CN111459105A - Pharmaceutic adjuvant automation line control system - Google Patents
Pharmaceutic adjuvant automation line control system Download PDFInfo
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- CN111459105A CN111459105A CN202010241687.3A CN202010241687A CN111459105A CN 111459105 A CN111459105 A CN 111459105A CN 202010241687 A CN202010241687 A CN 202010241687A CN 111459105 A CN111459105 A CN 111459105A
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- 239000000546 pharmaceutical excipient Substances 0.000 title claims abstract description 18
- 238000004519 manufacturing process Methods 0.000 claims abstract description 168
- 238000000034 method Methods 0.000 claims abstract description 26
- 238000012544 monitoring process Methods 0.000 claims abstract description 22
- 238000004458 analytical method Methods 0.000 claims abstract description 15
- 238000011958 production data acquisition Methods 0.000 claims abstract description 15
- 238000001514 detection method Methods 0.000 claims abstract description 11
- 238000007726 management method Methods 0.000 claims abstract description 9
- 239000000463 material Substances 0.000 claims description 21
- 230000002159 abnormal effect Effects 0.000 claims description 14
- 238000005516 engineering process Methods 0.000 claims description 7
- 238000004806 packaging method and process Methods 0.000 claims description 7
- 229940124531 pharmaceutical excipient Drugs 0.000 claims description 6
- 239000002994 raw material Substances 0.000 claims description 5
- 239000007788 liquid Substances 0.000 claims description 4
- 230000035484 reaction time Effects 0.000 claims description 4
- 238000012546 transfer Methods 0.000 claims description 4
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 3
- 230000005856 abnormality Effects 0.000 claims description 3
- 239000002253 acid Substances 0.000 claims description 3
- 238000011084 recovery Methods 0.000 claims description 3
- 238000012360 testing method Methods 0.000 claims description 3
- 238000012937 correction Methods 0.000 claims 1
- 239000003814 drug Substances 0.000 description 3
- 238000002360 preparation method Methods 0.000 description 3
- 238000010586 diagram Methods 0.000 description 2
- 238000009826 distribution Methods 0.000 description 2
- 238000003860 storage Methods 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 238000012384 transportation and delivery Methods 0.000 description 2
- 238000004090 dissolution Methods 0.000 description 1
- 239000002552 dosage form Substances 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 238000012856 packing Methods 0.000 description 1
- 230000001766 physiological effect Effects 0.000 description 1
- 238000013439 planning Methods 0.000 description 1
- 238000007639 printing Methods 0.000 description 1
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- G—PHYSICS
- G05—CONTROLLING; REGULATING
- G05B—CONTROL OR REGULATING SYSTEMS IN GENERAL; FUNCTIONAL ELEMENTS OF SUCH SYSTEMS; MONITORING OR TESTING ARRANGEMENTS FOR SUCH SYSTEMS OR ELEMENTS
- G05B19/00—Programme-control systems
- G05B19/02—Programme-control systems electric
- G05B19/418—Total factory control, i.e. centrally controlling a plurality of machines, e.g. direct or distributed numerical control [DNC], flexible manufacturing systems [FMS], integrated manufacturing systems [IMS] or computer integrated manufacturing [CIM]
- G05B19/41865—Total factory control, i.e. centrally controlling a plurality of machines, e.g. direct or distributed numerical control [DNC], flexible manufacturing systems [FMS], integrated manufacturing systems [IMS] or computer integrated manufacturing [CIM] characterised by job scheduling, process planning, material flow
-
- G—PHYSICS
- G05—CONTROLLING; REGULATING
- G05B—CONTROL OR REGULATING SYSTEMS IN GENERAL; FUNCTIONAL ELEMENTS OF SUCH SYSTEMS; MONITORING OR TESTING ARRANGEMENTS FOR SUCH SYSTEMS OR ELEMENTS
- G05B2219/00—Program-control systems
- G05B2219/30—Nc systems
- G05B2219/32—Operator till task planning
- G05B2219/32252—Scheduling production, machining, job shop
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P90/00—Enabling technologies with a potential contribution to greenhouse gas [GHG] emissions mitigation
- Y02P90/02—Total factory control, e.g. smart factories, flexible manufacturing systems [FMS] or integrated manufacturing systems [IMS]
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- Engineering & Computer Science (AREA)
- General Engineering & Computer Science (AREA)
- Manufacturing & Machinery (AREA)
- Quality & Reliability (AREA)
- Physics & Mathematics (AREA)
- General Physics & Mathematics (AREA)
- Automation & Control Theory (AREA)
- General Factory Administration (AREA)
Abstract
The invention discloses a pharmaceutic adjuvant automatic production line control system, which relates to the field of pharmaceutic adjuvant production and comprises production data acquisition and analysis, production equipment running state monitoring, key process intelligent quality detection, product information management, automatic identification technical facilities and automatic logistics equipment, wherein the production data acquisition and analysis automatically generates a production plan according to the content of a sales plan.
Description
Technical Field
The invention relates to the field of production of pharmaceutic adjuvants, in particular to a control system of an automatic production line of pharmaceutic adjuvants.
Background
The pharmaceutic adjuvant is a general term for all other materials added for making a medicine into a proper dosage form, is a substance added for the purpose of keeping the stability, safety or homogeneity of the preparation when the preparation is formed, or for the purpose of adapting the characteristics of the preparation to promote dissolution and slow release, and has no physiological activity, stable property and no reaction with the medicine, and does not influence the content determination of the medicine.
The existing production of pharmaceutic adjuvants needs manual customization to arrange a production plan, production can not be timely adjusted and allocated according to production conditions, the production process needs manual monitoring of the production conditions for feedback, manpower and material resources are consumed, the real-time feedback rate is low, the production quality is not easy to control, the production efficiency is low, the production and allocation information of materials needs manual statistics and recording, the use conditions of the materials can not be timely fed back, errors are easy to generate, and the storage and delivery statistics of finished products are troublesome.
Disclosure of Invention
The invention aims to: in order to solve the problems that the production plan needs to be customized and arranged manually in the existing production of the pharmaceutic adjuvant, the production cannot be adjusted and allocated in time according to the production condition, the production condition needs to be monitored manually for feedback in the production process, manpower and material resources are consumed, the real-time feedback rate is low, the production quality is not easy to control, the production efficiency is low, the production and allocation information of materials needs to be counted and recorded manually, the use condition of the materials cannot be fed back in time, errors are easy to generate, and the storage and delivery statistics of finished products are troublesome, the control system for the automatic production line of the pharmaceutic adjuvant is provided.
The invention provides a pharmaceutic adjuvant automatic production line control system, which comprises production data acquisition and analysis, production equipment running state monitoring, key process intelligent quality detection, product information management, an automatic identification technology facility and an automatic logistics device, wherein the production data acquisition and analysis automatically generates a production plan according to the content of a sales plan and is issued to a workshop central control system by the system, the central control system allocates production processes of production lines according to the production plan, the production equipment running state monitoring acquires the running state of the equipment in real time and feeds the running state back to the central control system, the central control system analyzes and processes the collected data to each terminal according to prestored data, the key process intelligent quality detection acquires and transmits the current production conditions in real time in the production process and transmits the production conditions to the central control system in real time, the central control system corrects reaction parameters and set standards, automatically alarms when deviation occurs and automatically or manually adjusts and removes the abnormality in a P L C system, the product information management monitors and device control the production process data in detail through an MES system, the automatic identification technology sets the production line and automatically records the product production process by using two-dimensional identification codes.
Preferably, the production data acquisition and analysis includes quantity, required raw material variety, proportion and distribution according to key information in a production plan, the production data acquisition and analysis collects and transmits data acquisition of current production conditions, production quantity and production links in real time in the production process, and packed data are transmitted to the central control system after production is completed.
Preferably, the operation state monitoring of the production equipment is realized by automatically acquiring relevant data parameters of an air supply system, a reaction kettle, an acid dissolving kettle, a centrifugal machine, a stripping machine, a pulverizer, a double-effect alcohol recovery device and a metering tank through a system for recording and analyzing, and acquiring an operation mode and state, a feeding amount, a temperature, a pressure, a rotating speed, a batching concentration, a production quantity, whether an abnormal alarm exists or not and the generated abnormal content equipment state in real time through recording and analyzing, and the central control system automatically adjusts the operation of the production line according to the abnormal alarm type.
Preferably, the key process intelligent quality detection collects data including reaction time, temperature, pressure, liquid level, equipment motor current, rotation rate and current of each section in real time in the production process, and transmits the data to a central control system in real time.
