CN111632637A - Biochip detection device - Google Patents
Biochip detection device Download PDFInfo
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- CN111632637A CN111632637A CN202010503054.5A CN202010503054A CN111632637A CN 111632637 A CN111632637 A CN 111632637A CN 202010503054 A CN202010503054 A CN 202010503054A CN 111632637 A CN111632637 A CN 111632637A
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- B01L9/52—Supports specially adapted for flat sample carriers, e.g. for plates, slides, chips
- B01L9/527—Supports specially adapted for flat sample carriers, e.g. for plates, slides, chips for microfluidic devices, e.g. used for lab-on-a-chip
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- B01L2200/023—Adapting objects or devices to another adapted for different sizes of tubes, tips or container
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Abstract
The invention relates to the technical field of biochip detection, in particular to a biochip detection device, which comprises: the device comprises a detector, a detection table, an L-shaped frame plate, a sliding box body, a box cover and a driving mechanism; the detector is used for detecting the biochip; the detector is fixedly connected to the inner side of the box cover; the detection table is used for placing a biochip; the detector is arranged opposite to the detection table; the detection table is fixedly connected to the transverse plate of the L-shaped frame plate; the sliding box body is in sliding fit with the outer side of the detection table; the top and the bottom of the sliding box body are both arranged in an open manner; the box cover and the sliding box body are arranged oppositely up and down; the driving mechanism is connected to the vertical plate of the L-shaped frame plate; the invention can form a closed detection environment or a non-closed detection environment by adjusting the relative positions of the sliding box body, the box cover and the detection platform, thereby being convenient for meeting different detection requirements of different biochips.
Description
Technical Field
The invention relates to the technical field of biochip detection, in particular to a biochip detection device.
Background
In recent years, with the development of economic society, various detection needs have been increasing. Meanwhile, the breakthrough progress of material science, processing technology and microelectronics makes the biochip detection rapidly developed. In various detections, due to the advantages of small volume, low consumption of samples and reagents, controllable fluid, high integration level, high analysis speed and the like, the application of biochip detection is concerned, and the biochip detection is widely applied to the detection in the fields of biology, medicine, chemistry and the like. However, the conventional biochip measuring apparatus has a fixed structure, and cannot be rapidly switched between two measuring modes, i.e., a sealed measuring environment and a non-sealed measuring environment.
Disclosure of Invention
The invention aims to provide a biochip detection device, which can effectively solve the problems in the prior art; the invention can form a closed detection environment or a non-closed detection environment by adjusting the relative positions of the sliding box body, the box cover and the detection platform, thereby being convenient for meeting different detection requirements of different biochips.
To achieve the above object, the present application provides a biochip detecting apparatus comprising: the device comprises a detector, a detection table, an L-shaped frame plate, a sliding box body, a box cover and a driving mechanism; the detector is used for detecting the biochip; the detector is fixedly connected to the inner side of the box cover; the detection table is used for placing a biochip; the detector is arranged opposite to the detection table; the detection table is fixedly connected to the transverse plate of the L-shaped frame plate; the sliding box body is in sliding fit with the outer side of the detection table; the top and the bottom of the sliding box body are both arranged in an open manner; the box cover and the sliding box body are arranged oppositely up and down; the driving mechanism is connected to the vertical plate of the L-shaped frame plate; the driving mechanism is in transmission connection with the box cover and the sliding box body so as to drive the box cover and the sliding box body to be buckled or separated; the buckled box cover, the sliding box body and the detection platform form a closed detection box.
Optionally, the driving mechanism includes a first bidirectional screw, a first slider, a second slider and an adjusting wheel; two ends of the first bidirectional screw are rotatably matched with the upper end and the lower end of a vertical plate of the L-shaped frame plate; the first bidirectional screw is symmetrically connected with the first sliding block and the second sliding block through threads; the first sliding block and the second sliding block are in relative sliding fit in a longitudinal slide way of a vertical plate of the L-shaped frame plate; the first sliding block is fixedly connected with the box cover; the second sliding block is fixedly connected with the sliding box body; the first bidirectional screw is fixed with the adjusting rotating wheel.
Optionally, a rubber sealing gasket is arranged on a contact surface of the box cover and the sliding box body; and a rubber sealing gasket is arranged on the contact surface of the sliding box body and the detection platform.
Optionally, an exhaust pipe with a one-way valve is arranged on the box cover or the sliding box body, so that the exhaust pipe is matched with a vacuum pump to exhaust gas in the closed detection box, and a vacuum detection area is formed.
