CN111569070A - Application of black traditional Chinese medicine in preparation of photothermal therapy preparation - Google Patents
Application of black traditional Chinese medicine in preparation of photothermal therapy preparation Download PDFInfo
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- CN111569070A CN111569070A CN202010440883.3A CN202010440883A CN111569070A CN 111569070 A CN111569070 A CN 111569070A CN 202010440883 A CN202010440883 A CN 202010440883A CN 111569070 A CN111569070 A CN 111569070A
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- 239000003381 stabilizer Substances 0.000 claims description 2
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
- A61K41/0052—Thermotherapy; Hyperthermia; Magnetic induction; Induction heating therapy
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/42—Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
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- Chemical Kinetics & Catalysis (AREA)
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- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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Abstract
The invention discloses application of black traditional Chinese medicine in preparing a photothermal therapy preparation. The research shows that: the black traditional Chinese medicine has excellent photo-thermal conversion effect, and can be further applied to preparing photo-thermal treatment preparations, so that the invention further develops the new application of the black traditional Chinese medicine and improves the economic value of the black traditional Chinese medicine. In addition, when the black traditional Chinese medicine is applied to a photothermal therapy preparation and combined with fibroin to be used as a wound dressing, due to the photothermal conversion effect, the conformation of the fibroin can be changed under the irradiation of near infrared light during use, the migration and proliferation of new epithelial cells at a wound part can be promoted, meanwhile, the black traditional Chinese medicine can also permeate into wound tissues to play the pharmacological properties of the fibroin, and high temperature generated by the photothermal effect can effectively sterilize the wound in time to form a sterile environment at the wound part, so that the wound healing speed is further improved, and the fibroin has excellent biodegradability and biocompatibility.
Description
Technical Field
The invention relates to a new application of a black traditional Chinese medicine, in particular to an application of the black traditional Chinese medicine in preparing a photothermal therapy preparation.
Background
The skin is one of the most important organs of the human body, has the functions of immune barrier protection, secretion and excretion and thermoregulation, and is the first defense line against the invasion of pathogenic microorganisms. In the self-wound repair mechanism of human body, the repair capability of the human body's own tissues is mainly relied on, but the self-repair speed is slow, the normal life of people is affected, and even more, serious inflammation infection is caused, and even the life is threatened. The wound healing mainly comprises the complex combined processes of regeneration of various cells and tissues, granulation tissue proliferation and scar tissue formation, and the various processes show synergistic action. The basic process of wound healing consists of an acute inflammatory phase, a cell proliferative phase, a scarring phase, and regeneration of epidermis and other tissues.
Most of commercially available wound dressings are formed by mixing a main material and a water-absorbing substance, the main material is a gelatin-based material and provides an adhesive point, and the water-absorbing substance is a water-absorbing high-molecular polymer, so that the dressings can enable a wound to be in a better closed environment and a sterile environment, and promote the migration of new epithelial cells, thereby promoting the healing of the wound. But the biocompatibility is poor, the wound healing speed is slow, the effect is not obvious, and further development of the wound healing agent is limited.
Disclosure of Invention
The invention aims to provide application of black traditional Chinese medicine in preparing a photothermal therapy preparation.
The technical scheme adopted by the invention is as follows:
application of black traditional Chinese medicine in preparing photothermal therapy preparation.
The black traditional Chinese medicine is applied to the preparation of skin photothermal treatment preparations.
The black traditional Chinese medicine is applied to preparing a skin wound photothermal treatment preparation.
The black Chinese medicine is at least one selected from Polygoni Multiflori radix, radix rehmanniae Preparata, Ganoderma extract, Cistanchis herba, caulis Sargentodoxae, radix Ginseng Indici, and fructus Nicandrae.
The black Chinese medicine is at least one of radix rehmanniae Preparata, Ganoderma extract and Cistanchis herba.
The photothermal therapy preparation further comprises a pharmaceutically acceptable carrier, diluent, excipient or stabilizer.
The photothermal therapy preparation comprises black traditional Chinese medicine and fibroin.
The mass ratio of the black traditional Chinese medicine to the fibroin is 1: 5-1: 50.
the mass ratio of the black traditional Chinese medicine to the fibroin is 1: 10-1: 30.
the invention has the beneficial effects that:
1. proved by research, black Chinese medicaments such as: the polygonum multiflorum, the rehmannia and the like have excellent photo-thermal conversion effect and can be further applied to preparing photo-thermal treatment preparations, so that the invention further develops the new application of the black traditional Chinese medicine and improves the economic value of the black traditional Chinese medicine.
2. When the black traditional Chinese medicine is applied to a photothermal therapy preparation and combined with fibroin to be used as a wound dressing, due to the photothermal conversion effect, the conformation of the fibroin can be changed under the irradiation of near infrared light during use (the fibroin is converted from alpha-helix to beta-folding), the migration and proliferation of new epithelial cells at a wound part can be promoted, meanwhile, the black traditional Chinese medicine can also permeate into wound tissues to play the pharmacological performance, and the high temperature generated by the photothermal effect can effectively sterilize the wound in time to enable the wound part to form an aseptic environment, so that the wound healing speed is further improved, and furthermore, the fibroin has excellent biodegradability and biocompatibility.
3. The preparation method of the photothermal therapy preparation is very simple, the cost is low, and the preparation is very convenient and quick to use.
Drawings
FIG. 1 is a graph of photothermal curves of radix rehmanniae Preparata solutions of varying solids content;
FIG. 2 is a graph of photothermal curves of solutions of Ganoderma lucidum extract at different solids contents;
FIG. 3 is a graph of photothermal curves of cistanche solutions of different solids contents;
FIG. 4 is a graph of photothermal curves of fibroin solutions;
FIG. 5 is a graph of fibroin after vacuum drying;
FIG. 6 is a diagram of a prepared rehmannia root solution with a solid content of 100 mg/mL;
FIG. 7 is a diagram of the wound healing preparation prepared;
FIG. 8: a is a thermal imaging graph in a test group mouse; b is a thermal imaging picture in vivo of a control group mouse;
FIG. 9 is a graph comparing wounds of mice treated with the control group and the test group for 1 day after successful wound modeling;
FIG. 10: a is a staining pattern of HE of the wound of the mouse after the control group is treated; b is a staining graph of HE of the wound of the mouse after the treatment of the test group;
FIG. 11 is a graph showing a comparison of wounds in mice treated with the control group and the test group for 9 days after successful wound modeling.
Detailed Description
The present invention will be described in further detail with reference to examples. It will also be understood that the following examples are included merely for purposes of further illustrating the invention and are not to be construed as limiting the scope of the invention, as the invention extends to insubstantial modifications and adaptations of the invention following in the light of the principles set forth herein. The specific process parameters and the like of the following examples are also only one example of suitable ranges, and the skilled person can make a selection within the suitable ranges through the description herein, and are not limited to the specific data of the following examples.
1. The photo-thermal effect research of black traditional Chinese medicines with different solid contents, namely prepared rehmannia root, lucid ganoderma extract and desertliving cistanche, and fibroin:
weighing 1g radix rehmanniae Preparata, Ganoderma extract and Cistanchis herba respectively, grinding with water to obtain radix rehmanniae Preparata, Ganoderma extract and Cistanchis herba mother liquor with solid content of 100mg/mL, diluting to obtain radix rehmanniae Preparata, Ganoderma extract and Cistanchis herba solution with solid content of 1mg/mL, 20mg/mL, 40mg/mL, 80mg/mL and 100mg/mL respectively, and placing the above solution and 50mg/mL fibroin solution under a laser (Shanghai Xilong opto-electronic technology Co., Ltd.) with wavelength of 808nm at 1.0W/cm2Power exposure for 10min, temperature changes over time were recorded with a thermal imager, water as control, and the results are shown in figures 1, 2, 3 and 4:
as can be seen from fig. 1, 2, 3 and 4: under the same illumination condition, compared with the control group, the solution containing the prepared rehmannia root, the lucid ganoderma extract and the cistanche raises the temperature, and the concentration of the solution rises along with the increase of the contents of the prepared rehmannia root, the lucid ganoderma extract and the cistanche, so that the prepared rehmannia root, the lucid ganoderma extract and the cistanche show concentration dependence, and the prepared rehmannia root, the lucid ganoderma extract and the cistanche have excellent photothermal conversion effect, while the fibroin solution does not have photothermal conversion effect.
2. Application of prepared rehmannia root to photothermal therapy preparation and as wound healing preparation:
preparation of wound healing preparation:
1) preparation of fibroin solution: dissolving washed and cut pupa Bombycis in 5% Na2CO3Adding into 500mL water solution of 2.5% mosaic soap, boiling in electromagnetic oven for 30min, washing with deionized water for three times, vacuum drying overnight to obtain silk fiber;
weighing 2g of silk fiber, dissolving the silk fiber in 10mL of 9.4M lithium bromide solution, standing at 60 ℃ for 4h, then carrying out magnetic stirring dialysis on the lithium bromide solution in which the silk fiber is dissolved, and removing impurities and lithium bromide to obtain silk fiber solution;
putting the silk fiber solution into two dialysis bags with 3.5kDa, dialyzing for 72h at 4 ℃ to obtain pure fibroin, replacing dialysis water every 2h in the initial stage for four times continuously, replacing dialysis water every 8h later, obtaining fibroin dialysate after 72h, centrifuging for 30min at 14000rpm, and removing precipitate to obtain pure fibroin solution with solid content of 50 mg/mL;
2) weighing 1g radix rehmanniae Preparata, continuously adding water, and grinding under high pressure to obtain radix rehmanniae Preparata solution with solid content of 100mg/mL, as shown in FIG. 6, and storing at 4 deg.C for use;
3) according to the mass ratio of the fibroin solution to the prepared rehmannia root solution of 20: 1, and adding into 24-well plate at 300 μ L per well, freezing at-80 deg.C for 2h, and vacuum drying overnight to obtain wound healing preparation, as shown in FIG. 7.
The picture of the fibroin solution prepared in step 1) after vacuum drying is shown in fig. 5, and it can be known from fig. 5 that: the fibroin is white and transparent.
3. Study of wound healing formulations on wound healing conditions:
the wound healing preparation prepared by the method is used for scratching the wound of the skin of a mouse and has the optical density of 1W/cm under a near infrared laser with the wavelength of 808nm2Irradiating for 3min (test group), and irradiating without near infrared as control group;
1) the in vivo thermal imaging of the test group and the control group in the mice is shown in figure 8;
2) after successful wound modeling, the wounds of the mice 1 day after (next day) treatment in the control group and the experimental group are shown in fig. 9;
3) the HE staining pattern of the wound of the mice after six days of the mice treatment by the test group and the control group is shown in FIG. 10;
as can be seen from fig. 8: the wound healing preparation of the test group is continuously heated along with the prolonging of the irradiation time of the near infrared light, and can be precisely heated to 60 ℃ after being irradiated for 3min, the temperature can effectively promote the conversion of fibroin from an alpha-helix to a beta-folding configuration, the migration and growth of new epithelial cells are easily promoted, and the sterilization effect is achieved.
As can be seen from fig. 9: after the wound model was successfully modeled, the test and control mice were placed in the SPF animal room, and the wound was observed the next day as shown in fig. 9, where the wound of the test mice was severely infected with bacteria and the wound of the test mice was substantially sterile.
As can be seen from fig. 10: HE staining of the wounds (B in fig. 10) in the mice treated with the test group showed that both the epithelial tissue and the epidermal layer of the wounds were intact, indicating that the wounds had fully healed, while HE staining of the wounds (a in fig. 10) in the mice treated with the control group showed that the epithelial tissue and the epidermal layer of the wounds remained sectioned, indicating that the wounds in the control group did not fully heal.
Further, the results of the comparison of the wounds of the mice treated for 9 days in the test group and the control group are shown in fig. 11, and it can be seen from fig. 11 that the degree of wound healing of the mice treated by the test group is significantly better than that of the wounds of the mice treated by the control group.
Claims (9)
1. Application of black traditional Chinese medicine in preparing photothermal therapy preparation.
2. Use according to claim 1, characterized in that: the black traditional Chinese medicine is applied to the preparation of skin photothermal treatment preparations.
3. Use according to claim 2, characterized in that: the black traditional Chinese medicine is applied to preparing a skin wound photothermal treatment preparation.
4. Use according to any one of claims 1 to 3, characterized in that: the black Chinese medicine is at least one selected from Polygoni Multiflori radix, radix rehmanniae Preparata, Ganoderma extract, Cistanchis herba, caulis Sargentodoxae, radix Ginseng Indici, and fructus Nicandrae.
5. Use according to claim 4, characterized in that: the black Chinese medicine is at least one of radix rehmanniae Preparata, Ganoderma extract and Cistanchis herba.
6. Use according to any one of claims 1 to 3, characterized in that: the photothermal therapy preparation further comprises a pharmaceutically acceptable carrier, diluent, excipient or stabilizer.
7. Use according to any one of claims 1 to 3, characterized in that: the photothermal therapy preparation comprises black traditional Chinese medicine and fibroin.
8. Use according to claim 7, characterized in that: the mass ratio of the black traditional Chinese medicine to the fibroin is 1: 5-1: 50.
9. use according to claim 8, characterized in that: the mass ratio of the black traditional Chinese medicine to the fibroin is 1: 10-1: 30.
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| Application Number | Priority Date | Filing Date | Title |
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| CN202010440883.3A CN111569070A (en) | 2020-05-22 | 2020-05-22 | Application of black traditional Chinese medicine in preparation of photothermal therapy preparation |
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| CN202010440883.3A CN111569070A (en) | 2020-05-22 | 2020-05-22 | Application of black traditional Chinese medicine in preparation of photothermal therapy preparation |
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105267950A (en) * | 2015-10-16 | 2016-01-27 | 安柏希有限公司 | Composition for promoting wound healing |
| CN109701037A (en) * | 2019-01-23 | 2019-05-03 | 复旦大学 | A kind of biological ink and preparation method thereof with medical usage |
| CN109762100A (en) * | 2018-11-01 | 2019-05-17 | 扬州大学 | A kind of aloe-emodin/carbon nano-particle anti-bacterial hydrogel and preparation method thereof |
-
2020
- 2020-05-22 CN CN202010440883.3A patent/CN111569070A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105267950A (en) * | 2015-10-16 | 2016-01-27 | 安柏希有限公司 | Composition for promoting wound healing |
| CN109762100A (en) * | 2018-11-01 | 2019-05-17 | 扬州大学 | A kind of aloe-emodin/carbon nano-particle anti-bacterial hydrogel and preparation method thereof |
| CN109701037A (en) * | 2019-01-23 | 2019-05-03 | 复旦大学 | A kind of biological ink and preparation method thereof with medical usage |
Non-Patent Citations (5)
| Title |
|---|
| HASIM O. TABAKOGLU等: "Assessment of Circular Wound Healing in Rats After Exposure to 808-nm Laser Pulses During Specific Healing Phases", 《LASERS IN SURGERY AND MEDICINE》 * |
| LINGLING ZHANG等: "Photon-Responsive Antibacterial Nanoplatform for Synergistic Photothermal-/Pharmaco-Therapy of Skin Infection", 《ACS APPLIED MATERIALS & INTERFACES》 * |
| XIAOCHENG WANG等: "Defective Black Nano-Titania Thermogels for Cutaneous Tumor-Induced Therapy and Healing", 《NANO LETTERS》 * |
| 张慧媛等: "蚕丝的理化性质及其在食品中的应用", 《食品工业科技》 * |
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Application publication date: 20200825 |
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