CN111803244A - Bone filling block with tantalum metal porous structure layer, manufacturing method and application - Google Patents
Bone filling block with tantalum metal porous structure layer, manufacturing method and application Download PDFInfo
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- CN111803244A CN111803244A CN202010598820.0A CN202010598820A CN111803244A CN 111803244 A CN111803244 A CN 111803244A CN 202010598820 A CN202010598820 A CN 202010598820A CN 111803244 A CN111803244 A CN 111803244A
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- GUVRBAGPIYLISA-UHFFFAOYSA-N tantalum atom Chemical compound [Ta] GUVRBAGPIYLISA-UHFFFAOYSA-N 0.000 title claims abstract description 78
- 210000000988 bone and bone Anatomy 0.000 title claims abstract description 44
- 238000004519 manufacturing process Methods 0.000 title claims abstract description 20
- 229910052715 tantalum Inorganic materials 0.000 claims abstract description 13
- 239000000126 substance Substances 0.000 claims abstract description 9
- 238000006243 chemical reaction Methods 0.000 claims description 40
- 229910021397 glassy carbon Inorganic materials 0.000 claims description 27
- 238000000034 method Methods 0.000 claims description 20
- 239000000758 substrate Substances 0.000 claims description 17
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims description 11
- 229910004537 TaCl5 Inorganic materials 0.000 claims description 9
- 239000007789 gas Substances 0.000 claims description 9
- 239000000945 filler Substances 0.000 claims description 8
- 239000011148 porous material Substances 0.000 claims description 8
- 210000000629 knee joint Anatomy 0.000 claims description 7
- XKRFYHLGVUSROY-UHFFFAOYSA-N Argon Chemical compound [Ar] XKRFYHLGVUSROY-UHFFFAOYSA-N 0.000 claims description 6
- 238000005229 chemical vapour deposition Methods 0.000 claims description 5
- 229910052786 argon Inorganic materials 0.000 claims description 3
- 210000000544 articulatio talocruralis Anatomy 0.000 claims description 3
- 210000002310 elbow joint Anatomy 0.000 claims description 3
- 210000004394 hip joint Anatomy 0.000 claims description 3
- 239000002994 raw material Substances 0.000 claims description 3
- 210000000323 shoulder joint Anatomy 0.000 claims description 3
- 210000003857 wrist joint Anatomy 0.000 claims description 3
- 239000000463 material Substances 0.000 abstract description 10
- 239000007943 implant Substances 0.000 abstract description 6
- 239000007769 metal material Substances 0.000 abstract description 4
- 230000003628 erosive effect Effects 0.000 abstract description 3
- 230000009286 beneficial effect Effects 0.000 abstract description 2
- 229910001069 Ti alloy Inorganic materials 0.000 description 6
- 238000010146 3D printing Methods 0.000 description 4
- 230000010072 bone remodeling Effects 0.000 description 3
- 239000011159 matrix material Substances 0.000 description 3
- 238000010923 batch production Methods 0.000 description 2
- 230000007547 defect Effects 0.000 description 2
- 238000010586 diagram Methods 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 230000002349 favourable effect Effects 0.000 description 2
- 239000006260 foam Substances 0.000 description 2
- 210000001503 joint Anatomy 0.000 description 2
- 239000012229 microporous material Substances 0.000 description 2
- 230000000399 orthopedic effect Effects 0.000 description 2
- 239000000956 alloy Substances 0.000 description 1
- 230000008468 bone growth Effects 0.000 description 1
- 230000007850 degeneration Effects 0.000 description 1
- 238000000151 deposition Methods 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 230000012010 growth Effects 0.000 description 1
- 238000002513 implantation Methods 0.000 description 1
- 239000012535 impurity Substances 0.000 description 1
- 230000006698 induction Effects 0.000 description 1
- 230000001939 inductive effect Effects 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 239000011664 nicotinic acid Substances 0.000 description 1
- 231100000915 pathological change Toxicity 0.000 description 1
- 230000036285 pathological change Effects 0.000 description 1
- 230000035484 reaction time Effects 0.000 description 1
- 238000009418 renovation Methods 0.000 description 1
- 238000002054 transplantation Methods 0.000 description 1
- 230000008733 trauma Effects 0.000 description 1
- 229910052720 vanadium Inorganic materials 0.000 description 1
- LEONUFNNVUYDNQ-UHFFFAOYSA-N vanadium atom Chemical compound [V] LEONUFNNVUYDNQ-UHFFFAOYSA-N 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/3094—Designing or manufacturing processes
- A61F2/30942—Designing or manufacturing processes for designing or making customized prostheses, e.g. using templates, CT or NMR scans, finite-element analysis or CAD-CAM techniques
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/30767—Special external or bone-contacting surface, e.g. coating for improving bone ingrowth
