CN111671803A

CN111671803A - Medicament for treating scald and preparation method thereof

Info

Publication number: CN111671803A
Application number: CN202010619807.9A
Authority: CN
Inventors: 梁东
Original assignee: Individual
Current assignee: Individual
Priority date: 2020-07-01
Filing date: 2020-07-01
Publication date: 2020-09-18

Abstract

The invention discloses a medicament for treating scalds and a preparation method thereof, wherein the medicament is prepared from the following raw materials in parts by weight: 90-110 g of Chinese teasel, 8-12 g of pawpaw, 120-170 g of river pearl and 40-60 g of boy urine; the invention specifically combines the raw materials according to the traditional Chinese medicine characteristics of the raw materials and the effective components of the raw materials, limits the dosage of the raw materials, can promote the drug effect of the raw materials to be fully exerted, effectively reduces the inflammation on the surface of a scald wound through the synergistic effect of the drug effects of the raw materials, inhibits bacterial infection, promotes the microcirculation on the surface of the wound, accelerates the blood circulation, achieves the aim of quickly repairing skin tissues under sufficient nutrient substances, and has no scars after treatment.

Description

Medicament for treating scald and preparation method thereof

Technical Field

The invention relates to the technical field of scald medicines, in particular to a medicament for treating scald and a preparation method thereof.

Background

Burn generally refers to the thermal damage of tissues caused by hot liquid (water, soup, oil, etc.), steam, high temperature gas, flame, hot metal liquid or solid (such as molten steel, steel ingot), mainly refers to skin and/or mucous membrane, and serious patients may also injure subcutaneous or/and submucosal tissues, such as muscle, bone, joint and even viscera. Scald is a tissue injury caused by hot liquid, steam, etc., and is a kind of thermal burn.

At present, aiming at the treatment of burn, western medicine mainly adopts antibiotic medicines for treatment, and most of traditional Chinese medicines are treated by coptis chinensis ointment, jiuyidan and other medicines, however, the treatment time is long and scars exist.

Disclosure of Invention

Aiming at the defects in the prior art, the invention provides a medicament for treating scalds, which can relieve pain and itching, promote blood circulation and generation of skin tissues, quickly repair burn tissues and leave no scars on the wound surfaces after treatment.

In order to achieve the above purpose of the present invention, the following technical solutions are adopted:

the invention provides a medicament for treating scalds, which is prepared from the following raw materials in parts by weight:

90-110 g of Chinese teasel, 8-12 g of pawpaw, 120-170 g of river pearl and 40-60 g of boy urine.

The Chinese medicinal materials are specifically combined according to the characteristics of the Chinese medicinal materials and the effective components of the Chinese medicinal materials, the dosage of the Chinese medicinal materials is limited, the drug effect of the Chinese medicinal materials can be fully exerted, specifically, the fresh water river pearl can provide amino acid for skin tissues, can resist inflammation and reduce swelling, dredge microcirculation on the surface of a wound and promote skin repair, the pawpaw has the effects of inhibiting bacteria, relaxing muscles and tendons, activating blood circulation, eliminating dampness and reducing swelling, the Chinese fevervine fruit has the effects of clearing heat and removing toxicity, stopping bleeding and reducing swelling, the urine of boys serves as a guiding drug, the drug effect of each raw material can be increased, the inflammation on the surface of a scald wound is effectively reduced through the synergistic effect of the drug effects of the raw materials, the bacterial infection is inhibited, the microcirculation on the surface of the wound is promoted, the blood circulation is accelerated, the aim of quickly repairing the skin.

Preferably, the medicament is prepared from the following raw materials in parts by weight:

100g of Chinese fevervine herb, 10g of pawpaw, 150g of river pearl and 50g of boy urine.

Through the selection of the specific dosage of each raw material, the interaction among the raw materials can be better promoted, and the overall efficacy of the preparation is improved.

Preferably, the raw materials further comprise:

90-110 g of hemp and millet.

Preferably, the hemp grain is 100 g.

The hemp grain has the functions of relieving pain and itching and promoting blood circulation, and can play the roles of relieving pain and itching, quickening the blood circulation of wound tissues and promoting the tissue repair by adding the hemp grain and externally applying the hemp grain to the surface of the wound.

Preferably, the particle size of the river pearl is not less than 300 meshes; preferably 300-500 meshes; by limiting the particle size of the river pearl, the precipitation of effective components in the river pearl can be promoted, and the absorption of wound tissues is facilitated.

In a second aspect, the present invention provides a method for preparing the above medicament, the method comprising the steps of:

mixing the raw materials uniformly according to the weight part ratio to obtain a mixture;

and (3) putting the mixture into water for decoction and concentration to obtain the medicament.

By decocting the raw materials, effective ingredients in the raw materials can be effectively extracted, and the overall efficacy of the preparation is improved.

Preferably, the method further comprises the following steps:

dissolving fructus Cannabis in the concentrated solution.

The hemp and millet are directly added into the concentrated solution, so that the hemp and millet can be prevented from reacting with active ingredients in other raw materials in the decocting process, the content of the active ingredients is reduced, and the effect of the prepared medicament is influenced.

Preferably, the boiling time is 1-2 h.

Preferably, the concentration is to concentrate the decocted solution to a relative density of 1.2-1.4 at 30 ℃.

The decocted solution is concentrated, so that the content of effective components in the prepared medicament is ensured, the repair of skin tissues can be better promoted under the content, and the wound healing is promoted without scars.

Preferably, the preparation method further comprises:

before the raw materials are mixed uniformly, the Chinese teasel, the pawpaw and the pearl are respectively crushed;

the Chinese teasel is crushed to have the particle size of 0.1-0.5 mm; the pawpaw and the pearl powder are crushed to the granularity of more than 300 meshes.

The invention has the beneficial effects that:

Detailed Description

The following describes embodiments of the present invention in detail. The following examples are only for illustrating the technical solutions of the present invention more clearly, and therefore are only examples, and the protection scope of the present invention is not limited thereby.

It is to be noted that, unless otherwise specified, technical or scientific terms used herein shall have the ordinary meaning as understood by those skilled in the art to which the invention pertains.

Example 1

Medicament for treating scald

The medicament for treating the scald is prepared from the following raw materials in parts by weight:

90g of Chinese fevervine herb, 12g of pawpaw, 120g of river pearl and 60g of boy urine.

Second, preparation method

The preparation method of the medicament for treating the scalds comprises the following steps:

crushing the Chinese redwood into particles with the particle size of 0.1-0.5 mm, and crushing the pawpaw and the pearl powder into particles with the particle size of 300-400 meshes;

mixing urine of boys with pulverized herba Ranunculi Japonici, fructus Chaenomelis and Margarita powder to obtain mixture;

decocting the mixture in 2500g of water for 1h, and concentrating the decocted solution to relative density of 1.24 at 30 deg.C to obtain the preparation for treating scald.

Example 2

Medicament for treating scald

110g of Chinese fevervine herb, 8g of pawpaw, 170g of river pearl and 40g of boy urine.

Second, preparation method

crushing the Chinese redwood into particles with the particle size of 0.1-0.5 mm, and crushing the pawpaw and the pearl powder into particles with the particle size of 400-500 meshes;

decocting the mixture in 2200g water for 2h, and concentrating the decoction solution to relative density of 1.36 at 30 deg.C to obtain the preparation for treating scald.

Example 3

Medicament for treating scald

Second, preparation method

crushing the Chinese redwood into particles with the particle size of 0.1-0.5 mm, and crushing the pawpaw and the pearl powder to the particle size of 350-450 meshes;

decocting the mixture in 2000g water for 2h, and concentrating the decoction solution to relative density of 1.32 at 30 deg.C to obtain the preparation for treating scald.

Example 4

Medicament for treating scald

100g of hemp grain, 100g of Chinese fevervine herb, 10g of pawpaw, 150g of river pearl and 50g of boy urine.

Second, preparation method

placing the mixture into 2000g of water for decocting for 2h, and then concentrating the decocted solution until the relative density of the solution is 1.32 at 30 ℃;

dissolving fructus Cannabis in the concentrated solution to obtain the preparation for treating scald.

Example 5

Medicament for treating scald

110g of hemp grain, 100g of Chinese fevervine herb, 10g of pawpaw, 160g of river pearl and 45g of boy urine.

Second, preparation method

placing the mixture into 2000g of water for decocting for 2h, and then concentrating the decocted solution until the relative density of the solution is 1.24 at 30 ℃;

Comparative example 1

The comparative example is a medicament for treating scalds, which is basically the same as the medicament for treating scalds in example 3, and is different only in that river pearls are replaced by seawater pearls with the same fraction;

the preparation method of the medicament for treating the scald is the same as that in the embodiment 3.

Comparative example 2

The comparative example is a medicament for treating scalds, which is basically the same as the medicament for treating scalds in example 3, and is different only in that urine of children is replaced by the Chinese goosebeery herb with the same fraction;

Comparative example 3

The comparative example is a medicament for treating scalds, which is prepared from the following raw materials in parts by weight:

70g of Chinese teasel, 20g of pawpaw, 100g of river pearl and 30g of boy urine;

Comparative example 4

The comparative example is a medicament for treating scalds, and the medicament for treating scalds has the same components as the medicament for treating scalds in example 4;

uniformly mixing the boy urine, the hemp seeds, the crushed Chinese teasel, the pawpaw and the pearl powder to obtain a mixture;

Examples of the experiments

Selecting the medicaments for treating the scalds prepared in the embodiments 3 and 4 and the comparative examples 1-4;

purchasing 140 SD rats with half male and female, randomly dividing into 7 groups with half male and female in each group;

and (3) second-degree scald molding:

respectively removing hairs on the backs of rats, then anesthetizing the rats by adopting ammonium chloride hydrate, and then scalding the backs of the rats by using metal to form a second-degree scald wound surface with the diameter of 3 cm;

taking medicine:

the rats of groups 1 to 6 were sequentially applied with the scald-treating agents prepared in examples 3 and 4 and comparative examples 1 to 4, and group 7 was used as a negative control, and applied with physiological saline;

the application method comprises respectively spraying the medicinal preparation and normal saline on the surface of wound surface, and wrapping with medical gauze, wherein the spraying amount of the medicinal preparation for each rat is 2 ml; spraying three times every day with 4h interval; after continuously administering for two weeks, the wound surface condition is observed, and in the test process, one rat is accidentally killed in the groups 2 and 5;

and (4) judging the curative effect, wherein the judgment standard is as follows:

the effect is shown: the crust peels are removed, no infection is caused, and no obvious scar is left;

the method has the following advantages: the crust skin is not completely peeled off, and the skin of the peeled crust skin part is red without infection;

and (4) invalidation: infection phenomenon exists, and the tissue at the bottom of the crust skin is not repaired.

The test results, as shown in table 1:

TABLE 1

As can be seen from Table 1:

compared with a negative control group, the medicaments for treating scalds prepared in the embodiments 3 and 4 and the comparative examples 1-4 have the effect of treating scalds; compared with the embodiment 3 and the embodiment 4, the significant efficiency of treating rats is improved by adding the hemp grains; compared with the comparative examples 1 to 3, the change of the raw materials and the dosage of the raw materials has little influence on the effective rate of rats, but obviously reduces the effective rate of treating rats.

Finally, it should be noted that: the above embodiments are only used to illustrate the technical solution of the present invention, and not to limit the same; while the invention has been described in detail and with reference to the foregoing embodiments, it will be understood by those skilled in the art that: the technical solutions described in the foregoing embodiments may still be modified, or some or all of the technical features may be equivalently replaced; such modifications and substitutions do not depart from the spirit and scope of the present invention, and they should be construed as being included in the following claims and description.

Claims

1. The medicament for treating the scalds is characterized by being prepared from the following raw materials in parts by weight:

2. The medicament according to claim 1, which is prepared from the following raw materials in parts by weight:

3. The medicament of claim 1 or 2, wherein the starting material further comprises:

90-110 g of hemp and millet.

4. The medicament of claim 3, wherein the hemp grain is 100 g.

5. The medicament of claim 1, wherein the river pearl has a particle size of not less than 300 mesh.

6. The method of preparing the pharmaceutical formulation of claim 1, comprising the steps of:

7. The method of claim 6, further comprising:

dissolving fructus Cannabis in the concentrated solution.

8. The preparation method according to claim 6 or 7, wherein the decoction time is 1-2 hours.

9. The method according to claim 6 or 7, wherein the concentration is performed by concentrating the decocted solution to a relative density of 1.2 to 1.4 at 30 ℃.

10. The production method according to claim 6 or 7, characterized by further comprising: