CN111658535B - System and method for preparing roxithromycin capsules - Google Patents

System and method for preparing roxithromycin capsules Download PDF

Info

Publication number
CN111658535B
CN111658535B CN202010544781.6A CN202010544781A CN111658535B CN 111658535 B CN111658535 B CN 111658535B CN 202010544781 A CN202010544781 A CN 202010544781A CN 111658535 B CN111658535 B CN 111658535B
Authority
CN
China
Prior art keywords
fixedly connected
stirring
support
packing
shaking
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CN202010544781.6A
Other languages
Chinese (zh)
Other versions
CN111658535A (en
Inventor
付长华
方焱琳
吴迎庆
万俊俊
陆江涛
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Zhejiang Huayuan Pharmaceutical Co.,Ltd.
Original Assignee
Huayuan Pharmaceutical LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Huayuan Pharmaceutical LLC filed Critical Huayuan Pharmaceutical LLC
Priority to CN202010544781.6A priority Critical patent/CN111658535B/en
Publication of CN111658535A publication Critical patent/CN111658535A/en
Application granted granted Critical
Publication of CN111658535B publication Critical patent/CN111658535B/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
    • A61J3/07—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of capsules or similar small containers for oral use
    • A61J3/071—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of capsules or similar small containers for oral use into the form of telescopically engaged two-piece capsules
    • A61J3/074—Filling capsules; Related operations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/485—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4866—Organic macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F23/00—Mixing according to the phases to be mixed, e.g. dispersing or emulsifying
    • B01F23/70—Pre-treatment of the materials to be mixed
    • B01F23/713—Sieving materials
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F23/00—Mixing according to the phases to be mixed, e.g. dispersing or emulsifying
    • B01F23/80—After-treatment of the mixture
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F27/00—Mixers with rotary stirring devices in fixed receptacles; Kneaders
    • B01F27/80—Mixers with rotary stirring devices in fixed receptacles; Kneaders with stirrers rotating about a substantially vertical axis
    • B01F27/90—Mixers with rotary stirring devices in fixed receptacles; Kneaders with stirrers rotating about a substantially vertical axis with paddles or arms 
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B07—SEPARATING SOLIDS FROM SOLIDS; SORTING
    • B07B—SEPARATING SOLIDS FROM SOLIDS BY SIEVING, SCREENING, SIFTING OR BY USING GAS CURRENTS; SEPARATING BY OTHER DRY METHODS APPLICABLE TO BULK MATERIAL, e.g. LOOSE ARTICLES FIT TO BE HANDLED LIKE BULK MATERIAL
    • B07B1/00—Sieving, screening, sifting, or sorting solid materials using networks, gratings, grids, or the like
    • B07B1/28—Moving screens not otherwise provided for, e.g. swinging, reciprocating, rocking, tilting or wobbling screens
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B07—SEPARATING SOLIDS FROM SOLIDS; SORTING
    • B07B—SEPARATING SOLIDS FROM SOLIDS BY SIEVING, SCREENING, SIFTING OR BY USING GAS CURRENTS; SEPARATING BY OTHER DRY METHODS APPLICABLE TO BULK MATERIAL, e.g. LOOSE ARTICLES FIT TO BE HANDLED LIKE BULK MATERIAL
    • B07B1/00—Sieving, screening, sifting, or sorting solid materials using networks, gratings, grids, or the like
    • B07B1/42—Drive mechanisms, regulating or controlling devices, or balancing devices, specially adapted for screens
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B07—SEPARATING SOLIDS FROM SOLIDS; SORTING
    • B07B—SEPARATING SOLIDS FROM SOLIDS BY SIEVING, SCREENING, SIFTING OR BY USING GAS CURRENTS; SEPARATING BY OTHER DRY METHODS APPLICABLE TO BULK MATERIAL, e.g. LOOSE ARTICLES FIT TO BE HANDLED LIKE BULK MATERIAL
    • B07B1/00—Sieving, screening, sifting, or sorting solid materials using networks, gratings, grids, or the like
    • B07B1/46—Constructional details of screens in general; Cleaning or heating of screens
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B07—SEPARATING SOLIDS FROM SOLIDS; SORTING
    • B07B—SEPARATING SOLIDS FROM SOLIDS BY SIEVING, SCREENING, SIFTING OR BY USING GAS CURRENTS; SEPARATING BY OTHER DRY METHODS APPLICABLE TO BULK MATERIAL, e.g. LOOSE ARTICLES FIT TO BE HANDLED LIKE BULK MATERIAL
    • B07B2201/00—Details applicable to machines for screening using sieves or gratings
    • B07B2201/04—Multiple deck screening devices comprising one or more superimposed screens

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Inorganic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The invention relates to preparation of a capsule product, in particular to a roxithromycin capsule preparation system which comprises a device bracket, a stirring bracket, a filler bracket, a screening mechanism, a shaking mechanism, a filler mechanism and a stirring mechanism, and can efficiently and quickly complete the processes of screening, filling and stirring raw materials and particles30The solubility of the roxithromycin is improved, the low-substituted hypromellose is added to lead the granules to be quickly disintegrated into fine powder, which is beneficial to the dissolution of the medicine, and the improvement of the preparation method is used for extractingThe dissolution rate of the homoroxithromycin capsules improves the quality standard of products, so that the medicine for patients is safer and more effective.

