixing for 25 minutes at 12 r/min. Mixing is completed;
and S6, tabletting and packaging.
Referring to fig. 2-6, comprising a mixing tank 3, wherein both sides of the mixing tank 3 are provided with reciprocating mechanisms, the reciprocating mechanisms are provided with protective boxes 8, cavities are arranged in the protective boxes 8, automatic lifting mechanisms are arranged in the cavities, supporting columns 4 are arranged on the automatic lifting mechanisms, transverse plates 2 are fixed at the upper ends of the supporting columns 4, a protective box 14 is jointly fixed between the two transverse plates 2, both sides of the upper end of the mixing tank 3 are provided with grooves, rollers 24 are arranged in the grooves, the upper ends of the rollers 24 are connected with a buffer mechanism, the upper ends of the buffer mechanism are connected to the transverse plates 2, two stirring devices are arranged in the protective box 14, the upper ends of the protective box 14 are provided with two openings, the lower ends of the two stirring devices penetrate through the two openings and extend into the mixing tank 3, the lower end of the mixing tank 3 is connected with a, realize its diversified multi-position intensive mixing, guarantee the effect and the quality of always mixing.
In the invention, the automatic lifting mechanism comprises a screw rod 19 which is rotationally connected with the bottom in the cavity, the upper end of the screw rod 19 is sheathed at the lower end of the supporting column 4 in a threaded manner, the upper end of the supporting column 4 penetrates through the side wall of the protection box 8, sliding blocks 18 are fixed on both sides of the supporting column 4, sliding grooves 17 corresponding to the sliding blocks 18 are arranged on the opposite side walls in the cavity, the slide block 18 is positioned in the slide groove 17, the screw rod 19 is fixedly sleeved with a first conical gear 20, one side of the protection box 8 is provided with the servo motor 7, the tail end of an output shaft of the servo motor 7 penetrates through the side wall of the protection box 8 and extends into the cavity, the tail end of the output shaft of the servo motor 7 is fixed with a second conical gear 21, the second conical gear 21 is meshed with the first conical gear 20, two servo motors 7 controlled by the synchronous control system can synchronously rotate forwards or reversely, so that accurate lifting adjustment is realized.
In the invention, the stirring device comprises a driving motor 13 fixed in a protection box 14, the tail end of an output shaft of the driving motor 13 is connected with a stirring rod 6 through a coupling, the stirring rod 6 penetrates through a corresponding opening and extends into a material mixing tank 3, a plurality of stirring blades 5 are arranged on the side wall of one circle of the stirring rod 6 at equal intervals, the driving motor 13 drives the stirring rod 6 to rotate through the rotation of the output shaft, and then the mixing and stirring of materials by the stirring blades 5 are realized.
In the invention, the reciprocating mechanism comprises a fixed plate 16 fixed on two sides of the mixing tank 3, a moving groove 25 is arranged on the fixed plate 16, a hydraulic cylinder 15 is arranged on one side of the fixed plate 16, a moving block 9 is arranged in the moving groove 25, the lower end of the protection box 8 is fixed on the upper end of the moving block 9, a piston rod of the hydraulic cylinder 15 penetrates through the side wall of the fixed plate 16 and is fixedly fixed on one side of the moving block 9, the hydraulic cylinder 15 drives the moving block 9 to reciprocate through the expansion and contraction of the piston rod, and then the stirring device is driven to move back and forth in the mixing tank.
In the invention, the buffer mechanism comprises a connecting plate 23 fixed at the upper end of a roller 24, a guide rod 1 is fixed at the upper end of the connecting plate 23, the upper end of the guide rod 1 penetrates through the side wall of the transverse plate 2 and extends to the upper end of the transverse plate 2, a spring 22 is sleeved on the guide rod 1, the upper end of the spring 22 abuts against the lower end of the transverse plate 2, the lower end of the spring 22 abuts against the upper end of the connecting plate 23, the discharge mechanism comprises a discharge pipe 11 connected to the middle of the lower end of the mixing tank 3, the spring 22 performs buffer and shock absorption when the stirring device stirs, the roller 24 also performs shock absorption when moving, and a valve 12.
In the invention, the four corners of the lower end of the mixing tank 3 are all fixed with the supporting legs 10, the lower ends of the supporting legs 10 are fixed with the backing plate, the whole mixing tank 3 is stably supported, the length of the opening is consistent with that of the moving groove 25, and the stirring blades 5 are provided with a plurality of convex blocks at equal intervals, so that the stirring efficiency is improved.
