CN111789119A - 一种吡啶酮类抗真菌医药在农作物病害防治上的新用途 - Google Patents
一种吡啶酮类抗真菌医药在农作物病害防治上的新用途 Download PDFInfo
- Publication number
- CN111789119A CN111789119A CN202010767830.2A CN202010767830A CN111789119A CN 111789119 A CN111789119 A CN 111789119A CN 202010767830 A CN202010767830 A CN 202010767830A CN 111789119 A CN111789119 A CN 111789119A
- Authority
- CN
- China
- Prior art keywords
- antifungal
- pyridone
- pyridinone
- diseases caused
- hydroxypyrrolidone
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 201000010099 disease Diseases 0.000 title claims abstract description 23
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title claims abstract description 23
- 239000003814 drug Substances 0.000 title claims abstract description 23
- 229940121375 antifungal agent Drugs 0.000 title claims abstract description 22
- 230000000843 anti-fungal effect Effects 0.000 title claims abstract description 20
- UBQKCCHYAOITMY-UHFFFAOYSA-N pyridin-2-ol Chemical compound OC1=CC=CC=N1 UBQKCCHYAOITMY-UHFFFAOYSA-N 0.000 title claims description 12
- MBRHNTMUYWQHMR-UHFFFAOYSA-N 2-aminoethanol;6-cyclohexyl-1-hydroxy-4-methylpyridin-2-one Chemical group NCCO.ON1C(=O)C=C(C)C=C1C1CCCCC1 MBRHNTMUYWQHMR-UHFFFAOYSA-N 0.000 claims abstract description 21
- 229960004375 ciclopirox olamine Drugs 0.000 claims abstract description 21
- JQBCKRZQAMELAD-UHFFFAOYSA-N 1-hydroxypyrrolidin-2-one Chemical compound ON1CCCC1=O JQBCKRZQAMELAD-UHFFFAOYSA-N 0.000 claims abstract description 16
- 230000000844 anti-bacterial effect Effects 0.000 claims abstract description 14
- LVWZTYCIRDMTEY-UHFFFAOYSA-N metamizole Chemical compound O=C1C(N(CS(O)(=O)=O)C)=C(C)N(C)N1C1=CC=CC=C1 LVWZTYCIRDMTEY-UHFFFAOYSA-N 0.000 claims abstract description 10
- 241000207199 Citrus Species 0.000 claims abstract description 9
- 239000003899 bactericide agent Substances 0.000 claims abstract description 9
- 235000020971 citrus fruits Nutrition 0.000 claims abstract description 9
- 241000123650 Botrytis cinerea Species 0.000 claims abstract description 8
- 241000221696 Sclerotinia sclerotiorum Species 0.000 claims abstract description 8
- 241000223195 Fusarium graminearum Species 0.000 claims abstract description 7
- 241000223221 Fusarium oxysporum Species 0.000 claims abstract description 7
- 241000813090 Rhizoctonia solani Species 0.000 claims abstract description 7
- 241001330975 Magnaporthe oryzae Species 0.000 claims abstract description 6
- 230000002265 prevention Effects 0.000 claims abstract description 5
- 244000052769 pathogen Species 0.000 claims description 2
