CN111784103B - Reagent quality whole-flow management system based on blockchain technology - Google Patents

Reagent quality whole-flow management system based on blockchain technology Download PDF

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CN111784103B
CN111784103B CN202010443068.2A CN202010443068A CN111784103B CN 111784103 B CN111784103 B CN 111784103B CN 202010443068 A CN202010443068 A CN 202010443068A CN 111784103 B CN111784103 B CN 111784103B
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康雅婷
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Shanghai Flying Fish Medical Technology Co ltd
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Abstract

The invention relates to the field of reagent detection, in particular to a reagent quality whole-flow management system based on a blockchain technology. Comprising the following steps: the first-stage management nodes receive the parameters output by all the detection nodes in each first network, judge the parameters to obtain first judgment results, and feed back the first judgment results to different detection nodes; in each first network, each detection node is used for recording parameters sent to the first-stage management node by all other detection nodes; and the second-stage management node receives all the first judgment results in the second network, judges to obtain second judgment results, feeds back the second judgment results to the first-stage management node, and feeds back the second judgment results to different detection nodes. The beneficial effects of the technical scheme are as follows: the method effectively solves the existing various monitoring defects of the medical inspection reagent domain, safely and efficiently monitors the whole-course quality of the reagent, stores data in real time, analyzes risk, feeds back the data and encrypts and protects the reagent.

Description

Reagent quality whole-flow management system based on blockchain technology
Technical Field
The invention relates to the field of reagent detection, in particular to a reagent quality whole-flow management system based on a blockchain technology.
Background
In recent years, with the development of modern medical diagnosis technology, quality control of medical laboratory detection is increasingly emphasized, and quality control of medical diagnostic reagents is a guarantee of detection quality. However, the quality control system of the current medical diagnostic reagent has a plurality of defects and drawbacks, such as whole-course quality monitoring and standardization of the production, transportation and application of the diagnostic reagent, huge data are difficult to timely retrieve, risk analysis and early warning, and the like, and the construction of the blockchain system provides an effective method for whole-course quality control of the reagent.
The existing reagent monitoring system lacks a systematic whole-process monitoring system, and cannot timely feed back and correct the quality out of control and errors. The quality control data cannot be shared, resulting in repetitive detection. And the extraction of emergency detection data is very difficult to generate timely tracking due to too huge data.
Disclosure of Invention
In view of the above-mentioned drawbacks of the prior art, the present invention provides a total flow management system for quality of reagents based on a blockchain technology, which is characterized by comprising a plurality of different types of detection nodes, wherein the detection nodes are used for detecting parameters of the reagents in a total life cycle of the reagents, and each parameter is marked with a corresponding production lot of the reagents;
The reagent quality whole flow management system further comprises:
The first-stage management nodes are respectively integrated with part of the detection nodes to form a first network;
In each first network, the first-stage management node is configured to receive the parameters output by all the detection nodes and determine to obtain a first determination result, where the first-stage management node feeds back the first determination result to different detection nodes;
in each first network, each detection node is used for recording the parameters sent to the first-stage management node by all other detection nodes;
The second-level management node is integrated with all the first-level management nodes to form a second network;
In the second network, the second level management node is configured to receive all the first determination results and determine to obtain a second determination result, the second level management node feeds back the second determination result to the first level management node, and the first level management node feeds back the second determination result to different detection nodes.
Preferably, the types of the parameters include:
The production parameters are used for recording parameters obtained by the detection node of the first node type in the process of detecting the reagent production of the reagent;
the transportation parameter is used for recording parameters obtained by the detection node of the second node type in the process of detecting the transportation reagent of the reagent as the production parameter;
the agent parameter is used for recording parameters obtained by the detection node of the third node type in the agent selling process of detecting the reagent;
and the detection parameters are used for recording parameters obtained by the detection node of the fourth node type in the laboratory detection process of detecting the reagent.
