CN111388601A - Preparation process of dendrobium huoshanense throat-soothing buccal tablets - Google Patents

Preparation process of dendrobium huoshanense throat-soothing buccal tablets Download PDF

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CN111388601A
CN111388601A CN202010266674.1A CN202010266674A CN111388601A CN 111388601 A CN111388601 A CN 111388601A CN 202010266674 A CN202010266674 A CN 202010266674A CN 111388601 A CN111388601 A CN 111388601A
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screw
fixed
rotating pipe
stirring
parts
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何斌
何子文
何凯文
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Anhui Huoshan County Yaowanggu Forest & Agricultural Science & Technology Co ltd
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Anhui Huoshan County Yaowanggu Forest & Agricultural Science & Technology Co ltd
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Publication of CN111388601A publication Critical patent/CN111388601A/en
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/88Liliopsida (monocotyledons)
    • A61K36/898Orchidaceae (Orchid family)
    • A61K36/8984Dendrobium
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7016Disaccharides, e.g. lactose, lactulose
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56Materials from animals other than mammals
    • A61K35/63Arthropods
    • A61K35/64Insects, e.g. bees, wasps or fleas
    • A61K35/644Beeswax; Propolis; Royal jelly; Honey
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/34Campanulaceae (Bellflower family)
    • A61K36/346Platycodon
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/53Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/534Mentha (mint)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/75Rutaceae (Rue family)
    • A61K36/752Citrus, e.g. lime, orange or lemon
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/88Liliopsida (monocotyledons)
    • A61K36/896Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
    • A61K36/8968Ophiopogon (Lilyturf)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0053Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/0056Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/04Drugs for disorders of the respiratory system for throat disorders
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01FMIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F27/00Mixers with rotary stirring devices in fixed receptacles; Kneaders
    • B01F27/80Mixers with rotary stirring devices in fixed receptacles; Kneaders with stirrers rotating about a substantially vertical axis
    • B01F27/90Mixers with rotary stirring devices in fixed receptacles; Kneaders with stirrers rotating about a substantially vertical axis with paddles or arms 
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01FMIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F35/00Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
    • B01F35/90Heating or cooling systems
    • B01F35/95Heating or cooling systems using heated or cooled stirrers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30Extraction of the material
    • A61K2236/31Extraction of the material involving untreated material, e.g. fruit juice or sap obtained from fresh plants
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01FMIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F35/00Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
    • B01F35/90Heating or cooling systems
    • B01F2035/99Heating
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01FMIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F2101/00Mixing characterised by the nature of the mixed materials or by the application field
    • B01F2101/22Mixing of ingredients for pharmaceutical or medical compositions

Abstract

The invention discloses a preparation process of dendrobium huoshanense throat-benefiting buccal tablets, which are prepared from the following raw materials in parts by weight: 20-30 parts of dendrobium huoshanense, 15-20 parts of radix ophiopogonis, 8-10 parts of platycodon grandiflorum, 5-8 parts of exocarpium citri grandis, 5-8 parts of mint, 5-8 parts of sweet leaves, 10-15 parts of honey and 10-15 parts of maltose; this sore-throat relieving buccal tablet, effectual cure throat inflammation, mucosa congestion, mucosa edema, throat wall lymph follicle hyperplasia, the adnexed symptom of secretion, a decocting device has been used at the in-process of preparing the dendrobium huoshanense sore-throat relieving buccal tablet simultaneously, this decocting device smashes bold maltose, the system efficiency of stewing of maltose has been promoted, the effectual vortex flow that produces of having prevented system in-process of stewing, equipment life has been increased, and collect the system of stewing through receiving the magazine, make the volume of system of stewing can not be too big, make things convenient for the use of follow-up technology, further promoted the preparation efficiency of dendrobium huoshanense sore-throat relieving buccal tablet.

Description

Preparation process of dendrobium huoshanense throat-soothing buccal tablets
Technical Field
The invention belongs to the field of buccal tablet preparation, and particularly relates to a preparation process of dendrobium huoshanense buccal tablets capable of relieving sore throat.
Background
Pharyngitis is mainly divided into acute pharyngitis, chronic pharyngitis and atrophic pharyngitis, the acute pharyngitis is acute inflammation of pharyngeal mucosa, submucosal tissues and lymphatic tissues, is part of upper respiratory tract infection, can occur independently, can be secondary to acute rhinitis, is mostly generated in the crossing of autumn, winter and spring, the chronic pharyngitis is chronic inflammation of pharyngeal mucosa, submucosa and lymphatic tissues, is part of upper respiratory tract chronic inflammation, is often seen in adults, has long course of disease, has stubborn symptoms, is not easy to cure, and is relieved and cured by a common sore throat buccal tablet;
chinese patent CN105012360A discloses a throat-clearing and moistening buccal tablet, which comprises, by mass, 10-15% of semen arecae extract, 5-15% of food binder, 57-77% of filler, 3-5% of menthol, 3-5% of borneol and 2-3% of distilled water; the throat clearing and moistening buccal tablet has the effects of cooling, resisting inflammation, moistening lung, relieving cough and increasing oral humidity, can effectively relieve dry mouth and tongue caused by smoking, and achieves the purposes of clearing and moistening throat, but the throat clearing and moistening buccal tablet cannot cure symptoms of throat inflammation, mucosal congestion, mucosal edema, pharyngeal wall lymph follicular hyperplasia and secretion attachment.
