CN111413382B - Medical smart phone system and implementation method - Google Patents
Medical smart phone system and implementation method Download PDFInfo
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- CN111413382B CN111413382B CN202010252206.9A CN202010252206A CN111413382B CN 111413382 B CN111413382 B CN 111413382B CN 202010252206 A CN202010252206 A CN 202010252206A CN 111413382 B CN111413382 B CN 111413382B
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
- G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
- G01N27/28—Electrolytic cell components
- G01N27/30—Electrodes, e.g. test electrodes; Half-cells
- G01N27/327—Biochemical electrodes, e.g. electrical or mechanical details for in vitro measurements
- G01N27/3271—Amperometric enzyme electrodes for analytes in body fluids, e.g. glucose in blood
- G01N27/3273—Devices therefor, e.g. test element readers, circuitry
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- G01—MEASURING; TESTING
- G01K—MEASURING TEMPERATURE; MEASURING QUANTITY OF HEAT; THERMALLY-SENSITIVE ELEMENTS NOT OTHERWISE PROVIDED FOR
- G01K7/00—Measuring temperature based on the use of electric or magnetic elements directly sensitive to heat ; Power supply therefor, e.g. using thermoelectric elements
- G01K7/16—Measuring temperature based on the use of electric or magnetic elements directly sensitive to heat ; Power supply therefor, e.g. using thermoelectric elements using resistive elements
- G01K7/22—Measuring temperature based on the use of electric or magnetic elements directly sensitive to heat ; Power supply therefor, e.g. using thermoelectric elements using resistive elements the element being a non-linear resistance, e.g. thermistor
- G01K7/24—Measuring temperature based on the use of electric or magnetic elements directly sensitive to heat ; Power supply therefor, e.g. using thermoelectric elements using resistive elements the element being a non-linear resistance, e.g. thermistor in a specially-adapted circuit, e.g. bridge circuit
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Abstract
The invention belongs to the technical field of electronics, and discloses a medical smart phone system and an implementation method thereof. The medical detection circuit is combined together through a communication bus of a main board of the smart phone, the medical detection circuit collects the environment temperature detection data, the detection result data and the test paper type 3 data, the smart phone collects the data and eliminates the environment interference, and accurate and reliable medical detection data are obtained after the equipment interference. Thereby realizing a smartphone system for medical use.
Description
Technical Field
The invention belongs to the technical field of electrochemistry, and particularly relates to a system implementation method for a medical smart phone.
Background
At present, a portable electrochemical detection instrument can detect multiple indexes and has wide market foundation. Meanwhile, the popularity of the smart phone is very high. The electrochemical detection instrument is integrated into the smart phone, so that the practicability is high. The intelligent mobile phone body index detection method has the advantages that users can detect body indexes of the users conveniently, and after detection data are obtained, the intelligent mobile phone can be used for communication and calculation. And the storage function provides various help for the subsequent medical service of the user.
However, since the electrochemical detection has a very high requirement for temperature detection, the current detection value can be accurately calculated only by knowing the environmental temperature accurately. The simple integration of the electrochemical detection instrument into the handset is inevitably affected by the temperature of the handset and is also unpredictable. This will greatly disturb the detection result and thus lose the detection significance.
In addition, the mobile phone is an electromagnetic emitter, which has considerable interference on precise electrochemical detection, so that perfect electromagnetic shielding needs to be made on an electrochemical detection circuit part, and detection in the process of mobile phone conversation or answering is avoided through communication protocols of the two parts.
Finally, because the mobile phone is a high-density, light and thin electronic product, higher requirements are put on the miniaturization of the sensor connection design and the circuit design on the mobile phone.
In summary, after the electrochemical detection instrument is integrated into a mobile phone, the problems of temperature sensor, electromagnetic shielding, design miniaturization and detection interference need to be solved.
Disclosure of Invention
In order to overcome the problems in the background art, the invention provides a medical smart phone system and an implementation method thereof, which solve the problems of temperature and electromagnetic interference on an electrochemical detection circuit integrated in a smart phone through the design of a medical sensor, a medical detection circuit and a smart phone master control, and enable the medical smart phone system to have real practicability.
The invention adopts the following technical scheme:
a medical smart phone system implementation method comprises the steps that after a medical sensor is inserted into a medical sensor connector, a medical detection circuit firstly identifies the type of the medical sensor, and collects the temperature on the medical sensor to obtain the room temperature.
The medical detection circuit reads the reading of the detection index, collects the room temperature data detected by the system temperature sensor, corrects the calculated value, sends the calculated value to the smart phone main control, and displays the detection result to the user through the special app of the smart phone.
The medical sensor connector of the medical sensor identifies the type of the sensor by the short-circuit position of the metal electrode of the medical sensor.
And sending the data to the master control of the smart phone through a bus communication protocol, and allowing the app to display and transmit the data.
A medical smart phone system comprises a smart phone master control, a medical detection circuit, a shielding case, a medical sensor connector, a system temperature sensor and a medical sensor/room temperature sensor.
The smart phone master control realizes communication with the medical detection circuit through a bus communication protocol and supports app to display and transmit data.
The medical detection circuit communicates with the medical sensor through the medical sensor connector and also communicates with a system temperature sensor provided in the handset for measuring the temperature within the handset.
The further technical scheme is that the medical sensor connector is internally contacted with the medical sensor by adopting a carbon sheet.
The further technical scheme is that the medical sensor connector adopts phosphor copper.
The further technical scheme is that the shielding case wraps the outside of the medical detection circuit.
The medical temperature sensor can change different resistance values according to different temperatures.
The medical sensor is a sensor combining an electrochemical sensor and a temperature sensor.
The medical sensor is an enzyme which is sensitive to a reactant and is arranged on a metal electrode, and after the instrument provides reaction voltage, reaction current with equal proportion is obtained, so that the measured index concentration is calculated.
The temperature sensor is fixed on the integral base plate of the medical sensor by a patch temperature-sensitive resistor in a laser welding mode and is connected to a contact (temperature measuring electrode) of the medical sensor through an internal lead.
The invention has the beneficial effects that:
according to the invention, through the design of the medical sensor, the medical detection circuit and the smart phone master control, the problems of temperature and electromagnetic interference on the smart phone after the electrochemical detection circuit is integrated in the smart phone are solved, and the medical smart phone system has real practicability.
Drawings
Fig. 1 is a schematic structural diagram of a medical smartphone system implementation provided in an embodiment of the present invention;
FIG. 2 is a schematic view of a substrate layer of a triglyceride test strip with a temperature tag;
FIG. 3 is a schematic view of an electrochemical metal electrode layer;
FIG. 4 is a schematic view of a cover layer;
FIG. 5 is a schematic representation of a lipoprotein lipase layer;
FIG. 6 is a schematic view of an upper spacer layer;
in fig. 1, 100-smartphone master, 101-medical detection circuit, 102-shield, 103-medical sensor connector, 104-system temperature sensor, 105-medical sensor/room temperature sensor.
Note: the medical sensor is a consumable, and is intelligently used once in actual use.
1. A triglyceride test paper substrate layer with a temperature label;
2. an electrochemical metal electrode layer;
2-1, an electrochemical working electrode;
2-2, an electrochemical counter electrode;
2-3, starting up to switch on the electrode;
2-4, triggering electrodes when full blood exists;
2-5, temperature measuring electrodes;
2-6, a temperature sensor;
3. a cover layer is arranged on the outer surface of the substrate,
3-1, a septum layer;
3-2, a reaction zone;
4. a lipoprotein lipase layer;
5. an upper interlayer;
5-1, an upper cover plate;
5-2 and pores.
Detailed Description
In order to make the objects, technical solutions and advantages of the present invention more apparent, the technical solutions of the present invention are described below clearly and completely, and it is obvious that the described embodiments are some, not all embodiments of the present invention. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
As shown in fig. 1, a medical smartphone system includes a smartphone master 100, medical detection circuitry 101, a shield 102, a medical sensor connector 103, a system temperature sensor 104, a medical sensor/room temperature sensor 105.
The smart phone master control 100 is in communication with the medical detection circuit 101 through a bus communication protocol, and supports app to display and transmit data.
The medical detection circuit 101 communicates with a medical sensor 105 through a medical sensor connector 103 and also communicates with a system temperature sensor 104 provided in the handset for measuring the temperature within the handset.
The medical sensor 105 is formed by sequentially attaching a test paper substrate layer with a temperature label, an electrochemical metal electrode layer 2, a covering layer 3 and an upper interlayer 5 from bottom to top, wherein the electrochemical metal electrode layer 2 consists of an electrochemical working electrode 2-1, an electrochemical counter electrode 2-2, a starting switch-on electrode 2-3, a full blood trigger electrode 2-4, a temperature measuring electrode 2-5 and a metal electrode of a temperature sensor 2-6; the covering layer 3 is composed of a septum 3-1 and a reaction region 3-2, and the specific enzyme is arranged in the reaction region 3-2 of the covering layer 3;
according to the distance from the top end of the blood sucking end, an electrochemical working electrode 2-1, an electrochemical counter electrode 2-2, a temperature sensor 2-6, a full blood trigger electrode 2-4, a start-up switch-on electrode 2-3 and a temperature measuring electrode 2-5 are sequentially arranged from near to far, the electrochemical working electrode 2-1 is independently arranged on the left side of the start-up switch-on electrode 2-3, the electrochemical working electrode 2-1 and the electrochemical counter electrode 2-2 are used for measuring characteristic current, the start-up switch-on electrode 2-3 is connected with the full blood trigger electrode 2-4, the start-up switch-on electrode 2-3 and the full blood trigger electrode 2-4 are positioned between the electrochemical working electrode 2-1 and the electrochemical counter electrode 2-2, and the start-up switch-on electrode 2-3 is positioned on the left side of the full blood trigger electrode 2, the right side of the electrochemical counter electrode 2-2 is provided with a temperature measuring electrode 2-5, the electrochemical counter electrode 2-2 is connected with the temperature measuring electrode 2-5 through a temperature sensor 2-6, and the temperature measuring electrode 2-5 is used for measuring the resistance value of the temperature sensor 2-6.
The further technical solution is that the medical sensor connector 103 is made of phosphor copper material.
Further, a shielding case 102 is arranged outside the medical detection circuit 101, the shielding case 102 is made of pure copper galvanized materials, the shielding effectiveness reaches the A-level standard, and radiation emitted by the smart phone is blocked.
Further technical solution is that the medical sensor connector 105 is connected with the medical sensor 105 by using a carbon sheet.
An implementation method of a medical smart phone system comprises the following steps:
step 2, after the medical detection circuit 101 is connected with a high-precision resistor again, the medical detection circuit 101 is sent with driving voltage again, the temperature sensors 2-6 on the medical sensor 105 can change different resistance values according to the temperature, and corresponding signals are collected through the DAC;
and 3, substituting the temperature obtained by the two measurements into a fitting formula written in advance inside, and obtaining the concentration of the measured object through fitting operation
The medical detection circuit 101 reads the reading of the detection index, summarizes the room temperature data detected by the system temperature sensor 104, corrects the value and sends the corrected value to the smart phone master control 100, and the detection result is displayed to the user through the special app of the smart phone;
if the temperature detected by the system temperature sensor 104 (as a correction of the internal temperature) exceeds a set value, the medical detection circuit 101 will send an over-temperature alarm to the smartphone master control 100 via the communication protocol, and cancel the current measurement.
After the medical sensor 105 is successfully driven, the medical detection circuit 101 receives signals of the medical sensor 105, which are a uA-level current analog signal and an mv-level voltage signal, wherein the uA-level current analog signal is generated by a specific enzyme reacting with a specific substance in blood, and the mv-level voltage signal is output by a temperature sensor 2-6 on the medical sensor 105 for measurement, and for the current signal, the current signal is first converted into a voltage through a current-voltage conversion circuit, and then amplified through a precision operational amplifier. After the voltage signal enters, the voltage signal is directly amplified through a precision operational amplifier, 2 paths of analog voltage are formed inside, the analog signal is output, analog and digital switching is carried out through a DAC circuit, and the analog signal is used as the basis of subsequent calculation processing.