Preferably, the production parameters include the actual detection calibration range of the reagent.
Preferably, the transportation parameters include temperature, time and degree of appearance breakage during transportation and storage of the reagent.
Preferably, the agent parameters include temperature, expiration date, and appearance breakage during agent storage of the agent.
Preferably, the detection parameter comprises an actual detection value of the reagent during an actual detection process.
Preferably, the types of the parameters further include:
and the standard substance parameters are used for recording parameters obtained by the detection node of the fifth node type in the process of detecting the standard substance, wherein the standard substance is one of the reagents used for detection.
Preferably, a first judgment rule is set in the first-stage management node, the first judgment rule sets a parameter threshold and a parameter deviation threshold corresponding to different types of parameters respectively, and the first-stage management node calculates a deviation value between the parameters and the parameter threshold and judges the deviation value;
When the deviation value exceeds the parameter deviation threshold, the first-stage management node includes the deviation value in a disqualified instruction and sends the disqualified instruction as the first judgment result to the detection node corresponding to the parameter;
And when the deviation value does not exceed the parameter deviation threshold value, the first-stage management node sends the deviation value to the detection node corresponding to the parameter as the first judgment result, wherein the deviation value is included in a qualified instruction.
Preferably, a second judging rule is set in the second management node, the second judging rule sets deviation indexes corresponding to different types of deviation values respectively, the second management node calculates an index difference value between the deviation value and the deviation index according to the deviation value in the first judging result, judges the index difference value to obtain the minimum index difference value, and includes the minimum index difference value and the parameter of the detection node corresponding to the index difference value in the second judging result, and feeds back the minimum index difference value and the parameter to different detection nodes through the first stage node.
Preferably, the reagent quality whole flow management system further comprises:
A plurality of detection center nodes, wherein a third judging rule is arranged in the detection center nodes, the third judging rule is provided with a disqualification threshold corresponding to reagents of different production batches, the detection center nodes are respectively connected with the first-stage management nodes, disqualification instructions in all the first judging results are received, all the disqualification instructions are judged according to the production batches,
When the number of the unqualified instructions exceeds the unqualified threshold, the detection center node generates a stop instruction and sends the stop instruction to a first-stage management node as a third judgment result;
The first level management node will stop the detection node from detecting the parameter of the reagent in the full life cycle of the corresponding reagent after receiving the stop instruction.
The beneficial effects of the technical scheme are as follows: the method effectively solves the existing various monitoring defects of the medical inspection reagent domain, safely and efficiently monitors the whole-course quality of the reagent, stores data in real time, analyzes risk, feeds back the data and encrypts and protects the reagent.
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FIG. 1 is a schematic diagram of a reagent quality overall process management system according to a preferred embodiment of the present invention.
Detailed Description
The following description of the embodiments of the present invention will be made clearly and completely with reference to the accompanying drawings, in which it is apparent that the embodiments described are only some embodiments of the present invention, but not all embodiments. All other embodiments, which can be made by those skilled in the art based on the embodiments of the invention without making any inventive effort, are intended to be within the scope of the invention.
It should be noted that, without conflict, the embodiments of the present invention and features of the embodiments may be combined with each other.
A reagent quality whole flow management system based on a blockchain technology is used for detecting the quality of a reagent, and as shown in fig. 1, comprises a plurality of detection nodes 01 of different types, wherein the detection nodes 01 are used for detecting parameters of the reagent in the whole life cycle of the reagent, and each parameter is marked with a corresponding production batch of the reagent;
the reagent quality whole flow management system further comprises:
the first-stage management nodes 1 are respectively integrated with part of the detection nodes 01 to form a first network;
In each first network, the first-stage management node 1 is configured to receive the parameters output by all the detection nodes 01 and determine to obtain a first determination result, where the first-stage management node 1 feeds back the first determination result to different detection nodes 01;
In each first network, each detection node 01 is used for recording parameters sent to the first-stage management node 1 by all other detection nodes 01;
A second-stage management node 2, wherein the second-stage management node 2 and all the first-stage management nodes 1 are integrated to form a second network;
In the second network, the second management node 2 is configured to receive all the first determination results and perform a determination to obtain a second determination result, where the second management node 2 feeds back the second determination result to the first management node 1, and the first management node 1 feeds back the second determination result to different detection nodes 01.
