CN111537578A - Electrochemical sensor material for detecting L-cysteine and preparation method thereof - Google Patents
Electrochemical sensor material for detecting L-cysteine and preparation method thereof Download PDFInfo
- Publication number
- CN111537578A CN111537578A CN202010310247.9A CN202010310247A CN111537578A CN 111537578 A CN111537578 A CN 111537578A CN 202010310247 A CN202010310247 A CN 202010310247A CN 111537578 A CN111537578 A CN 111537578A
- Authority
- CN
- China
- Prior art keywords
- solution
- bnc
- preparing
- electrochemical sensor
- sensor material
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Images
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
- G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
- G01N27/28—Electrolytic cell components
- G01N27/30—Electrodes, e.g. test electrodes; Half-cells
- G01N27/308—Electrodes, e.g. test electrodes; Half-cells at least partially made of carbon
-
- C—CHEMISTRY; METALLURGY
- C01—INORGANIC CHEMISTRY
- C01B—NON-METALLIC ELEMENTS; COMPOUNDS THEREOF; METALLOIDS OR COMPOUNDS THEREOF NOT COVERED BY SUBCLASS C01C
- C01B32/00—Carbon; Compounds thereof
- C01B32/15—Nano-sized carbon materials
- C01B32/158—Carbon nanotubes
- C01B32/16—Preparation
-
- C—CHEMISTRY; METALLURGY
- C01—INORGANIC CHEMISTRY
- C01B—NON-METALLIC ELEMENTS; COMPOUNDS THEREOF; METALLOIDS OR COMPOUNDS THEREOF NOT COVERED BY SUBCLASS C01C
- C01B32/00—Carbon; Compounds thereof
- C01B32/15—Nano-sized carbon materials
- C01B32/158—Carbon nanotubes
- C01B32/168—After-treatment
Landscapes
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Nanotechnology (AREA)
- Materials Engineering (AREA)
- Life Sciences & Earth Sciences (AREA)
- Inorganic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Electrochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Biochemistry (AREA)
- Analytical Chemistry (AREA)
- Physics & Mathematics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Molecular Biology (AREA)
- Measuring Oxygen Concentration In Cells (AREA)
- Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
Abstract
The invention discloses a preparation method of an electrochemical sensor material for detecting L-cysteine, which comprises the following steps: (1) GF pretreatment; (2) preparing BNC; (3) preparing a PB growth solution; (4) preparing BNC/GF; (5) BNC @ PB/GF and provides the products obtained by the method. The method can obtain the electrode material with excellent electrochemical characteristics, overcomes the defects of low sensitivity and high detection limit of the conventional L-cysteine electrochemical sensor, realizes the advantages of low detection limit, high sensitivity, wide linear range and high stability, and is simple, rapid and easy to control.
Description
Technical Field
The invention belongs to the technical field of electrochemical sensors, and particularly relates to an electrochemical sensor material for detecting L-cysteine and a preparation method thereof.
Background
L-cysteine (L-cys), one of the most important thiol-containing amino acids, plays a crucial role in biological systems and can be used for the diagnosis of disease states.
L-cys has been used in the food and pharmaceutical industries as an antioxidant, antitoxin, radioprotectant, cancer indicator and free radical scavenger. Deficiency of L-cys is associated with slow growth, diabetes, alopecia, skin disorders, and susceptibility to fatigue.
At present, the detection method of L-cys mainly comprises chromatographic separation, atomic absorption spectroscopy, atomic emission spectroscopy, capillary electrophoresis, electrochemical methods and the like. Among them, the electrochemical method is preferred because of its advantages such as easy operation and low cost.
Disclosure of Invention
The first purpose of the invention is to provide a preparation method of an electrochemical sensor material for detecting L-cysteine, by which an electrode material with uniform appearance and stable structure can be obtained, the electrode material has good conductivity and catalytic performance, the prepared sensor has the advantages of high sensitivity, low detection limit and the like, and the preparation method is simple and easy to control.
It is a second object of the present invention to provide an electrochemical sensor material obtained according to the above method.