Preferably, the MES system realizes real-time acquisition of process yield, work order product transfer status and detailed production process data of test parameters through technical monitoring and equipment control, wherein the technical monitoring and equipment control is realized by marking the identity information of a single material at a position corresponding to the back of the material according to a coding principle through a two-dimensional code laser printer when the material is split and put into a production line and accompanying the lifelong.
Preferably, the code is to pack the finished product by an electronic quantitative packaging machine and record production information.
The production line has the advantages that overall control is performed based on an automatic production line control system, a production plan is automatically generated according to the content of a sales plan and is issued to a workshop central control system, the central control system allocates production processes of the production line according to the production plan, when the automatic control system operates, the operation state of real-time acquisition equipment is fed back to the central control system, the central control system analyzes and processes the operation state to each terminal according to prestored data, the production condition is adjusted and allocated in time, the current production condition is collected and transmitted in real time in the production process and is transmitted to the central control system in real time, when a reaction parameter is deviated from a set standard, an alarm is automatically given, abnormal clearing is automatically or manually adjusted in a P L C system, the real-time feedback rate is increased, the production quality is easy to control, the production efficiency is improved, the production system realizes real-time acquisition of detailed production process data through technical monitoring and equipment control, the production line mainly adopts a two-dimensional code mode to identify and record product information, the production process state of corresponding codes is automatically calibrated through the production process, finished products are put in a quantitative production information recording packaging machine, packaging of the materials and the packaging errors are convenient to generate.
Drawings
FIG. 1 is a schematic diagram of the general structure of the present invention;
FIG. 2 is a schematic view of a process for collecting and analyzing production data according to the present invention;
FIG. 3 is a schematic view of the process of monitoring the operation status of the production equipment according to the present invention;
FIG. 4 is a schematic diagram of the key process intelligent quality detection flow of the present invention;
FIG. 5 is a schematic view of a product information management process according to the present invention;
fig. 6 is a schematic flow chart of the automatic identification technology facility and the automatic logistics equipment in the invention.
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
Referring to fig. 1-6, an automatic production line control system for pharmaceutical excipients comprises production data acquisition and analysis, production equipment running state monitoring, intelligent quality detection of key processes, product information management, automatic identification technology equipment and automatic logistics equipment, wherein the production data acquisition and analysis automatically generates a production plan according to the content of a sales plan and is issued to a workshop central control system by the system, the central control system allocates production processes of production lines according to the production plan, the production equipment running state monitoring acquires the running states of the equipment in real time and feeds the running states back to the central control system, the central control system analyzes and processes the data to each terminal according to prestored data, the intelligent quality detection of the key processes collects and transmits the current production conditions in real time in the production processes and transmits the production conditions to the central control system in real time, the central control system corrects reaction parameters and set standards, automatically alarms when the deviation occurs, automatically or manually adjusts and clears the abnormality in a P L C system, the product information management identifies the detailed production process data in real time through an MES system technology monitoring and equipment, and records the product information input by using two-dimensional codes through the production lines, and the product information coding the corresponding calibration process in the production processes.
The invention carries out overall control based on an automatic production line control system, automatically generates a production plan according to the content of a sales plan, and sends the production plan to a workshop central control system, the central control system allocates the production process of the production line according to the production plan, the running state of equipment is collected in real time and fed back to the central control system when the automatic control system runs, the central control system analyzes and processes the data to each terminal according to prestored data, so that the production condition is adjusted and allocated in time, the current production condition is collected and transmitted in real time in the production process and transmitted to the central control system in real time, when the reaction parameter deviates from the set standard, an alarm is automatically given, and abnormal clearing is automatically or manually adjusted in a P L C system, so that the real-time feedback rate is increased, the production quality is easy to control, the production efficiency is improved, an MES system realizes real-time collection of detailed production process data through technical monitoring and equipment control, the production line mainly adopts a two-dimensional code mode to identify and record putting and product information, the material state of corresponding codes is automatically calibrated through the production process, finished products are packed and record production information through an electronic quantitative packing machine.
Please refer to fig. 1 and fig. 2, the production data acquisition and analysis collects and transmits the data acquisition of the current production situation, production quantity and production link in real time in the production process according to the key information in the production plan, the production data acquisition and analysis includes quantity, required raw material variety, proportioning and distribution, and the data acquisition of the current production situation, production quantity and production link is collected and transmitted in real time in the production process, and the packed data after the production is completed is transmitted to the central control system.
Please refer to fig. 1 and fig. 3, the operation status monitoring of the production equipment automatically collects the relevant data parameters of the air supply system, the reaction kettle, the chemical acid kettle, the centrifuge, the stripper, the pulverizer, the double-effect alcohol recovery device and the metering tank for recording and analyzing, and collects the operation mode and status, the feeding amount, the temperature, the pressure, the rotation speed, the ingredient concentration, the production quantity, whether there is abnormal alarm and the status of the generated abnormal content equipment in real time through recording and analyzing, and feeds back the operation mode and status to the central control system, the central control system automatically adjusts the operation of the production line according to the type of the abnormal alarm, if the type can be automatically adjusted, the production line is automatically put into the production line after adjustment, if the type needs manual intervention, the alarm is given and, and after repairing and resetting, automatically putting into a production line.
Please refer to fig. 1 and 4, the intelligent quality detection of the key process collects data including reaction time, temperature, pressure, liquid level, current, rotation rate and current of the motor of the equipment in real time in the production process, and transmits the data to the central control system in real time.
Please refer to fig. 1 and 5, the MES system realizes real-time collection of process yield, work order product transfer status, and detailed production process data of test parameters through technical monitoring and equipment control, wherein the technical monitoring and equipment control is to mark the identity information of a single material with the corresponding position on the back of the material according to the coding principle and accompany the lifetime through a two-dimensional code laser printer when the material is split and put on the production line.
Please refer to fig. 1 and fig. 6, the codes are used for packaging the finished products by the electronic quantitative packaging machine and recording the production information, and the invention enables the MES system to automatically count and manage the material and product information according to the information recorded by planning, purchasing, producing and delivering by printing the codes on the finished products.
The system automatically generates a production plan according to the content of a sales plan by switching on a power supply, wherein key information comprises quantity, raw materials and proportion, the key information is transmitted to a central control system in a workshop by the system, the central control system allocates the production process of a production line according to the production plan, the running state of equipment including running modes and states, feeding quantity, temperature, pressure, rotating speed, batching concentration, production quantity and whether abnormal alarm exists or not and abnormal content is generated when the automatic control system runs, the central control system analyzes and processes the data to each terminal according to prestored data, current production conditions including reaction time, temperature, pressure, liquid level, equipment motor current, rotation rate and current of each section are collected and transmitted to the central control system in real time, when the reaction parameters deviate from set standards, automatic alarm is given, abnormal clearing is carried out in a P L C system through automatic or manual adjustment, the MES system carries out technical monitoring and equipment control, realizes real-time collection of process yield, work order transfer conditions, detailed production process parameter production process data, production process data identification and production process data identification, production process identification, production of finished product production and product production information are automatically recorded, finished product production efficiency is improved, and finished product production efficiency is improved through electronic coding management, and finished product production efficiency is improved.
It will be evident to those skilled in the art that the invention is not limited to the details of the foregoing illustrative embodiments, and that the present invention may be embodied in other specific forms without departing from the spirit or essential attributes thereof. The present embodiments are therefore to be considered in all respects as illustrative and not restrictive, the scope of the invention being indicated by the appended claims rather than by the foregoing description, and all changes which come within the meaning and range of equivalency of the claims are therefore intended to be embraced therein. Any reference sign in a claim should not be construed as limiting the claim concerned.
Claims (6)
1. A pharmaceutic adjuvant automatic production line control system comprises production data acquisition and analysis, production equipment running state monitoring, key process intelligent quality detection, product information management, automatic identification technology equipment and automatic logistics equipment, and is characterized in that the production data acquisition and analysis automatically generates a production plan according to the content of a sales plan, the production plan is issued to a workshop central control system by the system, the central control system allocates production processes of a production line according to the production plan, the production equipment running state monitoring acquires the running state of the equipment in real time and feeds the running state back to the central control system, the central control system analyzes and processes the data to each terminal according to prestored data, the key process intelligent quality detection acquires and transmits the current production conditions in real time in the production process and transmits the production conditions to the central control system in real time, the central control system corrects reaction parameters and set standards, automatically alarms when the correction is deviated, automatically or manually adjusts and clears the abnormality in a P L C system, the product information management monitors and equipment control detailed production process data acquisition in real time through an MES system, the automatic identification technology equipment puts in the production line in a two-dimensional code mode, and automatically records the production process of the production line and the corresponding material coding process.
2. The pharmaceutical excipient automatic production line control system according to claim 1, characterized in that: the production data acquisition and analysis system comprises a central control system and a production data acquisition and analysis system, wherein the production data acquisition and analysis system collects and transmits data acquisition of current production conditions, production quantity and production links in real time in the production process according to key information in a production plan, the number of required raw materials is included, the ratio of the required raw materials is matched, and the production data is issued.
3. The pharmaceutical excipient automatic production line control system according to claim 1, characterized in that: the production equipment running state monitoring system automatically acquires relevant data parameters of an air supply system, a reaction kettle, an acid dissolving kettle, a centrifugal machine, a stripping machine, a pulverizer, a double-effect alcohol recovery device and a metering tank through the system for recording and analyzing, and acquires running modes and states, material feeding amount, temperature, pressure, rotating speed, batching concentration, production quantity, whether abnormal alarm exists or not and the generated abnormal content equipment state in real time through recording and analyzing, and the central control system automatically adjusts the production line running according to the abnormal alarm type.
4. The pharmaceutical excipient automatic production line control system according to claim 1, characterized in that: the key process intelligent quality detection collects data including reaction time, temperature, pressure, liquid level, equipment motor current, rotation rate and current of each section in real time in the production process, and transmits the data to a central control system in real time.
5. The pharmaceutical excipient automatic production line control system according to claim 1, characterized in that: the MES system realizes real-time acquisition of process yield, work order transfer conditions and detailed test parameter production process data through technical monitoring and equipment control, and the technical monitoring and equipment control are realized by marking the identity information of a single material at the corresponding position of the back of the material according to a coding principle through a two-dimensional code laser printer when the material is split and put into a production line and accompanying the life.
6. The pharmaceutical excipient automatic production line control system according to claim 1, characterized in that: and the coding is to pack the finished product through an electronic quantitative packaging machine and record production information.
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CN202010241687.3A CN111459105A (en) | 2020-03-31 | 2020-03-31 | Pharmaceutic adjuvant automation line control system |
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CN202010241687.3A CN111459105A (en) | 2020-03-31 | 2020-03-31 | Pharmaceutic adjuvant automation line control system |
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Cited By (8)
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CN112613806A (en) * | 2020-11-25 | 2021-04-06 | 青岛北洋天青数联智能股份有限公司 | Overhead accumulation and release control system and method for door body distribution |
CN113184913A (en) * | 2021-05-21 | 2021-07-30 | 中钢天源股份有限公司 | Mn based on MES system3O4Load balancing production process |
CN113200570A (en) * | 2021-05-21 | 2021-08-03 | 中钢天源股份有限公司 | Mn based on MES system3O4Continuous production process |
CN113233509A (en) * | 2021-05-21 | 2021-08-10 | 中钢天源股份有限公司 | Mn based on MES system3O4Continuous production system |
CN113296482A (en) * | 2021-05-21 | 2021-08-24 | 中钢天源股份有限公司 | Mn based on MES system3O4Flexible production system and process |
CN113885450A (en) * | 2021-09-22 | 2022-01-04 | 江苏欧软信息科技有限公司 | MES-based alarm response system |
CN114550336A (en) * | 2022-04-26 | 2022-05-27 | 深圳丰尚智慧农牧科技有限公司 | Equipment inspection method and device, computer equipment and storage medium |
CN117391549A (en) * | 2023-12-12 | 2024-01-12 | 平利县安得利新材料有限公司 | Method and device for realizing preparation node backtracking of barium sulfate based on data circulation |
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CN114550336A (en) * | 2022-04-26 | 2022-05-27 | 深圳丰尚智慧农牧科技有限公司 | Equipment inspection method and device, computer equipment and storage medium |
CN114550336B (en) * | 2022-04-26 | 2022-12-02 | 深圳丰尚智慧农牧科技有限公司 | Equipment inspection method and device, computer equipment and storage medium |
CN117391549A (en) * | 2023-12-12 | 2024-01-12 | 平利县安得利新材料有限公司 | Method and device for realizing preparation node backtracking of barium sulfate based on data circulation |
CN117391549B (en) * | 2023-12-12 | 2024-03-08 | 平利县安得利新材料有限公司 | Method and device for realizing preparation node backtracking of barium sulfate based on data circulation |
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