CN111653356A - New coronary pneumonia screening method and new coronary pneumonia screening system based on deep learning - Google Patents

New coronary pneumonia screening method and new coronary pneumonia screening system based on deep learning Download PDF

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CN111653356A
CN111653356A CN202010312993.1A CN202010312993A CN111653356A CN 111653356 A CN111653356 A CN 111653356A CN 202010312993 A CN202010312993 A CN 202010312993A CN 111653356 A CN111653356 A CN 111653356A
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probability
classification
coronary pneumonia
new coronary
lesion area
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吴炜
李旭锟
杜鹏
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Zhejiang University ZJU
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Abstract

The invention discloses a new coronary pneumonia screening method and a new coronary pneumonia screening system based on deep learning, wherein the new coronary pneumonia screening method comprises the following steps: the lung lesion region of CT is detected by a deep learning detection model, and then is sent to a three-classification network, wherein the three classifications comprise COVID-19, influenza A and no infection symptom. Then, the diagnosis result of CT and the probability of illness are output through calculation processing. The method is based on deep learning and automatic learning of the characteristics of CT images to distinguish COVID-19, influenza A and healthy people, the accuracy of the method is high, the total accuracy of the current test reaches 86.7%, the diagnosis speed is high, and only 30-60S is needed for one set of CT according to different slice numbers. The user can upload the CT image file through the new coronary pneumonia screening system, and calculate and output the diagnosis result and the illness probability of CT, so that the operation is convenient, the speed is high, and the detection rate of COVID-19 is greatly improved.

