CN111432865B - 药物递送系统及相关方法 - Google Patents

药物递送系统及相关方法 Download PDF

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Publication number
CN111432865B
CN111432865B CN201880079337.2A CN201880079337A CN111432865B CN 111432865 B CN111432865 B CN 111432865B CN 201880079337 A CN201880079337 A CN 201880079337A CN 111432865 B CN111432865 B CN 111432865B
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CN
China
Prior art keywords
drug delivery
drying
valve stem
canister
delivery device
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CN201880079337.2A
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English (en)
Chinese (zh)
Other versions
CN111432865A (zh
Inventor
J·舍伍德
D·迪顿
D·海默尔
B·福斯特
M·菲瑞特尔
S·K·德威维迪
M·L·金
F·哈姆林
小R·V·希伊
G·利比
V·奈吉
K·伍达德
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pearl Therapeutics Inc
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Pearl Therapeutics Inc
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Application filed by Pearl Therapeutics Inc filed Critical Pearl Therapeutics Inc
Priority to CN202210749962.1A priority Critical patent/CN115445033B/zh
Publication of CN111432865A publication Critical patent/CN111432865A/zh
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0001—Details of inhalators; Constructional features thereof
    • A61M15/0021—Mouthpieces therefor
    • A61M15/0025—Mouthpieces therefor with caps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/009—Inhalators using medicine packages with incorporated spraying means, e.g. aerosol cans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0075—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M11/00—Sprayers or atomisers specially adapted for therapeutic purposes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M11/00—Sprayers or atomisers specially adapted for therapeutic purposes
    • A61M11/06—Sprayers or atomisers specially adapted for therapeutic purposes of the injector type
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M11/00—Sprayers or atomisers specially adapted for therapeutic purposes
    • A61M11/06—Sprayers or atomisers specially adapted for therapeutic purposes of the injector type
    • A61M11/08—Pocket atomisers of the injector type
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0001—Details of inhalators; Constructional features thereof
    • A61M15/0021—Mouthpieces therefor
    • A61M15/0025—Mouthpieces therefor with caps
    • A61M15/0026—Hinged caps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0086—Inhalation chambers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0091—Inhalators mechanically breath-triggered
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D83/00—Containers or packages with special means for dispensing contents
    • B65D83/14—Containers for dispensing liquid or semi-liquid contents by internal gaseous pressure, i.e. aerosol containers comprising propellant
    • B65D83/38—Details of the container body
    • B65D83/384—Details of the container body the container body being an aerosol container located in an outer shell or in an external container
    • B65D83/386—Details of the container body the container body being an aerosol container located in an outer shell or in an external container actuation occurring by moving the aerosol container relative to the outer shell or external container
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/12—Aerosols; Foams
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0065—Inhalators with dosage or measuring devices
    • A61M15/0068—Indicating or counting the number of dispensed doses or of remaining doses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2202/00—Special media to be introduced, removed or treated
    • A61M2202/06—Solids
    • A61M2202/062—Desiccants
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
    • B05B11/00—Single-unit hand-held apparatus in which flow of contents is produced by the muscular force of the operator at the moment of use
    • B05B11/01—Single-unit hand-held apparatus in which flow of contents is produced by the muscular force of the operator at the moment of use characterised by the means producing the flow
    • B05B11/10—Pump arrangements for transferring the contents from the container to a pump chamber by a sucking effect and forcing the contents out through the dispensing nozzle
    • B05B11/1042—Components or details
    • B05B11/1052—Actuation means
    • B05B11/1053—Actuation means combined with means, other than pressure, for automatically opening a valve during actuation; combined with means for automatically removing closures or covers from the discharge nozzle during actuation

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Chemical & Material Sciences (AREA)
  • Dispersion Chemistry (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Mechanical Engineering (AREA)
  • Otolaryngology (AREA)
  • Containers And Packaging Bodies Having A Special Means To Remove Contents (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CN201880079337.2A 2017-10-09 2018-10-05 药物递送系统及相关方法 Active CN111432865B (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN202210749962.1A CN115445033B (zh) 2017-10-09 2018-10-05 药物递送系统及相关方法

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201762569901P 2017-10-09 2017-10-09
US62/569,901 2017-10-09
US201862639911P 2018-03-07 2018-03-07
US62/639,911 2018-03-07
PCT/US2018/054721 WO2019074799A1 (en) 2017-10-09 2018-10-05 DRUG DELIVERY SYSTEMS AND ASSOCIATED METHODS

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CN202210749962.1A Division CN115445033B (zh) 2017-10-09 2018-10-05 药物递送系统及相关方法

Publications (2)

Publication Number Publication Date
CN111432865A CN111432865A (zh) 2020-07-17
CN111432865B true CN111432865B (zh) 2022-07-19

Family

ID=66101724

Family Applications (2)

Application Number Title Priority Date Filing Date
CN201880079337.2A Active CN111432865B (zh) 2017-10-09 2018-10-05 药物递送系统及相关方法
CN202210749962.1A Active CN115445033B (zh) 2017-10-09 2018-10-05 药物递送系统及相关方法

Family Applications After (1)

Application Number Title Priority Date Filing Date
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Country Status (12)

Country Link
US (3) US11833292B2 (https=)
EP (2) EP3694590B1 (https=)
JP (2) JP7076538B2 (https=)
KR (2) KR102683072B1 (https=)
CN (2) CN111432865B (https=)
AU (2) AU2018347970B2 (https=)
CA (1) CA3078209A1 (https=)
ES (2) ES2970740T3 (https=)
IL (2) IL273713B2 (https=)
MY (1) MY201084A (https=)
SG (1) SG11202003062QA (https=)
WO (1) WO2019074799A1 (https=)

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ES2970740T3 (es) * 2017-10-09 2024-05-30 Pearl Therapeutics Inc Unidad de administración de aerosol
WO2021023878A1 (en) * 2019-08-08 2021-02-11 Jt International S.A. Aerosol generation device having closure with rigid biasing element
CA3226557A1 (en) 2021-07-09 2023-01-12 Astrazeneca Pharmaceuticals Lp Compositions, methods and systems for aerosol drug delivery
FR3126002B1 (fr) * 2021-08-03 2023-08-04 G H Mumm Et Cie Soc Vinicole De Champagne Successeur Procédé et dispositif pour stocker et contrôler l’ouverture et la fermeture d’une cartouche contenant une boisson
US20240016658A1 (en) * 2022-07-14 2024-01-18 Twenty Twenty Therapeutics Llc Non-gravitational fluid delivery device for ophthalmic applications
CN115364317B (zh) * 2022-08-25 2023-07-14 翟凌 雾化结构、双头雾化器和雾化器
WO2025129008A1 (en) * 2023-12-13 2025-06-19 Csp Technologies, Inc. Aerosol delivery device, components thereof, and methods for making the same
CN223944740U (zh) * 2023-12-19 2026-02-27 长风药业股份有限公司 呼吸致动的吸入器

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CN106620970A (zh) * 2016-10-30 2017-05-10 田中枢 一种便携式雾化给药装置

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Also Published As

Publication number Publication date
JP7479420B2 (ja) 2024-05-08
IL273713A (en) 2020-05-31
AU2024205820B2 (en) 2026-01-29
MY201084A (en) 2024-02-03
BR112020006696A2 (pt) 2020-10-06
JP7076538B2 (ja) 2022-05-27
ES2921305T3 (es) 2022-08-23
EP3694590A1 (en) 2020-08-19
EP3694590B1 (en) 2022-05-04
SG11202003062QA (en) 2020-04-29
KR102683072B1 (ko) 2024-07-08
IL302619B2 (en) 2024-06-01
IL273713B1 (en) 2023-06-01
IL302619B1 (en) 2024-02-01
KR20220110868A (ko) 2022-08-09
EP3694590A4 (en) 2021-08-18
CN111432865A (zh) 2020-07-17
JP2020536622A (ja) 2020-12-17
AU2018347970B2 (en) 2024-05-30
US11331442B2 (en) 2022-05-17
EP4091652B1 (en) 2023-11-29
ES2970740T3 (es) 2024-05-30
CN115445033B (zh) 2024-08-27
IL273713B2 (en) 2023-10-01
KR102428545B1 (ko) 2022-08-04
AU2024205820A1 (en) 2024-09-05
CN115445033A (zh) 2022-12-09
WO2019074799A1 (en) 2019-04-18
JP2022122887A (ja) 2022-08-23
EP4091652A1 (en) 2022-11-23
US20220016366A1 (en) 2022-01-20
US11833292B2 (en) 2023-12-05
IL302619A (en) 2023-07-01
US20240050670A1 (en) 2024-02-15
US20200353185A1 (en) 2020-11-12
AU2018347970A1 (en) 2020-04-23
CA3078209A1 (en) 2019-04-18
KR20200070284A (ko) 2020-06-17

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