CN111789766A - Seed source forming device - Google Patents

Seed source forming device Download PDF

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Publication number
CN111789766A
CN111789766A CN202010816516.9A CN202010816516A CN111789766A CN 111789766 A CN111789766 A CN 111789766A CN 202010816516 A CN202010816516 A CN 202010816516A CN 111789766 A CN111789766 A CN 111789766A
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China
Prior art keywords
vibration
unit
seat
forming
seed source
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Pending
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CN202010816516.9A
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Chinese (zh)
Inventor
邵国强
王自正
王峰
王书奎
俞杨
倪玉丹
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Nanjing First Hospital
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Nanjing First Hospital
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Priority to CN202010816516.9A priority Critical patent/CN111789766A/en
Publication of CN111789766A publication Critical patent/CN111789766A/en
Pending legal-status Critical Current

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61JCONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J3/00Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
    • GPHYSICS
    • G21NUCLEAR PHYSICS; NUCLEAR ENGINEERING
    • G21GCONVERSION OF CHEMICAL ELEMENTS; RADIOACTIVE SOURCES
    • G21G4/00Radioactive sources
    • G21G4/04Radioactive sources other than neutron sources
    • G21G4/06Radioactive sources other than neutron sources characterised by constructional features
    • G21G4/08Radioactive sources other than neutron sources characterised by constructional features specially adapted for medical application

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • General Engineering & Computer Science (AREA)
  • High Energy & Nuclear Physics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Physics & Mathematics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Crystals, And After-Treatments Of Crystals (AREA)

Abstract

The invention discloses a seed source forming device, belonging to the technical field of medicament preparation; the invention comprises a vibration unit, a seed source forming unit and an extrusion unit; the seed source forming unit comprises a powder bin, a forming seat and a lower thimble, and a powder discharging hole is formed in the bottom of the powder bin; the forming seat is arranged below the powder bin and provided with a forming cavity which penetrates up and down, and the forming cavity, the powder feeding hole and the lower thimble are correspondingly arranged; the extrusion unit comprises an upper thimble which is arranged above the powder bin in a manner of moving up and down, and the upper thimble is arranged corresponding to the medicine discharging hole; the vibration unit is connected with the forming seat and used for driving the forming seat to vibrate along the vertical direction; according to the invention, the vibration unit drives the forming seat to vibrate in the vertical direction, so that the seed source raw material in the powder bin can automatically enter the forming cavity, the blanking uniformity in each preparation process can be ensured, and the seed source specification standardization is obtained.

Description

Seed source forming device
Technical Field
The invention relates to the technical field of medicament preparation, and relates to a seed source forming device.
Background
The 20 th century began with the treatment of brachytherapy between tissues, which mainly involved intraluminal or intratubular irradiation, interstitial irradiation, irradiation of intraoperative catheters, and the like. Particularly, with the development of image-mediated implantation technologies such as ultrasound, CT, MRI, endoscope and the like and the optimization of a computer three-dimensional treatment planning system, the radiotherapy implantation operation and positioning are more accurate, the dose distribution is more uniform and reasonable, and the implantation of brachytherapy tumors among tissues shows stronger vitality. The radiotherapy with the metal seed source implanted between tissues, such as 125I, 103Pd and the like, is one type of brachytherapy, has good curative effect, small damage to normal tissues, uniform tissue dose distribution at a target area and safety for medical care personnel, and obtains good curative effect after multiple hospitals at home and abroad carry out the work successively, particularly to untreated primary tumors; secondly, tissues with the need of keeping the functionality or operations will affect the tumor of the important organs; cases in which radical surgery cannot be performed; preventing local and regional tumor diffusion; metastatic tumor focus or isolated tumor metastasis after operation and loss of operation value; sixthly, the patient is lost after external irradiation; seventhly, external irradiation is unsatisfactory and is used as local irradiation dose supplement; the residual tumor or incisal margin in the operation is too close to the tumor (less than or equal to 0.15 cm). Has wide clinical application prospect.
Is commonly used at present125I、103The seed sources such as Pd are mostly coated by titanium alloy, and the titanium alloy is locally applied in the tumor implantation, so that the titanium alloy is ineffective to a metastatic focus, permanently stays after the titanium alloy acts in a body, is difficult to be applied again by a relapser and has many complications caused by ectopic migration and the like. The biodegradable high molecular material is used as a medicine (radioactivity and/or chemical) carrier, can be ground by a ball mill to prepare nano powder, can be uniformly mixed with a loaded medicine under the action of a dispersing agent, and can be heated, dried and ground into powder again, and the shape plasticity is strong after high-pressure extrusion, so that the biodegradable high molecular material is an important reason for preparing the seed source by compression molding.
The manual pressing machine is a main device for preparing the loaded radiopharmaceutical seed source at the early stage, and the main principle is as follows: use the metal sheet as the mould, middle trompil, the hole is the cylinder type hole of seed source diameter, will take the hard gasket of lower needle to seal the lower extreme in seed source mould hole, and the toper feed bin is connected to the mould upper end, vibrates through whole manual rotation and fills the mould with powder from the feed bin, removes the feed bin, puts into particle suppression frame with particle mould and hard gasket, with mould hole and suppression target to accurate direction, filler in the rotatory suppression handle extrusion mould hole, preparation seed source.
The seed source has uniform texture and uniform hardness, but the feeding amount and the pressing pressure of the powder of the manual pressing machine are totally dependent on experience, the quantification and the normalization are difficult, the defects of needle breakage, inconsistent seed source size, low manual operation efficiency and the like frequently occur in the operation, particularly, the defects that an operator needs to be directly exposed, the powder is inhaled and directly exposed in the operation process, and the like directly influence the specific implementation of the manual pressing machine.
However, the prior blanking process has a problem that the seed source is small, the cavity for producing the die is also small, the medicinal powder of the seed source raw material is difficult to fill in the cavity as much as possible under the bridging effect and the electrostatic action, namely, the medicinal powder entering the cavity has different quantities, so that the seed source prepared each time is different in size, and the phenomenon can be caused no matter manual compaction or machine compaction at the moment.
Patent publication No. CN 102436860A discloses a medical radioactive seed source automatic production equipment, mentions among this equipment that to use the source core in the automatic production equipment to divide material, single unloading and vibration dish control, gets an output O signal on the IO integrated circuit board, control relay, with vibration dish power signal connection in relay normal open port, signal output O is relay action actuation in the low level, vibration dish power supply begins the vibration, single unloading of source core. Although this vibration mode promotes the falling of the powder, there is still a problem of uneven filling of the powder in the formed cavity.
Disclosure of Invention
The invention aims to provide a seed source forming device aiming at the problems of automation and low homogenization degree of seed source preparation in the prior art, the device realizes automatic filling of raw materials in a forming cavity by vibration of a powder bin containing the raw materials for preparing the seed source and the forming cavity in the vertical direction, and the filling rate is uniform.
In order to achieve the purpose, the technical scheme provided by the invention is as follows:
the invention discloses a seed source forming device, which comprises a vibration unit, a seed source forming unit and an extrusion unit; the seed source forming unit comprises a powder bin, a forming seat and a lower thimble, and a powder discharging hole is formed in the bottom of the powder bin; the forming seat is arranged below the powder bin and provided with a forming cavity which penetrates up and down, and the forming cavity is arranged corresponding to the powder discharge hole; the lower thimble is arranged below the molding cavity in a manner of moving up and down, and the lower thimble is arranged corresponding to the molding cavity; the extrusion unit comprises an upper thimble which is arranged above the powder bin in a manner of moving up and down, and the upper thimble is arranged corresponding to the medicine discharging hole; the vibration unit is connected with the forming seat and used for driving the forming seat to vibrate along the vertical direction. The vibration unit drives the forming seat to vibrate in the vertical direction, so that the seed source raw materials in the powder bin can automatically enter the forming cavity, and personnel radiation caused by direct exposure of operators to radioactive powder is avoided; bridging effect and electrostatic effect can be overcome, the blanking uniformity in each preparation process is ensured, and the seed source specification standardization is obtained; the operation safety of the equipment is ensured, the automatic operation is realized, the failure rate is reduced, and the production efficiency is improved; the service life of the instrument is prolonged, and related maintenance cost and raw material waste are reduced. Meanwhile, through setting the batch task quantity, the tedious manual counting and the occurrence of idle operation conditions can be avoided.
Preferably, the vibration unit comprises a shaft seat, a vibration piece, a vibration wheel and a vibration motor, wherein one end of the vibration piece is coupled to the shaft seat, and the other end of the vibration piece is connected with the forming seat and can vibrate along the vertical direction; the lateral part of vibration piece is provided with the vibration wheel, the vibration wheel is driven by vibrating motor, and the eccentric part of vibration wheel passes through flexible vibration connecting piece and links to each other with the vibration piece, and the vibration wheel rotates and is provided with the one end up-and-down motion of shaping seat by flexible vibration connecting piece drive vibration piece.
Preferably, the extrusion unit further comprises an upper needle driving motor, an upper needle driving telescopic rod and an upper ejector rod, the upper needle driving telescopic rod is arranged on the upper needle driving motor and driven by the upper needle driving motor, the upper ejector rod is arranged at one end, far away from the upper needle driving motor, of the upper needle driving telescopic rod, and the other end of the upper ejector rod is connected with an upper ejector pin.
Preferably, the seed source forming unit further comprises a lower needle base, a lower needle driving motor and a lower ejector rod, the lower needle base is arranged at the bottom of the forming base, a lower needle hole is formed in the lower needle base, the lower needle driving motor is used for driving the lower ejector rod to move up and down, a lower ejector pin is connected to the upper end of the lower ejector rod, and the lower ejector pin is correspondingly arranged in the lower needle hole.
Preferably, the vibration device further comprises a limiting unit, wherein the limiting unit comprises an upper limiting block and/or a lower limiting seat, and the upper limiting block is fixedly arranged above the vibration piece and used for limiting the upward movement amplitude of the vibration piece; and/or the lower limiting seat is arranged below the vibrating piece and used for limiting the downward movement amplitude of the vibrating piece.
Preferably, the seed source collecting unit comprises a collecting pipe and a collecting bottle, the collecting pipe is connected into the collecting bottle, and one end of the collecting pipe outside the collecting bottle can be correspondingly arranged below the forming cavity.
Preferably, the extrusion unit further comprises an upper needle base, the upper needle driving telescopic rod is connected with the upper ejector rod through the upper needle base, a positioning rod is arranged on the upper needle base, and the positioning rod below the upper needle base is arranged in a positioning hole of the forming base; the positioning rod is used for fixing the relative position of the upper ejector rod and the forming seat in the horizontal direction.
Preferably, the limiting unit further comprises a limiting driving cylinder and a limiting telescopic rod, the limiting driving cylinder drives the limiting telescopic rod to move up and down, and one end, far away from the limiting driving cylinder, of the limiting telescopic rod is connected with an upper limiting block.
Preferably, the seed source collecting unit further comprises a collecting motor and a driving rod, the collecting motor drives the driving rod to move, and the driving rod is used for driving one end of the collecting pipe outside the collecting bottle to move.
Preferably, the device also comprises a rack, wherein the rack comprises a base and a supporting piece, the supporting piece is vertically arranged on the base, and a supporting plate is arranged at the top end of the supporting piece; the shaft seat of the vibration unit is arranged on the base, and the vibration wheel and the vibration motor are supported by the support piece; or the supporting plate is provided with a first through hole which is used for supporting and fixing the limiting unit; or the supporting plate is provided with a second through hole which is used for supporting and fixing the extrusion unit; or the lower needle driving motor of the seed source forming unit is arranged on the base.
Drawings
FIG. 1 is a schematic view of an overall structure of a seed source forming apparatus according to the present invention;
FIG. 2 is a schematic structural diagram of a frame of a seed source forming apparatus according to the present invention;
FIG. 3 is a cross-sectional view of a visible vibration unit of a seed source forming apparatus of the present invention;
FIG. 4 is a side view of a visible vibratory wheel attachment for a seed forming apparatus of the present invention;
FIG. 5 is a schematic view of an overall structure of a seed source forming apparatus according to the present invention, including a cross-sectional view;
FIG. 6 is a schematic diagram of a partial enlarged structure of a seed source forming unit of the seed source forming device according to the present invention;
FIG. 7 is a schematic diagram of the movement of a seed source forming unit during the preparation process of the seed source forming device according to the present invention;
FIG. 8 is a side view of a seed collecting unit of the seed forming apparatus of the present invention;
FIG. 9 is a top view of a seed formation apparatus of the present invention.
The reference numerals in the schematic drawings illustrate:
100. a frame; 110. a base; 120. a support member; 121. a support plate; 131. a first perforation; 132. a second perforation; 140. a cushion pad;
200. a vibration unit; 210. a shaft seat; 211. a rotating shaft; 220. a vibrating member; 221. a support spring; 230. a vibrating wheel; 231. a vibration motor; 232. a flexible vibration link; 240. a connecting seat;
300. a seed source forming unit; 320. a powder bin; 321. a molding cavity; 330. forming a base; 340. a lower needle seat; 341. a lower needle driving motor; 342. a lower ejector rod; 343. a lower thimble;
400. a pressing unit; 410. an upper needle driving motor; 420. the upper needle drives the telescopic rod; 430. an ejector rod is arranged; 431. an upper thimble; 432. an upper needle mount; 440. an upper needle base; 441. positioning a rod;
500. a limiting unit; 510. a limiting driving cylinder; 520. limiting the telescopic rod; 521. an upper limit block; 530. a lower limit seat;
600. a seed source collecting unit; 610. a collection pipe; 620. a collection bottle; 630. collecting the motor; 631. a drive rod.
Detailed Description
For a further understanding of the invention, reference should be made to the following detailed description taken in conjunction with the accompanying drawings and examples.
The structure, proportion, size and the like shown in the drawings are only used for matching with the content disclosed in the specification, so that the person skilled in the art can understand and read the description, and the description is not used for limiting the limit condition of the implementation of the invention, so the method has no technical essence, and any structural modification, proportion relation change or size adjustment still falls within the scope covered by the technical content disclosed by the invention without affecting the effect and the achievable purpose of the invention. Meanwhile, the terms such as "upper", "lower", "left", "right" and "middle" used in the present specification are for clarity of description only, and are not used to limit the implementable scope, and the relative relationship changes or adjustments may be considered to be within the implementable scope of the present invention without substantial technical changes; in addition, the embodiments of the present invention are not independent of each other, but may be combined.
Example 1
As shown in fig. 1, a seed source molding apparatus of the present embodiment includes a frame 100, a vibration unit 200, a seed source molding unit 300, an extrusion unit 400, a limiting unit 500, and a seed source collecting unit 600; the main function of the frame 100 is to support the whole device; the vibration unit 200 is used for providing a vibration power source, and the seed source molding unit 300 is used for molding the medicinal powder to prepare a seed source; the pressing unit 400 is used for providing pressure for powder molding, and the limiting unit 500 is used for limiting the amplitude of the vibration unit 200; the seed source collecting unit 600 is used for collecting prepared seed sources, and the specific structure and the working principle of the device are as follows.
As shown in fig. 2, the rack 100 includes a base 110 and a support 120, the support 120 is vertically disposed on the base 110, and a support plate 121 is disposed at a top end of the support 120; as shown in fig. 5 to 7, the seed source molding unit 300 includes a powder bin 320, a molding base 330 and a lower thimble 343, wherein a powder discharge hole is formed at the bottom of the powder bin 320; the forming base 330 is arranged below the powder bin 320, the forming base 330 is provided with a forming cavity 321 which penetrates up and down, and the forming cavity 321 is arranged corresponding to the medicine feeding hole; the lower ejector pins 343 are disposed below the molding cavities 321 so as to be movable up and down, and the lower ejector pins 343 are disposed corresponding to the molding cavities 321; the pressing unit 400 includes an upper thimble 431, the upper thimble 431 is disposed above the powder bin 320 to be movable up and down, and the upper thimble 431 is disposed corresponding to the lower medicine hole.
The raw material for preparing the seed source is stored in the powder bin 320 in advance, and in the preparation process, the raw material falls into the molding cavity 321 from the powder bin 320, the lower thimble 343 moves to the lower part of the molding cavity 321 to block the molding cavity, the upper thimble 431 falls into the powder bin 320, and the raw material in the molding cavity 321 is extruded and molded from the upper part of the molding cavity 321. Specifically, in the extrusion process, the upper thimble 431 firstly passes through the powder bin 320 at a speed of 1-3cm/s and then reaches a position 0.2-0.5cm above the molding cavity 321, and the upper thimble 431 then enters the molding cavity 321 at a speed of 0.05-0.2cm/s to extrude the raw materials in the molding cavity 321.
More specifically, in this embodiment, the supporting plate 121 is provided with a second through hole 132, the second through hole 132 is used for supporting and fixing the extruding unit 400, the extruding unit 400 further includes an upper needle driving motor 410, an upper needle driving telescopic rod 420 and an upper ejector rod 430, the upper needle driving telescopic rod 420 is arranged on the upper needle driving motor 410 and driven by the upper needle driving motor 410, the upper ejector rod 430 is arranged at one end of the upper needle driving telescopic rod 420 far away from the upper needle driving motor 410, and the other end of the upper ejector rod 430 is connected with an upper ejector pin 431.
In order to accurately enter the molding cavity 321 in the dropping process of the upper thimble 431, on one hand, the bottom of the powder bin 320 is funnel-shaped, so that the dropping process of the upper thimble 431 is easily positioned in the molding cavity 321, on the other hand, the extrusion unit 400 further comprises an upper needle seat 440, the upper needle driving telescopic rod 420 and the upper thimble 430 are connected through the upper needle seat 440, a positioning rod 441 is arranged on the upper needle seat 440, and the positioning rod 441 below the upper needle seat 440 is arranged in a positioning hole of the molding seat 330; the positioning rod 441 is used for fixing the relative position of the upper mandril 430 and the forming base 330 in the horizontal direction; by the guiding action of the positioning rod 441, the upper ejector pin 431 carried by the upper ejector rod 430 cannot laterally shift in the moving process, so that the upper ejector pin 431 cannot enter the molding cavity 321, and the arrangement is also beneficial to the vibration process described later.
It should be noted that, the upper needle hub 440 and the upper ejector rod 430 are connected by a snap-fit connection of the upper needle mounting member 432 including a snap groove, so that the upper needle hub 440 provided with the upper ejector needle 431 is convenient to detach from or connect to the upper ejector rod 430.
The above is the basic seed source forming process, but the problem exists at present is that the raw material in the forming cavity 321 falls and cannot be fully filled, so that the seed source prepared in each preparation process is different in size.
The vibration unit 200 is connected to the forming base 330, and is configured to drive the forming base 330 to vibrate in the vertical direction, and the forming base 330 vibrates in the vertical direction, so that the raw material entering the forming cavity 321 can overcome the bridging effect and the electrostatic force, and thus the forming cavity 321 is fully filled, and the homogenization of the seed source preparation is achieved each time.
More specifically, in this embodiment, as shown in fig. 2 to 3, the vibration unit 200 includes a shaft seat 210, a vibration member 220, a vibration wheel 230, and a vibration motor 231, the shaft seat 210 of the vibration unit 200 is disposed on the base 110, and the vibration wheel 230 and the vibration motor 231 are supported by the support member 120; one end of the vibrating member 220 is coupled to the shaft seat 210 through the rotating shaft 211, and the other end of the vibrating member 220 is coupled to the forming seat 330 and can vibrate in the up-and-down direction; the side of the vibrating element 220 is provided with a vibrating wheel 230, the vibrating wheel 230 is driven by a vibrating motor 231, the eccentric part of the vibrating wheel 230 is connected with the vibrating element 220 through a flexible vibrating connecting piece 232, when the vibrating wheel 230 rotates, the flexible vibrating connecting piece 232 drives the vibrating element 220 to vibrate due to the connection of the flexible vibrating connecting piece 232 on the eccentric part, and in addition, the vibrating element 220 can only vibrate in the up-and-down direction due to the motion limiting effect of the rotating shaft 211 on the shaft seat 210; the rotation of the vibration wheel 230 is realized, and the flexible vibration connecting part 232 drives one end of the vibration part 220, which is provided with the forming seat 330, to move up and down.
In this embodiment, the vibration member 220 is a vibration plate, the flexible vibration connecting member 232 is a spring, and the vibration wheel 230 is more stably connected to the vibration plate through the connecting seat 240 provided on the vibration plate.
In order to limit the vibration amplitude, the present embodiment further includes a limiting unit 500, where the limiting unit 500 includes an upper limiting block 521 and/or a lower limiting seat 530, the upper limiting block 521 is fixedly disposed above the vibrating element 220 for limiting the upward movement amplitude of the vibrating element 220; and/or the lower stopper 530 is disposed below the vibration member 220 for limiting the downward movement of the vibration member 220; specifically, the supporting plate 121 is provided with a first through hole 131, the first through hole 131 is used for supporting and fixing the limiting unit 500, the limiting unit 500 further comprises a limiting driving cylinder 510 and a limiting telescopic rod 520, the limiting driving cylinder 510 drives the limiting telescopic rod 520 to move up and down, one end of the limiting telescopic rod 520 far away from the limiting driving cylinder 510 is connected with an upper limiting block 521, and the height of the upper limiting block 521 can be controlled by the limiting driving cylinder 510 so as to control the vibration amplitude of the vibrating piece 220.
In addition, the seed source molding unit 300 further comprises a lower needle seat 340, a lower needle driving motor 341 and a lower ejector rod 342, the lower needle seat 340 is arranged at the bottom of the molding seat 330, a lower needle hole is arranged on the lower needle seat 340, the lower needle driving motor 341 is used for driving the lower ejector rod 342 to move up and down, the lower ejector needle 343 is connected to the upper end of the lower ejector rod 342, the lower ejector needle 343 is correspondingly arranged in the lower needle hole, and in the using process, if the lower ejector needle 343 is required to block the bottom of the molding cavity 321, the lower needle driving motor 341 drives the molding cavity to ascend; when the seed source is prepared and needs to be fed, as shown in fig. 7, the lower needle driving motor 341 drives the seed source to descend, and at the moment, the upper needle driving motor 410 drives the upper thimble 431 to descend, so that the finished seed source can be ejected.
In this embodiment, as shown in fig. 8 to 9, the seed source collecting unit 600 further includes a collecting pipe 610 and a collecting bottle 620, the collecting pipe 610 is connected to the inside of the collecting bottle 620, one end of the collecting pipe 610 outside the collecting bottle 620 is correspondingly disposed below the forming cavity 321, specifically, the seed source collecting unit 600 further includes a collecting motor 630 and a driving rod 631, the collecting motor 630 drives the driving rod 631 to move, and the driving rod 631 is used for driving one end of the collecting pipe 610 outside the collecting bottle 620 to move; before the upper needle driving motor 410 drives the upper needle 431 to descend to eject the seed product, the current collector 630 drives the driving rod 631 to move, and drives one end of the collecting pipe 610 outside the collecting bottle 620 to move to a position correspondingly below the molding cavity 321, so that the seed product is collected.
In the embodiment, the vibration amplitude of the seed source forming unit 300 in the vertical direction is 1-2cm, the problem of uneven blanking caused by static electricity and other factors can be effectively solved in the amplitude range, and qualified seed sources with uniform texture and size are obtained; the height of the prepared cylindrical seed source is 1.5-4 mm, the specifications are 1.5mm, 2.0mm, 2.5mm and 4mm, the diameter is 1.0-1.5mm, the hardness is 4-5N, and the texture is uniform.
In addition, in this embodiment, the seed source forming device further includes a sealing cover, and the sealing cover seals and isolates the rack 100, the vibrating unit 200, the seed source forming unit 300, the extruding unit 400, the limiting unit 500, and the seed source collecting unit 600 from the outside to prevent the radioactive dust from leaking to pollute the environment and individuals.
