CN111803794A

CN111803794A - Wearable electric field applying device

Info

Publication number: CN111803794A
Application number: CN202010886897.8A
Authority: CN
Inventors: 陈亮; 周波; 于晶; 黄勇
Original assignee: Jiangsu Hailai Xinchuang Medical Technology Co Ltd
Current assignee: Jiangsu Hailai Xinchuang Medical Technology Co Ltd
Priority date: 2020-08-28
Filing date: 2020-08-28
Publication date: 2020-10-23

Abstract

The invention provides a wearable electric field applying device, comprising: the electrode plates comprise a first flexible substrate, a flexible circuit board arranged on the first flexible substrate and a joint buffer layer arranged on the surface of the flexible circuit board; the flexible conductive connecting part is used for connecting the electrode plates and comprises a second flexible substrate and a lead embedded into the second flexible substrate, and the lead is of a structure capable of stretching and rebounding along the length direction; and the leads in the flexible conductive connecting part are connected with the flexible circuit board conductors of the electrode plates, and a plurality of parallel circuits can be formed after the flexible circuit board conductors are electrified.

Description

Wearable electric field applying device

Technical Field

The invention relates to the field of wearable devices, medical instruments and health care instruments, in particular to a flexible electric field treatment electrode and a wearable device, which are used for applying an electric field to a living body.

Background

The tumor treating electric field is one low strength, medium frequency and alternating electric field and can treat tumor via interfering the mitosis process of tumor cell. Research shows that the tumor electric field treatment method has obvious effect in treating tumors such as glioblastoma, non-small cell lung cancer, melanoma and the like, can prolong the life of a patient, and has small side effect.

Wearable intelligent products are high-tech products which are gradually heated in recent years along with the popularity of smart phones and smart tablet computers. The miniature electronic computer and the electronic sensor are woven together with the plant fiber to be woven into the wearable textile such as clothes, gloves, hats, shoes and the like. Due to the novelty, intellectualization and high interactivity with human bodies, the method arouses great interest of people. The tumor treatment electric field is applied to the tissue region where the tumor is located through an external electrode, and the electric field is applied to the tumor in a capacitive coupling mode. The tumor treatment electric field electrode is applied to the surface of the skin of a patient, and the patient is treated for a long time. In order not to affect the work, life and entertainment of patients, the electric field electrode is combined with a wearable device to be a feasible method.

The defects of the current wearable device applied to the electric field treatment electrode are as follows:

1. the flexible circuit and the wearable fabric are made of different materials, the surface bonding force of the flexible circuit and the wearable fabric is poor, the flexible circuit and the wearable fabric are easy to dislocate when being stretched or kneaded, and the flexible circuit and the wearable fabric are separated;

2. the flexible circuit has poor contact with the skin, and the electric field treatment effect can be influenced because the circuit is applied to the skin unstably;

3. the electric field electrode for tumor treatment needs to treat a human body for a long time, and the traditional wearable electrode has poor air permeability and can cause red and swollen skin surface and allergy.

The statements in the background section are merely prior art as they are known to the inventors and do not, of course, represent prior art in the field.

Disclosure of Invention

To address one or more of the problems with the prior art, the present invention provides a wearable electric field application device, comprising:

the electrode plates comprise a first flexible substrate, a flexible circuit board arranged on the first flexible substrate and a joint buffer layer arranged on the surface of the flexible circuit board;

the flexible conductive connecting part is used for connecting the electrode plates and comprises a second flexible substrate and a lead embedded into the second flexible substrate, and the lead is of a structure capable of stretching and rebounding along the length direction;

and the leads in the flexible conductive connecting part are connected with the flexible circuit board conductors of the electrode plates, and a plurality of parallel circuits can be formed after the flexible circuit board conductors are electrified.

According to an aspect of the invention, the plurality of electrodes may constitute a plurality of electrode pairs, and each of the electrode pairs may be symmetrically disposed on the surface applied to the substrate.

