CN1116906C - Process for compounding and preparing bio-medical composition - Google Patents
Process for compounding and preparing bio-medical composition Download PDFInfo
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- CN1116906C CN1116906C CN 01114210 CN01114210A CN1116906C CN 1116906 C CN1116906 C CN 1116906C CN 01114210 CN01114210 CN 01114210 CN 01114210 A CN01114210 A CN 01114210A CN 1116906 C CN1116906 C CN 1116906C
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- hydroxyapatite
- polylactic acid
- thin slice
- medical composition
- preparation
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Abstract
The present invention relates to a method for compounding and preparing a biomedical polymer composite material. A liquid phase adsorption method is mainly adopted to adsorb particles of inorganic material on matrices of organic polymer material, and the particles and the matrices are directly molded through hot pressing to prepare the absorbable composite material with favorable biocompatibility and high strength. With the advantages of convenient processing, low price, convenient use, wide range of application, etc., the method for compounding and preparing the biomedical polymer composite material can be used for manufacturing materials for repairing and replacing hard tissues of human bodies and is a novel technique of biomedical polymer composite materials, which has great popularization value.
Description
Compound and the preparation method of biological medical polymer composite.The bio-medical composition of the present invention's preparation belongs to repairs, replaces the material of tissue in the surgery implantation.
By the composite that inorganic material and macromolecular material are composited, the method that adopts mainly contains usually: methods such as mechanical blending method, polymerization filling.
The mechanical blending method: it is to rely on physical action to realize inorganic filler and organic polymer blend, the bio-medical composition preparation process mainly is to utilize melt blended method, the polymers compositions that blend is used is dispersed in inorganic material particles on the polymer melt with the equipment of mixing more than their flow temperature, by compacting, injection or extrusion molding, prepare the composite of different shape then.Because the mechanical blending method has intensive shear action and heat effect often makes a part of polymer degrade, make the performance of material be affected and be difficult to absorb, there is because two kinds of material mixing degree inequalities the molecular weight problem such as fast that decays in addition.
It is simple to the invention provides a kind of technology, compound and the preparation method that price is low, the technology of preparing of the biological medical polymer material (polylactic acid, poly-methyl-prop diluted acid, first polyglycolic acid, poly-anhydride etc.) that adopts this method to prepare to have excellent biological compatibility and absorbability and the composite of medical inorganic material (hydroxyapatite, calcium carbonate etc.).
Characteristics of the present invention are to adopt liquid phase adsorption method.That is: the biologic inorganic material is adsorbed on employing straight forming method on the bio-medical high-molecular organic material thin slice, prepares bio-medical composition.
The present invention realizes in the following manner:
Fig. 1 is a process chart of the present invention
One, will have absorbable biological medicinal high-molecular organic material body and cut into 0.1～0.2mm thin slice. Two, more medical inorganic material particle is disperseed in organic solution, classification, make micro mist. Particle diameter 0.05～2 μ m of micro mist. Three, medical particulate inorganic material and medical high-molecular organic material being reached evenly compound is key of the present invention. Adopt liquid phase adsorption method namely the micro mist of medical inorganic material to be mixed with organic solvent, get the top mixed liquor, suitably take out according to desired particle size, thin slice with medical high-molecular organic material adds abundant mixing in the mixed liquor again, treat solvent evaporates, adsorb the particle of the uniform medical inorganic material of one deck at the medical high-molecular organic material thin slice of cutting, and form even complex. As required even complex is placed in the mould, adopts direct hot press forming technology to obtain the medical composite material goods of the shapes such as desirable silk, cylinder, flat board, internal fixation bar, screw and fixed head.
Embodiment
With the method for preparing polylactic acid and hydroxyapatite composite material the present invention is described: 1, adopt indirect method, polylactic acid is synthesized the PDLLA of absolute molecular weight in a certain scope.Concrete chemical equation is as follows:
Solve the synthesis technique of polylactic acid, determined best synthesis condition, obtained being suitable for the molecular weight of internal fixation device and the polylactic acid of narrow molecular weight distribution.2, the hydroxyapatite micropowder is synthetic: adopt chemical liquid phase-sedimentation method to prepare HA, promptly utilize the neutralization reaction of calcium hydroxide and phosphoric acid to generate hydroxyapatite, chemical equation is as follows:
Concrete preparation method is with H
3PO
4Solution slowly splashes into Ca (OH)
2Dope in, constantly stir, temperature is controlled at 60 ℃, final PH reaches 9,7 hours response time.And after the uniform temperature calcining, levigate sieving places vacuum desiccator interior standby.3, polylactic acid/hydroxy apatite is compound
Polylactic acid and the evenly preparation of complex, at first the hydroxyapatite micropowder is mixed vibration with organic solvent, get suspension (the hydroxyapatite particle diameter is 0.12 μ m), again with polylactic acid thin slice (thickness is below 0.2mm), add in the hydroxyapatite suspension, abundant mixing, treat solvent evaporates after, be formed on the complex of the even hydroxyapatite particles of absorption one deck on the polylactic acid thin slice.
With the acquired homogeneous phase complex mould of packing into, adopt direct heat molded, thereby reduce the decay of polylactic acid molecule amount, obtain the ideal uniform medical composite material.
Be to adopt the hydroxyapatite of this method preparation and the mechanical property of lactic acid composite material below
Table 1 polylactic acid and hydroxyapatite (being called for short PDLLA/HA)
The mechanical property of composite
| The HA/PLLA mass ratio | Sticking all relative molecular mass MV | Bending strength (MPa) | Elastic modelling quantity (GPa) | Tensile strength (MPa) | Comprcssive strength (MPa) | Shearing strength (MPa) |
| 0/100 | 300000 | 258.5 | 6.5 | 154.1 | 123.5 | 93.0 |
| 20/80 | 212000 | 263.7 | 7.0 | 120.3 | 122.9 | |
| 30/70 | 250000 | 279.6 | 7.8 | 93.9 | 118.9 | 134.4 |
| 40/60 | 208000 | 276.0 | 9.8 | 91.3 | 108.2 | 136.1 |
| 50/50 | 210000 | 213.9 | 12.1 | 124.2 | 106.7 |
Claims (3)
1, the compound and preparation method of bio-medical composition is characterized in that utilizing liquid phase adsorption method, at first, the high-molecular organic material polylactic acid is processed into thin slice, and the inorganic material hydroxyapatite is made micropowder through calcining, grinding; Then, earlier the hydroxyapatite micropowder is mixed vibration with organic solvent, get its suspension, the polylactic acid thin slice is added in the hydroxyapatite suspension fully mix again, be formed on the complex of the even hydroxyapatite particles of absorption one deck on the polylactic acid thin slice; At last, complex is placed in the mould, direct heat is molded, prepares ideal composite.
2, according to the compound and preparation method of the described bio-medical composition of claim 1, the thickness that it is characterized in that described polylactic acid thin slice is 0.1-0.2mm, the grain diameter average out to 0.05-2 μ m of hydroxyapatite.
3,, it is characterized in that the goods of the plastic cylinder of described mould, flat board, silk according to the compound and preparation method of the described bio-medical composition of claim 1.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 01114210 CN1116906C (en) | 2001-05-22 | 2001-05-22 | Process for compounding and preparing bio-medical composition |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 01114210 CN1116906C (en) | 2001-05-22 | 2001-05-22 | Process for compounding and preparing bio-medical composition |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1325735A CN1325735A (en) | 2001-12-12 |
| CN1116906C true CN1116906C (en) | 2003-08-06 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 01114210 Expired - Lifetime CN1116906C (en) | 2001-05-22 | 2001-05-22 | Process for compounding and preparing bio-medical composition |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1116906C (en) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100427283C (en) * | 2004-10-09 | 2008-10-22 | 武汉理工大学 | Directly heating, pressing and forming method for polylactic acid and hydroxy apatite composite material |
| US20090263458A1 (en) * | 2008-04-21 | 2009-10-22 | Lasse Daniel Efskind | Material for surgical use in traumatology |
| CN105264014A (en) * | 2013-05-16 | 2016-01-20 | 株式会社索夫塞拉 | Biodegradable material |
-
2001
- 2001-05-22 CN CN 01114210 patent/CN1116906C/en not_active Expired - Lifetime
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| Publication number | Publication date |
|---|---|
| CN1325735A (en) | 2001-12-12 |
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Owner name: WUHUAN UNIVERSITY OF TECHNOLOGY ENTERPRISE GROUP C Free format text: FORMER OWNER: WUHAN UNIVERSITY OF TECHNOLOGY Effective date: 20120319 Owner name: WUHAN HUAWEI BIO-MATERIALS + ENGINEERING CO., LTD. Free format text: FORMER OWNER: WUHUAN UNIVERSITY OF TECHNOLOGY ENTERPRISE GROUP CO., LTD. Effective date: 20120319 |
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Effective date of registration: 20120319 Address after: 430070 Hubei Province, Wuhan city Hongshan District Luoshi Road No. 122 Patentee after: Wuhan Huawei Biological Material Engineering Co.,Ltd. Address before: 430070 Hubei city of Wuhan province Wuchang Luoshi Road No. 205 Patentee before: Wuhan Institute of Technology Industry Group Co.,Ltd. Effective date of registration: 20120319 Address after: 430070 Hubei city of Wuhan province Wuchang Luoshi Road No. 205 Patentee after: Wuhan Institute of Technology Industry Group Co.,Ltd. Address before: 430070 Hubei city of Wuhan province Wuchang Luoshi Road No. 122 Patentee before: Wuhan University of Technology |
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Granted publication date: 20030806 |