CN1116867C - Process for preparing ointment suppository contained in plastic bag - Google Patents
Process for preparing ointment suppository contained in plastic bag Download PDFInfo
- Publication number
- CN1116867C CN1116867C CN98112059A CN98112059A CN1116867C CN 1116867 C CN1116867 C CN 1116867C CN 98112059 A CN98112059 A CN 98112059A CN 98112059 A CN98112059 A CN 98112059A CN 1116867 C CN1116867 C CN 1116867C
- Authority
- CN
- China
- Prior art keywords
- ointment
- plastic bag
- rectum
- capsule
- vagina
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Landscapes
- Medicinal Preparation (AREA)
Abstract
The present invention belongs to the field of pharmacy. The existing suppository can not better meet the requirements of hardness and dissolution in vivo, and the suppository for a preparation of traditional Chinese medicine has the shortage of lacking medicine dosages; the existing microenema is a liquid preparation, and thus, the microenema can not be stably stored for the extract of the traditional Chinese medicine on the premise of sufficient medicine dosages. The existing ointment preparation has no preparation which has a disposable plastic capsule package and is used for being inserted into the rectum (or the vagina) for administration to reach the effect of clysis. An ointment of single dose of 2 to 20 ml, which is used for the rectum or the vagina, is packaged in a disposable plastic capsule for treating local diseases or systemic diseases.
Description
The present invention relates to pharmaceutical field.
The suppository of prior art is to be that the solid preparation that rectum, vagina are used is included in confession that substrate is made in cocoa butter or semi-synthetic fatty acid ester etc.Have following shortcoming: (1) existing substrate is softening in summer, is difficult to storage, is difficult to import rectum.(2) the medicine body is exposed in the air, unfavorable Long-term Storage.(3) because the requirement of medicine body hardness makes adjuvant select for use face narrow, bigger to volume especially Chinese drugs powder or extract are difficult to make suitable controlled release preparation.
Existing minisize liquid enema: it is the glycerin preparation that is used for relieving constipation that (1) Western medicine uses more at present.(2) suspension of the Chinese medicine extract of Chinese medicine use exists the appearance dose little, the shortcoming of poor stability.
Existing ointment: spread upon skin and mucosa delivery dosage form, but do not mould disposable heavy dose of (2ml-20ml) rectum of capsule packing or the ointment of vagina administration.
The objective of the invention is to make a kind of efficient, stable, pharmaceutical dosage form easily.
Medicine (Chinese medicine extract, ground product or medicinal chemicals) and adjuvant are made the ointment that suitable rectum (or vagina) absorbs.
With moulding the plastic bag of making according to the different 2-20ml of dosage, the about 0.5mm of wall thickness moulds the thin neck that capsule should have a 2-3cm length, so that administrations such as insertion rectum.The capsule body can be arbitrary shape.Mould capsule and generally should be opaque coloured plastics material, so that the content medicine reaches the purpose that keeps in Dark Place.
The ointment that makes injected mould capsule, sealing by fusing is standby, the time spent is cut off Nang Kou, inserts tract, the expulsion bladder body is clamp-oned in the body ointment.
The present invention is used to make the medicament of local diseases such as treatment rectum, vagina, also can be used for treating the medicament of general disease.
The present invention and suppository advantage relatively: (1) ointment is semi-solid preparation, with the easier absorption of solid preparation.(2) do not need to consider the hardness of medicine body, make the adjuvant range of choice wide in range, be easy to make various controlled release preparations.Larger volume for Chinese medicine extract also can hold.(3) the medicine body is closed in coloured capsule of moulding, and makes easy oxidation Decomposition and photosensitizer more stable.
Advantage with the comparison of minisize liquid enema: (1) has enlarged the adjuvant range of choice, more adapts to the needs of modern controlled release preparation, can be made into biologic adhesion preparation etc.(2) Chinese medicine minisize liquid enema is a kind of new formulation that grew up in recent years, generally be that tens gram to a few hectogram Chinese medicine extraction are made suspension about 5ml, seal standby, but because Chinese medicine ingredients complexity, especially in the compound preparation plurality of active ingredients is arranged, and invalid components can not be separated fully, make solid content contained in the medicinal liquid more, be difficult to stablize, turbidity and precipitation very easily takes place in storage.So never have shaped article, existing all is hospital preparation, interim preparation, storage period is extremely short, and make ointment type is Chinese medicine extraction to be concentrated back (or Chinese medicine fine powder) suitable substrate ointment and the adjuvant (surfactant, wetting agent, antiseptic etc.) of adding make ointment, can be semisolid because of the medicine body like this, and it is bigger to hold dose, more stable than existing liquid micro enema, use also convenient.
Advantage with the ointment comparison: this product is a kind of new application of ointment, present ointment is the aluminum pipe packing, smear the goods of skin and mucosa, the disposable rectum of capsule packing or the ointment formulation of vagina administration moulded of no use is in particular for the rectum absorption-type ointment of treatment general disease.
But the best way that realizes this patent is applied to Chinese medicine extract prepares the industrialization preparation of various Long-term Storage according to clinical needs, also can transform existing Western medicine suppository, makes it more convenient use, prolongs storage-life, realizes the controlled release purpose.
Claims (3)
1. mould the soft suppository of capsule for one kind, it is made up of with ointment and plastic bag pastille rectum or vagina, it is characterized in that plastic bag wherein has the long thin neck of a 2-3cm, capsule is as arbitrary shape, plastic bag wall thickness 0.5mm, plastic bag are opaque colored plastics, and the capacity of plastic bag is 2-20ml.
2. according to the described soft suppository of capsule of moulding of claim 1, it is characterized in that rectum or vagina contain medicinal chemicals, Chinese medicinal powder or extract with ointment.
3. claim 1 or 2 described preparation methoies of moulding the soft suppository of capsule, it is that medicine and adjuvant are made the ointment of suitable rectum or vagina absorption, plastic bag made of plastic, the thick 0.5mm of cyst wall, moulding capsule has the long thin neck of a 2-3cm, and capsule is as arbitrary shape, and the capacity of plastic bag is 2-20ml, with unit dose is that the rectum of 2-20ml or vagina inject the plastics softgel shell that has thin neck, sealing by fusing with ointment.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN98112059A CN1116867C (en) | 1998-06-08 | 1998-06-08 | Process for preparing ointment suppository contained in plastic bag |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN98112059A CN1116867C (en) | 1998-06-08 | 1998-06-08 | Process for preparing ointment suppository contained in plastic bag |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1238178A CN1238178A (en) | 1999-12-15 |
| CN1116867C true CN1116867C (en) | 2003-08-06 |
Family
ID=5221938
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN98112059A Expired - Fee Related CN1116867C (en) | 1998-06-08 | 1998-06-08 | Process for preparing ointment suppository contained in plastic bag |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1116867C (en) |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN2201953Y (en) * | 1994-07-30 | 1995-06-28 | 张瑞生 | Once-used vaginal remedies-introducing device |
| CN2213544Y (en) * | 1994-12-03 | 1995-11-29 | 鞍山钢铁公司 | Medicine supply apparatus of rectum suppository |
-
1998
- 1998-06-08 CN CN98112059A patent/CN1116867C/en not_active Expired - Fee Related
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN2201953Y (en) * | 1994-07-30 | 1995-06-28 | 张瑞生 | Once-used vaginal remedies-introducing device |
| CN2213544Y (en) * | 1994-12-03 | 1995-11-29 | 鞍山钢铁公司 | Medicine supply apparatus of rectum suppository |
Also Published As
| Publication number | Publication date |
|---|---|
| CN1238178A (en) | 1999-12-15 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN101474144B (en) | Tetracaine hydrochloride lipidosome gel and preparation method thereof | |
| CN102100894A (en) | Preparation technology of new integrative formulation of free wanderer powder and production method thereof | |
| CN102100899A (en) | Preparation technology of new integrative formulation of prepared common monkshood daughter root decoction for regulating middle | |
| CN1116867C (en) | Process for preparing ointment suppository contained in plastic bag | |
| CN102100813A (en) | Preparation technology of new integrative formulation of poria five powder and production method thereof | |
| CN101596300A (en) | Chinese medicine inducing resuscitation microemulsion nasal cavity spraying agent and preparation method thereof | |
| CN201814988U (en) | Chinese herbal medicine liquid-based external curer for preventing and curing multiple gynecological ovary and breast diseases | |
| CN2647347Y (en) | Carrier suppository for gynecology | |
| CN102283944A (en) | Technology for preparing novel integrated dosage form of lung heat expelling powder and production method thereof | |
| CN105343114A (en) | Medical application of verbascoside | |
| CN102188405A (en) | New cavity administration preparation formulation | |
| CN102895358A (en) | Preparation technology and production method for integrated new formulation of three-yellow decoction | |
| CN102100785A (en) | Preparation technique for xiao chengqi decoction in a novel formed formulation and production method thereof | |
| CN102283936A (en) | Integrated novel form preparation technology for Sisheng Wan and production method thereof | |
| CN102100756A (en) | Preparation technology of integrated rhubarb and aconite decoction novel dosage form | |
| CN210750557U (en) | Portable injection type enemator | |
| CN102846760A (en) | Preparation process of integration-type novel formulation of Cinnamomum cassia and Poria cocos decoction and production method thereof. | |
| CN102283901A (en) | Preparation technology and production method of integrated novel Jinsuo Gujing pill dosage form | |
| CN100463675C (en) | Soluble slow release external applied contraceptive | |
| CN201046298Y (en) | Thruster for female's vagina Qinggong capsule pill | |
| CN2210680Y (en) | Device for treating women's diseases of uterine neck and vagina | |
| CN2617362Y (en) | Suppository for vagina medicine feed | |
| CN1064850C (en) | Pile curing suppository ointment and its preparing method | |
| CN102526646A (en) | Preparation technology and production method of novel sweet osmanthus decoction integrated dosage form | |
| CN2347609Y (en) | Medicine feeder for vagina |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| C19 | Lapse of patent right due to non-payment of the annual fee | ||
| CF01 | Termination of patent right due to non-payment of annual fee |