CN111503978A - Device for freezing and unfreezing process of biological pharmaceutical material - Google Patents
Device for freezing and unfreezing process of biological pharmaceutical material Download PDFInfo
- Publication number
- CN111503978A CN111503978A CN202010342053.7A CN202010342053A CN111503978A CN 111503978 A CN111503978 A CN 111503978A CN 202010342053 A CN202010342053 A CN 202010342053A CN 111503978 A CN111503978 A CN 111503978A
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- China
- Prior art keywords
- screw rod
- spiral
- freezing
- driver
- partition plate
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Classifications
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- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F25—REFRIGERATION OR COOLING; COMBINED HEATING AND REFRIGERATION SYSTEMS; HEAT PUMP SYSTEMS; MANUFACTURE OR STORAGE OF ICE; LIQUEFACTION SOLIDIFICATION OF GASES
- F25D—REFRIGERATORS; COLD ROOMS; ICE-BOXES; COOLING OR FREEZING APPARATUS NOT OTHERWISE PROVIDED FOR
- F25D23/00—General constructional features
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- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F25—REFRIGERATION OR COOLING; COMBINED HEATING AND REFRIGERATION SYSTEMS; HEAT PUMP SYSTEMS; MANUFACTURE OR STORAGE OF ICE; LIQUEFACTION SOLIDIFICATION OF GASES
- F25D—REFRIGERATORS; COLD ROOMS; ICE-BOXES; COOLING OR FREEZING APPARATUS NOT OTHERWISE PROVIDED FOR
- F25D23/00—General constructional features
- F25D23/006—General constructional features for mounting refrigerating machinery components
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- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F25—REFRIGERATION OR COOLING; COMBINED HEATING AND REFRIGERATION SYSTEMS; HEAT PUMP SYSTEMS; MANUFACTURE OR STORAGE OF ICE; LIQUEFACTION SOLIDIFICATION OF GASES
- F25D—REFRIGERATORS; COLD ROOMS; ICE-BOXES; COOLING OR FREEZING APPARATUS NOT OTHERWISE PROVIDED FOR
- F25D23/00—General constructional features
- F25D23/12—Arrangements of compartments additional to cooling compartments; Combinations of refrigerators with other equipment, e.g. stove
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- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F25—REFRIGERATION OR COOLING; COMBINED HEATING AND REFRIGERATION SYSTEMS; HEAT PUMP SYSTEMS; MANUFACTURE OR STORAGE OF ICE; LIQUEFACTION SOLIDIFICATION OF GASES
- F25D—REFRIGERATORS; COLD ROOMS; ICE-BOXES; COOLING OR FREEZING APPARATUS NOT OTHERWISE PROVIDED FOR
- F25D29/00—Arrangement or mounting of control or safety devices
- F25D29/005—Mounting of control devices
Abstract
The invention relates to a device for freezing and unfreezing a biological pharmaceutical material, and belongs to the technical field of biological engineering pharmaceutical equipment. Comprises a clapboard, a driver, a fixed seat, a spiral screw rod and a spiral sleeve; a screw rod is arranged between the driver and the fixed seat; the spiral screw rod is sleeved with two spiral sleeves which do not rotate, but are relatively close to or separated from each other along with the rotation of the spiral screw rod; the two spiral sleeves are respectively provided with a clapboard with corresponding plate surface; the partition plate can realize relative movement and heat transfer. The invention adopts the driver to drive the bidirectional screw rod to drive the partition plate to move, the partition plate which moves relatively is more convenient to fix the biopharmaceutical material, the temperature of the whole partition plate is ensured to be uniform, and the problems of non-uniform temperature treatment and non-uniformity of the biopharmaceutical material in the freezing and unfreezing processes of the biopharmaceutical material in the same batch due to different specifications and different environments of the biopharmaceutical material are avoided under specific conditions.
Description
Technical Field
The invention relates to a device for freezing and unfreezing a biological pharmaceutical material, and belongs to the technical field of biological engineering pharmaceutical equipment.
Background
At present, most of domestic biopharmaceutical companies and scientific research institutions adopt traditional low-temperature refrigerators and barrel-type freeze-thaw systems to freeze and thaw biopharmaceutical materials. The barrel-shaped container or the regular container filled with the biopharmaceutical materials is put into a low-temperature refrigerator for freezing, the low-temperature refrigerator freezes by obtaining low-temperature air by accelerating the heat exchange between the air and a refrigerant in the refrigerator, and the aim of quickly freezing a working area is fulfilled by a low-temperature air forced convection blowing mode; or the biological pharmaceutical material is directly filled into a barrel type heat exchanger for freezing or thawing or mixing, the barrel type freeze thawing system is characterized in that a heat exchanger (a pipe type or a spiral pipe type or a plate type) is arranged in a barrel type container, and a heat exchange medium (a refrigerant or a heat conduction medium) is introduced into the heat exchanger to perform wall-dividing type heat exchange with the biological pharmaceutical material in the container so as to achieve the purpose of quick freezing or thawing. However, the low-temperature refrigerator or barrel type freezing and thawing system structure used at present has the following disadvantages: 1. due to the structural limitation of a freezing working space and the limitation of an air freezing and thawing working principle, the environmental temperature difference at different spatial positions in the working space is serious; different sub-packaging materials of the same batch of materials are in different freezing and thawing states in the freezing and thawing processes due to different freezing working space positions and different peripheral temperatures of the different sub-packaging materials of the same batch of materials in the freezing and thawing processes, so that the whole freezing and thawing processes are uncontrollable; 2. in the existing freezing and unfreezing processes, a freezing working space is fixed and unchanged, and the environmental temperature difference at different spatial positions in the working space is serious; with the change of the quantity of the biopharmaceutical material, the relationship between the phase transition temperature of the biopharmaceutical material and the change of the ambient temperature cannot be accurately determined, so that the process amplification control cannot be carried out; 3. the relation between the phase change temperature of the biopharmaceutical material and the temperature change of the surrounding environment cannot be accurately determined, the process record of a temperature curve is avoided, and the quality of a product cannot be ensured; 4. the existing freezing and thawing equipment is not easy to disinfect and clean, and has the risk of microbial pollution; 5. because different sub-packaging materials of the same batch of materials are in different freezing and thawing states in the freezing and thawing processes, the whole freezing and thawing processes are not uniformly carried out, and the whole synchronous processing cannot be ensured in the processing process of the biological pharmaceutical materials, the condition of non-uniform quality of the biological pharmaceutical materials of the same batch is caused, the quality evaluation is influenced, and the quality guarantee period of the whole effective activity is shorter. 6. At present, the price of equipment imported from abroad is expensive, and most of the biopharmaceutical companies cannot bear the price.
Disclosure of Invention
The invention aims to solve the technical problems of asynchronous and uneven temperature treatment in the freezing and thawing processes of the conventional biopharmaceutical material.
In order to solve the above problems, the present invention provides a device for freezing and thawing biopharmaceutical materials, comprising a partition plate, a driver, a fixed seat, a screw rod and a screw sleeve; a screw rod is arranged between the driver and the fixed seat; the spiral screw rod is sleeved with two spiral sleeves which do not rotate, but are relatively close to or separated from each other along with the rotation of the spiral screw rod; the two spiral sleeves are respectively provided with a partition plate with a plate surface vertical to the spiral screw rod and a corresponding plate surface; one ends of the two partition plates, which are far away from the spiral sleeve, are movably connected; the partition board is in a hollow plate shape, and a heat conducting medium is arranged in the partition board.
Preferably, two guide brackets are respectively arranged on one side of each of the two partition plates, which is far away from the spiral sleeve, and a guide rod is arranged between the guide brackets arranged on the corresponding partition plates and is parallel to the spiral screw rod; two guide supports arranged on one partition plate are arranged on two sides of the spiral screw rod.
Preferably, the number of the drivers and the number of the fixing seats are respectively one, and the drivers and the fixing seats are respectively arranged on the outer sides of the two partition plates.
Preferably, the number of the drivers is one, and the number of the fixing seats is two; the driver is set as a double-output-shaft driver, the driver is arranged between the two partition plates, and the two fixing seats are respectively arranged on the outer sides of the two partition plates.
Preferably, the partition plate surface corresponding to the partition plate is made of a metal material with uniform heat conduction.
Preferably, a temperature probe is arranged on the corresponding partition plate surface of the partition plate.
The invention adopts the technical scheme that the spiral screw rod drives the partition plate through the partition plate spiral sleeve, and the guide rod guides the partition plate to realize the relative movement of clamping and opening the partition plate. The invention adopts the driver to drive the bidirectional screw rod to drive the partition plate to move, the partition plate which moves relatively is more convenient to fix the biopharmaceutical materials, and the structure ensures that the biopharmaceutical materials can avoid the problem of uneven temperature treatment in the freezing and thawing processes caused by different specifications and environments of the biopharmaceutical materials in the same batch under specific conditions.
Compared with the prior art, the invention has the following beneficial effects:
1. bidirectional spiral clamping structure can guarantee that the bio-pharmaceuticals material passes through regular container and heat transfer baffle even contact, has avoided low temperature refrigerator and bucket formula freeze thawing system to transmit inhomogeneous problem because of the structural constraint, realizes more efficient heat transfer, and the shaping is more pleasing to the eye after bio-pharmaceuticals material processing, protects the effective activity of bio-pharmaceuticals material.
2. The driver, the screw rod and the guide rod are easy to arrange, and various installation modes can be realized; the device is more easily compact in design, reducing the overall size of similar devices.
3. In the device structure of the invention, the partition boards can be separated, and the aseptic treatment and the disinfection treatment can be realized more easily. The partition plate and the movement mechanism can also adopt an isolated closed design, so that the problem of microbial pollution is avoided.
Drawings
FIG. 1 is a schematic structural diagram I of an apparatus for freezing and thawing biopharmaceutical materials according to the present invention.
Fig. 2 is a schematic structural diagram II of an apparatus for freezing and thawing biopharmaceutical materials according to the present invention.
Fig. 3 is a schematic motion diagram of a bidirectional bolt fixing mechanism of the device for freezing and thawing the biopharmaceutical material provided by the invention.
Fig. 4 is a top view of the bi-directional screw mounting mechanism assembly of an apparatus for use in a process for freezing and thawing a biopharmaceutical material according to the present invention.
Reference numerals: 1. the guide rod 2, the guide bracket 3, the partition plate 4, the spiral screw rod 5, the fixed seat 6 and the driver;
Detailed Description
In order to make the invention more comprehensible, preferred embodiments are described in detail below with reference to the accompanying drawings:
as shown in fig. 1 to 4, the present invention provides an apparatus for freezing and thawing of biopharmaceutical materials, comprising a spacer 3, a driver 6, a fixed seat 5, a screw rod 4 and a screw sleeve; a screw rod 4 is arranged between the driver 6 and the fixed seat 5; the spiral screw rod 4 is sleeved with two spiral sleeves which do not rotate, but are relatively close to or separated from each other along with the rotation of the spiral screw rod; the two spiral sleeves are respectively provided with a partition plate 3 with the plate surface vertical to the spiral screw rod 4 and the plate surface corresponding to the partition plate; one ends of the two partition plates 3 far away from the spiral sleeve are movably connected; the partition 3 is provided in the form of a hollow plate, and a heat conducting medium is provided inside the partition. Two guide brackets 2 are respectively arranged on one side of each partition plate 3 far away from the spiral sleeve, a guide rod 1 is arranged between the guide brackets 2 arranged on the corresponding partition plates 3, and the guide rods 1 are parallel to the spiral screw rod 4; two guide brackets 2 arranged on one partition plate 3 are arranged on two sides of a spiral screw rod 4. The number of the driver 6 and the fixed seat 5 can be one, and the driver 6 and the fixed seat 5 are respectively arranged on the outer sides of the two partition plates 3. The number of the drivers 6 can also be set to be one, and the number of the fixed seats 5 is set to be two; the driver 6 is set as a double-output-shaft driver, the driver 6 is arranged between the two partition plates 3, and the two fixing seats 5 are respectively arranged on the outer sides of the two partition plates 3. The corresponding baffle surface of the baffle is made of metal material with uniform heat conduction. The surface of the clapboard corresponding to the clapboard is provided with a temperature probe.
The traditional low-temperature refrigerator freezing and storing mode is that air is forcibly supplied in a cavity and exchanges heat with a refrigerant to obtain low-temperature air, so that the aim of quickly freezing and storing the biopharmaceutical material is fulfilled. Adopt traditional this kind of equipment because of receiving the structure restriction, there is not synchronous, inhomogeneous technical problem of temperature treatment in the freezing of biological pharmaceutical material, the thawing process. The temperature can not be controlled uniformly, the breeding and pollution of microorganisms can not be avoided, and the quality of the biological pharmaceutical material can not be ensured. Even if a barrel-type freeze thawing mode is adopted, the quality of the final biopharmaceutical material cannot be ensured due to uneven distribution of the biopharmaceutical material in the barrel-type structure.
The bidirectional spiral fixing mechanism effectively solves the problem of fixing the biopharmaceutical material, and more importantly, realizes the process treatment of quick freezing and thawing of the biopharmaceutical material. The invention adopts the driver to drive the bidirectional screw rod so as to drive the partition plate to move, the partition plate which moves relatively is more convenient to fix the biopharmaceutical material, and the whole partition plate can ensure uniform temperature. The structure can avoid the problems of non-uniform temperature treatment and non-uniform temperature treatment in the freezing and thawing processes of the biopharmaceutical materials in the same batch due to different specifications and different environments of the biopharmaceutical materials under specific conditions.
While the invention has been described with respect to a preferred embodiment, it will be understood by those skilled in the art that various changes in form and details may be made therein without departing from the spirit and scope of the invention. Those skilled in the art can make various changes, modifications and equivalent arrangements, which are equivalent to the embodiments of the present invention, without departing from the spirit and scope of the present invention, and which may be made by utilizing the techniques disclosed above; meanwhile, any changes, modifications and variations of the above-described embodiments, which are equivalent to those of the technical spirit of the present invention, are within the scope of the technical solution of the present invention.
Claims (6)
1. An apparatus for freezing and thawing biopharmaceutical materials, comprising: comprises a clapboard, a driver, a fixed seat, a spiral screw rod and a spiral sleeve; a screw rod is arranged between the driver and the fixed seat; the spiral screw rod is sleeved with two spiral sleeves which do not rotate, but are relatively close to or separated from each other along with the rotation of the spiral screw rod; the two spiral sleeves are respectively provided with a partition plate with a plate surface vertical to the spiral screw rod and a corresponding plate surface; one ends of the two partition plates, which are far away from the spiral sleeve, are movably connected; the partition board is in a hollow plate shape, and a heat conducting medium is arranged in the partition board.
2. The apparatus of claim 1 for use in a biopharmaceutical material freezing and thawing process, wherein: two guide brackets are respectively arranged on one side of each of the two partition plates, which is far away from the spiral sleeve, and a guide rod is arranged between the guide brackets arranged on the corresponding partition plates and is parallel to the spiral screw rod; two guide supports arranged on one partition plate are arranged on two sides of the spiral screw rod.
3. The apparatus of claim 1 for use in a biopharmaceutical material freezing and thawing process, wherein: the driver and the fixing seat are respectively arranged at the outer sides of the two partition plates.
4. The apparatus of claim 1 for use in a biopharmaceutical material freezing and thawing process, wherein: the number of the drivers is one, and the number of the fixing seats is two; the driver is set as a double-output-shaft driver, the driver is arranged between the two partition plates, and the two fixing seats are respectively arranged on the outer sides of the two partition plates.
5. The apparatus of claim 1 for use in a biopharmaceutical material freezing and thawing process, wherein: the corresponding baffle surface of the baffle is made of metal material with uniform heat conduction.
6. The apparatus of claim 1 for use in a biopharmaceutical material freezing and thawing process, wherein: and a temperature probe is arranged on the partition plate surface corresponding to the partition plate.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202010342053.7A CN111503978A (en) | 2020-04-27 | 2020-04-27 | Device for freezing and unfreezing process of biological pharmaceutical material |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202010342053.7A CN111503978A (en) | 2020-04-27 | 2020-04-27 | Device for freezing and unfreezing process of biological pharmaceutical material |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN111503978A true CN111503978A (en) | 2020-08-07 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202010342053.7A Pending CN111503978A (en) | 2020-04-27 | 2020-04-27 | Device for freezing and unfreezing process of biological pharmaceutical material |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN111503978A (en) |
Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20040134203A1 (en) * | 2001-05-22 | 2004-07-15 | Integrated Biosystems, Inc. | Systems and methods for freezing, storing and thawing biopharmaceutical material |
| CN1582111A (en) * | 2001-11-01 | 2005-02-16 | 综合生物系统公司 | Systems and methods for freezing, storing and thawing biopharmaceutical material |
| US20050180998A1 (en) * | 2001-05-22 | 2005-08-18 | Integrated Biosystems, Inc. | Systems and methods for freezing, mixing and thawing biopharmaceutical material |
| CN1685186A (en) * | 2002-09-23 | 2005-10-19 | 综合生物系统公司 | Systems and methods for freezing, mixing and thawing biopharmaceutical material |
| US20070084222A1 (en) * | 2001-11-01 | 2007-04-19 | Integrated Biosystems, Inc. | Systems and methods for freezing, storing, transporting, and thawing biopharmacuetical material |
| CN105922724A (en) * | 2016-06-22 | 2016-09-07 | 桐乡市凤鸣制罐厂 | Screen drawing mechanism for screen printing |
| CN110274418A (en) * | 2018-03-16 | 2019-09-24 | 江苏悉典生物医药设备有限公司 | A kind of freeze thawing machine inside cold plate arrangement apparatus |
| CN210089194U (en) * | 2019-05-06 | 2020-02-18 | 常熟市中药制药机械有限责任公司 | Condenser support |
-
2020
- 2020-04-27 CN CN202010342053.7A patent/CN111503978A/en active Pending
Patent Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20040134203A1 (en) * | 2001-05-22 | 2004-07-15 | Integrated Biosystems, Inc. | Systems and methods for freezing, storing and thawing biopharmaceutical material |
| US20050180998A1 (en) * | 2001-05-22 | 2005-08-18 | Integrated Biosystems, Inc. | Systems and methods for freezing, mixing and thawing biopharmaceutical material |
| CN1582111A (en) * | 2001-11-01 | 2005-02-16 | 综合生物系统公司 | Systems and methods for freezing, storing and thawing biopharmaceutical material |
| US20070084222A1 (en) * | 2001-11-01 | 2007-04-19 | Integrated Biosystems, Inc. | Systems and methods for freezing, storing, transporting, and thawing biopharmacuetical material |
| CN1685186A (en) * | 2002-09-23 | 2005-10-19 | 综合生物系统公司 | Systems and methods for freezing, mixing and thawing biopharmaceutical material |
| CN105922724A (en) * | 2016-06-22 | 2016-09-07 | 桐乡市凤鸣制罐厂 | Screen drawing mechanism for screen printing |
| CN110274418A (en) * | 2018-03-16 | 2019-09-24 | 江苏悉典生物医药设备有限公司 | A kind of freeze thawing machine inside cold plate arrangement apparatus |
| CN210089194U (en) * | 2019-05-06 | 2020-02-18 | 常熟市中药制药机械有限责任公司 | Condenser support |
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Application publication date: 20200807 |