CN111772659A - Method for rat respiratory tract inhalation VSP lung imaging - Google Patents
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- A61B6/00—Apparatus for radiation diagnosis, e.g. combined with radiation therapy equipment
- A61B6/02—Devices for diagnosis sequentially in different planes; Stereoscopic radiation diagnosis
- A61B6/03—Computerised tomographs
- A61B6/032—Transmission computed tomography [CT]
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- A61B6/00—Apparatus for radiation diagnosis, e.g. combined with radiation therapy equipment
- A61B6/04—Positioning of patients; Tiltable beds or the like
- A61B6/0407—Supports, e.g. tables or beds, for the body or parts of the body
- A61B6/0421—Supports, e.g. tables or beds, for the body or parts of the body with immobilising means
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61D—VETERINARY INSTRUMENTS, IMPLEMENTS, TOOLS, OR METHODS
- A61D3/00—Appliances for supporting or fettering animals for operative purposes
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- A—HUMAN NECESSITIES
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- A61D—VETERINARY INSTRUMENTS, IMPLEMENTS, TOOLS, OR METHODS
- A61D7/00—Devices or methods for introducing solid, liquid, or gaseous remedies or other materials into or onto the bodies of animals
- A61D7/04—Devices for anaesthetising animals by gases or vapours; Inhaling devices
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B2503/00—Evaluating a particular growth phase or type of persons or animals
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B2503/00—Evaluating a particular growth phase or type of persons or animals
- A61B2503/42—Evaluating a particular growth phase or type of persons or animals for laboratory research
Abstract
The invention discloses a method for rat respiratory tract inhalation VSP lung imaging. In the present invention, different VSPs 320 are configured to administer the agent: the first group is VSP320 solution with concentration of 0.1 ml/kg; the second group is VSP320 solution with concentration of 0.3 ml/kg; the third group is a VSP320 solution with a concentration of 0.5 ml/kg; the fourth group was a VSP320 solution at a concentration of 0.7ml/kg, and rats were allowed to nebulize inhaled drug: after the rats are fixed, fully and uniformly mixing the prepared corresponding solution, adding the solution into an atomizer, and completely atomizing the liquid within 5-10 min; continuing to scan the CT: and recording the scanning structure and data; experiments carried out by the method prove that the change of the CT value of the lung tissue is enhanced along with the increase of the dosage of the VSP, and the effect of the current dosage of 0.7ml/kg is the best; the optimal imaging time is different for different dosages, and the optimal display time is 120min for most of the imaging; therefore, the optimal condition of the rat respiratory tract when the rat respiratory tract is inhaled into the VSP lung for imaging is obtained, so that the information technology can be subsequently applied to the field of human medical imaging, and good news is brought to more patients.
Description
Technical Field
The invention belongs to the technical field of medical imaging, and particularly relates to a method for rat respiratory tract inhalation VSP lung imaging.
Background
Pulmonary imaging includes Pulmonary Perfusion imaging (pulmony Perfusion imaging), Pulmonary Ventilation imaging (pulmony Ventilation imaging), and Pulmonary tumor imaging. Lung perfusion imaging shows the perfusion of the blood flow in lung tissue, and the common imaging agent is Tc-labeled megalin (Tc-MAA). After Tc-MAA37MBq (containing MAA0.5mg, about 20-50 ten thousand particles with the diameter of 10-60 mu m) is injected into a vein once, the medicine can be uniformly and temporarily plugged into a pulmonary capillary bed, the number of locally plugged particles is in direct proportion to the blood flow perfusion amount, and because the plugged capillary is only one dozen ten-thousandth of the total number of the capillary, the change of the cardio-pulmonary hemodynamics and the pulmonary function can not be caused. Usually, the image is displayed immediately after injection, the images of the two lungs of a normal person are clear, the radioactivity distribution is basically uniform, the blood flow of the lung tip is low under the influence of gravity, and the radioactivity is relatively sparse. The lung ventilation image reflects the air filling condition of alveoli in each part of respiratory tract and whole lung.
However, the results of the common phenomena are fuzzy, which is not beneficial for doctors to observe the lungs of patients more carefully, thereby possibly delaying the timely treatment of the patients and delaying the illness state.
Disclosure of Invention
The invention aims to: in order to solve the problems proposed above, a method for pulmonary imaging of rat respiratory tract inhalation VSP is provided.