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/30767—Special external or bone-contacting surface, e.g. coating for improving bone ingrowth
- A61F2/30771—Special external or bone-contacting surface, e.g. coating for improving bone ingrowth applied in original prostheses, e.g. holes or grooves
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/38—Joints for elbows or knees
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/02—Inorganic materials
- A61L27/08—Carbon ; Graphite
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/28—Materials for coating prostheses
- A61L27/30—Inorganic materials
- A61L27/306—Other specific inorganic materials not covered by A61L27/303 - A61L27/32
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/56—Porous materials, e.g. foams or sponges
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/28—Bones
- A61F2002/2835—Bone graft implants for filling a bony defect or an endoprosthesis cavity, e.g. by synthetic material or biological material
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2310/00—Prostheses classified in A61F2/28 or A61F2/30 - A61F2/44 being constructed from or coated with a particular material
- A61F2310/00389—The prosthesis being coated or covered with a particular material
- A61F2310/00395—Coating or prosthesis-covering structure made of metals or of alloys
- A61F2310/00419—Other metals
- A61F2310/00544—Coating made of tantalum or Ta-based alloys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2420/00—Materials or methods for coatings medical devices
- A61L2420/02—Methods for coating medical devices
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2430/00—Materials or treatment for tissue regeneration
- A61L2430/02—Materials or treatment for tissue regeneration for reconstruction of bones; weight-bearing implants
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Transplantation (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Engineering & Computer Science (AREA)
- Heart & Thoracic Surgery (AREA)
- Biomedical Technology (AREA)
- Cardiology (AREA)
- Vascular Medicine (AREA)
- Medicinal Chemistry (AREA)
- Dermatology (AREA)
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- Inorganic Chemistry (AREA)
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Abstract
The application relates to a bone filling block with a tantalum metal porous structure layer, a manufacturing method and application. The beneficial effect of this application does: the highly interconnected honeycomb structure on the surface of the filling block can provide wide bone ingrowth, the high friction coefficient of the material provides good initial stability of the implant, the low elastic modulus can reduce stress shielding, the tantalum metal material has good strength and ductility, the chemical property is stable, chemical erosion can be resisted, the tantalum also has good biocompatibility, and the manufacturing method is simple, convenient and easy.
Description
Technical Field
The application relates to the field of medical orthopedics bionic materials, in particular to a bone filling block with a tantalum metal porous structure layer, a manufacturing method and application.
Background
The trabecular bone knee joint filling block is an implanted prosthesis for knee joint replacement, is mainly suitable for bone defect diseases in knee joint replacement, is used for providing a structural transplantation prosthesis for surgeons, and is suitable for reconstructing knee joint bone defects caused by serious degeneration, trauma or other pathological changes.
At present, most of filling blocks in the related art are 3D printing titanium alloy bone trabecula structures.
In view of the above-mentioned related art, the inventors consider that the following drawbacks exist: the 3D printing technology works by utilizing a high-power laser beam, the power consumption is high, and the manufacturing process is complex; compared with a tantalum metal bone trabecula structure, the titanium alloy bone trabecula structure has poor biocompatibility, and vanadium in the titanium alloy material is separated out in a human body environment and can cause harm to a human body.
Disclosure of Invention
In order to solve the problems that 3D printing power consumption is high, a process is complex, titanium alloy compatibility is poor, elastic modulus is large and harm can be caused to a human body, the application provides a bone filling block with a tantalum metal porous structure layer and a manufacturing method.
In a first aspect, the present application provides a bone filling block with a tantalum metal porous structure layer, which adopts the following technical scheme:
a bone filling block with a tantalum metal porous structure layer comprises a substrate and the tantalum metal porous structure layer on the surface of the substrate.