Description

System and method for preparing roxithromycin capsules
Technical Field
The invention relates to preparation of capsule products, in particular to a system and a method for preparing roxithromycin capsules.
Background
The roxithromycin capsule belongs to macrolide antibiotics and is mainly used for pharyngitis and tonsillitis caused by streptococcus pyogenes, acute attack of nasosinusitis, otitis media, acute bronchitis and chronic bronchitis caused by sensitive bacteria, pneumonia caused by mycoplasma pneumoniae or chlamydia pneumoniae, urethritis and cervicitis caused by chlamydia trachomatis, skin and soft tissue infection caused by sensitive bacteria and the like. The roxithromycin capsules are widely applied clinically. In the preparation process of the roxithromycin capsules, the common preparation method easily causes the problems of raw material adhesion and aggregation, poor particle fluidity, difficult control of loading amount, low medicine dissolution rate and the like, and the existing preparation device can not rapidly complete the processes of raw material and particle screening, filling and stirring.
Disclosure of Invention
The invention aims to provide a system and a method for preparing roxithromycin capsules, which can overcome the adhesion and aggregation of raw materials, enhance the flowability of granules, ensure accurate loading amount, improve the dissolution rate of the roxithromycin capsules, provide a device capable of quickly completing the screening, filling and stirring processes of the raw materials and the granules, and improve the production efficiency.
The purpose of the invention is realized by the following technical scheme:
the utility model provides a system for preparation of roxithromycin capsule, includes device support, stirring support, filler support, screening mechanism, shake mechanism, filler mechanism and rabbling mechanism, fixedly connected with stirring support on the device support, fixedly connected with filler support on the stirring support, screening mechanism and shake mechanism all are provided with two, and two screening mechanisms are placed respectively on device support and filler support, and two shake mechanisms are fixed connection respectively on device support and filler support, and shake mechanism drive screening mechanism shakes on the device support or filler support that correspond, and filler mechanism connects on filler support, fixedly connected with rabbling mechanism in the stirring support, filler mechanism and stirring leg joint.
As further optimization of the technical scheme, the roxithromycin capsule preparation system comprises a device support, two side supports and two mounting supports I, wherein the mounting supports I are fixedly connected between the upper ends of the two side supports, and the storage box is fixedly connected between the lower ends of the two side supports.
As a further optimization of the technical scheme, the roxithromycin capsule preparation system comprises a stirring support and a stirring device, wherein the stirring support comprises a discharging cylinder section, a stirring cylinder section, a mounting support II and a shaking hole I, the upper end of the discharging cylinder section is fixedly connected with the stirring cylinder section, the mounting support II is fixedly connected onto the discharging cylinder section, a plurality of shaking holes I are formed in the mounting support II, and the discharging cylinder section is fixedly connected onto a containing box.
As a further optimization of the technical scheme, the roxithromycin capsule preparation system comprises a plurality of filling frames and a plurality of shaking holes II, wherein the plurality of filling frames are provided with the shaking holes II, the plurality of filling frames are fixedly connected to the mounting bottom plate, and the mounting bottom plate is fixedly connected to the stirring cylinder section.
As a further optimization of the technical scheme, the roxithromycin capsule preparation system comprises a screening mechanism, two screening plates, connecting columns and two blocking plates, wherein the screening plates are detachably and fixedly connected in the screening bracket, the screening bracket is fixedly connected with the connecting columns, the blocking plates are fixedly connected on the connecting columns, the connecting columns are respectively placed in the shaking holes II, the connecting columns are respectively placed in the shaking holes I, the lower ends of the blocking plates are respectively contacted with the packing frames, and the lower ends of the blocking plates are respectively contacted with the mounting bracket II.
As a further optimization of the technical scheme, the roxithromycin capsule preparation system comprises two shaking mechanisms and a shaking motor, wherein the shaking mechanism comprises a shaking motor and two shaking cranks, the output shaft of the shaking motor is fixedly connected with the shaking cranks, the shaking motor positioned on the upper side is fixedly connected to one of the filling frames, the shaking motor positioned on the lower side is fixedly connected to the mounting bracket II, and the shaking cranks are fixedly connected to the corresponding stop plates.
As a further optimization of the technical scheme, the invention relates to a system for preparing roxithromycin capsules, which comprises a stuffing box, arc baffles, stuffing rotating columns, a discharging groove, a telescopic mechanism I, a stuffing bottom plate, a stuffing motor and stuffing pipelines, wherein the stuffing box is fixedly connected with the two arc baffles, the stuffing rotating columns are rotatably connected between the two arc baffles, the discharging groove is arranged on each stuffing rotating column, the telescopic mechanism I is fixedly connected in the discharging groove, the telescopic end of the telescopic mechanism I is fixedly connected with the stuffing bottom plate, the stuffing bottom plate is slidably connected in the discharging groove, each stuffing frame is fixedly connected with the stuffing box, the stuffing rotating columns are in transmission connection, the transmission ratio among the stuffing rotating columns is one, the stuffing motor is fixedly connected on one stuffing box, the output shaft of the stuffing motor is fixedly connected with the corresponding stuffing rotating column, the stuffing pipeline is fixedly connected at the lower end of each stuffing box, a plurality of filler pipelines are all connected with the stirring cylinder section.
As further optimization of the technical scheme, the roxithromycin capsule preparation system comprises a telescopic mechanism II, a stirring motor, a stirring bottom plate and stirring fan blades, wherein the telescopic mechanism II is fixedly connected in the discharging barrel section, the telescopic end of the telescopic mechanism II is fixedly connected with the stirring motor, the output shaft of the stirring motor is rotatably connected with the stirring bottom plate, and the stirring fan blades are fixedly connected on the stirring bottom plate.
A method of preparing a roxithromycin capsule, the method comprising the steps of:
the method comprises the following steps: weighing 1500 parts of roxithromycin, 280 parts of starch and 160 parts of low-substituted hydroxypropyl cellulose according to the parts by weight, collecting the materials through a 100-mesh sieve, and uniformly mixing the materials in a high-efficiency wet granulation machine;
step two: weighing 5 parts of poloxamer and 5 parts of povidone K according to parts by weight30Adding 28 parts of the mixture into purified water for dissolving; adding the solution into a high-efficiency wet-process granulator, uniformly mixing, and preparing into granules through a 18-mesh sieve, wherein the drying temperature is 60 ℃, and drying until the moisture of the granules is not higher than 3.0%;
step three: screening the mixture by a screening mechanism positioned at the upper side and dropping the mixture into a stirring bracket, and placing silicon dioxide, talcum powder and magnesium stearate into a filling mechanism in advance;
step four: and the filling mechanism is used for adding 45 parts of silicon dioxide, 35 parts of talcum powder and 10 parts of magnesium stearate into the stirring bracket according to parts by weight, the stirring mechanism is used for uniformly mixing, and the screening mechanism falling to the lower side is used for further screening and then is used for filling into capsules to obtain the roxithromycin capsules.
As the further optimization of the technical scheme, the method for preparing the roxithromycin capsules comprises the step of sieving a sieve plate with 100 meshes or 18 meshes.
The invention relates to a system for preparing roxithromycin capsules, which comprises the following steps:
according to the system for preparing the roxithromycin capsules, disclosed by the invention, the corresponding screening mechanism can be driven by the shaking mechanism positioned on the upper side to screen raw materials, the raw materials screened by the screening mechanism fall into the stirring support, the filling mechanism moves for a period to provide different types of other raw materials with different use requirements into the stirring support, the raw materials in the stirring support are uniformly mixed by the stirring mechanism, and the corresponding screening mechanism is driven by the shaking mechanism positioned on the lower side to shake for further screening and then is filled into the capsules to obtain the roxithromycin capsules.
The invention relates to a method for preparing roxithromycin capsules, which comprises the following steps:
the method for preparing the roxithromycin capsules has high reliability and high production efficiency, the roxithromycin capsules are dried at the drying temperature of 60 ℃, the influence of high temperature on the melting of the granules is prevented, the granules have better fluidity by adding the silicon dioxide, the talcum powder and the magnesium stearate, and the poloxamer and the povidone K are added30Improves the solubility of roxithromycin, and is addedThe addition of the low-substituted hypromellose can lead the granules to be quickly disintegrated into fine powder, which is beneficial to the dissolution of the medicine, and the improvement of the preparation method can improve the dissolution rate of the roxithromycin capsule, improve the quality standard of the product and lead the medicine administration of patients to be safer and more effective.
Drawings
The invention is described in further detail below with reference to the accompanying drawings and specific embodiments.
In the description of the present invention, it should be noted that the terms "center", "longitudinal", "lateral", "up", "down", "front", "back", "left", "right", "top", "bottom", "inner", "outer" and "upright", etc., indicate orientations or positional relationships based on those shown in the drawings, and are only for convenience of description and simplicity of description, but do not indicate or imply that the referred device or element must have a specific orientation, be constructed and operated in a specific orientation, and thus, should not be construed as limiting the present invention.
In the description of the present invention, it should be noted that unless otherwise explicitly stated or limited, the terms "mounted," "connected," and "connected" are to be construed broadly, and may be, for example, fixedly connected, detachably connected, or integrally connected, directly or indirectly connected through an intermediate medium, and may be a communication between two members. The specific meanings of the above terms in the present invention can be understood in specific cases to those skilled in the art.
In addition, in the description of the present invention, the meaning of "a plurality", and "a plurality" is two or more unless otherwise specified.
FIG. 1 is a schematic diagram of the overall structure of a system for preparing roxithromycin capsules according to the invention;
FIG. 2 is a schematic diagram of a cross-sectional view of a system for preparing the roxithromycin capsules of the invention;
FIG. 3 is a schematic view of the device support structure of the present invention;
FIG. 4 is a schematic view of the stirring support structure of the present invention;
FIG. 5 is a schematic view of the packing support of the present invention;
FIG. 6 is a schematic structural view of the sifting mechanism of the present invention;
FIG. 7 is a schematic structural diagram of the dithering mechanism of the present invention;
FIG. 8 is a schematic structural view of the packing mechanism of the present invention;
FIG. 9 is a schematic cross-sectional structural view of the packing mechanism of the present invention;
fig. 10 is a schematic structural view of the stirring mechanism of the present invention.
In the figure: a device holder 1; side brackets 101; a storage box 102; a mounting bracket I103; a stirring support 2; a discharge barrel section 201; a drum section 202; a mounting bracket II 203; a dither hole I204; a filler holder 3; mounting a base plate 301; a packing frame 302; a dithering hole II 303; a screening mechanism 4; a screening carrier 401; a screening plate 402; a connecting post 403; a blocking plate 404; a shaking mechanism 5; a shaking motor 501; a wobble crank 502; a filling mechanism 6; a stuffing box 601; a circular arc baffle 602; a packing rotating column 603; a discharge chute 604; a telescoping mechanism I605; a packing shoe 606; a stuffing motor 607; a filler conduit 608; a stirring mechanism 7; a telescoping mechanism II 701; a stirring motor 702; a stir bottom plate 703; stirring blades 704.
Detailed Description
The present invention will be described in further detail with reference to the accompanying drawings.
The first embodiment is as follows:
the system for preparing roxithromycin capsules according to the embodiment is described below with reference to fig. 1 to 10, and comprises a device bracket 1, a stirring bracket 2, a filling bracket 3, a screening mechanism 4, a shaking mechanism 5, a filling mechanism 6 and a stirring mechanism 7, fixedly connected with stirring support 2 on the device support 1, fixedly connected with filler support 3 on the stirring support 2, screening mechanism 4 and shake mechanism 5 all are provided with two, two screening mechanisms 4 are placed respectively on device support 1 and filler support 3, two shake mechanism 5 are fixed connection respectively on device support 1 and filler support 3, shake mechanism 5 drive screening mechanism 4 and shake on the device support 1 or filler support 3 that correspond, filler mechanism 6 is connected on filler support 3, fixedly connected with rabbling mechanism 7 in the stirring support 2, filler mechanism 6 and stirring support 2 are connected.
The second embodiment is as follows:
the present embodiment is described below with reference to fig. 1 to 10, and the present embodiment further describes the first embodiment, the apparatus bracket 1 includes two side brackets 101, a storage box 102, and a mounting bracket i 103, the two side brackets 101 are provided, the mounting bracket i 103 is fixedly connected between the upper ends of the two side brackets 101, and the storage box 102 is fixedly connected between the lower ends of the two side brackets 101.
The third concrete implementation mode:
the following describes the present embodiment with reference to fig. 1 to 10, and the second embodiment is further described in the present embodiment, where the stirring support 2 includes a discharging cylinder section 201, a stirring cylinder section 202, a mounting support ii 203 and a shaking hole i 204, the upper end of the discharging cylinder section 201 is fixedly connected with the stirring cylinder section 202, the discharging cylinder section 201 is fixedly connected with the mounting support ii 203, the mounting support ii 203 is provided with a plurality of shaking holes i 204, and the discharging cylinder section 201 is fixedly connected to the storage box 102.
The fourth concrete implementation mode:
the following describes the present embodiment with reference to fig. 1 to 10, and the present embodiment further describes an embodiment three, where the filler support 3 includes a mounting base plate 301, a plurality of filler frames 302 and a plurality of shaking holes ii 303, the plurality of filler frames 302 are provided with the shaking holes ii 303, the plurality of filler frames 302 are all fixedly connected to the mounting base plate 301, and the mounting base plate 301 is fixedly connected to the stirring cylinder section 202.
The fifth concrete implementation mode:
the following describes the present embodiment with reference to fig. 1 to 10, and the fourth embodiment is further described, where the screening mechanism 4 includes a screening bracket 401, two screening plates 402, two connecting columns 403 and two blocking plates 404, the screening plate 402 is detachably and fixedly connected to the screening bracket 401, the screening bracket 401 is fixedly connected to a plurality of connecting columns 403, the connecting columns 403 are all fixedly connected to the connecting columns 403, the two blocking plates 404 are all fixedly connected to the connecting columns 403, the screening mechanism 4 is provided with two screening mechanisms, the connecting columns 403 located on the upper side are respectively placed in the shaking holes ii 303, the connecting columns 403 located on the lower side are respectively placed in the shaking holes i 204, the lower ends of the blocking plates 404 located on the upper side are respectively contacted with the packing frames 302, and the lower ends of the blocking plates 404 located on the lower side are respectively contacted with the mounting bracket ii 203.
The sixth specific implementation mode:
the embodiment is described below with reference to fig. 1 to 10, and the fifth embodiment is further described in the present embodiment, where the shaking mechanism 5 includes a shaking motor 501 and shaking cranks 502, the shaking cranks 502 are fixedly connected to the output shaft of the shaking motor 501, two shaking mechanisms 5 are provided, the shaking motor 501 located on the upper side is fixedly connected to one of the packing frames 302, the shaking motor 501 located on the lower side is fixedly connected to the mounting bracket ii 203, and the shaking cranks 502 are fixedly connected to the corresponding blocking plates 404.
The seventh embodiment:
the present embodiment is described below with reference to fig. 1 to 10, and further described in the present embodiment, the filling mechanism 6 includes a filling box 601, an arc baffle 602, a filling rotary column 603, a material discharge chute 604, a telescoping mechanism i 605, a filling bottom plate 606, a filling motor 607, and a filling pipe 608, two arc baffles 602 are fixedly connected in the filling box 601, the filling rotary column 603 is rotatably connected between the two arc baffles 602, the material discharge chute 604 is disposed on the filling rotary column 603, the telescoping mechanism i 605 is fixedly connected in the material discharge chute 604, the telescoping end of the telescoping mechanism i 605 is fixedly connected with the filling bottom plate 606, the filling bottom plate 606 is slidably connected in the material discharge chute 604, the filling box 601 is fixedly connected on each filling frame 302, the plurality of filling rotary columns 603 are in transmission connection, the transmission ratio among the plurality of filling rotary columns 603 is one, the filling motor 607 is fixedly connected on one filling box 601, the output shaft of the packing motor 607 is fixedly connected with the corresponding packing rotating column 603, the lower end of each packing box 601 is fixedly connected with a packing pipeline 608, and the plurality of packing pipelines 608 are connected with the stirring cylinder section 202.
The specific implementation mode is eight:
the following describes the present embodiment with reference to fig. 1 to 10, and the seventh embodiment is further described in the present embodiment, where the stirring mechanism 7 includes a telescopic mechanism ii 701, a stirring motor 702, a stirring bottom plate 703 and stirring blades 704, the telescopic mechanism ii 701 is fixedly connected in the discharging barrel section 201, the telescopic end of the telescopic mechanism ii 701 is fixedly connected with the stirring motor 702, an output shaft of the stirring motor 702 is rotatably connected with the stirring bottom plate 703, and the stirring bottom plate 703 is fixedly connected with the stirring blades 704.
A method of preparing a roxithromycin capsule, the method comprising the steps of:
the method comprises the following steps: weighing 1500 parts of roxithromycin, 280 parts of starch and 160 parts of low-substituted hydroxypropyl cellulose according to the parts by weight, collecting the materials through a 100-mesh sieve, and uniformly mixing the materials in a high-efficiency wet granulation machine;
step two: weighing 5 parts of poloxamer and 5 parts of povidone K according to parts by weight30Adding 28 parts of the mixture into purified water for dissolving; adding the solution into a high-efficiency wet-process granulator, uniformly mixing, and preparing into granules through a 18-mesh sieve, wherein the drying temperature is 60 ℃, and drying until the moisture of the granules is not higher than 3.0%;
step three: screening the mixture by a screening mechanism 4 positioned at the upper side to fall into the stirring bracket 2, and placing the silicon dioxide, the talcum powder and the magnesium stearate into a filling mechanism 6 in advance;
step four: the filling mechanism 6 adds 45 parts of silicon dioxide, 35 parts of talcum powder and 10 parts of magnesium stearate into the stirring bracket 2 according to the parts by weight, the stirring mechanism 7 uniformly mixes the materials, the screening mechanism 4 falling on the lower side further screens the materials, and the materials are filled into capsules to obtain roxithromycin capsules; the sieving plate 402 is 100 mesh or 18 mesh sieve.
The invention relates to a system and a method for preparing roxithromycin capsules, which have the working principle that:
when the filling machine is used, silicon dioxide, talcum powder and magnesium stearate are respectively placed in the three filling boxes 601, the silicon dioxide, the talcum powder and the magnesium stearate are added to enable the flowability of particles to be better, the silicon dioxide, the talcum powder and the magnesium stearate respectively fall on the filling bottom plate 606, the telescopic mechanism I605 can be a hydraulic cylinder or an electric push rod, the telescopic end of the telescopic mechanism I605 pushes the filling bottom plate 606 to slide in the discharging groove 604, the height of the filling bottom plate 606 in the discharging groove 604 is adjusted according to use requirements, and the quantity of raw materials in each discharging groove 604 is adjusted; weighing according to the weight portionCollecting 1500 g of roxithromycin, 280 g of starch and 160 g of low-substituted hydroxypropyl cellulose, passing through a 100-mesh sieve, and uniformly mixing in a high-efficiency wet granulating machine; weighing 5 parts of poloxamer and 5 parts of povidone K according to parts by weight30Adding 28 parts of the mixture into purified water for dissolving; adding the solution into a high-efficiency wet-process granulator, uniformly mixing, and preparing into granules through a 18-mesh sieve, wherein the drying temperature is 60 ℃, and drying until the moisture of the granules is not higher than 3.0%; high production efficiency, drying at 60 deg.C to prevent high temperature from affecting granule melting, and adding poloxamer and polyvidone K30The solubility of the roxithromycin is improved, the low-substituted hydroxypropyl methylcellulose is added to ensure that the granules are quickly disintegrated into fine powder, so that the dissolution of the medicine is facilitated, the dissolution rate of the roxithromycin capsules is improved, related substances of the product are reduced, the quality standard of the product is improved, and the medicine for patients is safer and more effective; raw materials which are screened into particles are placed on the screening plate 402 positioned on the upper side, the corresponding shaking motor 501 is started, the output shaft of the shaking motor 501 drives the shaking crank 502 to move, the shaking crank 502 drives the screening bracket 401 to shake on the filler bracket 3, and the screening plate 402 screens the raw materials and then drops on the stirring bottom plate 703 in the stirring cylinder section 202; starting the packing motor 607, it should be noted that the packing motor 607 rotates only one turn each time the packing motor 607 is started, the output shaft of the packing motor 607 starts to rotate, the output shaft of the packing motor 607 drives the corresponding packing rotating columns 603 to rotate, the plurality of packing rotating columns 603 are in transmission connection, the transmission ratio between the plurality of packing rotating columns 603 is one, the plurality of packing rotating columns 603 rotate together, as shown in fig. 9, when the packing rotating columns 603 rotate, the raw material in the corresponding discharging chute 604 falls into the packing pipeline 608, and falls into the stirring cylinder section 202 through the packing pipeline 608; the filling mechanism 6 is used for adding 45 g of silicon dioxide, 35 g of talcum powder and 10 g of magnesium stearate into the stirring support 2 according to parts by weight, starting the telescopic mechanism II 701 and the stirring motor 702, wherein the telescopic mechanism II 701 can be a hydraulic cylinder or an electric push rod, the telescopic end of the telescopic mechanism II 701 moves downwards, and the output shaft of the stirring motor 702 rotates to drive the stirring bottom plate 703 and the stirring fan blades 704 to rotate so as to mix and stir the raw materials; downward movement speed of telescopic end of telescopic mechanism II 701The degree can be controlled, and further the stirring time can be controlled; when the telescopic end of the telescopic mechanism II 701 moves to the discharging cylinder section 201, as shown in fig. 4, the diameter of the discharging cylinder section 201 is larger than that of the stirring cylinder section 202, the raw materials fall onto the sieving plate 402 on the lower side under the rotation of the stirring bottom plate 703, and the raw materials fall onto the sieving mechanism 4 on the lower side for further sieving and then are filled into capsules to obtain roxithromycin capsules.
It is to be understood that the above description is not intended to limit the present invention, and the present invention is not limited to the above examples, and that various changes, modifications, additions and substitutions which are within the spirit and scope of the present invention and which may be made by those skilled in the art are also within the scope of the present invention.

Claims (4)

1. The utility model provides a system of roxithromycin capsule preparation, includes device support (1), stirring support (2), filler support (3), screening mechanism (4), shake mechanism (5), filler mechanism (6) and rabbling mechanism (7), its characterized in that: the device is characterized in that a stirring support (2) is fixedly connected to the device support (1), a filler support (3) is fixedly connected to the stirring support (2), two screening mechanisms (4) and two shaking mechanisms (5) are respectively arranged on the device support (1) and the filler support (3), the two shaking mechanisms (5) are respectively and fixedly connected to the device support (1) and the filler support (3), the shaking mechanisms (5) drive the screening mechanisms (4) to shake on the corresponding device support (1) or the filler support (3), the filler mechanisms (6) are connected to the filler support (3), stirring mechanisms (7) are fixedly connected to the inside of the stirring support (2), and the filler mechanisms (6) are connected to the stirring support (2);
the device support (1) comprises side supports (101), storage boxes (102) and mounting supports I (103), the number of the side supports (101) is two, the mounting supports I (103) are fixedly connected between the upper ends of the two side supports (101), and the storage boxes (102) are fixedly connected between the lower ends of the two side supports (101);
the stirring support (2) comprises a discharging cylinder section (201), a stirring cylinder section (202), a mounting support II (203) and shaking holes I (204), the upper end of the discharging cylinder section (201) is fixedly connected with the stirring cylinder section (202), the mounting support II (203) is fixedly connected onto the discharging cylinder section (201), a plurality of shaking holes I (204) are formed in the mounting support II (203), and the discharging cylinder section (201) is fixedly connected onto the containing box (102);
the packing support (3) comprises a mounting base plate (301), packing frames (302) and shaking holes II (303), a plurality of packing frames (302) are arranged, the shaking holes II (303) are arranged on the packing frames (302), the packing frames (302) are fixedly connected to the mounting base plate (301), and the mounting base plate (301) is fixedly connected to the stirring barrel section (202);
the screening mechanism (4) comprises a screening support (401), a screening plate (402), connecting columns (403) and blocking plates (404), the screening plate (402) is detachably and fixedly connected in the screening support (401), a plurality of connecting columns (403) are fixedly connected on the screening support (401), the blocking plates (404) are fixedly connected on the connecting columns (403), two screening mechanisms (4) are arranged, the connecting columns (403) on the upper side are respectively placed in the shaking holes II (303), the connecting columns (403) on the lower side are respectively placed in the shaking holes I (204), the lower ends of the blocking plates (404) on the upper side are respectively contacted with the packing frames (302) on the lower side, and the lower ends of the blocking plates (404) are respectively contacted with the mounting support II (203);
the shaking mechanism (5) comprises shaking motors (501) and shaking cranks (502), the shaking cranks (502) are fixedly connected to the output shafts of the shaking motors (501), two shaking mechanisms (5) are arranged, the shaking motor (501) positioned on the upper side is fixedly connected to one of the packing frames (302), the shaking motor (501) positioned on the lower side is fixedly connected to the mounting bracket II (203), and the shaking cranks (502) are fixedly connected to the corresponding blocking plates (404);
the packing mechanism (6) comprises a packing box (601), arc baffles (602), packing rotating columns (603), a discharging groove (604), a telescopic mechanism I (605), a packing bottom plate (606), a packing motor (607) and a packing pipeline (608), wherein the two arc baffles (602) are fixedly connected in the packing box (601), the packing rotating column (603) is rotatably connected between the two arc baffles (602), the discharging groove (604) is arranged on the packing rotating column (603), the telescopic mechanism I (605) is fixedly connected in the discharging groove (604), the packing bottom plate (606) is fixedly connected with the telescopic end of the telescopic mechanism I (605), the packing bottom plate (606) is slidably connected in the discharging groove (604), the packing box (601) is fixedly connected on each packing frame (302), the packing rotating columns (603) are in transmission connection, the transmission ratio among the packing rotating columns (603) is one, one of the stuffing boxes (601) is fixedly connected with a stuffing motor (607), an output shaft of the stuffing motor (607) is fixedly connected with a corresponding stuffing rotating column (603), the lower end of each stuffing box (601) is fixedly connected with a stuffing pipeline (608), and a plurality of stuffing pipelines (608) are connected with the stirring cylinder section (202).
2. A system for preparing roxithromycin capsules according to claim 1, wherein: the stirring mechanism (7) comprises a telescopic mechanism II (701), a stirring motor (702), a stirring bottom plate (703) and stirring fan blades (704), the telescopic mechanism II (701) is fixedly connected in the discharging barrel section (201), the telescopic end of the telescopic mechanism II (701) is fixedly connected with the stirring motor (702), the stirring bottom plate (703) is rotatably connected on an output shaft of the stirring motor (702), and the stirring fan blades (704) are fixedly connected on the stirring bottom plate (703).
3. A system for the preparation of roxithromycin capsules according to claim 2, wherein: the screening plate (402) is a 100-mesh or 18-mesh screen.
4. A method of preparing a roxithromycin capsule using a roxithromycin capsule preparation system of claim 3, wherein: the method comprises the following steps:
the method comprises the following steps: weighing 1500 parts of roxithromycin, 280 parts of starch and 160 parts of low-substituted hydroxypropyl cellulose according to the parts by weight, collecting the materials through a 100-mesh sieve, and uniformly mixing the materials in a high-efficiency wet granulation machine;
step two: weighing 5 parts of poloxamer and 5 parts of povidone K according to parts by weight30Adding 28 parts of the mixture into purified water for dissolving; adding the solution into a high-efficiency wet-process granulator, uniformly mixing, and preparing into granules through a 18-mesh sieve, wherein the drying temperature is 60 ℃, and drying until the moisture of the granules is not higher than 3.0%;
step three: screening by a screening mechanism (4) positioned at the upper side and falling into the stirring bracket (2), and placing silicon dioxide, talcum powder and magnesium stearate into a filling mechanism (6) in advance;
step four: and the filling mechanism (6) is used for adding 45 parts of silicon dioxide, 35 parts of talcum powder and 10 parts of magnesium stearate into the stirring bracket (2) according to parts by weight, the stirring mechanism (7) is used for uniformly mixing, the screening mechanism (4) falling on the lower side is used for further screening, and the roxithromycin capsules are obtained after being filled into capsules.
CN202010544781.6A 2020-06-15 2020-06-15 System and method for preparing roxithromycin capsules Active CN111658535B (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN202010544781.6A CN111658535B (en) 2020-06-15 2020-06-15 System and method for preparing roxithromycin capsules

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN202010544781.6A CN111658535B (en) 2020-06-15 2020-06-15 System and method for preparing roxithromycin capsules

Publications (2)

Publication Number Publication Date
CN111658535A CN111658535A (en) 2020-09-15
CN111658535B true CN111658535B (en) 2021-11-09

Family

ID=72388185

Family Applications (1)

Application Number Title Priority Date Filing Date
CN202010544781.6A Active CN111658535B (en) 2020-06-15 2020-06-15 System and method for preparing roxithromycin capsules

Country Status (1)

Country Link
CN (1) CN111658535B (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113304050B (en) * 2021-06-07 2023-03-21 南京望知星医药科技有限公司 Production equipment and method of roxithromycin microcapsules

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103083278B (en) * 2011-11-04 2015-06-03 四川科伦药物研究有限公司 Roxithromycin capsule and preparation method thereof
CN203292061U (en) * 2013-05-02 2013-11-20 郑州国燃耐火材料有限公司 Device for sieving, mixing and discharging refractory raw material
CN106138009A (en) * 2016-07-29 2016-11-23 花园药业股份有限公司 Roxithromycin capsules and preparation technology thereof
CN109248155B (en) * 2018-09-27 2020-08-11 北京鑫开元医药科技有限公司 Roxithromycin capsule and preparation process thereof
CN109569353B (en) * 2018-11-14 2021-09-10 聊城义利化工有限公司 Discharging equipment for industrial liquid raw materials
CN209333602U (en) * 2018-11-26 2019-09-03 卢冰 A kind of premixing feedstuff accurate quantification mixing arrangement

Also Published As

Publication number Publication date
CN111658535A (en) 2020-09-15

Similar Documents

Publication Publication Date Title
CN111658535B (en) System and method for preparing roxithromycin capsules
CN107583544A (en) A kind of agitator arm movable type chemical raw material mixing device
CN1209099C (en) Agglomerates by crystallisation
CN210159538U (en) Granular potash fertilizer granulator
CN1040945C (en) Process for preparing a clodronate preparation
CN111632530B (en) System and method for preparing valsartan amlodipine tablets
CN1957936A (en) Silybin tiny pellets and preparation method
CN1951373A (en) Method for preparing nimodipine dispersible tablet with high dissolution
CN115318202A (en) Compound fertilizer is to roll-type extrusion prilling granulator with refining function
CN103406069A (en) Wet granulation machine and medicinal granule preparation method using same
CN113951400A (en) Feed formula capable of increasing meat yield of eel, production process and equipment
CN109134041B (en) Preparation method of compound fertilizer
EP0479097A1 (en) Process for preparing water-sparingly soluble fertilizer granules
CN218358846U (en) Reducing mechanism is used in ceramic powder system
CN217449919U (en) Dosing unit is used in processing of powder cleaner
CN111632034A (en) Preparation process and equipment of carbocisteine tablets
CN207871151U (en) A kind of new medicine granulator
CN218854108U (en) Efficient mixing arrangement
CN220143210U (en) Medicinal three-dimensional mixer
CN215312043U (en) Agitating unit is used in production of chemical raw material medicine
CN116984221B (en) Soil screening device and method for improving fruit planting environment
CN216934067U (en) Full-automatic pill making equipment for medicament production
CN216877922U (en) Cooling crystallization device for preparing 2-methoxy-4-methyl aminobenzoate
CN216910212U (en) Medicine mixing and granulating equipment
CN217490759U (en) Oscillating granulator for pharmacy

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination
GR01 Patent grant
GR01 Patent grant
CP03 Change of name, title or address

Address after: 321000 Huayuan Industrial Zone, Nanma Town, Dongyang City, Jinhua City, Zhejiang Province

Patentee after: Zhejiang Huayuan Pharmaceutical Co.,Ltd.

Address before: 322121 Huayuan Industrial Zone, Nanma Town, Dongyang City, Jinhua City, Zhejiang Province

Patentee before: HUAYUAN PHARMACEUTICAL LLC

CP03 Change of name, title or address