CN111676133A

CN111676133A - Biomechanical driving system

Info

Publication number: CN111676133A
Application number: CN202010089755.9A
Authority: CN
Inventors: 林展翼; 文章
Original assignee: Guangdong General Hospital Guangdong Academy of Medical Sciences
Current assignee: Guangdong General Hospital Guangdong Academy of Medical Sciences
Priority date: 2020-02-12
Filing date: 2020-02-12
Publication date: 2020-09-18

Abstract

The invention relates to the technical field of driving equipment, and discloses a biomechanical driving system which comprises a shell, a sliding block, a sliding rail, a magnetic block, a magnetic adjusting module and a control module, wherein the sliding rail and the magnetic block are fixed on the shell, the sliding block is in sliding connection with the sliding rail, the sliding block is magnetic and is positioned in a magnetic field range, the magnetic adjusting module is positioned on the magnetic block, and the magnetic adjusting module is electrically connected with the control module. The control module transmits a control instruction to the magnetic adjusting module, the magnetic field generating electromagnetic force is controlled to push the sliding block to move along the sliding rail at different accelerated speeds, so that the sliding block provides different impulse pressure waveform pushing forces, the frequency of the magnetic field is controlled and converted, the purpose of adjusting the frequency and the pressure is achieved, very wide mechanical parameters are provided for adjustment, and the device can be more suitable for the biomechanical environment required by tubular organs.

Description

Biomechanical driving system

Technical Field

The invention relates to the technical field of driving equipment, in particular to a biomechanical driving system.

Background

In the field of tissue engineering, the mechanical environment has an important influence on the growth, tissue formation and reconstruction of tissue engineering seed cells. Stress-growth theory is central to tissue engineering applications for many organs. The culture of a tissue organ with functionalization in vitro is its ultimate goal. The three-dimensional culture environment of the cells comprises a biochemical environment and a physical environment. Among them, mechanical force stimulation plays a very central role in three-dimensional culture of cells. At present, a variety of bioreactors are available to provide the mechanical environment required by three-dimensional cell culture and play a certain role in promoting tissue formation. However, it is not known whether the mode of mechanical action (frequency, waveform, intensity) is really suitable for the culture of cells.

Stress-growth is one of the basic biomechanical theories proposed by the von nobel. The mechanical environment is an important stimulus factor for the development, growth and reconstruction of tissues and organs. The tissue engineering research of many organs requires the provision of specific and specific mechanical environments. In tubular organs, for example, in the case of vascular biomechanical studies, blood vessels are a very typical tissue with very complex mechanical properties. The current hemodynamics research is basically limited to two aspects of finite element analysis and G & R model establishment, and is difficult to simulate in an in-vitro near-physiological hemodynamics environment, and the in-vivo research is difficult to realize multi-aspect detection due to the limitation of detection means.

The current blood vessel tissue engineering dynamic loading driving device is based on a peristaltic pump or a pump with a similar working mode, the dynamic loading device with the working mode can only form a simple conventional sine waveform, and due to the limitation of the working mode, in order to have certain pressure, higher frequency is required to be adopted for three-dimensional culture of cells, so that the provided mechanical environment is far different from the physiological blood flow dynamic environment, the cultured blood vessel has certain mechanical properties such as tensile strength, but the anisotropy and the compliance are greatly different from those of a native blood vessel, and the application on the tissue engineering blood vessel is limited. In order to search for a more optimal mechanical culture environment, the mechanical parameters of the culture need to be adjusted. However, the power driving system based on the above working mode can only adjust the frequency, and the frequency adjusting range is small when the flow is adjusted by adjusting the frequency, and the frequency adjusting range is far higher than the range of the normal heart rate of a human body, so that the adjustable range of the pulsating pressure is very small. And the working mode of the peristaltic pump has the defects of serious vibration and heat generation and the like, and the risk of pipeline breakage exists after long-time operation.

Except blood vessels, other tubular organs have special biomechanical environments, and suitable mechanical driving platforms are needed for in vitro biomechanical research on the tubular organs, but the ideal in vitro mechanical driving platforms are lacked at present, so the research is greatly limited in the aspect.

Disclosure of Invention

The technical problem to be solved by the invention is as follows: how to provide a plurality of driving systems with adjustable mechanical parameters to adapt to the special biomechanical environment of the tubular organ.

In order to solve the technical problem, the invention provides a biomechanics driving system which comprises a shell, a sliding block, a sliding rail, a magnetic block, a magnetic adjusting module and a control module, wherein the sliding rail and the magnetic block are fixed on the shell, the sliding block is in sliding connection with the sliding rail, the sliding block is magnetic and is positioned in a range of a magnetic field formed after the magnetic block is electrified, the magnetic adjusting module is positioned on the magnetic block, and the magnetic adjusting module is electrically connected with the control module.

Preferably, the sliding block further comprises a pushing assembly arranged between the shell and the sliding block.

Preferably, the pushing assembly includes a piston and a cylinder, the piston is connected to the slider through a first fixing member, the cylinder is connected to the housing through a second fixing member, a connection port for connecting a piping system is provided at one end of the cylinder, and the piston is provided at the other end of the cylinder and has a degree of freedom of axial movement with respect to the cylinder to form a pushing force to enter and exit from the connection port.

As preferred scheme, first mounting includes fixed plate and fixing base, the fixing base is equipped with the fixed orifices, the fixing base is equipped with on the fixed plate, the fixing base is located and is used for installing the first semicircle groove of piston.

Preferably, the first fixing member further comprises a top seat arranged on the fixing seat, and the top seat is provided with a second semicircular groove opposite to the first semicircular groove.

Preferably, the fixing seat is provided with a first connecting hole, and the top seat is provided with a second connecting hole corresponding to the first connecting hole.

Preferably, the first semicircular groove is provided with a first positioning groove which is recessed along the radial direction, and the second semicircular groove is provided with a second positioning groove which is recessed along the radial direction and is opposite to the first positioning groove.

Preferably, the first positioning groove and the second positioning groove are both arc grooves.

Preferably, the number of the slide rails is two, one of the slide rails is located on one side of the slider, and the other slide rail is located on the other side of the slider.

Preferably, a buffer seat is arranged on the bottom surface of the shell.

Compared with the prior art, the biomechanics driving system provided by the invention has the beneficial effects that:

the control module transmits a control instruction to the magnetic adjusting module, the magnetic adjusting module enables the magnetic block to be electrified to generate electromagnetic force, the slider can be pushed to move along the sliding rail at different accelerated speeds by controlling the size of a magnetic field generating the electromagnetic force, so that the slider provides different impulse pressure waveform pushing forces, the frequency and the pressure can be adjusted by controlling the frequency of a switching magnetic field, the driving system can provide very wide mechanical parameters for adjustment, the mode and the range of mechanical loading are widened, the driving system can be more suitable for the biomechanical environment required by tubular organs, and the continuous long-time stable operation of the system can be ensured.

Drawings

Fig. 1 is a schematic view of the internal structure of a biomechanical drive system according to a preferred embodiment of the present invention.

Fig. 2 is a schematic top view of the biomechanical drive system of the preferred embodiment of the present invention.

Fig. 3 is a schematic structural view of a fixing plate and a fixing base in the biomechanical driving system according to the preferred embodiment of the present invention.

Fig. 4 is a schematic structural view of a top mount in the biomechanical drive system of the preferred embodiment of the present invention.

In the figure: 1. a housing; 2. a slider; 3. a slide rail; 4. a magnetic block; 5. a magnetic adjustment module; 6. a control module; 7. a piston; 8. a barrel; 9. a second fixing member; 10. a connecting port; 11. a fixing plate; 12. a fixed seat; 13. a fixing hole; 14. a first semicircular groove; 15. a top seat; 16. a second semi-circular groove; 17. a first connection hole; 18. a second connection hole; 19. a first positioning groove; 20. a second positioning groove; 21. a buffer seat.

