CN1116919C - Small area hollow fibre membrane plasma separation filter - Google Patents
Small area hollow fibre membrane plasma separation filter Download PDFInfo
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- CN1116919C CN1116919C CN98111939A CN98111939A CN1116919C CN 1116919 C CN1116919 C CN 1116919C CN 98111939 A CN98111939 A CN 98111939A CN 98111939 A CN98111939 A CN 98111939A CN 1116919 C CN1116919 C CN 1116919C
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- membrane
- blood
- plasma separation
- separation filter
- plasma
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- External Artificial Organs (AREA)
Abstract
The present invention relates to a hollow fibre membrane blood plasma separating filter with a small area. The present invention is characterized in that hollow fibre membranes are fixed in a cylinder body by pouring sealant. The cylinder body is sealed by a sealing ring. An upper end cover and a lower end cover are respectively screwed. A blood inlet is arranged on the upper end cover, and a concentrated blood cell outlet is arranged on the lower end cover. A blood plasma outlet is arranged on the cylinder body. The length of a separator is from 200 to 270mm, and the diameter of the separator is from 20 to 36mm. The effective length of the hollow fibre membranes is from 150 to 200mm, and the number of the hollow fibre membranes is from 500 to 1000. The inner diameter of fibre is from 350(+/-)40 um, and the thickness of membranous walls is 60(+/-)20 um. The hole diameter of the membranes is from 0.2 to 0.8 um, and the effective area of the membranes is from 0.06 to 0.15m<2>. The present invention has the advantages of small area, low cost, high separation efficiency of blood plasma, and continuous blood plasma collection and realizes automation.
Description
The present invention relates to a kind of small size doughnut membrane plasma separation filter, particularly, hollow-fibre membrane is made the small size plasma separation filter, be used for for taking the blood plasma field.
Plasma separation has two kinds of centrifugal and membrane types, separate at U.S.'s centrifugal plasma and occupy than big market, and membrane type blood plasma is separated in Japan and is widely used; Membrane Plasma Separator has flat sheet membrane and two kinds of forms of hollow-fibre membrane again.
Plasma separation be recent two decades grow up be used for separated plasma, or treat the new and high technology of some ticklish blood and immunity disease clinically.When blood plasma is taked in special use, all adopt the discontinuous centrifugal separation technology at present, after will taking out for slurry person's blood, go out blood plasma through centrifugation, remaining haemocyte then feeds back to supplying slurry person.1988, U.S. Baxter company combined centrifugal and two kinds of isolation technics of membrane type, has released the centrifugal novel machine-collected plasma method of polyamide flat sheet membrane under the shearing force effect, but less (the about 0.0064m of the area of its flat sheet membrane
2), shear rate is very big, therefore is prone to haemolysis.1985, people such as Gupta (B.B.Gupta et al, Artificial Organs, 10 (1): 45-51,1985) had the research report of small size doughnut membrane plasma separation filter.The inferior Thailand in domestic Ningbo also produces the doughnut membrane plasma separator, but all is used for clinically, and then cost is too high for taking blood plasma, does not specialize in the doughnut membrane plasma separation filter product appearance of taking blood plasma use so still have so far both at home and abroad.
The objective of the invention is to provide a kind of small size doughnut membrane plasma separation filter of continuous, suitable collection blood plasma at the deficiencies in the prior art.Be characterized in hollow-fibre membrane is fixed in the cylindrical shell of certain size with casting glue, it is less and plasma separation efficient is higher specializes in and gather the doughnut membrane plasma separation filter that blood plasma is used to be made into area.
Purpose of the present invention is realized by following technical measures:
Small size doughnut membrane plasma separation filter is with hollow-fibre membrane (1), be fixed in the cylindrical shell (3) with casting glue (2), sealing ring (4) sealing, tighten end cap (5) (6) up and down respectively, upper end cover is provided with blood inlet (7), and bottom end cover is provided with deshydremia cell outlet (8), and the simplified blood plasma that is provided with exports (9), separator length is 200～270mm, and diameter is 20～36mm.
The material of hollow-fibre membrane is polyether sulfone, modified poly (ether-sulfone), polysulfones, polymethyl methacrylate, polyacrylonitrile, polypropylene or polyamide, the hollow-fibre membrane effective length is 150～200mm, radical is 500～1000, fibre inner diameter is 350 ± 40um, thick 60 ± the 20um of membranous wall, membrane aperture is 0.2～0.8um, the effective area 0.06～0.15m of film
2
The material of small size doughnut membrane plasma separation filter is metal, plastics, rubber and/or other nonmetallic materials.