The further technical scheme is that the measurement result is sent to the smart phone master control 100 according to the bus protocol IIC/TLL 2 after CRC check;
if the smart phone master control 100 obtains the data, the decoding operation of the CRC is performed to check whether the transmitted data is complete, and if an error is found, a retransmission request is initiated.
A further technical solution is that the smart phone master control 100 buffers the current data until the transmission is successful before receiving no signal confirming that the data is successfully received.
The temperature sensor (temperature sensitive resistance wires 2-6Rin) on the medical sensor 105 provided by the embodiment of the invention can test the real environment temperature of the test paper. Therefore, the reaction result is compensated in the intelligent medical mobile phone according to the electrochemical temperature compensation principle, and the concentration of the target substance is finally measured.
The medical sensor 105 is connected with the medical detection circuit 101 through the medical sensor connector 103, a carbon sheet is adopted in the medical sensor connector 103 to be in contact with the medical sensor 103, and the material is phosphorus and copper with good electrical performance and mechanical performance.
After the medical sensor 105 and the medical detection circuit 101 are connected together, the medical detection circuit 101 outputs an electrochemical reaction driving voltage at an electrochemical reaction pin (the electrochemical working electrode 2-1 and the electrochemical counter electrode 2-2), the driving voltage is output by a DAC, and the DAC parameters are set through software, so that the required voltage can be generated.
The temperature sensor 2-6 outputs fixed voltage after being connected with a precision resistor in series through the medical detection circuit 101, the temperature sensor 2-6 can change different resistance values according to different temperatures, and temperature signal measurement values are led out by the temperature measurement electrodes 2-5.
After the voltage is successfully driven, the reaction data of the medical sensor 105 is a current analog signal of a muA level, the temperature sensor 2-6 is a voltage signal of an mv level, and after the voltage signal enters the medical detection circuit 101, the medical sensor is divided into 2 paths for respective processing. For the current signal, the current signal is firstly converted into voltage through a current-voltage conversion circuit and then amplified through a precise operational amplifier. After the voltage signal enters, the voltage signal is directly amplified through a precision operational amplifier, and 2 paths of analog voltage output are formed inside the voltage signal.
In addition, external accurate temperature correction avoids large heating amount of the smart phone master control 100 during charging and high-speed operation, the medical detection circuit 101 is also internally provided with a system temperature sensor 104 as temperature control of an internal circuit, when the internal temperature is too high, accuracy of a detection result is affected, an over-temperature alarm is sent to the smart phone master control 100 through a communication protocol, and current measurement is cancelled.
The analog signal is converted from analog to digital by an ADC circuit of the medical detection circuit 101, and used as a basis for subsequent calculation processing. The medical detection circuit 101 brings the measurement value of the medical sensor 105 and the measurement value of the system temperature sensor 104 on the medical detection circuit 104 into a fitting formula written in advance inside according to the read digital signal, and obtains the concentration of the measured object through fitting operation.
The measurement result is transmitted according to the IIC/TLL 2 modes of the bus protocol, so that the maximum hardware compatibility is ensured. And adding CRC (cyclic redundancy check) to the data content, performing CRC decoding operation after the smart phone master control 100 obtains the data, checking whether the transmitted data is complete, and initiating a retransmission request when errors are found. And the detection end buffers the current data until the transmission is successful before the detection end does not receive the signal of successful data receiving confirmation. This mechanism ensures that no transmission errors occur in the event of data reception that is accidentally interfered.
The shielding case 102 is wrapped outside the medical detection circuit 101, pure copper zinc plating materials are adopted for the shielding case 102, the thickness is designed to be 0.5mm, the shielding effectiveness reaches the A-level standard, and radiation emitted by the smart phone main control 100 is blocked.
The overall circuit design size is the size of a standard SIM card socket, so that the integrated circuit is convenient to integrate in a smart phone, and the appearance is not influenced.
Example 1
As shown in fig. 2 to 6, the medical sensor provided by the embodiment of the present invention includes: the test paper comprises a triglyceride test paper substrate layer 1 with a temperature label, an electrochemical metal electrode layer 2, a covering layer 3, a lipoprotein lipase layer 4 and an upper interlayer 5.
The medical sensor is formed by sequentially attaching a substrate layer 1 with a temperature identification test paper, an electrochemical metal electrode layer 2, a middle layer 3, a lipoprotein lipase layer 4 and an upper middle layer 5 from bottom to top.
The electrochemical metal electrode layer 2 comprises an electrochemical working electrode 2-1, an electrochemical counter electrode 2-2, a power-on switch-on electrode 2-3, a full blood trigger electrode 2-4, a temperature measuring electrode 2-5 and a temperature sensor 2-6, and the electrochemical metal electrode layer 2 is a metal electrode.
Preferably, the triglyceride test paper substrate layer 1 with the temperature label is made of any one of polyethylene terephthalate, polyvinyl chloride and polypropylene.
Preferably, the electrochemical metal electrode layer 2 consists of an electrochemical working electrode 2-1, an electrochemical counter electrode 2-2, a power-on switch-on electrode 2-3, a full blood trigger electrode 2-4, a temperature measuring electrode 2-5 and metal electrodes in the areas of temperature sensors 2-6.
And according to the distance from the top end of the blood sucking end, the electrochemical working electrode 2-1, the electrochemical counter electrode 2-2, the temperature sensor 2-6, the full blood triggering electrode 2-4, the starting switch-on electrode 2-3 and the temperature measuring electrode 2-5 are arranged in sequence from near to far, and the temperature sensor 2-6 is a thermosensitive metal wire.
The electrochemical working electrode 2-1 and the electrochemical counter electrode 2-2 are used for measuring characteristic current and are independently arranged on the left side of the start-up connection electrode 2-3, the start-up connection electrode 2-3 is connected with the full blood trigger electrode 2-4, the start-up connection electrode 2-3 can act when the test paper is inserted in the start-up device, and the indicator for indicating blood drop measurement is prompted on the instrument; the 2-4 full blood trigger electrode has the function of prompting that the blood adding amount is insufficient, and the dropping blood amount is enough to accurately test, the insufficient full blood trigger electrode 2-4 is triggered to prompt that the sample adding amount is insufficient, and the starting-up switch-on electrode 2-3 and the full blood trigger electrode 2-4 are positioned between the electrochemical working electrode 2-1 and the electrochemical counter electrode 2-2, and the starting-up switch-on electrode 2-3 is positioned at the left side of the full blood trigger electrode 2-4, the right side of the electrochemical counter electrode 2-2 is provided with a temperature measuring electrode 2-5, the electrochemical counter electrode 2-2 is connected with the temperature measuring electrode 2-5 through the temperature sensor 2-6, and the temperature measuring electrode 2-5 is used for measuring the resistance value of the temperature sensor 2-6, so that the temperature of the reaction area 3-2 is obtained.
Preferably, the upper isolation layer 5 consists of an upper cover plate 5-1 and air holes 5-2, and the upper end of the upper cover plate 5-1 is provided with the air holes 5-2.
The invention relates to a preparation process of electrochemical triglyceride test paper with a temperature label, which comprises the following steps:
step 2, dropping the prepared medicine liquid into a corresponding area;
step 3, adhering a middle partition hydrophilic membrane after baking;
and 4, cutting into small strips and packaging into a barrel.
The principle of this reaction is as follows:
H2O2+Fe2+——→H2O+Fe3+
the use method of the medical sensor comprises the following steps:
firstly, a blood sucking port of the test paper is close to fresh fingertip blood, the blood is sucked into the reaction area 3-2 by the test paper and is filled in the reaction area 3-2, and the test paper is subjected to electrochemical reaction with the blood through lipoprotein lipase fixed on an electrochemical working electrode 2-1.
And secondly, measuring the concentration of the triglyceride by using a triglyceride detector through characteristic current collected by the electrochemical working electrode 2-1 and utilizing a standard corresponding curve function of the concentration and the current.
And thirdly, measuring the temperature of a reaction area for temperature compensation calibration due to the electrochemical enzyme method. The temperature of the reaction zone is measured by a temperature sensor located closer to the zone.
The temperature measured by the temperature sensor can be determined by measuring the resistance of the temperature sensor, so that the temperature estimation of a reaction area is determined, a preset temperature compensation curve is called from a corresponding medical mobile phone, the temperature compensation is carried out on the measured electrochemical current, and the concentration of the electrochemical triglyceride in blood is analyzed and measured by using a measured concentration standard curve library.
The application of the principles of the present invention will be further described with reference to the accompanying drawings in which:
temperature labeled triglyceride test paper substrate layer 1: is made of any one of polyethylene terephthalate (PET), polyvinyl chloride (PVC) and polypropylene (PP).
Electrochemical metal electrode layer 2: for example, the electrochemical working electrode 2-1, the electrochemical counter electrode 2-2, the power-on electrode 2-3 and the full blood trigger electrode 2-4 can all adopt noble metals. The temperature sensors 2-6 are made of temperature-sensitive resistance materials. The temperature sensors 2-6 are made by adopting a temperature-sensitive resistance material (gold, platinum and copper) magnetron sputtering coating process.
The electrochemical working electrode 2-1 and the electrochemical counter electrode 2-2 measure triglyceride in blood in the reaction area 3-2, temperature compensation correction is carried out through temperature results measured by the temperature sensor 2-6, and finally triglyceride concentration measurement values are displayed on corresponding intelligent terminals such as medical mobile phones or medical pads.
The full blood trigger electrode 2-4 is positioned at the lowest end of the reaction area 3-2, when blood enters from the blood sucking port, the full blood trigger electrode 2-4 at the bottom of the reaction area 3-2 is required to reach the test paper to send a measurement countdown to a corresponding medical mobile phone or medical pad, an intelligent medical terminal (medical intelligent mobile phone) starts the countdown test, and the design of the full blood trigger electrode 2-4 can avoid the inaccuracy of a measurement value caused by the fact that the whole reaction area 3-2 is not filled with the blood; one of the power-on switch-on electrodes 2-3 is connected with two ends of an interrupt circuit in the intelligent medical terminal after the test paper is inserted into the corresponding intelligent medical terminal, so that the test paper circuit and the circuit of the intelligent medical terminal form a complete circuit, the intelligent medical terminal is automatically powered on, the test paper is taken out after measurement is completed, and the intelligent medical terminal is automatically powered off.
The impedance of the reaction area temperature sensors 2-6 is determined by the temperature, and different impedances are corresponded according to different reaction temperatures; lipoprotein lipase 4 provides an oxidase that undergoes an electrochemical reaction.
An upper cover 5-1 for covering the reaction area 3-2, the front end of the upper cover 5-1 having an air hole 5-2 for discharging air when blood enters the reaction area 3-2.
The upper cover plate 5 is positioned at the upper end of the middle partition layer 3-1 and is used for protecting the reaction area 3-2 from being interfered by the external environment.
Practical embodiments of the invention
Experimental equipment: triglyceride detector module, quality control liquid with different concentration gradients, and liquid transfer gun
Meanwhile, a part of test paper is randomly extracted from the traditional triglyceride test paper and the triglyceride test paper of the invention respectively, 5 triglycerides with gradient are selected as the concentration of the quality control liquid, 5-10 test paper are tested for each concentration, the temperature of the tested external environment is 23 ℃, the average value of the concentration values of the measured triglycerides is taken as the measured value of the concentration of the quality control, and the test results of the two are compared, wherein the test results are shown in the following table:
TABLE 1 results of the test on the triglyceride test paper of the present invention (unit: mmol/L)
TABLE 2 test results of conventional triglyceride test paper (unit: mmol/L)
Finally, the comparison of the test results of the triglyceride testing and the testing reaction area for automatic temperature compensation is known to be more accurate than the test result of the traditional triglyceride test paper for detecting the environmental temperature, and the deviation of the test result from the biochemical value of TG is small.
The temperature has a great influence on the test result, the traditional test paper is the test environment temperature and is not the temperature of the reaction area, if the temperature of the instrument is counted again, the temperature of the reaction area is different from the environment temperature, the final test result has larger deviation even through temperature compensation, and an independent temperature compensation electronic card is required to be inserted into an intelligent terminal in advance to tell the machine to measure the environment temperature, so the measurement cost is greatly increased.
The test paper is additionally provided with a temperature sensor between the electrochemical electrode pair and the rightmost electrode, so that the triglyceride test paper has the capability of measuring the temperature near the reaction region, and the temperature measured by the triglyceride test paper is fed back to the intelligent terminal, so that accurate temperature compensation is performed, and the triglyceride measurement result is more accurate.
The temperature sensor is used for measuring the temperature of the test paper chemical reaction area, but not the ambient temperature, because the original intelligent terminal is used for measuring the ambient temperature, the difference between the temperature of the reaction area and the ambient temperature is large due to the fact that the instrument generates heat and the heat released by chemical reaction possibly causes inaccurate temperature compensation, the temperature of the reaction area is measured in real time, the temperature compensation is accurate, the measurement result is accurate, the temperature sensor is required to be located at the specific position, and the temperature of the reaction area cannot be measured at other places.
Finally, it should be noted that: the above examples are only intended to illustrate the technical solution of the present invention, but not to limit it; although the present invention has been described in detail with reference to the foregoing embodiments, it will be understood by those of ordinary skill in the art that: the technical solutions described in the foregoing embodiments may still be modified, or some technical features may be equivalently replaced; and such modifications or substitutions do not depart from the spirit and scope of the corresponding technical solutions of the embodiments of the present invention.
Claims (7)
1. A method for realizing a medical smart phone system is characterized by comprising the following steps:
step 1, connecting a medical sensor with a medical sensor connector, firstly identifying the type of the medical sensor by a medical detection circuit, outputting a driving voltage by an internal DAC (digital-to-analog converter) by the medical detection circuit, generating output voltages at an electrochemical working electrode and an electrochemical counter electrode of the medical sensor by the driving voltage, and acquiring a room temperature after the medical detection circuit acquires the voltage on the medical sensor;
step 2, after the medical detection circuit is connected with a high-precision resistor, the medical detection circuit sends driving voltage to the medical detection circuit again, a temperature sensor on the medical sensor can change different resistance values according to temperature, and the medical detection circuit acquires corresponding signals through a DAC;
step 3, substituting the temperature obtained by the two-time measurement into a fitting formula written in advance inside, obtaining the concentration of the measured object through fitting operation, reading the reading of the detection index by the medical detection circuit, summarizing the room temperature data detected by the system temperature sensor, sending the room temperature data to the smart phone master control after correcting the value, and displaying the detection result to the user through the special mobile phone app;
at the moment, if the temperature detected by the system temperature sensor exceeds a set value, the medical detection circuit sends out an overtemperature alarm to the main control through a communication protocol and cancels the current measurement;
the medical smart phone system comprises a smart phone master control, a medical detection circuit, a medical sensor connector, a system temperature sensor and a medical sensor, wherein the smart phone master control is communicated with the medical detection circuit through a bus communication protocol and supports app to display and transmit data;
the medical sensor is formed by sequentially attaching a test paper substrate layer with a temperature label, an electrochemical metal electrode layer, a covering layer and an upper interlayer from bottom to top, wherein the electrochemical metal electrode layer consists of an electrochemical working electrode, an electrochemical counter electrode, a starting-up switch-on electrode, a full-blood trigger electrode, a temperature measuring electrode and a metal electrode of the temperature sensor; the covering layer consists of a septum and a reaction area, and the specific enzyme is arranged in the reaction area of the covering layer;
according to the distance from the top end of the blood sucking end, an electrochemical working electrode, an electrochemical counter electrode, a temperature sensor, a full blood trigger electrode, a starting connection electrode and a temperature measuring electrode are sequentially arranged from near to far, the electrochemical working electrode is independently arranged on the left side of the starting connection electrode, the electrochemical working electrode and the electrochemical counter electrode are used for measuring characteristic current, the starting connection electrode is connected with the full blood trigger electrode, the starting connection electrode and the full blood trigger electrode are located between the electrochemical working electrode and the electrochemical counter electrode, the starting connection electrode is located on the left side of the full blood trigger electrode, the right side of the electrochemical counter electrode is provided with the temperature measuring electrode, the electrochemical counter electrode is connected with the temperature measuring electrode through the temperature sensor, and the temperature measuring electrode is used for measuring the resistance value of the temperature sensor.