According to one aspect of the invention, the plurality of parallel circuits comprise a first main circuit, a plurality of first branch circuits connected with the first main circuit, a second main circuit and a plurality of second branch circuits connected with the second main circuit, the end point of each first branch circuit or each second branch circuit is connected with an electrode plate, and the end heads of the first main circuit and the second main circuit are used for being connected with a power supply.

According to one aspect of the present invention, the number of electrode pads connected to the first branch circuits is the same as the number of electrode pads connected to the second branch circuits, and a plurality of electrode pairs are formed.

According to one aspect of the invention, the plurality of electrode sheets are arranged in a regular array, so that after the electrode sheets are applied to a human body, the electrode sheets are opposite to each other.

According to one aspect of the invention, the wires exhibit a wave-like structure along the length direction within the second flexible substrate.

According to an aspect of the present invention, the flexible conductive connecting portion has a band shape, which is wavy in a length direction.

According to one aspect of the present invention, the flexible conductive connecting portion has a disk shape or a nearly disk shape, and a cross section thereof in any direction is wavy.

According to one aspect of the invention, the flexible electrode sheet is in a shape of a circular sheet or a square with rounded corners.

According to one aspect of the invention, the surface of the attaching buffer layer of the flexible electrode plate is provided with a removable protective layer.

According to one aspect of the invention, the surface of the flexible conductive connecting part is provided with a removable protective layer.

Further, an open space is formed between the protective layer and the wavy flexible conductive connecting part.

According to one aspect of the invention, the flexible conductive connecting part is connected with the plurality of electrode plates to form a grid-shaped wearable electric field applying device, the grid-shaped wearable electric field applying device comprises an electrode plate attaching area and a ventilation area, the electrode plate attaching area is an area covered by the electrode plates in the wearable electric field applying device and an area where the flexible electric connecting belt is attached to the applying surface, and the ventilation area is an area uncovered by the electrode plates in the wearable electric field applying device and an area where the flexible electric connecting belt is not attached to the applying surface; the breathable zone surrounds the attachment zone.

Preferably, the breathable zone is 0.2 to 2 times, preferably 1.5 to 1.8 times, the conformable zone.

According to one aspect of the invention, the flexible conductive connecting portion is connected with the electrode plates to form a soft-grip wearable electric field applying device, such as a claw shape or a petal shape; the wearable electric field applying device in the shape of the soft hand grip comprises a center and an even number of hand grips, and the electrode plates are connected with the hand grip conductors.

According to one aspect of the invention, the flexible conductive connecting part is connected with the electrode plates to form an annular wearable electric field applying device.

According to one aspect of the invention, the first flexible substrate and the second flexible substrate are both one or a combination of more than two of hydrogel, Polydimethylsiloxane (PDMS), liquid silicon rubber, polyurethane film and acrylic adhesive.

According to one aspect of the invention, the conformable buffer layer comprises a dielectric and a conductive component dispersed in the dielectric, wherein the conformable buffer layer has an impedance of less than or equal to 200 ohms for a 1 inch by 1mm volume of alternating current at 200 KHz; preferably 15-30 ohms.

According to one aspect of the invention, the medium is one or a combination of more than two of hydrogel, polydimethylsiloxane PDMS and liquid silicone rubber.

According to one aspect of the invention, the conductive component is one or a combination of more than two of sodium salt, potassium salt, silver wire, graphene and carbon nano tube.

According to one aspect of the invention, the thickness of the conformable buffer layer is 0.4-1.5mm, preferably 0.5-1 mm.

According to one aspect of the invention, the conformable buffer layer is grade 0,1 or 2 cytotoxic.

According to the invention, through the design of the structural relationship between the electrode plate and the flexible conductive connecting part, the flexible conductive connecting part can be more flexibly applied to a human body. The arrangement of the laminating buffer layer can not only enhance the flexibility, but also ensure that the bonding force of the electrode plate and the skin surface is matched and the electrode plate is not easy to fall off; meanwhile, the design of the invention leads the surface of the skin to be ventilated, allows sweat to overflow through the ventilation interval and reduces the red swelling and allergy of the skin of a patient.

Drawings

The accompanying drawings, which are included to provide a further understanding of the invention and are incorporated in and constitute a part of this specification, illustrate embodiments of the invention and together with the description serve to explain the principles of the invention and not to limit the invention. In the drawings:

fig. 1 is a schematic structural view (mesh shape) of the wearable electric field application device of embodiment 1;

fig. 2 is a schematic cross-sectional view of the electrode sheet 100 in the schematic structural view of the wearable electric field application device in embodiment 1;

fig. 3 is another schematic cross-sectional view of the electrode sheet 100 in the structural schematic view of the wearable electric field application device in embodiment 1;

FIG. 4 is a schematic cross-sectional view of the flexible conductive connecting portion 200 in the structural schematic view of the wearable electric field application device in example 1;

fig. 5 is another schematic cross-sectional view of the flexible conductive connection part 200 in the structural schematic view of the wearable electric field application device in embodiment 1;

fig. 6 is a schematic structural view (mesh-like) of another wearable electric field application device shown in embodiment 1;

fig. 7 is a schematic structural view (mesh-like) of another wearable electric field application device shown in embodiment 1;

fig. 8 is a schematic structural view (mesh-like) of another wearable electric field application device shown in embodiment 1;

fig. 9 is a schematic structural view (hand grip shape) of a wearable electric field application device shown in embodiment 2;

fig. 10 is a schematic structural view (ring shape) of a wearable electric field application device shown in embodiment 2.

Detailed Description

In the following, only certain exemplary embodiments are briefly described. As those skilled in the art will recognize, the described embodiments may be modified in various different ways, all without departing from the spirit or scope of the present invention. Accordingly, the drawings and description are to be regarded as illustrative in nature, and not as restrictive.

In the description of the present invention, it is to be understood that the terms "center", "longitudinal", "lateral", "length", "width", "thickness", "upper", "lower", "front", "rear", "left", "right", "vertical", "horizontal", "top", "bottom", "inner", "outer", "clockwise", "counterclockwise", and the like, indicate orientations and positional relationships based on those shown in the drawings, and are used only for convenience of description and simplicity of description, and do not indicate or imply that the device or element being referred to must have a particular orientation, be constructed and operated in a particular orientation, and thus, should not be considered as limiting the present invention. Furthermore, the terms "first", "second" and "first" are used for descriptive purposes only and are not to be construed as indicating or implying relative importance or implicitly indicating the number of technical features indicated. Thus, features defined as "first", "second", may explicitly or implicitly include one or more of the described features. In the description of the present invention, "a plurality" means two or more unless specifically defined otherwise.

In the description of the present invention, it should be noted that unless otherwise explicitly stated or limited, the terms "mounted," "connected," and "connected" are to be construed broadly, e.g., as meaning either a fixed connection, a removable connection, or an integral connection, either mechanically, electrically, or in communication with each other; either directly or indirectly through intervening media, either internally or in any other relationship. The specific meanings of the above terms in the present invention can be understood by those skilled in the art according to specific situations.

In the present invention, unless otherwise expressly stated or limited, "above" or "below" a first feature means that the first and second features are in direct contact, or that the first and second features are not in direct contact but are in contact with each other via another feature therebetween. Also, the first feature being "on," "above" and "over" the second feature includes the first feature being directly on and obliquely above the second feature, or merely indicating that the first feature is at a higher level than the second feature. A first feature being "under," "below," and "beneath" a second feature includes the first feature being directly above and obliquely above the second feature, or simply meaning that the first feature is at a lesser level than the second feature.

The following disclosure provides many different embodiments or examples for implementing different features of the invention. To simplify the disclosure of the present invention, the components and arrangements of specific examples are described below. Of course, they are merely examples and are not intended to limit the present invention. Furthermore, the present invention may repeat reference numerals and/or letters in the various examples, such repetition is for the purpose of simplicity and clarity and does not in itself dictate a relationship between the various embodiments and/or configurations discussed. In addition, the present invention provides examples of various specific processes and materials, but one of ordinary skill in the art may recognize applications of other processes and/or uses of other materials.

