CN111804427A - Collection structure for magnetic particles - Google Patents
Collection structure for magnetic particles Download PDFInfo
- Publication number
- CN111804427A CN111804427A CN202010725552.4A CN202010725552A CN111804427A CN 111804427 A CN111804427 A CN 111804427A CN 202010725552 A CN202010725552 A CN 202010725552A CN 111804427 A CN111804427 A CN 111804427A
- Authority
- CN
- China
- Prior art keywords
- magnetic
- magnetic block
- block
- magnetic particles
- magnetism block
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000006249 magnetic particle Substances 0.000 title claims abstract description 48
- 230000010287 polarization Effects 0.000 claims abstract description 18
- 230000007246 mechanism Effects 0.000 claims description 12
- 230000005389 magnetism Effects 0.000 claims 12
- 239000007788 liquid Substances 0.000 description 9
- 238000006243 chemical reaction Methods 0.000 description 6
- 238000009434 installation Methods 0.000 description 6
- 238000000034 method Methods 0.000 description 5
- 230000009471 action Effects 0.000 description 4
- 238000000926 separation method Methods 0.000 description 4
- 239000000427 antigen Substances 0.000 description 3
- 102000036639 antigens Human genes 0.000 description 3
- 108091007433 antigens Proteins 0.000 description 3
- 238000010586 diagram Methods 0.000 description 3
- 238000003018 immunoassay Methods 0.000 description 3
- 239000000126 substance Substances 0.000 description 3
- 238000005406 washing Methods 0.000 description 3
- 230000008859 change Effects 0.000 description 2
- 239000007795 chemical reaction product Substances 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 239000000696 magnetic material Substances 0.000 description 2
- 238000011084 recovery Methods 0.000 description 2
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 239000003446 ligand Substances 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 239000004005 microsphere Substances 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 102000039446 nucleic acids Human genes 0.000 description 1
- 108020004707 nucleic acids Proteins 0.000 description 1
- 150000007523 nucleic acids Chemical class 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 239000011541 reaction mixture Substances 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
Images
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B03—SEPARATION OF SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS; MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
- B03C—MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
- B03C1/00—Magnetic separation
- B03C1/02—Magnetic separation acting directly on the substance being separated
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B03—SEPARATION OF SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS; MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
- B03C—MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
- B03C2201/00—Details of magnetic or electrostatic separation
- B03C2201/18—Magnetic separation whereby the particles are suspended in a liquid
Landscapes
- Health & Medical Sciences (AREA)
- Immunology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Cell Biology (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Automatic Analysis And Handling Materials Therefor (AREA)
Abstract
The invention discloses a collecting structure for magnetic particles, which is characterized by comprising a pipe body, a first magnetic block body and a second magnetic block body, wherein the second magnetic block body and the first magnetic block body are adjacently arranged, the right end face of the first magnetic block body and the right end face of the second magnetic block body are respectively contacted with the pipe body or the distance between the right end face of the first magnetic block body and the pipe body is less than 2mm, the polarization direction of the first magnetic block body and the polarization direction of the second magnetic block body are opposite, the polarization direction of the first magnetic block body and the polarization direction of the second magnetic block body are both vertical to the axial direction of the pipe body, and a gap between the first magnetic block body and the second magnetic block body is parallel to the axial direction of the pipe body. According to the invention, a stronger magnetic field is generated inside the pipe body, so that magnetic particles can be collected more effectively and more stably.
Description
Technical Field
The invention belongs to the technical field of magnetic particles, and particularly relates to a collecting structure for magnetic particles.
Background
At present, many techniques such as performing various reactions in a solution using micro magnetic particles as a carrier and separating reaction products from the solution by separating magnetic microspheres have been developed, including immunoassay, a method of extracting and analyzing nucleic acids, a method of analyzing proteins or ligands, combinatorial chemistry, and the like.
For example, in various immunoassay methods widely used for detecting various early diseases or detecting trace substances, a magnetic particle technology with an antigen or an antibody is used, which provides high sensitivity and allows a simple B/F separation operation. The B/F separation means a step of separating the unreacted substance from the antigen-antibody reaction product by removing the unreacted substance from the reaction mixture in the reaction vessel and repeating a washing operation including supplying and removing a washing solution. When using magnetic particles with antigens or antibodies, the magnetic particles and the sample are mixed together to perform an antigen-antibody reaction, and then the magnetic particles containing the generated immune complexes can be rapidly collected using a magnetic force, and unreacted antigens or antibodies are separated and washed.
For these methods, increasing the recovery rate of the magnetic particles is an important issue. Although micro-magnetic particles can perform various reactions with high efficiency, micro-magnetic particles tend to be suspended in a solution, resulting in a decrease in recovery rate, and magnetic particles may be lost during washing, separation, etc., resulting in a decrease in reliability of measurement results. Especially in the case of immunoassays, multiple B/F separations are performed, which greatly affect the measured values if losses of magnetic particles occur.
The existing magnetic particle collecting device is shown in the attached figure 1 of the specification, and comprises a plurality of magnets with magnetic pole directions alternately arranged and a suction head with a liquid flow direction parallel to the arrangement direction of the magnets, wherein the alternately arranged magnets generate a magnetic field which alternately changes along the liquid flow direction in the suction head, a reaction solution in the suction head flows back and forth along the liquid flow direction in the suction head, and magnetic particles in the reaction solution are adsorbed in the wall of the suction head under the action of the magnetic field, so that the purpose of collecting the magnetic particles is achieved. However, although the peak intensity of the magnetic field generated in the suction head in the direction parallel to the surface of the magnet is strong and can reach 180mT (as shown in the attached figure 2 in the specification), the magnetic field is alternately strong and weak in the flow direction (i.e. the axial direction of the suction head), the overall magnetic field is weak, the average magnetic field is only about 90mT, the magnetic force on the magnetic particles is still insufficient, and the speed of the liquid flow needs to be reduced so as to increase the action time of the liquid flow in the magnetic field range, so that the good magnetic particle collection effect can be achieved.
Therefore, the prior art is to be improved.
Disclosure of Invention
The main objective of the present invention is to provide a collection structure for magnetic particles, which aims to solve the technical problems mentioned in the background art, a strong magnetic field is generated inside a pipe body along a direction parallel to the end face of a magnetic block, the peak intensity can reach 160mT, the variation of the magnetic field intensity along the axial direction of the pipe body is small, and the average magnetic field is about 150 mT.
The invention discloses a collecting structure for magnetic particles, which comprises a pipe body, a first magnetic block body and a second magnetic block body, wherein the second magnetic block body and the first magnetic block body are adjacently arranged, the right end face of the first magnetic block body and the right end face of the second magnetic block body are respectively contacted with the pipe body or the distance between the right end face of the first magnetic block body and the pipe body is less than 2mm, the polarization direction of the first magnetic block body and the polarization direction of the second magnetic block body are opposite, the polarization direction of the first magnetic block body and the polarization direction of the second magnetic block body are both vertical to the axial direction of the pipe body, and a gap between the first magnetic block body and the second magnetic block body is parallel to the axial direction of the pipe body.
Preferably, the thickness of the slit is 0-5 mm.
Preferably, the first magnetic block is provided with a first clearance structure on one side close to the pipe body, and the second magnetic block is provided with a second clearance structure on one side close to the pipe body.
Preferably, the first clearance structure is a first chamfer structure, a first fillet structure or a first concave structure.
Preferably, the second clearance structure is a second chamfer structure, a second fillet structure or a second concave structure.
The fixture structure comprises a magnet installation part, the moving mechanism comprises a driving mechanism, a rack provided with a guide rail and a sliding block capable of sliding on the guide rail, the sliding block is connected with the driving mechanism through a lead screw and is connected with the magnet installation part, and the magnet installation part is provided with a first positioning cavity for placing a first magnetic block and a second positioning cavity for placing a second magnetic block.
According to the collecting structure for the magnetic particles, based on the fact that the gap between the first magnetic block and the second magnetic block is parallel to the axial direction of the pipe body and the gap between the first magnetic block and the second magnetic block is in contact with the pipe body or the distance between the first magnetic block and the second magnetic block and the pipe body is less than 2mm, the first magnetic block and the second magnetic block generate a strong magnetic field in the pipe body along the direction parallel to the right end face of the magnetic block, the peak intensity can reach 160mT, the change of the magnetic field along the liquid flow direction of the pipe body is small, the average magnetic field is about 150mT, and therefore the magnetic particles in the liquid flow can be rapidly adsorbed to the inner wall of the pipe body adjacent to the magnetic block under the action of strong magnetic force pointing to the right end face direction of the magnetic block.