The purpose of the invention is realized by the following technical scheme:
a preparation method of an electrochemical sensor material for detecting L-cysteine comprises the following steps:
(1) GF pretreatment, cutting a graphite felt GF, alternately washing the graphite felt with ultrapure water and methanol to remove surface residues, vacuum-drying overnight, then activating with a sulfuric acid solution, washing with ultrapure water, and vacuum-drying overnight;
(2) preparing BNC, namely dispersing boric acid, urea and polyethylene glycol into ultrapure water, ultrasonically dissolving, drying at 80 ℃ to obtain powder, placing the obtained powder into a porcelain boat, preserving heat at 900 ℃ in Ar atmosphere, and naturally cooling after heat preservation to obtain boron-nitrogen doped carbon nanotube BNC powder;
(3) preparing a PB growth solution, wherein the PB growth solution comprises a solution A and a solution B, and the solution A contains K3[Fe(CN)6]The solution B contains FeCl3KCl and HCl;
(4) preparing BNC/GF, namely dissolving the boron-nitrogen doped carbon nanotube powder prepared in the step (2) in ultrapure water to obtain a BNC aqueous solution, adding the graphite felt pretreated in the step (1), carrying out ultrasonic treatment, then washing the graphite felt with the ultrapure water, and carrying out vacuum drying overnight to obtain BNC/GF;
(5) and (3) preparing BNC @ PB/GF, mixing the solution A and the solution B which are prepared in step (3), adding the BNC/GF obtained in step (4), growing at room temperature, cleaning the surface of the graphite felt with ultrapure water, and drying in vacuum overnight to obtain the product.
Preferably, in the step (1), the temperature of vacuum drying is 60 ℃, the sulfuric acid solution is formed by mixing 98% sulfuric acid and ultrapure water in a volume ratio of 1:1, and the activation time is 1 h.
Preferably, in the step (2), the weight ratio of the boric acid to the urea to the polyethylene glycol is 0.15:10:1, the drying time is 10 hours, and the holding time at 900 ℃ is 4 hours.
Preferably, in step (3), the solution A contains 2.0mmol/L K3[Fe(CN)6]The solution B contains 2.0mmol/LFeCl3、0.2mol/L KCl、0.05mmol/L HCl。
Preferably, in the step (4), the concentration of the BNC aqueous solution is 0.1-1.0mg/mL, the ultrasonic time is 30min, and the vacuum drying temperature is 60 ℃.
Further preferably, the concentration of the BNC aqueous solution is 0.5 mg/mL.
Preferably, in the step (5), the volume ratio of the solution A to the solution B is 1:1, the volume ratio of the solution A to the solution B to the BNC aqueous solution in the step (4) is 1:1, the room-temperature growth time is 5-60min, and the vacuum drying temperature is 60 ℃.
Further preferably, the room temperature growth time is 30 min.
An electrochemical sensor material for the detection of L-cysteine obtained by any of the above methods.
Prussian Blue (PB) is a typical hexacyanoferrate coordination compound, and has attracted wide attention in the fields of medicines and materials due to the characteristics of no pollution, low cost, easy preparation, excellent electrochemical performance and the like. Fe in PB2+And Fe3+Reversible electrochemical redox promotes electron transport and enhances the electrochemical performance of the electrode material.
Carbon nanotubes are typical carbon materials and have high specific surface area, excellent electrical conductivity, excellent stability, and characteristics of simple preparation, low price, and corrosion resistance. Furthermore, heteroatom doping is one of the effective methods to modulate the properties of carbon nanostructures. Of the various heteroatoms, nitrogen and boron are excellent dopants for carbon-based materials because the atomic sizes of boron, carbon and nitrogen are the closest.
The invention combines the advantages of heteroatom-doped carbon nanotubes and Prussian blue for the first time, prepares the composite electrode by taking the graphite felt GF as an electrode substrate material, overcomes the defects of high detection limit, poor reproducibility, low sensitivity and narrow linear range of the conventional electrochemical detection of L-cys, and realizes the high-efficiency detection of the L-cys.
The invention has the following beneficial effects:
according to the preparation method of the electrochemical sensor material for detecting the L-cysteine, the BNC @ PB/GF composite electrode can exert the advantages of the three components, and the conductivity, the stability and the electrochemical response of the composite material are enhanced by the synergistic effect of the components; the method can prepare the nanometer material with uniform appearance; the combination of BNC and GF and the in-situ growth process of PB reduces the consumption of raw materials and greatly improves the preparation efficiency; the composite electrode pair L-cys can be carried out under neutral medium and low potential, and has the advantages of good detection sensitivity, circulation stability, anti-interference performance, high sample recovery rate and the like.
Drawings
FIG. 1 is an SEM image of BNC (left panel) and BNC @ PB (right panel) prepared in example 1.
FIG. 2 is a graph showing the potential optimization and quantification curves of the BNC @ PB/GF electrode prepared in example 1 for L-cys detection, wherein A is a CV curve of the electrode BNC @ PB/GF with or without L-cys; b is an i-t curve of the electrode BNC @ PB/GF responding to L-cys at different potentials; c is a current response curve of the electrode BNC @ PB/GF continuously adding L-cys with different concentrations; d is a current concentration linear curve.
FIG. 3 shows the anti-interference capability and long-term stability of the BNC @ PB/GF electrode prepared in example 1 for detecting L-cys, wherein A is the anti-interference detection curve of the electrode BNC @ PB/GF for detecting L-cys; and B is an electrode BNC @ PB/GF detection L-cys stability test.
FIG. 4A is a CV curve of GF, PB/GF, BNC @ PB/GF of different electrodes prepared in example 1; b is a partial enlarged view of A; c and D are CV curves of different BNC concentrations and different growth times in the preparation process of the electrode BNC @ PB/GF respectively.
Detailed Description
The following description of the preferred embodiments of the present invention is provided for the purpose of illustration and description, and is in no way intended to limit the invention.
The raw materials in the following examples are all commercially available products. Wherein the graphite felt GF is purchased from Hehis carbon fiber Limited, Gansu, and has a thickness of 3 mm; boric acid was purchased from Tianjin optical science and technology development Limited; urea was purchased from tianjin shin science and technology development ltd; polyethylene glycol was purchased from Shanghai Aladdin science and technology, Inc.
Example 1
A preparation method of a BNC @ PB/GF composite electrode material comprises the following steps:
(1) GF pretreatment
Cutting GF into 2 cm-1 mm sheets, washing away surface scum of the cut GF with ultrapure water, washing with methanol and ultrapure water alternately until no scum is formed, and vacuum drying at 60 deg.c overnight; 30-50 pieces of cleaned GF are selected and put into 200ml of sulfuric acid: water 1: 1(v/v), then washed to neutrality with ultrapure water, and dried overnight under vacuum at 60 ℃.
(2) Preparation of BNC
Dispersing 0.15g of boric acid, 5g of urea and 0.5g of polyethylene glycol into 50mL of ultrapure water, ultrasonically dissolving for 10min, placing in an oven at 80 ℃ for 10h, placing the obtained white powder in a porcelain boat, keeping the white powder for 4h under Ar atmosphere and 900 ℃ (the heating rate is 5 ℃/min), and naturally cooling under Ar atmosphere to obtain black BNC powder.
(3) Preparation of PB growth liquid
The solution A contains 2mmol/L K3[Fe(CN)6]The solution B contains 2.0mmol/L FeCl30.2mol/LKCl and 0.05mmol/LHCl, and mixing the solution A and the solution B in equal volume to obtain the PB growth solution.
(4) Preparation of BNC/GF
And (3) putting 1.6mL of BNC aqueous solution with the concentration of 0.5mg/mL into a 7mL centrifuge tube, putting the GF pretreated in the step (1), carrying out ultrasonic bath for 30min, washing the surface of the GF with ultrapure water, and carrying out vacuum drying at 60 ℃ overnight.
(5) Preparation of BNC @ PB/GF
Mixing the solution A and the solution B in the step (3) in equal volume to obtain PB growth solution, and taking 1.6mL of freshly prepared PB growth solution (containing 1.0mmol/L K)3[Fe(CN)6]，1.0mmol/LFeCl30.1mol/L KCl and 0.025mmol/L HCl) into a 7ml centrifuge tube, putting the BNC/GF prepared in the step (4), growing for 30min at room temperature, washing the surface of the GF with ultrapure water, and drying overnight under vacuum at 60 ℃ to obtain the product.