The preferred embodiments of the present invention will be described in conjunction with the accompanying drawings, and it will be understood that they are described herein for the purpose of illustration and explanation and not limitation.

Example 1:

as shown in fig. 1-5, a first embodiment of the present invention provides a wearable electric field applying apparatus, as shown in fig. 1, the wearable electric field applying apparatus is in a grid-like structure, and can be applied to the head, back and abdomen of a human body in general, for applying an electric field effect to a tumor of the human body or other animal bodies. The method comprises the following steps: a plurality of electrode plates 100 for connecting the flexible conductive connection parts 200 of the plurality of electrode plates. The grid-shaped wearable electric field applying device comprises a fitting area and a ventilation area, wherein the fitting area is an area covered by an electrode plate in the wearable electric field applying device and an area where the flexible electric connecting belt is fitted with the applying surface, and the ventilation area is an area uncovered by the electrode plate in the wearable electric field applying device and a non-fitting area of the flexible electric connecting belt and the applying surface; the breathable zone surrounds the attachment zone. The arrangement of the ventilation area enables the heat applied on the surface to be evacuated instantly, and the human body feels milder without stimulation. Through clinical research, the ventilation area is preferably 0.2-2 times, and most preferably 1.5-1.8 times of the attaching area.

The components of the wearable electric field application device are specifically described below.

Fig. 2 shows a schematic cross-sectional view of the electrode sheet 100. The electrode sheet 100 is a terminal part of a wearable electric field applying apparatus for applying an electric field to a human body or other animal body, and is required to be attached to a skin surface. The electrode sheet can be in a circular sheet shape or a square shape with four rounded corners, and the electrode sheet can be set into other shapes according to the needs of the person skilled in the art. For example, the electrode sheet of the wearable electric field application device shown in fig. 1 is circular, the electrode sheet of the wearable electric field application device shown in fig. 6 is square, and the shape of the electrode sheet 100 depends on the comfort requirement and the grid design of the application design. In the present invention, the circuit design limited by the electrode plate is generally circular sheet or square. The electrode sheet 100 includes a first flexible substrate 101, a flexible circuit board 102 provided on the first flexible substrate, and a lamination buffer layer 103 provided on a surface of the flexible circuit board. The flexible circuit board 102 may be an FPC flexible circuit board, and the conductor of the FPC flexible circuit board may be a copper foil, silver paste, or the like. The first flexible substrate 101 and the flexible circuit board 102 may be bonded together or may be attached together in other ways commonly used by those skilled in the art. The conformable buffer layer 103 includes a dielectric and a conductive component dispersed in the dielectric, and has an impedance of less than or equal to 200 ohms, preferably 15-30 ohms, for a 1 inch by 1mm volume of the conformable buffer layer when subjected to an alternating current of 200 KHz. The medium is one or the combination of more than two of hydrogel, polydimethylsiloxane PDMS and liquid silicon rubber; the conductive component adopts one or the combination of more than two of sodium salt, sylvite, silver wire, graphene and carbon nano tube. The thickness of the attaching buffer layer is 0.4-1.5mm, preferably 0.5-1 mm. The cytotoxicity of the bonding buffer layer is 0,1 or 2 grade, and the requirement of United states pharmacopoeia is met. The invention can adjust the content of the conductive component in the bonding buffer layer to ensure that the impedance of the bonding buffer layer meets the requirement. According to research, the test conditions are as follows: when alternating current is 200KHz, the electric field can meet the treatment intensity when the impedance of the attached buffer layer with the volume of 1 inch by 1mm is less than 200 ohms. The electrode plates are regularly arranged in an array, so that the electrode plates are opposite to each other after being applied to a human body; the plurality of electrodes may form a plurality of electrode pairs, and each of the electrode pairs may be symmetrically disposed on a surface to which the substrate is applied. The two electrode plates are electrified to generate an electric field, the electrode plates are attached to the position of the outer skin of the body, the electric field is applied to the tissue area where the tumor is located, and the electric field is applied to the tumor area in a capacitive coupling mode. The electric field is applied to the body or tissue by means of the conductive electrode, the output medium frequency electric field acts on the body or tissue, and the tumor cells are influenced by the medium frequency electric field. The frequency of the alternating electric field can be controlled to interfere the movement of charged particles and polarized molecules in cells in the mitosis process of tumor cells, so that the internal structures of some tumor cells cannot be normally formed, even the cell membranes of the tumor cells are broken, and the apoptosis of the cells in the mitosis phase is induced, thereby realizing the purpose of treating the tumor.