2. The method of claim 1, wherein the medical sensor connector is made of phosphor copper.
3. The method of claim 1, wherein a shield is disposed outside the medical detection circuit, and the shield is made of pure copper-plated zinc.
4. The method of claim 1, wherein the medical sensor connector is connected to the medical sensor by a carbon plate.
5. The method of claim 1, wherein in step 1 or step 2, the medical sensor signals received by the medical detection circuit are a uA-level current analog signal and an mv-level voltage signal, wherein the uA-level current analog signal is generated by a specific enzyme reacting with a specific substance in blood, and the mv-level voltage signal is output by a temperature sensor on the medical sensor, and for the current signal, the current signal is first converted into a voltage by a current-voltage conversion circuit and then amplified by a precision operational amplifier; after the voltage signal enters, the voltage signal is directly amplified through a precision operational amplifier, 2 paths of analog voltage are formed inside, the analog signal is output, analog and digital switching is carried out through a DAC circuit, and the analog signal is used as the basis of subsequent calculation processing.
6. The method for implementing a medical smart phone system according to claim 1, wherein in step 3, the measurement result is sent to the smart phone master control after being subjected to CRC check according to a bus protocol IIC/TLL 2;
if the smart phone master control obtains the data, the decoding operation of the CRC is carried out, whether the transmitted data is complete or not is checked, and if errors are found, a retransmission request is initiated.
7. The method as claimed in claim 1, wherein in step 3, before the smart phone master control receives no confirmation data receiving success signal, the medical detection circuit buffers the current data until the transmission is successful.
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Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103196960A (en) * | 2013-03-13 | 2013-07-10 | 北京怡成生物电子技术有限公司 | Blood glucose testing device and system |
| CN103235024A (en) * | 2013-04-24 | 2013-08-07 | 天津时代怡诺科技有限公司 | Mobile phone system for testing blood sugar, and testing method thereof |
| CN105527329A (en) * | 2015-12-29 | 2016-04-27 | 东莞市青麦田数码科技有限公司 | Smartphone-based human chorionic gonadotropin detecting device |
| CN106770526A (en) * | 2017-01-11 | 2017-05-31 | 朱斌 | A kind of blood sugar test method |
| CN206756848U (en) * | 2017-05-24 | 2017-12-15 | 牟万容 | A kind of high blood glucose monitoring system of precision |
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| US10883995B2 (en) * | 2017-03-28 | 2021-01-05 | Faizan Ahmed | Methods and systems for managing the temperature of medicines |
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Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103196960A (en) * | 2013-03-13 | 2013-07-10 | 北京怡成生物电子技术有限公司 | Blood glucose testing device and system |
| CN103235024A (en) * | 2013-04-24 | 2013-08-07 | 天津时代怡诺科技有限公司 | Mobile phone system for testing blood sugar, and testing method thereof |
| CN105527329A (en) * | 2015-12-29 | 2016-04-27 | 东莞市青麦田数码科技有限公司 | Smartphone-based human chorionic gonadotropin detecting device |
| CN106770526A (en) * | 2017-01-11 | 2017-05-31 | 朱斌 | A kind of blood sugar test method |
| CN206756848U (en) * | 2017-05-24 | 2017-12-15 | 牟万容 | A kind of high blood glucose monitoring system of precision |
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