Detailed Description

The following detailed description of embodiments of the present invention is provided in connection with the accompanying drawings and examples. The following examples are intended to illustrate the invention but are not intended to limit the scope of the invention.

In the description of the present invention, it should be noted that the terms "upper", "lower", "front", "rear", "left", "right", "vertical", "horizontal", "top", "bottom", "inner", "outer", etc. indicate orientations or positional relationships based on those shown in the drawings, and are only for convenience of description and simplicity of description, but do not indicate or imply that the referred device or element must have a specific orientation, be constructed and operated in a specific orientation, and thus, should not be construed as limiting the present invention.

In the description of the present invention, it should be understood that the terms "connected," "fixed," and the like are used in a broad sense, and for example, the terms "connected," "connected," and "fixed" may be fixed, detachable, or integrated; the connection can be mechanical connection or welding connection; they may be directly connected or indirectly connected through intervening media, or they may be connected internally or in any other suitable relationship, unless expressly stated otherwise. The specific meanings of the above terms in the present invention can be understood by those skilled in the art according to specific situations.

As shown in fig. 1 to 4, a preferred embodiment of the present invention provides a biomechanical driving system, which includes a housing 1, a slider 2, a sliding rail 3, a magnetic block 4, a magnetic adjustment module 5, and a control module 6, wherein the sliding rail 3 and the magnetic block 4 are fixed on the housing 1, the slider 2 is slidably connected to the sliding rail 3, the slider 2 has magnetism and is located in a range of a magnetic field formed by energizing the magnetic block 4, the magnetic adjustment module 5 is located on the magnetic block 4, and the magnetic adjustment module 5 is electrically connected to the control module 6.

Based on the biomechanics actuating system of above-mentioned technical characteristics, through control module 6 transmission control command to on the magnetism adjusting module 5, magnetism adjusting module 5 makes magnetic path 4 circular telegram and produce the electromagnetic force, and the accessible control produces the magnetic field size of electromagnetic force, with different accelerations promote slider 2 moves along slide rail 3, thereby make slider 2 provides the thrust of different pulsation pressure wave forms, and the frequency of accessible control switching magnetic field realizes the purpose of adjustable frequency and pressure, and this actuating system can provide very wide mechanical parameter and adjust, has widened the modal and the scope of mechanics loading, more can adapt to the required biomechanics environment of tubular organ, and can guarantee that the system is long-time steady operation in succession.

In this embodiment, the device further comprises a pushing assembly arranged between the shell 1 and the sliding block 2, and the pushing assembly converts the moving thrust generated by the sliding block 2 into other thrust to act on the flowing medium of the tubular organ.

In this embodiment, the pushing assembly includes a piston 7 and a cylinder 8, the piston 7 is connected to the slider 2 through a first fixing member, the cylinder 8 is connected to the housing 1 through a second fixing member 9, a connection port 10 for connecting a piping system (e.g., a front end diaphragm pump piping system) is provided at one end of the cylinder 8, the piston 7 is provided at the other end of the cylinder 8 and has a degree of freedom of axial movement with respect to the cylinder 8 to form an air thrust that enters and exits from the connection port 10, the cylinder 8 is fixed with respect to the housing 1, and the air thrust is formed by movement of the piston 7 with respect to the cylinder 8 and acts on the tubular air tube, so that a multi-stage movement stroke of the piston 7 can be adjusted according to user settings, thereby adjusting a pressure waveform forming the thrust.

Further, as shown in fig. 3, the first fixing member includes a fixing plate 11 and a fixing seat 12, the fixing seat 12 is provided with a fixing hole 13, the fixing seat 12 is provided on the fixing plate 11, the fixing seat 12 is provided in a first semicircular groove 14 for installing the piston 7, the fixing plate 11 is provided with a fixing hole 13, and is installed on the slider 2 through a bolt, the fixing seat 12 is provided on the fixing plate 11, and the piston 7 is installed in the first semicircular groove 14, so that the piston 7 is installed.

Further, as shown in fig. 4, the first fixing element further includes a top seat 15 disposed on the fixing seat 12, the top seat 15 is provided with a second semicircular groove 16 disposed opposite to the first semicircular groove 14, and the top seat 15 is fixed on the fixing seat 12, so that the first semicircular groove 14 and the second semicircular groove 16 form a clamping position for the piston 7, and are tightly matched to further achieve a stabilizing effect. The fixed seat 12 is provided with a first connecting hole 17, the top seat 15 is provided with a second connecting hole 18 corresponding to the first connecting hole 17, and the fixed seat 12 is connected with the top seat 15 by a bolt passing through the first connecting hole 17 and the second connecting hole 18.

Still further, the first semicircular groove 14 is provided with a first positioning groove 19 recessed along the radial direction, the second semicircular groove 16 is provided with a second positioning groove 20 recessed along the radial direction and arranged opposite to the first positioning groove 19, and the first positioning groove 19 and the second positioning groove 20 play a limiting role, so that the sliding block 2 drives the piston 7 to move synchronously in the moving process. Specifically, first constant head tank 19 with second constant head tank 20 is the circular arc groove, piston 7 be equipped with the corresponding circular arc arch in circular arc groove is convenient for can fix a position during the installation fast piston 7 can accurate control on the circular arc groove piston 7's motion, guarantee piston 7 with the simultaneous movement of slider 2.

In this embodiment, the quantity of slide rail 3 is two, one of them slide rail 3 is located one side of slider 2, another slide rail 3 is located the opposite side of slider 2, two slide rail 3 is symmetrical arrangement, can prevent that the thrust from fluctuating too greatly, maintains fluctuation in a little error range, guarantees operating stability. The slide rail 3 is a linear guide rail, has no gear transmission structure, belongs to a direct drive mode, has no loss of transmission mechanical energy, can reduce the heat loss to the minimum, runs stably, can run continuously for a long time, and only needs normal natural air for heat dissipation. And because the direct driving mode is adopted, the slide block 2 moves in a large acceleration state in a short time, and the slide block 2 provides high-precision instantaneous large thrust for a pipeline system.

In this embodiment, the bottom surface of the housing 1 is provided with the buffer seat 21, which has a buffering effect on the vibration of the whole system in a high-speed, high-frequency and continuous motion state, and the buffer seat 21 has a better friction force through an anti-skid design, so that the system can be prevented from generating displacement on a smooth table surface in a high-speed operation state, and the stable operation of the whole system is ensured.

In addition, the control module 6 can execute a computer instruction connected with the control module 6 through an existing PLC controller or a single chip microcomputer controller, the computer is connected with the control module 6 through a USB interface 232 interface, and transmits a control signal to the magnetic adjustment module 5 to adjust parameters such as current magnitude, which belongs to open source control, and can automatically control the motion mode of the slider 2 according to the requirement, thereby controlling the generated pressure mode, and realizing motion control of the slider 2 through a programmed program. In order to ensure that the slider 2 is driven to have enough stroke, the number of the magnetic blocks 4 can be set to be multiple, each magnetic block 4 is provided with a corresponding magnetic adjusting module 5 to realize independent control, and the slider 2 is controlled to have the advantages of long stroke, instantaneous high thrust and the like.

The invention aims to provide a biomechanics driving system utilizing an electromagnetic guide rail type, which can select pressure and adjust frequency or select frequency and adjust pressure simultaneously to achieve the aim of providing different pulsating pressure waveforms, and the pressure waveforms can be automatically set by a user through programming control to realize the control of a thrust mode. The driving system has wide application on fluid media, can be used for gas, liquid with different viscosities and blood, and has the advantages of simple use, stable operation and compact structure. The transmission mode and the structure meet the requirements of small mechanical loss and heat loss, almost no vibration and noise are generated, and long-time loading and stable operation of a mechanical environment can be met. Under low power operation, can be used for laboratory research; under the operation of high power, the requirement of tubular organ tissue engineering industrialization can be met, and the mass production is carried out.

To sum up, the biomechanical driving system provided by the embodiment of the present invention has the following advantages: (1) the method breaks through the limitation of the prior art on the selection of the pulsating fluid mechanics loading mode and parameters, can provide very wide mechanics parameters for adjustment, comprises two parameters of independent frequency and pressure, can set, adjust and explore various mechanics loading modes for the biomechanics and the dynamics environment of tubular organs, and can adjust the multi-section motion stroke of the piston 7 according to the setting of a user by utilizing the open source control of the parameters, thereby adjusting the pressure waveform of the generated thrust. (2) The electromagnetic driving type hydraulic control system is simple in structure, low in manufacturing cost, compact in structural design, stable in system operation, capable of being directly driven in an electromagnetic driving mode, capable of reducing mechanical transmission of parts in a working state and small in mechanical energy loss and heat loss. (3) The motion precision is high, the high-precision instantaneous large thrust can be provided, the condition of natural air cooling can be met due to almost no mechanical energy loss, the running power can be freely adjusted, and the peak thrust under high power can reach the industrial level.

The foregoing is only a preferred embodiment of the present invention, and it should be noted that, for those skilled in the art, various modifications and substitutions can be made without departing from the technical principle of the present invention, and these modifications and substitutions should also be regarded as the protection scope of the present invention.

Claims

1. The biomechanical driving system is characterized by comprising a shell, a sliding block, a sliding rail, a magnetic block, a magnetic adjusting module and a control module, wherein the sliding rail and the magnetic block are fixed on the shell, the sliding block is in sliding connection with the sliding rail, the sliding block is magnetic and is located in the range of a magnetic field formed after the magnetic block is electrified, the magnetic adjusting module is located on the magnetic block, and the magnetic adjusting module is electrically connected with the control module.

2. The biomechanical drive system of claim 1, further comprising a pushing assembly disposed between said housing and said slide.

3. The biomechanical drive system of claim 2, wherein said pushing assembly comprises a piston and a cylinder, said piston is connected to said slider by a first fastener, said cylinder is connected to said housing by a second fastener, one end of said cylinder is provided with a connection port for connecting a tubing system, said piston is provided at the other end of said cylinder and has freedom to move axially relative to said cylinder to form a pushing force in and out of said connection port.

4. The biomechanical drive system of claim 3, wherein the first fastener comprises a fixed plate and a fixed seat, the fixed seat is provided with a fixed hole, the fixed seat is provided on the fixed plate, and the fixed seat is provided on the first semicircular groove for mounting the piston.

5. The biomechanical drive system of claim 4, wherein said first fastener further comprises a top seat disposed on said anchor seat, said top seat having a second semi-circular slot disposed opposite said first semi-circular slot.

6. The biomechanical drive system of claim 5, wherein said anchor base is provided with a first attachment hole and said top base is provided with a second attachment hole corresponding to said first attachment hole.

7. The biomechanical drive system of claim 5, wherein said first slot defines a first detent recessed along a radial direction and said second slot defines a second detent recessed along a radial direction and disposed opposite said first detent.

8. The biomechanical drive system of claim 7, wherein said first detent and said second detent are both arcuate grooves.

9. The biomechanical drive system of any of claims 1 through 8, wherein said slide rails are two in number, one on one side of said slide and the other on the other side of said slide.

10. The biomechanical drive system of any of claims 1 through 8, wherein a bottom surface of said housing is provided with a cushioned seat.