CN111772659B - Method for rat respiratory tract inhalation VSP lung imaging - Google Patents
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- A61B6/00—Apparatus for radiation diagnosis, e.g. combined with radiation therapy equipment
- A61B6/02—Devices for diagnosis sequentially in different planes; Stereoscopic radiation diagnosis
- A61B6/03—Computerised tomographs
- A61B6/032—Transmission computed tomography [CT]
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- A61B6/04—Positioning of patients; Tiltable beds or the like
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- A61B6/0421—Supports, e.g. tables or beds, for the body or parts of the body with immobilising means
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61B6/50—Clinical applications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61D—VETERINARY INSTRUMENTS, IMPLEMENTS, TOOLS, OR METHODS
- A61D3/00—Appliances for supporting or fettering animals for operative purposes
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- A—HUMAN NECESSITIES
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- A61D—VETERINARY INSTRUMENTS, IMPLEMENTS, TOOLS, OR METHODS
- A61D7/00—Devices or methods for introducing solid, liquid, or gaseous remedies or other materials into or onto the bodies of animals
- A61D7/04—Devices for anaesthetising animals by gases or vapours; Inhaling devices
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B2503/00—Evaluating a particular growth phase or type of persons or animals
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- A—HUMAN NECESSITIES
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- A61B2503/00—Evaluating a particular growth phase or type of persons or animals
- A61B2503/42—Evaluating a particular growth phase or type of persons or animals for laboratory research
Abstract
The invention discloses a method for rat respiratory tract inhalation VSP lung imaging. In the present invention, different VSPs 320 are configured to administer the agent: the first group is VSP320 solution with concentration of 0.1 ml/kg; the second group is VSP320 solution with concentration of 0.3 ml/kg; the third group is a VSP320 solution with a concentration of 0.5 ml/kg; the fourth group was a VSP320 solution at a concentration of 0.7ml/kg, and rats were allowed to nebulize inhaled drug: after the rat is fixed, fully and uniformly mixing the prepared corresponding solution, adding the solution into an atomizer, and completely atomizing the liquid within 5-10 min; and (4) continuing CT scanning: and recording the scanning data; experiments carried out by the method prove that the change of the CT value of lung tissues is enhanced along with the increase of the dose of VSP, and the effect of 0.7ml/kg dose is the best at present; the optimal imaging time of different dosages is different, and most of the optimal display time is 120min; therefore, the optimal condition of the rat respiratory tract when the rat respiratory tract is inhaled into the VSP lung for imaging is obtained, so that the information technology can be subsequently applied to the field of human medical imaging, and good news is brought to more patients.
Description
Technical Field
The invention belongs to the technical field of medical imaging, and particularly relates to a method for rat respiratory tract inhalation VSP lung imaging.
Background
Pulmonary imaging includes Pulmonary Perfusion imaging (pulmony Perfusion imaging), pulmonary Ventilation imaging (pulmony Ventilation imaging), and Pulmonary tumor imaging. Lung perfusion imaging shows the perfusion of the blood flow in lung tissue, and the common imaging agent is Tc-labeled megalin (Tc-MAA). After Tc-MAA37MBq (containing MAA 0.5mg, about 20-50 ten thousand particles with the diameter of 10-60 mu m) is injected into a vein once, the medicine can be uniformly and temporarily plugged into a pulmonary capillary bed, the number of locally plugged particles is in direct proportion to the blood perfusion amount, and because the plugged capillaries only account for one dozen ten thousand of the total number of the capillaries, the change of the cardiopulmonary hemodynamics and the pulmonary function can not be caused. Usually, the image is displayed immediately after injection, the images of the two lungs of a normal person are clear, the radioactivity distribution is basically uniform, the blood flow of the lung tip is low under the influence of gravity, and the radioactivity is relatively sparse. The lung ventilation image reflects the air filling condition of alveoli in each part of respiratory tract and whole lung.
However, the results of the common phenomena are fuzzy, which is not beneficial for doctors to observe the lungs of patients more carefully, thereby possibly delaying the timely treatment of the patients and delaying the illness state.
Disclosure of Invention
The invention aims to: in order to solve the problems proposed above, a method for pulmonary imaging of rat respiratory tract inhalation VSP is provided.