By adopting the technical scheme, the tantalum metal serving as a new orthopedic implant material in the medical industry has the advantages of better biocompatibility and smaller elastic modulus than titanium alloy, stress shielding can be effectively reduced, higher porosity can be realized, bone growth induction can be facilitated, and the like, so that the tantalum metal is more favorable for bone remodeling and is an ideal bone implant material.
Preferably, the substrate is a reticulated vitreous carbon body, and the pore diameter of the tantalum metal porous structure layer is as follows: 200-800 μm, wire diameter: 100-700 μm, porosity: 50 to 80 percent.
By adopting the technical scheme, the reticular glassy carbon body is a three-dimensional reticular microporous material consisting of glassy foam, has small density, higher chemical stability, specific surface area and large structural strength, is selected with the aperture, the wire diameter and the porosity suitable, tantalum metal is deposited on the reticular glassy carbon body through CVD equipment to form a filling block, the filling blocks at various joint positions are manufactured according to actual requirements, the aperture of 200-; secondly, the weight of the filling block can be reduced, the operation is convenient, the safe and effective operation is facilitated, the success rate of the operation is increased, and the renovation risk is reduced.
In a second aspect, the present application provides a method for manufacturing a bone filling block with a tantalum metal porous structure layer, which adopts the following technical scheme:
a manufacturing method of a bone filling block with a tantalum metal porous structure layer comprises the step of forming the tantalum metal porous structure layer on the surface of a substrate.
By adopting the technical scheme, the tantalum metal porous structure layer is formed on the surface of the substrate to form the filling block, and the growth of bones can be induced by the advantages of the tantalum metal, so that the bone remodeling is facilitated.
Preferably, the substrate is a reticulated vitreous carbon body, and the tantalum metal porous structure layer is formed on the surface of the reticulated vitreous carbon body by a chemical vapor deposition process by using a CVD device.
By adopting the technical scheme, the CVD equipment is chemical vapor deposition equipment, and the tantalum metal can be deposited on the surface of the reticular glassy carbon body under certain process conditions to form the filling block.
Specifically, the method comprises the following steps:
s1, placing raw materials: placing a reticular glassy carbon matrix into a second reaction chamber of a vacuum high-temperature reaction furnace, and placing pure tantalum into a first reaction chamber of the vacuum high-temperature reaction furnace;
s2, removing air in the first reaction chamber and the second reaction chamber, and then introducing argon into the first reaction chamber and the second reaction chamber for protection;
s3, introducing Cl into the first reaction chamber and the second reaction chamber2And H2，Cl2Reacting with pure tantalum to produce TaCl5Gas, TaCl5And the gas enters a second reaction chamber to react with H2 for a period of time at a certain temperature, and a tantalum simple substance is replaced on the reticular glassy carbon matrix to form a tantalum metal porous structure layer, so that the manufacturing of the tantalum metal bone trabecula filling block is completed.
By adopting the technical scheme, the whole process flow is simpler, the process conditions are relatively easy to control, a plurality of reticular glassy carbon matrixes can be placed in the second reaction chamber at the same time, a plurality of filling blocks are processed at one time, and the batch production is facilitated.
Preferably, in the step S3, TaCl is added5Gas enters the second reaction chamber and H2The reaction was carried out at a temperature of 900 ℃ and 1100 ℃ for 5 to 7 hours.
By adopting the technical scheme, the process conditions of the reaction temperature and the reaction time are easy to control, and the 3D printing mode is simpler.
In a third aspect, the present application provides a knee joint, hip joint, shoulder joint, elbow joint, wrist joint, ankle joint or spinal product using a bone filler block having a tantalum metal porous structural layer as described in any one of the above.
In summary, the present application includes at least one of the following beneficial technical effects:
1. the honeycomb structure with highly interconnected surfaces can provide wide bone ingrowth, the high friction coefficient of the material provides good initial stability of the implant, the low elastic modulus can reduce stress shielding, the tantalum metal material has good strength and ductility, can resist chemical erosion, and the tantalum also has good biocompatibility; the strength and the elastic modulus of the porous tantalum are close to those of normal human cancellous bone with equivalent porosity, so that the stress shielding effect of the material is reduced, and the material is better matched with the bone, so that the initial stability of the artificial bone implant is improved;
2. the manufacturing method provided by the application has the advantages of simple process flow and easily controlled process conditions, and is suitable for batch production.