In the invention, after each raw material is processed and put into the mixing tank 3, the synchronous control system is used for starting the two servo motors 7, the two servo motors drive the screw rods 19 to rotate under the operation of the two conical gears, so that the downward movement of the support column 4 and the stirring device in the mixing tank 3 is realized, meanwhile, the synchronous control system is used for starting the two hydraulic cylinders 15, the reciprocating movement of the two moving blocks 9 in the moving grooves 25 is realized, the stirring device is driven to move back and forth in the mixing tank 3, the stirring area and the stirring effect are enlarged, the rollers 24 at the upper end move in the grooves during the movement, the springs 22 perform stable shock absorption and buffering during the stirring of the stirring device, the stability is ensured, the valves 12 are opened after the stirring, and the materials are discharged from the discharge pipes 11.
The above description is only for the preferred embodiment of the present invention, but the scope of the present invention is not limited thereto, and any person skilled in the art should be able to cover the technical scope of the present invention and the equivalent alternatives or modifications according to the technical solution and the inventive concept of the present invention within the technical scope of the present invention.
Claims (10)
1. The carbocisteine tablet is characterized by comprising the following components in parts by weight: 1000 parts of carbocisteine, 120 parts of corn starch, 200 parts of pregelatinized starch, 2800 parts of powdered sugar, 200 parts of low-substituted hydroxypropyl cellulose, 500 parts of 30% ethanol, 16.5 parts of magnesium stearate, 120 parts of sodium carbocisteine, 120 parts of microcrystalline cellulose, 15 parts of steviosin and 3 parts of pineapple essence.
2. The carbocisteine tablet is characterized in that the preparation process comprises the following steps:
s1, weighing: weighing the raw materials according to the weight ratio; wherein the white granulated sugar is crushed and sieved by a sieve of 80 meshes for standby; adding pineapple essence into a sprinkling can for later use;
s2, granulating: adding corn starch, pregelatinized starch, sugar powder, low-substituted hydroxypropyl cellulose and carbocisteine into a material barrel of a wet mixing granulator for dry mixing, wherein the dry mixing time is 5min, the dry mixing stirring speed is 100rpm, and the dry mixing flying knife speed is 1000 rpm; then adding 30% ethanol into a material barrel of the granulator, and carrying out wet granulation, wherein the wet mixing time is 3min, the wet mixing stirring speed is 120rpm, and the wet mixing flying cutter speed is 500 rpm; the time delay of guniting is 0s, the total time of guniting is 120s, the interval time of guniting is 0s, and the guniting time is 120 s; then starting automatic granulation to prepare a soft material, starting a discharge door, starting intermittent stirring, granulating by using a 18-mesh screen, and sucking the granules into a fluidized bed dryer through a closed pipeline;
s3, drying: starting a boiling dryer, opening an air inlet valve, an air exhaust valve and an air exhaust fan in sequence, and carrying out ventilation drying for 2 minutes at the temperature of 55-75 ℃; adjusting the air exhaust frequency to enable the material to be in a slight boiling state, manually removing dust, starting a material container discharge valve, starting a vacuum feeder, sucking dried particles into a finishing platform, closing an air exhaust fan, opening a sight glass window, and sucking residual materials in the material container into a finishing platform;
s4, finishing the grains: installing a screen with the aperture of 3mm on the granulating platform, connecting a discharge port of the granulating platform with a feed inlet of a mixing barrel filled with magnesium stearate, carboxymethyl starch sodium, pregelatinized starch, microcrystalline cellulose and stevioside, sucking dried granules into a buffer tank of the granulating platform through a vacuum feeding machine, starting a granulator, adjusting the granulating rotation speed to 80rpm, and starting granulating;
s5, total mixing: disconnecting the discharge port of the whole grain platform and the feed inlet of the mixing barrel, spraying the standby pineapple essence, sealing the feed inlet of the mixing barrel, fixing the total mixing barrel, and mixing for 25 minutes at 12 r/min. Mixing is completed;
and S6, tabletting and packaging.
3. The utility model provides a carbocisteine piece preparation equipment, includes compounding jar (3), its characterized in that: the mixing device is characterized in that reciprocating mechanisms are mounted on two sides of the mixing tank (3), a protection box (8) is mounted on the reciprocating mechanism, a cavity is arranged in the protection box (8), an automatic lifting mechanism is arranged in the cavity, a support column (4) is mounted on the automatic lifting mechanism, transverse plates (2) are fixed at the upper end of the support column (4), a protection box (14) is jointly fixed between the two transverse plates (2), grooves are formed in two sides of the upper end of the mixing tank (3), rollers (24) are arranged in the grooves in a moving mode, a buffer mechanism is connected to the upper end of each roller (24), the upper end of each buffer mechanism is connected to each transverse plate (2), two stirring devices are arranged in the protection box (14), two openings are formed in the upper end of each protection box (14), and the lower ends of the two stirring devices penetrate through the two openings and extend into the mixing tank (3, the lower end of the mixing tank (3) is connected with a discharging mechanism.
