CN111602649B - Intervertebral disc organ cryopreservation box - Google Patents
Intervertebral disc organ cryopreservation box Download PDFInfo
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- CN111602649B CN111602649B CN202010383560.5A CN202010383560A CN111602649B CN 111602649 B CN111602649 B CN 111602649B CN 202010383560 A CN202010383560 A CN 202010383560A CN 111602649 B CN111602649 B CN 111602649B
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- box body
- fixed
- placing groove
- intervertebral disc
- fixed pipe
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- 210000000056 organ Anatomy 0.000 title claims abstract description 14
- 238000005138 cryopreservation Methods 0.000 title claims abstract description 10
- 239000011550 stock solution Substances 0.000 claims abstract description 5
- 239000000758 substrate Substances 0.000 claims description 15
- 238000007710 freezing Methods 0.000 abstract description 3
- 230000008014 freezing Effects 0.000 abstract description 3
- 238000004321 preservation Methods 0.000 abstract description 2
- 230000000903 blocking effect Effects 0.000 description 13
- 238000000034 method Methods 0.000 description 4
- 230000002265 prevention Effects 0.000 description 3
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
- 208000008035 Back Pain Diseases 0.000 description 2
- 108091003079 Bovine Serum Albumin Proteins 0.000 description 2
- 206010061246 Intervertebral disc degeneration Diseases 0.000 description 2
- 239000008280 blood Substances 0.000 description 2
- 210000004369 blood Anatomy 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 239000012091 fetal bovine serum Substances 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 description 1
- 239000006144 Dulbecco’s modified Eagle's medium Substances 0.000 description 1
- 208000008930 Low Back Pain Diseases 0.000 description 1
- 208000023178 Musculoskeletal disease Diseases 0.000 description 1
- 230000000735 allogeneic effect Effects 0.000 description 1
- 230000001754 anti-pyretic effect Effects 0.000 description 1
- 239000002221 antipyretic Substances 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 230000004927 fusion Effects 0.000 description 1
- 239000002609 medium Substances 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- 230000000149 penetrating effect Effects 0.000 description 1
- 238000002054 transplantation Methods 0.000 description 1
- 238000011282 treatment Methods 0.000 description 1
- 230000002747 voluntary effect Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N1/00—Preservation of bodies of humans or animals, or parts thereof
- A01N1/02—Preservation of living parts
- A01N1/0236—Mechanical aspects
- A01N1/0263—Non-refrigerated containers specially adapted for transporting or storing living parts whilst preserving, e.g. cool boxes, blood bags or "straws" for cryopreservation
- A01N1/0268—Carriers for immersion in cryogenic fluid, both for slow-freezing and vitrification, e.g. open or closed "straws" for embryos, oocytes or semen
-
- G—PHYSICS
- G09—EDUCATION; CRYPTOGRAPHY; DISPLAY; ADVERTISING; SEALS
- G09F—DISPLAYING; ADVERTISING; SIGNS; LABELS OR NAME-PLATES; SEALS
- G09F3/00—Labels, tag tickets, or similar identification or indication means; Seals; Postage or like stamps
- G09F3/02—Forms or constructions
- G09F3/0297—Forms or constructions including a machine-readable marking, e.g. a bar code
Landscapes
- Engineering & Computer Science (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Mechanical Engineering (AREA)
- Theoretical Computer Science (AREA)
- Hematology (AREA)
- Physics & Mathematics (AREA)
- General Physics & Mathematics (AREA)
- Dentistry (AREA)
- General Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Environmental Sciences (AREA)
- Prostheses (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
The invention relates to the field of medical equipment and discloses a freezing preservation box for intervertebral disc organs; comprising the following steps: the disc comprises a chassis, a box body for accommodating the intervertebral disc and a cover body; the upper end surface of the chassis is provided with a placing groove for accommodating the box body; the upper end of the box body is formed into an opening; the cover body covers the opening of the box body; the box body is internally filled with frozen stock solution; the volume of the box body is 2 to 4 times of the volume of the intervertebral disc. Compared with the prior art, the invention provides a container special for placing the intervertebral disc through the setting, and achieves the aim of facilitating the cryopreservation of the intervertebral disc.
Description
Technical Field
The invention relates to the field of medical equipment, in particular to a cryopreservation box for intervertebral disc organs.
Background
Organ donation refers to the voluntary presentation of a natural person before birth, after death, by his executives donating parts of the remains to medical science. Or the actions of donating all or part of remains to medical science by their immediate relatives after death of natural persons not showing a donation will before birth. Organs obtained from organ donation, such as intervertebral discs and the like, are typically preserved by cryogenic freezing.
Back pain is one of the most common musculoskeletal diseases. Although many potential factors may lead to low back pain, one known determinant is disc degeneration. The most effective treatments for severe disc degeneration are: spinal fusion and artificial disc replacement. Fresh cryopreserved disc grafts have been demonstrated as an effective method of treating rhesus and human antipyretic disc disease.
In the prior art, no container specially used for placing the intervertebral disc exists, so that a freezing preservation box for the intervertebral disc organ is to be proposed.
Disclosure of Invention
The invention aims to overcome the defects of the prior art and provide a cryopreservation box for intervertebral disc organs.
The technical scheme adopted for solving the problems in the prior art is as follows:
a disc organ cryopreservation cassette comprising: the disc comprises a chassis, a box body for accommodating the intervertebral disc and a cover body; the upper end face of the chassis is provided with a placing groove for accommodating the box body; the upper end of the box body is formed into an opening; the cover body covers the opening of the box body; the box body is internally filled with frozen stock solution; the volume of the box body is 2 to 4 times of the volume of the intervertebral disc.
The following further describes the above technical scheme:
preferably, the transparent sheet and the substrate are also included; the transparent sheet is fixed on the upper end face of the cover body and forms a containing cavity with the cover body; the substrate is arranged in the accommodating cavity; an opening for the substrate to extend into or withdraw from the accommodating cavity is formed between the transparent sheet and the cover body; the upper end face of the substrate is provided with a two-dimensional code, and the two-dimensional code is associated with the basic information of the donators of the intervertebral disc and the size of the intervertebral disc accommodated in the box body.
Preferably, the device further comprises an anti-falling mechanism; the anti-falling mechanism is fixed on the chassis and used for preventing the box body from falling out of the placing groove after being placed in the placing groove.
Preferably, the anti-drop mechanism includes: the device comprises a fixed pipe, a circular ring sleeve, a connecting rod, a transparent baffle and a limiting component; the fixed pipe is arranged along the up-down direction, and the lower end of the fixed pipe is fixed on the upper end surface of the chassis and is coaxially arranged with the chassis; the circular ring sleeve is sleeved on the outer wall of the fixed pipe in a sliding manner along the up-down direction; the connecting rod is horizontally arranged, and the end part of the connecting rod is fixed on the outer wall of the circular sleeve; the transparent baffle is horizontally arranged and fixed on one side of the connecting rod, which is far away from the circular sleeve; the limiting component is fixed on the fixed pipe and is used for limiting the rotation of the circular sleeve after the transparent baffle plate is opposite to the placing groove;
when the box body is placed in the placing groove, the circular ring sleeve is rotated until the transparent baffle is rotated to be right against the placing groove, and the limiting component limits the rotation of the circular ring sleeve, so that the box body is prevented from falling out of the placing groove after being placed in the placing groove.
Preferably, the restriction assembly comprises: the sliding plate comprises a through groove, a top plate, a sliding plate, a first elastic piece, a limiting rod, a first bayonet and a second bayonet;
the two through grooves are oppositely arranged on two sides of the inner wall of the fixed pipe, correspondingly penetrate through the outer wall of the fixed pipe and are arranged along the up-down direction; the top plate is fixed at the upper end of the fixed pipe; the sliding plate is connected in the fixed pipe in a sliding way along the up-down direction; the upper end of the first elastic piece is fixed at the lower end of the top plate, and the lower end of the first elastic piece is fixed at the upper end of the sliding plate; the two limiting rods are correspondingly connected in the two through grooves in a sliding way along the up-down direction, the first ends of the limiting rods are oppositely arranged at the two sides of the outer wall of the sliding plate, and the second ends of the limiting rods correspondingly penetrate through the two through grooves; the two first bayonets are oppositely arranged on two sides of the upper end surface of the circular ring sleeve and correspondingly matched with the two limiting rods in a clamping way; the two second bayonets are oppositely arranged on the other two sides of the upper end surface of the circular ring sleeve and correspondingly matched with the two limiting rods in a clamping way;
when the two limiting rods are correspondingly clamped at the two first bayonets, the transparent baffle plate is opposite to the placing groove; when the two limiting rods are correspondingly clamped at the two second bayonets, the transparent baffle is positioned beside the placing groove.
Preferably, the anti-drop mechanism includes: the sliding groove, the sector sliding groove, the sliding block, the second elastic piece and the blocking rod;
the sliding groove is arranged on the inner side wall of the placing groove along the up-down direction, and the upper end of the sliding groove is communicated with the upper end face of the chassis; the fan-shaped sliding groove is formed in the inner side wall of the placing groove and is communicated with the side wall of the sliding groove; the sliding block is fixed on the outer wall of the box body, can slide in the sliding groove along the up-down direction, and can circumferentially rotate and slide to the sector sliding groove; the second elastic piece is fixed on the bottom wall of the chute; the blocking rod is connected in the sliding groove in a sliding mode along the up-down direction, the lower end of the blocking rod is fixed on the second elastic piece, and the upper end of the blocking rod is provided with an inclined surface which is opposite to the sector sliding groove.
Preferably, the anti-drop mechanism includes: the clamping block, the clamping groove and the driving assembly; the clamping block is detachably fixed at the lower end of the box body; the clamping groove is formed in the bottom wall of the placing groove; the driving assembly is fixed in the clamping groove, and the driving assembly drives the clamping block to be locked in the clamping groove or unlocked from the clamping groove.
Preferably, the driving assembly includes: the clamping block and the third elastic piece; the clamping block is hooked and matched with the clamping block and is connected to the bottom wall of the clamping groove in a sliding manner along the left-right direction; one end of the third elastic piece is fixed at the left end of the clamping block, and the other end of the third elastic piece is fixed at the left inner wall of the clamping groove; the clamping block is provided with a first inclined plane towards one side of the third elastic piece, and a second inclined plane parallel and opposite to the first inclined plane is arranged on the clamping block.
Preferably, the driving assembly further comprises: an elastic rope and a pull ring; a rope passing hole penetrating through the side wall of the chassis is formed in the left inner wall of the clamping groove leftwards; one end of the elastic rope is fixed on the left side of the clamping block, and the other end of the elastic rope penetrates through the rope passing hole to be connected with the pull ring.
Preferably, the two sides of the upper end surface of the chassis are oppositely provided with first lifting loops; second lifting tabs are oppositely arranged on two sides of the upper end face of the box body; the lower end of the cover body is fixedly connected with a protruding block which is in threaded connection with the upper end of the inner wall of the box body.
The beneficial effects of the invention are as follows:
the method comprises the following steps: when the intervertebral disc obtained by organ donation is frozen and preserved, firstly, the cover body is opened, frozen storage liquid is added into the box body, and then the intervertebral disc is placed into the box body; secondly, placing the box body into a placing groove of the chassis; finally, the chassis is placed into a liquid nitrogen tank, so that the intervertebral disc can be refrigerated and preserved. Compared with the prior art, the invention provides a container special for placing the intervertebral disc through the setting, and achieves the aim of facilitating the cryopreservation of the intervertebral disc;
and two,: through setting up of transparent piece, substrate and two-dimensional code for through scanning two-position code, can learn the basic information of the donor of intervertebral disc that holds in the box body, such as blood group and the intervertebral disc size etc. of donor, so that can take the intervertebral disc from the intervertebral disc storehouse accurately when carrying out allogeneic intervertebral disc transplantation, the rewarming reserve.
Drawings
FIG. 1 is a schematic structural view of an intervertebral disc;
FIG. 2 is a schematic view of a first view structure according to the first embodiment;
FIG. 3 is a schematic view of the structure of the case;
FIG. 4 is a schematic view of a second view structure according to the first embodiment;
FIG. 5 is an enlarged schematic view of the structure of FIG. 4A;
fig. 6 is a schematic structural view for showing the anti-falling mechanism in the second embodiment;
fig. 7 is a schematic view for showing the structure of the anti-drop mechanism in the third embodiment.
The achievement of the objects, functional features and advantages of the present invention will be further described with reference to the accompanying drawings, in conjunction with the embodiments.