The technical scheme adopted by the invention is as follows: a method for rat respiratory tract inhalation VSP pulmonary imaging, which is characterized by comprising the following steps: the method for pulmonary imaging of rat respiratory tract inhalation VSP requires the following materials: VSP320 pharmaceutical one-part; one part of normal saline; a box of sodium pentobarbital injection; one atomizing device (for children); one CT scanner; 1ml syringe; 3ml syringe; one 100-microliter pipette; a first electronic balance; one fixing device is arranged.
In a preferred embodiment, the method for pulmonary imaging of rat respiratory inhalation VSP comprises the steps of:
s1: 10 SD rats are selected for the experiment, the rats are fasted for 12h before the experiment without water, the rats are randomly selected on the day of the experiment, an electronic balance frame is taken, each rat is weighed, and the experiment data are recorded;
s2: preparation of the test agents was started: this configuration process is accomplished by selecting different configurations of VSP320 dosing: the control group was completely saline; experimental group the first group was set to a VSP320 solution at a concentration of 0.1 ml/kg; the second group is VSP320 solution with concentration of 0.3 ml/kg; the third group is a VSP320 solution with a concentration of 0.5 ml/kg; the fourth group is VSP320 solution with concentration of 0.7 ml/kg;
s3: taking the rat in the step S1, preparing to perform anesthesia treatment on the rat, and injecting a sodium pentobarbital solution into the abdominal cavity of the rat during anesthesia, wherein the injection dose is 30mg/kg;
s4: until the rat is completely anesthetized in the step S3, switching on a power supply of the CT scanner, checking and setting various parameters of the CT scanner, and preparing to carry out the next step after the CT scanner is adjusted;
s5: taking a rat, respectively fixing four limbs of the rat on an operation table of a CT scanner to ensure that the rat cannot easily fall off, starting to scan the rat as a base line, and then recording scanning data;
s6: the rats were initially prepared for aerosol inhalation of the drug: fixing the anesthetized rat in the step S5 to enable the rat to be in a supine state, aligning the breathing mask to the head of the rat, and aligning the air outlet to the nose of the rat;
s7: after the rats are fixed, fully and uniformly mixing the corresponding solution prepared in the step S2, adding the mixture into an atomizer, and completely atomizing the liquid within 5-10min (the power of the atomizer cannot be adjusted);
s8: and (4) continuing CT scanning: after the aerosol inhalation is finished, respectively scanning the whole body of the rat by adopting a scanning scheme with the same scanning parameters after 0-180 min, and recording the scanning data:
s9: and (3) acquiring data, drawing a CT value-time curve of bilateral lung tissues by comparing CT values of the bilateral lung tissues at different time points, and analyzing the optimal administration dose and the optimal image acquisition time.
In a preferred embodiment, the weight of the rat selected in step S1 should be in the range of 90-100g, and the body condition of the rat should be kept healthy.
In a preferred embodiment, in step S3, the dose of the sodium pentobarbital solution is injected, the anesthesia time of the rat is about 90min, and the rat is recovered and then chased according to half of the above dose.
In a preferred embodiment, the scan parameters of the CT scanner in step S5 are: 80kv,50mas, pitch, 0.5, fov.
In a preferred embodiment, in step S9, after the test is finished, the fixing device, the CT scanner, and the atomizing device may be respectively sterilized and cleaned.
In summary, due to the adoption of the technical scheme, the invention has the beneficial effects that:
1. in the invention, the experiment carried out by the method proves that the rat aerosol inhalation VSP lung imaging method is feasible; meanwhile, with the increase of VSP dosage, the change of CT value of lung tissue is enhanced, and the current 0.7ml/kg dosage has the best effect; the optimal imaging time is different for different dosages, and the optimal display time is 120min for most of the imaging; therefore, the optimal condition for rat respiratory tract inhalation VSP lung imaging is obtained, and the information technology can be applied to the field of human medical imaging subsequently, thereby bringing good news for more patients.
Detailed Description
In order to make the objects, technical solutions and advantages of the embodiments of the present invention clearer, the technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the embodiments of the present invention, and it is obvious that the described embodiments are some embodiments of the present invention, but not all embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
Example one
A method for pulmonary imaging of rat respiratory tract inhalation VSP, which requires the use of the following materials: VSP320 pharmaceutical one-part; one part of normal saline; one box of the pentobarbital sodium injection; one atomizing device (for children); one CT scanner; 1ml syringe; a 3ml syringe; one 100-microliter pipettor; a first electronic balance; one fixing device is arranged.
The method for pulmonary imaging of rat respiratory tract inhalation VSP comprises the following steps:
s1: 10 SD rats are selected for the experiment, the rats are fasted for 12 hours before the experiment without water prohibition, the rats are randomly selected on the same day of the experiment, an electronic balance is taken, each rat is weighed, the experiment data is recorded, the weight range of the rats selected in the step S1 is between 90 g and 100g, and the body conditions of the rats are kept healthy;
s2: preparation of the test agents was started: this configuration process is accomplished by selecting different configurations of VSP320 dosing: the control group was completely saline; experimental groups the first group was set to a VSP320 solution at a concentration of 0.1 ml/kg; the second group is VSP320 solution with concentration of 0.3 ml/kg; the third group is a VSP320 solution with a concentration of 0.5 ml/kg; the fourth group is VSP320 solution with the concentration of 0.7 ml/kg;
s3: taking the rat in the step S1, preparing to perform anesthesia treatment, injecting a sodium pentobarbital solution into the abdominal cavity of the rat during anesthesia, wherein the injection dose is 30mg/kg, injecting the sodium pentobarbital solution under the injection dose in the step S3, enabling the rat to perform anesthesia for about 90min, and adding the sodium pentobarbital solution according to half of the dose after the rat is recovered;
s4: and (3) after the rat is completely anesthetized, switching on a power supply of the CT scanner, checking and setting various parameters of the CT scanner, adjusting the CT scanner and then preparing for the next step, wherein the scanning parameters of the CT scanner in the step (5) are as follows: 80kv,50mas, pitch, 0.5, fov;
s5: taking a rat, respectively fixing four limbs of the rat on an operation table of a CT scanner to ensure that the rat cannot easily fall off, starting to scan the rat as a base line, and then recording scanning data;
s6: the rats were initially prepared for aerosol inhalation of the drug: fixing the anesthetized rat in the step S5 to enable the rat to be in a supine state, aligning the breathing mask to the head of the rat, and aligning the air outlet to the nose of the rat;
s7: after the rats are fixed, fully and uniformly mixing the corresponding solution prepared in the step S2, adding the mixture into an atomizer, and completely atomizing the liquid within 5-10min (the power of the atomizer cannot be adjusted);
s8: and (4) continuing CT scanning: within 0min after the aerosol inhalation is finished, the rat is scanned systemically by adopting a scanning scheme with the same scanning parameters, and scanning data are recorded:
s9: data are collected, CT values of bilateral lung tissues at different time points are compared, CT value-time curves of the bilateral lung tissues are drawn, the optimal administration dose and the optimal image collection time are analyzed, and in the step S9, after the test is finished, the fixing device, the CT scanner and the atomization device can be disinfected and cleaned respectively.
Example two:
a method for pulmonary imaging of rat respiratory tract inhalation VSP, which requires the use of the following materials: VSP320 pharmaceutical one portion; one part of normal saline; a box of sodium pentobarbital injection; one atomizing device (for children); one CT scanner; 1ml syringe; a 3ml syringe; one 100-microliter pipettor; a first electronic balance; one fixing device is arranged.
The method for pulmonary imaging of rat respiratory tract inhalation VSP comprises the following steps:
s1: 10 SD rats are selected for the experiment, the rats are fasted for 12h before the experiment without water, the rats are randomly selected on the day of the experiment, an electronic balance frame is taken, each rat is weighed, the experiment data is recorded, the weight range of the rats selected in the step S1 is 90-100g, and the body conditions of the rats are kept healthy;
s2: preparation of the test agents was started: this configuration process is accomplished by selecting different configurations of VSP320 dosing: the control group was completely saline; experimental group the first group was set to a VSP320 solution at a concentration of 0.1 ml/kg; the second group is VSP320 solution with concentration of 0.3 ml/kg; the third group is a VSP320 solution with a concentration of 0.5 ml/kg; the fourth group is VSP320 solution with the concentration of 0.7 ml/kg;
s3: taking the rat in the step S1, preparing to perform anesthesia treatment, injecting a sodium pentobarbital solution into the abdominal cavity of the rat during anesthesia, wherein the injection dose is 30mg/kg, injecting the sodium pentobarbital solution under the injection dose in the step S3, enabling the rat to perform anesthesia for about 90min, and adding the sodium pentobarbital solution according to half of the dose after the rat is recovered;
s4: and (4) in the step S3, after the rat is completely anesthetized, switching on the power supply of the CT scanner, checking and setting various parameters of the CT scanner, adjusting the CT scanner and preparing for the next step, wherein the scanning parameters of the CT scanner in the step S5 are as follows: 80kv,50mas, pitch, 0.5, fov;
s5: taking a rat, respectively fixing four limbs of the rat on an operation table of a CT scanner to prevent the rat from falling off easily, starting to scan the rat as a baseline, and then recording scanning data;
s6: the rats were initially prepared for aerosol inhalation of the drug: fixing the anesthetized rat in the step S5 to enable the rat to be in a supine state, aligning the breathing mask to the head of the rat, and aligning the air outlet to the nose of the rat;
s7: after the rat is fixed, fully and uniformly mixing the corresponding solution prepared in the step S2, adding the mixture into an atomizer, and completely atomizing the liquid within 5-10min (the power of the atomizer cannot be adjusted);
s8: and (4) continuing CT scanning: after 30min, 60min and 90min after the aerosol inhalation is finished, the rat is scanned systemically by adopting a scanning scheme with the same scanning parameters, and scanning data are recorded:
s9: data are collected, CT values of bilateral lung tissues at different time points are compared, CT value-time curves of the bilateral lung tissues are drawn, the optimal administration dosage and the optimal image collection time are analyzed, and in the step S9, after the experiment is finished, the fixing device, the CT scanner and the atomization device can be respectively disinfected and cleaned.
EXAMPLE III
A method for pulmonary imaging of rat respiratory tract inhalation VSP, which requires the use of the following materials: VSP320 pharmaceutical one-part; one part of normal saline; a box of sodium pentobarbital injection; one atomizing device (for children); one CT scanner; 1ml syringe; 3ml syringe; one 100-microliter pipette; a first electronic balance; one fixing device is arranged.
The method for pulmonary imaging of rat respiratory tract inhalation VSP comprises the following steps:
s1: 10 SD rats are selected for the experiment, the rats are fasted for 12 hours before the experiment without water prohibition, the rats are randomly selected on the same day of the experiment, an electronic balance is taken, each rat is weighed, the experiment data is recorded, the weight range of the rats selected in the step S1 is between 90 g and 100g, and the body conditions of the rats are kept healthy;
s2: preparation of the test agents was started: this configuration process is accomplished by selecting different configurations of VSP320 dosing: the control group was completely saline; experimental group the first group was set to a VSP320 solution at a concentration of 0.1 ml/kg; the second group is VSP320 solution with concentration of 0.3 ml/kg; the third group is a VSP320 solution with a concentration of 0.5 ml/kg; the fourth group is VSP320 solution with the concentration of 0.7 ml/kg;
s3: taking the rat in the step S1, preparing to perform anesthesia treatment, injecting a sodium pentobarbital solution into the abdominal cavity of the rat during anesthesia, wherein the injection dose is 30mg/kg, injecting the sodium pentobarbital solution under the injection dose in the step S3, wherein the anesthesia time of the rat is about 90min, and adding the rat according to half of the dose after the rat is awakened;
s4: and (3) after the rat is completely anesthetized, switching on a power supply of the CT scanner, checking and setting various parameters of the CT scanner, adjusting the CT scanner and then preparing for the next step, wherein the scanning parameters of the CT scanner in the step (5) are as follows: 80kv,50mas, pitch, 0.5, fov;
s5: taking a rat, respectively fixing four limbs of the rat on an operation table of a CT scanner to ensure that the rat cannot easily fall off, starting to scan the rat as a base line, and then recording scanning data;
s6: the rats were initially prepared for aerosol inhalation of the drug: fixing the anesthetized rat in the step S5 to enable the rat to be in a supine state, aligning the breathing mask to the head of the rat, and aligning the air outlet to the nose of the rat;
s7: after the rat is fixed, fully and uniformly mixing the corresponding solution prepared in the step S2, adding the mixture into an atomizer, and completely atomizing the liquid within 5-10min (the power of the atomizer cannot be adjusted);
s8: and (4) continuing CT scanning: after 120min, 150min and 180min after the aerosol inhalation is finished, the rats are scanned systemically by adopting a scanning scheme with the same scanning parameters, and scanning data are recorded:
s9: data are collected, CT values of bilateral lung tissues at different time points are compared, CT value-time curves of the bilateral lung tissues are drawn, the optimal administration dosage and the optimal image collection time are analyzed, and in the step S9, after the experiment is finished, the fixing device, the CT scanner and the atomization device can be respectively disinfected and cleaned.
It is noted that, herein, relational terms such as first and second, and the like may be used solely to distinguish one entity or action from another entity or action without necessarily requiring or implying any actual such relationship or order between such entities or actions. Moreover, the terms "comprises," "comprising," or 014, and any other variations thereof, are intended to cover a non-exclusive inclusion, such that a process, method, article, or apparatus that comprises a list of elements does not include only those elements but may include other elements not expressly listed or inherent to such process, method, article, or apparatus. Without further limitation, an element defined by the phrases "comprising a," "8230," "8230," or "comprising" does not exclude the presence of additional like elements in a process, method, article, or apparatus that comprises the element.
The above examples are only intended to illustrate the technical solution of the present invention, but not to limit it; although the present invention has been described in detail with reference to the foregoing embodiments, it will be understood by those of ordinary skill in the art that: the technical solutions described in the foregoing embodiments may still be modified, or some technical features may be equivalently replaced; and such modifications or substitutions do not depart from the spirit and scope of the corresponding technical solutions of the embodiments of the present invention.
Claims (5)
1. A method for rat respiratory tract inhalation VSP pulmonary imaging, which is characterized by comprising the following steps: the method for pulmonary imaging of rat respiratory tract inhalation VSP requires the following materials: VSP320 pharmaceutical one portion; one part of normal saline; a box of sodium pentobarbital injection; one atomizing device; one CT scanner; 1ml syringe; a 3ml syringe; one 100-microliter pipette; a first electronic balance; one fixing device;
the method for pulmonary imaging of rat respiratory tract inhalation VSP comprises the following steps:
s1: 10 SD rats are selected for the experiment, the rats are fasted for 12h before the experiment without water, the rats are randomly selected on the day of the experiment, an electronic balance frame is taken, each rat is weighed, and the experiment data are recorded;
s2: preparation of the test agents was started: this configuration process is accomplished by selecting different configurations of VSP320 dosing: the control group completely adopts normal saline; experimental groups the first group was set to a VSP320 solution at a concentration of 0.1 ml/kg; the second group is VSP320 solution with concentration of 0.3 ml/kg; the third group is a VSP320 solution with a concentration of 0.5 ml/kg; the fourth group is VSP320 solution with the concentration of 0.7 ml/kg;
s3: taking the rat in the step S1, preparing to perform anesthesia treatment on the rat, and injecting a sodium pentobarbital solution into the abdominal cavity of the rat during anesthesia, wherein the injection dose is 30mg/kg;
s4: until the rat is completely anesthetized in the step S3, switching on a power supply of the CT scanner, checking and setting various parameters of the CT scanner, and preparing to carry out the next step after the CT scanner is adjusted;
s5: taking a rat, respectively fixing four limbs of the rat on an operation table of a CT scanner to prevent the rat from falling off easily, starting to scan the rat as a baseline, and then recording scanning data;
s6: the rats were initially prepared for aerosol inhalation of the drug: fixing the anesthetized rat in the step S5 to enable the rat to be in a supine state, aligning the breathing mask to the head of the rat, and aligning the air outlet to the nose of the rat;
s7: after the rat is well fixed, fully and uniformly mixing the corresponding solution prepared in the step S2, adding the mixture into an atomizer, and completely atomizing the liquid within 5-10 min;
s8: and (4) continuing CT scanning: after the aerosol inhalation is finished, respectively after 120min, 150min and 180min, the rat is scanned systemically by adopting a scanning scheme with the same scanning parameters, and scanning data are recorded:
s9: and (3) acquiring data, drawing a CT value-time curve of bilateral lung tissues by comparing CT values of the bilateral lung tissues at different time points, and analyzing the optimal administration dose and the optimal image acquisition time.
2. The method of claim 1 for pulmonary imaging of rat respiratory inhalation VSP, wherein: the weight of the rat selected in step S1 should be in the range of 90-100g, and the body condition of the rat should be kept healthy.
3. The method of claim 1 for pulmonary imaging of rat respiratory inhalation VSP, wherein: in step S3, the pentobarbital sodium solution at the dose is injected, the anesthesia time of the rat is about 90min, and the rat is added according to a half of the dose after awakening.
4. The method of claim 1 for pulmonary imaging of rat respiratory inhalation VSP comprising: the scanning parameters of the CT scanner in step S5 are: 80kv,50mas, pitch, 0.5, fov.
5. The method of claim 1 for pulmonary imaging of rat respiratory inhalation VSP comprising: in step S9, after the test is finished, the fixing device, the CT scanner, and the atomizing device may be sterilized and cleaned, respectively.
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