CN111494089A

CN111494089A - Abdominal cavity thermal perfusion chemotherapy treatment system

Info

Publication number: CN111494089A
Application number: CN202010320109.9A
Authority: CN
Inventors: 屈治国; 田地; 蒲嘉麒; 闫融; 朱琨; 杨谨
Original assignee: Xian Jiaotong University
Current assignee: Xian Jiaotong University
Priority date: 2020-04-22
Filing date: 2020-04-22
Publication date: 2020-08-07

Abstract

The present disclosure discloses an abdominal cavity thermal perfusion chemotherapy treatment system, comprising: an input subsystem and an output subsystem; the input subsystem comprises a medicine storage bag, a first input pump, an input conduit, a second input pump and an abdominal cavity perfusion end, wherein the medicine storage bag is connected to the first input pump, the first input pump is connected to the abdominal cavity perfusion end through the input conduit, and one end of the second input pump is connected to the input conduit; the output subsystem comprises an abdominal cavity drainage end, an output conduit, an output pump, a purification unit and a collection bag, wherein the abdominal cavity drainage end is connected to the output pump through the output conduit, the output pump is connected to the purification unit, the purification unit is used for purifying perfusion liquid flowing out of an abdominal cavity, a first output end of the purification unit is connected to the collection bag, and a second output end of the purification unit is connected to the other end of the second input pump.

Description

Abdominal cavity thermal perfusion chemotherapy treatment system

Technical Field

The present disclosure relates to a thermal perfusion chemotherapy system for abdominal cavity, and more particularly to a thermal perfusion chemotherapy system for abdominal cavity.

Background

The chemotherapy (HIPEC) for abdominal cavity heat perfusion is a new type of therapy for abdominal cavity transferred cancer, integrates regional chemotherapy, thermotherapy and mechanical lavage of the abdominal cavity by large-capacity liquid, fills the constant-temperature perfusion liquid containing chemotherapy drugs into the abdominal cavity and maintains circulation for a certain time, achieves the effect of removing and killing free cancer cells and tiny cancer focuses in the abdominal cavity, and is the most reasonable and effective auxiliary measure for matching with the full peritoneal denudation. The principle mainly comprises: the chemotherapy medicine with low peritoneal absorption rate is directly poured into the abdominal cavity, the concentration of other visceral organs is low, and the toxic and side effects of the abdominal cavity heat pouring chemotherapy on the whole body are low; at the same time, cancer cells are unstable to heat and burst in water at 43 degrees celsius.

Before treatment, a drainage tube is placed through an operation or puncture of the abdominal cavity to establish liquid circulation between the thermal perfusion chemotherapy instrument and the abdominal cavity. Due to the adhesion effect of tumor cells, the generation of blood clots, necrotic cells in the abdominal cavity of a patient, tissue exfoliation, and the wrapping of the omentum and intestinal canal, tube blockage often occurs in the circulation pipeline, which seriously affects the treatment process and effect. At present, the main solution to the tube blockage phenomenon is to cut off the omentum majus and place lubricant in the abdominal cavity during the operation, change the shape of the in-out catheter and exchange or change the insertion position of the inlet and outlet catheter during the treatment process, and the generated effect is uncertain and may cause secondary damage to the patient.

Disclosure of Invention

Aiming at the defects in the prior art, the disclosed object is to provide an abdominal cavity thermal perfusion chemotherapy treatment system, which utilizes a separator to settle and remove components which are easy to cause tube blockage, such as cell mass, tissue, blood clot and the like in perfusate, solves the tube blockage problem of small and medium free impurities in the abdominal cavity, and can ensure the normal and stable operation of the treatment system.

In order to achieve the above purpose, the present disclosure provides the following technical solutions:

a system for thermal intraperitoneal perfusion chemotherapy treatment, comprising: an input subsystem and an output subsystem;

wherein the input subsystem comprises a medicine storage bag, a first input pump, an input catheter, a second input pump and an abdominal cavity perfusion end,

the medicine storage bag is connected to a first input pump,

the first input pump is connected to the peritoneal irrigation end through the input conduit,

one end of the second input pump is connected to the input conduit;

the output subsystem comprises an abdominal cavity drainage end, an output pump, an output catheter, a purification unit and a collection bag,

the abdominal cavity drainage end is connected to the output pump through the output conduit,

the output pump is connected to the purification unit,

the purification unit is used for purifying the perfusate flowing out of the abdominal cavity, a first output end of the purification unit is connected to the collection bag, and a second output end of the purification unit is connected to the other end of the second input pump.

Preferably, the purification unit separates impurities in the perfusion fluid flowing out of the drainage end of the abdominal cavity by using insulation dielectrophoresis of an alternating-current or direct-current electric field.

Preferably, the purification unit employs a separator, the separator comprising: the device comprises a shell, a first electrode plate, a second electrode plate, an insulator and a sewage draining channel; the first electrode plate and the second electrode plate are respectively arranged on the upper inner surface and the lower inner surface of the shell, the insulator is distributed in a relative flow passage of the first electrode plate and the second electrode plate, and the sewage discharge channel is arranged at one end, close to the collecting bag, of the shell.

Preferably, the sewage draining channel comprises a first sewage draining channel and a second sewage draining channel, the input end of the first sewage draining channel is tightly attached to the first electrode plate, and the output end of the first sewage draining channel is connected to the collecting bag; the input end of the second sewage draining channel is tightly attached to the second electrode plate, and the output end of the second sewage draining channel is connected to the collecting bag.

Preferably, the first sewage draining channel and the first electrode plate form an included angle of 15-30 degrees, and the second sewage draining channel and the second electrode plate form an included angle of 15-30 degrees.

Preferably, the system further comprises a heating unit fixed to the input conduit for heating the perfusion fluid flowing through the input conduit.

Preferably, the heating unit adopts a heating film.

Preferably, the system further comprises a control and monitoring unit, wherein the control and monitoring unit is respectively connected with the purification unit and the heating unit and is used for monitoring the pressure of the perfusion fluid flowing into and out of the purification unit and monitoring the temperature of the heating unit;

and the number of the first and second groups,

the heating device is used for controlling the working frequency and power of the purification unit according to the pressure of the perfusion fluid flowing into and out of the purification unit and controlling the heating power of the heating unit according to the temperature of the heating unit.

Preferably, the control and monitoring unit comprises a pressure sensor, a temperature sensor and a single chip microcomputer.

Preferably, the first input pump, the second input pump and the output pump comprise any one of: peristaltic pumps, micro vacuum pumps and syringe pumps.

Compared with the prior art, the beneficial effect that this disclosure brought does:

1. the perfusate is purified to lead the components of cell block masses, tissues, blood clots and the like which are easy to cause tube blockage to be absorbed, thus solving the tube blockage problem of small and medium free impurities in the abdominal cavity and ensuring the normal and stable operation of a treatment system;

2. the perfusate is heated before entering the abdominal cavity, so that the temperature of the perfusate is prevented from being reduced due to heat dissipation, and the treatment effect is ensured;

3. the heating power of the heating unit and the working voltage and the working frequency of the purification unit can be adjusted in real time according to the working conditions, and the optimal purification effect is achieved.

Drawings

Fig. 1 is a schematic structural diagram of an abdominal cavity thermal perfusion chemotherapy treatment system according to an embodiment of the present disclosure;

fig. 2 is a schematic structural diagram of a separator provided in an embodiment of the present disclosure.

Detailed Description

Specific embodiments of the present disclosure will be described in detail below with reference to fig. 1 and 2. While specific embodiments of the disclosure are shown in the drawings, it should be understood that the disclosure may be embodied in various forms and should not be limited to the embodiments set forth herein. Rather, these embodiments are provided so that this disclosure will be thorough and complete, and will fully convey the scope of the disclosure to those skilled in the art.

It should be noted that certain terms are used throughout the description and claims to refer to particular components. As one skilled in the art will appreciate, various names may be used to refer to a component. This specification and claims do not intend to distinguish between components that differ in name but not function. In the following description and in the claims, the terms "include" and "comprise" are used in an open-ended fashion, and thus should be interpreted to mean "include, but not limited to. The description which follows is a preferred embodiment of the invention, but is made for the purpose of illustrating the general principles of the invention and not for the purpose of limiting the scope of the invention. The scope of the present disclosure is to be determined by the terms of the appended claims.

To facilitate an understanding of the embodiments of the present disclosure, the following detailed description is to be considered in conjunction with the accompanying drawings, and the drawings are not to be construed as limiting the embodiments of the present disclosure.

In one embodiment, as shown in fig. 1, a system for thermal intraperitoneal perfusion chemotherapy treatment comprises: an input subsystem and an output subsystem;

the medicine storage bag is connected to a first input pump,

one end of the second input pump is connected to the input conduit;

the output pump is connected to the purification unit,

This embodiment constitutes this disclosed complete technical scheme, and concrete theory of operation does: the perfusion liquid containing the chemotherapeutic drugs stored in the drug storage bag is pumped into the input conduit by the first input pump and then flows into the abdominal cavity through the abdominal cavity perfusion end, the perfusion liquid enters the output conduit through the abdominal cavity drainage end after acting on the abdominal cavity and is pumped into the purification unit by the output pump, after the purification treatment of the purification unit, the impurity particles such as cells, tissues, blood clots and the like falling off in the abdominal cavity are separated from the perfusion liquid and enter the collection bag, and the purified perfusion liquid is pumped into the input conduit by the second input pump and mixed with the perfusion liquid flowing out of the drug storage bag and flows into the abdominal cavity perfusion end.

This embodiment is through carrying out purification treatment to the perfusate of the abdominal cavity of flowing out, collects the impurity of separation, can overcome the problem that the circulating line that the particle impurity in the abdominal cavity caused blockked up to circulating line's unobstructed has been guaranteed.

In another embodiment, the purification unit separates impurities in the perfusion fluid flowing out of the drainage end of the abdominal cavity by means of insulated dielectrophoresis of an alternating current or direct current electric field.

In the embodiment, by utilizing the principle of an alternating-current electric field-based insulation dielectrophoresis technology in the dielectrophoresis technology, dispersed insulators are inserted into the separator, the first electrode plate and the second electrode plate generate an electric field after being electrified, and the electric field bypasses the insulators to be distributed on the periphery of the insulators to generate a high-gradient electric field due to the interference of the insulators, so that the insulation dielectrophoresis is caused. The electric polarization capability of the impurity particles such as cell aggregates, tissues, blood clots and the like contained in the perfusate is weaker than that of the perfusate, and the impurity particles are subjected to dielectrophoresis force in a high-gradient electric field and continuously move towards a low-gradient electric field and two polar plates, so that the aim of separating the impurity particles from the perfusate is fulfilled, and the separated impurity particles are discharged into a collecting bag through a sewage discharge channel, so that the problem of blockage of a circulating pipeline can be solved.

In another embodiment, as shown in FIG. 2, the purification unit employs a separator comprising: the device comprises a shell, a first electrode plate, a second electrode plate, an insulator and a sewage draining channel; the first electrode plate and the second electrode plate are respectively arranged on the upper inner surface and the lower inner surface of the shell, the insulator is distributed in the relative flow channel of the first electrode plate and the second electrode plate, and the sewage discharge channel is arranged at one end of the shell close to the collecting bag.

In this embodiment, the parts of the first electrode plate and the second electrode plate contacting the perfusion fluid are made of insulating materials such as insulating ceramics, and the electrifying part is positioned in the shell and can be selected from common metal electrodes.

It should be noted that the housing used in this embodiment is made of non-toxic insulating material, such as synthetic rubber, PVC plastic, etc.

In another embodiment, as shown in fig. 2, the trapway includes a first trapway having an input end that abuts the first electrode plate and an output end that is coupled to a collection bag; the input end of the second sewage draining channel is tightly attached to the second electrode plate, and the output end of the second sewage draining channel is connected to the collecting bag.

In the embodiment, the included angles between the first sewage draining channel and the second sewage draining channel and between the first electrode plate and the second sewage draining channel are set to be 15-30 degrees, so that the whole flow resistance of the flow channel is minimized and the flow of the main flow channel is maximized while the migration of the particulate impurities is realized under the dielectrophoretic force. If it is beyond this range, the flow resistance of the flow passage increases and the main flow passage flow rate decreases.

In another embodiment, the insulators are distributed in a cross shape.

In the embodiment, the insulator adopts a crossed distribution mode of front dense and back dense, front dense and back dense or random arrangement, and aims to increase dielectrophoresis force to promote rapid separation of impurities, reduce flow resistance of the perfusate and not influence treatment effect.

In another embodiment, the system further comprises a heating unit for heating the perfusion fluid output by the storage unit.

In the embodiment, the perfusion liquid containing the chemotherapeutic drugs is heated to the rated temperature (generally set to 42-43 ℃) by the heating unit and then is input into the abdominal cavity, and the perfusion liquid heated to the temperature range can kill tumor cells but does not damage normal cells, and meanwhile, the combination of the chemotherapeutic drugs and cancer cells can be promoted, so that the treatment effect is enhanced.

It will be appreciated that the heating unit may be heated using conventional heating means, and the present embodiment preferably uses a heating membrane to heat the perfusion fluid.

It should be noted that the purified perfusion fluid is pumped into the input conduit through the second input pump, and then enters the abdominal cavity perfusion end after being heated by the heating unit together with the perfusion fluid pumped in through the first input pump.

In another embodiment, the system further comprises a control and monitoring unit, which is connected to the purification unit and the heating unit, respectively, for monitoring the pressure of the perfusion fluid flowing into and out of the purification unit and monitoring the temperature of the heating unit;

and the number of the first and second groups,

and the heating device is used for controlling the working frequency and power of the purification unit according to the pressure of the perfusion fluid flowing into and out of the purification unit and controlling the heating power of the heating unit according to the temperature of the heating unit.

In the embodiment, the pressure sensor is arranged to monitor the pressure of the perfusate flowing into and out of the separator, when the pressure sensor monitors that the pressure difference between the inflow and the outflow is smaller than the rated pressure difference, the voltage and the frequency of the first electrode and the second electrode in the separator are adjusted through the singlechip, so that the dielectrophoresis separating force of the impurity particles is enhanced, the flow of the perfusate in the separator is stabilized, and the optimal adsorption effect of the impurity particles in the separator is achieved.

It should be noted that the adjustment amplitude of the electrode voltage and frequency is directly proportional to the difference between the measured differential pressure of the pressure sensor and the rated differential pressure, and the rated differential pressure is 110% -140% of the differential pressure of the perfusate flowing through the separator, and is specifically determined by the constitution of the patient.

In this embodiment, a temperature sensor is further provided to monitor the temperature of the perfusate to be flowed into the abdominal cavity, and when the temperature of the perfusate is lower than the rated temperature, the heating power of the heating unit is increased by the control of the single chip microcomputer; when the temperature of the perfusate is higher than the rated temperature, the heating power of the heating unit is reduced or the heating is stopped under the control of the single chip microcomputer.

In another embodiment, the first input pump, the second input pump, and the output pump comprise any one of: peristaltic pumps, micro vacuum pumps and syringe pumps.

The embodiment adopts peristaltic pump, micro vacuum pump or syringe pump to the perfusate pump cycle pump after will purifying to the abdominal cavity, because the peristaltic pump can the accurate flow of control perfusate, and mechanical pulse is little in the course of the work, and flow fluctuation is little, and the pressure fluctuation is little, can alleviate the uncomfortable sense of patient in the treatment process greatly, therefore this embodiment regards the peristaltic pump as preferred.

While the embodiments of the disclosure have been described above in connection with the drawings, the disclosure is not limited to the specific embodiments and applications described above, which are intended to be illustrative, instructive, and not restrictive. Those skilled in the art, having the benefit of this disclosure, may effect numerous modifications thereto and changes may be made without departing from the scope of the disclosure as set forth in the claims that follow.

Claims

1. A system for thermal intraperitoneal perfusion chemotherapy treatment, comprising: an input subsystem and an output subsystem;

the medicine storage bag is connected to a first input pump,

one end of the second input pump is connected to the input conduit;

the output subsystem comprises an abdominal cavity drainage end, an output catheter, an output pump, a purification unit and a collection bag,

the output pump is connected to the purification unit,

2. The system of claim 1, wherein the purification unit preferably separates impurities in the perfusion fluid exiting the drainage end of the abdominal cavity by insulated dielectrophoresis using an alternating or direct current electric field.

3. The system of claim 1, wherein the purification unit employs a separator comprising: the device comprises a shell, a first electrode plate, a second electrode plate, an insulator and a sewage draining channel; the first electrode plate and the second electrode plate are respectively arranged on the upper inner surface and the lower inner surface of the shell, the insulator is distributed in a relative flow passage of the first electrode plate and the second electrode plate, and the sewage discharge channel is arranged at one end, close to the collecting bag, of the shell.

4. The system of claim 3, wherein the trapway comprises a first trapway and a second trapway, the first trapway having an input end proximate the first electrode plate and an output end coupled to a collection bag; the input end of the second sewage draining channel is tightly attached to the second electrode plate, and the output end of the second sewage draining channel is connected to the collecting bag.

5. The system of claim 4, wherein the first trapway is angled at 15-30 ° from the first electrode plate and the second trapway is angled at 15-30 ° from the second electrode plate.

6. The system of claim 1, further comprising a heating unit located between the first input pump and the peritoneal irrigation end for heating the perfusion fluid flowing through the input conduit.

7. The system of claim 6, wherein the heating unit employs a heating film.

8. The system of claim 6, further comprising a control and monitoring unit connected to the purification unit and the heating unit, respectively, for monitoring the pressure of the perfusion fluid flowing into and out of the purification unit and monitoring the temperature of the heating unit;

and the number of the first and second groups,

9. The system of claim 7, wherein the control and monitoring unit comprises a pressure sensor, a temperature sensor, and a single chip microcomputer.

10. The system of claim 1, wherein the first input pump, second input pump, and output pump comprise any of: peristaltic pumps, micro vacuum pumps and syringe pumps.