10, a chassis; 101. a placement groove; 102. a first tab; 20. a case body; 30. a cover body; 301. A second tab; 302. a bump; 401. a transparent sheet; 402. a substrate; 501. a fixed tube; 502. a circular ring sleeve; 503. a connecting rod; 504. a transparent baffle; 505. a restriction assembly; 5051. a through groove; 5052. a top plate; 5053. a sliding plate; 5054. a first elastic member; 5055. a limit rod; 5056. a first bayonet; 5057. A second bayonet; 601. a chute; 602. a sector sliding groove; 603. a slide block; 604. a second elastic member; 605. a blocking lever; 6051. an inclined surface; 701. a clamping block; 702. a clamping groove; 7031. a clamping block; 7032. a third elastic member; 7033. an elastic rope; 7034. a pull ring; 801. a sliding groove; 802. a sliding block.
Detailed Description
The following detailed description of the present invention will be given with reference to the accompanying drawings and specific embodiments, so as to more clearly and intuitively understand the essence of the present invention.
Embodiment one:
as shown in FIG. 1, the length L of the disc is about 60mm, the width W of the disc is about 41mm, and the height of the disc is about 15 mm.
Referring to fig. 2 and 3, the present invention provides a cryopreservation cassette for an intervertebral disc organ, comprising: chassis 10, case 20, and cover 30. The upper end surface of the chassis 10 is provided with a placing groove 101, and the placing groove 101 is used for accommodating the box body 20; the upper end of the case 20 is formed as an opening; the cover 30 covers the opening of the box 20; the box 20 contains frozen stock solution. The frozen stock solution comprises: 10% DMSO (dimethyl sulfoxide), 80% DMEM (medium), and 10% FBS (fetal bovine serum).
In this embodiment, the volume of the cartridge 20 is set to 3 times the disc volume; in other embodiments, the volume of the cartridge 20 may also be 2, 2.5, 3.5, or 4 times the volume of the disc. Preferably, the 5 placing grooves 101 are circumferentially arranged around the axis of the chassis 10 and are uniformly arranged on the upper end surface of the chassis 10 at intervals, and the number of the box bodies 20 is consistent with that of the placing grooves 101; in other embodiments, the number of the placement slots 101 and the number of the boxes 20 may be 4.
As shown in fig. 3, in order to facilitate learning about information about the intervertebral disc contained in the case 20, the present invention is provided with: transparent sheet 401 and substrate 402.
The transparent sheet 401 is rectangular and is arranged in a transparent way, three sides of the transparent sheet 401 are fixed on the upper end face of the cover body 30, a containing cavity is formed between the transparent sheet 401 and the cover body 30, and the substrate 402 is arranged in the containing cavity; an opening for the substrate 402 to extend into or withdraw from the cavity is formed between the other edge of the transparent sheet 401 and the cover 30; the upper end surface of the substrate 402 is provided with a two-dimensional code, and the two-dimensional code is associated with basic information of a donor of the intervertebral disc accommodated in the box body 20 and the size of the intervertebral disc, wherein the basic information of the donor is mainly blood type of the donor and the like. By scanning the two-dimensional code on the substrate 402, the donor information of the disc and the disc size of the disc contained in the cartridge 20 can be known.
As shown in fig. 4 and 5, in order to prevent the cartridge 20 from falling out of the placement groove 101 after being placed in the placement groove 101, the present invention is provided with: an anti-falling mechanism. The anti-falling mechanism is fixed on the chassis 10 and is used for preventing the box body 20 from falling out of the placing groove 101 after being placed into the placing groove 101.
The anti-drop mechanism includes: a fixed tube 501, a circular sleeve 502, a connecting rod 503, a transparent baffle 504, and a restraint assembly 505.
The fixed pipe 501 is arranged along the up-down direction, the lower end of the fixed pipe 501 is fixed on the upper end surface of the chassis 10, and the fixed pipe 501 and the chassis 10 are coaxially arranged; the circular ring sleeve 502 is sleeved on the outer wall of the fixed pipe 501 in a sliding manner along the up-down direction, and the inner diameter of the circular ring sleeve 502 is equal to the outer diameter of the fixed pipe 501; the connecting rods 503 are horizontally arranged, five connecting rods 503 are uniformly arranged at intervals along the circumferential direction of the outer wall of the circular ring sleeve 502, and the end parts of the five connecting rods 503 are respectively fixed on the outer wall of the circular ring sleeve 502; the transparent baffles 504 are horizontally arranged, and the five transparent baffles 504 are respectively fixed on one side of the five connecting rods 503 far away from the circular sleeve 502; the vertical distance between the end of the placing groove 101 far from the fixed pipe 501 and the fixed pipe 501 is smaller than the vertical distance between the end of the transparent baffle 504 far from the fixed pipe 501 and the fixed pipe 501; the vertical distance between the end of the placing groove 101 close to the fixed pipe 501 and the fixed pipe 501 is larger than the vertical distance between the end of the transparent baffle 504 close to the fixed pipe 501 and the fixed pipe 501; the limiting assembly 505 is fixed on the fixed pipe 501, and the limiting assembly 505 is used for limiting the rotation of the annular sleeve 502 after the five transparent baffles 504 are respectively opposite to the five placing grooves 101.
After the box body 20 is placed in the placing groove 101, the annular sleeve 502 is rotated until the five transparent baffles 504 are correspondingly rotated to be opposite to the five placing grooves 101, and the limiting assembly limits the rotation of the annular sleeve 502, so that the purpose of preventing the box body 20 from falling out of the placing groove 101 after being placed in the placing groove 101 is achieved.
As shown in connection with fig. 4 and 5, the restriction assembly 505 includes: the channel 5051, top plate 5052, sliding plate 5053, first spring 5054, stop bar 5055, first bayonet 5056, and second bayonet 5057.
The two-way grooves 5051 are formed on two opposite sides of the inner wall of the fixed pipe 501, and the two-way grooves 5051 correspondingly penetrate through the outer wall of the fixed pipe 501 and are arranged along the up-down direction; the top plate 5052 is fixed at the upper end of the fixed pipe 501; the sliding plate 5053 is slidably coupled in the up-down direction within the fixed pipe 501; the upper end of the first elastic member 5054 is fixed at the lower end of the top plate 5052, and the lower end of the first elastic member 5054 is fixed at the upper end of the sliding plate 5053; the two limiting rods 5055 are correspondingly connected in the two-way slot 5051 in a sliding manner along the up-down direction, the first ends of the two limiting rods 5055 are relatively fixed at two sides of the outer wall of the sliding plate 5053, and the second ends of the two limiting rods 5055 correspondingly penetrate through the two-way slot 5051; two first bayonets 5056 are oppositely arranged on two sides of the upper end surface of the circular sleeve 502 and correspondingly are in clamping fit with two limit rods 5055; two second bayonets 5057 are oppositely arranged on the other two sides of the upper end surface of the annular sleeve 502 and correspondingly are in clamping fit with the two limit rods 5055. When the two limiting rods 5055 are correspondingly clamped at the two first bayonets 5056, the five transparent baffles 504 are respectively opposite to the five placing grooves 101; when the two limiting rods 5055 are correspondingly clamped at the two second bayonets 5057, the five transparent baffles 504 are respectively located beside the five placing grooves 101. Preferably, the first resilient member 5054 is provided as a spring.
When the circular sleeve 502 is rotated, firstly, the two limit rods 5055 are slid upwards along the two-way groove 5051 until the lower ends of the two limit rods 5055 are spaced from the upper end of the circular sleeve 502, the sliding plate 5053 is driven to slide upwards along the inner wall of the fixed pipe 501, and the first elastic piece 5054 is compressed; secondly, the circular sleeve 502 is rotated until the five transparent baffles 504 correspondingly rotate to be opposite to the five placing grooves 101, the limiting rods 5055 are loosened, the sliding plate 5053 is driven to slide downwards along the inner wall of the fixed pipe 501 under the action of the resilience force of the first elastic piece 5054, the two limiting rods 5055 are driven to slide downwards along the two through grooves 5051 until the two limiting rods 5055 correspondingly are clamped at the two first bayonets 5056, and the rotation of the circular sleeve 502 can be limited.
When the circular sleeve 502 is rotated, firstly, the two limit rods 5055 are slid upwards along the two-way groove 5051 until the lower ends of the two limit rods 5055 are spaced from the upper end of the circular sleeve 502, the sliding plate 5053 is driven to slide upwards along the inner wall of the fixed pipe 501, and the first elastic piece 5054 is compressed; secondly, the circular sleeve 502 is rotated until the five transparent baffles 504 correspondingly rotate to the sides of the five placing grooves 101, the limiting rods 5055 are loosened, the sliding plate 5053 is driven to slide downwards along the inner wall of the fixed pipe 501 under the action of the resilience force of the first elastic piece 5054, the two limiting rods 5055 are driven to slide downwards along the two through grooves 5051 until the two limiting rods 5055 correspondingly are clamped at the two second bayonets 5057, and the rotation of the circular sleeve 502 can be limited.
Preferably, the two sides of the upper end surface of the chassis 10 are oppositely provided with first lifting tabs 102 so as to facilitate the movement of the chassis 10; second lifting tabs 301 are oppositely arranged on two sides of the upper end surface of the cover 30 so as to facilitate moving the box 20.
Embodiment two:
as shown in fig. 6, the difference from the first embodiment is that the drop prevention mechanism includes: the sliding groove 601, the fan-shaped sliding groove 602, the sliding block 603, the second elastic piece 604 and the blocking rod 605.
The chute 601 is arranged on the inner side wall of the placing groove 101 along the up-down direction, and the upper end of the chute 601 is communicated with the upper end face of the chassis 10; the sector sliding groove 602 is formed in the inner side wall of the placing groove 101, and the left end of the sector sliding groove 601 is communicated with the right side wall of the sliding groove 601; the sliding block 603 is fixed on the outer wall of the box body 20, the sliding block 603 can slide in the sliding groove 601 along the up-down direction, the sliding block 603 can circumferentially rotate and slide to the fan-shaped sliding groove 602, and the sliding block 603 can slide in the fan-shaped sliding groove 602 around the axis of the placing groove 101; the second elastic piece 604 is fixed on the bottom wall of the chute 601; the blocking rod 605 is slidably connected in the chute 601 along the up-down direction, the lower end of the blocking rod 605 is fixed on the second elastic piece 604, and the upper end of the blocking rod 605 is provided with an inclined surface 6051 which is opposite to the sector sliding groove 602.
Preferably, the upper end of the inclined surface 6051 is flush with the upper end of the fan-shaped sliding groove 602, and the lower end of the inclined surface 6051 is flush with the lower end of the fan-shaped sliding groove 602; the second elastic member 604 is provided as a spring.
When the box body 20 is placed in the placing groove 101, firstly, the sliding block 603 is aligned to the sliding groove 601, then the box body 20 is placed in the placing groove 101, the sliding block 603 is driven to slide downwards along the sliding groove 601, the sliding block 603 pushes the blocking rod 605 to slide downwards, and the blocking rod 605 compresses the second elastic piece 604; after the box body 20 is placed in the placing groove 101, the sliding block 603 is opposite to the sector sliding groove 602; then, the box 20 is rotated to drive the sliding block 603 to slide into the fan-shaped sliding groove 602 from the sliding groove 601, and at this time, under the action of the resilience of the second elastic member 604, the blocking rod 605 is driven to slide upwards until the inclined surface 6051 is opposite to the fan-shaped sliding groove 602.
When the box 20 is taken out from the placement groove 101, firstly, the box 20 is rotated to drive the sliding block 603 to rotate from the sliding groove 601 in the fan-shaped sliding groove 602, and in the process, the lower end of the left side of the sliding block 603 slides along the inclined surface 6051, so that the blocking rod 605 is driven to slide downwards and compress the second elastic piece 604 until the sliding block 603 slides into the sliding groove 601; next, the box 20 is taken out upwards, and the sliding block 603 is driven to slide upwards along the sliding groove 601 and slide out from the upper end of the sliding groove 601. By the above setting, the purpose of preventing the box body 20 from falling out of the placement groove 101 after being placed in the placement groove 101 is achieved.
In this embodiment, the same effects as those of the drop prevention mechanism in the first embodiment are achieved by the above-described setting.
Embodiment III:
as shown in fig. 7, the difference from the first embodiment is that the drop prevention mechanism includes: the fixture block 701, the clamping groove 702 and the driving assembly.
The clamping block 701 is in a hook shape, and the clamping block 701 is detachably fixed at the lower end of the box body 20; the clamping groove 702 is formed in the bottom wall of the placing groove 101; the driving assembly is fixed in the clamping groove 702, and the driving assembly drives the clamping block 701 to be locked in the clamping groove 702 or unlocked from the clamping groove 702.
Preferably, the upper end of the clamping block 701 is in threaded connection with the lower end of the box body 20, and after the clamping block 701 is unscrewed from the box body 20, the box body 20 can be stably placed on an operating table.
The drive assembly includes: the locking block 7031, the third elastic member 7032, the elastic cord 7033, and the pull ring 7034.
The clamping block 7031 is in a barb shape, the clamping block 7031 is hooked and matched with the clamping block 701, and the clamping block 7031 is slidably connected to the bottom wall of the clamping groove 702 along the left-right direction; one end of the third elastic piece 7032 is fixed at the left end of the clamping block 7031, and the other end of the third elastic piece 7032 is fixed at the left inner wall of the clamping groove 702; a first inclined surface is arranged on one side of the clamping block 701 facing the third elastic piece 7032, and a second inclined surface parallel and opposite to the first inclined surface is arranged on the clamping block 7031; the left inner wall of the clamping groove 702 is provided with a rope passing hole which penetrates through to the side wall of the chassis 10 to the left; one end of the elastic rope 7033 is fixed on the left side of the clamping block 7031, and the other end of the elastic rope 7033 passes through the rope passing hole to be connected with the pull ring 7034.
Preferably, the third elastic member 7032 is provided as a spring; the bottom wall of the clamping groove 702 is provided with a sliding groove 801 along the left-right direction, and the lower end of the clamping block 7031 is fixed with a sliding block 802 which is connected in the sliding groove 801 in a sliding way along the left-right direction.
When the clamping block 701 is locked, the clamping block 701 is inserted into the clamping groove 702, the first inclined plane is abutted against the second inclined plane, the clamping block 701 extrudes the clamping block 7031, the first inclined plane slides along the second inclined plane, the clamping block 7031 is driven to slide leftwards and compress the third elastic element 7032 until the first inclined plane is positioned below the second inclined plane, and then the clamping block 7031 is driven to slide rightwards and be hooked with the clamping block 701 under the action of the self resilience force of the third elastic element 7032, so that the clamping block 701 can be locked.
When the clamping block 701 is unlocked, the pull ring 7034 is pulled leftwards, the clamping block 7031 is pulled to slide leftwards through the elastic rope 7033 until the clamping block 7031 is separated from the clamping block 701, and the clamping block 701 can be pulled out from the clamping groove 702, so that the unlocking of the clamping block 701 is convenient and easy.
Preferably, the lower end of the cover 30 is fixedly provided with a protrusion 302 screwed on the upper end of the inner wall of the case 20, so as to ensure tightness between the cover 30 and the case 20.
In this embodiment, the same effects as those of the first embodiment are achieved by the above-described setting.
The foregoing description is only of the preferred embodiments of the present invention and is not intended to limit the scope of the invention, and all equivalent structures or equivalent processes using the descriptions and drawings of the present invention or directly or indirectly applied to other related technical fields are included in the scope of the invention.
Claims (2)
1. A disc organ cryopreservation cassette comprising: the disc comprises a chassis, a box body for accommodating the intervertebral disc and a cover body; the upper end face of the chassis is provided with a placing groove for accommodating the box body; the upper end of the box body is formed into an opening; the cover body covers the opening of the box body; the box body is internally filled with frozen stock solution; the volume of the box body is 2 to 4 times of the volume of the intervertebral disc;
the transparent sheet and the substrate are also included; the transparent sheet is fixed on the upper end face of the cover body and forms a containing cavity with the cover body; the substrate is arranged in the accommodating cavity; an opening for the substrate to extend into or withdraw from the accommodating cavity is formed between the transparent sheet and the cover body; the upper end face of the substrate is provided with a two-dimensional code, and the two-dimensional code is associated with the basic information of a donor of the intervertebral disc and the size of the intervertebral disc accommodated in the box body;
the anti-falling mechanism is also included; the anti-falling mechanism is fixed on the chassis and is used for preventing the box body from falling out of the placing groove after being placed in the placing groove;
the anti-drop mechanism comprises: the device comprises a fixed pipe, a circular ring sleeve, a connecting rod, a transparent baffle and a limiting component;
the fixed pipe is arranged along the up-down direction, and the lower end of the fixed pipe is fixed on the upper end surface of the chassis and is coaxially arranged with the chassis; the circular ring sleeve is sleeved on the outer wall of the fixed pipe in a sliding manner along the up-down direction; the connecting rod is horizontally arranged, and the end part of the connecting rod is fixed on the outer wall of the circular sleeve; the transparent baffle is horizontally arranged and fixed on one side of the connecting rod, which is far away from the circular sleeve; the limiting component is fixed on the fixed pipe and is used for limiting the rotation of the circular sleeve after the transparent baffle plate is opposite to the placing groove;
when the box body is placed in the placing groove, the circular ring sleeve is rotated until the transparent baffle is rotated to be opposite to the placing groove, and the limiting component limits the rotation of the circular ring sleeve, so that the box body is prevented from falling out of the placing groove after being placed in the placing groove;
the limiting assembly includes: the sliding plate comprises a through groove, a top plate, a sliding plate, a first elastic piece, a limiting rod, a first bayonet and a second bayonet;
the two through grooves are oppositely arranged on two sides of the inner wall of the fixed pipe, correspondingly penetrate through the outer wall of the fixed pipe and are arranged along the up-down direction; the top plate is fixed at the upper end of the fixed pipe; the sliding plate is connected in the fixed pipe in a sliding way along the up-down direction; the upper end of the first elastic piece is fixed at the lower end of the top plate, and the lower end of the first elastic piece is fixed at the upper end of the sliding plate; the two limiting rods are correspondingly connected in the two through grooves in a sliding way along the up-down direction, the first ends of the limiting rods are oppositely arranged at the two sides of the outer wall of the sliding plate, and the second ends of the limiting rods correspondingly penetrate through the two through grooves; the two first bayonets are oppositely arranged on two sides of the upper end surface of the circular ring sleeve and correspondingly matched with the two limiting rods in a clamping way; the two second bayonets are oppositely arranged on the other two sides of the upper end surface of the circular ring sleeve and correspondingly matched with the two limiting rods in a clamping way;
when the two limiting rods are correspondingly clamped at the two first bayonets, the transparent baffle plate is opposite to the placing groove; when the two limiting rods are correspondingly clamped at the two second bayonets, the transparent baffle is positioned beside the placing groove.
2. The intervertebral disc organ cryopreservation cassette of claim 1, wherein first tabs are oppositely disposed on both sides of the upper end surface of the chassis; second lifting tabs are oppositely arranged on two sides of the upper end face of the box body; the lower end of the cover body is fixedly connected with a protruding block which is in threaded connection with the upper end of the inner wall of the box body.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202010383560.5A CN111602649B (en) | 2020-05-08 | 2020-05-08 | Intervertebral disc organ cryopreservation box |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202010383560.5A CN111602649B (en) | 2020-05-08 | 2020-05-08 | Intervertebral disc organ cryopreservation box |
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| Publication Number | Publication Date |
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| CN111602649A CN111602649A (en) | 2020-09-01 |
| CN111602649B true CN111602649B (en) | 2024-03-29 |
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| CN202010383560.5A Active CN111602649B (en) | 2020-05-08 | 2020-05-08 | Intervertebral disc organ cryopreservation box |
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Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN206172102U (en) * | 2016-09-29 | 2017-05-17 | 广州赛莱拉干细胞科技股份有限公司 | Novel freezing tube box |
| CN108045765A (en) * | 2017-12-19 | 2018-05-18 | 上海原能细胞生物低温设备有限公司 | A kind of rotating disc type low temperature accesses integrated device |
| CN208031292U (en) * | 2017-08-31 | 2018-11-02 | 新昌县羽林街道金敏轴承厂 | A kind of scissors apparatus for placing of operation |
| CN208217314U (en) * | 2018-04-28 | 2018-12-11 | 上海原能细胞生物低温设备有限公司 | A kind of freezing storing box |
| CN212589915U (en) * | 2020-05-08 | 2021-02-26 | 北京大学深圳医院 | Intervertebral disc organ cryopreservation box |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8419739B2 (en) * | 2009-08-24 | 2013-04-16 | Amir A. Jamali | Method and apparatus for allograft disc transplantation |
-
2020
- 2020-05-08 CN CN202010383560.5A patent/CN111602649B/en active Active
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN206172102U (en) * | 2016-09-29 | 2017-05-17 | 广州赛莱拉干细胞科技股份有限公司 | Novel freezing tube box |
| CN208031292U (en) * | 2017-08-31 | 2018-11-02 | 新昌县羽林街道金敏轴承厂 | A kind of scissors apparatus for placing of operation |
| CN108045765A (en) * | 2017-12-19 | 2018-05-18 | 上海原能细胞生物低温设备有限公司 | A kind of rotating disc type low temperature accesses integrated device |
| CN208217314U (en) * | 2018-04-28 | 2018-12-11 | 上海原能细胞生物低温设备有限公司 | A kind of freezing storing box |
| CN212589915U (en) * | 2020-05-08 | 2021-02-26 | 北京大学深圳医院 | Intervertebral disc organ cryopreservation box |
Also Published As
| Publication number | Publication date |
|---|---|
| CN111602649A (en) | 2020-09-01 |
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