Drawings
Fig. 1 is a schematic view of a filament structure of a reticular vitreous carbon body and a tantalum metal porous structure layer according to an embodiment of the present disclosure.
Fig. 2 is a schematic flow structure diagram according to a first embodiment of the present application.
Fig. 3 is a block diagram of the present application in use with a trabecular bone.
Description of reference numerals: 1. a substrate; 2. a tantalum metal porous structure layer; 3. a first reaction chamber; 4. a tantalum metal block; 5. a second reaction chamber.
Detailed Description
The present application is described in further detail below with reference to figures 1-2.
Example one
The embodiment of the application discloses a bone filling block with a tantalum metal porous structure layer, and the bone filling block with the tantalum metal porous structure layer refers to fig. 1 and comprises a substrate 1 and a tantalum metal porous structure layer 2 on the surface of the substrate 1. The tantalum metal has the advantages of better biocompatibility, smaller elastic modulus, more effective reduction of stress shielding, higher porosity, more contribution to inducing bone ingrowth and the like compared with titanium alloy, thereby being more favorable for bone remodeling and being an ideal bone implantation material.
In this embodiment, the substrate 1 is a reticulated vitreous carbon body, and the pore diameter of the tantalum metal porous structure layer 2 is as follows: 200-800 μm, wire diameter: 100-700 μm, porosity: 50 to 80 percent.
The reticular glassy carbon body is a three-dimensional reticular microporous material consisting of glassy foam, has small density, higher chemical stability, specific surface area and large structural strength, is selected with the aperture, the wire diameter and the porosity suitable, tantalum metal is deposited on the reticular glassy carbon body through CVD equipment to form a filling block, the filling block at various joint positions is manufactured according to actual requirements, the aperture of 200-.
The implementation principle of the bone filling block with the tantalum metal porous structure layer 2 in the embodiment of the application is as follows: the tantalum metal is deposited on the surface of the reticular vitreous carbon body through a CVD device to form the filling blocks, and different filling blocks are manufactured according to different shapes of the reticular vitreous carbon body and are used for filling different joints.
In the present embodiment, the pore diameter of the reticulated vitreous carbon body: 400 μm, filament diameter: 300 μm, porosity: 70%, after the processing of step S3, the pore diameter of the whole after the tantalum metal porous structure layer 2 is formed: 500 μm, filament diameter: 400 μm, porosity: 80 percent.
The embodiment of the application also discloses a manufacturing method of the bone filling block with the tantalum metal porous structure layer. Referring to fig. 2, the method includes the step of forming a tantalum metal porous structure layer 2 on the surface of a substrate 1.
Specifically, the substrate 1 is a reticulated vitreous carbon body, and the tantalum metal porous structure layer 2 is formed on the surface of the reticulated vitreous carbon body by a chemical vapor deposition process by using a CVD apparatus.
More specifically, the method comprises the following steps:
s1, placing raw materials: placing the reticular glassy carbon matrix 1 into a second reaction chamber 5 of a vacuum high-temperature reaction furnace, and placing pure tantalum into a first reaction chamber 3 of the vacuum high-temperature reaction furnace;
s2, wherein TaCl5Will react with water in the air to generate TaOCl3Impurities, so that air in the first reaction chamber 3 and the second reaction chamber 5 needs to be removed firstly, and then argon is introduced for protection;
s3, introducing Cl into the first reaction chamber 3 and the second reaction chamber 52And H2，Cl2Reacting with pure tantalum to produce TaCl5Gas, TaCl5Gas enters the second reaction chamber 5 and H2Reacting for a period of time at a certain temperature, replacing a tantalum simple substance on the reticular glassy carbon substrate 1 to form a tantalum metal porous structure layer 2, and finishing the manufacturing of the tantalum metal bone trabecula filling block.
In the present embodiment, in step S3, TaCl5Gas enters the second reaction chamber 5 and H2And reacting at 1100 ℃ for 6 hours to form the tantalum metal mechanism layer.
