CN111787920A - 用于控制和/或降低近视发展的药物组合物 - Google Patents

用于控制和/或降低近视发展的药物组合物 Download PDF

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Publication number
CN111787920A
CN111787920A CN201880085219.2A CN201880085219A CN111787920A CN 111787920 A CN111787920 A CN 111787920A CN 201880085219 A CN201880085219 A CN 201880085219A CN 111787920 A CN111787920 A CN 111787920A
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CN
China
Prior art keywords
pharmaceutical composition
ophthalmic
eye
atropine
myopia
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201880085219.2A
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English (en)
Chinese (zh)
Inventor
米纳斯·希欧多尔·科罗内奥
莫尼卡·钟
P·R·桑卡里杜尔格
E·L·史密斯三世
阿曼迪普·考尔
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Warbone Vision Research Center Co ltd
Original Assignee
Warbone Vision Research Center Co ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Warbone Vision Research Center Co ltd filed Critical Warbone Vision Research Center Co ltd
Priority to CN202410507498.4A priority Critical patent/CN118384160A/zh
Priority to CN202410507406.2A priority patent/CN118403054A/zh
Publication of CN111787920A publication Critical patent/CN111787920A/zh
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/46—8-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
    • A61K31/522—Purines, e.g. adenine having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/38—Cellulose; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A61K9/0051—Ocular inserts or implants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/10—Ophthalmic agents for accommodation disorders, e.g. myopia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Emergency Medicine (AREA)
  • Inorganic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CN201880085219.2A 2017-11-03 2018-11-02 用于控制和/或降低近视发展的药物组合物 Pending CN111787920A (zh)

Priority Applications (2)

Application Number Priority Date Filing Date Title
CN202410507498.4A CN118384160A (zh) 2017-11-03 2018-11-02 用于控制和/或降低近视发展的药物组合物
CN202410507406.2A CN118403054A (zh) 2017-11-03 2018-11-02 用于控制和/或降低近视发展的药物组合物

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762581112P 2017-11-03 2017-11-03
US62/581,112 2017-11-03
PCT/AU2018/051187 WO2019084621A1 (en) 2017-11-03 2018-11-02 Pharmaceutical compositions for controlling and/or reducing the progression of myopia

Related Child Applications (2)

Application Number Title Priority Date Filing Date
CN202410507406.2A Division CN118403054A (zh) 2017-11-03 2018-11-02 用于控制和/或降低近视发展的药物组合物
CN202410507498.4A Division CN118384160A (zh) 2017-11-03 2018-11-02 用于控制和/或降低近视发展的药物组合物

Publications (1)

Publication Number Publication Date
CN111787920A true CN111787920A (zh) 2020-10-16

Family

ID=66331107

Family Applications (3)

Application Number Title Priority Date Filing Date
CN201880085219.2A Pending CN111787920A (zh) 2017-11-03 2018-11-02 用于控制和/或降低近视发展的药物组合物
CN202410507406.2A Pending CN118403054A (zh) 2017-11-03 2018-11-02 用于控制和/或降低近视发展的药物组合物
CN202410507498.4A Pending CN118384160A (zh) 2017-11-03 2018-11-02 用于控制和/或降低近视发展的药物组合物

Family Applications After (2)

Application Number Title Priority Date Filing Date
CN202410507406.2A Pending CN118403054A (zh) 2017-11-03 2018-11-02 用于控制和/或降低近视发展的药物组合物
CN202410507498.4A Pending CN118384160A (zh) 2017-11-03 2018-11-02 用于控制和/或降低近视发展的药物组合物

Country Status (10)

Country Link
US (1) US20200345633A1 (https=)
EP (1) EP3703691A4 (https=)
JP (2) JP2021501803A (https=)
KR (1) KR20200088824A (https=)
CN (3) CN111787920A (https=)
AU (1) AU2018359013A1 (https=)
CA (1) CA3081593A1 (https=)
SG (1) SG11202004005RA (https=)
TW (1) TW201932104A (https=)
WO (1) WO2019084621A1 (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN119139472A (zh) * 2024-09-26 2024-12-17 温州医科大学附属眼视光医院 腺苷信号阻滞剂在制备治疗弱视和改善视觉可塑性的药物中的应用

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3763280A1 (de) * 2019-07-11 2021-01-13 Carl Zeiss Vision International GmbH Bestimmung einer veränderung eines refraktionsfehlers eines auges
US11191751B1 (en) * 2020-10-08 2021-12-07 Ads Therapeutics Llc Topical ophthalmological atropine free base compositions
CN114306331B (zh) * 2020-10-10 2023-07-18 远大生命科学(武汉)有限公司 戊乙奎醚在治疗或预防视力损伤性眼部疾病中的用途
US20240261291A1 (en) * 2021-06-11 2024-08-08 Brien Holden Vision Institute Limited Ophthalmic Compositions and/or Methods for Presbyopia, Mydriasis and/or Ocular Discomfort Management
WO2025259674A1 (en) * 2024-06-11 2025-12-18 Ads Therapeutics Llc Compositions and methods for delivery of pharmaceutical actives

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996031222A1 (en) * 1994-03-23 1996-10-10 Ivan Dimitrov Hristov Antiasthmatic preparation
US5574044A (en) * 1994-10-27 1996-11-12 Merck & Co., Inc. Muscarine antagonists
US6710051B1 (en) * 1997-01-06 2004-03-23 Klaus Trier Aps Screening method
WO2012161655A1 (en) * 2011-05-23 2012-11-29 Singapore Health Services Pte Ltd Composition and/or method for reducing and/or preventing myopia progression comprising atropine

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995033451A1 (en) * 1994-06-06 1995-12-14 Warner-Lambert Company Non-sedating allergy sinus medication
LT2493474T (lt) * 2009-10-30 2019-10-10 Intratus, Inc. Būdai ir kompozicijos prolonguotam vaistų įvedimui
JP5993620B2 (ja) * 2011-06-01 2016-09-14 ロート製薬株式会社 点眼剤
WO2016172712A2 (en) * 2015-04-23 2016-10-27 Sydnexis, Inc. Ophthalmic composition

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996031222A1 (en) * 1994-03-23 1996-10-10 Ivan Dimitrov Hristov Antiasthmatic preparation
US5574044A (en) * 1994-10-27 1996-11-12 Merck & Co., Inc. Muscarine antagonists
US6710051B1 (en) * 1997-01-06 2004-03-23 Klaus Trier Aps Screening method
WO2012161655A1 (en) * 2011-05-23 2012-11-29 Singapore Health Services Pte Ltd Composition and/or method for reducing and/or preventing myopia progression comprising atropine

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN119139472A (zh) * 2024-09-26 2024-12-17 温州医科大学附属眼视光医院 腺苷信号阻滞剂在制备治疗弱视和改善视觉可塑性的药物中的应用

Also Published As

Publication number Publication date
AU2018359013A1 (en) 2020-05-21
CN118384160A (zh) 2024-07-26
JP2023179418A (ja) 2023-12-19
SG11202004005RA (en) 2020-05-28
WO2019084621A1 (en) 2019-05-09
US20200345633A1 (en) 2020-11-05
EP3703691A1 (en) 2020-09-09
JP2021501803A (ja) 2021-01-21
EP3703691A4 (en) 2021-07-28
KR20200088824A (ko) 2020-07-23
TW201932104A (zh) 2019-08-16
CA3081593A1 (en) 2019-05-09
CN118403054A (zh) 2024-07-30

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