The technical scheme adopted by the invention is as follows: a method for rat respiratory tract inhalation VSP pulmonary imaging, which is characterized by comprising the following steps: the method for pulmonary imaging of rat respiratory tract inhalation VSP requires the following materials: VSP320 pharmaceutical one portion; one part of normal saline; a box of sodium pentobarbital injection; one atomizing device (for children); one CT scanning device; 1ml syringe; a 3ml syringe; 100 μ l pipette for one day; a first electronic balance; one fixing device is arranged.
In a preferred embodiment, the method for pulmonary imaging of rat respiratory inhalation VSP comprises the steps of:
s1: 10 SD rats are selected for the experiment, and the rats are fasted for 12 hours before the experiment without water supply. Randomly selecting rats on the same day of the experiment, taking the rats to an electronic balance, weighing each rat, and recording test data;
s2: preparation of the test agents was started: this configuration process is accomplished by selecting different configurations of VSP320 dosing: the control group was completely saline; experimental groups the first group was set to a VSP320 solution at a concentration of 0.1 ml/kg; the second group is VSP320 solution with concentration of 0.3 ml/kg; the third group is a VSP320 solution with a concentration of 0.5 ml/kg; the fourth group is VSP320 solution with the concentration of 0.7 ml/kg;
s3: taking the rat in the step S1, preparing to perform anesthesia treatment, and injecting a sodium pentobarbital solution into the abdominal cavity of the rat during anesthesia, wherein the injection dose is 30 mg/kg;
s4: when the rats are completely anesthetized in step S3, a rat CT scan is started: taking the CT scanner, switching on the power supply of the scanner, checking and setting various parameters of the scanner, and adjusting the scanning device to prepare for the next step;
s5: taking a rat, respectively fixing four limbs of the rat on an operation table of a scanning device, so that the rat cannot easily fall off, starting scanning along with the rat to serve as baseline, and then recording scanning data;
s6: the rats were initially prepared for aerosol inhalation of the drug: fixing the anesthetized rat in the step S5 to enable the rat to be in a supine state, aligning the breathing mask with the head of the rat, and aligning the air outlet with the nose of the rat;
s7: after the rats are fixed, fully and uniformly mixing the corresponding solution prepared in the step S2, adding the mixture into an atomizer, and completely atomizing the liquid within 5-10min (the power of the atomizer cannot be adjusted);
s8: continuing to scan the CT: after the aerosol inhalation is finished, respectively after 0-180 min, scanning the whole body of the rat by adopting the scanning scheme with the same scanning parameters, and recording a scanning structure and data:
s9: and (3) acquiring data, drawing a CT value-time curve of bilateral lung tissues by comparing CT values of the bilateral lung tissues at different time points, and analyzing the optimal administration dose and the optimal image acquisition time.
In a preferred embodiment, the weight range of the rat selected in step S1 should be between 90-100g, and the body condition of the rat should be kept healthy.
In a preferred embodiment, in step S3, the dose of the sodium pentobarbital solution is injected, the anesthesia time of the rat is about 90min, and the rat is recovered and then chased according to half of the above dose.
In a preferred embodiment, the scanning parameters of the scanning device in step S5 are: 80kv,50mAs, Pith:0.5, FOV: 100.
In a preferred embodiment, in step S9, after the test is finished, the fixture, the CT scanner, and the atomizer may be respectively sterilized and cleaned.
In summary, due to the adoption of the technical scheme, the invention has the beneficial effects that:
1. in the invention, experiments carried out by the method prove that the rat aerosol inhalation VSP lung imaging method is feasible; meanwhile, the change of the CT value of the lung tissue is enhanced along with the increase of the dosage of the VSP, and the effect of the current dosage of 0.7ml/kg is the best; the optimal imaging time is different for different dosages, and the optimal display time is 120min for most of the imaging; therefore, the optimal condition for rat respiratory tract inhalation VSP lung imaging is obtained, so that the follow-up information technology can be applied to the field of human medical imaging, and good news is brought to more patients.
Detailed Description
In order to make the objects, technical solutions and advantages of the embodiments of the present invention clearer, the technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the embodiments of the present invention, and it is obvious that the described embodiments are some embodiments of the present invention, but not all embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
Example one
A method for pulmonary imaging of rat respiratory tract inhalation VSP, which requires the use of the following materials: VSP320 pharmaceutical one portion; one part of normal saline; a box of sodium pentobarbital injection; one atomizing device (for children); one CT scanning device; 1ml syringe; a 3ml syringe; 100 μ l pipette for one day; a first electronic balance; one fixing device is arranged.