- 239000003429 antifungal agent Substances 0.000 claims 2
- RSNWORHVUOZYLT-UHFFFAOYSA-N 5-[[(2-sulfanylidene-3h-1,3,4-thiadiazol-5-yl)amino]methylamino]-3h-1,3,4-thiadiazole-2-thione Chemical compound S1C(=S)NN=C1NCNC1=NNC(=S)S1 RSNWORHVUOZYLT-UHFFFAOYSA-N 0.000 abstract description 4
- 239000005730 Azoxystrobin Substances 0.000 abstract description 4
- WFDXOXNFNRHQEC-GHRIWEEISA-N azoxystrobin Chemical compound CO\C=C(\C(=O)OC)C1=CC=CC=C1OC1=CC(OC=2C(=CC=CC=2)C#N)=NC=N1 WFDXOXNFNRHQEC-GHRIWEEISA-N 0.000 abstract description 4
- 240000007594 Oryza sativa Species 0.000 abstract description 2
- 235000007164 Oryza sativa Nutrition 0.000 abstract description 2
- 235000009566 rice Nutrition 0.000 abstract description 2
- 230000002401 inhibitory effect Effects 0.000 description 8
- 229940079593 drug Drugs 0.000 description 6
- 239000000243 solution Substances 0.000 description 6
- 241000196324 Embryophyta Species 0.000 description 4
- 230000001580 bacterial effect Effects 0.000 description 4
- 244000052616 bacterial pathogen Species 0.000 description 4
- 244000000005 bacterial plant pathogen Species 0.000 description 4
- 244000000004 fungal plant pathogen Species 0.000 description 4
- 239000001963 growth medium Substances 0.000 description 4
- LIPRKYKMVQPYPG-UHFFFAOYSA-N 3-Hydroxy-2H-pyran-2-one Chemical compound OC1=CC=COC1=O LIPRKYKMVQPYPG-UHFFFAOYSA-N 0.000 description 3
- 208000035143 Bacterial infection Diseases 0.000 description 3
- 241000233866 Fungi Species 0.000 description 3
- 208000031888 Mycoses Diseases 0.000 description 3
- 150000001875 compounds Chemical class 0.000 description 3
- 238000011161 development Methods 0.000 description 3
- 238000000034 method Methods 0.000 description 3
- 239000000575 pesticide Substances 0.000 description 3
- 239000000126 substance Substances 0.000 description 3
- 241000894006 Bacteria Species 0.000 description 2
- 230000003385 bacteriostatic effect Effects 0.000 description 2
- 238000004166 bioassay Methods 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 235000013305 food Nutrition 0.000 description 2
- 230000002538 fungal effect Effects 0.000 description 2
- 239000000417 fungicide Substances 0.000 description 2
- 238000011534 incubation Methods 0.000 description 2
- 230000005764 inhibitory process Effects 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 231100000053 low toxicity Toxicity 0.000 description 2
- 230000003032 phytopathogenic effect Effects 0.000 description 2
- 238000007619 statistical method Methods 0.000 description 2
- 241001480043 Arthrodermataceae Species 0.000 description 1