Drawings
FIG. 1 is a prior art magnetic particle collection apparatus of the background art;
FIG. 2 is a graph showing the magnetic field intensity distribution achieved by the prior art magnetic particle collection device of the background art;
FIG. 3 is a three-dimensional schematic of a collection structure for magnetic particles of the present invention;
FIG. 4 is a first top view of a collection structure for magnetic particles of the present invention;
FIG. 5 is a second top view of a collection structure for magnetic particles of the present invention;
fig. 6 is a schematic structural diagram of a first embodiment of a first space-avoiding structure and a second space-avoiding structure in the collecting structure for magnetic particles according to the present invention;
fig. 7 is a schematic structural diagram of a second embodiment of the first and second void-avoiding structures in the collecting structure for magnetic particles according to the present invention;
fig. 8 is a schematic structural diagram of a third embodiment of the first and second void-avoiding structures in the collecting structure for magnetic particles according to the present invention;
FIG. 9 is a magnetic field strength profile of a collection structure for magnetic particles of the present invention;
FIG. 10 is a first three-dimensional schematic view of a clamp configuration;
FIG. 11 is a second three-dimensional schematic view of the clamp configuration.
The implementation, functional features and advantages of the objects of the present invention will be further explained with reference to the accompanying drawings.
Detailed Description
It should be understood that the specific embodiments described herein are merely illustrative of the invention and are not intended to limit the invention. It is noted that relative terms such as "first," "second," and the like may be used to describe various components, but these terms are not intended to limit the components. These terms are only used to distinguish one component from another component. For example, a first element could be termed a second element, and, similarly, a second element could be termed a first element, without departing from the scope of the present invention. The term "and/or" refers to a combination of any one or more of the associated items and the descriptive items.
As shown in fig. 3, 4, 5, fig. 3 is a three-dimensional schematic view of a collection structure for magnetic particles of the present invention; FIG. 4 is a first top view of a collection structure for magnetic particles of the present invention; FIG. 5 is a second top view of a collection structure for magnetic particles of the present invention; the invention discloses a collecting structure for magnetic particles, which comprises a pipe body 10, a first magnetic block 21 and a second magnetic block 22, wherein the second magnetic block and the first magnetic block are adjacently arranged, the right end face of the first magnetic block and the right end face of the second magnetic block are respectively contacted with the pipe body or the distance between the right end face of the first magnetic block and the pipe body is less than 2mm, the polarization direction of the first magnetic block and the polarization direction of the second magnetic block are opposite, the polarization direction of the first magnetic block and the polarization direction of the second magnetic block are both vertical to the axial direction of the pipe body, and a gap 40 between the first magnetic block and the second magnetic block is parallel to the axial direction of the pipe body 10. Wherein, as shown in fig. 4, the gap 40 represents the space between the first magnetic block and the second magnetic block, which can be understood as a plane; the invention relates to a collecting structure for magnetic particles, based on that a gap between a first magnetic block and a second magnetic block is parallel to the axial direction of a pipe body and the distance between the first magnetic block and the second magnetic block and the pipe body is less than 2mm, a stronger magnetic field is generated inside the pipe body along the direction parallel to the right end face of the magnetic block only by utilizing the first magnetic block and the second magnetic block, the peak intensity can reach 160mT, the change of the magnetic field along the liquid flow direction of the pipe body is very small, the average magnetic field is about 150mT (as shown in figure 9), the magnetic field intensity is gradually reduced outwards along the direction vertical to the right end face of the magnetic block, the magnetic force direction of the magnetic particles in the magnetic field is vertical to the magnetic field direction, and the weak magnetic field points to the strong magnetic field, so that the magnetic particles in the liquid flow along the pipe body can be rapidly adsorbed to the inner wall of the pipe body adjacent to the magnetic block under the action of the, the effect of collecting magnetic particles is achieved.
The polarization direction of the first magnetic block body refers to the direction in which the N pole points to the S pole; the polarization direction of the second magnetic block means a direction in which the N-pole points to the S-pole.
Here, the axial direction of the pipe body represents a vertically upward direction X or a vertically downward direction Y.
Wherein the first magnetic block represents a block structure made of a magnetic material; the second magnetic block represents a block structure made of a magnetic material; the first magnetic block 21 is close to the pipe 10 and has been seted up first keep away empty structure 51 and shows that the first magnetic block 21 is close to the terminal surface of pipe 10 one side and has been seted up first keep away empty structure 51, and first keep away empty structure can be first chamfer structure, first fillet structure or first indent structure. Similarly, the second magnetic block is provided with a second clearance structure 52 near one side of the pipe body 10, and the second clearance structure may be a second chamfer structure, a second fillet structure or a second concave structure.
As shown in fig. 6, when the first clearance structure is a first chamfer structure, the second clearance structure is a second chamfer structure; as shown in fig. 7, when the first clearance structure is a first round angle structure, the second clearance structure is a second round angle structure; as shown in fig. 8, when the first void-avoiding structure is a first concave structure, the second void-avoiding structure is a second concave structure.
Preferably, the thickness of the slit is 0-5mm, as shown in fig. 4. (ii) a For example, the magnetic field strength generated when the gap thickness is 2mm is greater than the magnetic field strength generated when the gap thickness is 0 mm. Specifically, as shown in fig. 10 and 11, the magnetic chuck further includes a clamp structure and a moving mechanism for driving the clamp structure to move, the clamp structure includes a magnet installation portion 501, the moving mechanism includes a driving mechanism 500, a frame 502 provided with a guide rail 505, and a slider 503 capable of sliding on the guide rail 505, the slider 503 is connected with the driving mechanism 500 through a lead screw 504, the slider 503 is connected with the magnet installation portion 501, and the magnet installation portion 501 is provided with a first positioning cavity for placing the first magnetic block 21 and a second positioning cavity for placing the second magnetic block 22. The magnet mounting part 501 is arranged based on two positioning cavities, so that a gap between the first magnetic block and the second magnetic block reaches 0-5 mm; so as to realize stable and efficient collection of the micro-magnetic particles. The moving mechanism is arranged in the instrument and plays a role in stably driving the clamp structure to move, and the right end face of the first magnetic block and the right end face of the second magnetic block are respectively in contact with the tube body or have a distance smaller than 2mm with the tube body.
The above description is only a preferred embodiment of the present invention, and not intended to limit the scope of the present invention, and all modifications of equivalent structures and equivalent processes, which are made by using the contents of the present specification and the accompanying drawings, or directly or indirectly applied to other related technical fields, are included in the scope of the present invention.
Claims (6)
1. The utility model provides a collect structure for magnetic particle, a serial communication port, including the body, first magnetism block and second magnetism block, second magnetism block and first magnetism block adjacent row, first magnetism block right-hand member face and second magnetism block right-hand member face respectively with the body contact or with the body between the distance be less than 2mm, the polarization direction of first magnetism block and the polarization direction of second magnetism block are opposite, the polarization direction of first magnetism block and the polarization direction of second magnetism block all are perpendicular with the axis direction of body, the gap between first magnetism block and the second magnetism block is parallel with the axis direction of body.
2. A collecting structure for magnetic particles according to claim 1, wherein the thickness of the slit is 0 to 5 mm.
3. The collecting structure of claim 1, wherein the first magnetic block has a first space-avoiding structure disposed on a side thereof adjacent to the tube, and the second magnetic block has a second space-avoiding structure disposed on a side thereof adjacent to the tube.
4. A collecting structure for magnetic particles according to claim 3, wherein the first space-avoiding structure is a first chamfer structure, a first fillet structure or a first concave structure.
5. A collecting structure for magnetic particles according to claim 4, wherein the second clearance structure is a second fillet structure, a second fillet structure or a second concave structure.
6. The collecting structure for magnetic particles according to claim 1, further comprising a clamp structure and a moving mechanism for moving the clamp structure, wherein the clamp structure comprises a magnet mounting portion, the moving mechanism comprises a driving mechanism, a frame provided with a guide rail, and a slider capable of sliding on the guide rail, the slider is connected with the driving mechanism through a lead screw, the slider is connected with the magnet mounting portion, and the magnet mounting portion is provided with a first positioning cavity for placing the first magnetic block and a second positioning cavity for placing the second magnetic block.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202010725552.4A CN111804427A (en) | 2020-07-24 | 2020-07-24 | Collection structure for magnetic particles |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202010725552.4A CN111804427A (en) | 2020-07-24 | 2020-07-24 | Collection structure for magnetic particles |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN111804427A true CN111804427A (en) | 2020-10-23 |