The manufacture method of small size doughnut membrane plasma separation filter: with the hollow-fibre membrane (1) of certain-length, earlier with the pre-end-blocking of casting glue, adopt centrifugal process to encapsulate then with casting glue (2), and be fixed in the cylindrical shell (3), cut the hollow-fibre membrane redundance, with sealing ring (4) sealing, tighten end cap (5) (6).
Small size doughnut membrane plasma separation filter is used for for taking blood plasma, and the blood inlet meets blood supply person by pipeline and peristaltic pump, and the deshydremia cell feeds back to blood supply person, and blood plasma is taked by the blood plasma outlet.The inlet blood flow is 80～150ml/min, and plasma separation filter port of export pressure is 0～25mmHg, and plasmaflux is 20～35ml/min.
The present invention has following advantage:
1. this small size doughnut membrane plasma separation filter can supply to take blood plasma usefulness continuously, and can realize automation;
2. the size of separator and effective film area are all little, and cost reduces, but the separative efficiency height;
3. the present invention adopts the technology path of oneself, and making can have been filled up domestic blank for taking blood plasma with small size doughnut membrane plasma separation filter.
Concrete structure of the present invention is provided by the following drawings and embodiment:
Fig. 1 is the structural representation of small size doughnut membrane plasma separation filter, (1) hollow-fibre membrane wherein, (2) casting glue, (3) cylindrical shell, (4) sealing ring, (5) upper end cover, (6) bottom end cover, (7) blood inlet, (8) deshydremia cell outlet, the outlet of (9) blood plasma.
Embodiment
Below by embodiment the present invention is specifically described; be necessary to be pointed out that at this following examples only are used for the present invention is further specified; can not be interpreted as limiting the scope of the invention, the person skilled in art can make some nonessential improvement and adjustment to the present invention according to foregoing.
1. small size doughnut membrane plasma separation filter is with polyether sulfone hollow-fibre membrane (1), be fixed in the Merlon cylindrical shell (3) with polyurethane pouring sealant (2), seal with silicon rubber loop (4), tighten end cap (5) (6) up and down respectively, upper end cover is provided with blood inlet (7), and bottom end cover is provided with dense volume haemocyte outlet (8), and the Merlon cylindrical shell is provided with blood plasma outlet (9), separator is long to be 250mm, and diameter is 30mm.Polyether sulfone hollow-fibre membrane internal diameter 350um, membrane aperture 0.4um, fiber effective length 180mm, 510 of radicals, filter effective area 0.1m
2, inlet blood flow 100ml/min, during outlet pressure 5mmHg, plasmaflux is 30ml/min.
2. in the identical structure of embodiment 1, with the modified poly (ether-sulfone) hollow-fibre membrane, internal diameter 360um, membrane aperture 0.4um, fiber effective length 180mm, 400 of radicals, filter effective area 0.08m
2, be fixed in the Merlon cylindrical shell with polyurethane pouring sealant.The separator of making, at inlet blood flow 100ml/min, during outlet pressure 5mmHg, plasmaflux is 25ml/min.
3. in the identical structure of embodiment 1, with the polyamide hollow-fibre membrane, internal diameter 330um, membrane aperture 0.65um, fiber effective length 180mm, 550 of radicals, filter effective area 0.1m
2, be fixed in the Merlon cylindrical shell with polyurethane pouring sealant.The separator of making, at inlet blood flow 100ml/min, during outlet pressure 5mmHg, plasmaflux is 32ml/min.
Claims (5)
1. small size doughnut membrane plasma separation filter, it is characterized in that this separating filter is with hollow-fibre membrane (1), be fixed in the cylindrical shell (3) with casting glue (2), end cap (5) (6) is up and down tightened in sealing ring (4) sealing respectively, and upper end cover is provided with blood inlet (7), bottom end cover is provided with deshydremia cell outlet (8), cylindrical shell is provided with blood plasma outlet (9), and separator length is 200～270mm, and diameter is 20～36mm.
2. according to the described small size doughnut of claim 1 membrane plasma separation filter, it is characterized in that the doughnut membrane material that this separating filter is used is polyether sulfone, modified poly (ether-sulfone), polysulfones, polymethyl methacrylate, polyacrylonitrile, polypropylene or polyamide, the hollow-fibre membrane effective length is 150～200mm, radical is 500～1000, fibre inner diameter is 350 ± 40um, thick 60 ± the 20um of membranous wall, membrane aperture is 0.2～0.8um, the effective area 0.06～0.15m of film
2
3. according to claim 1 or 2 described small size doughnut membrane plasma separation filters, the material that it is characterized in that this separator is metal, plastics, rubber and/or other nonmetallic materials.