Disclosure of Invention
The invention aims to provide a preparation process of dendrobium huoshanense throat-benefiting buccal tablets.
The technical problems to be solved by the invention are as follows:
1. most of common sore throat relieving buccal tablets in the market at present can only relieve discomfort of the throat, can not cure symptoms of inflammation of the throat, congestion of mucous membranes, edema of mucous membranes, lymphofollicular hyperplasia of throat walls and secretion attachment, and can not achieve the effect of removing halitosis;
2. the decocting device can be used in the preparation process of the sore-throat relieving buccal tablet, the traditional decocting device can accelerate the decocting of raw materials through stirring, but can generate a swirling flow in the stirring process, the swirling flow can enable the axial circulation speed to be lower than the radial circulation speed, the stirring effect is further influenced, the violently swirling liquid can cause the surge of reciprocating impulse, the effect of vortex is combined, impact force can be generated on equipment, and the service life of the equipment is further reduced.
3. Traditional system of stewing, after the raw materials system completion, need wait to system thing natural cooling, and natural cooling's efficiency is lower, and system thing can condense again after the cooling simultaneously, and this makes the system thing of stewing of preparing bulky, has influenced the subsequent use of system thing.
The purpose of the invention can be realized by the following technical scheme:
a preparation process of dendrobium huoshanense throat-benefiting buccal tablets comprises the following raw materials in parts by weight: 20-30 parts of dendrobium huoshanense, 15-20 parts of radix ophiopogonis, 8-10 parts of platycodon grandiflorum, 5-8 parts of exocarpium citri grandis, 5-8 parts of mint, 5-8 parts of sweet leaves, 10-15 parts of honey and 10-15 parts of maltose;
the dendrobium huoshanense buccal tablet for relieving sore throat is prepared by the following steps:
step S1: adding the dendrobium huoshanense into a pulping machine to prepare dendrobium huoshanense juice;
step S2: adding radix Ophiopogonis, radix Platycodi, exocarpium Citri Grandis, herba Menthae and folium Gaultheriae Yunnanensis into superfine pulverizer, pulverizing, sieving with 250-mesh and 300-mesh sieve, and mixing to obtain mixed powder;
step S3: the third motor is started to enable the first rotating shaft to rotate so as to drive the first screw and the first transmission gear, the first transmission gear drives the second transmission gear and the third transmission gear to rotate, the second transmission gear drives the second screw to rotate, the third transmission gear drives the third screw to rotate, honey and maltose are added into the stirring box body from the feeding hole, the first motor, the second motor and the heater are started, the heater raises the temperature inside the stirring box body to 125 ℃, the first motor drives the first rotating pipe to rotate, and then drives the first stirring blade to rotate clockwise at the rotating speed of 800-, stirring for 15-20min, introducing tap water into the cooling water tank from the water inlet until tap water flows out from the water outlet, opening valves in the first discharge port and the second discharge port, collecting the decoction from the first discharge port and the second discharge port, and cooling to room temperature to obtain decoction;
step S4: adding the decocted material obtained in the step S3 into an ultrafine grinder, grinding, sieving with a 100-mesh and 200-mesh sieve to obtain decocted material powder, uniformly stirring the mixed powder and the decocted material powder obtained in the step S1, and tabletting to obtain the dendrobium huoshanense throat-soothing buccal tablet.
Further, the boiling device of step S3, comprising a base, two support pillars oppositely disposed are fixed on the upper surface of the base, sliding grooves are formed on the side walls of the support pillars, a sliding rod is arranged inside the support pillars, a sleeve is sleeved on the sliding rod, the sleeve is slidably connected with the sliding rod, a top pipe is arranged on the lower surface of the sleeve, the top pipe is sleeved on the sliding rod, the top pipe is slidably connected with the sliding rod, the upper surface of the top pipe is attached to the lower surface of the sleeve, a spring is fixed on the lower surface of the top pipe, the spring is sleeved on the sliding rod, the bottom end of the spring is fixedly connected with the inner side wall of the support pillar, a connecting column is fixed on the side wall of the sleeve, the connecting column is matched with the sliding grooves on the side wall of the support pillars, a cooling water tank is further fixed on the upper surface of the base, a water inlet and a water outlet are, the side wall of the stirring box body is fixedly connected with the connecting column, a feed inlet is arranged at the top end of the stirring box body, a first discharge outlet and a second discharge outlet are arranged at the bottom end of the stirring box body, a first motor is fixed at the center of the top end of the stirring box body, a first rotating pipe is fixed on an output shaft extension of the first motor and is positioned inside the stirring box body, the first rotating pipe is rotatably connected with the stirring box body, a second rotating pipe and a third rotating pipe are sequentially arranged below the first rotating pipe, two first stirring blades which are oppositely arranged are respectively fixed on two sides of the first rotating pipe, the second rotating pipe and the third rotating pipe, stirring side plates are fixed on ends of the first stirring blades, a second motor is fixed at the bottom end of the stirring box body, a stirring shaft is fixed on an output shaft extension of the second motor and sequentially penetrates through the bottom wall of the stirring box body, the third rotating pipe, the second rotating pipe and the first rotating pipe, the stirring shaft is connected with the bottom wall of the, The third rotating pipe, the second rotating pipe and the first rotating pipe are connected in a rotating mode, a second stirring blade is fixed on the stirring shaft, the second stirring blade is located between the first rotating pipe and the second rotating pipe and between the second rotating pipe and the third rotating pipe, two opposite connecting rods are further fixed on the stirring shaft, a side bottom shovel plate is fixed at the end of each connecting rod, two opposite bottom shovel plates are fixed at the bottom end of the stirring shaft, and a heater is further fixed at the top end of the stirring box body.