The implementation principle of the manufacturing method of the bone filling block with the tantalum metal porous structure layer 2 in the embodiment of the application is as follows: depositing tantalum metal on the surface of the reticular glassy carbon body by using CVD equipment and a chemical vapor deposition process to form a tantalum metal porous structure layer 2, wherein the specific reaction process is as follows:
2Ta+5Cl2→2TaCl5；
2TaCl5+5H2=2Ta+10HCl；
pore size of the tantalum metal structure formed: 500 +/-100 mu m, the diameter of the porous structure of the trabecular bone: 400 ± 100 μm, porosity: 50% -80%; the highly interconnected honeycomb structure of the porous structure on the surface of the tantalum metal material can provide wide bone ingrowth, the high friction coefficient of the material provides good initial stability of the implant, the low elastic modulus can reduce stress shielding, the tantalum metal material has good strength and ductility and can resist chemical erosion, and the tantalum material also has good biocompatibility.
The bone filling block with the tantalum metal porous structure layer can be applied to any one of knee joints, hip joints, shoulder joints, elbow joints, wrist joints, ankle joints and spine products.
Referring to fig. 3, the filling block can be used in conjunction with trabecular bone, but can also be used in conjunction with other joints.
The above embodiments are preferred embodiments of the present application, and the protection scope of the present application is not limited by the above embodiments, so: all equivalent changes made according to the structure, shape and principle of the present application shall be covered by the protection scope of the present application.
Claims (8)
1. A bone filler block with a tantalum metal porous structure layer is characterized in that: comprises a substrate (1) and a tantalum metal porous structure layer (2) on the surface of the substrate (1).
2. The bone filler block with a tantalum metal porous structure layer as claimed in claim 1, wherein: the substrate (1) is a reticular glassy carbon body, and the pore diameter of the tantalum metal porous structure layer (2) is as follows: 200-800 μm, wire diameter: 100-700 μm, porosity: 50 to 80 percent.
3. A manufacturing method of a bone filling block with a tantalum metal porous structure layer is characterized in that: comprises the step of forming a tantalum metal porous structure layer (2) on the surface of a substrate (1).
4. The method for manufacturing a bone filler block with a tantalum metal porous structure layer as claimed in claim 3, wherein: the base body (1) is a reticular glassy carbon body, and the tantalum metal porous structure layer (2) is formed on the surface of the reticular glassy carbon body by a chemical vapor deposition process by adopting CVD equipment.
5. The method for manufacturing a bone filler block with a tantalum metal porous structure layer as claimed in claim 4, wherein: the method comprises the following steps:
s1, placing raw materials: placing a reticular glassy carbon body into a second reaction chamber (5) of a vacuum high-temperature reaction furnace, and placing pure tantalum into a first reaction chamber (3) of the vacuum high-temperature reaction furnace;
s2, removing air in the first reaction chamber (3) and the second reaction chamber (5), and introducing argon into the first reaction chamber (3) and the second reaction chamber (5) for protection;
s3, introducing Cl into the first reaction chamber (3) and the second reaction chamber (5)2And H2，Cl2Reacting with pure tantalum to produce TaCl5Gas, TaCl5Gas enters the second reaction chamber (5) and H2Reacting for a period of time at a certain temperature, replacing a tantalum simple substance on the reticular glassy carbon body to form a tantalum metal porous structure layer, and finishing the manufacturing of the tantalum metal bone trabecula filling block.
6. The method for manufacturing a bone filler block with a tantalum metal porous structure layer as claimed in claim 5, wherein: in the step S3, TaCl5The gas enters the second reaction chamber (5) and reacts with H2 at the temperature of 900-1100 ℃ for 5-7 hours.
7. The method for manufacturing a bone filler block with a tantalum metal porous structure layer as claimed in claim 4, wherein: pore diameter of the reticulated vitreous carbon body: 100-1000 μm, filament diameter: 200-600 μm, porosity: 60% -90%, after the treatment of step S3, the pore diameter of the whole after the tantalum metal porous structure layer (2) is formed is as follows: 200-800 μm, wire diameter: 100-700 μm, porosity: 50 to 80 percent.
8. A knee joint, a hip joint, a shoulder joint, an elbow joint, a wrist joint, an ankle joint or a spine using the bone filler block having the tantalum metal porous structure layer according to any one of claims 1 to 2.
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| CN117399774A (en) * | 2023-12-12 | 2024-01-16 | 北京市春立正达医疗器械股份有限公司 | CVD hip joint vacuum diffusion welding prosthesis manufacturing method and hip joint prosthesis |
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