Family
ID=72861541
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202010725552.4A Pending CN111804427A (en) | 2020-07-24 | 2020-07-24 | Collection structure for magnetic particles |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN111804427A (en) |
Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1735806A (en) * | 2002-11-07 | 2006-02-15 | 株式会社三菱化学药得论 | Magnetic material for collecting magnetic particles and utilization thereof |
| CN203663997U (en) * | 2014-01-07 | 2014-06-25 | 上海科华生物工程股份有限公司 | Magnetic separation device |
| CN105185504A (en) * | 2015-08-14 | 2015-12-23 | 上海白泽医疗器械有限公司 | Flow sorting device for cell beads |
| CN106754352A (en) * | 2017-03-14 | 2017-05-31 | 复旦大学附属中山医院 | A kind of disposable de- magnetic sorting apparatus and its method for separating |
| CN107530486A (en) * | 2015-05-08 | 2018-01-02 | 生物磁溶液有限公司 | The apparatus and method of immunomagnetic cell separation |
| KR101934671B1 (en) * | 2018-04-30 | 2019-01-02 | 중앙대학교 산학협력단 | Apparatus for sparating magnetic particles |
| CN212856165U (en) * | 2020-07-24 | 2021-04-02 | 深圳沃德生命科技有限公司 | Collection structure for magnetic particles |
-
2020
- 2020-07-24 CN CN202010725552.4A patent/CN111804427A/en active Pending
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1735806A (en) * | 2002-11-07 | 2006-02-15 | 株式会社三菱化学药得论 | Magnetic material for collecting magnetic particles and utilization thereof |
| CN203663997U (en) * | 2014-01-07 | 2014-06-25 | 上海科华生物工程股份有限公司 | Magnetic separation device |
| CN107530486A (en) * | 2015-05-08 | 2018-01-02 | 生物磁溶液有限公司 | The apparatus and method of immunomagnetic cell separation |
| CN105185504A (en) * | 2015-08-14 | 2015-12-23 | 上海白泽医疗器械有限公司 | Flow sorting device for cell beads |
| CN106754352A (en) * | 2017-03-14 | 2017-05-31 | 复旦大学附属中山医院 | A kind of disposable de- magnetic sorting apparatus and its method for separating |
| KR101934671B1 (en) * | 2018-04-30 | 2019-01-02 | 중앙대학교 산학협력단 | Apparatus for sparating magnetic particles |
| CN212856165U (en) * | 2020-07-24 | 2021-04-02 | 深圳沃德生命科技有限公司 | Collection structure for magnetic particles |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| Pamme et al. | Continuous sorting of magnetic cells via on-chip free-flow magnetophoresis | |
| US9885642B2 (en) | Devices and methods for separating magnetically labeled moieties in a sample | |
| EP2167216B1 (en) | Density-based methods for separation of materials, monitoring of solid supported reactions and measuring densities of small liquid volumes and solids | |
| Zborowski et al. | Rare cell separation and analysis by magnetic sorting | |
| Han et al. | Paramagnetic capture mode magnetophoretic microseparator for high efficiency blood cell separations | |
| Ramadan et al. | Magnetic-based microfluidic platform for biomolecular separation | |
| US20070202536A1 (en) | Methods and compositions for separating rare cells from fluid samples | |
| EP1964613A2 (en) | Magnetic separator and analyzer using the same | |
| CA2264389A1 (en) | A micro flow system for particle separation and analysis | |
| Hettiarachchi et al. | Recent microfluidic advances in submicron to nanoparticle manipulation and separation | |
| EP1776449A2 (en) | Magnetic device for isolation of cells and biomolecules in a microfluidic environment | |
| CN106378216B (en) | A kind of particulate sorter based on negative magnetophoresis technology | |
| KR20050044559A (en) | Method for detecting analyte(s) using magnetic colloidal particles | |
| WO2011001646A1 (en) | Magnetic particle transfer device and magnetic particle transfer method | |
| EP1331035A1 (en) | Apparatus for retaining magnetic particles within a flow-through cell | |
| US20220080423A1 (en) | System, Fluidics Cartridge, and Methods for Using Actuated Surface-Attached Posts for Processing Cells | |
| Darabi et al. | On-chip magnetophoretic isolation of CD4+ T cells from blood | |
| Han et al. | Lateral dielectrophoretic microseparators to measure the size distribution of blood cells | |
| CN110514855A (en) | It is a kind of to change liquid method, changing liquid plate and its purposes in cell dyeing and particle washing | |
| CN212856165U (en) | Collection structure for magnetic particles | |
| Yang et al. | A novel rare cell sorting microfluidic chip based on magnetic nanoparticle labels | |
| Telleman et al. | Cell sorting in microfluidic systems | |
| CN111804427A (en) | Collection structure for magnetic particles | |
| Guler et al. | A simple approach for the fabrication of 3D microelectrodes for impedimetric sensing | |
| WO2021245635A1 (en) | Dielectrophoresis detection device |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination |