CN111616968A

CN111616968A - Composition for Guifu ointment and preparation method, use method and application thereof

Info

Publication number: CN111616968A
Application number: CN202010520595.9A
Authority: CN
Inventors: 陆一仁; 程伟峰; 胡新成
Original assignee: Shanghai Zhong Yi Daily Chemical Co ltd
Current assignee: Shanghai Zhong Yi Daily Chemical Co ltd
Priority date: 2020-06-10
Filing date: 2020-06-10
Publication date: 2020-09-04
Anticipated expiration: 2040-06-10
Also published as: CN111616968B

Abstract

The invention provides a composition for a pregnant woman ointment, which comprises the following components: an aqueous phase containing at least natural equivalents; and an oil phase containing at least a silicone elastomer; and when the component further comprises grafted starch, the phases form a macroscopically homogeneous mixture therein. The composition and the product thereof have stronger high-temperature stability and can adapt to the conditions of hot seasons, high-temperature transportation environments and the like.

Description

Composition for Guifu ointment and preparation method, use method and application thereof

Technical Field

The invention relates to the field of skin care products, in particular to a paste composition.

Background

The cream skin care product is a durable product in the field of skin care products, and particularly, a large variety of products appear at present: ointment for treating women.

The Guifu cream is a large class of cosmetics which are rapidly raised, is a daily necessity for daily life of people, has the skin care function of common cream, and can also provide the effects of primarily making up to cover blemishes, priming before making up and the like. With the increasing functional requirements of consumers on cream and pre-makeup milk, the characteristic types of the pregnant cream and the like gradually become popular. The Guifu ointment is an emerging class, and is increasingly popular with consumers because the Guifu ointment can provide novel use feeling for the consumers due to unique appearance and texture and has multiple compound effect.

The Guifu ointment is prepared by emulsifying water phase and oil phase with emulsifier to form homogeneous phase. The existing commercial products are unstable in a high-temperature environment, and are easy to demulsify, produce oil and produce water; similar conditions can occur even after long-term storage (normal temperature over 3 months). Therefore, the power of the factory is low in the configuration process, which results in higher cost and serious product waste.

Disclosure of Invention

The invention provides a composition for a pregnant woman ointment, which comprises the following components:

an aqueous phase containing at least natural equivalents; and

an oil phase containing at least a silicone elastomer; and

when the component also comprises grafted starch, the phases form a macroscopically homogeneous mixture therein.

As one embodiment of the present invention, the composition for a pregnant woman cream is used for skin care.

As one embodiment of the present invention, the cosmetic composition further comprises a skin care efficacy ingredient.

A process for preparing a skin care composition, said process comprising at least one step of mixing under conditions suitable to obtain a macroscopically homogeneous mixture:

an aqueous phase containing at least natural equivalents; and

an oil phase containing at least a silicone elastomer; and

the aqueous phase and the oil phase are mixed in the presence of grafted starch.

A non-therapeutic cosmetic method for treating the skin, comprising at least one step of applying to the skin a composition for treating the skin comprising: an aqueous phase containing at least natural equivalents; and

an oil phase containing at least a silicone elastomer; and

when the preparation raw material also contains grafted starch, the phases form a macroscopically homogeneous mixture therein.

A non-therapeutic cosmetic method for caring for the skin, comprising at least the application to the material of a macroscopically homogeneous composition by extemporaneous mixing, before application or at the time of application to the skin, of a composition for a precious woman cream according to claim 1.

As an embodiment of the present invention, the raw material of the grafted starch comprises starch, and the amylopectin content in the starch is greater than 79%.

As an embodiment of the present invention, the grafted starch is sodium polyacrylate grafted starch.

As an embodiment of the invention, the composition further comprises a polysiloxane and polyglycerol-3-methylglucose distearate.

In one embodiment of the present invention, the mass ratio of the polyglycerin-3-methylglucose distearate to the grafted starch is (1 to 5): (0.05-3).

Has the advantages that: the composition and the product thereof have stronger high-temperature stability and can adapt to the conditions of hot seasons, high-temperature transportation environments and the like.

Drawings

FIG. 1: example 1 and comparative example 1 appearance before high temperature stability test

FIG. 2: example 1 and comparative example 1 appearance after high temperature stability test

Detailed Description

The disclosure may be understood more readily by reference to the following detailed description of preferred embodiments of the invention and the examples included therein. Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs. In case of conflict, the present specification, including definitions, will control.

The term "prepared from …" as used herein is synonymous with "comprising". The terms "comprises," "comprising," "includes," "including," "has," "having," "contains," "containing," or any other variation thereof, as used herein, are intended to cover a non-exclusive inclusion. For example, a composition, process, method, article, or apparatus that comprises a list of elements is not necessarily limited to only those elements but may include other elements not expressly listed or inherent to such composition, process, method, article, or apparatus.

The conjunction "consisting of …" excludes any unspecified elements, steps or components. If used in a claim, the phrase is intended to claim as closed, meaning that it does not contain materials other than those described, except for the conventional impurities associated therewith. When the phrase "consisting of …" appears in a clause of the subject matter of the claims rather than immediately after the subject matter, it defines only the elements described in the clause; other elements are not excluded from the claims as a whole.

When an amount, concentration, or other value or parameter is expressed as a range, preferred range, or as a range of upper preferable values and lower preferable values, this is to be understood as specifically disclosing all ranges formed from any pair of any upper range limit or preferred value and any lower range limit or preferred value, regardless of whether ranges are separately disclosed. For example, when a range of "1 to 5" is disclosed, the described range should be interpreted to include the ranges "1 to 4", "1 to 3", "1 to 2 and 4 to 5", "1 to 3 and 5", and the like. When a range of values is described herein, unless otherwise stated, the range is intended to include the endpoints thereof and all integers and fractions within the range.

The singular forms "a", "an" and "the" include plural referents unless the context clearly dictates otherwise. "optional" or "any" means that the subsequently described event or events may or may not occur, and that the description includes instances where the event occurs and instances where it does not.

Approximating language, as used herein throughout the specification and claims, is intended to modify a quantity, such that the invention is not limited to the specific quantity, but includes portions that are literally received for modification without substantial change in the basic function to which the invention is related. Accordingly, the use of "about" to modify a numerical value means that the invention is not limited to the precise value. In some instances, the approximating language may correspond to the precision of an instrument for measuring the value. In the present description and claims, range limitations may be combined and/or interchanged, including all sub-ranges contained therein if not otherwise stated.

In addition, the indefinite articles "a" and "an" preceding an element or component of the invention are not intended to limit the number requirement (i.e., the number of occurrences) of the element or component. Thus, "a" or "an" should be read to include one or at least one, and the singular form of an element or component also includes the plural unless the stated number clearly indicates that the singular form is intended.

The composition for the Guifu ointment is characterized by comprising the following components:

an aqueous phase containing at least natural equivalents; and

an oil phase containing at least a silicone elastomer; and

Aqueous phase

The aqueous phase described in the present invention contains natural equivalents.

The natural product equivalent refers to a substance prepared by a synthetic method or a substance obtained by chemical processing from natural raw materials, and has a chemical structure and properties equivalent to those of a substance existing in a natural product.

The natural equivalent in the invention is a natural equivalent with moisture absorption function, and can be selected from but not limited to betaine.

In the present invention, the aqueous phase further comprises a humectant.

The humectant is selected from one or more of polyalcohol, polyethylene glycol, polysaccharide, panthenol and sodium hyaluronate.

The polyol is preferably a polyol having less than 10 carbon atoms from the viewpoint of improving the stability of the product; and is further selected from one or more of glycerol, 1, 3-butanediol and caprylyl glycol.

From the viewpoint of improving the thermodynamic stability of the product, the humectant further includes ethylhexylglycerin.

Oil phase

The oil phase in the present invention contains a silicone elastomer.

The organic silicon elastomer is selected from one or more of vinyl polydimethylsiloxane/polymethylsiloxane silsesquioxane cross-linked polymer, polymethyl methacrylate, polydimethylsiloxane cross-linked polymer, polysiloxane-11 and cetearyl polydimethylsiloxane cross-linked polymer.

As an embodiment of the present invention, the silicone elastomer is selected from one or more of polydimethylsiloxane, vinyl polydimethylsiloxane/polymethylsiloxane silsesquioxane crosspolymer, polydimethylsiloxane/vinyl polydimethylsiloxane crosspolymer.

In the present invention, the oil phase further comprises a liquid emollient oil and/or a solid oil wax.

The liquid emollient oils include, but are not limited to, one or more of cyclopentadimethylsiloxane, polydimethylsiloxane, isotridecanol isononanoate, tridecyl trimellitate, tocopheryl acetate, isononyl isononanoate, phenyl trimethicone, isodecyl neopentanoate, ethylhexyl methoxycinnamate, and the like.

The solid oil wax includes one or more of C10-18 triglyceride esters, beeswax, microcrystalline wax, cetearyl alcohol, jojoba esters, and PEG stearate.

From the standpoint of improving the stability of the product, the oil phase also includes stabilizers including, but not limited to, one or more of polyglyceryl-3 methyl glucose distearate, polyglyceryl-3/jojoba esters, glyceryl stearate, PEG-100 stearate, cellulose, xanthan gum, carbomers, disteardimonium hectorite.

The rest components

The present invention provides components in which the aqueous phase and the oil phase can form a macroscopically homogeneous mixture in the presence of grafted starch.

In the invention, the grafted starch is sodium polyacrylate grafted starch, the macroscopically long-term uniformity of the composition is improved, and the content of amylopectin in the starch is more than 79%.

In the invention, the sodium polyacrylate grafted starch is prepared by any method known to those skilled in the art, and starch is preferably gelatinized and then added with an acrylic acid monomer aqueous solution and an initiator; and (3) adding a sodium hydroxide aqueous solution after the reaction is finished, thereby obtaining the sodium polyacrylate grafted starch.

According to the invention, when the acrylic acid monomer aqueous solution is prepared by the method, the effect is optimal when the neutralization degree of the adopted acrylic acid monomer aqueous solution is 83%, and the mass ratio of starch to acrylic acid is 1: the best effect is achieved at 2.6.

The composition for the Guifu ointment further comprises polysiloxane as a component capable of assisting in grafting starch; in one embodiment of the present invention, the polysiloxane is preferably polydimethylsiloxane.

As a preferred mode of the invention, the composition for the pregnant woman cream further comprises a skin-care functional ingredient.

The skin care functional components are selected from some functional components in the field of skin care products such as whitening components, moisturizing components, wrinkle removing components, freckle lightening components, fine wrinkle lightening components and the like.

In a preferred embodiment of the present invention, the skin care functional ingredient is one or more selected from the group consisting of enzyme-cleaved oligomeric hyaluronic acid sodium, nicotinamide, fullerene HA solution, carnosine, cordyceps sinensis extract, bird's nest extract, and hydrolyzed procyanidin.

A second aspect of the invention provides a process for preparing a skin care composition, said process comprising at least one step of mixing, under conditions suitable to obtain a macroscopically homogeneous mixture:

an aqueous phase containing at least natural equivalents; and

an oil phase containing at least a silicone elastomer; and

A third aspect of the invention provides a non-therapeutic cosmetic method for treating the skin, comprising at least one step of applying to the skin a composition for treating the skin comprising: an aqueous phase containing at least natural equivalents; and

an oil phase containing at least a silicone elastomer; and

A fourth aspect of the invention provides a non-therapeutic cosmetic method for caring for the skin, comprising at least the application to the material of a macroscopically homogeneous composition by extemporaneous mixing, before application or at the time of application to the skin, of a composition for a banking up woman according to claim 1.

