CN111440580A - Aqueous APAO-based disposable medical packaging hot melt adhesive and preparation process thereof - Google Patents
Aqueous APAO-based disposable medical packaging hot melt adhesive and preparation process thereof Download PDFInfo
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- CN111440580A CN111440580A CN202010325395.8A CN202010325395A CN111440580A CN 111440580 A CN111440580 A CN 111440580A CN 202010325395 A CN202010325395 A CN 202010325395A CN 111440580 A CN111440580 A CN 111440580A
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- 239000004831 Hot glue Substances 0.000 title claims abstract description 68
- 238000004806 packaging method and process Methods 0.000 title claims abstract description 45
- XPVIQPQOGTVMSU-UHFFFAOYSA-N (4-acetamidophenyl)arsenic Chemical compound CC(=O)NC1=CC=C([As])C=C1 XPVIQPQOGTVMSU-UHFFFAOYSA-N 0.000 title claims abstract description 36
- 229920013640 amorphous poly alpha olefin Polymers 0.000 title claims abstract description 36
- 238000002360 preparation method Methods 0.000 title abstract description 9
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 31
- 239000003292 glue Substances 0.000 claims abstract description 30
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- 239000011347 resin Substances 0.000 claims abstract description 30
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- 239000000853 adhesive Substances 0.000 claims description 16
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- 238000010438 heat treatment Methods 0.000 claims description 12
- IXPNQXFRVYWDDI-UHFFFAOYSA-N 1-methyl-2,4-dioxo-1,3-diazinane-5-carboximidamide Chemical group CN1CC(C(N)=N)C(=O)NC1=O IXPNQXFRVYWDDI-UHFFFAOYSA-N 0.000 claims description 11
- 235000010413 sodium alginate Nutrition 0.000 claims description 11
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- SMZOUWXMTYCWNB-UHFFFAOYSA-N 2-(2-methoxy-5-methylphenyl)ethanamine Chemical compound COC1=CC=C(C)C=C1CCN SMZOUWXMTYCWNB-UHFFFAOYSA-N 0.000 claims description 8
- NIXOWILDQLNWCW-UHFFFAOYSA-N 2-Propenoic acid Natural products OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 claims description 8
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- AXTGDCSMTYGJND-UHFFFAOYSA-N 1-dodecylazepan-2-one Chemical compound CCCCCCCCCCCCN1CCCCCC1=O AXTGDCSMTYGJND-UHFFFAOYSA-N 0.000 claims description 7
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- MQIUGAXCHLFZKX-UHFFFAOYSA-N Di-n-octyl phthalate Natural products CCCCCCCCOC(=O)C1=CC=CC=C1C(=O)OCCCCCCCC MQIUGAXCHLFZKX-UHFFFAOYSA-N 0.000 claims description 4
- BJQHLKABXJIVAM-UHFFFAOYSA-N bis(2-ethylhexyl) phthalate Chemical compound CCCCC(CC)COC(=O)C1=CC=CC=C1C(=O)OCC(CC)CCCC BJQHLKABXJIVAM-UHFFFAOYSA-N 0.000 claims description 4
- 238000004519 manufacturing process Methods 0.000 claims description 4
- 235000012424 soybean oil Nutrition 0.000 claims description 4
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- HGQSXVKHVMGQRG-UHFFFAOYSA-N dioctyltin Chemical compound CCCCCCCC[Sn]CCCCCCCC HGQSXVKHVMGQRG-UHFFFAOYSA-N 0.000 claims description 3
- 238000007599 discharging Methods 0.000 claims description 3
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- BGYHLZZASRKEJE-UHFFFAOYSA-N [3-[3-(3,5-ditert-butyl-4-hydroxyphenyl)propanoyloxy]-2,2-bis[3-(3,5-ditert-butyl-4-hydroxyphenyl)propanoyloxymethyl]propyl] 3-(3,5-ditert-butyl-4-hydroxyphenyl)propanoate Chemical compound CC(C)(C)C1=C(O)C(C(C)(C)C)=CC(CCC(=O)OCC(COC(=O)CCC=2C=C(C(O)=C(C=2)C(C)(C)C)C(C)(C)C)(COC(=O)CCC=2C=C(C(O)=C(C=2)C(C)(C)C)C(C)(C)C)COC(=O)CCC=2C=C(C(O)=C(C=2)C(C)(C)C)C(C)(C)C)=C1 BGYHLZZASRKEJE-UHFFFAOYSA-N 0.000 claims description 2
- 229910052761 rare earth metal Inorganic materials 0.000 claims description 2
- 150000002910 rare earth metals Chemical class 0.000 claims description 2
- 239000007787 solid Substances 0.000 abstract description 7
- 239000007788 liquid Substances 0.000 abstract description 4
- 230000004888 barrier function Effects 0.000 abstract 1
- 230000001954 sterilising effect Effects 0.000 description 12
- 238000004659 sterilization and disinfection Methods 0.000 description 11
- IAYPIBMASNFSPL-UHFFFAOYSA-N Ethylene oxide Chemical compound C1CO1 IAYPIBMASNFSPL-UHFFFAOYSA-N 0.000 description 8
- 239000011248 coating agent Substances 0.000 description 6
- 238000000576 coating method Methods 0.000 description 6
- 238000005507 spraying Methods 0.000 description 5
- 238000001035 drying Methods 0.000 description 4
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- 239000010408 film Substances 0.000 description 4
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- YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 description 3
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- AEMOLEFTQBMNLQ-AZLKCVHYSA-N (2r,3s,4s,5s,6r)-3,4,5,6-tetrahydroxyoxane-2-carboxylic acid Chemical compound O[C@@H]1O[C@@H](C(O)=O)[C@@H](O)[C@H](O)[C@@H]1O AEMOLEFTQBMNLQ-AZLKCVHYSA-N 0.000 description 2
- AEMOLEFTQBMNLQ-SYJWYVCOSA-N (2s,3s,4s,5s,6r)-3,4,5,6-tetrahydroxyoxane-2-carboxylic acid Chemical compound O[C@@H]1O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@@H]1O AEMOLEFTQBMNLQ-SYJWYVCOSA-N 0.000 description 2
- 229920000034 Plastomer Polymers 0.000 description 2
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- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 description 1
- 229930195725 Mannitol Natural products 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
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- 230000009286 beneficial effect Effects 0.000 description 1
- 239000006227 byproduct Substances 0.000 description 1
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- 230000007797 corrosion Effects 0.000 description 1
- 238000005260 corrosion Methods 0.000 description 1
- XAYGUHUYDMLJJV-UHFFFAOYSA-Z decaazanium;dioxido(dioxo)tungsten;hydron;trioxotungsten Chemical compound [H+].[H+].[NH4+].[NH4+].[NH4+].[NH4+].[NH4+].[NH4+].[NH4+].[NH4+].[NH4+].[NH4+].O=[W](=O)=O.O=[W](=O)=O.O=[W](=O)=O.O=[W](=O)=O.O=[W](=O)=O.O=[W](=O)=O.[O-][W]([O-])(=O)=O.[O-][W]([O-])(=O)=O.[O-][W]([O-])(=O)=O.[O-][W]([O-])(=O)=O.[O-][W]([O-])(=O)=O.[O-][W]([O-])(=O)=O XAYGUHUYDMLJJV-UHFFFAOYSA-Z 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 238000005485 electric heating Methods 0.000 description 1
- 239000000839 emulsion Substances 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
- -1 ethylene, propylene, 1-butene Chemical class 0.000 description 1
- 150000004676 glycans Chemical class 0.000 description 1
- 230000007062 hydrolysis Effects 0.000 description 1
- 238000006460 hydrolysis reaction Methods 0.000 description 1
- 239000011630 iodine Substances 0.000 description 1
- 229910052740 iodine Inorganic materials 0.000 description 1
- 230000001788 irregular Effects 0.000 description 1
- 150000002576 ketones Chemical class 0.000 description 1
- 239000000594 mannitol Substances 0.000 description 1
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- 230000009965 odorless effect Effects 0.000 description 1
- 239000000825 pharmaceutical preparation Substances 0.000 description 1
- 230000000704 physical effect Effects 0.000 description 1
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- 239000002994 raw material Substances 0.000 description 1
- 238000011160 research Methods 0.000 description 1
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- 230000009967 tasteless effect Effects 0.000 description 1
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Images
Classifications
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09J—ADHESIVES; NON-MECHANICAL ASPECTS OF ADHESIVE PROCESSES IN GENERAL; ADHESIVE PROCESSES NOT PROVIDED FOR ELSEWHERE; USE OF MATERIALS AS ADHESIVES
- C09J163/00—Adhesives based on epoxy resins; Adhesives based on derivatives of epoxy resins
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09J—ADHESIVES; NON-MECHANICAL ASPECTS OF ADHESIVE PROCESSES IN GENERAL; ADHESIVE PROCESSES NOT PROVIDED FOR ELSEWHERE; USE OF MATERIALS AS ADHESIVES
- C09J11/00—Features of adhesives not provided for in group C09J9/00, e.g. additives
- C09J11/02—Non-macromolecular additives
- C09J11/04—Non-macromolecular additives inorganic
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09J—ADHESIVES; NON-MECHANICAL ASPECTS OF ADHESIVE PROCESSES IN GENERAL; ADHESIVE PROCESSES NOT PROVIDED FOR ELSEWHERE; USE OF MATERIALS AS ADHESIVES
- C09J11/00—Features of adhesives not provided for in group C09J9/00, e.g. additives
- C09J11/02—Non-macromolecular additives
- C09J11/06—Non-macromolecular additives organic
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09J—ADHESIVES; NON-MECHANICAL ASPECTS OF ADHESIVE PROCESSES IN GENERAL; ADHESIVE PROCESSES NOT PROVIDED FOR ELSEWHERE; USE OF MATERIALS AS ADHESIVES
- C09J11/00—Features of adhesives not provided for in group C09J9/00, e.g. additives
- C09J11/08—Macromolecular additives
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L2201/00—Properties
- C08L2201/08—Stabilised against heat, light or radiation or oxydation
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L2203/00—Applications
- C08L2203/02—Applications for biomedical use
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L2205/00—Polymer mixtures characterised by other features
- C08L2205/03—Polymer mixtures characterised by other features containing three or more polymers in a blend
- C08L2205/035—Polymer mixtures characterised by other features containing three or more polymers in a blend containing four or more polymers in a blend
Abstract
The invention discloses an aqueous APAO-based disposable medical packaging hot melt adhesive and a preparation process thereof, wherein the aqueous APAO-based disposable medical packaging hot melt adhesive comprises 20-35% of matrix resin, 0-3% of A glue, 50-65% of solvent oil, 10-15% of ethanol and 1-1.5% of auxiliary materials. The traditional hot melt adhesive is solid at normal temperature, needs to be melted at high temperature and then bonded when in use, and has high viscosity after melting, poor fluidity and inconvenient use; the invention provides an aqueous APAO-based disposable medical packaging hot melt adhesive and a preparation process thereof, wherein the aqueous APAO-based disposable medical packaging hot melt adhesive is liquid at normal temperature, has moderate viscosity, can be brushed, sprayed, soaked and sprayed, saves a large amount of electric power compared with a solid hot melt adhesive, and still has barrier property after being sterilized.
Description
Technical Field
The invention relates to the technical field of hot melt adhesives, in particular to an aqueous APAO-based disposable medical packaging hot melt adhesive and a preparation process thereof.
Background
In the production of disposable medical sterilization packages, three types of schemes are currently used: 1. tyvek or high temperature sterilized paper. 2. And (4) bonding with a solvent type hot melt adhesive. 3. And (5) bonding by using a water-based hot melt adhesive.
In the first scheme, the high-temperature self-adhesive paper is mainly imported into France, and only the self-adhesive paper can be compounded with films such as PE, PP, CPP and the like, so the high-temperature self-adhesive paper has the same Tyvek strength, and the material is generally used in occasions with high value and high requirements due to extremely high price and has a limited application range.
In the second scheme, the solvent type hot melt adhesive is suitable for paper-thin film and paper-laminating paper, has low cost and is generally applied at present, but a large amount of toluene and solvent gasoline need to be released in the gluing process, so that the potential safety hazard is high, and the atmospheric environment is also greatly polluted.
In the third scheme, the water-based hot melt adhesive is suitable for paper-film.
The water-based hot melt adhesive is applied to bonding of medical packaging bags, after ethylene oxide sterilization treatment is adopted in the existing medical packaging bags, glue at the bonding position can be melted to bond articles in the packaging bags, paper bags are easily torn when the packaging paper bags are opened for sealing, inconvenience in use is brought, and if gamma ray sterilization is adopted, components in the water-based hot melt adhesive are easily destroyed, so that the physical performance of the water-based hot melt adhesive is influenced. Therefore, the applicant proposes and researches a new water-based APAO (ammonium paratungstate) based disposable medical packaging hot melt adhesive with high temperature resistance and proper peel strength and a preparation process thereof.
Disclosure of Invention
The invention aims to solve the defects in the prior art, and provides an aqueous APAO-based disposable medical packaging hot melt adhesive and a preparation process thereof.
In order to achieve the purpose, the invention adopts the following technical scheme:
an aqueous APAO-based disposable medical packaging hot melt adhesive comprises the following components: 20-35% of matrix resin, 0-3% of A glue, 50-65% of solvent oil, 10-15% of ethanol and 1-1.5% of auxiliary materials,
in the aqueous APAO-based disposable medical packaging hot melt adhesive, the matrix resin is an epoxy resin structural adhesive,
the A glue is a composition of amorphous propylene copolymer, waterborne polyurethane and medical acrylic acid.
As a preferred technical scheme of the invention, the hot melt adhesive comprises the following components: 25% of matrix resin, 1.5% of A glue, 60% of solvent oil, 12% of ethanol and 1.5% of auxiliary materials.
As a preferred technical scheme of the invention, the solvent oil is medical-grade azone.
The water-based hot melt adhesive is unstable due to the fact that alcohol is used as a solvent, and the storage life of the water-based APAO-based disposable medical packaging hot melt adhesive is shortened. In order to improve the stability of the aqueous hot melt adhesive, as a preferred technical scheme of the invention, the solvent oil is medical-grade azone. The ketones can significantly prolong the shelf life of the aqueous APAO-based disposable medical packaging hot melt adhesive. The medical azone has colorless to yellowish liquid, and is odorless and tasteless. Insoluble in water and soluble in ethanol.
As a preferred technical scheme of the invention, the auxiliary materials are antioxidant, plasticizer, stabilizer and cold-resistant agent, and the weight ratio of the antioxidant to the plasticizer to the stabilizer to the cold-resistant agent is 13: 100:13: 13.
as a preferred technical scheme of the invention, the antioxidant, the plasticizer and the cold-resistant agent are respectively an antioxidant 1010, epoxidized soybean oil and dioctyl phthalate, and the stabilizer is sodium alginate or a mixture of rare earth and dioctyl tin.
A preparation process of a water-based APAO-based disposable medical packaging hot melt adhesive comprises the following steps:
s1: preparing glue A: mixing waterborne polyurethane and medical acrylic acid, heating to 50-80 ℃, reacting for 2-4 h, and naturally cooling to room temperature; then, adding the amorphous propylene copolymer at 30-120 ℃, and reacting for 0.5-5 h to obtain glue A;
s2, pouring the matrix resin into a pulverizer, and pulverizing the matrix resin;
s3: selecting and weighing matrix resin, ethanol and solvent oil according to a proportion, then putting the matrix resin, the ethanol and the solvent oil which are weighed according to the proportion into a stirring kettle, heating the stirring kettle to 70-80 ℃ for melting, and then starting the stirring kettle for stirring until the matrix resin is uniformly dissolved to form a molten mixture A;
s4, adding sodium alginate into the molten mixture A in a reaction kettle, filling nitrogen into the reaction kettle, stirring under the protection of the nitrogen, and banburying at the temperature of 120-130 ℃ to obtain a mixture B;
s5: adding the glue A and other auxiliary materials into the molten mixture B, heating to 140 ℃, stirring again for 1 hour under the condition of vacuum degree of 1-1.2 Pa, vacuumizing to remove bubbles, discharging, and cooling to room temperature to obtain the aqueous APAO-based disposable medical packaging hot melt adhesive;
s6: inspecting the solid content and viscosity of the glue material uniformly stirred in the step S5, and properly blending according to inspection data;
s7: and sealing the rubber materials qualified in the step S6, labeling, and transferring and storing the sealed rubber materials.
In a preferred embodiment of the present invention, in S1, the matrix resin is pulverized into small particles having a diameter of 30 μm or less.
As a preferred technical scheme of the invention, when the normal temperature in the rubber production process is lower than 20 ℃, a heating device in a stirring kettle is used for heating.
Application of an aqueous APAO-based disposable medical packaging hot melt adhesive for protection in medical packaging bags.
The A glue is a composition emulsion of amorphous propylene copolymer, waterborne polyurethane and medical acrylic acid.
When ethylene oxide is used for sterilization, the ethylene oxide sterilization chamber is a sealed space which utilizes water vapor for heating, heat preservation and moisture preservation and can be added with positive pressure and negative pressure. Controlling the temperature of the sterilization chamber at 40-50 ℃, and preserving the heat for 2 hours; and after the heat preservation time is reached, humidifying the sterilization chamber, keeping the humidity at 40-60%, pre-vacuumizing the sterilization chamber, and keeping the pressure difference of 3 kPa. Sterilizing with gamma ray for 180S, and performing 6 times of irradiation process. The physical and chemical properties of the gel can be damaged by the temperature, humidity, pressure and ethylene oxide gas in a sterilization room. Gamma ray sterilization can also destroy the physical and chemical properties of the gel.
The A glue is bonded in the epoxy resin structural adhesive, the obtained hot melt adhesive has the characteristics of strong bonding force, good thermal stability and the like, the aqueous polyurethane and the medical acrylic acid enter the main chain of the amorphous propylene copolymer in a chemical bond form to obtain the A glue, and the A glue is bonded with the epoxy resin structural adhesive, so that the thermal stability, the moisture resistance and the pressure resistance of the hot melt adhesive are greatly improved. The amorphous propylene copolymer effectively avoids the polymerization reaction between the adhesive A and the surface of the epoxy resin structural adhesive caused by gamma ray radiation, improves the stability of the hot melt adhesive, and avoids the damage to the physical and chemical properties of the adhesive caused by temperature, humidity, pressure, ethylene oxide gas, gamma rays and the like.
Amorphous propylene copolymers, commonly known as apao (amorphus poly alpha olefin), are random copolymers obtained by polymerization of alpha-olefins (e.g., ethylene, propylene, 1-butene, etc.) and are a plastomer material. The material is a low molecular weight amorphous plastomer material which is generated by polymerization reaction of alpha-olefin and has an amorphous and irregular arrangement state on a microstructure. The amorphous propylene copolymer can effectively reduce the corrosion sensitivity of ethylene oxide gas, the amorphous propylene copolymer increases the colloid fluidity to facilitate the volatilization of a solvent and avoid the formation of cavities, and the formation of any drying stress is reduced in the process of combining the A glue and the matrix resin. The waterborne polyurethane improves the adhesiveness of the amorphous propylene copolymer and sodium alginate, improves the heat resistance of the hot melt adhesive, effectively improves the moisture resistance of the hot melt adhesive, and keeps the physical properties of the hot melt adhesive stable when the medical packaging bag adopts ethylene oxide for sterilization, so that the medical packaging bag has good heat resistance and hydrolysis resistance and low water absorption rate.
The sodium alginate is a by-product after iodine and mannitol are extracted from brown algae kelp or gulfweed, molecules of the sodium alginate are connected by β -D-mannuronic acid (β -D-mannuronic acid, M) and α -L-guluronic acid (α -L-guluronic acid, G) according to (1 → 4) bonds, the sodium alginate is a natural polysaccharide and has stability, dissolubility, viscosity and safety required by auxiliary materials of pharmaceutical preparations.
The invention has the beneficial effects that:
the raw materials used by the aqueous APAO-based disposable medical packaging hot melt adhesive provided by the invention meet the environmental protection requirement, the traditional hot melt adhesive is solid at normal temperature, and needs to be melted at high temperature and then bonded, and the melted hot melt adhesive has high viscosity, poor fluidity and inconvenient use; the water-based hot melt adhesive prepared by the invention is liquid at normal temperature, has moderate viscosity, can be brushed, drenched, soaked and sprayed, has low use temperature compared with solid hot melt adhesives, greatly saves electric power, is convenient for medical disposable packaging and smearing, and can be stored at low temperature aiming at certain medical supplies.
The medical packaging bag prepared by the aqueous APAO-based disposable medical packaging hot melt adhesive can resist high temperature and sterilization treatment. The aqueous APAO-based disposable medical packaging hot melt adhesive prepared by the invention has the advantages of high temperature resistance, no pressure sensitivity and proper peel strength.
Drawings
FIG. 1 is a flow chart of the manufacturing process of the aqueous APAO-based disposable medical packaging hot melt adhesive of the present invention.
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all embodiments.
Example one
An aqueous APAO-based disposable medical packaging hot melt adhesive comprises the following components: 25 percent of matrix resin, 1.5 percent of A glue, 60 percent of medical grade azone, 12 percent of ethanol and 1.5 percent of sodium alginate,
in the aqueous APAO-based disposable medical packaging hot melt adhesive, the matrix resin is an epoxy resin structural adhesive,
the A glue is a composition of amorphous propylene copolymer, waterborne polyurethane and medical acrylic acid.
A preparation process of a water-based APAO-based disposable medical packaging hot melt adhesive comprises the following steps:
s1: preparing glue A: mixing waterborne polyurethane and medical acrylic acid, heating to 50-80 ℃, reacting for 2-4 h, and naturally cooling to room temperature; then, adding the amorphous propylene copolymer at 30-120 ℃, and reacting for 0.5-5 h to obtain glue A;
s2, pouring the matrix resin into a pulverizer, and pulverizing the matrix resin;
s3: selecting and weighing matrix resin, ethanol and solvent oil according to a proportion, then putting the matrix resin, the ethanol and the solvent oil which are weighed according to the proportion into a stirring kettle, heating the stirring kettle to 70-80 ℃ for melting, and then starting the stirring kettle for stirring until the matrix resin is uniformly dissolved to form a molten mixture A;
s4, adding sodium alginate into the molten mixture A in a reaction kettle, filling nitrogen into the reaction kettle, stirring under the protection of the nitrogen, and banburying at the temperature of 120-130 ℃ to obtain a mixture B;
s5: adding the glue A and other auxiliary materials into the molten mixture B, heating to 140 ℃, stirring again for 1 hour under the condition of vacuum degree of 1-1.2 Pa, vacuumizing to remove bubbles, discharging, and cooling to room temperature to obtain the aqueous APAO-based disposable medical packaging hot melt adhesive;
s6: inspecting the solid content and viscosity of the glue material uniformly stirred in the step S5, and properly blending according to inspection data;
s7: and sealing the rubber materials qualified in the step S6, labeling, and transferring and storing the sealed rubber materials.
In a preferred embodiment of the present invention, in S1, the matrix resin is pulverized into small particles having a diameter of 30 μm or less.
Example two
An aqueous APAO-based disposable medical packaging hot melt adhesive comprises the following components: 25% of matrix resin, 1.61% of A glue, 60% of medical grade azone, 12% of ethanol, 10100.13% of antioxidant, 1% of epoxidized soybean oil, 0.13% of sodium alginate, 0.13% of dioctyl phthalate, and 13% of antioxidant, plasticizer, stabilizer and cold-resistant agent in weight ratio: 100:13: 13.
EXAMPLE III
An aqueous APAO-based disposable medical packaging hot melt adhesive comprises the following components: 20% of matrix resin, 1% of A glue, 65% of medical grade azone, 12.61% of ethanol, 10100.13% of antioxidant, 1% of epoxidized soybean oil, 0.13% of a mixture of dioctyl tin, 0.13% of dioctyl phthalate, and the weight ratio of the antioxidant, the plasticizer, the stabilizer and the cold-resistant agent is 13: 100:13: 13.
comparing the first, second and third examples, in terms of the performance of the prepared hot melt adhesive, the adhesive prepared by the formula in the first example is used for a paper-PE film product, the adhesive coating amount is 2-3g/m2, and the peeling force range is 2.0-2.8N/15 mm; the adhesive prepared by the formula in the second embodiment is used for paper-laminating paper, the adhesive coating amount is 2-3g/m2, and the peeling force range is 1.35-1.8N/15 mm; the adhesive prepared by the formula in the third embodiment is suitable for paper-paper products, the coating thickness is 8-10g/m2, the peeling force is 1.3-2.0N/15mm, and the peeling force is basically unchanged after ethylene oxide sterilization or gamma ray sterilization treatment.
The water-based APAO-based disposable medical packaging hot melt adhesive is not a liquid hot melt adhesive with a lower softening point, nor a hot melt adhesive dissolved in water, and forms a hot melt adhesive film between two material layers after coating and drying, and the use modes of the invention are various, for example, a hot melt adhesive spraying machine (the temperature is adjusted to 150 ℃) is adopted, the hot melt adhesive can be continuously used, the large and medium-sized hot melt adhesive spraying machine is adopted for coating in an assembly line (the temperature is adjusted to 150 ℃), the spraying is adopted, the spraying is applied to the surfaces of products with various shapes and different types, and the spraying mode can not be carried out by adopting any solid hot melt adhesive, the hot melt adhesive is manually brushed after being heated in an electric heating pot, the two materials are compounded at normal temperature, and then the two materials are melted and pressed for 2-3 minutes under; or firstly coating the glue on a base material, drying the surface, then melting the glue under the temperature conditions of an oven/drying tunnel and the like, and then pressing the composite surface material.
The above description is only for the preferred embodiment of the present invention, but the scope of the present invention is not limited thereto, and any person skilled in the art should be considered to be within the technical scope of the present invention, and the technical solutions and the inventive concepts thereof according to the present invention should be equivalent or changed within the scope of the present invention.
Claims (7)
1. The water-based APAO-based disposable medical packaging hot melt adhesive is characterized by comprising the following components: 20-35% of matrix resin, 1-3% of A glue, 50-65% of solvent oil, 10-15% of ethanol and 1-1.5% of auxiliary materials,
in the aqueous APAO-based disposable medical packaging hot melt adhesive, the matrix resin is an epoxy resin structural adhesive,
the A glue is a composition of amorphous propylene copolymer, waterborne polyurethane and medical acrylic acid.
2. The aqueous APAO-based disposable medical packaging hot melt adhesive according to claim 1, which comprises the following components: 25% of matrix resin, 1.5% of A glue, 60% of solvent oil, 12% of ethanol and 1.5% of auxiliary materials.
3. The aqueous APAO-based disposable medical packaging hot melt adhesive according to claim 1, wherein the solvent oil is selected from medical grade azone.
4. The aqueous APAO-based disposable medical packaging hot melt adhesive according to claim 1, wherein the auxiliary materials are one or more combinations of antioxidants, plasticizers, stabilizers and cold resistance agents.
5. The aqueous APAO-based disposable medical packaging hot melt adhesive according to claim 1, wherein the antioxidant, plasticizer and cold-resistant agent are respectively antioxidant 1010, epoxidized soybean oil, dioctyl phthalate, and the stabilizer is sodium alginate or a mixture of rare earth and dioctyl tin.
6. The process for preparing the aqueous APAO-based disposable medical packaging hot melt adhesive according to claim 1, comprising the following steps:
s1: preparing glue A: mixing waterborne polyurethane and medical acrylic acid, heating to 50-80 ℃, reacting for 2-4 hours, and naturally cooling to room temperature; then, adding the amorphous propylene copolymer at 30-120 ℃, and reacting for 0.5-5 h to obtain glue A;
s2, pouring the matrix resin into a pulverizer, and pulverizing the matrix resin;
s3: selecting and weighing matrix resin, ethanol and solvent oil according to a proportion, then putting the matrix resin, the ethanol and the solvent oil which are weighed according to the proportion into a stirring kettle, heating the stirring kettle to 70-80 ℃ for melting, and then starting the stirring kettle for stirring until the matrix resin is uniformly dissolved to form a molten mixture A;
s4, adding sodium alginate into the molten mixture A in a reaction kettle, filling nitrogen into the reaction kettle, stirring under the protection of the nitrogen, and banburying at the temperature of 120-130 ℃ to obtain a mixture B;
s5: and adding the glue A and other auxiliary materials into the molten mixture B, heating to 140 ℃, stirring again for 1 hour under the condition of a vacuum degree of 1-1.2 Pa, vacuumizing to remove bubbles, discharging, and cooling to room temperature to obtain the aqueous APAO-based disposable medical packaging hot melt adhesive.
7. The manufacturing process of the aqueous APAO-based disposable medical packaging hot melt adhesive according to claim 5, wherein the matrix resin in S1 is crushed into small particles with the diameter of 30 μm or less.
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