As shown in fig. 3, a protective layer 51 which can be removed by peeling is preferably provided on the surface of the adhesive buffer layer 103. When not in use, the protective layer 51 can be bonded to the surface of the bonding buffer layer 103, thereby preventing the bonding buffer layer 103 from being contaminated.

Fig. 4 shows a flexible conductive connection portion 200 for connecting several electrode pads 100 to supply current to several electrode pads 100. The flexible conductive connecting portion 200 is a strip, also called a flexible conductive connecting band, which is also called a grid wire in this embodiment. The flexible conductive connection strip 200 includes a second flexible substrate 201 and a conductive line 202 embedded within the second flexible substrate. The wearable electric field application device with the grid-shaped structure is mainly formed by the shape design of the grid formed by the flexible conductive connecting belt 200. The flexible conductive connecting band 200 is made into a grid-shaped (or named as a checkerboard-shaped) structure, the flexible circuit board 102 in the electrode plate 100 is connected with the conductor 202 in the flexible conductive connecting band 200, and a plurality of parallel circuits can be formed after the flexible conductive connecting band is electrified. When the wearable electric field applying device is used, the flexible conductive connecting band 200 is flexible, the grid-shaped wearable electric field applying device is like a fabric, the electrode plates 100 arranged on the flexible conductive connecting band 200 can be freely attached according to the shape and the characteristics of an applied base body (such as a human body), meanwhile, the air permeability of the wearable electric field applying device is kept, and the body feeling is more comfortable. The plurality of parallel circuits comprise a first main circuit, a plurality of first branch circuits connected with the first main circuit, a second main circuit and a plurality of second branch circuits connected with the second main circuit, the end point of each first branch circuit or each second branch circuit is connected with an electrode plate, and the end heads of the first main circuit and the second main circuit are used for being connected with a power supply; the number of the electrode plates connected with the first branch circuits is the same as that of the electrode plates connected with the second branch circuits, and a plurality of electrode pairs are formed. The wearable electric field applying device with the grid-shaped structure can adopt one piece of the wearable electric field applying device with the grid-shaped structure to realize the formation of the parallel circuit through the design of internal conducting wires, and can also adopt two pieces of the wearable electric field applying devices with the grid-shaped structure to realize the formation of the parallel circuit together. As shown in fig. 6 and 8, when the wearable electric field application device with the grid-shaped structure shown in fig. 6 and 8 is used, and the power supply leads 1 are connected with the power supply, so that the current realizes the formation of the circuit through the design of the wires 202 in the flexible conductive connection band 200. The circuit requirements can be met by the skilled person through the prior art. As shown in fig. 7, two wearable electric field applying apparatuses with a grid structure are provided, and the power supply leads 1A and 1B are connected to the positive and negative electrodes of the power supply, respectively, so that the parallel circuit can be also used.