4. according to the manufacture method of the described small size doughnut of claim 1 membrane plasma separation filter, it is characterized in that this separating filter is the hollow-fibre membrane (1) with certain-length, earlier with the pre-end-blocking of casting glue, adopt centrifugal process to encapsulate then with casting glue (2), and be fixed in the cylindrical shell (3), cut the hollow-fibre membrane redundance,, tighten end cap (5) (6) with sealing ring (4) sealing.
5. the purposes of the described small size doughnut of claim 1 membrane plasma separation filter, it is characterized in that this separating filter is used for for taking blood plasma, the blood inlet meets blood supply person by pipeline and peristaltic pump, the deshydremia cell feeds back to blood supply person, blood plasma is taked by the blood plasma outlet, at the inlet blood flow is 80～150ml/min, and plasma separation filter port of export pressure is 0～25mmHg, and plasmaflux is 20～35ml/min.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN98111939A CN1116919C (en) | 1998-04-07 | 1998-04-07 | Small area hollow fibre membrane plasma separation filter |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN98111939A CN1116919C (en) | 1998-04-07 | 1998-04-07 | Small area hollow fibre membrane plasma separation filter |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1231212A CN1231212A (en) | 1999-10-13 |
| CN1116919C true CN1116919C (en) | 2003-08-06 |
Family
ID=5221823
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN98111939A Expired - Fee Related CN1116919C (en) | 1998-04-07 | 1998-04-07 | Small area hollow fibre membrane plasma separation filter |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1116919C (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10639618B2 (en) | 2017-12-29 | 2020-05-05 | China Petroleum & Chemical Corporation | Wax oil hydrocracking method and system |
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|---|---|---|---|---|
| CA2455669A1 (en) | 2003-02-04 | 2004-08-04 | Bayer Healthcare, Llc | Method and test strip for determining glucose in blood |
| JP3890066B2 (en) * | 2005-06-27 | 2007-03-07 | 積水化学工業株式会社 | Blood separation instrument and blood separation device |
| US9603356B2 (en) | 2011-10-24 | 2017-03-28 | Kaneka Corporation | Method for producing cell concentrate |
| CN102512955A (en) * | 2011-11-03 | 2012-06-27 | 深圳市普特生物医学工程有限公司 | Blood separating column |
| WO2014034456A1 (en) | 2012-08-30 | 2014-03-06 | 株式会社カネカ | Method for producing cell concentrate |
| CN103725599B (en) * | 2014-01-14 | 2015-05-27 | 刘韬 | Fluid film filter cell separation device |
| TWI571276B (en) * | 2014-12-26 | 2017-02-21 | 國立高雄大學 | Blood isolation and extraction method and device thereof |
| CN106139285B (en) * | 2016-07-29 | 2018-07-06 | 武汉仝干医疗科技股份有限公司 | Four-in-one lint wire type bioartificial liver monitors on-line and heated at constant temperature integrated system |
| CN106139289B (en) * | 2016-07-29 | 2018-06-19 | 武汉仝干医疗科技股份有限公司 | Semi-permeable membrane is layered integrated biological reactor |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS60247163A (en) * | 1984-05-22 | 1985-12-06 | Toyobo Co Ltd | Serum separator for examination |
| US4619639A (en) * | 1980-02-05 | 1986-10-28 | Asahi Medical Co., Ltd. | Method and apparatus for low pressure filtration of plasma from blood |
| US5286449A (en) * | 1988-04-04 | 1994-02-15 | Asahi Medical Co., Ltd. | Adsorber module for whole blood treatment and an adsorber apparatus containing the adsorber module |
-
1998
- 1998-04-07 CN CN98111939A patent/CN1116919C/en not_active Expired - Fee Related
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4619639A (en) * | 1980-02-05 | 1986-10-28 | Asahi Medical Co., Ltd. | Method and apparatus for low pressure filtration of plasma from blood |
| JPS60247163A (en) * | 1984-05-22 | 1985-12-06 | Toyobo Co Ltd | Serum separator for examination |
| US5286449A (en) * | 1988-04-04 | 1994-02-15 | Asahi Medical Co., Ltd. | Adsorber module for whole blood treatment and an adsorber apparatus containing the adsorber module |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10639618B2 (en) | 2017-12-29 | 2020-05-05 | China Petroleum & Chemical Corporation | Wax oil hydrocracking method and system |
Also Published As
| Publication number | Publication date |
|---|---|
| CN1231212A (en) | 1999-10-13 |
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