- 206010005913 Body tinea Diseases 0.000 description 1
- 241000222122 Candida albicans Species 0.000 description 1
- 241000588923 Citrobacter Species 0.000 description 1
- 208000002474 Tinea Diseases 0.000 description 1
- 208000007712 Tinea Versicolor Diseases 0.000 description 1
- 206010067197 Tinea manuum Diseases 0.000 description 1
- 206010056131 Tinea versicolour Diseases 0.000 description 1
- 241000209140 Triticum Species 0.000 description 1
- 235000021307 Triticum Nutrition 0.000 description 1
- 206010046914 Vaginal infection Diseases 0.000 description 1
- 238000002835 absorbance Methods 0.000 description 1
- 239000012871 anti-fungal composition Substances 0.000 description 1
- 238000011482 antibacterial activity assay Methods 0.000 description 1
- 238000011483 antifungal activity assay Methods 0.000 description 1
- 238000002815 broth microdilution Methods 0.000 description 1
- 229940095731 candida albicans Drugs 0.000 description 1
- 210000000170 cell membrane Anatomy 0.000 description 1
- 235000013339 cereals Nutrition 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 229960003749 ciclopirox Drugs 0.000 description 1
- SCKYRAXSEDYPSA-UHFFFAOYSA-N ciclopirox Chemical compound ON1C(=O)C=C(C)C=C1C1CCCCC1 SCKYRAXSEDYPSA-UHFFFAOYSA-N 0.000 description 1
- 230000037304 dermatophytes Effects 0.000 description 1
- 238000007865 diluting Methods 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
- 244000053095 fungal pathogen Species 0.000 description 1
- 230000000855 fungicidal effect Effects 0.000 description 1
- 230000009036 growth inhibition Effects 0.000 description 1
- 230000003834 intracellular effect Effects 0.000 description 1
- 239000006994 mh medium Substances 0.000 description 1
- 230000001717 pathogenic effect Effects 0.000 description 1
- 230000035699 permeability Effects 0.000 description 1
- 239000013641 positive control Substances 0.000 description 1
- 239000002243 precursor Substances 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 238000012827 research and development Methods 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 201000003875 tinea corporis Diseases 0.000 description 1
- 201000004647 tinea pedis Diseases 0.000 description 1
- 230000000699 topical effect Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/34—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom
- A01N43/40—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom six-membered rings
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Agronomy & Crop Science (AREA)
- Pest Control & Pesticides (AREA)
- Plant Pathology (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Dentistry (AREA)
- General Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Environmental Sciences (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
本发明公开了一种吡啶酮类抗真菌医药为杀菌剂在农作物病害防治上的新用途，所述的吡啶酮类抗真菌医药为环吡酮胺和羟吡酮，可防治由立枯丝核菌、油菜菌核病菌、番茄灰霉病菌、小麦赤霉病菌、稻瘟病菌、棉花枯萎病菌和柑橘溃疡病菌引起的农作物病害。本发明的环吡酮胺和羟吡酮对油菜菌核病菌、立枯丝核菌、番茄灰霉病菌、小麦赤霉病菌、稻瘟病菌、棉花枯萎病菌和柑橘溃疡病菌均表现出优异的抗菌作用，显著高于商品化杀菌剂嘧菌酯和叶枯唑，在农作物病害防治上表现出潜在的应用前景。
Description
技术领域
本发明涉及农用杀菌剂领域，更具体地，涉及吡啶酮类抗真菌医药作为杀菌剂在农作物病害防治上的新用途。
背景技术
植物病害严重威胁农业健康发展和粮食安全问题，因植物病害每年造成的粮食损失已超过产量的11％。比如我国稻田受到纹枯病的影响，每年造成600万吨谷物的损失，小麦受赤霉病的影响，每年造成10％～30％的减产。植物病害的严重发生、病原菌抗性的发展以及化学杀菌剂的滥用等，加剧植物病原菌对杀菌剂的抗性，严重威胁环境安全和人类健康。因此研究与开发能有效控制植物病原菌的高效、低毒、低残留的新型农药，已成为目前农药创制的首要目标。
环吡酮胺和羟吡酮(结构式如式1所示)是一种吡啶酮类抗真菌医药，主要改变真菌细胞膜的完整性，引起细胞内物质外流，并阻断蛋白质前体物质的摄取，导致真菌死亡。具有抗菌谱广、强渗透力。安全高效等特点，能直达被感染皮肤深部，对大多数的病原性霉菌，包括皮肤真菌、白色念珠菌等具有良好的抗菌活性，适用于手足癣、体癣及花斑癣，也可用于霉菌性阴道感染的治疗，是目前较为理想的局部用抗真菌药。但到目前为止，还未见环吡酮胺和羟吡酮在防治植物病害方面的研究报道。基于此，本发明以环吡酮胺和羟吡酮为供试药剂，评价其对植物病原真菌和植物病原细菌的抗菌活性，发现环吡酮胺和羟吡酮对油菜菌核病菌，立枯丝核菌、番茄灰霉病菌、小麦赤霉病菌、稻瘟病菌、棉花枯萎病菌和柑橘溃疡病菌均具有优异的抗菌活性。因此，环吡酮胺和羟吡酮作为防治重要农作物病害的杀菌剂有良好的开发前景。
发明内容
本发明的目的是将2种吡啶酮类药剂用于农作物病害的防治，以扩大各药剂的使用范围，以期筛选到一些高效、低毒的农药杀菌剂。
吡啶酮类抗真菌医药作为杀菌剂在农作物病害防治上的新用途，所述的吡啶酮类抗真菌医药为环吡酮胺和羟吡酮，可防治由油菜菌核病菌、立枯丝核病菌、番茄灰霉病菌、小麦赤霉病菌、稻瘟病菌、棉花枯萎病菌引起的农作物真菌病害，可防治由柑橘溃疡病菌引起的农作物细菌性病害。
与现有技术相比，本发明的效果是：吡啶酮类抗真菌医药(环吡酮胺和羟吡酮)对多种农作物真菌和细菌病害的活性显著高于农用商品化杀菌剂嘧菌酯和叶枯唑，可以在农业农作物病害防治上实现新用途。
具体实施方式
吡啶酮类抗真菌医药作为杀菌剂在农作物病害防治上的新用途，所述的吡啶酮类抗真菌医药为环吡酮胺和羟吡酮，可防治由油菜菌核病菌、立枯丝核病菌、番茄灰霉病菌、小麦赤霉病菌、稻瘟病菌、棉花枯萎病菌引起的农作物真菌病害，可防治由柑橘溃疡病菌引起的农作物细菌性病害。
以下是本发明的具体实施例，对本发明的技术方案做进一步描述，但本发明的内容不仅仅局限于实施例所述的范围，凡是不背离本发明构思的改变或等同替代均包括在本发明的保护范围之内。
实施例1：室内抗真菌活性测定
采用菌丝生长速率法：按照一定的浓度梯度，将测试化合物加入经灭菌并冷却至50℃左右的培养基中，混匀，将药剂稀释成系列浓度制备成含药培养基，每培养皿接种一菌碟(直径d＝5mm)，每个浓度设置3个重复；并以嘧菌酯为对照药剂，测定化合物对6种植物病原真菌的抑制活性。在25℃培养至对照菌落长满培养皿2/3以上时以十字交叉法测定各浓度处理的菌落直径(mm)，计算药剂对菌丝体的生长抑制率，差异性统计分析采用统计软件SAS8.1(Statistical Analysis System 8.1)进行。测定环吡酮胺和羟吡酮对6种植物病原真菌的抑制效果，结果见表1和表3。
实施例2：室内抗细菌活性测定
采用微量肉汤稀释法：将柑橘溃疡病菌接种于20mL MH培养基中，然后置于37℃的恒温摇床中孵育12h，转速为150rpm。取适量菌体培养液用酶标仪测定在600nm下的吸光度，以不加细菌的培养液作为空白对照，根据OD6000.1相当于浓度为1×108cfu/mL，用MH培养基将细菌悬浮液稀释成浓度1×106cfu/mL的菌液后，备用。
用排枪吸取50μL稀释好的细菌菌液置于96孔板中，然后依次加入50μL的化合物溶液，空白对照为加入同等体积的PBS溶液，阳性对照为叶枯唑，每个浓度设置3个重复。将样品置于28℃的恒温培养箱中孵育24h后，测定其在600nm处的OD值，计算出抑制率，并用SPSS软件计算出抑制中浓度EC50。测定环吡酮胺和羟吡酮对柑橘溃疡病菌的抑制效果，结果见表2和表3。
表1.环吡酮胺和羟吡酮对植物病原真菌的抑制活性
表2.环吡酮胺和羟吡酮对柑橘溃疡病菌的抑制活性
表3.环吡酮胺和羟吡酮对植物病原真菌的抑制活性
由表1和表3生测结果可知，本发明涉及的2种吡啶酮类抗真菌医药(环吡酮胺和羟吡酮)对6种植物病原真菌，油菜菌核病菌、立枯丝核菌、番茄灰霉病菌、小麦赤霉病菌、稻瘟病菌和棉花枯萎病菌均表现出优异的抑制作用，显著高于同浓度下的商品化杀菌剂嘧菌酯。特别是环吡酮胺对油菜菌核病菌、番茄灰霉病菌的抑菌活性最强，其EC50值分别为1.95和5.37μg/mL。由表2和表3生测结果可知，环吡酮胺和羟吡酮对植物病原细菌，柑橘溃疡病菌的抑菌活性较强，其EC50值分别为15.43和29.61μg/mL，显著高于对照药剂叶枯唑。综上所述，本发明所述的吡啶酮类抗真菌医药对农业病菌表现出显著的抑制活性，可以在农作物病害防治上实现新用途。
Claims (8)
1.本发明涉及一种吡啶酮类抗真菌医药作为杀菌剂在农作物病害防治上的新用途，其特征在于：所述的吡啶酮类抗真菌医药为环吡酮胺和羟吡酮。
2.根据权利要求1所述的吡啶酮类抗真菌医药在防治油菜菌核病菌引起的病害中的应用。
3.根据权利要求1所述的吡啶酮类抗真菌医药在防治立枯丝核菌引起的病害中的应用。
4.根据权利要求1所述的吡啶酮类抗真菌医药在防治番茄灰霉病菌引起的病害中的应用。
5.根据权利要求1所述的吡啶酮类抗真菌医药在防治小麦赤霉病菌引起的病害中的应用。
6.根据权利要求1所述的吡啶酮类抗真菌医药在防治稻瘟病菌引起的病害中的应用。
7.根据权利要求1所述的吡啶酮类抗真菌医药在防治棉花枯萎病菌引起的病害中的应用。
8.根据权利要求1所述的吡啶酮类抗真菌医药在防治柑橘溃疡病菌引起的病害中的应用。
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202010767830.2A CN111789119A (zh) | 2020-08-03 | 2020-08-03 | 一种吡啶酮类抗真菌医药在农作物病害防治上的新用途 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202010767830.2A CN111789119A (zh) | 2020-08-03 | 2020-08-03 | 一种吡啶酮类抗真菌医药在农作物病害防治上的新用途 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN111789119A true CN111789119A (zh) | 2020-10-20 |
Family
ID=72827505
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202010767830.2A Pending CN111789119A (zh) | 2020-08-03 | 2020-08-03 | 一种吡啶酮类抗真菌医药在农作物病害防治上的新用途 |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN111789119A (zh) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115735929A (zh) * | 2022-11-02 | 2023-03-07 | 成都新朝阳作物科学股份有限公司 | 吡啶酮乙醇铵盐的应用、制剂及制备方法 |
Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20100324077A1 (en) * | 2008-02-06 | 2010-12-23 | Jan Pieter Hendrik Bosselaers | Combinations of anilinopyrimidines and pyrion compounds |
| CN101932243A (zh) * | 2008-02-06 | 2010-12-29 | 詹森药业有限公司 | 苯基吡咯和吡啶酮*化合物的组合 |
| US20110092550A1 (en) * | 2007-08-31 | 2011-04-21 | Jan Pieter Hendrik Bosselaers | Combinations of imazalil and hydroxypyridones |
| CN102821744A (zh) * | 2010-03-29 | 2012-12-12 | 拜尔斯道夫股份有限公司 | 微生物稳定的易应用的制剂 |
| EP3360860A1 (en) * | 2015-10-09 | 2018-08-15 | Mitsui Chemicals Agro, Inc. | Pyridone compound and agricultural/horticultural bactericide including same as active ingredient |
| US20180271092A1 (en) * | 2015-10-30 | 2018-09-27 | Agrobiologics, Llc | Use of the antifungal ilicicolin h in agriculture |
| CN110622973A (zh) * | 2019-11-06 | 2019-12-31 | 海南大学 | 1-芳基-4-吡啶酮类化合物的应用 |
| US20200045963A1 (en) * | 2017-04-10 | 2020-02-13 | Mitsui Chemicals Agro, Inc. | Pyridone compounds and agricultural and horticultural fungicides comprising the same as active ingredients |
-
2020
- 2020-08-03 CN CN202010767830.2A patent/CN111789119A/zh active Pending
Patent Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20110092550A1 (en) * | 2007-08-31 | 2011-04-21 | Jan Pieter Hendrik Bosselaers | Combinations of imazalil and hydroxypyridones |