The fifth aspect of the invention provides a cream-like skin care product, which is prepared by the following steps:

1) sequentially adding the water phase raw materials into a water phase pot, stirring and heating to 80-85 ℃, stirring until the water phase is clear and transparent, and keeping the temperature for 30 minutes;

2) sequentially adding the oil phase raw materials into an emulsifying pot, stirring and heating to 80-85 ℃, stirring and dispersing until the material body is uniform (proper homogenization can be carried out, and a three-roller machine or a colloid mill can be used if necessary);

3) adding the water phase pot body into an emulsifying pot under the mean value condition, slowly pumping into the emulsifying pot, and homogenizing at high speed for 5-10 minutes;

4) adding the pre-mixed grafted starch and polysiloxane into an emulsifying pot, and continuing homogenizing for 3 minutes;

5) slowly stirring and cooling to 40 ℃, and adding the mixed residual substances;

6) and continuously stirring and cooling until the material body is uniform and cooled to 35 ℃, discharging and finishing the preparation.

The composition for the pregnant woman ointment provided by the invention is prepared into an ointment product, and the ointment product can be stored at room temperature or at high temperature for a long time; the reason for this is because the product prepared by the present invention is an oil-in-water mixture; the sodium polyacrylate grafted starch provided by the invention can form an oil-in-water system with smaller particle size; meanwhile, according to the Gibbs-Marangnoi effect, the thermodynamics of the film of the system is stable. The invention adopts the sodium polyacrylate grafted starch, and simultaneously adds the polyalcohol with the carbon chain less than 10 into the water phase; the polyol not only can reduce the interfacial tension; meanwhile, the rigidity of the interface can be weakened, so that an interface tension gradient is formed, and the stability is enhanced.

Meanwhile, according to the principle of instantaneous negative interfacial tension, the polysiloxane and the substances in the oil phase can provide interfacial viscosity, and the high-viscosity interface hinders the exchange displacement between oil-in-water particles; at the same time, even if a negative interfacial tension is generated at a certain moment, the product can still return to a macroscopically homogeneous mixture even after a short separation under the action of centrifugal force.

The present invention will be described in detail with reference to specific examples.

Example 1:

in the above-mentioned preparation of the raw materials,

the cordyceps sinensis extract is purchased from Xianweite biotechnology limited liability company, and the cubilose extract is sold in the market; the essence is common essence in the field of skin care products, and is not limited at all.

In the preparation raw materials, the preparation process of the sodium polyacrylate grafted starch comprises the following steps:

dissolving a certain amount of starch in deionized water, adding a certain amount of NaOH solution for gelatinization for 25 minutes, taking an acrylic acid monomer aqueous solution with the neutralization degree of 83%, slowly adding the acrylic acid monomer aqueous solution into the gelatinized starch, and adding an initiator under stirring. And (3) placing the reaction solution in a microwave reactor, and reacting for 2 hours to generate a dry product.

A certain amount of the crude product was extracted with a glacial acetic acid/ethylene glycol (volume ratio 2:3) mixture for 10h in a Soxhlet extractor to remove the homopolymer.

Adding a certain amount of NaOH solution into the product, stirring for 1h at 50 ℃ to dissolve unreacted native starch, filtering the grafted product by using a Buchner funnel, and drying to obtain the pure grafted copolymer.

Wherein the amylopectin content of the starch is greater than 79 wt%, and between about 80-85 wt%; the mass ratio of the starch to the acrylic acid monomer is 1: 2.6; the mass fraction of the sodium hydroxide solution is 25 percent; the initiator is ammonium persulfate, and the concentration of the initiator is 0.01 mol/L.

The embodiment provides a skin care cream product, which is prepared from the components, and the preparation process comprises the following steps:

4) adding the grafted starch phase material which is premixed in advance into an emulsifying pot, and continuing homogenizing for 3 minutes;

5) slowly stirring, cooling to 40 deg.C, and adding skin care effective component phase raw material;

Example 2: the difference from example 1 is that the neutralization degree of the acrylic acid monomer solution was 85%.

Example 3: the difference from example 1 is that the neutralization degree of the acrylic acid monomer solution was 78%.

Example 4: the difference from example 1 is that the mass ratio of starch to acrylic acid monomer is 1: 2.

example 5: the difference from example 1 is that the mass ratio of starch to acrylic acid monomer is 1: 3.

example 6: the difference from example 1 is that the amylopectin content of the starch is more than 85 wt.%.

Example 7: the difference from example 1 is that the amylopectin content of the starch is less than 70 wt.%.

Example 8: the difference from example 1 is that the grafted starch phase does not contain polydimethylsiloxane.

Example 9: the difference from example 1 is that 1, 3-butanediol in the aqueous phase is replaced by an equal mass fraction of 1, 9-nonanediol.

Example 10: the difference from example 1 is that the sunflower seed wax is replaced by the same mass fraction of polyglycerol-3 in the oil phase.

Comparative example 1: a certain amount of Guifu ointment purchased in the market.

And (3) performance testing:

test 1. the products of examples 1 to 10 and comparative example 1 were centrifuged in a centrifuge and then left to stand at room temperature for 24 hours to see if they were a homogeneous mixture. Wherein the speed of the centrifuge is 80r/min, and the centrifuge lasts 20 s.

The method comprises the following steps: is a homogeneous mixture; otherwise: is not a homogeneous mixture

Test 2. high temperature stability test: the products of examples 1 to 10 and comparative example 1 were allowed to stand at a high temperature of 40 ℃ for 1 month to check whether the mixture was homogeneous or not and whether an oil-water separation phenomenon occurred.

The method comprises the following steps: the oil-water separation phenomenon occurs; otherwise: the oil-water separation phenomenon does not occur

The foregoing examples are merely illustrative and serve to explain some of the features of the method of the present invention. The appended claims are intended to claim as broad a scope as is contemplated, and the examples presented herein are merely illustrative of selected implementations in accordance with all possible combinations of examples. Accordingly, it is applicants' intention that the appended claims are not to be limited by the choice of examples illustrating features of the invention. Also, where numerical ranges are used in the claims, subranges therein are included, and variations in these ranges are also to be construed as possible being covered by the appended claims.

Claims

1. The composition for the Guifu ointment is characterized by comprising the following components:

an aqueous phase containing at least natural equivalents; and

an oil phase containing at least a silicone elastomer; and

2. The composition for a pregnant woman cream according to claim 1, wherein the composition is used for skin care.

3. The composition for a pregnant woman cream according to claim 1, wherein the cosmetic composition further comprises a skin care effect ingredient.

4. A process for preparing a skin care composition, characterized in that it comprises at least one step of mixing, under conditions suitable to obtain a macroscopically homogeneous mixture:

an aqueous phase containing at least natural equivalents; and

an oil phase containing at least a silicone elastomer; and

5. A non-therapeutic cosmetic process for treating the skin, characterized in that it comprises at least one step of applying to the skin a composition for treating the skin comprising: an aqueous phase containing at least natural equivalents; and

an oil phase containing at least a silicone elastomer; and

6. A non-therapeutic cosmetic process for caring for the skin, characterized in that it comprises at least the application to said material of a macroscopically homogeneous composition, by extemporaneous mixing of the composition for noble woman's cream according to claim 1, before application or during application to the skin.

7. The composition for the noble plaster of any one of claims 1 to 3, wherein the raw material of the grafted starch comprises starch, and the content of amylopectin in the starch is more than 79%.

8. The composition for the ointment for women, according to any one of claims 1 to 3, wherein the grafted starch is a sodium polyacrylate grafted starch.

9. The composition for the cream of women's beauty according to any one of claims 1 to 3, characterized by further comprising silicone and polyglycerin-3-methylglucose distearate.

10. The composition for the pregnant cream according to claim 9, wherein the mass ratio of the polyglycerin-3-methylglucose distearate to the grafted starch is (1-5): (0.05-3).