4. The carbocisteine tablet preparation equipment according to claim 3, wherein the automatic lifting mechanism comprises a screw rod (19) rotatably connected to the bottom in the cavity, the upper end of the screw rod (19) is in threaded sleeve connection with the lower end of the supporting column (4), the upper end of the supporting column (4) penetrates through the side wall of the protection box (8), sliding blocks (18) are fixed on both sides of the supporting column (4), sliding grooves (17) corresponding to the sliding blocks (18) are arranged on the opposite side walls in the cavity, the sliding blocks (18) are located in the sliding grooves (17), a first bevel gear (20) is fixedly sleeved on the screw rod (19), a servo motor (7) is installed on one side of the protection box (8), the tail end of the output shaft of the servo motor (7) penetrates through the side wall of the protection box (8) and extends into the cavity, and a second bevel gear (21) is fixed on the tail end of the output shaft of the servo motor (7), and the second bevel gear (21) and the first bevel gear (20) are meshed with each other.
5. The carbocisteine tablet preparation equipment of claim 3, characterized in that, the agitating device comprises a driving motor (13) fixed in a protective box (14), the tail end of the output shaft of the driving motor (13) is connected with an agitating rod (6) through a coupling, the agitating rod (6) passes through the corresponding opening and extends into the mixing tank (3), and a plurality of agitating blades (5) are arranged on the side wall of the circumference of the agitating rod (6) at equal intervals.
6. The carbocisteine tablet preparation equipment according to claim 3, wherein the reciprocating mechanism comprises a fixed plate (16) fixed on both sides of the mixing tank (3), a moving groove (25) is arranged on the fixed plate (16), a hydraulic cylinder (15) is installed on one side of the fixed plate (16), a moving block (9) is installed in the moving groove (25), the lower end of the protection box (8) is fixed on the upper end of the moving block (9), and the piston rod of the hydraulic cylinder (15) penetrates through the side wall of the fixed plate (16) and is fixed on one side of the moving block (9).
7. The carbocisteine tablet preparation equipment of claim 3, characterized in that, the buffer mechanism includes a connecting plate (23) fixed on the upper end of the roller (24), the upper end of the connecting plate (23) is fixed with a guide rod (1), the upper end of the guide rod (1) runs through the side wall of the transverse plate (2) and extends to the upper end of the transverse plate (2), the guide rod (1) is sleeved with a spring (22), the upper end of the spring (22) butts against the lower end of the transverse plate (2), and the lower end of the spring (22) butts against the upper end of the connecting plate (23).
8. The carbocisteine tablet preparation equipment according to claim 3, wherein the discharging mechanism comprises a discharging pipe (11) connected to the middle of the lower end of the mixing tank (3), and a valve (12) is mounted on the discharging pipe (11).
9. The carbocisteine tablet preparation equipment according to claim 3, wherein four corners of the lower end of the mixing tank (3) are all fixed with supporting legs (10), and the lower ends of the supporting legs (10) are fixed with backing plates; the length of the opening is consistent with that of the moving groove (25).
10. The carbocisteine tablet preparation equipment of claim 5, characterized in that said stirring blade (5) is provided with a plurality of projections at equal intervals.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
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| CN202010346870.XA CN111632034A (en) | 2020-04-28 | 2020-04-28 | Preparation process and equipment of carbocisteine tablets |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202010346870.XA CN111632034A (en) | 2020-04-28 | 2020-04-28 | Preparation process and equipment of carbocisteine tablets |
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| CN202010346870.XA Pending CN111632034A (en) | 2020-04-28 | 2020-04-28 | Preparation process and equipment of carbocisteine tablets |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN113566530A (en) * | 2021-08-04 | 2021-10-29 | 安仁县香火堂中药有限公司 | Environment-friendly sulfur-free drying equipment for Chinese herbal medicines |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN113566530A (en) * | 2021-08-04 | 2021-10-29 | 安仁县香火堂中药有限公司 | Environment-friendly sulfur-free drying equipment for Chinese herbal medicines |
| CN113566530B (en) * | 2021-08-04 | 2022-03-22 | 安仁县香火堂中药有限公司 | Environment-friendly sulfur-free drying equipment for Chinese herbal medicines |
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