Description

New coronary pneumonia screening method and new coronary pneumonia screening system based on deep learning
Technical Field
The invention belongs to the technical field of medicine, and particularly relates to a new coronary pneumonia screening method and a new coronary pneumonia screening system based on deep learning.
Background
In the early screening of the novel coronary pneumonia (COVID-19), detection is mainly carried out by means of a kit at present, but the detection rate is low, and in order to improve the detection rate of the COVID-19 in the early screening, some other auxiliary methods need to be adopted for judgment, such as a CT image judgment method and the like.
Some methods for detecting lung lesion tissues exist in the prior art, for example, patent document No. CN110599448A discloses a migration learning lung lesion tissue detection system based on MaskScoring R-CNN network, which inputs a lung CT image to be detected, outputs the network to obtain an identified image, frames and masks the lesion tissues identified by mask, and marks the category of the lesion. However, during training, the mask of a diseased region needs to be calculated, a large amount of resources are consumed for marking, and the operation is complicated, so that the method is not suitable for detecting the novel coronary pneumonia (COVID-19) for improving the early screening detection rate of the COVID-19.
Disclosure of Invention
The invention provides a new coronary pneumonia screening method based on deep learning, which is used for identifying influenza A, new coronary and normal CT, is convenient to operate, outputs the whole infection probability and assists a doctor in diagnosing.
The technical scheme of the invention is as follows: a new coronary pneumonia screening method based on deep learning comprises the following steps:
s1, extracting a mask of the effective area of the lung;
s2, segmenting the effective region of the lung by using the extracted mask, reducing the influence of irrelevant regions, and normalizing the Hu value of the original CT;
s3, segmenting a lung lesion region by using a 3D convolutional neural network, and outputting position information of the lesion region, wherein the position information comprises coordinates (x, y, z) of a central point and the diameter D of the lesion region;
s4, detecting a two-dimensional lesion area image of the middle layer at the lesion area position, and simultaneously acquiring adjacent images above and below the two-dimensional lesion area image, namely acquiring three images in total;
s5, sending the classified images into a two-dimensional classification network, training, and judging that the images are COVID-19 and influenza A or normal;
s6, predicting the image cut out in the step S4 by using the trained model, and outputting the classification and the classification probability;
s7, calculating the classification and probability of a single lesion area for the three images divided from each lesion area;
and S8, calculating the classification and the probability of the single lesion area obtained in the step S7, and outputting the overall disease type and the probability of the single patient.
The invention judges the CT image of a patient by utilizing a deep learning technology, automatically learns the image characteristics of the patient and distinguishes influenza A from healthy people. The invention firstly utilizes a deep learning detection model to detect the lung lesion area of CT, and then sends the lung lesion area into a three-classification network, wherein the three classifications comprise COVID-19, influenza A and no infection symptom. Then, the diagnosis result of CT and the probability of illness are output through calculation processing.
Preferably, in step S2, the Hu value of the original CT is normalized to 0-255.
Preferably, in step S7, the classification and probability of a single lesion region are calculated by using a bayesian noise-or model.
Preferably, in step S8, the classification and probability of the single lesion region obtained in step S7 are calculated by using a bayesian noise-or model, and the overall disease type and probability of the single patient are output.
The invention also provides a new coronary pneumonia screening system based on the web interface, which comprises the following components:
the image acquisition module is used for acquiring CT original compressed files;
the decompression module is used for decompressing the CT original compressed file acquired by the image acquisition module;
the format judgment module is used for carrying out format judgment on the decompressed file decompressed by the decompression module and screening to obtain a CT image in a lung window format in CT;
the data processing module is used for calculating and processing the CT image in the lung window format in the CT obtained by screening of the format judging module and calculating the integral disease type and probability of a single patient;
and the display module is used for displaying the processing result of the data processing module.
The invention also develops an application system of the web application interface, which is used for uploading the original compressed CT file; decompressing the uploaded CT compressed file, judging whether the format of the file is correct or not, and screening out a set of CT images in a lung window format in CT; sending the arranged CT image into a data processing module for processing; and finally, obtaining a result calculated by the data processing module and displaying the result. The user can upload the CT image file through the web interface, the background algorithm side calculates, the diagnosis result and the sick probability of the CT are output, and the detection rate is improved.
Preferably, the data processing module calculates the classification and the probability of a single lesion area by using a Bayesian noise-or model, then calculates the classification and the probability of the single lesion area by using the Bayesian noise-or model, and outputs the whole disease type and the probability of a single patient.
Compared with the prior art, the invention has the beneficial effects that:
(1) the lung lesion area of the CT is detected by using a deep learning detection model, and then is sent to a three-classification network, wherein the three classifications comprise COVID-19, influenza A and no infection symptom; then, the diagnosis result of CT and the probability of illness are output through calculation processing. The method is based on deep learning and automatic learning of the characteristics of CT images to distinguish COVID-19, influenza A and healthy people, the accuracy of the method is high, the total accuracy of the current test reaches 86.7%, the diagnosis speed is high, and only 30-60S is needed for one set of CT according to different slice numbers.
(2) The invention also develops an application system of the web application interface, which can be used by doctors and the like, and users can upload CT image files through the web interface of the invention, and the background algorithm side can calculate and output the diagnosis result and the illness probability of CT, thereby not only having convenient operation, but also having high speed and greatly improving the detection rate of COVID-19.
(3) The lung lesion tissue detection method is convenient to operate, can directly output the trained lung lesion tissue detection model to the lesion tissue, and is more efficient and concise compared with the existing lung lesion tissue detection method.
Detailed Description
The technical solution in the embodiments of the present invention is clearly and completely described below. It should be understood that the specific embodiments described herein are merely illustrative of the invention and are not intended to limit the invention. All other embodiments, which can be derived by a person skilled in the art from the embodiments of the invention without inventive step, are within the scope of the invention.
Example 1
A new coronary pneumonia screening method based on deep learning specifically comprises the following steps:
s1 extracting mask of effective area of lung
S2, segmenting the effective region of the lung by using the extracted mask, reducing the influence of irrelevant regions, and normalizing the Hu value of the original CT to 0-255;
s3, segmenting a lung lesion region by using a 3D convolutional neural network, and outputting position information of the lesion region, wherein the position information comprises coordinates (x, y, z) of a central point and the diameter D of the lesion region;
s4, detecting the two-dimensional lesion area image of the middle layer of the lesion area position, and simultaneously acquiring the adjacent images above and below the two-dimensional lesion area image, wherein the total three images are
S5, sending the classified images into a two-dimensional classification network for training, and judging whether the images are COVID-19, influenza A or normal;
s6, predicting the image cut out in the step 4 by using the trained model, and outputting the classification and the classification probability;
s7, calculating the three pictures divided from each lesion region by using a Bayesian noise-or model, and calculating the classification and probability of each lesion region;
and S8, calculating the classification and the probability of the single lesion area obtained in the step S7 by using a Bayesian noise-or model, and outputting the overall disease type and the probability of the single patient.
In the embodiment, a deep learning detection model is used for detecting a lung lesion region of CT, and then the lung lesion region is sent into a three-classification network, wherein the three classifications comprise COVID-19, influenza A and no infection symptom; then, the diagnosis result of CT and the probability of illness are output through calculation processing. The total accuracy rate of the method reaches 86.7 percent, the diagnosis speed is high, and a set of CT only needs 30 to 60 seconds according to different number of slices.
Example 2
This embodiment is a new crown pneumonia screening system based on web interface, which is designed on the basis of embodiment 1, and includes:
the image acquisition module is used for acquiring CT original compressed files;
the decompression module is used for decompressing the CT original compressed file acquired by the image acquisition module;
the format judgment module is used for carrying out format judgment on the decompressed file decompressed by the decompression module and screening to obtain a CT image in a lung window format in CT;
the data processing module is used for calculating and processing the CT image in the lung window format in the CT obtained by screening of the format judging module and calculating the integral disease type and probability of a single patient;
and the display module is used for displaying the processing result of the data processing module.
The embodiment develops a web application interface, which is used for uploading a CT original compressed file, decompressing the uploaded CT compressed file and judging whether the format of the uploaded CT compressed file is correct or not; then screening out a set of CT images in a lung window format in CT; sending the sorted CT image into an algorithm module for processing; and finally, obtaining a result calculated by the algorithm module and displaying the result.
The invention is not limited to the above alternative embodiments, and any other various forms of products can be obtained by anyone in the light of the present invention, but any changes in shape or structure thereof, which fall within the scope of the present invention as defined in the claims, fall within the scope of the present invention.

Claims (6)

1. A new coronary pneumonia screening method based on deep learning is characterized by comprising the following steps:
s1, extracting a mask of the effective area of the lung;
s2, segmenting the effective region of the lung by using the extracted mask, reducing the influence of irrelevant regions, and normalizing the Hu value of the original CT;
s3, segmenting a lung lesion region by using a 3D convolutional neural network, and outputting position information of the lesion region, wherein the position information comprises coordinates (x, y, z) of a central point and the diameter D of the lesion region;
s4, detecting a two-dimensional lesion area image of the middle layer at the lesion area position, and simultaneously acquiring adjacent images above and below the two-dimensional lesion area image, namely acquiring three images in total;
s5, sending the classified images into a two-dimensional classification network, training, and judging that the images are COVID-19 and influenza A or normal;
s6, predicting the image cut out in the step S4 by using the trained model, and outputting the classification and the classification probability;
s7, calculating the classification and probability of a single lesion area for the three images divided from each lesion area;
and S8, calculating the classification and the probability of the single lesion area obtained in the step S7, and outputting the overall disease type and the probability of the single patient.
2. The deep learning-based new coronary pneumonia screening method of claim 1, wherein the Hu value of the original CT is normalized to 0 ~ 255 in the step S2.
3. The method for screening new coronary pneumonia according to claim 1 or 2, wherein the classification of single lesion area and its probability are calculated by using Bayesian noise-or model in step S7.
4. The method for screening new coronary pneumonia based on deep learning as claimed in claim 3, wherein the classification and probability of single lesion area obtained in step S7 in step S8 are calculated by using Bayesian noise-or model, and the overall disease type and probability of single patient are output.
5. A web interface-based new crown pneumonia screening system, comprising:
the image acquisition module is used for acquiring CT original compressed files;
the decompression module is used for decompressing the CT original compressed file acquired by the image acquisition module;
the format judgment module is used for carrying out format judgment on the decompressed file decompressed by the decompression module and screening to obtain a CT image in a lung window format in CT;
the data processing module is used for calculating and processing the CT image in the lung window format in the CT obtained by screening of the format judging module and calculating the integral disease type and probability of a single patient;
and the display module is used for displaying the processing result of the data processing module.
6. The web interface-based new coronary pneumonia screening system of claim 5, wherein the data processing module calculates the classification and probability of a single lesion area by using a Bayesian noise-or model, and then calculates the classification and probability of a single lesion area by using the Bayesian noise-or model, and outputs the overall disease type and probability of a single patient.
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CN113138250A (en) * 2021-04-23 2021-07-20 西湖大学 Non-diagnostic method for typing covid-19 grade by using characteristic urine protein and application

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