The method for pulmonary imaging of rat respiratory tract inhalation VSP comprises the following steps:
s1: 10 SD rats are selected for the experiment, and the rats are fasted for 12 hours before the experiment without water supply. Randomly selecting rats on the same day of the experiment, taking the rats from an electronic balance, weighing each rat respectively, and recording test data, wherein the weight range of the rats selected in the step S1 is 90-100g, and the body conditions of the rats are kept healthy;
s2: preparation of the test agents was started: this configuration process is accomplished by selecting different configurations of VSP320 dosing: the control group was completely saline; experimental groups the first group was set to a VSP320 solution at a concentration of 0.1 ml/kg; the second group is VSP320 solution with concentration of 0.3 ml/kg; the third group is a VSP320 solution with a concentration of 0.5 ml/kg; the fourth group is VSP320 solution with the concentration of 0.7 ml/kg;
s3: taking the rat in the step S1, preparing to perform anesthesia treatment, injecting a sodium pentobarbital solution into the abdominal cavity of the rat during anesthesia, wherein the injection dose is 30mg/kg, in the step S3, injecting the sodium pentobarbital solution under the injection dose, the anesthesia time of the rat is about 90min, and the rat is added according to half of the dose after awakening;
s4: when the rats are completely anesthetized in step S3, a rat CT scan is started: at this time, the CT scanner is taken, the power of the scanner is turned on, various parameters of the scanner are checked and set, and the scanner is adjusted to be ready for the next step, where the scanning parameters of the scanner in step S5 are: 80kv,50mAs, Pith:0.5, FOV: 100;
s5: taking a rat, respectively fixing four limbs of the rat on an operation table of a scanning device, so that the rat cannot easily fall off, starting scanning along with the rat to serve as baseline, and then recording scanning data;
s6: the rats were initially prepared for aerosol inhalation of the drug: fixing the anesthetized rat in the step S5 to enable the rat to be in a supine state, aligning the breathing mask with the head of the rat, and aligning the air outlet with the nose of the rat;
s7: after the rats are fixed, fully and uniformly mixing the corresponding solution prepared in the step S2, adding the mixture into an atomizer, and completely atomizing the liquid within 5-10min (the power of the atomizer cannot be adjusted);
s8: continuing to scan the CT: and (3) scanning the whole body of the rat by adopting a scanning scheme with the same scanning parameters within 0min after the aerosol inhalation is finished, and recording a scanning structure and data:
s9: data are collected, CT values of bilateral lung tissues at different time points are compared, CT value-time curves of the bilateral lung tissues are drawn, the optimal administration dosage and the optimal image collection time are analyzed, and in step S9, after the experiment is finished, the fixing device, the CT scanning device and the atomizing device can be respectively disinfected and cleaned.
Example two:
a method for pulmonary imaging of rat respiratory tract inhalation VSP, which requires the use of the following materials: VSP320 pharmaceutical one portion; one part of normal saline; a box of sodium pentobarbital injection; one atomizing device (for children); one CT scanning device; 1ml syringe; a 3ml syringe; 100 μ l pipette for one day; a first electronic balance; one fixing device is arranged.
The method for pulmonary imaging of rat respiratory tract inhalation VSP comprises the following steps:
s1: 10 SD rats are selected for the experiment, and the rats are fasted for 12 hours before the experiment without water supply. Randomly selecting rats on the same day of the experiment, taking the rats from an electronic balance, weighing each rat respectively, and recording test data, wherein the weight range of the rats selected in the step S1 is 90-100g, and the body conditions of the rats are kept healthy;
s2: preparation of the test agents was started: this configuration process is accomplished by selecting different configurations of VSP320 dosing: the control group was completely saline; experimental groups the first group was set to a VSP320 solution at a concentration of 0.1 ml/kg; the second group is VSP320 solution with concentration of 0.3 ml/kg; the third group is a VSP320 solution with a concentration of 0.5 ml/kg; the fourth group is VSP320 solution with the concentration of 0.7 ml/kg;
s3: taking the rat in the step S1, preparing to perform anesthesia treatment, injecting a sodium pentobarbital solution into the abdominal cavity of the rat during anesthesia, wherein the injection dose is 30mg/kg, in the step S3, injecting the sodium pentobarbital solution under the injection dose, the anesthesia time of the rat is about 90min, and the rat is added according to half of the dose after awakening;
s4: when the rats are completely anesthetized in step S3, a rat CT scan is started: at this time, the CT scanner is taken, the power of the scanner is turned on, various parameters of the scanner are checked and set, and the scanner is adjusted to be ready for the next step, where the scanning parameters of the scanner in step S5 are: 80kv,50mAs, Pith:0.5, FOV: 100;
s5: taking a rat, respectively fixing four limbs of the rat on an operation table of a scanning device, so that the rat cannot easily fall off, starting scanning along with the rat to serve as baseline, and then recording scanning data;
s6: the rats were initially prepared for aerosol inhalation of the drug: fixing the anesthetized rat in the step S5 to enable the rat to be in a supine state, aligning the breathing mask with the head of the rat, and aligning the air outlet with the nose of the rat;
s7: after the rats are fixed, fully and uniformly mixing the corresponding solution prepared in the step S2, adding the mixture into an atomizer, and completely atomizing the liquid within 5-10min (the power of the atomizer cannot be adjusted);
s8: continuing to scan the CT: after the aerosol inhalation is finished for 30min, 60min and 90min, scanning the whole body of the rat by adopting a scanning scheme with the same scanning parameters, and recording a scanning structure and data:
s9: data are collected, CT values of bilateral lung tissues at different time points are compared, CT value-time curves of the bilateral lung tissues are drawn, the optimal administration dosage and the optimal image collection time are analyzed, and in step S9, after the experiment is finished, the fixing device, the CT scanning device and the atomizing device can be respectively disinfected and cleaned.
EXAMPLE III
A method for pulmonary imaging of rat respiratory tract inhalation VSP, which requires the use of the following materials: VSP320 pharmaceutical one portion; one part of normal saline; a box of sodium pentobarbital injection; one atomizing device (for children); one CT scanning device; 1ml syringe; a 3ml syringe; 100 μ l pipette for one day; a first electronic balance; one fixing device is arranged.
The method for pulmonary imaging of rat respiratory tract inhalation VSP comprises the following steps:
s1: 10 SD rats are selected for the experiment, and the rats are fasted for 12 hours before the experiment without water supply. Randomly selecting rats on the same day of the experiment, taking the rats from an electronic balance, weighing each rat respectively, and recording test data, wherein the weight range of the rats selected in the step S1 is 90-100g, and the body conditions of the rats are kept healthy;
s2: preparation of the test agents was started: this configuration process is accomplished by selecting different configurations of VSP320 dosing: the control group was completely saline; experimental groups the first group was set to a VSP320 solution at a concentration of 0.1 ml/kg; the second group is VSP320 solution with concentration of 0.3 ml/kg; the third group is a VSP320 solution with a concentration of 0.5 ml/kg; the fourth group is VSP320 solution with the concentration of 0.7 ml/kg;
s3: taking the rat in the step S1, preparing to perform anesthesia treatment, injecting a sodium pentobarbital solution into the abdominal cavity of the rat during anesthesia, wherein the injection dose is 30mg/kg, in the step S3, injecting the sodium pentobarbital solution under the injection dose, the anesthesia time of the rat is about 90min, and the rat is added according to half of the dose after awakening;
s4: when the rats are completely anesthetized in step S3, a rat CT scan is started: at this time, the CT scanner is taken, the power of the scanner is turned on, various parameters of the scanner are checked and set, and the scanner is adjusted to be ready for the next step, where the scanning parameters of the scanner in step S5 are: 80kv,50mAs, Pith:0.5, FOV: 100;
s5: taking a rat, respectively fixing four limbs of the rat on an operation table of a scanning device, so that the rat cannot easily fall off, starting scanning along with the rat to serve as baseline, and then recording scanning data;
s6: the rats were initially prepared for aerosol inhalation of the drug: fixing the anesthetized rat in the step S5 to enable the rat to be in a supine state, aligning the breathing mask with the head of the rat, and aligning the air outlet with the nose of the rat;
s7: after the rats are fixed, fully and uniformly mixing the corresponding solution prepared in the step S2, adding the mixture into an atomizer, and completely atomizing the liquid within 5-10min (the power of the atomizer cannot be adjusted);
s8: continuing to scan the CT: after 120min, 150min and 180min after the aerosol inhalation is finished, scanning the whole body of the rat by adopting a scanning scheme with the same scanning parameters, and recording a scanning structure and data:
s9: data are collected, CT values of bilateral lung tissues at different time points are compared, CT value-time curves of the bilateral lung tissues are drawn, the optimal administration dosage and the optimal image collection time are analyzed, and in step S9, after the experiment is finished, the fixing device, the CT scanning device and the atomizing device can be respectively disinfected and cleaned.
It is noted that, herein, relational terms such as first and second, and the like may be used solely to distinguish one entity or action from another entity or action without necessarily requiring or implying any actual such relationship or order between such entities or actions. Moreover, the terms "comprises," "comprising," or 014, and any other variations thereof, are intended to cover a non-exclusive inclusion, such that a process, method, article, or apparatus that comprises a list of elements does not include only those elements but may include other elements not expressly listed or inherent to such process, method, article, or apparatus. Without further limitation, an element defined by the phrase "comprising an … …" does not exclude the presence of other identical elements in a process, method, article, or apparatus that comprises the element.
