CN111658864A - Integrated extracorporeal membrane lung life support system - Google Patents
Integrated extracorporeal membrane lung life support system Download PDFInfo
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- CN111658864A CN111658864A CN202010677077.8A CN202010677077A CN111658864A CN 111658864 A CN111658864 A CN 111658864A CN 202010677077 A CN202010677077 A CN 202010677077A CN 111658864 A CN111658864 A CN 111658864A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
- A61M1/3621—Extra-corporeal blood circuits
- A61M1/3666—Cardiac or cardiopulmonary bypass, e.g. heart-lung machines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
- A61M1/16—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes
- A61M1/1621—Constructional aspects thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
- A61M1/16—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes
- A61M1/1698—Blood oxygenators with or without heat-exchangers
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
- A61M1/3621—Extra-corporeal blood circuits
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2202/00—Special media to be introduced, removed or treated
- A61M2202/04—Liquids
- A61M2202/0413—Blood
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- Heart & Thoracic Surgery (AREA)
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Abstract
The invention provides an integrated extracorporeal membrane lung life support system, which comprises a shell, a blood pump and a membrane lung gas exchanger, wherein the shell is provided with a blood inlet, a blood outlet, a gas inlet and a gas outlet; including first cavity, second cavity in the casing, installation membrane lung gas exchanger in the first cavity, installation blood pump in the second cavity, first cavity and second cavity intercommunication each other are provided with blood import, gas inlet and gas outlet on the first cavity, are provided with the blood export on the second cavity. The invention integrates the blood pump and the membrane-lung gas exchanger, compared with an ECLS system with the blood pump and the membrane-lung gas exchanger separated, because the pipeline connection between the blood pump and the membrane-lung gas exchanger is avoided, the clinical operation does not need to worry about the accidental falling of the pipeline connection and the generation of bubbles, and the safety is greatly improved.
Description
Technical Field
The invention relates to the technical field of medical instruments, in particular to an integrated extracorporeal membrane lung life support system.
Background
An extracorporeal membrane lung life support system provides a complete or partial replacement of cardiopulmonary function in patients with clinically impaired cardiopulmonary function. An extracorporeal membrane lung Life Support system (ECLS) draws blood from a patient's vein, passes through an extracorporeal membrane lung gas exchanger to oxygenate hemoglobin, removes carbon dioxide, and returns the gas-exchanged blood to the patient's body, thereby playing a role in replacing all or part of the heart and lung and maintaining oxygenation and blood supply of human organ tissues. The alternate functioning of the cardiac respiratory circulatory system by ECLS may place the patient's heart and lungs in a fully or partially resting state, gaining valuable time for the patient's treatment and recovery. Two clinically common modes of application are veno-arterial (V-a) and veno-venous (V-V). The V-A mode directly returns blood from the vein to the systemic arterial circulation after oxygenation and carbon dioxide discharge. The V-V mode returns oxygenated blood to the central vein, primarily through blood exchange with gases. The ECLS design is based on a structure simulating the internal circulation of a human body, and comprises a blood pump for replacing the power of a circulation system, a gas exchanger (membrane lung) for replacing the function of a respiratory system, arteriovenous catheters and pipelines for replacing a circulation system loop, various monitoring displays and other additional devices. Wherein the blood pump acts as an artificial heart and the gas exchanger acts as an artificial lung.
The extracorporeal membrane lung life support system was used only for severe cardiopulmonary dysfunction of newborns from the outset; the ever-expanding range of applications has been used to treat patients with various heart or (and) lung failure, such as acute myocardial infarction, acute myocarditis, acute heart failure, acute intractable arrhythmia, heart failure after heart operation, primary graft failure after heart transplantation, acute drug toxicity heart failure, sudden cardiac arrest, and other heart failure; acute respiratory failure, acute respiratory distress syndrome associated with viral or bacterial pneumonia, graft dysfunction after lung transplantation, lung contusion due to extensive trauma, pulmonary embolism, failure to provide adequate gas exchange without the risk of ventilatory injury, pulmonary hemorrhage, severe bronchospasm, and other pulmonary failure. Circulatory support has also been reported in recent years for patients in the transition phase of organ transplantation; or for protecting donor organs after the donor has died out.
Although many patent technologies improve the performance and design of the conventional blood pump and blood-gas exchanger, in clinical application, in order to reduce the length and complexity of the connecting pipeline of the blood pump and the gas exchanger and facilitate the management and transportation of patients, especially in the emergency scene, the design is more compact.
Patent document No. CN106421951A discloses an extracorporeal membrane oxygenation device, comprising: the blood pump is connected with a blood vessel cannula at the inlet end, the oxygenator is connected at the outlet end, and the blood outlet of the oxygenator is sequentially connected with a heat exchange device and a thrombus filtering device; the blood pump comprises: the cam and the first piston assembly and the second piston assembly which are installed in a matched mode are arranged on the cam, the first piston assembly is identical to the second piston assembly in structure, and the cam comprises a wheel body and a plurality of arc-shaped protruding blocks which are evenly arranged on the periphery of the wheel body in a staggered mode. This patent document provides a reliable, more stable adventitia pulmonary oxygenation device that reduces thrombus, reduces damage to blood cells, and uses a novel blood pump, which makes the transport of blood more stable, and the pulse is very small, and there is no damage to blood cells by a vane pump. However, in the patent document, the integration level of the blood pump and the oxygenator is not high, the route of extracorporeal circulation is longer, and the number of connecting pipelines is more, so that the risk of accidental falling of the pipelines is increased, and the carrying is inconvenient.
Disclosure of Invention
In view of the deficiencies in the prior art, it is an object of the present invention to provide an integrated extracorporeal membrane lung life support system.
The invention provides an integrated extracorporeal membrane lung life support system, which comprises a shell, a blood pump and a membrane lung gas exchanger, wherein the shell is provided with a blood inlet, a blood outlet, a gas inlet and a gas outlet;
including first cavity, second cavity in the casing, installation membrane lung gas exchanger in the first cavity, installation blood pump in the second cavity, first cavity and second cavity intercommunication each other are provided with blood import, gas inlet and gas outlet on the first cavity, are provided with the blood export on the second cavity.
Preferably, the membrane-lung gas exchanger comprises a gas exchange membrane, the gas exchange membrane is wound into a ring shape and is arranged in the first cavity, and the axis of the ring-shaped gas exchange membrane is collinear with the axis of the first cavity.
Preferably, a gap is formed between the annular gas exchange membrane and the inner wall of the first cavity.
Preferably, the membrane lung gas exchanger comprises a gas exchange membrane wound around the axis of the first cavity.
Preferably, the gas exchange membrane is woven by hollow fibers.
Preferably, the blood pump comprises a centrifugal impeller, a fixed shaft and a driving device, wherein a partition plate is arranged in the second cavity, the partition plate divides the second cavity into an impeller mounting space and a driving mounting space which are not communicated with each other, and the impeller mounting space is communicated with the first cavity;
the centrifugal impeller is arranged in the impeller mounting space, the driving device is arranged in the driving mounting space, the fixed shaft is arranged on the isolation plate, and the centrifugal impeller is arranged on the fixed shaft through a bearing and can rotate relative to the fixed shaft;
magnetic materials are integrated on the centrifugal impeller, the driving device adopts a magnetic driver, and the driving device can drive the centrifugal impeller to rotate.
Preferably, the blood inlet and the blood outlet are respectively provided with a pressure sensor.
Preferably, the gas inlet and the gas outlet are respectively provided with an oxygen sensor and a carbon dioxide sensor.
Preferably, the first cavity and the second cavity are coaxially arranged.
Preferably, the housing is a body of revolution.
Compared with the prior art, the invention has the following beneficial effects:
1. the invention integrates the blood pump and the membrane-lung gas exchanger, compared with an ECLS system with the blood pump and the membrane-lung gas exchanger separated, because the pipeline connection between the blood pump and the membrane-lung gas exchanger is avoided, the clinical operation does not need to worry about the accidental falling of the pipeline connection and the generation of bubbles, and the safety is greatly improved.
2. The invention integrates the blood pump and the membrane-lung gas exchanger, greatly shortens the length of the loop pipeline of the whole ECLS system, reduces the contact between blood and the surface of a foreign body in the pipeline, further reduces the damage to the blood and reduces the side effect.
3. The invention integrates the blood pump and the membrane lung gas exchanger, has compact structure, convenient carrying and simple and convenient use and operation, can be placed beside or at the side of a sickbed or even directly worn on the body, has short extracorporeal circulation time because the length of the extracorporeal circulation pipeline is greatly shortened, and can not need to be matched with an additional heating device in clinic, thus further simplifying the operation.
4. The invention adopts magnetic drive, the installation space of the driving device is completely isolated from the cavity where the blood is located, the pollution and damage of the driving device to the blood are further avoided, and the side effect is reduced.
5. According to the invention, the blood pump drives the blood to rotate in the first cavity and the second cavity, so that the blood moves along the axial direction and the tangential direction of the gas exchange membrane, and efficient gas exchange is realized.
Drawings
Other features, objects and advantages of the invention will become more apparent upon reading of the detailed description of non-limiting embodiments with reference to the following drawings:
FIG. 1 is a schematic structural view of the present invention, wherein 1A is a blood inlet, 1B is a blood outlet, 1C is a gas inlet, and 1D is a gas outlet.
Fig. 2 is a schematic structural diagram of a membrane lung gas exchanger according to an embodiment of the present invention.
FIG. 3 is a schematic structural view of the hollow fiber woven gas exchange membrane of the present invention.
Fig. 4 is a schematic structural diagram of the hollow fiber of the present invention, which is a schematic structural diagram of a top view, a schematic structural diagram of a front view, and a schematic structural diagram of a perspective view from top to bottom.
Fig. 5 is a schematic structural view of the blood pump of the present invention, showing the centrifugal impeller, the stationary shaft and the partition plate, the driving means being shielded by the partition plate.
Detailed Description
The present invention will be described in detail with reference to specific examples. The following examples will assist those skilled in the art in further understanding the invention, but are not intended to limit the invention in any way. It should be noted that it would be obvious to those skilled in the art that various changes and modifications can be made without departing from the spirit of the invention. All falling within the scope of the present invention.
In the description of the present application, it is to be understood that the terms "upper", "lower", "front", "rear", "left", "right", "vertical", "horizontal", "top", "bottom", "inner", "outer", and the like indicate orientations or positional relationships based on those shown in the drawings, and are only for convenience in describing the present application and simplifying the description, but do not indicate or imply that the referred device or element must have a specific orientation, be constructed in a specific orientation, and be operated, and thus, should not be construed as limiting the present application.
The invention discloses an integrated extracorporeal membrane lung life support system, which consists of a blood pump driven by magnetic suspension and a novel membrane lung gas exchanger. The membrane-lung gas exchanger in the same shell is connected with the impeller of the blood pump by a channel, thereby completely avoiding any pipeline connection between the blood pump and the membrane-lung gas exchanger. The blood can contact with the membrane lung gas exchanger along the axial direction and the tangential direction, thereby realizing high-efficiency gas exchange. Can be used for the extracorporeal support of all or part of cardiopulmonary functions, such as extracorporeal membrane oxygenation (ECMO), extracorporeal carbon dioxide removal (ECCO2R), and organ preservation.
According to the integrated extracorporeal membrane lung life support system provided by the invention, as shown in fig. 1-5, the system comprises a shell, a blood pump and a membrane lung gas exchanger, wherein a blood inlet, a blood outlet, a gas inlet and a gas outlet are arranged on the shell; including first cavity, second cavity in the casing, installation membrane lung gas exchanger in the first cavity, installation blood pump in the second cavity, first cavity and second cavity intercommunication each other are provided with blood import, gas inlet and gas outlet on the first cavity, are provided with the blood export on the second cavity.
Preferably, as shown in fig. 1, the blood inlet is arranged in the middle of the top of the first cavity, the blood outlet is arranged outside the bottom of the second cavity, the gas inlet is arranged on the side of the upper part of the first cavity, the gas outlet is arranged on the side of the lower part of the first cavity, the blood pump is arranged in the middle of the bottom of the second cavity, the membrane-lung gas exchanger is arranged in the first cavity, and the blood pump and the membrane-lung gas exchanger are completely integrated in the communicated cavities without any pipeline connection. In a variation, the first cavity and the second cavity are communicated to form a cavity, a blood pump is mounted in the middle of the bottom in the cavity, membrane-lung gas exchangers are arranged above and circumferentially on the blood pump, a blood inlet is arranged in the middle of the top of the cavity, a blood outlet is arranged on the outer side of the bottom of the cavity, a gas inlet is arranged on the side surface of the upper part of the cavity, and a gas outlet is arranged on the side surface of the lower part of the cavity. Driven by the blood pump, the blood led out from the vein of the patient enters the integrated extracorporeal membrane lung life support system from the blood inlet (1A), flows through the membrane lung gas exchanger, exchanges gas with the gas, then flows out from the blood outlet (1B), and is sent back to the body of the patient through a pipeline. Oxygen and air are mixed according to different proportions, enter the membrane lung gas exchanger through the gas inlet (1C) and exit from the gas outlet (1D).
The present invention can be used in combination with system control monitoring displays (including monitoring and display of system operating parameters such as blood temperature, flow rate, pressure, arteriovenous oxygen saturation, etc.), and additional devices required by the system (such as oxygen lines, flow sensors, etc.).
In one embodiment, as shown in fig. 2, the membrane-lung gas exchanger comprises a gas exchange membrane disposed in a first cavity in a ring shape, and an axis of the ring-shaped gas exchange membrane is collinear with an axis of the first cavity. A gap is formed between the annular gas exchange membrane and the inner wall of the first cavity. Under the action of the blood pump, the blood entering from the blood inlet rotationally moves along the axial direction and the tangential direction of the annular gas exchange membrane to exchange gas with the gas exchange membrane. The gap is arranged to enable gas entering from the gas inlet to rapidly diffuse into the annular gas exchange membrane from the circumferential direction of the annular gas exchange membrane.
In another embodiment, the membrane lung gas exchanger comprises a gas exchange membrane wound around the axis of the first cavity. The blood moves along the coiled gas exchange membrane under the action of the blood pump and contacts with the gas exchange membrane to realize gas exchange.
As shown in fig. 3 to 4, the gas exchange membrane is woven by hollow fibers, so that high-efficiency blood gas exchange can be realized. The gas exchange membrane functions equivalently to a respiratory membrane. The gas exchange performance can be adjusted by adjusting the thickness, material, inner diameter, etc. of the hollow fiber. The performance of the gas exchange can also be adjusted by adding a coating on the inner wall or the outer wall of the hollow fiber.
The blood pump is a magnetic suspension centrifugal pump or a magnetic force drive pump, as shown in fig. 5, the blood pump comprises a centrifugal impeller, a fixed shaft and a drive device, a partition board is arranged in the second cavity, the partition board divides the second cavity into an impeller installation space and a drive installation space which are not communicated with each other, and the impeller installation space is communicated with the first cavity; the centrifugal impeller is arranged in the impeller mounting space, the driving device is arranged in the driving mounting space, the fixed shaft is arranged on the isolation plate, preferably in the center of the isolation plate, and the centrifugal impeller is arranged on the fixed shaft through a bearing and can rotate relative to the fixed shaft; magnetic materials are integrated on the centrifugal impeller, the driving device adopts a magnetic driver, and the driving device can drive the centrifugal impeller to rotate. The blood side (blood cavity) and the driving side (driving installation space) are completely separated through the isolation plate, so that the pollution and damage of the driving device to the blood are further avoided, and the side effect is reduced.
And the blood inlet and the blood outlet are respectively provided with a pressure sensor. And the gas inlet and the gas outlet are respectively provided with an oxygen sensor and a carbon dioxide sensor. The pressure sensor adopts an embedded sensor and can measure the pressure of blood flowing in and out.
The first cavity and the second cavity are coaxially arranged, the shell is a revolving body, blood can flow along the axial direction and the tangential direction of the shell conveniently, resistance caused by edges and corners in the flowing process is reduced, and gas exchange is more stable and uniform.
Aiming at different application scenes, the invention can optimally adjust the sizes and the structures of different components to optimally meet the requirements of clinical application. For example, in neonatal or pediatric patients where low blood flow is desired, the size of the blood pump and the membrane-lung gas exchanger of the present invention may be optimized for low flow applications, which may also be suitable for adult patients requiring only partial cardiac or pulmonary function support. In the case of an adult patient requiring full cardiopulmonary support, such as cardiac surgery, or waiting for an organ transplant transition period, where the blood flow requirements may be 6-8L/min, the size of the blood pump and the MEA gas exchanger of the present invention may be optimally adjusted for high flow applications. The invention can optimize and adjust the material type and winding mode of the hollow fiber membrane in the membrane lung gas exchanger to achieve the best effect of removing carbon dioxide.
The foregoing description of specific embodiments of the present invention has been presented. It is to be understood that the present invention is not limited to the specific embodiments described above, and that various changes or modifications may be made by one skilled in the art within the scope of the appended claims without departing from the spirit of the invention. The embodiments and features of the embodiments of the present application may be combined with each other arbitrarily without conflict.
Claims (10)
1. An integrated extracorporeal membrane lung life support system is characterized by comprising a shell, a blood pump and a membrane lung gas exchanger, wherein the shell is provided with a blood inlet, a blood outlet, a gas inlet and a gas outlet;
including first cavity, second cavity in the casing, installation membrane lung gas exchanger in the first cavity, installation blood pump in the second cavity, first cavity and second cavity intercommunication each other are provided with blood import, gas inlet and gas outlet on the first cavity, are provided with the blood export on the second cavity.
2. The integrated extracorporeal membrane lung life support system of claim 1, wherein the membrane lung gas exchanger comprises a gas exchange membrane wound in a ring shape disposed within the first cavity, the axis of the ring-shaped gas exchange membrane being collinear with the axis of the first cavity.
3. The integrated extracorporeal membrane lung life support system of claim 2, wherein a gap is provided between the annular gas exchange membrane and the inner wall of the first cavity.
4. The integrated extracorporeal membrane lung life support system of claim 1, wherein the membrane lung gas exchanger comprises a gas exchange membrane that is coiled around an axis of the first cavity.
5. The integrated extracorporeal membrane lung life support system of claim 2 or 4, wherein the gas exchange membrane is woven from hollow fibers.
6. The integrated extracorporeal membrane lung life support system of claim 1, wherein the blood pump comprises a centrifugal impeller, a stationary shaft, and a drive device, a partition is disposed in the second chamber, the partition divides the second chamber into two impeller installation spaces and a drive installation space that are not in communication with each other, the impeller installation space being in communication with the first chamber;
the centrifugal impeller is arranged in the impeller mounting space, the driving device is arranged in the driving mounting space, the fixed shaft is arranged on the isolation plate, and the centrifugal impeller is arranged on the fixed shaft through a bearing and can rotate relative to the fixed shaft;
magnetic materials are integrated on the centrifugal impeller, the driving device adopts a magnetic driver, and the driving device can drive the centrifugal impeller to rotate.
7. The integrated extracorporeal membrane lung life support system of claim 1, wherein the blood inlet and the blood outlet are each provided with a pressure sensor.
8. The integrated extracorporeal membrane lung life support system of claim 1, wherein the gas inlet and the gas outlet are provided with an oxygen sensor and a carbon dioxide sensor, respectively.
9. The integrated extracorporeal membrane lung life support system of claim 1, wherein the first cavity is disposed coaxially with the second cavity.
10. The integrated extracorporeal membrane lung life support system of claim 1, wherein the housing is a solid of revolution.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202010677077.8A CN111658864A (en) | 2020-07-14 | 2020-07-14 | Integrated extracorporeal membrane lung life support system |
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| Application Number | Priority Date | Filing Date | Title |
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| CN202010677077.8A CN111658864A (en) | 2020-07-14 | 2020-07-14 | Integrated extracorporeal membrane lung life support system |
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| CN111658864A true CN111658864A (en) | 2020-09-15 |
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| CN202010677077.8A Pending CN111658864A (en) | 2020-07-14 | 2020-07-14 | Integrated extracorporeal membrane lung life support system |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113425930A (en) * | 2021-06-28 | 2021-09-24 | 上海交通大学 | Successive layer oxygenation artificial pump lung auxiliary device driven by ultrasonic linear motor |
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| US20080199357A1 (en) * | 2006-12-07 | 2008-08-21 | Levitronix Llc | Integrated centrifugal blood pump-oxygenator, an extracorporeal life support system and a method of de-bubbling and priming an extracorporeal life support system |
| CN103619374A (en) * | 2010-12-07 | 2014-03-05 | 措尔生命桥梁有限责任公司 | Method and system for filling and venting a device for extracorporeal blood treatment, with stepped flooding of a filter |
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| CN213219799U (en) * | 2020-07-14 | 2021-05-18 | 卫圣康医学科技(江苏)有限公司 | Integrated extracorporeal membrane lung life support system |
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| JPH0595998A (en) * | 1991-10-14 | 1993-04-20 | Nikkiso Co Ltd | Pump-oxygenator |
| US20080199357A1 (en) * | 2006-12-07 | 2008-08-21 | Levitronix Llc | Integrated centrifugal blood pump-oxygenator, an extracorporeal life support system and a method of de-bubbling and priming an extracorporeal life support system |
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| CN113425930A (en) * | 2021-06-28 | 2021-09-24 | 上海交通大学 | Successive layer oxygenation artificial pump lung auxiliary device driven by ultrasonic linear motor |
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