CN111690947A - Electrochemical synthesis method of trifluoromethylated aryl amide derivative - Google Patents
Electrochemical synthesis method of trifluoromethylated aryl amide derivative Download PDFInfo
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- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/81—Amides; Imides
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- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/38—Nitrogen atoms
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- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Abstract
An electrochemical synthesis method of trifluoromethylated aryl amide derivatives comprises the following steps: adding a substrate aryl amide, a trifluoromethyl reagent, an electrolyte and a solvent into a reaction container with an electrode, stirring and reacting the reaction mixture at a constant current of 5-20mA for 30-180min at 25-75 ℃, and then carrying out post-treatment on the reaction solution to obtain a product trifluoromethyl aryl amide derivative; the structural formula of the substrate aryl amide is shown as a formula (Ia) or a formula (Ib), and correspondingly, the structural formula of the obtained product trifluoromethyl aryl amide derivative is shown as a formula (IIa) or a formula (IIb); the method is green, friendly, simple, convenient and efficient; substrate:
the product is as follows:
Description
Technical Field
The invention relates to an electrochemical synthesis method of trifluoromethylated aryl amide derivatives, belonging to the field of organic synthesis.
Background
Trifluoromethyl has a significant effect on the properties of the compound such as lipophilicity, permeability, metabolic stability and the like. Therefore, the efficient introduction of trifluoromethyl into pharmaceutical and agrochemical products, as well as functional organic materials, has become an important research area in the chemical field. Trifluoromethyl is also present in many drugs and is a key structure for the construction of drugs and active intermediates, for example, the drug Demigran (flumetidone acetate) for migraine, the anti-aids drug Efavirenz (Efavirenz), the drug Celebrex (celecoxib) for arthritis, the drug Januvia (sitagliptin) for type II diabetes, the antiviral drug triflurodine (trofluvudine), and the like all contain a trifluoromethyl group. In addition, trifluoromethylated aromatics play a key role in many important organic compounds. There is no doubt that new methods for introducing trifluoromethyl groups into different molecular structures rapidly, efficiently and with high selectivity are receiving increasing attention.
In modern organic synthesis, C-H functionalization is widely concerned by organic chemists because of the characteristics of no need of pre-functionalization of substrates, high atomic effect and the like. Therefore, the direct trifluoromethylation by using the method becomes an effective synthetic method. Zhang et al reported the pyridine amide to target anilines and CF3SO2Na as a raw material, K2S2O8Is an oxidant, Ni (OAc)2·6H2O is a catalyst in H2Reacting in O to obtain an aniline ortho-position trifluoromethylation product; xia et al reported photocatalytic C-H bond trifluoromethylation of aromatic amines with picolinamide directed to anilines and CF3SO2Na is used as a raw material, ferrocene is used as a catalyst, acetone is used as a solvent, and the reaction is carried out at room temperature to obtain an aniline ortho-position trifluoromethylation product; li et al pyridine amide-oriented anilines and derivatives thereof and CF3SO2Na as raw material, CuCl2As a catalyst, (NH)4)2S2O8The aniline is subjected to ortho-trifluoromethylation by photocatalysis as an oxidant, and the reaction is also suitable for aniline which is not oriented by pyridine amide. However, these methods either use toxic and harmful reagents, large amounts of oxidizing agents and metal catalysts, and do not meet the requirements of green chemistry. Therefore, it is necessary to develop a method for synthesizing a selective trifluoromethylated aryl amide compound which does not use a metal catalyst and an oxidant and is environmentally friendly.
Compared with the previously reported method, the method does not use a large amount of oxidant and metal catalyst, has high yield and milder reaction condition.
Disclosure of Invention
The invention aims to provide a novel method for synthesizing trifluoromethyl aryl amide derivatives, which is green, friendly, simple, convenient and efficient.
The technical scheme of the invention is as follows:
an electrochemical synthesis method of trifluoromethylated aryl amide derivatives comprises the following steps:
adding a substrate aryl amide, a trifluoromethylation reagent, an electrolyte and a solvent into a reaction vessel provided with an electrode, stirring and reacting the reaction mixture at a constant current of 5-20mA (preferably 15mA) for 30-180min (preferably 120min) at 25-75 ℃ (preferably 50 ℃), and then carrying out post-treatment on the reaction solution to obtain a product of a trifluoromethylated aryl amide derivative;
the ratio of the amounts of the substrate arylamide to the amount of the substance of the trifluoromethylating agent is 1: 1.5; the trifluoromethyl reagent is sodium trifluoromethanesulfonate;
the ratio of the amount of substance of the substrate arylamide to the amount of substance of the electrolyte is 1: 0.3; the electrolyte is tetrabutylammonium tetrafluoroborate, tetrabutylammonium chloride, tetrabutylammonium bromide or tetrabutylammonium iodide, and tetrabutylammonium tetrafluoroborate is preferred;
the solvent is one or a mixed solvent of more than two of acetonitrile, acetone, dioxane and methanol in any proportion, and acetonitrile is preferred; the volume usage amount of the solvent is 2-10 mL/mmol, preferably 5mL/mmol, based on the amount of the substance of the substrate aryl amide;
the electrode is C (+) -Pt (-), C (+) -C (-), Pt (+) -Pt (-), Ni (+) -Pt (-), or Cu (+) -Pt (-), preferably C (+) -Pt (-);
the post-treatment method comprises the following steps: after the reaction is finished, the reaction solution is decompressed and concentrated, and is separated and purified by silica gel column chromatography, and the reaction solution is prepared by mixing petroleum ether: ethyl acetate volume ratio 20: 1 as developing agent, collecting eluent containing target compound, decompressing, evaporating and removing solvent, and drying to obtain product trifluoromethylated aryl amide derivative;
the structural formula of the substrate aryl amide is shown as a formula (Ia) or a formula (Ib), and correspondingly, the structural formula of the obtained product trifluoromethyl aryl amide derivative is shown as a formula (IIa) or a formula (IIb);
substrate:
the product is as follows:
in the formula (Ia) or the formula (IIa),
R1is pyridyl or substituted pyridyl, the pyridyl ring of the substituted pyridyl is mono-substituted by 1 substituent, the substituent is C1-C4 alkyl, or the substituent and the pyridyl ring are condensed to form quinolyl;
R2is H, C1-C4 alkyl, halogen, cyano or nitro, or R2Fused with the benzene ring to form a naphthyl;
in the formula (Ib) or the formula (IIb),
R3is C1-C4 alkyl, phenyl, substituted phenyl which is monosubstituted on the phenyl ring by 1 substituent, which is C1-C4 alkyl, C1-C4 alkoxy, halogen or nitro, or a heterocyclic ring such as: thiophene;
R4is H, C1-C4 alkyl or C1-C4 alkoxy on the quinoline skeleton.
The structure of the product obtained by the invention1H NMR、13C NMR, MS, HRMS and the like.
The invention has the beneficial effects that: in the prior art, toxic and harmful reagents, a large amount of oxidants and metal catalysts are adopted, so that the requirements of green chemistry are not met. The invention adopts an electrochemical method to synthesize the trifluoromethylated aryl amide compound, does not use a large amount of oxidant and metal catalyst, has high product yield, milder reaction condition and wide substrate applicability, and meets the requirement of green chemistry.
Detailed Description
The present invention is further illustrated by the following specific examples, but the scope of the present invention is not limited thereto.
Example 1
In a 10mL three-necked flask equipped with a carbon anode (d ═ 6mm), a platinum plate (1cm × 1cm) cathode, N-phenylpyridyl amide (0.3mmol,59.5mg), sodium trifluoromethanesulfonate (0.45mmol,70.2mg), tetrabutylammonium bromide (0.3eq, 29.0mg) were added. Acetonitrile (3.0mL) was added. The reaction mixture was stirred at 50 ℃ for 120min at a constant current of 15 mA. After the reaction was complete, TLC detection was performed and the reaction mixture was concentrated under reduced pressure. Purification was performed by silica gel column chromatography to obtain the objective product a as a white solid (54.3 mg, yield 68%).
1H NMR(400MHz,CDCl3)10.60(s,1H),8.60(d,J＝4.7Hz,1H),8.53(d,J＝8.3Hz,1H),8.24(d,J＝7.8Hz,1H),7.86(td,J＝7.7,1.7Hz,1H),7.61(d,J＝7.7Hz,1H),7.55(t,J＝7.7Hz,1H),7.44(ddd,J＝7.6,4.8,1.1Hz,1H),7.18(d,J＝7.7Hz,1H).13C NMR(100MHz,CDCl3)161.18,148.09,147.08,136.42,134.28(q,J＝2.5Hz),131.69,126.15(q,J＝5.0Hz),125.48,123.98(q,J＝273.4Hz),122.77,121.80,121.25,118.72(q,J＝30.3Hz).19F NMR(376MHz,CDCl3)-60.94.Calculated for C13H9F3N2OH:[M+H]+267.0745,Found267.0745.
Example 2
In a 10mL three-necked flask equipped with a carbon anode (d ═ 6mm), a platinum plate (1cm × 1cm) cathode, N- (p-tolyl) picolinamide (0.3mmol,63.7mg), sodium trifluoromethanesulfonate (0.45mmol,70.2mg), tetrabutylammonium bromide (0.3eq, 29.0mg) were added. Acetonitrile (3.0mL) was added. The reaction mixture was stirred at 50 ℃ for 120min at a constant current of 15 mA. After the reaction was complete, TLC detection was performed and the reaction mixture was concentrated under reduced pressure. Purification was performed by silica gel column chromatography to obtain the objective product b as a white solid (54.6 mg, 65% yield).
1H NMR(400MHz,CDCl3)10.57(s,1H),8.68(d,J＝4.4Hz,1H),8.43(d,J＝8.4Hz,1H),8.31(d,J＝7.8Hz,1H),7.93(td,J＝7.7,1.7Hz,1H),7.52(ddd,J＝7.6,4.8,1.1Hz,1H),7.48(s,1H),7.43(d,J＝8.4Hz,1H),2.42(s,3H).13C NMR(100MHz,CDCl3)162.36,149.46,148.29,137.66,134.09,133.41(q,J＝1.3Hz),,132.89(q,J＝1.3Hz),126.64,126.55(q,J＝5.0Hz),124.43(q,J＝273.4Hz),123.29,122.48,120.01(q,J＝30.3Hz),20.86.19F NMR(376MHz,CDCl3)-60.83.Calculated for C14H11F3N2OH:[M+H]+281.0902,Found 281.0900.
Example 3
In a 10mL three-necked flask equipped with a carbon anode (d ═ 6mm), a platinum plate (1cm × 1cm) cathode, N- (4-bromophenyl) picolinamide (0.3mmol,83.2mg), sodium trifluoromethanesulfonate (0.45mmol,70.2mg), tetrabutylammonium bromide (0.3eq, 29.0mg) were added. Acetonitrile (3.0mL) was added. The reaction mixture was stirred at 50 ℃ for 120min at a constant current of 15 mA. After the reaction was complete, TLC detection was performed and the reaction mixture was concentrated under reduced pressure. Purification was performed by silica gel column chromatography to obtain the objective product c as a white solid (62.1 mg, yield 60%).
1H NMR(400MHz,CDCl3)10.69(s,1H),8.67(d,J＝4.2Hz,1H),8.57(d,J＝8.9Hz,1H),8.29(d,J＝7.8Hz,1H),7.93(td,J＝7.7,1.6Hz,1H),7.79(d,J＝1.9Hz,1H),7.73(d,J＝8.9Hz,1H),7.53(ddd,J＝7.6,4.8,1.1Hz,1H).13C NMR(101MHz,CDCl3)161.35,148.05,147.34,136.72,134.86,133.75(q,J＝1.0Hz),130.14(q,J＝5.0Hz),125.87,123.34,122.18(q,J＝274.2Hz),121.53,120.22(q,J＝31.3Hz),115.54.19F NMR(376MHz,CDCl3)-61.28.Calculated for C13H8BrF3N2OH:[M+H]+344.9850,Found 344.9855.
Example 4
In a 10mL three-necked flask equipped with a carbon anode (d ═ 6mm), a platinum plate (1cm × 1cm) cathode, N- (4-cyanophenyl) picolinamide (0.3mmol,67.0mg), sodium trifluoromethanesulfonate (0.45mmol,70.2mg), tetrabutylammonium bromide (0.3eq, 29.0mg) were added. Acetonitrile (3.0mL) was added. The reaction mixture was stirred at 50 ℃ for 120min at a constant current of 15 mA. After the reaction was complete, TLC detection was performed and the reaction mixture was concentrated under reduced pressure. Purification was performed by silica gel column chromatography to obtain the objective product d as a white solid (34.9 mg, 40% yield).
1H NMR(400MHz,CDCl3)11.02(s,1H),8.96(d,J＝8.7Hz,1H),8.70(d,J＝4.2Hz,1H),8.32(d,J＝7.8Hz,1H),7.98(td,J＝7.7,1.7Hz,2H),7.90(dd,J＝8.7,1.7Hz,1H),7.58(ddd,J＝7.6,4.8,1.1Hz,1H).13C NMR(101MHz,CDCl3)162.73,148.61,139.77,138.10,136.87,130.53(q,J＝5.0Hz),127.48,123.14(q,J＝274.7Hz),122.90,122.46,122.37,119.81(q,J＝31.5Hz),117.74,107.28.19F NMR(376MHz,CDCl3)-61.71.Calculated for C14H8F3N3OH:[M+H]+292.0618,Found 292.0615.
Example 5
In a 10mL three-necked flask equipped with a carbon anode (d ═ 6mm), a platinum plate (1cm × 1cm) cathode, N- (o-tolyl) picolinamide (0.3mmol,63.7mg), sodium trifluoromethanesulfonate (0.45mmol,70.2mg), tetrabutylammonium bromide (0.3eq, 29.0mg) were added. Acetonitrile (3.0mL) was added. The reaction mixture was stirred at 50 ℃ for 120min at a constant current of 15 mA. After the reaction was complete, TLC detection was performed and the reaction mixture was concentrated under reduced pressure. Purification was carried out by silica gel column chromatography to obtain the objective product e as a white solid (25.2 mg, yield 30%).
1H NMR(400MHz,CDCl3)9.83(s,1H),8.67(d,J＝4.2Hz,1H),8.30(d,J＝7.8Hz,1H),7.92(t,J＝7.7Hz,1H),7.58(d,J＝7.7Hz,1H),7.53(d,J＝7.1Hz,2H),7.36(t,J＝7.7Hz,1H),2.37(s,3H).13CNMR(101MHz,CDCl3)162.92,149.36,148.49,138.94,137.64,134.81,133.33(q,J＝1.0Hz),127.57,127.26,126.76,124.04(q,J＝5.0Hz),123.94(q,J＝273.7Hz),122.77,18.62.19F NMR(376MHz,CDCl3)-61.68.Calculated forC14H11F3N2OH:[M+H]+281.0902,Found 281.0905.
Example 6
In a 10mL three-necked flask equipped with a carbon anode (d ═ 6mm), a platinum plate (1cm × 1cm) cathode, N- (2-fluorophenyl) picolinamide (0.3mmol,64.9mg), sodium trifluoromethanesulfonate (0.45mmol,70.2mg), tetrabutylammonium bromide (0.3eq, 29.0mg) were added. Acetonitrile (3.0mL) was added. The reaction mixture was stirred at 50 ℃ for 120min at a constant current of 15 mA. After the reaction was complete, TLC detection was performed and the reaction mixture was concentrated under reduced pressure. Purification was performed by silica gel column chromatography to obtain the objective product f as a white solid (27.3 mg, yield 32%).
1H NMR(400MHz,CDCl3)9.75(s,1H),8.67(d,J＝4.7Hz,1H),8.30(d,J＝7.8Hz,1H),7.93(td,J＝7.7,1.6Hz,1H),7.56–7.51(m,2H),7.43(dd,J＝7.9,3.9Hz,2H).13C NMR(100MHz,CDCl3)162.84,158.64(d,J＝255.5),148.88,148.51,137.69,128.63(q,J＝1.0Hz),128.34(d,J＝9.1Hz),126.97,124.50(q,J＝273.7Hz),122.89,121.97(q,J＝30.3Hz),121.88(q,J＝5.0Hz),120.62(d,J＝21.2Hz).19F NMR(376MHz,Chloroform-d)-61.35,-114.23.Calculated for C13H8F4N2OH:[M+H]+285.0651,Found 285.0651.
Example 7
In a 10mL three-necked flask equipped with a carbon anode (d ═ 6mm), a platinum plate (1cm × 1cm) cathode, N- (quinolin-8-yl) benzamide (0.3mmol,74.4mg) sodium trifluoromethanesulfonate (0.45mmol,70.2mg), tetrabutylammonium fluoroborate (0.3eq, 29.0mg) were added. Acetonitrile (3.0mL) was added. The reaction mixture was stirred at 50 ℃ for 120min at a constant current of 15 mA. After the reaction was complete, TLC detection was performed and the reaction mixture was concentrated under reduced pressure. Purification was carried out by silica gel column chromatography to obtain the objective product g as a white solid (67 mg, yield 71%).
1H NMR(400MHz,CDCl3)10.93(s,1H),8.97(d,J＝8.2Hz,1H),8.94(dd,J＝4.2,1.4Hz,1H),8.55(dt,J＝8.6,1.7Hz,1H),8.13–8.08(m,2H),7.98(d,J＝8.2Hz,1H),7.66–7.55(m,4H).13C NMR(101MHz,CDCl3)165.62,148.71,138.55,138.10,134.58,133.25(q,J＝2.0Hz),132.26,128.91,127.36,126.62(q,J＝6.1Hz),124.29(q,J＝273.2.3Hz),124.29,122.88,119.68(q,J＝31.3Hz),114.19.19F NMR(376MHz,CDCl3)-58.69.HRMS(ESI+):Calculated for C17H11F3N2OH:[M+H]+317.0902,Found 317.0909
Example 8
In a 10mL three-necked flask equipped with a carbon anode (d ═ 6mm), a platinum plate (1cm × 1cm) cathode, 4-methyl-N- (quinolin-8-yl) benzamide (0.3mmol,78.6mg) sodium trifluoromethanesulfonate (0.45mmol,70.2mg), tetrabutylammonium fluoroborate (0.3eq, 29.0mg) were added. Acetonitrile (3.0mL) was added. The reaction mixture was stirred at 50 ℃ for 120min at a constant current of 15 mA. After the reaction was complete, TLC detection was performed and the reaction mixture was concentrated under reduced pressure. Purification was carried out by silica gel column chromatography to obtain the objective product h as a white solid (74.2 mg, yield 75%).
1H NMR(400MHz,CDCl3)10.89(s,1H),8.95(dd,J＝10.8,6.1Hz,2H),8.53(d,J＝8.4Hz,1H),7.98(t,J＝9.0Hz,3H),7.62(dd,J＝8.6,4.1Hz,1H),7.37(d,J＝7.7Hz,2H),2.48(s,3H).13C NMR(101MHz,CDCl3)165.58,148.66,142.86,138.54,138.21,133.21，131.75,129.56,127.37,126.62(q,J＝6.1Hz),124.29，124.30(q,J＝273.2Hz),122.83,119.48(q,J＝31.3Hz),114.08,21.57.19F NMR(376MHz,CDCl3)-58.67.HRMS(ESI+):Calculated for C18H13F3N2OH:[M+H]+331.1058,Found 331.1058.
Example 9
In a 10mL three-necked flask equipped with a carbon anode (d ═ 6mm), a platinum plate (1cm × 1cm) cathode, 4-methoxy-N- (quinolin-8-yl) benzamide (0.3mmol,83.4mg) sodium trifluoromethanesulfonate (0.45mmol,70.2mg), tetrabutylammonium fluoroborate (0.3eq, 29.0mg) were added. Acetonitrile (3.0mL) was added. The reaction mixture was stirred at 50 ℃ for 120min at a constant current of 15 mA. After the reaction was complete, TLC detection was performed and the reaction mixture was concentrated under reduced pressure. Purification was carried out by silica gel column chromatography to obtain the objective product i as a white solid (74.7 mg, yield 72%).
1H NMR(400MHz,CDCl3)10.87(s,1H),8.98–8.93(m,2H),8.55(d,J＝8.6Hz,1H),8.08(d,J＝8.7Hz,2H),7.97(d,J＝8.2Hz,1H),7.63(dd,J＝8.7,4.2Hz,1H),7.07(d,J＝8.7Hz,2H),3.92(s,3H).13C NMR(101MHz,None)165.17,162.86,148.63,138.55,138.31,133.25,129.33,126.86,126.70(q,J＝6.1Hz),124.33 124.32(q,J＝273.4Hz),122.84,119.36(q,J＝31.3Hz),114.12,114.02,55.52.19F NMR(376MHz,CDCl3)-58.65.HRMS(ESI+):Calculated for C18H13F3N2O2H:[M+H]+347.1007,Found 347.1009.
Example 10
In a 10mL three-necked flask equipped with a carbon anode (d ═ 6mm), a platinum plate (1cm × 1cm) cathode, 4-bromo-N- (quinolin-8-yl) benzamide (0.3mmol,98.1mg) sodium trifluoromethanesulfonate (0.45mmol,70.2mg), tetrabutylammonium fluoroborate (0.3eq, 29.0mg) were added. Acetonitrile (3.0mL) was added. The reaction mixture was stirred at 50 ℃ for 120min at a constant current of 15 mA. After the reaction was complete, TLC detection was performed and the reaction mixture was concentrated under reduced pressure. Purification was performed by silica gel column chromatography to obtain the objective product j as a white solid (83.0 mg, yield 70%).
1H NMR(400MHz,CDCl3)10.90(s,1H),8.94(d,J＝8.7Hz,2H),8.56(d,J＝8.7Hz,1H),8.01–7.94(m,3H),7.72(d,J＝8.5Hz,2H),7.65(dd,J＝8.7,4.2Hz,1H).13C NMR(101MHz,CDCl3)164.63,148.79,138.49,137.81,133.41,132.18,128.94,127.13,126.92(q,J＝273.2Hz),126.60(q,J＝6.1Hz),124.31,123.10,122.96,119.96(q,J＝31.5Hz),114.31.19F NMR(376MHz,CDCl3)-58.73.HRMS(ESI+):Calculated for C17H10BrF3N2OH:[M+H]+395.0007,Found 395.0002.
Example 11
In a 10mL three-necked flask equipped with a carbon anode (d ═ 6mm), a platinum plate (1cm × 1cm) cathode, 2-methyl-N- (quinolin-8-yl) benzamide (0.3mmol,78.6mg) sodium trifluoromethanesulfonate (0.45mmol,70.2mg), tetrabutylammonium fluoroborate (0.3eq, 29.0mg) were added. Acetonitrile (3.0mL) was added. The reaction mixture was stirred at 50 ℃ for 120min at a constant current of 15 mA. After the reaction was complete, TLC detection was performed and the reaction mixture was concentrated under reduced pressure. Purification was performed by silica gel column chromatography to obtain the objective product k as a white solid (78.2 mg, 79% yield).
1H NMR(400MHz,CDCl3)10.44(s,1H),8.99(d,J＝8.2Hz,1H),8.88(d,J＝4.0Hz,1H),8.55(d,J＝8.5Hz,1H),8.00(d,J＝8.2Hz,1H),7.72(d,J＝7.4Hz,1H),7.62(dd,J＝8.7,4.2Hz,1H),7.46(t,J＝7.3Hz,1H),7.37(t,J＝7.6Hz,2H),2.64(s,3H).13C NMR(101MHz,CDCl3)168.35,148.70,138.43,138.25,136.95,136.01,133.21(q,J＝2.0Hz),131.56,130.72,127.28,126.60(q,J＝6.1Hz),126.12,124.33,124.27(q,J＝273.2Hz),122.86,119.80(q,J＝31.3Hz),114.17,20.26.19F NMR(376MHz,CDCl3)-58.70.HRMS(ESI+):Calculated for C18H13F3N2OH:[M+H]+331.1058,Found 331.1052.
Example 12
In a 10mL three-necked flask equipped with a carbon anode (d ═ 6mm), a platinum plate (1cm × 1cm) cathode, 2-chloro-N- (quinolin-8-yl) benzamide (0.3mmol,84.6mg) sodium trifluoromethanesulfonate (0.45mmol,70.2mg), tetrabutylammonium fluoroborate (0.3eq, 29.0mg) were added. Acetonitrile (3.0mL) was added. The reaction mixture was stirred at 50 ℃ for 120min at a constant current of 15 mA. After the reaction was complete, TLC detection was performed and the reaction mixture was concentrated under reduced pressure. Purification was carried out by silica gel column chromatography to obtain the objective product i as a white solid (76.7 mg, 73% yield).
1H NMR(400MHz,CDCl3)10.74(s,1H),9.00(d,J＝8.2Hz,1H),8.90(dd,J＝4.2,1.4Hz,1H),8.55(dt,J＝8.7,1.6Hz,1H),8.00(d,J＝8.2Hz,1H),7.86(dd,J＝7.3,2.0Hz,1H),7.63(dd,J＝8.7,4.2Hz,1H),7.55(dd,J＝7.8,1.5Hz,1H),7.52–7.42(m,2H).13C NMR(101MHz,CDCl3)165.16,148.83,138.48,137.92,135.24,133.20,131.92,131.19,130.65,130.28,127.28,126.54(q,J＝6.1Hz),124.32,124.22(q,J＝273.2Hz)122.92,120.18(q,J＝31.3Hz),114.61.19F NMR(376MHz,CDCl3)-58.76.HRMS(ESI+):Calculatedfor C17H10ClF3N2OH:[M+H]+351.0512,Found 351.0510.
Example 13
In a 10mL three-necked flask equipped with a carbon anode (d ═ 6mm), a platinum plate (1cm × 1cm) cathode, 3-methoxy-N- (quinolin-8-yl) benzamide (0.3mmol,83.4mg) sodium trifluoromethanesulfonate (0.45mmol,70.2mg), tetrabutylammonium fluoroborate (0.3eq, 29.0mg) were added. Acetonitrile (3.0mL) was added. The reaction mixture was stirred at 50 ℃ for 120min at a constant current of 15 mA. After the reaction was complete, TLC detection was performed and the reaction mixture was concentrated under reduced pressure. Purification was carried out by silica gel column chromatography to obtain the objective product m as a white solid (80.0 mg) in a yield of 77%.
1H NMR(400MHz,CDCl3)10.90(s,1H),8.97–8.91(m,2H),8.57–8.50(m,1H),7.97(d,J＝8.2Hz,1H),7.69–7.59(m,3H),7.52–7.44(m,1H),7.19–7.11(m,1H),3.94(s,3H).13CNMR(101MHz,CDCl3)165.46,160.06,148.74,138.51,138.04,136.01,133.20,129.89,126.59(q,J＝6.1Hz),124.27,124.26(q,J＝273.2Hz),122.74,119.68(q,J＝31.3Hz),119.09,118.35,114.16,112.80,55.53.19F NMR(376MHz,CDCl3)-58.69.HRMS(ESI+):Calculated for C18H13F3N2O2H:[M+H]+347.1007,Found 347.1008.
Example 14
In a 10mL three-necked flask equipped with a carbon anode (d ═ 6mm), a platinum plate (1cm × 1cm) cathode, N- (quinolin-8-yl) acetamide (0.3mmol,55.8mg) sodium trifluoromethanesulfonate (0.45mmol,70.2mg), tetrabutylammonium fluoroborate (0.3eq, 29.0mg) were added. Acetonitrile (3.0mL) was added. The reaction mixture was stirred at 50 ℃ for 120min at a constant current of 15 mA. After the reaction was complete, TLC detection was performed and the reaction mixture was concentrated under reduced pressure. Purification was performed by silica gel column chromatography to obtain the desired product n as a white solid (53.3 mg, yield 70%).
1H NMR(400MHz,CDCl3)9.97(s,1H),8.91–8.85(m,1H),8.78(d,J＝8.2Hz,1H),8.50(d,J＝8.7Hz,1H),7.90(d,J＝8.2Hz,1H),7.59(dd,J＝8.7,4.2Hz,1H),2.39(s,3H).13C NMR(101MHz,CDCl3)169.08,148.52,137.98,133.16,133.14,126.54(q,J＝6.1Hz),124.20,124.24(q,J＝273.1Hz),122.77,119.45(q,J＝30.3Hz),114.00,25.18.19F NMR(376MHz,CDCl3)-58.74.HRMS(ESI+):Calculated for C12H9F3N2OH:[M+H]+255.0745,Found 255.0744.
Example 15
In a 10mL three-necked flask equipped with a carbon anode (d ═ 6mm), a platinum plate (1cm × 1cm) cathode, N- (quinolin-8-yl) thiophene-2-carboxamide (0.3mmol,76.2mg) sodium trifluoromethanesulfonate (0.45mmol,70.2mg), tetrabutylammonium fluoroborate (0.3eq, 29.0mg) were added. Acetonitrile (3.0mL) was added. The reaction mixture was stirred at 50 ℃ for 120min at a constant current of 15 mA. After the reaction was complete, TLC detection was performed and the reaction mixture was concentrated under reduced pressure. Purification was performed by silica gel column chromatography to obtain the objective product o as a white solid (70.5 mg, 73% yield).
1H NMR(400MHz,CDCl3)10.78(s,1H),8.95(dd,J＝4.2,1.4Hz,1H),8.88(d,J＝8.2Hz,1H),8.55(dt,J＝8.7,1.6Hz,1H),7.97(d,J＝8.2Hz,1H),7.88(dd,J＝3.7,0.9Hz,1H),7.67–7.62(m,2H),7.23(dd,J＝4.9,3.8Hz,1H).13C NMR(101MHz,CDCl3)160.20,148.76,139.46,138.30,137.84,133.28(q,J＝2.0Hz),131.60,128.92,128.63,126.61(q,J＝6.1Hz),124.31,124.25(q,J＝273.1Hz),122.93,119.68(q,J＝31.3Hz),114.15.19FNMR(376MHz,CDCl3)-58.71.HRMS(ESI+):Calculated for C15H9F3N2OSH:[M+H]+323.0466,Found 323.0469.
Example 16
In a 10mL three-necked flask equipped with a carbon anode (d ═ 6mm), a platinum plate (1cm × 1cm) cathode, N- (2-methylquinolin-8-yl) benzamide (0.3mmol,78.6mg) sodium trifluoromethanesulfonate (0.45mmol,70.2mg), tetrabutylammonium fluoroborate (0.3eq, 29.0mg) were added. Acetonitrile (3.0mL) was added. The reaction mixture was stirred at 50 ℃ for 120min at a constant current of 15 mA. After the reaction was complete, TLC detection was performed and the reaction mixture was concentrated under reduced pressure. Purification was carried out by silica gel column chromatography to obtain the desired product p as a white solid (77.2 mg, 78% yield).
1H NMR(400MHz,CDCl3)11.01(s,1H),8.93(d,J＝8.2Hz,1H),8.44–8.40(m,1H),8.10(d,J＝6.8Hz,2H),7.90(d,J＝8.2Hz,1H),7.65–7.58(m,3H),7.50(d,J＝8.8Hz,1H),2.83(s,3H).13CNMR(101MHz,CDCl3)165.55,157.94,138.03,137.41,134.74,133.25(q,J＝2.0Hz),132.20,128.94,127.32,125.48(q,J＝6.1Hz),124.36(q,J＝273.1Hz),123.74,122.40,119.59(q,J＝31.3Hz),114.19,25.33.19F NMR(376MHz,CDCl3)-58.76.HRMS(ESI+):Calculated for C18H13F3N2OH:[M+H]+331.1058,Found 331.1555.
Example 17
In a 10mL three-necked flask equipped with a carbon anode (d ═ 6mm), a platinum plate (1cm × 1cm) cathode, N- (6-methoxyquinolin-8-yl) benzamide (0.3mmol,83.4mg) sodium trifluoromethanesulfonate (0.45mmol,70.2mg), tetrabutylammonium fluoroborate (0.3eq, 29.0mg) were added. Acetonitrile (3.0mL) was added. The reaction mixture was stirred at 50 ℃ for 120min at a constant current of 15 mA. After the reaction was complete, TLC detection was performed and the reaction mixture was concentrated under reduced pressure. Purification was carried out by silica gel column chromatography to obtain the objective product q as a white solid (83.04 mg, yield 80%).
Claims (7)
1. An electrochemical synthesis method of trifluoromethylated aryl amide derivatives is characterized in that the method comprises the following steps:
adding a substrate aryl amide, a trifluoromethyl reagent, an electrolyte and a solvent into a reaction container with an electrode, stirring and reacting the reaction mixture at a constant current of 5-20mA for 30-180min at 25-75 ℃, and then carrying out post-treatment on the reaction solution to obtain a product trifluoromethyl aryl amide derivative;
the ratio of the amounts of the substrate arylamide to the amount of the substance of the trifluoromethylating agent is 1: 1.5; the trifluoromethyl reagent is sodium trifluoromethanesulfonate;
the ratio of the amount of substance of the substrate arylamide to the amount of substance of the electrolyte is 1: 0.3; the electrolyte is tetrabutylammonium tetrafluoroborate, tetrabutylammonium chloride, tetrabutylammonium bromide or tetrabutylammonium iodide;
the structural formula of the substrate aryl amide is shown as a formula (Ia) or a formula (Ib), and correspondingly, the structural formula of the obtained product trifluoromethyl aryl amide derivative is shown as a formula (IIa) or a formula (IIb);
substrate:
the product is as follows:
in the formula (Ia) or the formula (IIa),
R1is pyridyl or substituted pyridyl, the pyridyl ring of the substituted pyridyl is mono-substituted by 1 substituent, the substituent is C1-C4 alkyl, or the substituent and the pyridyl ring are condensed to form quinolyl;
R2is H, C1-C4 alkyl, halogen, cyano or nitro, or R2Fused with the benzene ring to form a naphthyl;
in the formula (Ib) or the formula (IIb),
R3is C1-C4 alkyl, phenyl, substituted phenyl or heterocycle, the benzene ring of the substituted phenyl is mono-substituted by 1 substituent, and the substituent is C1-C4 alkyl, C1-C4 alkoxy, halogen or nitro;
R4is quinolineH, C1-C4 alkyl or C1-C4 alkoxy on the backbone.
2. The method for electrochemically synthesizing trifluoromethylated arylamide derivatives according to claim 1, wherein the reaction mixture is stirred at a constant current of 15mA at 50 ℃ for 120 min.
3. The method for the electrochemical synthesis of trifluoromethylated arylamide derivatives according to claim 1, wherein the electrolyte is tetrabutylammonium tetrafluoroborate.
4. The electrochemical synthesis method of a trifluoromethylated arylamide derivative according to claim 1, wherein the solvent is one or a mixed solvent of two or more of acetonitrile, acetone, dioxane, and methanol at any ratio.
5. The electrochemical synthesis method of a trifluoromethylated arylamide derivative according to claim 1, wherein the volume usage of the solvent is 2 to 10mL/mmol based on the substance amount of the substrate arylamide.
6. The method for electrochemical synthesis of a trifluoromethylated aryl amide derivative according to claim 1, wherein the electrode is C (+) -Pt (-), C (+) -C (-), Pt (+) -Pt (-), Ni (+) -Pt (-), or Cu (+) -Pt (-).
7. The electrochemical synthesis process of trifluoromethylated arylamide derivatives according to claim 1, wherein the post-treatment process comprises: after the reaction is finished, the reaction solution is decompressed and concentrated, and is separated and purified by silica gel column chromatography, and the reaction solution is prepared by mixing petroleum ether: ethyl acetate volume ratio 20: 1 as developing agent, collecting eluent containing target compound, decompressing, evaporating and removing solvent, and drying to obtain product trifluoromethylated aryl amide derivative.
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| CN113549939A (en) * | 2021-07-08 | 2021-10-26 | 南京先进生物材料与过程装备研究院有限公司 | Method for continuously electrically synthesizing isoindolinone by using micro-reaction device |
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| CN113549939A (en) * | 2021-07-08 | 2021-10-26 | 南京先进生物材料与过程装备研究院有限公司 | Method for continuously electrically synthesizing isoindolinone by using micro-reaction device |
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| CN114395770B (en) * | 2022-01-25 | 2023-09-22 | 上海电力大学 | Method for electrochemically synthesizing 5-trifluoromethyl uracil compound |
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