CN111729122A - Corn protein composite medical dressing and preparation method and application thereof - Google Patents
Corn protein composite medical dressing and preparation method and application thereof Download PDFInfo
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- CN111729122A CN111729122A CN202010545352.0A CN202010545352A CN111729122A CN 111729122 A CN111729122 A CN 111729122A CN 202010545352 A CN202010545352 A CN 202010545352A CN 111729122 A CN111729122 A CN 111729122A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
- A61L15/225—Mixtures of macromolecular compounds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
- A61L15/32—Proteins, polypeptides; Degradation products or derivatives thereof, e.g. albumin, collagen, fibrin, gelatin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
- A61L15/44—Medicaments
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
- A61L2300/252—Polypeptides, proteins, e.g. glycoproteins, lipoproteins, cytokines
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/418—Agents promoting blood coagulation, blood-clotting agents, embolising agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/60—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
- A61L2300/602—Type of release, e.g. controlled, sustained, slow
- A61L2300/604—Biodegradation
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Abstract
The invention relates to a corn protein composite medical dressing and a preparation method and application thereof. The zein composite medical dressing is a film mainly composed of zein (2-98% by mass), polyacrylic acid (2-98% by mass) and polyvinylpyrrolidone (0-96% by mass). The water absorption capacity is 2-80 times of the dry weight of the film, and the stretching ratio is 1-5 times of the original film length. The preparation method comprises the following steps: respectively dissolving zein and polyacrylic acid in a mixed solution of ethanol and water, wherein the volume percentage concentration of the ethanol is 55-95%, mixing the zein and the water, and standing and drying at a constant temperature of 20-50 ℃ or freeze-drying; then adding a mixed solution of ethanol and water of polyvinylpyrrolidone, wherein the volume percentage concentration of the ethanol is 55-95%; standing and drying at a constant temperature of 20-50 ℃ or freeze drying to form a film, thus obtaining the corn protein composite medical dressing. The zein composite medical dressing can be used for wound hemostasis and tissue repair.
Description
Technical Field
The invention belongs to the technical field of medical wound dressings, and particularly relates to a corn protein composite medical dressing as well as a preparation method and application thereof.
Background
After the body is injured to form a wound, professional treatment is needed, and infection, non-healing and scar formation can be caused by improper treatment. The ideal wound dressing not only can stop bleeding, but also can effectively promote the repair and regeneration of damaged tissues.
The existing wound dressings are various in types and have advantages and disadvantages. The traditional dressing (such as gauze made of natural or synthetic fiber) has low price, can quickly absorb blood and wound exudate, and has simple processing process. But the permeability is too high, so that the wound surface is easy to dehydrate; and because microorganisms cannot be isolated, cross infection is easy to cause; in addition, the wound dressing is easy to adhere to the wound surface and is difficult to remove. The novel dressing (such as carrageenan, alginate, chitosan, collagen and composite materials thereof) comprises a film shape, a foam shape, hydrogel, colloid and the like, has excellent blood and exudate absorption capacity, can prevent cross infection caused by microorganism invasion, but has poor flexibility which is the biggest defect of the dressings.
Disclosure of Invention
The invention aims to provide a corn protein composite medical dressing and a preparation method and application thereof.
The purpose of the invention can be realized by the following technical scheme:
the invention provides a corn protein composite medical dressing which comprises the following components in percentage by mass: 2-98% of zein, 2-98% of polyacrylic acid and 0-96% of polyvinylpyrrolidone.
In one embodiment of the invention, the zein composite medical dressing comprises the following components in percentage by mass: 5-80% of zein, 20-95% of polyacrylic acid and 0-75% of polyvinylpyrrolidone.
In one embodiment, the zein composite medical dressing comprises the following components in percentage by mass: 35-65% of zein, 35-65% of polyacrylic acid and 0-30% of polyvinylpyrrolidone.
In the invention, the zein composite medical dressing is a film.
The water absorption capacity of the zein composite medical dressing is 2-80 times of the self dry mass, and the stretching ratio is 1-5 times of the length of the original film.
The invention also provides a preparation method of the corn protein composite medical dressing, when the corn protein composite medical dressing does not contain polyvinylpyrrolidone, the zein and the polyacrylic acid are respectively dissolved in mixed solution of ethanol and water, and after the zein and the polyacrylic acid are mixed, the zein and the water are subjected to constant-temperature standing drying or freeze drying to form a film, so that the corn protein composite medical dressing is prepared.
The invention also provides a preparation method of the corn protein composite medical dressing, when the corn protein composite medical dressing contains polyvinylpyrrolidone, the zein and the polyacrylic acid are respectively dissolved in a mixed solution of ethanol and water, and after the zein and the polyacrylic acid are mixed, the zein and the polyacrylic acid are subjected to constant-temperature standing drying or freeze drying; and then adding a mixed solution of ethanol containing polyvinylpyrrolidone and water, and standing and drying at constant temperature or freeze-drying to form a film to prepare the corn protein composite medical dressing.
In one embodiment of the invention, the volume percentage concentration of ethanol in the mixed solution of ethanol and water is 55-95%.
In one embodiment of the invention, the constant temperature standing temperature is 20-50 ℃.
The invention also provides application of the corn protein composite medical dressing and application of the corn protein composite medical dressing in wounds. The zein composite medical dressing can be used for wound hemostasis and tissue repair.
The invention also provides medical equipment containing the corn protein composite medical dressing.
In the invention, the zein has the characteristics of excellent biocompatibility, degradability, absorbability, easy film formation and the like, and particularly, the zein film has strength and flexibility and is a main factor for endowing the zein composite medical dressing with tensile property. Polyacrylic acid has strong adhesion, high water absorption capacity as same as polyvinylpyrrolidone, and good water retention, and is a safe medical material which is clinically applied. The water absorption of the polyacrylic acid enables the film to combine with more water molecules, and the flexibility of the film is further improved. Based on the characteristics of the materials, the corn protein composite medical dressing with excellent mechanical property, high water absorption and adhesion and good hemostatic effect is prepared. In addition to the hydrophilic component and the addition ratio, the microstructure of the membrane is also affected by the drying process, which results in a porous network-like structure.
Compared with the prior art, the invention has the advantages that:
1. the zein composite medical dressing provided by the invention has excellent tensile property, adhesion and water absorption, has high matching property with moving parts such as joints, can be tightly attached even if a wound part deforms, can effectively absorb blood moisture and wound exudate, can keep a wound surface dry while playing a hemostatic function, is not easy to infect, and is beneficial to tissue repair. In addition, the membrane can be completely removed with physiological saline or the like after functioning.
2. The zein composite medical dressing provided by the invention is simple in preparation method and mild in condition; the used solvents are water and ethanol, so that the environment is friendly; does not need subsequent complicated purification steps, and is beneficial to mass production. Has wide application prospect.
Drawings
FIG. 1: a schematic view (a) and a photograph (B) of the zein composite medical dressing prepared in example 2 after water absorption.
FIG. 2: scanning electron microscope photo of the surface of the zein composite medical dressing prepared in example 3.
FIG. 3: the pictures of the zein composite medical dressing prepared in example 4 before stretching (A), after stretching (B) in water, and the tensile strength curve (C).
FIG. 4: the zein composite medical dressing prepared in example 7 is used for photos of burn before repair (A) and after repair (B).
FIG. 5: photographs of the zein composite medical dressing prepared in example 9 on rat liver bleeding hemostasis (a) and after hemostasis and removal (B).
FIG. 6: photograph of the zein composite medical dressing prepared in example 10 attached to the finger joint (a) and repeatedly bent 5 times (B).
Detailed Description
The invention is described in detail below with reference to the figures and specific embodiments.
Example 1
The corn protein composite medical dressing is prepared from the following raw materials in parts by mass: 10g of zein and 0.2g of polyacrylic acid.
The preparation method of the zein composite medical dressing comprises the following steps:
dissolving zein and polyacrylic acid in 100mL of mixed solution of ethanol and water respectively, wherein the volume percentage concentration of the ethanol is 55%. After mixing, the mixture is kept still and dried at the constant temperature of 20 ℃. The corn protein composite medical dressing material is prepared.
Example 2
The corn protein composite medical dressing is prepared from the following raw materials in parts by mass: 0.2g of zein and 10g of polyacrylic acid.
The preparation method of the zein composite medical dressing comprises the following steps:
dissolving zein and polyacrylic acid in 100mL of mixed solution of ethanol and water respectively, wherein the volume percentage concentration of the ethanol is 55%. After mixing, standing and drying at the constant temperature of 20 ℃ to prepare the corn protein composite medical dressing material.
When the zein composite medical dressing prepared in this example is subjected to a water absorption test, the zein composite medical dressing prepared in this example has a water absorption capacity of 5 times of the self dry mass, and a stretching ratio of 2 times of the original film length.
Fig. 1 is a photograph of a corn protein composite medical dressing material (a) and a photograph of the dressing material (B) after water absorption, which were prepared in this example.
Example 3
The corn protein composite medical dressing is prepared from the following raw materials in parts by mass: 1g of zein, 1g of polyacrylic acid and 0.1g of polyvinylpyrrolidone.
The preparation method of the zein composite medical dressing comprises the following steps:
dissolving zein and polyacrylic acid in 100mL of mixed solution of ethanol and water respectively, wherein the volume percentage concentration of the ethanol is 55%. Mixing, and freeze drying. Then, 100mL of a mixed solution of ethanol and water containing polyvinylpyrrolidone was added, and the volume percentage concentration of ethanol was 55%. Freeze drying to form film to obtain the composite medical corn protein dressing material.
The zein composite medical dressing prepared by the embodiment has the water absorption capacity of 2 times of the self dry mass, and the stretching ratio of 5 times of the length of the original film.
Fig. 2 is a scanning electron microscope photograph of the surface of the zein composite medical dressing prepared by the embodiment. As can be seen from figure 2, the zein composite medical dressing obtained by freeze drying is of a reticular porous structure.
Example 4
The corn protein composite medical dressing is prepared from the following raw materials in parts by mass: 2g of zein, 2g of polyacrylic acid and 1g of polyvinylpyrrolidone.
The preparation method of the zein composite medical dressing comprises the following steps:
dissolving zein and polyacrylic acid in 100mL of mixed solution of ethanol and water respectively, wherein the volume percentage concentration of the ethanol is 55%. Mixing, standing at constant temperature of 20 ℃, and drying. Then, the mixture was added to 100mL of a mixed solution of ethanol and water containing polyvinylpyrrolidone, wherein the volume percentage concentration of ethanol was 55%. Standing at a constant temperature of 20 ℃ and drying to form a film, thus obtaining the corn protein composite medical dressing material.
The zein composite medical dressing prepared by the embodiment has the water absorption capacity of 80 times of the self dry mass, and the stretching ratio of 1 time of the original film length.
Fig. 3 is a picture of a zein composite medical dressing object prepared by the embodiment before stretching (a) and after stretching (B) in water, and a tensile strength curve (C).
Example 5
The corn protein composite medical dressing is prepared from the following raw materials in parts by mass: 0.1g of zein, 0.1g of polyacrylic acid and 4.8g of polyvinylpyrrolidone.
The preparation method of the zein composite medical dressing comprises the following steps:
dissolving zein and polyacrylic acid in 100mL of mixed solution of ethanol and water respectively, wherein the volume percentage concentration of the ethanol is 65%. Mixing, standing at constant temperature of 25 ℃, and drying. Then adding the mixture into 100mL of mixed solution of ethanol and water containing polyvinylpyrrolidone, wherein the volume percentage concentration of the ethanol is 65%. Standing at a constant temperature of 25 ℃, drying and forming a film to prepare the corn protein composite medical dressing material.
Example 6
The corn protein composite medical dressing is prepared from the following raw materials in parts by mass: 5g of zein, 2.5g of polyacrylic acid and 5g of polyvinylpyrrolidone.
The preparation method of the zein composite medical dressing comprises the following steps:
dissolving zein and polyacrylic acid in 100mL of mixed solution of ethanol and water respectively, wherein the volume percentage concentration of the ethanol is 65%. After mixing, the mixture is kept still and dried at the constant temperature of 25 ℃. Then, 100mL of a mixed solution of ethanol and water containing polyvinylpyrrolidone was added, and the volume percentage concentration of ethanol was 65%. Standing at a constant temperature of 25 ℃, drying and forming a film to prepare the corn protein composite medical dressing material.
Example 7
The corn protein composite medical dressing is prepared from the following raw materials in parts by mass: 1.5g of zein and 1g of polyacrylic acid.
The preparation method of the zein composite medical dressing comprises the following steps:
dissolving zein and polyacrylic acid in 100mL of mixed solution of ethanol and water respectively, wherein the volume percentage concentration of the ethanol is 65%. And standing at a constant temperature of 25 ℃ after mixing, drying and forming a film to prepare the corn protein composite medical dressing material.
Fig. 4 is photographs of a composite medical dressing prepared in this example before (a) and after (B) repairing a burned skin of a rat. It can be seen from the figure that the wound scab had fallen off and the skin tissue was completely repaired.
Example 8
The corn protein composite medical dressing is prepared from the following raw materials in parts by mass: 25g of zein, 1g of polyacrylic acid and 2g of polyvinylpyrrolidone.
The preparation method of the zein composite medical dressing comprises the following steps:
dissolving zein and polyacrylic acid in 100mL of mixed solution of ethanol and water respectively, wherein the volume percentage concentration of the ethanol is 75%. Mixing, standing at constant temperature of 30 ℃ and drying. Then adding the mixture into 100mL of mixed solution of ethanol and water containing polyvinylpyrrolidone, wherein the volume percentage concentration of the ethanol is 75%. Standing at a constant temperature of 30 ℃ and drying to form a film, thus obtaining the corn protein composite medical dressing material.
Example 9
The corn protein composite medical dressing is prepared from the following raw materials in parts by mass: 1g of zein, 5g of polyacrylic acid and 10g of polyvinylpyrrolidone.
The preparation method of the zein composite medical dressing comprises the following steps:
dissolving zein and polyacrylic acid in 100mL of mixed solution of ethanol and water respectively, wherein the volume percentage concentration of the ethanol is 75%. Mixing, and freeze drying. Then adding the mixture into 100mL of mixed solution of ethanol and water containing polyvinylpyrrolidone, wherein the volume percentage concentration of the ethanol is 75%. Freeze drying to form film to obtain the composite medical corn protein dressing material.
Fig. 5 is a photograph of rat liver bleeding hemostasis (a), hemostasis and removal (B) using the zein composite medical dressing prepared in this example.
As can be seen from the figure, the wound material was completely removed after hemostasis without further bleeding.
Example 10
The corn protein composite medical dressing is prepared from the following raw materials in parts by mass: 40g of zein, 2.5g of polyacrylic acid and 5g of polyvinylpyrrolidone.
The preparation method of the zein composite medical dressing comprises the following steps:
dissolving zein and polyacrylic acid in 100mL of mixed solution of ethanol and water respectively, wherein the volume percentage concentration of the ethanol is 85%. Mixing, standing at constant temperature of 40 ℃, and drying. Then adding the mixture into 100mL of mixed solution of ethanol and water containing polyvinylpyrrolidone, wherein the volume percentage concentration of the ethanol is 85%. Standing at a constant temperature of 40 ℃ and drying to form a film, thus obtaining the corn protein composite medical dressing material.
Fig. 6 is a photograph of the zein composite medical dressing prepared by this example, which is attached to a finger joint (a) and repeatedly bent 5 times (B).
The graph shows that the zein composite medical dressing prepared by the embodiment has good adhesion and deformability.
Example 11
The corn protein composite medical dressing is prepared from the following raw materials in parts by weight: 30g of zein, 5g of polyacrylic acid and 5g of polyvinylpyrrolidone.
The preparation method of the zein composite medical dressing comprises the following steps:
dissolving zein and polyacrylic acid in 100mL of mixed solution of ethanol and water respectively, wherein the volume percentage concentration of the ethanol is 95%. Mixing, standing at 50 deg.C, and drying. Then adding the mixture into 100mL of mixed solution of ethanol and water containing polyvinylpyrrolidone, wherein the volume percentage concentration of the ethanol is 95%. Standing at a constant temperature of 50 ℃ and drying to form a film, thus obtaining the corn protein composite medical dressing material.
Example 12
The corn protein composite medical dressing is prepared from the following raw materials in parts by mass: 50g of zein, 10g of polyacrylic acid and 10g of polyvinylpyrrolidone.
The preparation method of the zein composite medical dressing comprises the following steps:
dissolving zein and polyacrylic acid in 100mL of mixed solution of ethanol and water respectively, wherein the volume percentage concentration of the ethanol is 95%. After mixing, the mixture is kept still and dried at the constant temperature of 50 ℃. Then, 100mL of a mixed solution of ethanol and water containing polyvinylpyrrolidone was added, and the volume percentage concentration of ethanol was 95%. Standing at a constant temperature of 50 ℃, drying and forming a film to obtain the corn protein composite medical dressing material.
In the components of the corn protein composite medical dressing, zein plays a main role in maintaining the strength of the film, but the water absorption capacity is limited due to the hydrophobicity of the zein, and the water absorption performance is greatly improved by adding hydrophilic polyacrylic acid and polyvinylpyrrolidone; wherein the addition of polyvinylpyrrolidone (PVP) resulted in a significant increase in the water absorption capacity and facilitated the formation of a network (fig. 2); polyacrylic acid contributes to the adhesion and has a synergistic effect on the improvement of the tensile properties (table 1).
Table 1 breaking strength and elongation of zein composite medical dressing films.
The embodiments described above are intended to facilitate the understanding and use of the invention by those skilled in the art. It will be readily apparent to those skilled in the art that various modifications to these embodiments may be made, and the generic principles described herein may be applied to other embodiments without the use of the inventive faculty. Therefore, the present invention is not limited to the above embodiments, and those skilled in the art should make improvements and modifications within the scope of the present invention based on the disclosure of the present invention.
Claims (10)
1. The corn protein composite medical dressing is characterized by comprising the following components in percentage by mass: 2-98% of zein, 2-98% of polyacrylic acid and 0-96% of polyvinylpyrrolidone.
2. The zein composite medical dressing as claimed in claim 1, wherein the zein composite medical dressing comprises the following components in percentage by mass: 5-80% of zein, 20-95% of polyacrylic acid and 0-75% of polyvinylpyrrolidone.
3. The zein composite medical dressing as claimed in claim 2, wherein the zein composite medical dressing comprises the following components in percentage by mass: 35-65% of zein, 35-65% of polyacrylic acid and 0-30% of polyvinylpyrrolidone.
4. The zein composite medical dressing of claim 1, 2 or 3 wherein said zein composite medical dressing is a film.
5. The zein composite medical dressing of claim 4, wherein said film has a water absorption of 2-80 times the dry weight of the film and a stretch ratio of 1-5 times the original film length.
6. The method for preparing the zein composite medical dressing as claimed in claim 1, 2 or 3, wherein the zein and the polyacrylic acid are respectively dissolved in a mixed solution of ethanol and water, and after the zein and the polyacrylic acid are mixed, the zein composite medical dressing is prepared by standing at a constant temperature for drying or freeze drying to form a film.
7. The preparation method of the zein composite medical dressing as claimed in claim 6, wherein the zein and the polyacrylic acid are respectively dissolved in a mixed solution of ethanol and water, and after the zein and the polyacrylic acid are mixed, the zein and the polyacrylic acid are subjected to standing drying at a constant temperature or freeze drying; and then adding a mixed solution of ethanol containing polyvinylpyrrolidone and water, standing at a constant temperature for drying or freeze drying, and forming a film to obtain the corn protein composite medical dressing.
8. The preparation method of the zein composite medical dressing as claimed in claim 6 or 7, wherein in the mixed solution of ethanol and water, the volume percentage concentration of ethanol is 55-95%.
9. The preparation method of the zein composite medical dressing as claimed in claim 6 or 7, wherein the constant temperature standing temperature is 20-50 ℃.
10. A medical device comprising the zein composite medical dressing of claim 1 or 2 or 3.
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| CN202010545352.0A CN111729122A (en) | 2020-06-16 | 2020-06-16 | Corn protein composite medical dressing and preparation method and application thereof |
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| CN202010545352.0A CN111729122A (en) | 2020-06-16 | 2020-06-16 | Corn protein composite medical dressing and preparation method and application thereof |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112826978A (en) * | 2021-02-04 | 2021-05-25 | 苏州康德诺生物科技有限公司 | Novel dressing and preparation method thereof |
| CN113069587A (en) * | 2021-03-31 | 2021-07-06 | 江南大学 | Moisture-permeable, hemostatic and antibacterial wound dressing and preparation method thereof |
| IT202200010895A1 (en) * | 2022-05-25 | 2023-11-25 | Fondazione St Italiano Tecnologia | BIOCOMPATIBLE AND BIODEGRADABLE COMPOSITE MATERIAL FOR THE UNDERWATER RELEASE OF ACTIVE AGENTS AND RELATED USES |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101541314A (en) * | 2006-06-14 | 2009-09-23 | 爱若涂层制品有限公司 | Device for delivering active ingredients to humans, animals and plants |
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2020
- 2020-06-16 CN CN202010545352.0A patent/CN111729122A/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101541314A (en) * | 2006-06-14 | 2009-09-23 | 爱若涂层制品有限公司 | Device for delivering active ingredients to humans, animals and plants |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112826978A (en) * | 2021-02-04 | 2021-05-25 | 苏州康德诺生物科技有限公司 | Novel dressing and preparation method thereof |
| CN113069587A (en) * | 2021-03-31 | 2021-07-06 | 江南大学 | Moisture-permeable, hemostatic and antibacterial wound dressing and preparation method thereof |
| CN113069587B (en) * | 2021-03-31 | 2022-04-29 | 江南大学 | Moisture-permeable, hemostatic and antibacterial wound dressing and preparation method thereof |
| IT202200010895A1 (en) * | 2022-05-25 | 2023-11-25 | Fondazione St Italiano Tecnologia | BIOCOMPATIBLE AND BIODEGRADABLE COMPOSITE MATERIAL FOR THE UNDERWATER RELEASE OF ACTIVE AGENTS AND RELATED USES |
| EP4282921A1 (en) * | 2022-05-25 | 2023-11-29 | Fondazione Istituto Italiano di Tecnologia | Biocompatible and biodegradable composite material for underwater delivery active agents and uses thereof |
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