Furthermore, the water inlet and the water outlet are positioned at two sides of the cooling tank, a material receiving partition plate is fixed inside the material receiving box, the material receiving partition plate and the bottom wall of the material receiving box are matched to form a storage tank, and a handle is fixed on the side wall of the material receiving box.
Furthermore, a first screw rod, a second screw rod and a third screw rod are arranged in the feed port, the first screw rod, the second screw rod and the third screw rod are arranged in a staggered mode, the first screw rod, the second screw rod and the third screw rod are matched, the first screw rod is positioned between the second screw rod and the third screw rod, the first screw rod is positioned below the second screw rod and the third screw rod, first rotating shafts are fixed at two ends of the first screw rod and are rotationally connected with the side wall of the feed port, a first transmission gear is fixed on each first rotating shaft, a second rotating shaft is fixed at two ends of the second screw rod and is rotationally connected with the side wall of the feed port, a second transmission gear is fixed on each second rotating shaft, a third rotating shaft is fixed at two ends of the third screw rod, a third transmission gear is fixed on each third rotating shaft, the first transmission gear, the second transmission gear and the third transmission gear are positioned outside the feed port, the first transmission gear is respectively meshed with the second transmission gear and the third transmission gear, the outside lateral wall of feed inlet is fixed with the backup pad, is fixed with the third motor in the backup pad, and the output shaft of third motor stretches and first drive gear fixed connection.
Further, the lateral wall that first rotary pipe was kept away from to the stirring curb plate be fixed with the lateral wall shovel board, the laminating of lateral wall shovel board and the inside lateral wall of agitator tank, the connecting rod is located the below of third rotary pipe, the laminating of side end shovel board and agitator tank inside lateral wall, the laminating of end shovel board and the inside diapire of agitator tank.
Further, the feeding port, the first discharging port and the second discharging port are internally provided with valves, the valve inside the first discharging port is located below the first screw, the first discharging port and the second discharging port are respectively located on two sides of the second motor, and the first discharging port and the second discharging port are located above the material collecting box.
The invention has the beneficial effects that: in the process of preparing the dendrobium huoshanense sore throat relieving buccal tablet, the radix ophiopogonis, the platycodon grandiflorum, the pummelo peel, the mint and the maltose are added, the radix ophiopogonis has the effects of promoting the production of body fluid, quenching thirst, moistening lung and arresting cough, the platycodon grandiflorum has the effects of arresting cough, eliminating phlegm, dispersing lung qi and expelling pus, the pummelo peel has the effects of dispelling cold, eliminating dampness, relieving qi and eliminating diseases, relieving cough, strengthening spleen and promoting digestion, the mint can treat sore throat and gum pain, the maltose can treat spleen and stomach qi deficiency, middle warmer deficiency cold, lung deficiency chronic cough and asthma, meanwhile, the mint and the sweet leaves have the effects of sterilizing, removing rot and refreshing breath, the dendrobium huoshanense is particularly suitable for people with asthenia, has the effects of health care and longevity, can effectively cure symptoms of throat inflammation, mucosal congestion, mucosal edema, pharyngeal wall lymphoid follicle hyperplasia and secretion attachment, and a decocting device is used in the preparation process of the dendrobium huoshanense sore throat relieving buccal tablet, this system device for stewing is through first screw rod, second screw rod, under the effect of third screw rod, smashes the bold maltose, has promoted the system efficiency of stewing of maltose, and first stirring vane and second stirring vane are stirred in the opposite direction, have effectually prevented to produce the vortex flow at system in-process of stewing, have increased equipment life, and the inside of material collecting box sets up the stock chest and makes the volume of mixture can not be too big, makes things convenient for the use of follow-up technology, has further promoted the preparation efficiency of hillstone dendrobium huoshanense sore throat buccal tablet.
Drawings
In order to more clearly illustrate the technical solutions of the embodiments of the present invention, the drawings used in the description of the embodiments will be briefly introduced below, and it is obvious that the drawings in the following description are only some embodiments of the present invention, and it is obvious for those skilled in the art that other drawings can be obtained according to the drawings without creative efforts.
FIG. 1 is a schematic structural view of a decocting device in a preparation process of the dendrobium huoshanense sore-throat relieving buccal tablet;
FIG. 2 is a schematic view of the structure A in FIG. 1;
FIG. 3 is a top view of a cooling water tank in the boiling device;
FIG. 4 is a top view of a material receiving box in the decocting device;
FIG. 5 is a schematic view of the structure B in FIG. 1;
FIG. 6 is a side view of a feed port in the decocting apparatus;
FIG. 7 is a schematic structural view of a first transmission gear, a second transmission gear and a third transmission gear in the decocting device;
FIG. 8 is a top view of a stirring side plate in the decocting apparatus;
FIG. 9 is a schematic view of structure C of FIG. 1;
fig. 10 is a bottom view of the stirring box in the decocting apparatus.
In the figure: 1. a base; 11. a support pillar; 12. a slide bar; 13. a sleeve; 14. jacking pipes; 15. a spring; 16. connecting columns; 2. a cooling water tank; 21. a water inlet; 22. a water outlet; 23. a cooling tank; 24. a material receiving box; 25. a material receiving clapboard; 26. a storage tank; 27. a handle; 3. a stirring box body; 31. a feed inlet; 311. a first screw; 3111. a first rotating shaft; 3112. a first drive gear; 312. a second screw; 3121. a second rotating shaft; 3122. a second transmission gear; 313. a third screw; 3131. a third rotating shaft; 3132. a third transmission gear; 314. a support plate; 315. a third motor; 32. a first discharge port; 33. a second discharge port; 34. a first motor; 341. a first rotary pipe; 342. a second rotary pipe; 343. a third rotary pipe; 344. a first stirring blade; 345. stirring the side plate; 346. a sidewall shovel plate; 35. a second motor; 351. a stirring shaft; 352. a second stirring blade; 353. a connecting rod; 354. a side sole shovel plate; 355. a bottom blade; 36. a heater.
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
Example 1
A dendrobium huoshanense buccal tablet for relieving sore throat is prepared from the following raw materials in parts by weight: 20 parts of dendrobium huoshanense, 15 parts of radix ophiopogonis, 8 parts of platycodon grandiflorum, 5 parts of exocarpium citri grandis, 5 parts of mint, 5 parts of sweet leaves, 10 parts of honey and 10 parts of maltose;
the dendrobium huoshanense buccal tablet for relieving sore throat is prepared by the following steps:
step S1: adding the dendrobium huoshanense into a pulping machine to prepare dendrobium huoshanense juice;
step S2: adding radix Ophiopogonis, radix Platycodi, exocarpium Citri Grandis, herba Menthae and folium Gaultheriae Yunnanensis into superfine pulverizer, pulverizing, sieving with 250 mesh sieve, and mixing to obtain mixed powder;
step S3: adding honey, maltose and the dendrobium huoshanense juice prepared in the step S1 into a decocting device, stirring for 15min at the rotation speed of 800r/min and the temperature of 120 ℃, and cooling to room temperature to prepare a decocted material;
step S4: adding the decoction obtained in the step S3 into a superfine pulverizer, pulverizing, sieving with a 100-mesh sieve to obtain decoction powder, uniformly stirring the mixed powder and the decoction powder obtained in the step S1, and tabletting to obtain the dendrobium huoshanense throat-soothing buccal tablets.
Example 2
A dendrobium huoshanense buccal tablet for relieving sore throat is prepared from the following raw materials in parts by weight: 25 parts of dendrobium huoshanense, 17.5 parts of dwarf lilyturf tuber, 9 parts of platycodon grandiflorum, 6.5 parts of pummelo peel, 6.5 parts of mint, 6.5 parts of sweet leaves, 12.5 parts of honey and 12.5 parts of maltose;
the dendrobium huoshanense buccal tablet for relieving sore throat is prepared by the following steps:
step S1: adding the dendrobium huoshanense into a pulping machine to prepare dendrobium huoshanense juice;
step S2: adding radix Ophiopogonis, radix Platycodi, exocarpium Citri Grandis, herba Menthae and folium Gaultheriae Yunnanensis into superfine pulverizer, pulverizing, sieving with 280 mesh sieve, and mixing to obtain mixed powder;
step S3: adding honey, maltose and the dendrobium huoshanense juice prepared in the step S1 into a decocting device, stirring for 18min at the rotation speed of 900r/min and the temperature of 123 ℃, and cooling to room temperature to prepare a decocted material;
step S4: adding the decoction obtained in the step S3 into a superfine pulverizer, pulverizing, sieving with a 150-mesh sieve to obtain decoction powder, uniformly stirring the mixed powder and the decoction powder obtained in the step S1, and tabletting to obtain the dendrobium huoshanense throat-soothing buccal tablets.
Example 3
A dendrobium huoshanense buccal tablet for relieving sore throat is prepared from the following raw materials in parts by weight: 30 parts of dendrobium huoshanense, 20 parts of radix ophiopogonis, 10 parts of platycodon grandiflorum, 8 parts of exocarpium citri grandis, 8 parts of mint, 8 parts of liquorice, 15 parts of honey and 15 parts of maltose;
the dendrobium huoshanense buccal tablet for relieving sore throat is prepared by the following steps:
step S1: adding the dendrobium huoshanense into a pulping machine to prepare dendrobium huoshanense juice;
step S2: adding radix Ophiopogonis, radix Platycodi, exocarpium Citri Grandis, herba Menthae and folium Gaultheriae Yunnanensis into superfine pulverizer, pulverizing, sieving with 300 mesh sieve, and mixing to obtain mixed powder;
step S3: adding honey, maltose and the dendrobium huoshanense juice prepared in the step S1 into a decocting device, stirring for 20min at the rotation speed of 1000r/min and the temperature of 125 ℃, and cooling to room temperature to prepare a decocted material;
step S4: adding the decoction obtained in the step S3 into a superfine pulverizer, pulverizing, sieving with a 200-mesh sieve to obtain decoction powder, uniformly stirring the mixed powder and the decoction powder obtained in the step S1, and tabletting to obtain the dendrobium huoshanense throat-soothing buccal tablets.
Comparative example 1
The comparative example is a common throat-soothing buccal tablet in the market.
Clinical tests were carried out on the sore-throat relieving buccal tablets prepared in examples 1 to 3 and comparative example 1, and the test results are shown in tables 1, 2 and 3 below;
a subject: the patients aged 7-75 years and suffering from chronic pharyngitis and laryngopharynx discomfort without major visceral diseases such as severe center of gravity, liver and kidney are 50 subjects in each example, the subjective symptoms of the subjects include pharyngalgia, dry throat, foreign body sensation, halitosis and the like, and at least one item of pharyngeal mucosa edema, mucosa congestion, pharyngeal posterior wall lymph hyperplasia and secretion attachment is detected, wherein the disease course is shortest 1 year and longest 28 years in 25 male patients and 25 female patients;
the taking method comprises the following steps: 3 times daily, 2 granules each time;
efficacy determination criteria: refer to the "clinical research guidelines for new Chinese drugs" published by the ministry of health; the effect is shown: the symptoms are reduced or disappeared, and the pharyngeal physical signs are reduced by grade 2;
the method has the following advantages: the symptoms are reduced, and the pharyngeal physical signs are reduced by 1-2 grades;
and (4) invalidation: no change in symptoms and signs.
TABLE 1 efficacy of Dendrobium huoshanense buccal tablets for relieving sore-throat
Number of examples Show effect Is effective Invalidation The total effective rate%
Example 1 50 23 25 2 96%
Example 2 50 18 31 1 98%
Example 3 50 20 27 1 98%
Comparative example 1 50 13 33 4 92%
TABLE 2 improvement of symptoms
Figure BDA0002441537920000091
TABLE 3 pharyngeal physical signs improvement
Figure BDA0002441537920000092
Figure BDA0002441537920000101
As shown in tables 1-3 above, the sore-throat relieving buccal tablets prepared in examples 1-3 are better in efficacy, symptom improvement and pharyngeal physical sign improvement than those prepared in comparative example 1, the dendrobium huoshanense buccal tablets prepared in the invention contain radix ophiopogonis, platycodon grandiflorum, exocarpium citri grandis, mint and maltose, all of the substances have the efficacies of treating lung deficiency chronic cough, asthma and cough, and the mint and the sweet leaf have the efficacies of sterilizing and removing rot and refreshing breath, and the dendrobium huoshanense is particularly suitable for people with asthenia and debilitation, and has the efficacies of health care and life prolonging.
Referring to fig. 1-10, the decocting apparatus used in the above embodiment includes a base 1, two support pillars 11 oppositely disposed are fixed on an upper surface of the base 1, sliding grooves are formed on side walls of the support pillars 11, slide bars 12 are arranged inside the support pillars 11, sleeves 13 are sleeved on the slide bars 12, the sleeves 13 are slidably connected with the slide bars 12, top pipes 14 are arranged on lower surfaces of the sleeves 13, the top pipes 14 are sleeved with the slide bars 12, the top pipes 14 are slidably connected with the slide bars 12, upper surfaces of the top pipes 14 are attached to lower surfaces of the sleeves 13, springs 15 are fixed on lower surfaces of the top pipes 14, the springs 15 are sleeved on the slide bars 12, bottom ends of the springs 15 are fixedly connected with inner side walls of the support pillars 11, connecting posts 16 are fixed on side walls of the sleeves 13, the connecting posts 16 are matched with the sliding grooves on side walls of the support pillars 11, a cooling water tank 2 is fixed on an upper surface of the base 1, the upper surface of the cooling water tank 2 is provided with a cooling tank 23, a material receiving box 24 is placed in the cooling tank 23, a stirring tank body 3 is arranged above the base 1, the side wall of the stirring tank body 3 is fixedly connected with a connecting column 16, the top end of the stirring tank body 3 is provided with a feeding hole 31, the bottom end of the stirring tank body 3 is provided with a first discharging hole 32 and a second discharging hole 33, the center of the top end of the stirring tank body 3 is fixed with a first motor 34, an output shaft of the first motor 34 is extended and fixed with a first rotating pipe 341, the first rotating pipe 341 is positioned in the stirring tank body 3, the first rotating pipe 341 is rotatably connected with the stirring tank body 3, a second rotating pipe 342 and a third rotating pipe 343 are sequentially arranged below the first rotating pipe 341, two opposite first stirring blades 344 are respectively fixed on two sides of the first rotating pipe 341, the second rotating pipe 342 and the third rotating pipe 343, a stirring side plate 345 is fixed on the end of the first stirring blade 344, and a second motor 35 is fixed on the bottom end of, an output shaft of the second motor 35 extends to be fixed with a stirring shaft 351, the stirring shaft 351 sequentially penetrates through the bottom wall of the stirring box body 3, a third rotating pipe 343, a second rotating pipe 342 and a first rotating pipe 341, the stirring shaft 351 and the bottom wall of the stirring box body 3, the third rotating pipe 343, the second rotating pipe 342 and the first rotating pipe 341 are rotationally connected, a second stirring blade 352 is fixed on the stirring shaft 351, the second stirring blade 352 is positioned between the first rotating pipe 341 and the second rotating pipe 342 and between the second rotating pipe 342 and the third rotating pipe 343, two connecting rods 353 oppositely arranged are further fixed on the stirring shaft 351, a side bottom shovel plate 354 is fixed on the end of each connecting rod 353, two oppositely arranged bottom shovel plates 355 are fixed at the bottom end of the stirring shaft 351, and a heater 36 is further fixed at the top end of the stirring box body 3.
As shown in fig. 2 and 3, the water inlet 21 and the water outlet 22 are located at two sides of the cooling tank 23, the material receiving partition 25 is fixed inside the material receiving box 24, the material receiving partition 25 and the bottom wall of the material receiving box 24 are matched to form a storage tank 26, and a handle 27 is fixed on the side wall of the material receiving box 24.
As shown in fig. 5, 6 and 7, a first screw 311, a second screw 312 and a third screw 313 are disposed inside the feed port 31, the first screw 311, the second screw 312 and the third screw 313 are alternately disposed, the first screw 311, the second screw 312 and the third screw 313 are matched, the first screw 311 is disposed between the second screw 312 and the third screw 313, the first screw 311 is disposed below the second screw 312 and the third screw 313, a first rotating shaft 3111 is fixed at both ends of the first screw 311, the first rotating shaft 3111 is rotatably connected to a sidewall of the feed port 31, a first transmission gear 3112 is fixed on the first rotating shaft 3111, a second rotating shaft 3121 is fixed at both ends of the second screw 312, the second rotating shaft 3121 is rotatably connected to a sidewall of the feed port 31, a second transmission gear 3122 is fixed on the second rotating shaft 3121, a third transmission gear 3131 is fixed at both ends of the third screw 313, a third transmission gear 3132 is fixed on the third rotating shaft 3131, the first transmission gear 3112, the second transmission gear 3122 and the third transmission gear 3132 are located outside the feeding port 31, the first transmission gear 3112 is respectively engaged with the second transmission gear 3122 and the third transmission gear 3132, a supporting plate 314 is fixed on an outer side wall of the feeding port 31, a third motor 315 is fixed on the supporting plate 314, and an output shaft of the third motor 315 is fixedly connected with the first transmission gear 3112.
As shown in fig. 1 and 8, a side wall shovel plate 346 is fixed to a side wall of the stirring side plate 345 away from the first rotating pipe 341, the side wall shovel plate 346 is attached to a side wall inside the stirring box 3, the connecting rod 353 is located below the third rotating pipe 343, the side bottom shovel plate 354 is attached to a side bottom wall inside the stirring box 3, and the bottom shovel plate 355 is attached to a bottom wall inside the stirring box 3.
The feeding port 31, the first discharging port 32 and the second discharging port 33 are internally provided with valves, the valve inside the first discharging port 32 is positioned below the first screw 311, the first discharging port 32 and the second discharging port 33 are respectively positioned at two sides of the second motor 35, and the first discharging port 32 and the second discharging port 33 are positioned above the material receiving box 24.
Working process for preparing the decoction in the examples: the third motor 315 is started to rotate the first rotating shaft 3111, so as to drive the first screw 311 and the first transmission gear 3112, the first transmission gear 3112 drives the second transmission gear 3122 and the third transmission gear 3132 to rotate, the second transmission gear 3122 drives the second screw 312 to rotate, the third transmission gear 3132 drives the third screw 313 to rotate, the honey, the maltose and the dendrobium huoshanense juice prepared in step S1 are added into the stirring box 3 through the feeding port 31, large maltose blocks are crushed under the action of the first screw 311, the second screw 312 and the third screw 313, so as to improve the boiling efficiency of the maltose, the first motor 34, the second motor 35 and the heater 36 are started, the first motor 34 drives the first rotating pipe 341 to rotate, so as to drive the first stirring blade 344 to rotate clockwise at a rotation speed of 800-, the side wall shoveling plate 346 effectively prevents honey and maltose from being adhered to the side wall of the stirring box body 3, the second motor 35 drives the stirring shaft 351 to rotate, the stirring shaft 351 drives the second stirring blade 352 to rotate anticlockwise at the rotating speed of 800 plus 1000r/min, the heater 36 raises the internal temperature of the stirring box body 3 to 125 ℃, the first stirring blade 344 and the second stirring blade 352 stir in opposite directions, vortex flow is effectively prevented from being generated in the boiling process, the axial circulating speed is often lower than the radial circulating speed due to the vortex flow, the stirring effect is influenced, the violently swirling liquid can cause the waves which are reciprocated, the impact force can be generated on the equipment under the action of the vortex, the service life of the equipment is further reduced, the stirring shaft 351 drives the connecting rod 353 and the bottom shoveling plate 355, the connecting rod 353 and then drives the side bottom shoveling plate 354 to rotate, the side bottom shoveling plate 354 and the bottom shoveling plate 355 can stir the raw materials deposited on the bottom side wall and the bottom wall, make stirring efficiency promote, accomplish the system back of stewing, let in the coolant tank 2 with the running water by water inlet 21 and have the delivery port 22 to the running water and flow out, open the valve in first discharge gate 32 and the second discharge gate 33, the system thing of stewing is flowed out by first discharge gate 32 and second discharge gate 33, is collected by receiving box 24, accomplishes the cooling to system thing, and receiving box 24's inside sets up stock chest 26 and makes the volume of mixing thing can not too big, makes things convenient for the use of follow-up technology.
The foregoing is merely exemplary and illustrative of the principles of the present invention and various modifications, additions and substitutions of the specific embodiments described herein may be made by those skilled in the art without departing from the principles of the present invention or exceeding the scope of the claims set forth herein.

Claims (6)

1. A preparation process of dendrobium huoshanense throat-soothing buccal tablets is characterized by comprising the following steps: the dendrobium huoshanense throat-soothing buccal tablet is prepared from the following raw materials in parts by weight: 20-30 parts of dendrobium huoshanense, 15-20 parts of radix ophiopogonis, 8-10 parts of platycodon grandiflorum, 5-8 parts of exocarpium citri grandis, 5-8 parts of mint, 5-8 parts of sweet leaves, 10-15 parts of honey and 10-15 parts of maltose;
the preparation process of the dendrobium huoshanense buccal tablet for relieving sore throat comprises the following steps:
step S1: adding the dendrobium huoshanense into a pulping machine to prepare dendrobium huoshanense juice;
step S2: adding radix Ophiopogonis, radix Platycodi, exocarpium Citri Grandis, herba Menthae and folium Gaultheriae Yunnanensis into superfine pulverizer, pulverizing, sieving with 250-mesh and 300-mesh sieve, and mixing to obtain mixed powder;
step S3: the third motor (315) is started to enable the first rotating shaft (3111) to rotate so as to drive the first screw (311) and the first transmission gear (3112), the first transmission gear (3112) drives the second transmission gear (3122) and the third transmission gear (3132) to rotate, the second transmission gear (3122) drives the second screw (312) to rotate, the third transmission gear (3132) drives the third screw (313) to rotate, honey and maltose are added into the stirring box body (3) from the feeding hole (31), the first motor (34), the second motor (35) and the heater (36) are started, the heater (36) raises the internal temperature of the stirring box body (3) to 120 and 125 ℃, the first motor (34) drives the first rotating pipe (341) to rotate so as to drive the first stirring blade (344) to rotate clockwise at the rotation speed of 1000r/min of 800 and the first stirring blade (344) drives the stirring side plate (345) and the side wall shoveling plate (346) to rotate, the second motor (35) drives the stirring shaft (351) to rotate, the stirring shaft (351) drives the second stirring blade (352) to rotate anticlockwise at the rotating speed of 800-;
step S4: adding the decocted material obtained in the step S3 into an ultrafine grinder, grinding, sieving with a 100-mesh and 200-mesh sieve to obtain decocted material powder, uniformly stirring the mixed powder and the decocted material powder obtained in the step S1, and tabletting to obtain the dendrobium huoshanense throat-soothing buccal tablet.
2. The preparation process of the dendrobium huoshanense buccal tablet according to claim 1, which is characterized in that: the step S3 discloses a stewing device, which comprises a base (1), wherein two support columns (11) which are oppositely arranged are fixed on the upper surface of the base (1), sliding grooves are formed in the side walls of the support columns (11), slide rods (12) are arranged inside the support columns (11), sleeves (13) are sleeved on the slide rods (12), the sleeves (13) are in sliding connection with the slide rods (12), push pipes (14) are arranged on the lower surfaces of the sleeves (13), the push pipes (14) are sleeved with the slide rods (12), the push pipes (14) are in sliding connection with the slide rods (12), the upper surfaces of the push pipes (14) are attached to the lower surfaces of the sleeves (13), springs (15) are fixed on the lower surfaces of the push pipes (14), the springs (15) are sleeved on the slide rods (12), the bottom ends of the springs (15) are fixedly connected with the inner side walls of the support columns (11), connecting columns (16) are fixed on the side walls of the sleeves (13), and the connecting columns (16) are, the upper surface of the base (1) is also fixed with a cooling water tank (2), the upper surface of the cooling water tank (2) is provided with a water inlet (21) and a water outlet (22), the upper surface of the cooling water tank (2) is provided with a cooling tank (23), a material receiving box (24) is placed in the cooling tank (23), a stirring box body (3) is arranged above the base (1), the side wall of the stirring box body (3) is fixedly connected with a connecting column (16), the top end of the stirring box body (3) is provided with a feed inlet (31), the bottom end of the stirring box body (3) is provided with a first discharge outlet (32) and a second discharge outlet (33), a first motor (34) is fixed at the center of the top end of the stirring box body (3), an output shaft of the first motor (34) is fixedly provided with a first rotating pipe (341), the first rotating pipe (341) is positioned inside the stirring box body (3), and the first rotating pipe (341) is rotatably connected, the lower part of first rotating pipe (341) is equipped with second rotating pipe (342) and third rotating pipe (343) in proper order, first rotating pipe (341), second rotating pipe (342), the both sides of third rotating pipe (343) are fixed with two first stirring vane (344) that set up oppositely respectively, be fixed with stirring curb plate (345) on the end of first stirring vane (344), the bottom mounting of agitator tank (3) has second motor (35), be fixed with (mixing) shaft (351) on the output shaft extension of second motor (35), agitator shaft (351) pass agitator tank (3) diapire in proper order, (mixing) shaft (343) third rotating pipe (343), second rotating pipe (342), first rotating pipe (341), agitator shaft (351) and agitator tank (3) diapire, third rotating pipe (343), second rotating pipe (342), first rotating pipe (341) rotate and connect, be fixed with second stirring vane (352) on (mixing) shaft (351), second stirring vane (352) are located between first rotating pipe (341) and second rotating pipe (342), (341), second rotating pipe (351) is fixed with second rotating pipe (351) 342) And between third rotating pipe (343), still be fixed with two connecting rod (353) that set up oppositely on (mixing) shaft (351), the end of connecting rod (353) is fixed with side end shovel board (354), the bottom mounting of (mixing) shaft (351) has two end shovel boards (355) that set up oppositely, and stirring box (3) top still is fixed with heater (36).
3. The preparation process of the dendrobium huoshanense buccal tablet according to claim 2, which is characterized in that: the water inlet (21) and the water outlet (22) are located on two sides of the cooling groove (23), the material receiving partition plate (25) is fixed inside the material receiving box (24), the material receiving partition plate (25) and the bottom wall of the material receiving box (24) are matched to form a storage groove (26), and a handle (27) is fixed on the side wall of the material receiving box (24).
4. The preparation process of the dendrobium huoshanense buccal tablet according to claim 2, which is characterized in that: the feeding port (31) is internally provided with a first screw (311), a second screw (312) and a third screw (313), the first screw (311), the second screw (312) and the third screw (313) are arranged in a staggered manner, the first screw (311), the second screw (312) and the third screw (313) are matched, the first screw (311) is positioned between the second screw (312) and the third screw (313), the first screw (311) is positioned below the second screw (312) and the third screw (313), two ends of the first screw (311) are fixedly provided with a first rotating shaft (3111), the first rotating shaft (3111) is rotatably connected with the side wall of the feeding port (31), a first transmission gear (3112) is fixed on the first rotating shaft (3111), two ends of the second screw (312) are fixedly provided with a second rotating shaft (3121), the second rotating shaft (3121) is rotatably connected with the side wall of the feeding port (31), a second transmission gear (3122) is fixed on the second rotating shaft (3121), a third rotating shaft (3131) is fixed at two ends of the third screw (313), a third transmission gear (3132) is fixed on the third rotating shaft (3131), the first transmission gear (3112), the second transmission gear (3122) and the third transmission gear (3132) are positioned outside the feed port (31), the first transmission gear (3112) is respectively meshed with the second transmission gear (3122) and the third transmission gear (3132), a support plate (314) is fixed on the outer side wall of the feed port (31), a third motor (315) is fixed on the support plate (314), and an output shaft of the third motor (315) extends to be fixedly connected with the first transmission gear (3112).
5. The preparation process of the dendrobium huoshanense buccal tablet according to claim 2, which is characterized in that: the lateral wall of stirring curb plate (345) keeping away from first rotating pipe (341) be fixed with lateral wall shovel board (346), lateral wall shovel board (346) and the laminating of the inside lateral wall of agitator tank body (3), connecting rod (353) are located the below of third rotating pipe (343), side end shovel board (354) and agitator tank body (3) inside side diapire laminating, end shovel board (355) and the laminating of the inside diapire of agitator tank body (3).
6. The preparation process of the dendrobium huoshanense buccal tablet according to claim 2, which is characterized in that: the feeding port (31), the first discharging port (32) and the second discharging port (33) are internally provided with valves, the valve inside the first discharging port (32) is located below the first screw (311), the first discharging port (32) and the second discharging port (33) are respectively located on two sides of the second motor (35), and the first discharging port (32) and the second discharging port (33) are located above the material receiving box (24).
CN202010266674.1A 2020-04-07 2020-04-07 Preparation process of dendrobium huoshanense throat-soothing buccal tablets Withdrawn CN111388601A (en)

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Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111841784A (en) * 2020-07-20 2020-10-30 华益药业科技(安徽)有限公司 Paroxetine processing raw materials reducing mechanism
CN112303900A (en) * 2020-09-24 2021-02-02 江苏通亚电热科技有限公司 Intelligent high-efficient heater
CN113172925A (en) * 2021-05-17 2021-07-27 霍山县天下泽雨生物科技发展有限公司 Preparation method of compound dendrobium huoshanense buccal tablets

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111841784A (en) * 2020-07-20 2020-10-30 华益药业科技(安徽)有限公司 Paroxetine processing raw materials reducing mechanism
CN111841784B (en) * 2020-07-20 2022-05-24 华益药业科技(安徽)有限公司 Paroxetine processing raw materials reducing mechanism
CN112303900A (en) * 2020-09-24 2021-02-02 江苏通亚电热科技有限公司 Intelligent high-efficient heater
CN113172925A (en) * 2021-05-17 2021-07-27 霍山县天下泽雨生物科技发展有限公司 Preparation method of compound dendrobium huoshanense buccal tablets

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