The invention has been described in detail hereinabove with reference to specific exemplary embodiments thereof. It will, however, be understood that various modifications and changes may be made without departing from the scope of the invention as defined in the appended claims. The detailed description and drawings are to be regarded as illustrative rather than restrictive, and any such modifications and variations are intended to be included within the scope of the present invention as described herein. Furthermore, the background is intended to be illustrative of the state of the art as developed and the meaning of the present technology and is not intended to limit the scope of the invention or the application and field of application of the invention.
More specifically, although exemplary embodiments of the invention have been described herein, the invention is not limited to these embodiments, but includes any and all embodiments modified, omitted, combined, e.g., between various embodiments, adapted and/or substituted, as would be recognized by those skilled in the art from the foregoing detailed description. The limitations in the claims are to be interpreted broadly based the language employed in the claims and not limited to examples described in the foregoing detailed description or during the prosecution of the application, which examples are to be construed as non-exclusive. Any steps recited in any method or process claims may be executed in any order and are not limited to the order presented in the claims. The scope of the invention should, therefore, be determined only by the appended claims and their legal equivalents, rather than by the descriptions and examples given above.

Claims (10)

1. A seed source forming device is characterized by comprising a vibration unit (200), a seed source forming unit (300) and an extrusion unit (400);
the seed source molding unit (300) comprises a medicine powder bin (320), a molding base (330) and a lower ejector pin (343), wherein a medicine discharging hole is formed in the bottom of the medicine powder bin (320); the forming seat (330) is arranged below the powder bin (320), the forming seat (330) is provided with a forming cavity (321) which penetrates up and down, and the forming cavity (321) is arranged corresponding to the powder discharge hole; the lower ejector pin (343) is arranged below the molding cavity (321) in a manner of moving up and down, and the lower ejector pin (343) is arranged corresponding to the molding cavity (321);
the extrusion unit (400) comprises an upper thimble (431), the upper thimble (431) is arranged above the powder bin (320) in a manner of moving up and down, and the upper thimble (431) is arranged corresponding to the medicine discharging hole;
the vibration unit (200) is connected with the forming base (330) and used for driving the forming base (330) to vibrate along the vertical direction.
2. A seed source forming device according to claim 1, wherein the vibration unit (200) comprises a shaft seat (210), a vibration member (220), a vibration wheel (230) and a vibration motor (231), one end of the vibration member (220) is coupled to the shaft seat (210), and the other end of the vibration member (220) is connected to the forming seat (330) and can vibrate in the up-and-down direction; the lateral part of vibration piece (220) is provided with vibration wheel (230), vibration wheel (230) are driven by vibrating motor (231), and the eccentric part of vibration wheel (230) passes through flexible vibration connecting piece (232) and links to each other with vibration piece (220), and vibration wheel (230) rotate and are driven the one end up-and-down motion that vibration piece (220) were provided with shaping seat (330) by flexible vibration connecting piece (232).
3. The seed source molding device according to claim 1, wherein the extrusion unit (400) further comprises an upper needle driving motor (410), an upper needle driving telescopic rod (420) and an upper ejector rod (430), the upper needle driving telescopic rod (420) is arranged on the upper needle driving motor (410) and driven by the upper needle driving motor (410), the upper ejector rod (430) is arranged at one end of the upper needle driving telescopic rod (420) far away from the upper needle driving motor (410), and the other end of the upper ejector rod (430) is connected with an upper ejector pin (431).
4. The seed source molding device according to claim 1, wherein the seed source molding unit (300) further comprises a lower needle seat (340), a lower needle driving motor (341) and a lower ejector pin (342), the lower needle seat (340) is disposed at the bottom of the molding seat (330), a lower needle hole is disposed on the lower needle seat (340), the lower needle driving motor (341) is used for driving the lower ejector pin (342) to move up and down, the lower ejector pin (343) is connected to the upper end of the lower ejector pin (342), and the lower ejector pin (343) is correspondingly disposed in the lower needle hole.
5. A seed source forming device according to claim 1, further comprising a limiting unit (500), wherein the limiting unit (500) comprises an upper limiting block (521) and/or a lower limiting seat (530), the upper limiting block (521) is fixedly arranged above the vibrating member (220) for limiting the upward movement amplitude of the vibrating member (220); and/or the lower limit seat (530) is arranged below the vibrating piece (220) and used for limiting the downward movement amplitude of the vibrating piece (220).