Optionally, the biochip detection apparatus further includes a light source mechanism; the plurality of light source mechanisms are arranged on the box cover in a surrounding manner; the light source mechanism comprises a laser, a rotary seat, a rotating shaft, a door-shaped seat, a worm wheel and a worm; the laser is arranged on the rotary seat; the rotating seat is fixedly connected to the rotating shaft; the rotating shaft is in rotating fit with the door-shaped seat; the door-shaped seat is fixed on the inner side of the box cover; the worm wheel is fixed on the rotating shaft; the worm in meshed transmission connection with the worm wheel is connected to the box cover in a sealing and rotating mode; and a rotating head is fixed at the top of the worm.
Optionally, the biochip detecting apparatus further includes a carrier mechanism; the carrier mechanism comprises a bearing table, a bearing shaft, a rotary driving motor with a speed reducer and a motor bracket; the bearing table is fixedly connected to the upper end of the bearing shaft; the middle part of the bearing shaft is in sealed rotation fit with the middle of the top surface of the detection table; the lower end of the bearing shaft is connected with an output shaft of the rotary driving motor through a coupler; the rotary driving motor is connected to the bearing platform or the transverse plate of the L-shaped frame plate through the motor bracket.
Optionally, the motor bracket comprises a horizontal bracket, an inclined support rod, a horizontal slider and a second bidirectional screw rod; the rotary driving motor is arranged on the horizontal bracket; two ends of the horizontal bracket are respectively and rotatably connected with one end of one inclined supporting rod, and the other ends of the two inclined supporting rods are respectively and rotatably connected to one horizontal sliding block; the two horizontal sliding blocks are in relative sliding fit in the horizontal slide way of the transverse plate of the L-shaped frame plate; two ends of the second bidirectional screw rod are respectively and rotatably matched with two ends of a transverse plate of the L-shaped frame plate; the two horizontal sliding blocks are symmetrically matched with two ends of the second bidirectional screw rod through threads.
Optionally, the carrier mechanism further includes four chip stoppers; the four chip blocking parts are connected to the four sides of the bearing table; the chip blocking piece comprises a horizontal screw rod, an adjusting wheel, a side blocking frame and a first pressure spring; four sides of the top surface of the bearing table are respectively provided with a rectangular sliding chute; two ends of the horizontal screw rod are respectively and rotatably matched with the inner end and the outer end of the rectangular sliding chute; the outer end of the horizontal screw is fixedly connected with the adjusting wheel; the side baffle frame is connected to the horizontal screw rod in a threaded fit manner; the side baffle frame is in sliding fit in the rectangular sliding groove; the horizontal screw rod is sleeved with the first pressure spring; the first pressure spring is located between the side blocking frame and the inner side face of the rectangular sliding groove.
Optionally, the chip stopper further comprises an upper baffle, a sliding screw, a limit nut, a second pressure spring and a tray; an upper slideway and a lower slideway are arranged on the side blocking frame; the middle part of the sliding screw is in sliding fit with the upper end of the side baffle frame; the bottom end of the sliding screw is connected with the tray in a rotating fit manner; the bottom surface inside the upper and lower slideways is provided with a containing groove matched with the tray; the upper baffle is in sliding fit with the sliding screw; the tray is blocked at the lower end of the upper baffle; the sliding screw rod between the upper baffle and the top surfaces of the upper and lower slideways is sleeved with the second pressure spring; the upper baffle is in sliding fit with the upper and lower slideways; the inner end of the upper baffle penetrates out of the side baffle frame; the sliding screw rod is connected with the limiting nut in a threaded fit manner; the limiting nut is blocked on the top surface of the side blocking frame.
Optionally, the carrier mechanism further comprises a stopper adjusting assembly; the stopper adjusting component comprises a friction transmission ring, a short column, a rotating ring and a poking plate; the friction transmission ring is vertically connected with the adjusting wheel of the chip stopper in a friction transmission manner; the bottom surface of the friction transmission ring is fixed on the rotating ring through a plurality of short columns which are uniformly arranged in a surrounding manner; the rotating ring is rotationally matched in an annular groove in the middle of the bearing table; the outer end of the friction transmission ring is fixedly connected with the poking plate.