As shown in fig. 4, the wire 202 is in a stretch resilient configuration along its length. For example, the wire 202 is made into a wavy structure along the length direction, and the waves can be pulled to form a straight line when the wire needs to be stretched along the length direction, and can rebound to form waves when the distance needs to be reduced. Meanwhile, as a preferable mode, the whole of the flexible conductive connecting band 200 formed by the second flexible substrate 201 and the conducting wire 202 has a structure capable of stretching and rebounding along the length direction, for example, the whole is made into a wave-shaped structure. The wire 202 may be formed of a variety of conductive materials as will be appreciated by those skilled in the art. For example: a plurality of strands of copper core wires can be adopted, 20-30 copper core wires exist on the section of 1.0 square millimeter, and the copper core wire is mainly used in places which need to be bent excessively and move frequently; the carbon-based wire can also be adopted, for example, the wire core consisting of graphene is coated with a copper coating, so that the conductive performance of the wire can be enhanced, the weight of the wire can be reduced, and the flexibility of the wire can be improved on the premise of not influencing the welding performance of the wire.

As a preferable scheme of the flexible conductive connecting band 200, as shown in fig. 5, a removable protective layer 52 is disposed on one surface of the flexible conductive connecting band 200 for adhering to the surface of the applied substrate, so as to protect the cleanness of the adhering surface, facilitate repeated use and prolong the service life. When the flexible conductive connecting band 200 is in a stretchable and resilient structure with a wave shape along the length direction, an open space 53 is formed between the protection layer 52 and the flexible conductive connecting band 200 with a wave shape.

In this embodiment, the first flexible substrate 101 and the second flexible substrate 201 both adopt one or a combination of two or more of hydrogel, polydimethylsiloxane PDMS, liquid silicone rubber, a polyurethane film, and an acrylic adhesive. The first flexible substrate 101 and the second flexible substrate 201 may be an integral layer, or may be made into a flexible conductive connection portion or an electrode sheet, respectively. When the first flexible substrate 101 and the second flexible substrate 201 may be an integral layer, according to the arrangement design of the electrodes, the flexible substrate surface at the position where the electrodes are disposed is selected to manufacture the flexible circuit board and the bonding buffer layer, so as to form the electrode sheet 100, and the positions of the other flexible substrates are manufactured into the wires embedded in the flexible substrate according to the design of the circuit, so as to form the flexible conductive connection portion. The protective layers 51 and 52 may be separate members or may be an integral layer covering the surface of the electric field application device that is in contact with the surface of the application substrate (e.g., human body).

Example 2:

this embodiment provides a wearable electric field applying apparatus, as shown in fig. 9, the wearable electric field applying apparatus is in a soft hand-grip structure. The method comprises the following steps: a plurality of electrode plates 100 for connecting the flexible conductive connection parts 200 of the plurality of electrode plates. The electrode sheet 100 has a sheet-like shape as in example 1, and in this example, the electrode sheet 100 has a long sheet-like shape. The flexible conductive connection portion 200 is shaped like a circular disc, and the cross-sectional view of the circular disc in any direction is wavy, and looks like "ripples" outward from the center of the circular disc. The internal structure is substantially the same as that of embodiment 1, that is, the structure includes a second flexible substrate 201 and a wire 202 embedded in the second flexible substrate. According to the requirements of circuit design, a person skilled in the art lays a conductive line 202 in a formed disc-shaped second flexible substrate 201 with "ripples", the conductive line 202 is attached to the inside of the second flexible substrate 201, and the second flexible substrate 201 fluctuates along with the fluctuations. This process of routing wires is prior art in the field and this embodiment is not reiterated. The electrode plates 100 are soft-grip-shaped structures, and the flexible circuit boards 102 of the electrode plates 100 are connected with the leads 202 arranged in the disc-shaped flexible lead connecting parts 200. The wearable electric field applying device with soft hand grip shape shown in this embodiment is more suitable for the head position, and the wafer-shaped flexible conductive connection portion 200 with ripples can be deformed and stretched according to the arrangement position requirement of the electrodes.

Example 3:

in the wearable electric field applying device according to the present embodiment, as shown in fig. 10, the flexible conductive connecting portion 200 is connected to the electrode sheets 100 to form a ring-shaped wearable electric field applying device. The electric field applying device with the structural characteristics is used for matching the head of a human body and is used for drying.