Example 2
The preparation method of the BNC/GF and PB/GF composite electrode material comprises the following steps:
(1) GF pretreatment was carried out in the same manner as in step (1) of example 1.
(2) BNC/GF was prepared according to the same procedure as in step (4) of example 1.
(3) PB/GF was prepared according to the same procedure as in step (5) of example 1, except that BNC/GF was not incorporated and GF pretreated in step (1) was incorporated.
Example 3
A preparation method of a BNC @ PB/GF composite electrode material is characterized in that 1.6mL of 0.1mg/mL BNC solution is taken in the step (4), and the rest is the same as that in the example 1.
Example 4
A preparation method of a BNC @ PB/GF composite electrode material is characterized in that 1.6mL of 1.0mg/mL BNC solution is taken in the step (4), and the rest is the same as that in the example 1.
Example 5
A preparation method of a BNC @ PB/GF composite electrode material is characterized in that the PB nano particle growth time in the step (5) is 5min, and the rest is the same as that in the example 1.
Example 6
A preparation method of a BNC @ PB/GF composite electrode material is characterized in that the PB nano particle growth time in the step (5) is 15min, and the rest is the same as that in the example 1.
Example 7
A preparation method of a BNC @ PB/GF composite electrode material is characterized in that the PB nano particle growth time in the step (5) is 60min, and the rest is the same as that in the example 1.
The effect test of the composite electrode material prepared in the above example has the following results:
electrochemical performance tests are carried out on the electrodes GF, BNC/GF, PB/GF and BNC @ PB/GF by Cyclic Voltammetry (CV), which are shown in fig. 4A and 4B, wherein GF and CV of BNC/GF do not generate peaks and are overlapped under the current icon degree in fig. 4A, and the GF and CV of BNC/GF can be distinguished after being locally enlarged in fig. 4B. The result shows that the BNC @ PB/GF electrode has stronger current response signals, better electrochemical reversibility and cycle stability.
In order to optimize the preparation conditions of the composite electrode, electrochemical performance tests were performed using Cyclic Voltammetry (CV), see fig. 4C, 4D. The result shows that when the BNC solution concentration is 0.5mg/ml and the PB growth time is 30min, the prepared electrode has better electrochemical performance.
The detection potential of the BNC @ PB/GF composite electrode pair for L-cys detection is optimized by a Chronoamperometry (CA) as shown in FIG. 2B. Experiments prove that BNC @ PB/GF shows stronger current response to L-cys at the potential of 0.24V.
The linear range, the sensitivity and the lowest detection limit of the L-cys detected by the BNC @ PB/GF composite electrode are researched by a timing current method (CA) and a standard addition method. The optimized result is linear range of 0.0055-4177 mu M, sensitivity of 0.21A/M and minimum detection limit of 1.1 nM.
In summary, the electrochemical sensor material for detecting L-cysteine obtained by the method of the present invention has a linear response range of 0.0055-4177 μ M to L-cys, a sensitivity of 0.21A/M, and a minimum detection limit of 1.1nM (S/N-3).
The electrochemical sensor material prepared by the invention realizes the high-efficiency detection of L-cys and provides a feasible idea for the detection of L-cys.
Detection test
The electrochemical sensor of the composite electrode material of the embodiment 1 of the invention is used for detecting L-cys in serum (fetal bovine serum, Hangzhou Biotechnology GmbH in Zhejiang, Zhejiang) and tablets (cysteine Capsule brand: Puritan's Pride), and the method is a standard addition method and is specifically operated as follows: firstly, diluting serum, preparing an L-cys serum solution, and detecting the content of L-cys in the L-cys serum solution by using an electrode BNC @ PB/GF; quantitatively weighing the L-cys capsules, preparing an aqueous solution with a certain concentration, detecting the L-cys content in the L-cys tablet solution by using an electrode BNC @ PB/GF, and comparing the measured content with the label content to calculate the recovery rate. The results are shown in the following table.
| Sample (I) | Label content (μ M) | Assay (μ M) | Recovery (%) |
| #1 (serum) | 25 | 24.6 | 98.5 |
| #2 (serum) | 25 | 24.3 | 97.2 |
| #3 (serum) | 25 | 24.6 | 98.5 |
| #4 (tablet) | 25 | 25.9 | 103.6 |
| #5 (tablet) | 25 | 24.4 | 97.6 |
| #6 (tablet) | 25 | 24.9 | 99.6 |
Although the present invention has been described in detail with reference to the foregoing embodiments, it will be apparent to those skilled in the art that changes may be made in the embodiments and/or equivalents thereof without departing from the spirit and scope of the invention. Any modification, equivalent replacement, or improvement made within the spirit and principle of the present invention should be included in the protection scope of the present invention.
Claims (9)
1. A preparation method of an electrochemical sensor material for detecting L-cysteine is characterized by comprising the following steps:
(1) GF pretreatment, cutting the graphite felt, alternately washing the graphite felt with ultrapure water and methanol to remove surface residues, vacuum-drying overnight, then activating with sulfuric acid solution, washing with ultrapure water, and vacuum-drying overnight;
(2) preparing BNC, dispersing boric acid, urea and polyethylene glycol into ultrapure water, ultrasonically dissolving, drying at 80 ℃ to obtain powder, placing the obtained powder into a porcelain boat, preserving heat at 900 ℃ in Ar atmosphere, and naturally cooling after heat preservation to obtain boron-nitrogen doped carbon nanotube powder;
(3) preparing a PB growth solution, wherein the PB growth solution comprises a solution A and a solution B, and the solution A contains K3[Fe(CN)6]The solution B contains FeCl3KCl and HCl;
(4) preparing BNC/GF, namely dissolving the boron-nitrogen doped carbon nanotube powder prepared in the step (2) in ultrapure water to obtain a BNC aqueous solution, adding the graphite felt pretreated in the step (1), carrying out ultrasonic treatment, then washing the graphite felt with the ultrapure water, and carrying out vacuum drying overnight to obtain BNC/GF;
(5) and (3) preparing BNC @ PB/GF, mixing the solution A and the solution B which are prepared in step (3), adding the BNC/GF obtained in step (4), growing at room temperature, cleaning the surface of the graphite felt with ultrapure water, and drying in vacuum overnight to obtain the product.
2. The method for preparing an electrochemical sensor material for L-cysteine detection according to claim 1, wherein in step (1), the vacuum drying temperature is 60 ℃, the sulfuric acid solution is formed by mixing 98% sulfuric acid and ultrapure water in a volume ratio of 1:1, and the activation time is 1 h.
3. The method for preparing an electrochemical sensor material for L-cysteine detection according to claim 1, wherein in the step (2), the weight ratio of the boric acid to the urea to the polyethylene glycol is 0.15:10:1, the drying time is 10h, and the holding time at 900 ℃ is 4 h.
4. The method for preparing an electrochemical sensor material for L-cysteine detection according to claim 1, wherein in the step (3), the solution A contains 2.0mmol/L K3[Fe(CN)6]The solution B contains 2.0mmol/L FeCl3、0.2mol/L KCl、0.05mmol/L HCl。
5. The method for preparing an electrochemical sensor material for L-cysteine detection according to claim 1, wherein in the step (4), the BNC aqueous solution has a concentration of 0.1-1.0mg/mL, an ultrasonic time of 30min, and a vacuum drying temperature of 60 ℃.
6. The method for preparing an electrochemical sensor material for L-cysteine detection according to claim 5, wherein the concentration of the BNC aqueous solution is 0.5 mg/mL.
7. The method for preparing an electrochemical sensor material for L-cysteine detection according to claim 1 wherein in step (5), the volume ratio of the solution A and the solution B is 1:1, the volume ratio of the solution A and the solution B to the BNC aqueous solution in step (4) is 1:1, the room temperature growth time is 5-60min, and the vacuum drying temperature is 60 ℃.
8. The method for preparing an electrochemical sensor material for L-cysteine detection according to claim 7, wherein the growth time at room temperature is 30 min.
9. An electrochemical sensor material for the detection of L-cysteine obtained according to the method of any one of claims 1 to 8.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202010310247.9A CN111537578B (en) | 2020-04-20 | 2020-04-20 | Electrochemical sensor material for detecting L-cysteine and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202010310247.9A CN111537578B (en) | 2020-04-20 | 2020-04-20 | Electrochemical sensor material for detecting L-cysteine and preparation method thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN111537578A true CN111537578A (en) | 2020-08-14 |
| CN111537578B CN111537578B (en) | 2022-12-13 |
Family
ID=71972976
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202010310247.9A Active CN111537578B (en) | 2020-04-20 | 2020-04-20 | Electrochemical sensor material for detecting L-cysteine and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN111537578B (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112240899A (en) * | 2020-08-25 | 2021-01-19 | 兰州大学 | Prussian blue/molybdenum selenide-based dopamine sensor material and preparation method thereof |
| CN114674908A (en) * | 2021-11-25 | 2022-06-28 | 兰州大学 | Preparation method of electrochemical sensor for tigecycline detection |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102945905A (en) * | 2012-11-28 | 2013-02-27 | 中国科学院物理研究所 | Visible light emitting diode based on boron carbon nitrogen nanometer tube |
| CN106290519A (en) * | 2016-08-30 | 2017-01-04 | 上海大学 | Nitrogen-doped carbon nanometer pipe is combined the preparation method and applications of the glass-carbon electrode of L cysteine modified |
| US20190186029A1 (en) * | 2017-08-03 | 2019-06-20 | Dalian Institute Of Chemical Physics, Chinese Academy Of Sciences | Graphene material inlaid with single metal atoms and preparing method and application thereof |
| CN110280292A (en) * | 2019-07-09 | 2019-09-27 | 浙江工业大学 | A kind of compound Pt nanoparticle and metal nitride materials catalyst and its preparation method and application |
| CN110648854A (en) * | 2019-09-23 | 2020-01-03 | 东华大学 | Boron-nitrogen co-doped carbon/manganese oxide composite nanosheet material, and preparation method and application thereof |
-
2020
- 2020-04-20 CN CN202010310247.9A patent/CN111537578B/en active Active
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102945905A (en) * | 2012-11-28 | 2013-02-27 | 中国科学院物理研究所 | Visible light emitting diode based on boron carbon nitrogen nanometer tube |
| CN106290519A (en) * | 2016-08-30 | 2017-01-04 | 上海大学 | Nitrogen-doped carbon nanometer pipe is combined the preparation method and applications of the glass-carbon electrode of L cysteine modified |
| US20190186029A1 (en) * | 2017-08-03 | 2019-06-20 | Dalian Institute Of Chemical Physics, Chinese Academy Of Sciences | Graphene material inlaid with single metal atoms and preparing method and application thereof |
| CN110280292A (en) * | 2019-07-09 | 2019-09-27 | 浙江工业大学 | A kind of compound Pt nanoparticle and metal nitride materials catalyst and its preparation method and application |
| CN110648854A (en) * | 2019-09-23 | 2020-01-03 | 东华大学 | Boron-nitrogen co-doped carbon/manganese oxide composite nanosheet material, and preparation method and application thereof |
Non-Patent Citations (4)
| Title |
|---|
| DENG CHUNYAN等: "Electrochemical detection of L-cysteine using a boron-doped carbon nanotube-modified electrode", 《ELECTROCHIMICA ACTA》 * |
| SHI ZHUANZHUAN等: "Atomic matching catalysis to realize a highly selective and sensitive biomimetic uric acid sensor", 《BIOSENSORS & BIOELECTRONICS》 * |
| TABASSUM HASSINA等: "Metal-organic frameworks derived cobalt phosphide architecture encapsulated into B/N Co-doped graphene nanotubes for all pH value electrochemical hydrogen evolution", 《ADVANCED ENERGY MATERIALS》 * |
| 王蕾: "普鲁士蓝、金属氧化物复合电极材料的制备及其在电化学催化中的应用研究", 《中国优秀博硕士学位论文全文数据库(硕士)工程科技Ⅰ辑》 * |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112240899A (en) * | 2020-08-25 | 2021-01-19 | 兰州大学 | Prussian blue/molybdenum selenide-based dopamine sensor material and preparation method thereof |
| CN112240899B (en) * | 2020-08-25 | 2023-03-31 | 兰州大学 | Prussian blue/molybdenum selenide-based dopamine sensor material and preparation method thereof |
| CN114674908A (en) * | 2021-11-25 | 2022-06-28 | 兰州大学 | Preparation method of electrochemical sensor for tigecycline detection |
Also Published As
| Publication number | Publication date |
|---|---|
| CN111537578B (en) | 2022-12-13 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| Ge et al. | Facile one-pot synthesis of visible light-responsive BiPO4/nitrogen doped graphene hydrogel for fabricating label-free photoelectrochemical tetracycline aptasensor | |
| Hao et al. | Multiple signal-amplification via Ag and TiO2 decorated 3D nitrogen doped graphene hydrogel for fabricating sensitive label-free photoelectrochemical thrombin aptasensor | |
| Fu et al. | A glassy carbon electrode modified with N-doped carbon dots for improved detection of hydrogen peroxide and paracetamol | |
| Xiao et al. | Highly sensitive electrochemical sensor for chloramphenicol based on MOF derived exfoliated porous carbon | |
| Li et al. | Ag/N-doped reduced graphene oxide incorporated with molecularly imprinted polymer: an advanced electrochemical sensing platform for salbutamol determination | |
| Chen et al. | A high performance electrochemical sensor for acetaminophen based on single-walled carbon nanotube–graphene nanosheet hybrid films | |
| Wu et al. | Electrochemical sensor for toxic ractopamine and clenbuterol based on the enhancement effect of graphene oxide | |
| Huang et al. | Three-dimensional porous high boron-nitrogen-doped carbon for the ultrasensitive electrochemical detection of trace heavy metals in food samples | |
| Sun et al. | Ultrasensitive photoelectrochemical immunoassay of indole-3-acetic acid based on the MPA modified CdS/RGO nanocomposites decorated ITO electrode | |
| CN111537578B (en) | Electrochemical sensor material for detecting L-cysteine and preparation method thereof | |
| Wang et al. | Nanohybrid of Co3O4 and histidine-functionalized graphene quantum dots for electrochemical detection of hydroquinone | |
| Li et al. | Au-Pt bimetallic nanoparticles supported on functionalized nitrogen-doped graphene for sensitive detection of nitrite | |
| Yang et al. | A novel tyrosinase biosensor based on chitosan-carbon-coated nickel nanocomposite film | |
| Zhang et al. | A nitrogen-doped carbon dot/ferrocene@ β-cyclodextrin composite as an enhanced material for sensitive and selective determination of uric acid | |
| Zhou et al. | Two-dimensional black phosphorus/tin oxide heterojunctions for high-performance chemiresistive H2S sensing | |
| Ren et al. | Amperometric glucose biosensor based on a gold nanorods/cellulose acetate composite film as immobilization matrix | |
| Niu et al. | Fabrication of an electrochemical chiral sensor via an integrated polysaccharides/3D nitrogen-doped graphene-CNT frame | |
| Wang et al. | Graphitic carbon nitride nanosheets modified multi-walled carbon nanotubes as 3D high efficient sensor for simultaneous determination of dopamine, uric acid and tryptophan | |
| Luo et al. | One-step preparation of Ag nanoparticle–decorated coordination polymer nanobelts and their application for enzymeless H2O2 detection | |
| Zheng et al. | Selective and simultaneous determination of hydroquinone and catechol by using a nitrogen-doped bagasse activated carbon modified electrode | |
| Chen et al. | Imidazoline derivative templated synthesis of broccoli-like Bi2S3 and its electrocatalysis towards the direct electrochemistry of hemoglobin | |
| Sun et al. | Novel in-situ deposited V2O5 nanorods array film sensor with enhanced gas sensing performance to n-butylamine | |
| Zheng et al. | Studies on electrochemical organophosphate pesticide (OP) biosensor design based on ionic liquid functionalized graphene and a Co 3 O 4 nanoparticle modified electrode | |
| Li et al. | Simultaneous voltammetric determination of ascorbic acid and uric acid using a Nafion/multi-wall carbon nanotubes composite film-modified electrode | |
| Huang et al. | A light-driven enzyme-free photoelectrochemical sensor based on HKUST-1 derived Cu2O/Cu@ microporous carbon with g-C3N4 pn heterojunction for ultra-sensitive detection of l-cysteine |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant |