CN111440349A - Preparation method of sodium alginate antibacterial dressing - Google Patents

Preparation method of sodium alginate antibacterial dressing Download PDF

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CN111440349A
CN111440349A CN202010484866.XA CN202010484866A CN111440349A CN 111440349 A CN111440349 A CN 111440349A CN 202010484866 A CN202010484866 A CN 202010484866A CN 111440349 A CN111440349 A CN 111440349A
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tmpyp
tpps
solution
film
mxene
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CN111440349B (en
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曹美文
丁榛
张宇欣
张子瑾
刘祯
赵琳杰
孙路
王生杰
夏永清
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Qingdao Huachuang Plastic Industry Co ltd
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China University of Petroleum East China
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    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J7/00—Chemical treatment or coating of shaped articles made of macromolecular substances
    • C08J7/12—Chemical modification
    • C08J7/14—Chemical modification with acids, their salts or anhydrides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
    • A61L26/0004—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing inorganic materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
    • A61L26/0009—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials
    • A61L26/0023—Polysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
    • A61L26/0061—Use of materials characterised by their function or physical properties
    • A61L26/0066—Medicaments; Biocides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
    • A61L26/0061—Use of materials characterised by their function or physical properties
    • A61L26/008—Hydrogels or hydrocolloids
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J5/00—Manufacture of articles or shaped materials containing macromolecular substances
    • C08J5/18—Manufacture of films or sheets
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/10—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing inorganic materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
    • A61L2300/216—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials with other specific functional groups, e.g. aldehydes, ketones, phenols, quaternary phosphonium groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J2305/00—Characterised by the use of polysaccharides or of their derivatives not provided for in groups C08J2301/00 or C08J2303/00
    • C08J2305/04—Alginic acid; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08K—Use of inorganic or non-macromolecular organic substances as compounding ingredients
    • C08K3/00—Use of inorganic substances as compounding ingredients
    • C08K3/10—Metal compounds
    • C08K3/12—Hydrides
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08K—Use of inorganic or non-macromolecular organic substances as compounding ingredients
    • C08K5/00—Use of organic ingredients
    • C08K5/16—Nitrogen-containing compounds
    • C08K5/34—Heterocyclic compounds having nitrogen in the ring
    • C08K5/3467—Heterocyclic compounds having nitrogen in the ring having more than two nitrogen atoms in the ring

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The invention relates to a preparation method of a biomedical dressing, belonging to the technical field of preparation of medical materials. The method is to mix two-dimensional titanium carbide (Ti)3C2) Porphyrin (TMPyP/TPPS) mixed solution and Sodium Alginate (SA) in a certain proportion (Ti)3C2: the mass ratio of TMPyP/TPPS is 10:1-5: 1; SA 1-2 wt% is mixed to prepare a dressing, and calcium chloride (CaCl) 1-2 wt% is added2) Drying the solution to form a film. The film has good antibacterial property and is normalThe cells are substantially non-toxic. The invention has simple process, and the prepared dressing has the characteristics of antibacterial property, biocompatibility and the like.

Description

Preparation method of sodium alginate antibacterial dressing
Technical Field
The invention relates to a preparation method of a biomedical dressing, belonging to the technical field of preparation of medical materials. The method is to mix two-dimensional titanium carbide (Ti)3C2) Porphyrin (TMPyP/TPPS) mixed solution and Sodium Alginate (SA) in a certain proportion (Ti)3C2: the mass ratio of TMPyP/TPPS is 10:1-5: 1; SA 1-2 wt% is mixed to prepare a dressing, and calcium chloride (CaCl) 1-2 wt% is added2) Drying the solution to form a film. The membrane has good antibacterial performance and basically has no toxicity to normal cells. The invention has simple process, and the prepared dressing has the characteristics of antibacterial property, biocompatibility and the like.
Technical Field
Sodium alginate is a by-product obtained by extracting iodine and mannitol from brown algae such as herba Zosterae Marinae or Sargassum, is a natural polysaccharide, has stability, solubility, viscosity and safety required by medicinal adjuvants, and has good hydrophilicity, biocompatibility and biodegradability. Sodium alginate can be used as a carrier of the dressing, but sodium alginate has no antibacterial property, and some antibacterial substances can be added.
MXene is a material similar to graphene oxide, has wide surface area, hydrophilicity, negative surface charge, antibacterial property in a solution and concentration dependence, and has better antibacterial effect along with the increase of the concentration.
Porphyrin photodynamic therapy (PDT) is a new method for treating neoplastic diseases using photosensitizing drugs and laser activation. The tumor site is irradiated with specific wavelength to activate the photosensitive medicine gathered selectively in tumor tissue and trigger photochemical reaction to destroy tumor. The photosensitizing drugs in the new generation of photodynamic therapy (PDT) transfer energy to the surrounding oxygen, generating highly reactive singlet oxygen. Singlet oxygen can undergo oxidation reaction with nearby biological macromolecules to generate cytotoxicity and further kill cells.
In the previous research, the porphyrin photodynamic therapy generates singlet oxygen under the irradiation of visible light to destroy cell tissues until death, thereby achieving the antibacterial effect. MXene and porphyrin are compounded, and the respective advantages are utilized to be added into sodium alginate to prepare the film, so that the antibacterial function on surface wounds is achieved.
Disclosure of Invention
The preparation method of the sodium alginate antibacterial dressing is characterized by comprising the following steps:
(1) mixing MXene-TMPyP/TPPS and SA at a certain ratio (Ti)3C2: the mass ratio of TMPyP/TPPS is 10:1-5: 1; SA 1-2 wt%) in ultrapure water, and mixing MXene-TMPyP/TPPS and SA uniformly by using a magnetic stirrer and vortex ultrasound.
(2) Adding 1-2 wt% of CaCl into the uniformly mixed solution2The solution is continuously stirred and dried to form a film.
(3) After forming the film, 2% CaCl was used2Soaking in the solution for 1-2 hr, washing with distilled water for 3-5 times, and vacuum drying at 50-60 deg.C.
Compared with the prior art, the invention has the following advantages: (1) the gel has the characteristics of high biocompatibility, economy, practicability, safety and no toxicity. (2) The antibacterial substance is introduced into the sodium alginate gel to make it have antibacterial effect. (3) The dressing can achieve the antibacterial effect without using antibiotics, and avoid drug resistance.
Drawings
FIG. 1 is a graph showing the opacity of the membrane (sodium calcium alginate ion composite membrane and MXene and TMPyP/TPPS) in example 1 of the present invention.
FIG. 2 shows the generation of different concentrations of TMPyP/TPPS singlet oxygen at different times in example 1 of the present invention.
FIG. 3 shows the antibacterial test of the membrane (sodium calcium alginate ion composite membrane and MXene and TMPyP/TPPS) in example 1 of the present invention.
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
Example 1:
(1) MXene solution of 100. mu.g/m L was prepared, and after MXene was well dispersed in water, porphyrins (10. mu.g/m L, 20. mu.g/m L, 50. mu.g/m L, 100. mu.g/m L, 150. mu.g/m L, 200. mu.g/m L, 260. mu.g/m L) at different concentrations were added to form MXene/porphyrin complex.
(2) According to the proportion of distilled water and sodium alginate in the literature (22m L: 0.25g), adding sodium alginate, stirring at 700rpm/min for 1 h.
(3) Stirring was continued for 1h at the rotation speed after addition according to the ratio of distilled water to calcium chloride in the literature (10m L: 0.0159 g).
(4) The final mixture was poured into a petri dish and placed in an oven at 37 ℃ for 24h to form a thin film.
(5) Finally, the synthetic film is soaked in 2 percent calcium chloride water solution for 2 hours, washed with distilled water for three times, and then dried in vacuum at 60 ℃.
(6) And after drying, removing the film, taking the film with the same size, measuring the absorbance value at 600nm by using an ultraviolet spectrophotometer, and plotting.
Example 2:
(1) first, MXene 100. mu.g/m L was prepared, and MXene porphyrin mixed solution was prepared after fixing MXene concentration and setting MXene concentration at 10 and 20. mu.g/m L.
(2) 9, 10-anthracene dipropionic acid disodium salt (ADPA) solution is prepared, and the concentration is 20 mu mol/L.
(3) Irradiating with light for 0min, 10min, 20min, 30min, 60min, 90min, and 120 min.
(4) And (4) carrying out ultraviolet detection on the solution after illumination, and observing the change of the absorbance value at about 355 nm.
Example 3:
(1) the synthesized film was cut into a square of 3cm, and the PE film was cut into a square of 2.4 cm.
(2) Wiping the two materials with 75% alcohol, and ultraviolet sterilizing in clean bench for 15 min.
(3) Diluting Escherichia coli, taking OD at 600nm of about 0.1, ten-fold diluting to make OD between 0.001-0.01, and corresponding bacterial liquid concentration of 105-107CFU/mL。
(4) The diluted bacterial solution 80 μ L with appropriate concentration was dropped on the surface of the sterilized material, and the PE film was covered on the surface of the sterilized material to uniformly distribute the bacterial solution on the material.
(5) And putting the materials of which the bacteria liquid is dripped into a 37 ℃ incubator for 24h culture, wherein one group is cultured at 37 ℃ in a dark place, and the other group is cultured at 37 ℃ in a light way.
(6) The PE film was peeled off and the material was eluted with 3m L eluent, which was washed uniformly, approximately 10 times.
(7) And taking out 100 mu L of the eluted bacterial liquid, and dripping the bacterial liquid on a solid culture medium, and coating the bacterial liquid by using an inoculating loop to uniformly distribute the bacterial liquid in the solid culture medium.
(8) Culturing in an incubator at 37 ℃.
(9) And observing and taking pictures after 18-24 h.

Claims (6)

1. The preparation method of the sodium alginate antibacterial dressing is characterized by comprising the following steps:
(1) mixing MXene-TMPyP/TPPS and SA at a certain ratio (Ti)3C2: the mass ratio of TMPyP/TPPS is 10:1-5: 1; SA 1-2 wt%) in ultrapure water, and mixing MXene-TMPyP/TPPS and SA uniformly by using a magnetic stirrer and vortex ultrasound.
(2) Adding 1-2 wt% of CaCl into the uniformly mixed solution2The solution is continuously stirred and dried to form a film.
(3) After forming the film, 2% CaCl was used2Soaking in the solution for 2 hr, washing with distilled water for 3-5 times, and vacuum drying at 50-60 deg.C.
2. The method of claim 1, wherein MXene and TMPyP/TPPS (mass ratio of 10:1 to 5:1) are dispersed in 1% -2% wt of SA solution, and MXene is dispersed uniformly by vortex ultrasound, then TMPyP/TPPS is added, and MXene-TMPyP/TPPS and SA are mixed uniformly.
3. The method according to claim 1, characterized in that CaCl2The concentration of the solution is 1-2 wt%.
4. The method according to claim 1, wherein the film is dried for about 16 to 24 hours.
5. The method of claim 1, wherein drying to form a film is followed by the use of 2% CaCl2Soaking in the solution for 1-2 h.
6. The method of claim 1, wherein the soaking is followed by rinsing with distilled water 3-5 times and vacuum drying at 50-60 ℃.
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Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112724427A (en) * 2021-01-29 2021-04-30 西北师范大学 Preparation of corn starch/sodium alginate/MXene composite hydrogel and application of composite hydrogel in seawater desalination
CN113694197A (en) * 2021-10-29 2021-11-26 深圳市第二人民医院(深圳市转化医学研究院) Photothermal/photodynamic synergistic tumor phototherapy reagent and preparation method and application thereof
CN113773835A (en) * 2021-09-22 2021-12-10 同济大学 Cationic porphyrin functionalized Ti3C2TxNano-sheet nonlinear nano hybrid material and preparation and application thereof
CN115058169A (en) * 2022-02-07 2022-09-16 西北工业大学 MXene-based anticorrosive and antifouling composite coating and preparation method and application thereof

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2015209417A (en) * 2014-04-30 2015-11-24 学校法人東京理科大学 Oral therapeutic agent for diseases
CN105079863A (en) * 2015-08-12 2015-11-25 中国科学院兰州化学物理研究所 Preparation method of aloe/sodium alginate double-layer hydrogel dressing
CN105669923A (en) * 2016-04-12 2016-06-15 江南大学 Photosensitive antibacterial hydrogel and preparation method thereof
CN106178979A (en) * 2016-08-31 2016-12-07 华南理工大学 High-performance two-dimensional stratiform Ti3c2mXene film and preparation method thereof and the application in water process

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2015209417A (en) * 2014-04-30 2015-11-24 学校法人東京理科大学 Oral therapeutic agent for diseases
CN105079863A (en) * 2015-08-12 2015-11-25 中国科学院兰州化学物理研究所 Preparation method of aloe/sodium alginate double-layer hydrogel dressing
CN105669923A (en) * 2016-04-12 2016-06-15 江南大学 Photosensitive antibacterial hydrogel and preparation method thereof
CN106178979A (en) * 2016-08-31 2016-12-07 华南理工大学 High-performance two-dimensional stratiform Ti3c2mXene film and preparation method thereof and the application in water process

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
AHMAD ARABI SHAMSABADI等: "Antimicrobial Mode-of-Action of Colloidal Ti3C2Tx MXene Nanosheets", 《ACS SUSTAINABLE CHEMISTRY & ENGINEERING》 *
SHARIF M. ABDELGHANY 等: "Enhanced Antitumor Activity of the Photosensitizer meso-Tetra(N‑methyl-4-pyridyl) Porphine Tetra Tosylate through Encapsulation in Antibody-Targeted Chitosan/Alginate Nanoparticles", 《BIOMACROMOLECULES》 *

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112724427A (en) * 2021-01-29 2021-04-30 西北师范大学 Preparation of corn starch/sodium alginate/MXene composite hydrogel and application of composite hydrogel in seawater desalination
CN112724427B (en) * 2021-01-29 2022-09-13 西北师范大学 Preparation of corn starch/sodium alginate/MXene composite hydrogel and application of composite hydrogel in seawater desalination
CN113773835A (en) * 2021-09-22 2021-12-10 同济大学 Cationic porphyrin functionalized Ti3C2TxNano-sheet nonlinear nano hybrid material and preparation and application thereof
CN113694197A (en) * 2021-10-29 2021-11-26 深圳市第二人民医院(深圳市转化医学研究院) Photothermal/photodynamic synergistic tumor phototherapy reagent and preparation method and application thereof
CN115058169A (en) * 2022-02-07 2022-09-16 西北工业大学 MXene-based anticorrosive and antifouling composite coating and preparation method and application thereof

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