| US20100324077A1 (en) * | 2008-02-06 | 2010-12-23 | Jan Pieter Hendrik Bosselaers | Combinations of anilinopyrimidines and pyrion compounds |
| CN101932243A (zh) * | 2008-02-06 | 2010-12-29 | 詹森药业有限公司 | 苯基吡咯和吡啶酮*化合物的组合 |
| CN102821744A (zh) * | 2010-03-29 | 2012-12-12 | 拜尔斯道夫股份有限公司 | 微生物稳定的易应用的制剂 |
| EP3360860A1 (en) * | 2015-10-09 | 2018-08-15 | Mitsui Chemicals Agro, Inc. | Pyridone compound and agricultural/horticultural bactericide including same as active ingredient |
| US20180271092A1 (en) * | 2015-10-30 | 2018-09-27 | Agrobiologics, Llc | Use of the antifungal ilicicolin h in agriculture |
| US20200045963A1 (en) * | 2017-04-10 | 2020-02-13 | Mitsui Chemicals Agro, Inc. | Pyridone compounds and agricultural and horticultural fungicides comprising the same as active ingredients |
| CN110622973A (zh) * | 2019-11-06 | 2019-12-31 | 海南大学 | 1-芳基-4-吡啶酮类化合物的应用 |
Non-Patent Citations (3)
| Title |
|---|
| LU, YU: "High-throughput screening reveals small molecule modulators inhibitory to Acidovorax citrulli", PLANT PATHOLOGY, vol. 69, no. 5, 30 June 2020 (2020-06-30), pages 818 - 826 * |
| 周云;张智平;涂晓嵘;涂国全;: "农抗702抗真菌活性的测定", 江西农业大学学报, no. 06, 20 December 2009 (2009-12-20) * |
| 朱国仁: "《实用蔬菜病虫防治手册》", 31 October 1997, 北京：中国林业出版社, pages: 97 - 98 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115735929A (zh) * | 2022-11-02 | 2023-03-07 | 成都新朝阳作物科学股份有限公司 | 吡啶酮乙醇铵盐的应用、制剂及制备方法 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN112385659A (zh) | 二硫键化合物在防治微生物病害中的应用 | |
| CN110622975B (zh) | 咪康唑在制备用于防治植物病原菌的杀菌剂中的应用 | |
| CN111789119A (zh) | 一种吡啶酮类抗真菌医药在农作物病害防治上的新用途 | |
| CN112998028B (zh) | 一种金属-丙硫菌唑纳米农药及其制备方法和应用 | |
| CN111436428A (zh) | 萘苄胺类抗真菌药物在防治农业病害中的用途 | |
| CN104705324B (zh) | 一种含中生菌素和壳寡糖的杀菌组合物 | |
| CN105815326B (zh) | 含小白菊内酯的农用杀菌剂制备方法及其用途 | |
| CN112715541A (zh) | 啤酒花中黄腐醇和异黄腐酚在防治农业病害中的用途 | |
| CN105028435B (zh) | 一种天然化合物作为农业杀菌剂的用途 | |
| CN111937886A (zh) | 一种8-羟基喹啉配合物的制备及其在防治植物病害中的用途 | |
| CN113875779B (zh) | 杀菌剂组合物及其制备方法 | |
| CN105219678A (zh) | 一株成团泛菌及其应用 | |
| CN114304161A (zh) | 三氯苯达唑在防治农业病原菌中的用途 | |
| CN113180050B (zh) | 胡椒碱作为农业杀菌剂的用途 | |
| CN113180042A (zh) | 丹皮酚作为农业杀菌剂的用途 | |
| CN110547296A (zh) | 白术内酯i及其类似物在防治农业病害中的应用 | |
| CN101849608B (zh) | 油菜饼抗菌肽 | |
| CN116849216A (zh) | 一种异甜菊醇衍生物在防治植物病害中的用途 | |
| CN110742076A (zh) | 甘草苷在防治作物卵菌及真菌病害中的用途 | |
| CN114041461A (zh) | 双氯酚在防治农业病原菌中的用途 | |
| CN114009440A (zh) | 阿巴芬净在防治农业病原菌中的用途 | |
| CN114027310A (zh) | 一种硫代氨基甲酸类化合物在防治农业病原真菌中的用途 | |
| CN113197214B (zh) | 汉防己甲素作为农业杀菌剂的用途 | |
| CN114304154A (zh) | 羰基氰化氯苯腙在防治农业病原菌中的用途 | |
| CN116941614A (zh) | 一种甜菊醇衍生物在防治植物病害中的用途 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination |