CN111671834A - Rheumatism bone pain tincture and preparation method thereof - Google Patents

Rheumatism bone pain tincture and preparation method thereof Download PDF

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CN111671834A
CN111671834A CN202010755574.5A CN202010755574A CN111671834A CN 111671834 A CN111671834 A CN 111671834A CN 202010755574 A CN202010755574 A CN 202010755574A CN 111671834 A CN111671834 A CN 111671834A
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bone pain
tincture
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成建荣
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/26—Aristolochiaceae (Birthwort family), e.g. heartleaf
    • A61K36/268—Asarum (wild ginger)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/67—Piperaceae (Pepper family), e.g. Jamaican pepper or kava
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/70—Polygonaceae (Buckwheat family), e.g. spineflower or dock
    • A61K36/704—Polygonum, e.g. knotweed
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/70—Polygonaceae (Buckwheat family), e.g. spineflower or dock
    • A61K36/708—Rheum (rhubarb)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/75—Rutaceae (Rue family)
    • A61K36/758—Zanthoxylum, e.g. pricklyash
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/888—Araceae (Arum family), e.g. caladium, calla lily or skunk cabbage
    • A61K36/8884—Arisaema, e.g. Jack in the pulpit
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH

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Abstract

A rheumatic ostealgia tincture and a preparation method thereof relate to the technical field of medicine preparation. The rheumatism bone pain tincture is prepared from the following raw materials: radix Aconiti, radix Aconiti Kusnezoffii, lignum sappan, radix Notoginseng, radix et rhizoma Rhei, flos Rhododendri mollis, fructus Zanthoxyli, fructus Piperis Longi, rhizoma arisaematis, and herba asari. The rheumatism bone pain tincture can be prepared by taking a proper amount of raw materials according to a preparation method of the rheumatism bone pain tincture. After the technical scheme is adopted, the invention has the beneficial effects that: the traditional Chinese medicine composition can effectively relieve rheumatic bone pain, has good drug effect and comfortable use, is mild in taste and free from stimulation, can make a human body comfortable in a short treatment course, and gets rid of the trouble of rheumatic bone pain; the preparation method is simple, the preparation procedures are few, the working hours required by preparation are short, and the method is suitable for batch production.

Description

Rheumatism bone pain tincture and preparation method thereof
Technical Field
The invention relates to the technical field of medicine preparation, in particular to a rheumatic bone pain tincture and a preparation method thereof.
Background
The rheumatism bone disease is caused by invasion of wind-cold-dampness pathogen into human body, and after the wind-cold-dampness pathogen invades the human body, the tendons and vessels are blocked and the obstruction leads to pain, thereby red swelling and pain are caused at the joints, periosteum, muscles and other parts of the human body. The treatment method for the rheumatic bone pain comprises western medicine treatment for relieving pain, physical treatment, massage and acupuncture treatment, closed therapy, operation treatment and the like, but the methods have many defects, some have large side effect and high cost, and some treatments cause patients to suffer pain and have intolerable pain. When treating rheumatic ostealgia, the treatment can be carried out by adopting physical therapy methods such as local thermotherapy, hot water bath, steam therapy and the like, and can also be carried out by adopting drug treatment methods such as oral administration, external application and the like.
Most of the existing liquid tinctures for treating rheumatic bone pain have strong irritation and low use comfort, have poor drug effect on treating rheumatic bone pain, and can relieve pain by a long treatment process; the existing preparation method for the rheumatic bone pain tincture is complex, has more preparation procedures, needs longer working hours and is not suitable for batch production.
Disclosure of Invention
The invention aims to provide the rheumatic bone pain tincture and the preparation method thereof aiming at the defects and the defects of the prior art, the rheumatic bone pain tincture can effectively relieve the rheumatic bone pain, has good drug effect and comfortable use feeling, is mild in taste and free from stimulation, can make a human body comfortable in a short treatment course, and gets rid of the trouble of the rheumatic bone pain; the preparation method is simple, the preparation procedures are fewer, the working hours required by preparation are short, and the method is suitable for batch production; the rheumatic bone pain tincture is also suitable for traumatic injuries and innominate swelling and pain.
In order to achieve the purpose, the invention adopts the following technical scheme:
the rheumatism bone pain tincture is prepared from the following raw materials in parts by weight: 10-15 parts of raw radix aconiti, 10-15 parts of raw radix aconiti kusnezoffii, 10-20 parts of sappan wood, 10-15 parts of panax notoginseng, 10-15 parts of raw rhubarb, 2-5 parts of rhododendron molle, 10-15 parts of pericarpium zanthoxyli, 10-15 parts of piper longum, 10-15 parts of raw arisaema and 10-20 parts of asarum;
the preparation method comprises the following steps: a. taking a proper amount of raw materials, mixing and grinding the raw materials into fine powder; b. taking a container filled with the white spirit, soaking the mixed powder in the container, and soaking; c. filtering the soaked mixed liquid, precipitating the residue, and extracting the liquid medicine; d. removing the filtered clear liquid medicine, fully and uniformly stirring, filling and packaging to obtain a finished product.
The grinding unit of the fine powder is 120 meshes. The thinner the medicinal powder is, the more the medicinal powder can be fully mixed with the white spirit, and the drug effect is improved.
The alcohol content of the white spirit is 50 degrees, and the container filled with the white spirit with 50 degrees is an aseptic container.
The soaking time is one month.
The stirring is divided into two stages, namely primary stirring and fine stirring; the primary stirring time is 10-15 minutes, and the fine stirring time is 30-40 minutes.
After the technical scheme is adopted, the invention has the beneficial effects that: the traditional Chinese medicine composition can effectively relieve rheumatic bone pain, has good drug effect and comfortable use, is mild in taste and free from stimulation, can make a human body comfortable in a short treatment course, and gets rid of the trouble of rheumatic bone pain; the preparation method is simple, the preparation procedures are few, the working hours required by preparation are short, and the method is suitable for batch production. The rheumatic bone pain tincture is also suitable for traumatic injuries and innominate swelling and pain.
Detailed Description
Implement one
The technical scheme adopted by the specific implementation mode is as follows: the rheumatism bone pain tincture is prepared from the following raw materials in parts by weight: 10 parts of raw radix aconiti, 10 parts of raw radix aconiti kusnezoffii, 10 parts of sappan wood, 10 parts of panax notoginseng, 10 parts of raw rhubarb, 2 parts of rhododendron molle, 10 parts of pericarpium zanthoxyli, 10 parts of piper longum, 10 parts of raw rhizoma arisaematis and 10 parts of asarum;
the preparation method comprises the following steps: a. taking a proper amount of raw materials, mixing and grinding the raw materials into fine powder; b. taking a container filled with the white spirit, soaking the mixed powder in the container, and soaking; c. filtering the soaked mixed liquid, precipitating the residue, and extracting the liquid medicine; d. removing the filtered clear liquid medicine, fully and uniformly stirring, filling and packaging to obtain a finished product.
The grinding unit of the fine powder is 120 meshes. The thinner the medicinal powder is, the more the medicinal powder can be fully mixed with the white spirit, and the drug effect is improved.
The alcohol content of the white spirit is 50 degrees, and the container filled with the white spirit with 50 degrees is an aseptic container.
The soaking time is one month.
The stirring is divided into two stages, namely primary stirring and fine stirring; the primary stirring time is 10-15 minutes, and the fine stirring time is 30-40 minutes.
The unprocessed radix aconiti is in an irregular conical shape, is slightly bent, has a residual stem at the top end, is expanded to one side of the middle part in multiple directions, is 2-7.5 cm long and is 1.2-2.5 cm in diameter. The surface is dark brown or gray brown, and has wrinkles and traces of small tumor-shaped lateral roots and sub-roots after detachment. Firm, white or light gray yellow cross section, polygonal ring lines of the formed layer. Light smell, pungent and numb taste; dispel wind and dampness, warm meridians and alleviate pain. Can be used for treating arthralgia due to wind-cold-dampness, arthralgia, psychroalgia of heart and abdomen, cold hernia, and pain due to anesthesia.
Raw kusnezoff monkshood root, the name of traditional Chinese medicine. Is root tuber of Aconitum carmichaeli (wild species) or Aconitum kusnezoffii (Aconitum kusnezoffii) belonging to Ranunculaceae. Collected in autumn when stem and leaf withered, removed fibrous root and silt, and dried. The wild aconite used in the market at present is a wild product, and the northern area of China is mainly taken from the aconitum kusnezoffii of Ranunculaceae, and the southern area is mainly taken from the tuberous root of the aconitum kusnezoffii kusne. Has the effects of expelling wind and removing dampness, warming channel and expelling cold, and relieving swelling and pain.
Lignum sappan is dried heartwood of lignum sappan of Caesalpiniaceae. The functional indications are as follows: promoting blood circulation, removing blood stasis, relieving swelling and pain. It is used to treat blood, qi, heart and abdominal pain, amenorrhea, postpartum distending pain and dyspnea due to blood stasis, dysentery, tetanus, carbuncle and swelling, and pain due to blood stasis and stagnation.
Xueqi has the functions of promoting blood circulation to restore menstrual flow, promoting qi circulation to dissipate blood stasis, stopping bleeding and relieving pain. It can be used for treating traumatic hemorrhage, traumatic injury, overstrain, menoxenia, skin ulcer, and furuncle.
The raw rhubarb is the decoction pieces of the original medicinal materials. Has the main functions of removing food retention and relieving constipation, and is used for treating excess heat in stomach and intestine and constipation.
The raw arisaema tuber has the functions of drying dampness and resolving phlegm, dispelling wind and relieving spasm, and resolving masses and eliminating swelling. Can be used for treating intractable phlegm cough, wind phlegm giddiness, apoplexy, facial distortion, hemiplegia, epilepsy, infantile convulsion, and tetanus. Unprocessed for treating abscess and swelling, snake and insect bites.
The herba asari has effects of dispelling pathogenic wind, dispelling cold, promoting diuresis, and inducing resuscitation. And has the functions of treating wind cold headache, nasosinusitis, toothache, phlegm and fluid retention cough, rheumatism, etc.
Example two
The difference between this embodiment and the first embodiment is: the rheumatism bone pain tincture is prepared from the following raw materials in parts by weight: 12 parts of raw radix aconiti, 12 parts of raw radix aconiti kusnezoffii, 15 parts of sappan wood, 12 parts of panax notoginseng, 12 parts of raw rhubarb, 4 parts of rhododendron molle, 12 parts of pericarpium zanthoxyli, 12 parts of long pepper, 12 parts of raw arisaema tuber and 15 parts of asarum;
the composition and preparation method of other raw materials are the same as those in the first embodiment.
EXAMPLE III
The difference between this embodiment and the first embodiment is: the rheumatism bone pain tincture is prepared from the following raw materials in parts by weight: 15 parts of raw radix aconiti, 15 parts of raw radix aconiti kusnezoffii, 20 parts of sappan wood, 15 parts of panax notoginseng, 15 parts of raw rhubarb, 5 parts of rhododendron molle, 15 parts of pericarpium zanthoxyli, 15 parts of piper longum, 15 parts of raw rhizoma arisaematis and 20 parts of asarum;
the composition and preparation method of other raw materials are the same as those in the first embodiment.
After the technical scheme is adopted, the invention has the beneficial effects that: the traditional Chinese medicine composition can effectively relieve rheumatic bone pain, has good drug effect and comfortable use, is mild in taste and free from stimulation, can make a human body comfortable in a short treatment course, and gets rid of the trouble of rheumatic bone pain; the preparation method is simple, the preparation procedures are fewer, the working hours required by preparation are short, and the method is suitable for batch production; the rheumatic bone pain tincture is also suitable for traumatic injuries and innominate swelling and pain.
The above description is only for the purpose of illustrating the technical solutions of the present invention and not for the purpose of limiting the same, and other modifications or equivalent substitutions made by those skilled in the art to the technical solutions of the present invention should be covered within the scope of the claims of the present invention without departing from the spirit and scope of the technical solutions of the present invention.

Claims (9)

1. The rheumatism bone pain tincture is characterized by comprising the following raw materials in parts by weight: 10-15 parts of unprocessed radix aconiti, 10-15 parts of unprocessed radix aconiti kusnezoffii, 10-20 parts of sappan wood, 10-15 parts of panax notoginseng, 10-15 parts of unprocessed rheum officinale, 2-5 parts of rhododendron molle, 10-15 parts of pericarpium zanthoxyli, 10-15 parts of piper longum, 10-15 parts of unprocessed rhizoma arisaematis and 10-20 parts of asarum.
2. The preparation method of the rheumatic bone pain tincture is characterized by comprising the following steps: a. taking a proper amount of raw materials, mixing and grinding the raw materials into fine powder; b. taking a container filled with the white spirit, soaking the mixed powder in the container, and soaking; c. filtering the soaked mixed liquid, precipitating the residue, and extracting the liquid medicine; d. removing the filtered clear liquid medicine, fully and uniformly stirring, filling and packaging to obtain a finished product.
3. The rheumatic bone pain tincture of claim 1, wherein the external use of the external application comprises: the composite material consists of the following raw materials in parts by weight: 10 parts of unprocessed radix aconiti, 10 parts of unprocessed radix aconiti kusnezoffii, 10 parts of sappan wood, 10 parts of panax notoginseng, 10 parts of unprocessed rheum officinale, 2 parts of rhododendron molle, 10 parts of pericarpium zanthoxyli, 10 parts of piper longum, 10 parts of unprocessed rhizoma arisaematis and 10 parts of asarum.
4. The rheumatic bone pain tincture of claim 1, wherein the external use of the external application comprises: the composite material consists of the following raw materials in parts by weight: 12 parts of raw common monkshood mother root, 12 parts of raw kusnezoff monkshood root, 15 parts of sappan wood, 12 parts of hemsleya root, 12 parts of raw rhubarb, 4 parts of Chinese azalea flower, 12 parts of pericarpium zanthoxyli, 12 parts of long pepper, 12 parts of raw arisaema tuber and 15 parts of manchurian wildginger.
5. The rheumatic bone pain tincture of claim 1, wherein the external use of the external application comprises: the composite material consists of the following raw materials in parts by weight: 15 parts of raw common monkshood mother root, 15 parts of raw kusnezoff monkshood root, 20 parts of sappan wood, 15 parts of hemsleya root, 15 parts of raw rhubarb, 5 parts of Chinese azalea flower, 15 parts of pericarpium zanthoxyli, 15 parts of long pepper, 15 parts of raw arisaema tuber and 20 parts of manchurian wildginger.
6. The method for preparing the rheumatic bone pain tincture, according to the claim 2, is characterized in that: the grinding unit of the fine powder is 120 meshes.
7. The method for preparing the rheumatic bone pain tincture, according to the claim 2, is characterized in that: the alcohol content of the white spirit is 50 degrees.
8. The method for preparing the rheumatic bone pain tincture, according to the claim 2, is characterized in that: the soaking time is one month.
9. The method for preparing the rheumatic bone pain tincture, according to the claim 2, is characterized in that: the stirring is divided into two stages, namely primary stirring and fine stirring; the primary stirring time is 10-15 minutes, and the fine stirring time is 30-40 minutes.
CN202010755574.5A 2020-07-31 2020-07-31 Rheumatism bone pain tincture and preparation method thereof Pending CN111671834A (en)

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Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109394927A (en) * 2018-11-24 2019-03-01 河南百笑堂生物科技有限公司 A kind of external-use analgesic liquid and preparation method thereof

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109394927A (en) * 2018-11-24 2019-03-01 河南百笑堂生物科技有限公司 A kind of external-use analgesic liquid and preparation method thereof

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