Finally, it should be noted that: although the present invention has been described in detail with reference to the foregoing embodiments, it will be apparent to those skilled in the art that changes may be made in the embodiments and/or equivalents thereof without departing from the spirit and scope of the invention. Any modification, equivalent replacement, or improvement made within the spirit and principle of the present invention should be included in the protection scope of the present invention.

Claims

1. A wearable electric field application device, comprising:

2. The wearable electric field application device of claim 1, wherein the plurality of electrodes form a plurality of electrode pairs, each electrode pair being symmetrically disposed on the surface of the substrate;

preferably, the plurality of parallel circuits comprise a first main circuit, a plurality of first branch circuits connected with the first main circuit, a second main circuit and a plurality of second branch circuits connected with the second main circuit, the end point of each first branch circuit or each second branch circuit is connected with an electrode plate, and the end points of the first main circuit and the second main circuit are used for connecting a power supply;

preferably, the number of the electrode plates connected with the first branch circuits is the same as that of the electrode plates connected with the second branch circuits, and a plurality of electrode pairs are formed;

preferably, the electrode plates are regularly arranged in an array, so that the electrode plates are opposite to each other after being applied to a human body.

3. The wearable electric field application device of claim 1, wherein the conductive wire exhibits a wave-like structure along a length direction within the second flexible substrate;

preferably, the flexible conductive connecting part is in a strip shape, and the flexible conductive connecting part is wavy along the length direction;

preferably, the flexible conductive connecting part is in a disc shape or a nearly disc shape, and the cross section of the flexible conductive connecting part along any direction is in a wave shape.

4. The wearable electric field application device of claim 1, wherein the flexible electrode sheet is a circular sheet or a square with rounded corners.

5. The wearable electric field application device of any of claims 1-4, wherein a removable protective layer is provided on a surface of the conformable buffer layer of the flexible electrode sheet;

preferably, the surface of the flexible conductive connecting part is provided with a removable protective layer; further preferably, the protective layer and the wavy flexible conductive connecting portion have an open space therebetween.

6. The wearable electric field application device of any one of claims 1-4, wherein the flexible conductive connection portion is connected with the plurality of electrode pads to form a grid-shaped wearable electric field application device, the grid-shaped wearable electric field application device comprises a fit region and a ventilation region, the fit region is a region covered by the electrode pads in the wearable electric field application device and a region where the flexible electric connection band is fitted to the application surface, and the ventilation region is a region uncovered by the electrode pads in the wearable electric field application device and a region where the flexible electric connection band is not fitted to the application surface; the breathable zone surrounds the fit zone;

7. The wearable electric field application device of any of claims 1-4, wherein the flexible conductive connection is connected to the plurality of electrode pads to form a soft grip-shaped wearable electric field application device, such as claws or petals; the wearable electric field applying device in the shape of the soft hand grip comprises a center and an even number of hand grips, and the electrode plates are connected with the hand grip conductors.

8. The wearable electric field application device of claim 6, wherein the flexible conductive connection portion is connected to the plurality of electrode pads to form a ring-shaped wearable electric field application device.

9. The wearable electric field application device of claim 1, wherein the first and second flexible substrates each employ one or a combination of two or more of hydrogel, Polydimethylsiloxane (PDMS), liquid silicone rubber, polyurethane film, and acrylic adhesive.

10. The wearable electric field application device of claim 1, wherein the conformable buffer layer comprises a dielectric and a conductive component dispersed in the dielectric, and has an impedance of 200 ohms, preferably 15-30 ohms, for a volume of 1 inch by 1mm of the conformable buffer layer when subjected to an alternating current of 200 KHz;

preferably, the medium is one or a combination of more than two of hydrogel, Polydimethylsiloxane (PDMS) and liquid silicone rubber;

preferably, the conductive component adopts one or a combination of more than two of sodium salt, potassium salt, silver wire, graphene and carbon nano tube;

preferably, the thickness of the attaching buffer layer is 0.4-1.5mm, preferably 0.5-1 mm;

preferably, the conformable buffer layer is grade 0,1 or 2 cytotoxic.