The invention has the beneficial effects that:
the invention can form a closed detection environment or a non-closed detection environment by adjusting the relative positions of the sliding box body, the box cover and the detection platform, thereby being convenient for meeting different detection requirements of different biochips; the carrier mechanism capable of properly fixing the biochips with different sizes is adopted in the invention, so that the stability of the biochips in detection is improved conveniently, and the detection accuracy of the detector is improved; the plummer in the carrier mechanism can rotate under the cooperation of the rotary driving motor and the bearing shaft, and is convenient for carrying out better detection on the reaction results of different positions of the biochip through the detector.
In order to make the aforementioned and other objects, features and advantages of the present invention comprehensible, preferred embodiments accompanied with figures are described in detail below.
Drawings
In order to more clearly illustrate the technical solutions of the embodiments of the present invention or related technologies, the drawings used in the description of the embodiments or related technologies will be briefly introduced below, and it is obvious that the drawings in the following description are some embodiments of the present invention, and other drawings can be obtained by those skilled in the art without creative efforts.
FIG. 1 is a first general schematic diagram provided in accordance with an embodiment of the present invention;
FIG. 2 is a second overall view provided in accordance with an embodiment of the present invention;
FIG. 3 is a schematic view of a testing table according to an embodiment of the present invention;
fig. 4 is a schematic view of an L-shaped shelf board according to an embodiment of the present invention;
FIG. 5 is a schematic view of a sliding box according to an embodiment of the present invention;
FIG. 6 is a schematic view of a case cover according to an embodiment of the present invention;
FIG. 7 is a schematic view of a drive mechanism provided by an embodiment of the present invention;
FIG. 8 is a schematic diagram of a light source mechanism according to an embodiment of the present invention;
fig. 9 is a schematic view of a carrier mechanism according to an embodiment of the present invention;
fig. 10 is a schematic view of a carrier stage according to an embodiment of the invention;
FIG. 11 is a schematic view of a motor mount provided by an embodiment of the present invention;
FIG. 12 is a schematic view of a chip stopper according to an embodiment of the present invention;
fig. 13 is a schematic view of a flight adjustment assembly provided in accordance with an embodiment of the present invention.
Icon: a detector 1; a detection table 2; an L-shaped shelf plate 3; a slide case 4; a case cover 5; a drive mechanism 6; a first bidirectional screw 601; a first slider 602; a second slider 603; an adjustment wheel 604; a light source mechanism 7; a laser 701; a rotary base 702; a rotating shaft 703; a gantry 704; a worm gear 705; a worm 706; a carrier mechanism 8; a stage 801; a carrier shaft 802; a rotation driving motor 803; a motor mount 804; a horizontal bracket 804A; tilt strut 804B; a horizontal slider 804C; a second bidirectional screw 804D; a chip stopper 805; horizontal screw 805A; an adjustment wheel 805B; side ledges 805C; a first compression spring 805D; an upper baffle 805E; sliding screw 805F; a limit nut 805G; a second compression spring 805H; a tray 805I; a flight adjustment assembly 806; friction drive ring 806A; a stub 806B; a rotating ring 806C; toggle plate 806D.
Detailed Description
In order to make those skilled in the art better understand the technical solutions in the present application, the technical solutions in the embodiments of the present application will be clearly and completely described below, and it is obvious that the described embodiments are only a part of the embodiments of the present application, and not all embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present application.
It will be understood that when an element is referred to as being "fixed" or "disposed" on another element, it can be directly on the other element or be indirectly disposed on the other element; when an element is referred to as being "connected to" another element, it can be directly connected to the other element or be indirectly connected to the other element.
It will be understood that the terms "length," "width," "upper," "lower," "front," "rear," "left," "right," "vertical," "horizontal," "top," "bottom," "inner," "outer," and the like, refer to an orientation or positional relationship illustrated in the drawings for convenience in describing the present application and to simplify description, and do not indicate or imply that the referenced device or element must have a particular orientation, be constructed and operated in a particular orientation, and thus should not be construed as limiting the present application.
Furthermore, the terms "first", "second" and "first" are used for descriptive purposes only and are not to be construed as indicating or implying relative importance or implicitly indicating the number of technical features indicated. Thus, a feature defined as "first" or "second" may explicitly or implicitly include one or more of that feature. In the description of the present application, the meaning of a plurality of or a plurality of is two or more unless specifically limited otherwise.
It should be understood that the structures, ratios, sizes, and the like shown in the drawings and described in the specification are only used for understanding and reading the contents disclosed in the specification, and are not used for limiting the conditions that the present application can implement, so the present invention has no technical significance, and any structural modification, ratio relationship change or size adjustment should still fall within the scope of the technical content disclosed in the present application without affecting the efficacy and the achievable purpose of the present application. In addition, the terms "upper", "lower", "left", "right", "middle" and "one" used in the present specification are for clarity of description, and are not intended to limit the scope of the present application, and changes or modifications in the relative relationship may be made without substantial technical changes.
The invention is described in further detail below with reference to fig. 1-13.
The first embodiment is as follows:
as shown in fig. 1 to 13, a biochip measuring apparatus includes: the device comprises a detector 1, a detection table 2, an L-shaped frame plate 3, a sliding box body 4, a box cover 5 and a driving mechanism 6; the detector 1 is used for detecting a biochip; the detector 1 is fixedly connected to the inner side of the box cover 5; the detection table 2 is used for placing a biochip; the detector 1 is arranged opposite to the detection table 2; the detection table 2 is fixedly connected to a transverse plate of the L-shaped frame plate 3; the sliding box body 4 is in sliding fit with the outer side of the detection table 2; the top and the bottom of the sliding box body 4 are both arranged in an open manner; the box cover 5 and the sliding box body 4 are arranged up and down oppositely; the driving mechanism 6 is connected to the vertical plate of the L-shaped frame plate 3; the driving mechanism 6 is in transmission connection with the box cover 5 and the sliding box body 4 so as to drive the box cover 5 and the sliding box body 4 to be buckled or separated; the buckled box cover 5, the sliding box body 4 and the detection table 2 form a closed detection box. According to the biochip detection device, during detection, whether a closed detection box is formed or not is determined according to a biochip to be detected, when the closed detection box needs to be formed, the biochip to be detected is placed on the detection table 2, the box cover 5 and the sliding box body 4 are driven to be buckled through the driving mechanism 6, the buckled box cover 5 and the sliding box body 4 and the detection table 2 form the closed detection box, the detector 1 is started, the biochip on the detection table 2 can be detected, and the closed detection box can reduce the influence of a biochip detection result in an external environment; the detector 1 may be a CCD imaging surface scanning detector.
The second embodiment is as follows:
as shown in fig. 1 to 13, the driving mechanism 6 includes a first bidirectional screw 601, a first slider 602, a second slider 603, and an adjusting wheel 604; two ends of the first bidirectional screw 601 are rotatably matched with the upper end and the lower end of a vertical plate of the L-shaped frame plate 3; the first bidirectional screw 601 is symmetrically connected with the first sliding block 602 and the second sliding block 603 through threads; the first sliding block 602 and the second sliding block 603 are relatively and slidably fitted in longitudinal slide ways of vertical plates of the L-shaped frame plate 3; the first sliding block 602 is fixedly connected with the case cover 5; the second sliding block 603 is fixedly connected with the sliding box body 4; the first bidirectional screw 601 is fixed with the adjusting wheel 604. The driving mechanism 6 is used for controlling the relative positions of the box cover 5 and the sliding box body 4 so as to drive the box cover 5 and the sliding box body 4 to be buckled or separated; the rotation of the adjusting wheel 604 can drive the first bidirectional screw 601 to rotate around its own axis, and when the first bidirectional screw 601 rotates, the first slider 602 and the second slider 603 can be driven to move in opposite directions or away from each other, so as to drive the case cover 5 and the sliding case 4 to be buckled or separated; the buckled box cover 5, the sliding box body 4 and the detection table 2 form a closed detection box to form a closed detection environment; the separated state is shown in fig. 1 and 2, and is an unsealed detection environment in this case.
A rubber sealing gasket is arranged on the contact surface of the box cover 5 and the sliding box body 4; and a rubber sealing gasket is arranged on the contact surface of the sliding box body 4 and the detection platform 2. The arrangement of the rubber sealing gasket facilitates better sealing of the closed detection box formed by the box cover 5, the sliding box body 4 and the detection platform 2.
And an exhaust pipe with a one-way valve is arranged on the box cover 5 or the sliding box body 4, so that the gas in the closed detection box is exhausted by matching the exhaust pipe with a vacuum pump to form a vacuum detection area.
The third concrete implementation mode:
as shown in FIGS. 1 to 13, the biochip measuring apparatus further includes a light source mechanism 7; a plurality of light source mechanisms 7 are arranged, and the plurality of light source mechanisms 7 are arranged on the box cover 5 in a surrounding manner; the light source mechanism 7 comprises a laser 701, a rotary seat 702, a rotary shaft 703, a door-shaped seat 704, a worm wheel 705 and a worm 706; the laser 701 is mounted on the rotary base 702; the rotary base 702 is fixedly connected to the rotary shaft 703; the rotating shaft 703 is rotatably fitted on the portal frame 704; the door-shaped seat 704 is fixed on the inner side of the box cover 5; the worm wheel 705 is fixed on the rotating shaft 703; the worm 706 in meshing transmission connection with the worm wheel 705 is connected to the box cover 5 in a sealing and rotating way; the top of the worm 706 is fixed with a rotating head. The light source mechanism 7 is used for inducing the dye in the corresponding wave band to excite fluorescence, so that a CCD imaging surface scanning detector is convenient to detect, and the light source mechanism 7 is used for the use when the detected biochip cannot emit light; the irradiation angle of the laser 701 can be adjusted, and during adjustment, the rotating head at the top of the worm 706 is rotated, so that the worm 706 drives the worm wheel 705 to rotate, the worm wheel 705 drives the rotating shaft 703 to rotate, the rotating shaft 703 drives the rotating seat 702 to turn over, and the rotating seat 702 drives the laser 701 to adjust the irradiation angle.
The fourth concrete implementation mode:
as shown in FIGS. 1-13, the biochip measuring apparatus further includes a carrier mechanism 8; the carrier mechanism 8 comprises a bearing table 801, a bearing shaft 802, a rotary driving motor 803 with a speed reducer and a motor bracket 804; the bearing table 801 is fixedly connected to the upper end of the bearing shaft 802; the middle part of the bearing shaft 802 is in sealed rotation fit with the middle of the top surface of the detection table 2; the lower end of the bearing shaft 802 is connected with the output shaft of the rotary driving motor 803 through a coupler; the rotation driving motor 803 is connected to the horizontal plate of the bearing table 801 or the L-shaped frame plate 3 through the motor bracket 804. The bearing platform 801 of the carrier mechanism 8 is used for placing a biochip to be detected; after the rotation driving motor 803 is started, the bearing shaft 802 can be driven to rotate, and when the bearing shaft 802 rotates, the bearing table 801 can be driven to rotate, so that different positions of the biochip on the bearing table 801 can be better detected by the detector 1.
The fifth concrete implementation mode:
as shown in fig. 1-13, the motor bracket 804 includes a horizontal bracket 804A, an inclined strut 804B, a horizontal slider 804C, and a second bidirectional screw 804D; the rotary drive motor 803 is mounted on the horizontal bracket 804A; two ends of the horizontal bracket 804A are respectively and rotatably connected with one end of one inclined strut 804B, and the other ends of the two inclined struts 804B are respectively and rotatably connected with one horizontal sliding block 804C; the two horizontal sliding blocks 804C are in relative sliding fit in the horizontal slide way of the transverse plate of the L-shaped frame plate 3; two ends of the second bidirectional screw 804D are respectively and rotatably matched with two ends of a transverse plate of the L-shaped frame plate 3; the two horizontal sliding blocks 804C are symmetrically matched with the two ends of the second bidirectional screw 804D through threads. The horizontal height of the horizontal bracket 804A in the motor support 804 can be adjusted by rotating the second bidirectional screw rod 804D, the second bidirectional screw rod 804D can be rotated to drive the two horizontal sliding blocks 804C to move towards or away from the horizontal slide way of the transverse plate of the L-shaped frame plate 3, so that the included angle between the two inclined supporting rods 804B is changed, the horizontal height of the horizontal bracket 804A is driven by the two inclined supporting rods 804B to be properly adjusted, and finally, the height of the bearing table 801 is adjusted, so that the biochip on the bearing table 801 is adjusted to the optimal detection position.
The sixth specific implementation mode:
as shown in fig. 1-13, the carrier mechanism 8 further includes four chip stoppers 805; four chip stoppers 805 are connected to four sides of the platform 801; the chip stopper 805 comprises a horizontal screw 805A, an adjusting wheel 805B, a side stopper 805C and a first pressure spring 805D; four sides of the top surface of the bearing table 801 are respectively provided with a rectangular sliding chute; two ends of the horizontal screw 805A are respectively and rotatably matched with the inner end and the outer end of the rectangular sliding groove; the outer end of the horizontal screw 805A is fixedly connected with the adjusting wheel 805B; the side baffle frame 805C is connected to the horizontal screw 805A in a threaded fit manner; the side blocking frame 805C is in sliding fit in the rectangular sliding groove; the horizontal screw 805A is sleeved with the first pressure spring 805D; the first compression spring 805D is located between the side blocking frame 805C and the inner side surface of the rectangular sliding groove. The chip stopper 805 is used for properly limiting the biochip, so as to prevent the biochip from displacing when the rotary driving motor 803 is started to drive the bearing table 801 to rotate, thereby affecting the detection effect of the biochip at different positions; the rotation of the adjusting wheel 805B can drive the horizontal screw 805A to rotate, and when the horizontal screw 805A rotates, the horizontal screw 805A can drive the side blocking frame 805C to slide in the rectangular sliding groove, so as to adjust the positions of the four side blocking frames 805C of the four chip blocking pieces 805, and limit the blocking of the four sides of the biochip; the first pressure spring 805D plays a role in tensioning and limiting, and the position stability of the four side blocking frames 805C after movement is improved.
The chip stopper 805 further comprises an upper baffle 805E, a sliding screw 805F, a limit nut 805G, a second pressure spring 805H and a tray 805I; an upper slideway and a lower slideway are arranged on the side blocking frame 805C; the middle part of the sliding screw 805F is in sliding fit with the upper end of the side baffle frame 805C; the bottom end of the sliding screw 805F is connected with the tray 805I in a rotating fit manner; the bottom surface inside the upper and lower slide ways is provided with a containing groove matched with the tray 805I; the upper baffle 805E is slidably fitted over the sliding screw 805F; the tray 805I is blocked at the lower end of the upper blocking plate 805E; the second pressure spring 805H is sleeved on the sliding screw 805F between the upper baffle 805E and the top surfaces of the upper and lower slideways; the upper baffle 805E is in sliding fit in the upper and lower slideways; the inner end of the upper baffle 805E penetrates out of the side baffle 805C; the sliding screw 805F is connected with the limit nut 805G through thread fit; the stop nut 805G is retained on the top surface of the side-stop 805C. The upper plate 805E is used to block and limit the upper ends of the side ends of the biochips, and the second compression spring 805H is provided to adapt to the use of biochips with different thicknesses, and the position of the limiting nut 805G and the sliding screw 805F can be changed by rotating the limiting nut 805G, thereby adjusting the lowest position of the upper plate 805E.
The seventh embodiment:
as shown in fig. 1-13, the carrier mechanism 8 further includes a flight adjustment assembly 806; the catch adjustment assembly 806 includes a friction drive ring 806A, a stud 806B, a rotation ring 806C, and a toggle plate 806D; the friction driving ring 806A is vertically connected with the adjusting wheel 805B of the chip stopper 805 in a friction driving manner; the bottom surface of the friction drive ring 806A is fixed on the rotating ring 806C by a plurality of evenly surrounding studs 806B; the rotating ring 806C is rotatably fitted in an annular groove in the middle of the bearing platform 801; the outer end of the friction drive ring 806A is fixedly connected to the toggle plate 806D. The carrier mechanism 8 further includes a flight adjustment assembly 806; the stopper adjusting assembly 806 is used for controlling the four chip stoppers 805 to be adjusted synchronously; the poking plate 806D is poked to drive the friction transmission ring 806A to rotate around the axis of the friction transmission ring 806A, the friction transmission ring 806A drives the rotation ring 806C to rotate and move around in the annular groove in the middle of the bearing platform 801 through the short column 806B, and when the friction transmission ring 806A rotates, the four adjusting wheels 805B of the four chip stoppers 805 are driven to rotate through friction transmission, so that the positions of the four side stopper frames 805C are synchronously adjusted.
The principle is as follows: according to the biochip detection device, during detection, whether a closed detection box is formed or not is determined according to a biochip to be detected, when the closed detection box needs to be formed, the biochip to be detected is placed on the detection table 2, the box cover 5 and the sliding box body 4 are driven to be buckled through the driving mechanism 6, the buckled box cover 5 and the sliding box body 4 and the detection table 2 form the closed detection box, the detector 1 is started, the biochip on the detection table 2 can be detected, and the closed detection box can reduce the influence of a biochip detection result in an external environment; the detector 1 may be a CCD imaging surface scanning detector.
The embodiments are described in a progressive manner in the specification, each embodiment focuses on differences from other embodiments, and the same and similar parts among the embodiments are referred to each other. It should be noted that, for those skilled in the art, it is possible to make several improvements and modifications to the present application without departing from the principle of the present application, and such improvements and modifications also fall within the scope of the claims of the present application.
It is further noted that, in the present specification, relational terms such as first and second, and the like are used solely to distinguish one entity or action from another entity or action without necessarily requiring or implying any actual such relationship or order between such entities or actions. Also, the terms "comprises," "comprising," or any other variation thereof, are intended to cover a non-exclusive inclusion, such that a process, method, article, or apparatus that comprises a list of elements does not include only those elements but may include other elements not expressly listed or inherent to such process, method, article, or apparatus. Without further limitation, an element defined by the phrase "comprising an … …" does not exclude the presence of other identical elements in a process, method, article, or apparatus that comprises the element.
Claims (10)
1. A biochip measuring apparatus, comprising: the device comprises a detector (1), a detection table (2), an L-shaped frame plate (3), a sliding box body (4), a box cover (5) and a driving mechanism (6); the detector (1) is used for detecting a biochip; the detector (1) is fixedly connected to the inner side of the box cover (5); the detection table (2) is used for placing a biochip; the detector (1) is arranged opposite to the detection table (2); the detection table (2) is fixedly connected to a transverse plate of the L-shaped frame plate (3); the sliding box body (4) is in sliding fit with the outer side of the detection table (2); the top and the bottom of the sliding box body (4) are arranged in an open manner; the box cover (5) and the sliding box body (4) are arranged oppositely up and down; the driving mechanism (6) is connected to a vertical plate of the L-shaped frame plate (3); the driving mechanism (6) is in transmission connection with the box cover (5) and the sliding box body (4) so as to drive the box cover (5) and the sliding box body (4) to be buckled or separated; the buckled box cover (5) and the sliding box body (4) form a closed detection box with the detection table (2).
2. The device for detecting the biochip according to claim 1, wherein the driving mechanism (6) comprises a first bidirectional screw (601), a first slider (602), a second slider (603), and an adjustment wheel (604); two ends of the first bidirectional screw rod (601) are rotatably matched with the upper end and the lower end of a vertical plate of the L-shaped frame plate (3); the first bidirectional screw (601) is symmetrically connected with the first sliding block (602) and the second sliding block (603) through threads; the first sliding block (602) and the second sliding block (603) are relatively matched in a longitudinal slide way of a vertical plate of the L-shaped frame plate (3) in a sliding way; the first sliding block (602) is fixedly connected with the box cover (5); the second sliding block (603) is fixedly connected with the sliding box body (4); the adjusting rotating wheel (604) is fixed on the first bidirectional screw rod (601).
3. The biochip detecting apparatus according to claim 2, wherein a rubber gasket is provided on the contact surface of the cover (5) and the sliding case (4); and a rubber sealing gasket is arranged on the contact surface of the sliding box body (4) and the detection platform (2).
4. The device for detecting the biochip according to claim 3, wherein the lid (5) or the sliding box (4) is provided with a suction tube having a check valve, so that the suction tube cooperates with a vacuum pump to draw out the gas inside the closed detection box, thereby forming a vacuum detection area.
5. The device for detecting a biochip according to claim 2, further comprising a light source mechanism (7); a plurality of light source mechanisms (7) are arranged, and the plurality of light source mechanisms (7) are arranged on the box cover (5) in a surrounding manner; the light source mechanism (7) comprises a laser (701), a rotating seat (702), a rotating shaft (703), a door-shaped seat (704), a worm wheel (705) and a worm (706); the laser (701) is mounted on the rotary base (702); the rotating base (702) is fixedly connected to the rotating shaft (703); the rotating shaft (703) is rotationally matched on the door-shaped seat (704); the door-shaped seat (704) is fixed on the inner side of the box cover (5); the worm wheel (705) is fixed on the rotating shaft (703); the worm (706) in meshed transmission connection with the worm wheel (705) is connected to the box cover (5) in a sealing and rotating way; the top of the worm (706) is fixed with a rotating head.
6. The device for detecting a biochip according to claim 5, further comprising a carrier mechanism (8); the carrier mechanism (8) comprises a bearing table (801), a bearing shaft (802), a rotary driving motor (803) with a speed reducer and a motor bracket (804); the bearing table (801) is fixedly connected to the upper end of the bearing shaft (802); the middle part of the bearing shaft (802) is in sealed rotating fit with the middle of the top surface of the detection table (2); the lower end of the bearing shaft (802) is connected with an output shaft of the rotary driving motor (803) through a coupler; the rotary driving motor (803) is connected to the horizontal plate of the bearing platform (801) or the L-shaped frame plate (3) through the motor bracket (804).
7. The device of claim 6, wherein the motor support (804) comprises a horizontal bracket (804A), a tilted support rod (804B), a horizontal slider (804C) and a second bidirectional screw (804D); the rotary drive motor (803) is mounted on the horizontal bracket (804A); two ends of the horizontal bracket (804A) are respectively and rotatably connected with one end of one inclined strut (804B), and the other ends of the two inclined struts (804B) are respectively and rotatably connected with one horizontal sliding block (804C); the two horizontal sliding blocks (804C) are in relative sliding fit in horizontal slideways of transverse plates of the L-shaped frame plate (3); two ends of the second bidirectional screw (804D) are respectively and rotatably matched with two ends of a transverse plate of the L-shaped frame plate (3); the two horizontal sliding blocks (804C) are symmetrically matched at two ends of the second bidirectional screw rod (804D) through threads.
8. The device according to claim 6, wherein the carrier mechanism (8) further comprises four chip stoppers (805); four chip stoppers (805) are connected to four sides of the bearing table (801); the chip blocking piece (805) comprises a horizontal screw (805A), an adjusting wheel (805B), a side blocking frame (805C) and a first pressure spring (805D); four sides of the top surface of the bearing table (801) are respectively provided with a rectangular sliding chute; two ends of the horizontal screw (805A) are respectively and rotatably matched at the inner end and the outer end of the rectangular sliding groove; the outer end of the horizontal screw (805A) is fixedly connected with the adjusting wheel (805B); the side baffle frame (805C) is connected to the horizontal screw rod (805A) in a threaded fit manner; the side baffle frame (805C) is in sliding fit in the rectangular sliding groove; the horizontal screw (805A) is sleeved with the first pressure spring (805D); the first pressure spring (805D) is located between the side blocking frame (805C) and the inner side face of the rectangular sliding groove.
9. The device for detecting biochip according to claim 8, wherein the chip stopper (805) further comprises an upper stopper (805E), a sliding screw (805F), a limit nut (805G), a second compression spring (805H), and a tray (805I); an upper slideway and a lower slideway are arranged on the side baffle frame (805C); the middle part of the sliding screw (805F) is in sliding fit with the upper end of the side baffle frame (805C); the bottom end of the sliding screw (805F) is connected with the tray (805I) in a rotating fit manner; the bottom surface inside the upper and lower slide ways is provided with a containing groove matched with the tray (805I); the upper baffle (805E) is in sliding fit on the sliding screw (805F); the tray (805I) is blocked at the lower end of the upper baffle plate (805E); the sliding screw (805F) between the upper baffle (805E) and the top surfaces of the upper and lower slideways is sleeved with the second pressure spring (805H); the upper baffle (805E) is in sliding fit in the upper and lower slideways; the inner end of the upper baffle plate (805E) penetrates out of the side baffle frame (805C); the sliding screw (805F) is connected with the limit nut (805G) through thread fit; the limiting nut (805G) is blocked on the top surface of the side blocking frame (805C).
10. The device for detecting biological chips as claimed in claim 9, wherein said carrier mechanism (8) further comprises a stopper adjusting assembly (806); the catch adjustment assembly (806) includes a friction drive ring (806A), a stud (806B), a rotation ring (806C), and a toggle plate (806D); the friction drive ring (806A) is vertically in friction drive connection with the adjusting wheel (805B) of the chip stopper (805); the bottom surface of the friction transmission ring (806A) is fixed on the rotating ring (806C) through a plurality of uniformly surrounding short columns (806B); the rotating ring (806C) is rotatably matched in an annular groove in the middle of the bearing platform (801); the outer end of the friction transmission ring (806A) is fixedly connected with the poking plate (806D).
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| CN113000080A (en) * | 2021-02-19 | 2021-06-22 | 北京京东方健康科技有限公司 | Detecting instrument |
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Effective date of registration: 20211203 Address after: 200120 2nd floor, building 13, 27 Xinjinqiao Road, China (Shanghai) pilot Free Trade Zone, Pudong New Area, Shanghai Applicant after: Shanghai Tanshi Biotechnology Co.,Ltd. Address before: 226500 room 702, building A6, science and Innovation Park, No. 20, Huashi North Road, Chengbei street, Rugao City, Nantong City, Jiangsu Province Applicant before: Cao Xiulin |