The above examples are only intended to illustrate the technical solution of the present invention, but not to limit it; although the present invention has been described in detail with reference to the foregoing embodiments, it will be understood by those of ordinary skill in the art that: the technical solutions described in the foregoing embodiments may still be modified, or some technical features may be equivalently replaced; and such modifications or substitutions do not depart from the spirit and scope of the corresponding technical solutions of the embodiments of the present invention.
Claims (6)
1. A method for rat respiratory tract inhalation VSP pulmonary imaging, which is characterized by comprising the following steps: the method for pulmonary imaging of rat respiratory tract inhalation VSP requires the following materials: VSP320 pharmaceutical one portion; one part of normal saline; a box of sodium pentobarbital injection; one atomizing device (for children); one CT scanning device; 1ml syringe; a 3ml syringe; 100 μ l pipette for one day; a first electronic balance; one fixing device is arranged.
2. The method of claim 1 for pulmonary imaging of rat respiratory inhalation VSP, wherein: the method for pulmonary imaging of rat respiratory tract inhalation VSP comprises the following steps:
s1: 10 SD rats are selected for the experiment, and the rats are fasted for 12 hours before the experiment without water supply. Randomly selecting rats on the same day of the experiment, taking the rats to an electronic balance, weighing each rat, and recording test data;
s2: preparation of the test agents was started: this configuration process is accomplished by selecting different configurations of VSP320 dosing: the control group was completely saline; experimental groups the first group was set to a VSP320 solution at a concentration of 0.1 ml/kg; the second group is VSP320 solution with concentration of 0.3 ml/kg; the third group is a VSP320 solution with a concentration of 0.5 ml/kg; the fourth group is VSP320 solution with the concentration of 0.7 ml/kg;
s3: taking the rat in the step S1, preparing to perform anesthesia treatment, and injecting a sodium pentobarbital solution into the abdominal cavity of the rat during anesthesia, wherein the injection dose is 30 mg/kg;
s4: when the rats are completely anesthetized in step S3, a rat CT scan is started: taking the CT scanner, switching on the power supply of the scanner, checking and setting various parameters of the scanner, and adjusting the scanning device to prepare for the next step;
s5: taking a rat, respectively fixing four limbs of the rat on an operation table of a scanning device, so that the rat cannot easily fall off, starting scanning along with the rat to serve as baseline, and then recording scanning data;
s6: the rats were initially prepared for aerosol inhalation of the drug: fixing the anesthetized rat in the step S5 to enable the rat to be in a supine state, aligning the breathing mask with the head of the rat, and aligning the air outlet with the nose of the rat;
s7: after the rats are fixed, fully and uniformly mixing the corresponding solution prepared in the step S2, adding the mixture into an atomizer, and completely atomizing the liquid within 5-10min (the power of the atomizer cannot be adjusted);
s8: continuing to scan the CT: after the aerosol inhalation is finished, respectively after 0-180 min, scanning the whole body of the rat by adopting the scanning scheme with the same scanning parameters, and recording a scanning structure and data:
s9: and (3) acquiring data, drawing a CT value-time curve of bilateral lung tissues by comparing CT values of the bilateral lung tissues at different time points, and analyzing the optimal administration dose and the optimal image acquisition time.
3. The method of claim 1 for pulmonary imaging of rat respiratory inhalation VSP, wherein: the weight range of the rat selected in step S1 should be between 90-100g, and the body condition of the rat should be kept healthy.
4. The method of claim 1 for pulmonary imaging of rat respiratory inhalation VSP, wherein: in step S3, the pentobarbital sodium solution is injected at the dose, the anesthesia time of the rat is about 90min, and the rat is added at half of the dose after awakening.
5. The method of claim 1 for pulmonary imaging of rat respiratory inhalation VSP, wherein: the scanning parameters of the scanning device in step S5 are: 80kv,50mAs, Pith:0.5, FOV: 100.
6. The method of claim 1 for pulmonary imaging of rat respiratory inhalation VSP, wherein: in step S9, after the test is finished, the fixing device, the CT scanner, and the atomizing device may be sterilized and cleaned respectively.
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WO2011035140A1 (en) * | 2009-09-18 | 2011-03-24 | Paka Pulmonary Pharmaceuticals, Inc. | Methods and compositions for delivery of contrast moieties to the lungs |
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