Specifically, the reagent needs to be confirmed to be used through a series of steps of production, transportation, storage and the like, however, in the series of steps, in order to discover the quality problem of the reagent in time, the energy consumption caused by the steps of production, transportation, storage and the like is reduced, a large number of repeated reagent detection data are simplified, a reagent quality whole-flow management system is constructed, parameters detected in the process of producing the reagent, parameters detected in the process of transporting the reagent, parameters detected in the process of selling the reagent by proxy, and parameters detected in the process of detecting in a laboratory are detected and transmitted through a detection node 01 in the reagent quality whole-flow management system, and judgment is carried out through a first-stage management node 1 and a second-stage management node 2.
In one embodiment, a detection node is used for detecting and analyzing reagents in different batches and detecting and analyzing the same batch of reagents in different detection nodes, so that the whole process monitoring of the reagents is realized, and workers can find out the problem of unqualified reagent quality in time.
Further, qualitative actual detection and quantitative actual analysis can be performed in the detection process, so that the reagent can be detected more comprehensively, effectively and accurately. In a preferred embodiment, the quantitative reagent analysis and qualitative detection are performed, wherein the quantitative detection can be performed by using Westgard rules, including six results: more than plus or minus 2S, more than plus or minus 3S, more than plus or minus 2S of two continuous quality control simultaneously, more than 4S of the highest lowest range of the same batch, more than plus or minus 1S of 4 continuous quality control simultaneously, and 10 continuous quality control at one side of the average value. By the rule, a range of control detection of the parameters of the reagent is realized, so that the quality detection of the reagent is realized.
Furthermore, the reagent quality whole-flow management system not only can realize the real-time monitoring of the whole flow of the reagent, but also can realize the data confidentiality of the detection result. For example, when a detecting party is taken as the detecting node 01 of the fourth node type and the detected parameter is output to the first-stage management node 1, the parameter is subjected to hash operation by using a hash function, a hash tree of a data structure of a binary tree is generated, and the transmitted parameter can resist malicious attack and tampering due to the attack resistance of the hash function, so that the detection result of the reagent can be prevented from being obtained and tampered by an outsider.
Further, in the process of production, transportation and the like, in order to timely correct the reagent, so as to avoid more economic losses, corresponding operators are respectively arranged at the detection nodes 01, and timely correct operations are performed according to the output detection parameters, such as formula configuration of the produced reagent, temperature, time and appearance damage degree in the transportation and storage process of the transported reagent, temperature, validity period and appearance damage degree in the agent storage process when the agent is sold, and the like.
Further, considering that different administration results are generated due to different physical conditions, allergic reactions and drug resistances of the user, in order to improve the safety usability of the reagent, the reagent usage feedback of the user can be used as the detection node 01 of the reagent quality whole-flow management system, and the user can output the usage experience after using the reagent to the first-stage management node 1 through a client terminal or the like, so that the correct and wrong conditions of each detection node 01 in the reagent quality whole-flow management system can be detected according to the usage experience, and the subtle differences of applicable people for judging the reagent can be improved more excellently.
Further, considering that the supply range of the reagent is wide, in order to simplify the data scale, reduce the resource consumption and improve the performance of the reagent quality whole-flow management system, the area range is used as a first network, such as a first network in eastern China, south China, north China, northwest China, southwest, northeast China and Taiwan and Hongkong Australia, and each corresponding first network comprises all detection nodes 01 in the corresponding area so as to avoid missing detection results in the transmission process.
In a preferred embodiment of the present invention, the types of parameters include:
the production parameters are used for recording parameters obtained by the detection node 01 of the first node type in the process of producing the detection reagent;
The transportation parameter is used for recording parameters obtained by the detection node 01 of the second node type in the process of transporting the detection reagent as production parameters;
The agent parameter is used for recording parameters obtained by the detection node 01 of the third node type in the agent selling process of the detection reagent;
and the detection parameter is used for recording the parameter of the detection node 01 of the fourth node type, which is obtained in the laboratory detection process of the detection reagent.
In a preferred embodiment of the invention, the production parameters include the actual detection calibration range of the reagent.
Specifically, in the process of generating the reagent, the production is performed in a detection calibration range, and because the components of the reagent are complex, a plurality of detection calibration ranges of different types are required, and correspondingly include: precision, accuracy, dilution, lower limit of detection, specificity, reproducibility, linearity, specificity, uncertainty, and the like.
In a preferred embodiment of the invention, the transportation parameters include temperature, time and degree of appearance breakage during transportation and storage of the reagent.
In particular, in the process of transporting the reagent, the reagent is considered to be stored in a container of the transport vehicle, so that the temperature, time and appearance damage degree in the process of transporting and storing the reagent need to be strictly controlled, and quality problems of the reagent caused by improper temperature are prevented.
In a preferred embodiment of the invention, the agent parameters include temperature, expiration date, and appearance breakage during agent storage of the agent.
Specifically, in the process of distributing the reagent by the actual agent, the temperature, the validity period and the appearance damage degree of the agent in the process of storing the reagent by the agent are strictly controlled so as to prevent the quality problem of the agent caused by improper temperature.
In a preferred embodiment of the invention, the detection parameter comprises an actual detection value of the reagent during an actual detection process.
Specifically, after the reagent is produced, transported and distributed in a proxy way, the standard value of the reagent is inevitably changed due to the inherent error of the equipment for producing the reagent, the change of the environment for storing and transporting the reagent, or the natural change of the components in the reagent, so that the actual detection value of the reagent is detected in the laboratory detection process of the reagent, and the actual detection value comprises: precision, accuracy, dilution, lower limit of detection, specificity, reproducibility, linearity, specificity, uncertainty, and the like.
In a preferred embodiment of the present invention, the types of parameters further include:
And the standard substance parameters are used for recording parameters obtained by the detection node 01 of the fifth node type in the process of detecting the standard substance, wherein the standard substance is one of the reagents for detection.
Specifically, the detection node 01 of the fifth node type uses the standard substance as a reference quantity to realize detection of the reagent.
In a preferred embodiment of the present invention, a first judgment rule is set in the first-stage management node 1, the first judgment rule sets a parameter threshold and a parameter deviation threshold corresponding to different types of parameters, the first-stage management node 1 calculates a deviation value between the parameters and the parameter threshold, and judges the deviation value;
When the deviation value exceeds the parameter deviation threshold, the first-stage management node 1 sends the deviation value to a detection node 01 corresponding to the parameter as a first judgment result, wherein the detection node 01 is used as a failure instruction;
when the deviation value does not exceed the parameter deviation threshold, the first-stage management node 1 sends the deviation value included in a qualified instruction as a first judgment result to the detection node 01 corresponding to the parameter.
Specifically, a first judgment rule is set in the first-stage management node 1, a parameter threshold and a deviation threshold are set according to the first judgment rule, and the current parameters of the reagent are judged, so that whether the reagent is qualified or not is judged.
Further, a reagent quality whole-flow management system is constructed, a plurality of first networks are divided in the management system, all parameters in the first networks are judged by the first management nodes and the first judgment rules, so that parameters generated in the detection process of the reagent are greatly simplified, the workload of judgment equipment is reduced, and the loss is reduced.
In a preferred embodiment of the present invention, a second judgment rule is set in the second management node 2, the second judgment rule sets deviation indexes corresponding to different types of deviation values respectively, the second management node 2 calculates an index difference between the deviation value and the deviation index according to the deviation value in the first judgment result, judges the index difference to obtain a minimum index difference, and includes the minimum index difference and the parameter of the detection node 01 corresponding to the index difference in the second judgment result, and feeds back the minimum index difference and the parameter to different detection nodes 01 through the first stage node.
Specifically, the second management node 2 sets a second judgment rule, and sets a deviation index according to the second judgment rule, so as to measure the deviation of the deviation value, thereby realizing the measurement and judgment of the production process of a plurality of first networks.
Further, since the management system is provided with the plurality of first networks, in the production process of the first networks, different settings of the reagents in the production, transportation and agent selling processes are considered, therefore, the deviation values in the first networks are measured through the second management node, the conditions of the reagents in the plurality of first networks can be clearly and definitely obtained, in the actual production, the ideal condition of the reagents stored in the first networks can be considered to be difficult to achieve, the first network closest to the final ideal condition in the actual condition can be obtained according to the searching of the second networks, parameters of the network are output to the detection node 01, and staff at the detection node 01 can correspondingly set according to the parameters so as to be close to the ideal condition and keep the uniformity of the conditions of the reagents in the plurality of first networks.
In a preferred embodiment of the present invention, the reagent quality whole process management system further comprises:
The plurality of detection center nodes 3, a third judgment rule is set in the detection center nodes 3, the third judgment rule sets a disqualification threshold corresponding to the reagents of different production batches, the detection center nodes 3 are respectively connected with the first-stage management node 1, disqualification instructions in all the first judgment results are received, all the disqualification instructions are judged according to the production batches,
When the number of the unqualified instructions exceeds the unqualified threshold, the detection center node 3 generates a stop instruction and sends the stop instruction to the first-stage management node 1 as a third judgment result;
the first level management node 1 will stop detecting the parameters of the reagent in the full life cycle of the corresponding reagent by the detection node 01 after receiving the stop instruction.
Specifically, the detecting center node 3 can determine according to the reject threshold, output the determination result, set the reject threshold to 3, when the detecting center node 3 detects all the first determination results of the same batch of reagents, and a reject instruction appears for 3 times, the detecting center node 3 generates a stop instruction and sends the stop instruction as a third determination result to the first-stage management node 1, and the batch of reagents can be regarded as severely reject reagents, so that the first-stage management node 1 stops detecting the reagents by the detecting node 01 after receiving the stop instruction, and accordingly, an operator corrects and replaces the reagents according to the third determination result.
In a preferred embodiment, the detection node 01, the first-stage management node 1, the second-stage management node 2 and the detection center node 3 construct a reagent quality overall process management system, so that problems in the process of reagent self-production, transmission and agent to detection can be timely detected, when the detection center node 3 analyzes and discovers that a plurality of reagents in different batches are abnormal according to the detection result of the detection node 01, the detection node 01 can be judged, and the second-stage management node 2 can analyze and discover according to different first-stage management nodes, so that quality problems of the reagents in the same batch can be obtained through express analysis.
The foregoing is merely illustrative of the preferred embodiments of the present invention and is not intended to limit the embodiments and scope of the present invention, and it should be appreciated by those skilled in the art that equivalent substitutions and obvious variations may be made using the description and illustrations of the present invention, and are intended to be included in the scope of the present invention.

Claims (8)

1. A reagent quality full-flow management system based on a blockchain technology, which is used for detecting the quality of a reagent and is characterized by comprising a plurality of detection nodes of different types, wherein the detection nodes are used for detecting parameters of the reagent in the full life cycle of the reagent, and each parameter is marked with a corresponding production batch of the reagent;
The reagent quality whole flow management system further comprises:
The first-stage management nodes are respectively integrated with part of the detection nodes to form a first network;
In each first network, the first-stage management node is configured to receive the parameters output by all the detection nodes and determine to obtain a first determination result, where the first-stage management node feeds back the first determination result to different detection nodes;
in each first network, each detection node is used for recording the parameters sent to the first-stage management node by all other detection nodes;
The second-level management node is integrated with all the first-level management nodes to form a second network;
In the second network, the second level management node is configured to receive all the first determination results and determine to obtain a second determination result, where the second level management node feeds back the second determination result to the first level management node, and the first level management node feeds back the second determination result to different detection nodes;
setting a first judgment rule in the first-stage management node, wherein the first judgment rule is used for setting a parameter threshold and a parameter deviation threshold corresponding to different types of parameters respectively, and the first-stage management node is used for calculating a deviation value between the parameters and the parameter threshold and judging the deviation value;
When the deviation value exceeds the parameter deviation threshold, the first-stage management node includes the deviation value in a disqualified instruction and sends the disqualified instruction as the first judgment result to the detection node corresponding to the parameter;
when the deviation value does not exceed the parameter deviation threshold value, the first-stage management node includes the deviation value in a qualified instruction and sends the deviation value to the detection node corresponding to the parameter as the first judgment result;
The second management node sets a second judgment rule, the second judgment rule sets deviation indexes corresponding to different types of deviation values respectively, the second management node calculates an index difference value between the deviation value and the deviation index according to the deviation value in the first judgment result, judges the index difference value to obtain the minimum index difference value, and includes the minimum index difference value and the parameter of the detection node corresponding to the index difference value in the second judgment result, and feeds back the minimum index difference value and the parameter of the detection node to different detection nodes through the first management node.
2. The reagent quality whole flow management system based on the blockchain technology according to claim 1, wherein the types of the parameters include:
The production parameters are used for recording parameters obtained by the detection node of the first node type in the process of detecting the reagent production of the reagent;
the transportation parameter is used for recording parameters obtained by the detection node of the second node type in the process of detecting the transportation reagent of the reagent as the production parameter;
the agent parameter is used for recording parameters obtained by the detection node of the third node type in the agent selling process of detecting the reagent;
and the detection parameters are used for recording parameters obtained by the detection node of the fourth node type in the laboratory detection process of detecting the reagent.
3. The blockchain technology-based reagent quality whole flow management system according to claim 1, wherein the production parameters comprise detection calibration ranges on the reagent design.
4. The blockchain technology-based reagent quality whole flow management system according to claim 1, wherein the transportation parameters include temperature, time and appearance breakage during transportation and storage of the reagent.
5. The blockchain technology-based reagent quality whole flow management system of claim 1, wherein the proxy parameters include proxy storage temperature, expiration date and appearance breakage of the reagent.
6. A reagent quality overall process management system based on a blockchain technique according to claim 3, wherein the detection parameter comprises an actual detection value of the reagent in an actual detection process.
7. The reagent quality whole flow management system based on the blockchain technology according to claim 1, wherein the types of the parameters further include:
And the standard substance parameters are used for recording parameters obtained by the detection node of the fifth node type in the process of detecting the standard substance, wherein the standard substance is one of the reagents for detection.
8. The reagent quality whole flow management system based on the blockchain technology of claim 1, wherein the reagent quality whole flow management system further comprises:
A plurality of detection center nodes, wherein a third judging rule is arranged in the detection center nodes, the third judging rule is provided with a disqualification threshold corresponding to reagents of different production batches, the detection center nodes are respectively connected with the first-stage management nodes, disqualification instructions in all the first judging results are received, all the disqualification instructions are judged according to the production batches,
When the number of the unqualified instructions exceeds the unqualified threshold, the detection center node generates a stop instruction and sends the stop instruction to a first-stage management node as a third judgment result;
The first level management node will stop the detection node from detecting the parameter of the reagent in the full life cycle of the corresponding reagent after receiving the stop instruction.
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