CN111529045A - Freeze ablation system and freeze ablation method without interrupting blood flow - Google Patents
Freeze ablation system and freeze ablation method without interrupting blood flow Download PDFInfo
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- CN111529045A CN111529045A CN202010326311.2A CN202010326311A CN111529045A CN 111529045 A CN111529045 A CN 111529045A CN 202010326311 A CN202010326311 A CN 202010326311A CN 111529045 A CN111529045 A CN 111529045A
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- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B18/02—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by cooling, e.g. cryogenic techniques
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- A61B6/00—Apparatus or devices for radiation diagnosis; Apparatus or devices for radiation diagnosis combined with radiation therapy equipment
- A61B6/48—Diagnostic techniques
- A61B6/481—Diagnostic techniques involving the use of contrast agents
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- A61B6/50—Apparatus or devices for radiation diagnosis; Apparatus or devices for radiation diagnosis combined with radiation therapy equipment specially adapted for specific body parts; specially adapted for specific clinical applications
- A61B6/504—Apparatus or devices for radiation diagnosis; Apparatus or devices for radiation diagnosis combined with radiation therapy equipment specially adapted for specific body parts; specially adapted for specific clinical applications for diagnosis of blood vessels, e.g. by angiography
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- A61B2018/00053—Mechanical features of the instrument of device
- A61B2018/00214—Expandable means emitting energy, e.g. by elements carried thereon
- A61B2018/0022—Balloons
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- A61B18/02—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by cooling, e.g. cryogenic techniques
- A61B2018/0212—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by cooling, e.g. cryogenic techniques using an instrument inserted into a body lumen, e.g. catheter
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- A—HUMAN NECESSITIES
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- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B18/02—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by cooling, e.g. cryogenic techniques
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Abstract
The invention relates to a blood flow uninterrupted cryoablation system, which comprises a balloon catheter, a stent catheter and a guide wire, wherein the balloon catheter is connected with the stent catheter through the guide wire; the sacculus pipe connects and the handle including the dysmorphism sacculus, pipe, the injection that connect gradually, divide into three inner chamber in the dysmorphism sacculus and connect and be connected with the handle through pipe and injection respectively, the support pipe includes the inside push rod that is equipped with the seal wire chamber, the push rod includes bracket component, inner tube, outer sheath pipe and sealed switch, the seal wire is including being located a seal wire front end preforming structure. The invention improves the guiding insertion of the cryoablation system through the guide wire, and forms a stable channel on the inner side of the balloon through the support of the bracket component, thereby avoiding the vascular embolism caused by the expansion and compression of the balloon, simultaneously continuously inputting liquid nitrogen under the condition of not interrupting blood flow, repeatedly and circularly extracting and injecting the liquid nitrogen, and avoiding the consequences of far-end severe ischemia and the like caused by target vascular occlusion in the operation.
Description
Technical Field
The invention relates to the technology of medical instruments, is applied to cardio-thoracic vascular intervention operations, and particularly relates to a system and a method for cryoablation without interrupting blood flow.
Technical Field
When atrial fibrillation cryoballoon ablation is clinically carried out, a catheter is generally conveyed to a target pulmonary vein through atrial septal puncture, and a cryoablation instrument conveys liquid N2O to an inner-layer balloon of the balloon catheter through a coaxial connecting cable and a superfine lumen (injection tube) of a cryoablation catheter body. After balloon blocking conditions are determined through balloon inflation and positioning X-ray, ablation is carried out, liquid N2O in the balloon is gasified during ablation, heat of surrounding tissues is absorbed, and the target tissues are rapidly frozen to achieve ablation effect. Wherein the cryoablation instrument controls the safe delivery and the evacuation of N2O, and gaseous N2O is evacuated back to the cryoablation instrument by negative pressure vacuum and finally exhausted through a hospital exhaust system in the form of tail gas.
Currently, the cryoballoon widely used in clinic only aims at pulmonary vein potential isolation of atrial fibrillation, so that an ablated target blood vessel only aims at a pulmonary vein, and the cryoballoon cannot be widely applied to blood vessel cryoablation in other fields (such as renal artery, pulmonary artery and branch artery thereof), and the main limiting factors include: 1. during cryoablation, the larger the contact area between the head end (i.e. the balloon) of the catheter and tissues is required to be, the more the heat is removed, so that the blood flow of a target blood vessel needs to be interrupted during ablation by the traditional cryoballoon, and artificial embolism is easily caused during the ablation of the target blood vessels such as renal artery, pulmonary artery and branch artery thereof; 2. the main limitation of the traditional cryoablation therapy is narrow adaptation, and the traditional cryoballoon catheter is designed specially for the pulmonary vein anatomical structure and is mainly applied to pulmonary vein isolation at present. For patients with paroxysmal atrial fibrillation with trigger focuses (such as superior vena cava, coronary sinus ostia and the like) originated from non-pulmonary veins, other ablation catheters can be only adopted for ablation; 3. at present, ablation treatment for removing pulmonary artery sympathetic activation is only point-to-point radio frequency ablation, ablation and ending are limited, and the slice injury of the traditional freezing saccule cannot be applied to removing pulmonary artery sympathetic activation to treat pulmonary hypertension due to a plurality of limitations; 4. at present, point-to-point radio frequency ablation is mostly used for treating hypertension, heart failure and the like by renal sympathetic ablation, severe complications such as severe pain in the operation are often combined, and an effective monitorable end point in the operation does not exist, but the sheet injury of the traditional freezing saccule cannot be applied to the sympathetic ablation treatment of the renal artery due to a plurality of limitations; 5. the traditional balloon is in a spherical structure instead of a tubular structure, is limited to the mouth of a target blood vessel in the ablation operation, and cannot perform the ablation of the far end of the blood vessel. 6. The catheter is not provided with the blood flow guide hole and the catheter, so that the catheter has no suction or injection function. After the sheath is delivered into the target blood vessel, air bubbles or thrombus possibly existing in the sheath cannot be sucked, anticoagulant (such as heparin saline) and other therapeutic drugs cannot be injected into the sheath, and real-time angiography cannot be realized.
Disclosure of Invention
In order to solve the problems, the invention provides a blood flow uninterrupted cryoablation system and a cryoablation method, and the technical scheme adopted by the invention is as follows:
a cryoablation system without interrupting blood flow comprises a balloon catheter, a stent catheter and a guide wire, wherein the balloon catheter is connected with the stent catheter through the guide wire;
the balloon catheter comprises a special-shaped balloon, a catheter, an injection joint and a handle which are sequentially connected, wherein a special-shaped guide hole used for being connected with a guide wire is formed in the special-shaped balloon, so that blood flow guiding can be realized while cryoablation of a focus position is met, relative occlusion of an ablation target blood vessel is prevented, and the special-shaped balloon is also used as the guide hole of the guide wire in a folded state to realize guided insertion of the balloon catheter. The front and the back of the inside of the balloon are respectively provided with a developing ring, so that the position of the balloon can be identified in radiography, the inside of the special-shaped balloon is divided into three inner cavities which are respectively connected with an injection joint and a handle through a catheter, the two inner cavities connected with the handle are respectively an injection cavity and an output cavity of liquid nitrogen, the handle can be used for controlling the injection and the output of the liquid nitrogen, the continuous expansion of a balloon body and the continuous cryoablation of a vessel wall are realized by controlling the flow, and the inner cavity connected with the injection joint is a contrast agent injection cavity which can inject a contrast agent;
the bracket guide pipe comprises a push rod with a wire guide cavity arranged inside, the push rod comprises a bracket component, an inner pipe, an outer sheath pipe and a sealing switch, the bracket component is positioned at the front end of the push rod and is provided with a developing ring, the sealing switch is arranged at the rear end of the push rod, the inner pipe is connected with the bracket component, the outer sheath pipe is arranged on the outer sides of the inner pipe and the bracket component, the other end of the inner pipe is provided with a push block and a stop switch, and the front and back extension and contraction of the bracket are realized by pushing the inner pipe;
the guidewire includes a preformed structure at the leading end of the guidewire for facilitating navigation into a target vessel during insertion.
Furthermore, a switch valve is arranged on the injection joint at the tail end of the balloon catheter and used for injecting contrast medium and avoiding blood backflow.
Further, the bracket component has included a plurality of fixed supports of stack around for increase the supporting effect, avoid sacculus expansion back, inside dysmorphism bullport is influenced by pressure and is blockked up, thereby influences the blood and flows, simultaneously when propelling movement push-and-pull rod, can realize the linkage from beginning to end between each support, the development ring is installed in every the inside rear end of support can realize the development location of support, spacing when can realizing the support again and strut.
Furthermore, the stent is made of nickel-titanium alloy and is shaped through heat treatment so as to realize free distraction in the operation.
Furthermore, a fastening device is arranged in a stop switch on the inner pipe of the bracket conduit and is used for keeping the support or forward extension state of the bracket to be continuously effective.
Furthermore, the inner tube of the stent catheter is provided with a color ring mark for judging whether the stent component is fully retracted into the outer sheath tube or not by identifying the position of the color ring in the process of pushing the outer sheath tube.
Furthermore, the pushing rod of the stent catheter is made of a high polymer material with certain rigidity and flexibility, so that the stent catheter is smoothly bent in the insertion process and the function of pushing the stent component can be realized.
Further, the sealing switch of support pipe in be provided with the silica gel cushion for after inserting to the focus position, the sealed switch of screwing, inside silica gel cushion can realize the terminal sealing in pipe chamber, avoids the blood backward flow.
Furthermore, the outer side of the rear end of the inner tube of the stent catheter is provided with a position indicating point for identifying whether the stent component is fully recovered or released.
In another aspect of the present invention, a cryoablation method using the above-mentioned blood flow uninterrupted cryoablation system is further included, which includes the following steps:
s1, guiding a stent catheter into a balloon catheter through a guide wire, wherein a stent component is positioned at a special-shaped balloon;
s2, a push rod on the stent catheter is pushed, the stent component is pushed by an inner tube of the push rod and is changed from a forward extending state to a supporting state, so that a special-shaped balloon of the balloon catheter is deformed, a stable channel is formed through a stop switch, and the balloon is prevented from expanding;
s3, the liquid nitrogen is repeatedly and circularly pumped out and injected into the injection cavity and the output cavity of the liquid nitrogen through the handle continuity of the balloon catheter, the handle is connected with the balloon liquid nitrogen injection cavity and the output cavity of the balloon catheter through the catheter, the balloon body volume and the continuous cryoablation on the vascular wall are controlled by controlling the liquid nitrogen flow, and the injection joint is injected into the cavity through the contrast agent connected with the inner cavity of the balloon and injects the contrast agent.
The invention has the advantages that the guiding insertion of the cryoablation system is improved through the guide wire, and the cryoablation guided by the balloon catheter and the stent catheter forms a stable channel on the inner side of the balloon due to the support of the stent component, so that the vascular pipeline is prevented from being completely sealed due to the expansion and compression of the balloon, and the vascular embolism is avoided. Meanwhile, the liquid nitrogen can be continuously input under the condition of not interrupting blood flow, so that the blood vessel keeps continuous cryoablation, the repeated circulating extraction and injection of the liquid nitrogen due to temperature rise and cryoablation failure of the liquid nitrogen are avoided, and the consequences of far-end severe ischemia and the like caused by target blood vessel occlusion in the operation are avoided.
Drawings
Fig. 1 is a schematic structural diagram of a balloon catheter of an uninterrupted blood flow cryoablation system according to the present invention.
Fig. 2 is a schematic structural view of a balloon catheter balloon portion of an uninterrupted blood flow cryoablation system of the present invention.
Fig. 3 is a schematic structural diagram of a stent catheter of the cryoablation system without interrupting blood flow according to the present invention.
Fig. 4 is a schematic view of the expanded stent assembly in the stent catheter of the cryoablation system without interrupting blood flow according to the present invention.
Fig. 5 is a schematic structural view of the stent catheter of the cryoablation system without interrupting blood flow after the stent assembly is retracted into the sheath.
Fig. 6-14 are schematic flow charts of a cryoablation method performed by the non-interrupting blood flow cryoablation system according to the present invention.
Wherein: 1-special-shaped saccule, 2a and 2 b-saccule developing rings, 3-catheter, 4-injection joint, 5-handle, 6-push rod, 7a, 7b and 7 c-stent in the stent component, 8a,8b and 8 c-stent developing rings, 9-inner tube, 10-outer sheath tube, 11-push block, 12-stop switch, 13-sealing switch, 14-special-shaped guide hole and 15-guide wire.
Detailed Description
In order to make the present invention better understood, the technical solutions adopted by the present invention are further described below with reference to the accompanying drawings and examples.
Example 1
As shown in fig. 1, an embodiment of a balloon catheter of an uninterrupted blood flow cryoablation system according to the present invention is provided, wherein the balloon catheter includes a shaped balloon 1, two developing rings 2a and 2b are disposed in the shaped balloon 1, the developing rings 2a and 2b are used for identifying a balloon position during radiography, so that the developing ring 2a is disposed at a front portion of the shaped balloon, the developing ring 2b is disposed at a rear portion of the shaped balloon, three inner chambers, namely a liquid nitrogen injection chamber and an output chamber, and a contrast medium injection chamber are disposed inside the shaped balloon, the three inner chambers are connected to a catheter 3, the catheter 3 is respectively connected to an injection connector 4 and a handle 5, the injection connector 4 is used for injecting contrast medium, the injection connector 4 is connected to the contrast medium injection chamber of the shaped balloon 1 through the catheter 3, the handle 5 is used for controlling the injection and outflow of liquid nitrogen, the handle 5 is connected to the liquid nitrogen injection chamber and the output chamber of the shaped balloon 1 through the catheter 3, the liquid nitrogen injection cavity is communicated with the liquid nitrogen output cavity, so that liquid nitrogen can circulate in the special-shaped saccule.
As shown in fig. 2, the balloon is also provided with a shaped guide hole, when the balloon is in a folded state, a guide wire can penetrate through the shaped guide hole, and when the balloon is in an expanded state, blood can be guided to pass through the shaped guide hole, so that relative occlusion of an ablation target blood vessel is prevented.
In the above figures, it should be noted that the injection connector is provided with a switching valve, which is used for injecting contrast medium and avoiding blood backflow.
Example 2
As shown in fig. 3, the stent catheter of the uninterrupted blood flow cryoablation system according to the embodiment of the invention includes a push rod 6, a stent assembly 7 is disposed at the front end of the push rod 6, and at least one stent is disposed on the stent assembly 7, as shown in the figure, three stents, namely, stents 7a, 7b, and 7c, are disposed on the stent assembly, wherein the three stents are stacked in front of and behind each other, so as to increase a supporting effect, the more the number of the stents are, the more the supporting effect is achieved, and the inner irregular guide hole is prevented from being blocked by pressure after the balloon is expanded, so that blood flow is affected, and a developing ring 8 is mounted at the rear end of each stent, as shown in fig. 8a,8b, and 8c, and is mounted at the rear end of the stent for achieving development positioning of the stent and also achieving limiting when the stent is expanded. Still be equipped with inner tube 9 and outer sheath pipe 10 on the propelling movement pipe, inner tube 9 with bracket component 7 is connected, outer sheath pipe 10 is located the inner tube 9 and the bracket component 7 outside, still be equipped with propelling movement piece 11 and stop position switch 12 on the inner tube 9, propelling movement piece 11 promotes the inner tube 9 makes inner tube 9 promote bracket component 7.
As shown in fig. 4 and 5, the stent assembly 7 can automatically change from a forward extending state to a supporting state after extending out of the sheath tube 10 to support the shaped balloon 1, the stop switch 12 is used to keep the stent on the stent assembly 7 in the forward extending state or the supporting state, and the rear end of the push rod 6 is provided with a sealing switch 13 which is used to seal the end of the lumen to avoid blood backflow.
The tip of the guide wire is of a pre-setting structure, so that the guide wire can conveniently enter the left pulmonary artery or the right pulmonary artery in the insertion process.
In the above figures, it should be noted that the stents 7a, 7b, 7c are made of nitinol, and are shaped by heat treatment to realize free distraction during operation, a stop switch on the inner tube of the stent catheter is provided with a screwing device for keeping the stent in a supporting or forward extending state continuously effective, the inner tube of the stent catheter is provided with a color ring mark for identifying the color ring position to judge whether the stent component is fully retracted into the outer sheath during pushing the outer sheath, the pushing rod of the stent catheter is made of a polymer material with certain rigidity and flexibility to make the stent catheter smoothly bend and realize the function of pushing the stent component, a sealing switch of the stent catheter is provided with a silica gel cushion for screwing the sealing switch after being inserted to a focus position, and the inner silica gel cushion can realize the sealing of the tail end of the catheter lumen, avoid the blood backward flow, the inner tube rear end outside of support pipe be equipped with position indication point, be used for discerning whether the bracket component is fully retrieved or is released.
Example 3
The following describes how to use the blood flow uninterrupted cryoablation system to perform cryoablation in the present invention with reference to the accompanying drawings and embodiments 1 and 2.
In this embodiment, the method comprises the following steps:
s1, as shown in fig. 6, inserting the guide wire 15 and delivering it to the left pulmonary artery;
s2, mounting the injector filled with the contrast medium on the injection joint 4 at the tail end of the balloon catheter, opening the switch valve, injecting the contrast medium, exhausting the air in the inner cavity of the catheter 3 in vitro, and closing the switch valve on the injection joint 4;
s3, as shown in fig. 7, the tail end of the guide wire 15 passes through the special-shaped guide hole 14 on the balloon 1, the balloon catheter is guided to enter the lesion position, and contrast agent can be injected in the guiding process to identify the state of the lesion position;
s4, as shown in fig. 8 and 9, opening the sealing switch 13 at the tail of the stent catheter, inserting the tail end of the guide wire 15 into the guide wire hole of the stent catheter, and closing the sealing switch 13 after guiding the stent catheter to pass through the balloon guiding hole to the lesion;
s5, as shown in fig. 10, after determining that the stent assembly 7 has entered the covering position of the balloon 1 by radiography, pushing the stent assembly 7 out of the outer sheath 10 by pushing the inner tube of the tube, pulling the push rod 6 back to a state where the stent assembly 7 is fully supported, and screwing the stop switch 12 to fix the push rod 6;
s6, as shown in fig. 11, injecting liquid nitrogen into the balloon 1 continuously through the handle 5, and expanding the balloon 1 to perform cryoablation on the lesion;
s7, as shown in fig. 12, after the ablation is completed, evacuating the liquid nitrogen in the balloon 1;
s8, as shown in fig. 13, turning on the stop switch 12, pushing the push-pull rod 6, extending the bracket assembly 7 fully, and then screwing the stop switch 12 to fix the push-pull rod 6;
s9, pushing the outer sheath tube 10, identifying whether the stent component 7 is fully retracted into the outer sheath tube 10 according to the mark point on the inner tube 9, and after the retraction is finished, taking out the guide wire 15 and the stent catheter together, and then taking out the balloon catheter.
The front end of the balloon catheter is provided with the special-shaped balloon and the front developing ring and the rear developing ring, so that the position of the balloon can be identified in radiography; the inner cavity of the balloon is connected with the handle through a catheter to realize internal communication, and the handle can be controlled to inject liquid nitrogen or output liquid nitrogen in an operation; the tail end of the catheter is connected with an injection joint, so that the injection of the contrast agent can be realized.
The multi-section telescopic bracket guide pipe is internally provided with a push rod, the front end of the push rod is provided with a plurality of brackets, the front end of the push rod is fixedly connected with the front end of the first bracket, meanwhile, the push rod on the inner side of the brackets is provided with a plurality of developing rings, and the tail end of the push rod is provided with a sealing switch; an inner tube outside the push rod is fixedly connected with the rear end of the last support so as to realize the front and back extension and contraction of the support, and the tail end of the inner tube is provided with a stop switch; the tail end of the outer sheath tube on the outer side of the balloon catheter is provided with a pushing block.
The tip of the guide wire is pre-shaped, so that the guide wire can be conveniently guided into a target blood vessel, such as a left pulmonary artery or a right pulmonary artery, in the insertion process.
The guiding insertion of the cryoablation system is improved through the scheme, the cryoablation under the continuous balloon guiding can be realized under the condition of not interrupting blood flow, and the consequences of far-end severe ischemia and the like caused by target vessel occlusion in the operation are avoided.
The above-mentioned embodiments only represent the preferred embodiments of the present invention, the emphasis is placed on the cryoablation system and the cryoablation method, and the matched parts are only exemplary, and the description thereof is specific and detailed, and is not intended to limit the scope of the present invention. It should be noted that, for those skilled in the art, various changes, modifications and substitutions can be made without departing from the spirit of the present invention, and these are all within the scope of the present invention. Therefore, the protection scope of the present patent shall be subject to the appended claims.
Claims (10)
1. A cryoablation system without interrupting blood flow is characterized by comprising a balloon catheter, a stent catheter and a guide wire, wherein the balloon catheter and the stent catheter are connected through the guide wire;
the balloon catheter comprises a special-shaped balloon, a catheter, an injection joint and a handle which are sequentially connected, a special-shaped guide hole for connecting with a guide wire is arranged on the special-shaped balloon, a developing ring is respectively arranged at the front and the back of the inside of the special-shaped balloon, the special-shaped balloon is internally divided into three inner cavities which are respectively connected with the injection joint and the handle through the catheter, the two inner cavities connected with the handle are respectively an injection cavity and an output cavity of liquid nitrogen, and the inner cavity connected with the injection joint is a contrast agent injection cavity;
the bracket guide tube comprises a push rod with a guide wire cavity inside, the push rod comprises a bracket component, an inner tube, an outer sheath tube and a sealing switch, the bracket component is positioned at the front end of the push rod and is provided with a developing ring, the sealing switch is arranged at the rear end of the push rod, the inner tube is connected with the bracket component, the outer sheath tube is arranged on the outer sides of the inner tube and the bracket component, and a push block and a stop switch are arranged at the other end of the inner tube;
the guide wire comprises a preformed structure, and the preformed structure is positioned at the front end of the guide wire.
2. The system of claim 1, wherein the injection connector of the balloon catheter is provided with a valve for injecting contrast medium and preventing blood backflow.
3. The system of claim 1, wherein the holder assembly includes a plurality of holders secured one on top of the other, the developer ring being mounted to an inner rear end of each holder.
4. The system of claim 3, wherein the stent is a nickel titanium alloy and is shaped by heat treatment.
5. The system of claim 1, wherein the stop switch on the inner tube of the stent catheter is provided with a tightening means for maintaining the stent in a sustained, supported or forwardly extended position.
6. The system of claim 5, wherein the inner tube of the stent catheter is provided with colored ring markings for identifying the position of the colored ring during advancement of the outer sheath to determine whether the stent assembly is sufficiently retracted within the outer sheath.
7. The system of claim 6, wherein the pushing rod of the stent catheter is made of a rigid and flexible polymer material.
8. The system of claim 1, wherein a silicone cushion is provided in the sealing switch of the stent catheter for sealing the distal end of the catheter lumen to prevent blood backflow.
9. The system of claim 1, wherein a position indicator is provided outside the rear end of the inner tube of the stent catheter to identify whether the stent assembly is fully retracted or released.
10. A cryoablation method using the system of claims 1-9 without interrupting blood flow, comprising the steps of:
s1, guiding a stent catheter into a balloon catheter through a guide wire, wherein a stent component is positioned at a special-shaped balloon;
s2, a push rod on the stent catheter is pushed, the stent component is pushed by an inner tube of the push rod and is changed from a forward extending state to a supporting state, so that a special-shaped balloon of the balloon catheter is deformed, a stable channel is formed through a stop switch, and the balloon is prevented from expanding;
s3, the liquid nitrogen is repeatedly and circularly pumped out and injected into the injection cavity and the output cavity of the liquid nitrogen through the handle continuity of the balloon catheter, the handle is connected with the balloon liquid nitrogen injection cavity and the output cavity of the balloon catheter through the catheter, the balloon body volume and the continuous cryoablation on the vascular wall are controlled by controlling the liquid nitrogen flow, and the injection joint is injected into the cavity through the contrast agent connected with the inner cavity of the balloon and injects the contrast agent.
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| CN116236237A (en) * | 2022-12-21 | 2023-06-09 | 南京思脉德医疗科技有限公司 | Foramen ovale plugging device and plugging method |
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| CN115153814A (en) * | 2022-06-23 | 2022-10-11 | 上海玮琅医疗科技有限公司 | Bracket type radio frequency ablation catheter |
| CN116236237A (en) * | 2022-12-21 | 2023-06-09 | 南京思脉德医疗科技有限公司 | Foramen ovale plugging device and plugging method |
| CN116236237B (en) * | 2022-12-21 | 2024-01-26 | 南京思脉德医疗科技有限公司 | Foramen ovale plugging device and plugging method |
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