CN111603480A

CN111603480A - Nasal wash

Info

Publication number: CN111603480A
Application number: CN202010627735.2A
Authority: CN
Inventors: 王浏胜
Original assignee: Individual
Current assignee: Individual
Priority date: 2020-07-02
Filing date: 2020-07-02
Publication date: 2020-09-01

Abstract

The invention provides a nasal wash, which relates to a medical health care product, and comprises sodium chloride, N-acetylneuraminic acid, chlorogenic acid, betaine and menthol, wherein the N-acetylneuraminic acid is beneficial to keeping the humidity of a nasal cavity; the N-acetylneuraminic acid is used as a receptor of the pathogen, and can effectively prevent the pathogen from being combined with host cells; chlorogenic acid can be combined with neuraminidase to inhibit neuraminidase activity and prevent sialic acid at the tail end of a receptor from being hydrolyzed, so that pathogens are prevented from being combined with host cells, and the chlorogenic acid has antiviral and antibacterial functions; the betaine has moisturizing effect, and the quaternary ammonium salt structure ensures that the betaine has certain antiviral effect; the menthol has special fragrance, can stimulate nostrils, enables the nasal cavity to be smoother, and simultaneously kills partial pathogens, so that the nasal cleanser has the effects of cleaning the nasal cavity, resisting viruses, nasal obstruction, nasal itching and nasal dryness, reducing upper respiratory tract infection and reducing the number of sick days.

Description

Nasal wash

Technical Field

The invention relates to a medical health care product, in particular to a nasal wash.

Background

The pathogens of cold are complex and various, and various viruses, mycoplasma and bacteria can cause cold, and the cold mainly comprises rhinovirus, coronavirus, parainfluenza virus and the like. In particular, more than 100 rhinoviruses cause colds, and studies have shown that 80% of acute upper respiratory infections are caused by rhinoviruses. The cold sufferers usually have nasal discomfort symptoms such as nasal obstruction, running nose and the like.

Influenza, referred to as influenza for short, is an acute respiratory infectious disease caused by influenza virus, and seriously harms the health of people. Compared with the common cold, the influenza has the characteristics of variable virus antigenicity and rapid transmission, seasonal epidemics can be caused every year, and outbreak epidemic situations can occur in places where people gather. Data published in the chinese guidelines for influenza vaccination (2019-2020) show: seasonal epidemics of influenza annually can lead to 300 to 500 million severe cases worldwide, with 29 to 65 million respiratory disease-related deaths; the prevalence rate of influenza in the whole Chinese population is 10.7%, and 8.8 million influenza-related respiratory diseases die in excess every year in the 10-11 to 14-15 seasons. Furthermore, the economic burden of influenza is also high: research shows that the direct medical cost of influenza outpatient cases in China is 156-595 yuan per person, and the indirect cost is 198-366 yuan per person; the economic burden of influenza hospitalization is more than 10 times that of outpatient cases.

Since pathogens of the cold and flu invade the human respiratory tract primarily through the nasal cavity, the nasal cavity is the first line of defense against pathogens invading the human body. Preventing pathogens from entering the nasal cavity and cleaning the nasal cavity are both ways to prevent colds and flu. For patients already suffering from a cold or flu, it is also beneficial to keep the nasal cavity clean for recovery as soon as possible.

Currently, there are more and more patients suffering from nasal discomfort, and in view of this, nasal wash products have been developed. Most of the commercial circulating nasal irrigation products are solid nasal irrigation salts which are not dissolved in advance or spray which is dissolved well, and can be used for relieving nasal discomfort. Although the nasal wash products have various brands, the main component is sodium chloride, and the nasal wash cannot resist pathogenic bacteria and viruses. Through retrieval, the nasal wash products for resisting the invasion of viruses, pathogenic bacteria and the like in the market are few in types.

Disclosure of Invention

The invention aims to solve the technical problem of overcoming the defects in the prior art and provides a nasal wash which has the functions of moistening the nasal cavity, relieving the uncomfortable feeling of the nasal cavity, resisting the invasion of viruses, germs and the like and further effectively avoiding the induction of upper respiratory tract infection.

The invention is realized by the following technical scheme: a nasal wash comprises sodium chloride, N-acetylneuraminic acid, chlorogenic acid, betaine and menthol.

According to the technical scheme, the compound preparation preferably comprises 1-15mg/mL of sodium chloride, 0.5-10mg/mL of N-acetylneuraminic acid, 0.5-5mg/mL of chlorogenic acid, 0.5-5mg/mL of betaine, 0.05-0.5mg/mL of menthol and the balance of purified water.

According to the technical scheme, the compound preparation preferably comprises 7-12mg/mL of sodium chloride, 0.5-5mg/mL of N-acetylneuraminic acid, 0.5-2mg/mL of chlorogenic acid, 0.5-2mg/mL of betaine, 0.05-0.2mg/mL of menthol and the balance of purified water.

According to the technical scheme, the compound preparation preferably comprises 10mg/mL of sodium chloride, 1mg/mL of N-acetylneuraminic acid, 1mg/mL of chlorogenic acid, 1mg/mL of betaine, 0.1mg/mL of menthol and the balance of purified water.

According to the technical scheme, the nose washing agent is preferably clear and transparent liquid medicine without sediment.

According to the technical scheme, preferably, the nasal wash is filled in the spray bottle and is matched with the spray bottle for use.

According to the technical scheme, the pH value of the nasal wash is preferably 2.5-5.5.

According to the above technical solution, preferably, the nasal wash is used for inhibiting or treating upper respiratory diseases, inhibiting or treating upper respiratory viral infections.

According to the above technical solution, preferably, the respiratory tract diseases include symptoms of dry nose, itching and/or common cold and/or rhinovirus infection.

N-acetylneuraminic acid with the molecular formula of C11H19NO9 is white powder; n-acetylneuraminic acid contains hydrophilic carboxyl, glyceryl and other groups, and is helpful for moisturizing; in addition, N-acetylneuraminic acid can resist oxidation and inhibit cell death caused by hydrogen peroxide; can promote synapse formation and improve intelligence development of children; can assist T lymphocyte transformation and enhance immunity; n-acetylneuraminic acid has also been found to be closely related to influenza: the influenza virus surface expression neuraminidase can catalyze N-acetylneuraminic acid hydrolysis, and has important effects on maintaining the normal life cycle of the influenza virus and the propagation in a host body; current studies indicate that most pathogens use N-acetylneuraminic acid as a receptor; the additional N-acetylneuraminic acid can possibly act as a pseudo receptor, so that the virus cannot be combined with host cells, and the virus can be prevented from invading the human body.

Chlorogenic acid, molecular formula of C11H19NO9, is a white powder; chlorogenic acid is widely existed in plants, especially important honeysuckle and eucommia ulmoides, and the main effective component of the chlorogenic acid is the chlorogenic acid; at present, a plurality of experiments prove that chlorogenic acid has good antibacterial and antiviral activity, and the chlorogenic acid is reported to be one of effective components for resisting influenza viruses in documents; in addition, the enzyme inhibition experiments prove that the chlorogenic acid has the neuraminidase inhibition activity, and the neuraminidase is a substance which plays an important role in the process that the virus enters cells and spreads in a host body.

Betaine is an alkaloid commonly existing in animals and plants, has a molecular formula of C5H11NO2, and is a white powder; the betaine has strong hygroscopicity, easy deliquescence and strong moisturizing effect; in addition, betaine has low skin irritation and excellent detergency and bactericidal efficacy, and is therefore frequently used as an antibacterial agent.

The menthol crystal is white needle crystal extracted from stem or leaf of herba Menthae, has special smell, is cool after initial scorching, and has effect of stimulating resuscitation; the important compound for treating rhinitis, which is described in Chinese patent CN1951433A, contains menthol.

The invention has the beneficial effects that: without being bound to any existing theory, the mechanism of action of the present invention is presumed to be as follows: n-acetylneuraminic acid contains hydrophilic carboxyl, glyceryl and other groups, and is helpful for keeping the wettability of the nasal cavity; n-acetylneuraminic acid is used as a receptor of a pathogen, can be used as a pseudo receptor after being added into a nasal cavity, prevents the pathogen from being combined with a host cell, can combine chlorogenic acid with neuraminidase, inhibits the activity of neuraminidase, and prevents sialic acid at the tail end of the receptor from being hydrolyzed, so that the pathogen is prevented from being combined with the host cell, and the chlorogenic acid has antiviral and antibacterial functions; the betaine has moisturizing effect, and the quaternary ammonium salt structure ensures that the betaine has certain antiviral effect; the menthol has special fragrance, can stimulate nostrils, enables the nasal cavity to be more unobstructed and simultaneously kills partial pathogens.

Detailed Description

In order to make the technical solutions of the present invention better understood by those skilled in the art, the present invention will be further described in detail with reference to the following preferred embodiments;

the invention provides a nasal wash, which comprises sodium chloride, N-acetylneuraminic acid, chlorogenic acid, betaine and menthol, wherein the nasal wash is clear and transparent liquid medicine without sediment; the nasal wash is filled in the spray bottle and is matched with the spray bottle for use; the pH value of the nasal irrigation agent is between 2.5 and 5.5; the nasal wash is used for inhibiting or treating upper respiratory tract diseases, and inhibiting or treating upper respiratory tract virus infection, wherein the respiratory tract diseases comprise symptoms of nose dryness, itching and/or common cold and/or rhinovirus infection.

According to the technical scheme, the compound preferably comprises 1-15mg/mL of sodium chloride, 0.5-10mg/mL of N-acetylneuraminic acid, 0.5-5mg/mL of chlorogenic acid, 0.5-5mg/mL of betaine, 0.05-0.5mg/mL of menthol and the balance of purified water, and the following description is combined with specific examples.

Example 1

Weighing 1L of distilled water, adding 10g of sodium chloride, 1g of N-acetylneuraminic acid, 1g of chlorogenic acid, 1g of betaine and 0.1g of menthol, and fully stirring until the solution is clear and transparent; placing the mixed liquid at 80 deg.C for 1h for sterilization, and placing a 20ml PET spray bottle with direct-injection type nozzle under an ultraviolet lamp for irradiation for 2.5 h; after the sterilization is finished, the liquid is cooled, and the solution is filled into a spray bottle in an aseptic environment.

Example 2

Putting the filled nasal spray of the embodiment 1 into a constant-temperature drying oven at 40 ℃ for heat preservation for 24 hours, taking out the nasal spray after the heat preservation is finished, and recovering to the normal temperature; and observing whether the appearance, the character, the pH value and the like are changed.

The results show that the spray is stable under the above conditions.

Example 3

Putting the filled nasal spray of the embodiment 1 into a constant-temperature refrigerator at-4 ℃ for heat preservation for 24 hours, taking out the nasal spray after the heat preservation is finished, and recovering to the normal temperature; and observing whether the appearance, the character, the pH value and the like are changed.

	Before heat preservation at-4 DEG C	After heat preservation at-4 DEG C
			Colour(s)	Colorless and transparent	Colorless and transparent
Smell(s)	Without change	Without change
			Insoluble substance	Is free of	Is free of
pH	2.80	2.80

The results show that the spray is stable under the above conditions.

Example 4 comparative test

(1) Selecting 120 people with the average age of 40 +/-8;

(2) randomly dividing the subjects into a test group and a control group, wherein the control group comprises 60 persons, and the test group comprises 60 persons;

(3) the nasal wash of the invention described in example 1 was used in the test group, and 1% normal saline was used in the control group, and the specific amounts were as follows: spraying 2 times per day, and spraying 2 times to nasal cavity at each side for 30 days;

(4) the subjects evaluated the effect after 30 days, focusing mainly on the following: whether the nose patency is improved; whether nasal dryness is alleviated; whether or not upper respiratory infection occurs.

(5) After the test was completed, 54 cases were completed in the control group, and 52 cases were completed in the test group.

The test results are as follows:

the results show that the index test group in each aspect is superior to the control group, and the invention has the functions of moistening the nasal cavity, relieving the uncomfortable feeling of the nasal cavity, resisting the invasion of viruses, pathogenic bacteria and the like and avoiding the initiation of upper respiratory tract infection.

Example 5

The number of the three small-sized companies is 108 in 2019 from 11 months 1 to 12 months 30, and the average age is 36 +/-12; dividing the subjects into a test group and a control group by random double-blindness, wherein 54 cases of the control group and 54 cases of the test group are included; the nasal wash described in example 1 was used in the test group, and 1% normal saline was used in the control group, specifically in the following amounts: spraying 2 times per day, each nasal cavity for 2 times, and 60 days; the subjects evaluated the effect after 60 days, with the following main concerns: whether the upper respiratory tract infection occurs or not and the number of days after the upper respiratory tract infection is false.

After the test, the control group completed 50 cases, and the test group completed 49 cases.

The test results are as follows:

the results show that the index test group in all aspects is superior to the control group, and the experimental group data show that the number of days for illness is obviously better than the date of the same period in the last year; the nasal wash has the functions of moistening nasal cavity, relieving nasal discomfort, resisting invasion of virus, pathogenic bacteria, etc., and preventing upper respiratory tract infection.

The nose washing agent has the beneficial effects that: without being bound to any existing theory, the mechanism of action of the present invention is presumed to be as follows: n-acetylneuraminic acid contains hydrophilic carboxyl, glyceryl and other groups, and is helpful for keeping the wettability of the nasal cavity; n-acetylneuraminic acid is used as a receptor of a pathogen, and can be used as a pseudo receptor after being added into the nasal cavity, so that the pathogen is prevented from being combined with host cells; chlorogenic acid can be combined with neuraminidase to inhibit neuraminidase activity and prevent sialic acid at the tail end of a receptor from being hydrolyzed, so that pathogens are prevented from being combined with host cells, and the chlorogenic acid has antiviral and antibacterial functions; the betaine has moisturizing effect, and the quaternary ammonium salt structure ensures that the betaine has certain antiviral effect; the menthol has special fragrance, can stimulate nostrils, enables the nasal cavity to be more unobstructed and simultaneously kills partial pathogens.

The foregoing is only a preferred embodiment of the present invention, and it should be noted that, for those skilled in the art, various modifications and decorations can be made without departing from the principle of the present invention, and these modifications and decorations should also be regarded as the protection scope of the present invention.

Claims

1. A nasal wash is characterized by comprising sodium chloride, N-acetylneuraminic acid, chlorogenic acid, betaine and menthol.

2. The nasal wash according to claim 1, comprising sodium chloride 1-15mg/mL, N-acetylneuraminic acid 0.5-10mg/mL, chlorogenic acid 0.5-5mg/mL, betaine 0.5-5mg/mL, menthol 0.05-0.5mg/mL and the balance purified water.

3. A nasal wash according to claim 2, characterized by comprising 7-12mg/mL of sodium chloride, 0.5-5mg/mL of N-acetylneuraminic acid, 0.5-2mg/mL of chlorogenic acid, 0.5-2mg/mL of betaine, 0.05-0.2mg/mL of menthol and the balance of purified water.

4. A nasal wash according to claim 3, comprising 10mg/mL of sodium chloride, 1mg/mL of N-acetylneuraminic acid, 1mg/mL of chlorogenic acid, 1mg/mL of betaine, 0.1mg/mL of menthol and the balance of purified water.

5. A nasal rinse according to any one of claims 1 to 4, characterised in that the pH of the rinse is between 2.5 and 5.5.

6. A nasal wash according to any one of claims 1 to 4, wherein the nasal wash is for use in the inhibition or treatment of an upper respiratory disease, or an upper respiratory viral infection.

7. A nasal rinse according to claim 6, characterised in that respiratory complaints include symptoms of dry nose, itching and/or common cold and/or rhinovirus infection.