6. A seed forming device according to claim 1, further comprising a seed collecting unit (600), wherein the seed collecting unit (600) comprises a collecting pipe (610) and a collecting bottle (620), the collecting pipe (610) is connected to the collecting bottle (620), and one end of the collecting pipe (610) outside the collecting bottle (620) can be correspondingly arranged below the forming cavity (321).
7. A seed source molding device according to claim 3, wherein the extrusion unit (400) further comprises an upper needle seat (440), the upper needle driving telescopic rod (420) and the upper ejector rod (430) are connected through the upper needle seat (440), a positioning rod (441) is arranged on the upper needle seat (440), and the positioning rod (441) below the upper needle seat (440) is arranged in the positioning hole of the molding seat (330); the positioning rod (441) is used for fixing the relative position of the upper ejector rod (430) and the forming seat (330) in the horizontal direction.
8. A seed source forming device according to claim 5, wherein the limiting unit (500) further comprises a limiting driving cylinder (510) and a limiting telescopic rod (520), the limiting driving cylinder (510) drives the limiting telescopic rod (520) to move up and down, and one end of the limiting telescopic rod (520) far away from the limiting driving cylinder (510) is connected with the upper limiting block (521).
9. A seed forming device according to claim 6, wherein the seed collecting unit (600) further comprises a collecting motor (630) and a driving rod (631), the collecting motor (630) drives the driving rod (631) to move, and the driving rod (631) is used for driving one end of the collecting pipe (610) outside the collecting bottle (620) to move.
10. A seed forming device according to any one of claims 1 to 9, further comprising a frame (100), wherein the frame (100) comprises a base (110) and a support (120), the support (120) is vertically disposed on the base (110), and a supporting plate (121) is disposed at the top end of the support (120); wherein
A shaft seat (210) of the vibration unit (200) is arranged on the base (110), and a vibration wheel (230) and a vibration motor (231) are supported by a support (120);
or the supporting plate (121) is provided with a first through hole (131), and the first through hole (131) is used for supporting and fixing the limiting unit (500);
or the support plate (121) is provided with a second through hole (132), and the second through hole (132) is used for supporting and fixing the extrusion unit (400);
or the lower needle driving motor (341) of the seed source molding unit (300) is arranged on the base (110).
CN202010816516.9A 2020-08-14 2020-08-14 Seed source forming device Pending CN111789766A (en)

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Application Number Priority Date Filing Date Title
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Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1668439A (en) * 2002-07-19 2005-09-14 Smi有限公司 Method and apparatus for making miniature tablets
CN101474133A (en) * 2008-12-26 2009-07-08 东南大学 Device for automatically molding millimeter pills
CN102436860A (en) * 2011-08-16 2012-05-02 中国工程物理研究院核物理与化学研究所 Automatic production equipment for medical radioactive seed source
CN207236983U (en) * 2017-03-27 2018-04-17 深圳市九明药业有限公司 A kind of efficiently Desloratadine capsule compression assemblies
CN209097042U (en) * 2018-10-31 2019-07-12 北京中锐和科技发展有限公司 A kind of blanking device of sealed seed source
CN111437007A (en) * 2020-04-03 2020-07-24 北京中科生仪科技有限公司 Ultrasonic structure

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1668439A (en) * 2002-07-19 2005-09-14 Smi有限公司 Method and apparatus for making miniature tablets
CN101474133A (en) * 2008-12-26 2009-07-08 东南大学 Device for automatically molding millimeter pills
CN102436860A (en) * 2011-08-16 2012-05-02 中国工程物理研究院核物理与化学研究所 Automatic production equipment for medical radioactive seed source
CN207236983U (en) * 2017-03-27 2018-04-17 深圳市九明药业有限公司 A kind of efficiently Desloratadine capsule compression assemblies
CN209097042U (en) * 2018-10-31 2019-07-12 北京中锐和科技发展有限公司 A kind of blanking device of sealed seed source
CN111437007A (en) * 2020-04-03 2020-07-24 北京中科生仪科技有限公司 Ultrasonic structure

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