CN111387227A - Preparation method and formula process of antibacterial tablets - Google Patents

Preparation method and formula process of antibacterial tablets Download PDF

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CN111387227A
CN111387227A CN202010466313.1A CN202010466313A CN111387227A CN 111387227 A CN111387227 A CN 111387227A CN 202010466313 A CN202010466313 A CN 202010466313A CN 111387227 A CN111387227 A CN 111387227A
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oil
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张文琳
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    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
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    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01NPRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
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    • A01N65/08Magnoliopsida [dicotyledons]
    • A01N65/28Myrtaceae [Myrtle family], e.g. teatree or clove
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
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    • A01N65/00Biocides, pest repellants or attractants, or plant growth regulators containing material from algae, lichens, bryophyta, multi-cellular fungi or plants, or extracts thereof
    • A01N65/40Liliopsida [monocotyledons]
    • A01N65/44Poaceae or Gramineae [Grass family], e.g. bamboo, lemon grass or citronella grass
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    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
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    • A01N65/00Biocides, pest repellants or attractants, or plant growth regulators containing material from algae, lichens, bryophyta, multi-cellular fungi or plants, or extracts thereof
    • A01N65/40Liliopsida [monocotyledons]
    • A01N65/48Zingiberaceae [Ginger family], e.g. ginger or galangal
    • CCHEMISTRY; METALLURGY
    • C11ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11DDETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D1/00Detergent compositions based essentially on surface-active compounds; Use of these compounds as a detergent
    • C11D1/66Non-ionic compounds
    • C11D1/83Mixtures of non-ionic with anionic compounds
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    • C11ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11DDETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D3/00Other compounding ingredients of detergent compositions covered in group C11D1/00
    • C11D3/02Inorganic compounds ; Elemental compounds
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    • C11ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11DDETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D3/00Other compounding ingredients of detergent compositions covered in group C11D1/00
    • C11D3/16Organic compounds
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    • C11D3/2082Polycarboxylic acids-salts thereof
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    • C11ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11DDETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D1/00Detergent compositions based essentially on surface-active compounds; Use of these compounds as a detergent
    • C11D1/02Anionic compounds
    • C11D1/12Sulfonic acids or sulfuric acid esters; Salts thereof
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    • C11DDETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D1/00Detergent compositions based essentially on surface-active compounds; Use of these compounds as a detergent
    • C11D1/02Anionic compounds
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    • C11D1/29Sulfates of polyoxyalkylene ethers
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    • C11ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11DDETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D1/00Detergent compositions based essentially on surface-active compounds; Use of these compounds as a detergent
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Abstract

The invention discloses a preparation method and a formula process of a bacteriostatic tablet, which comprises the following components: sodium bicarbonate, fumaric acid, polyethylene glycol, sodium dodecyl sulfate, fatty alcohol, sodium polyvinyl ether sulfate, and lauroyl sodium glutamate; citronella extract, clove extract, licorice extract, cardamom extract, burley leaf extract, pine needle extract, cinnamon extract; australian tea tree oil, lavender oil, Shilixiang oil, Eucalyptus globulus oil, rosemary oil and wormwood oil. The product is completely dissolved in water, does not leave particles, can clean heavy pollutants such as grease and ink, is good in biocompatibility, safe and non-toxic, easy in raw material obtaining, low in price, convenient to operate, simple in method, mild in reaction and remarkable in effect, can keep bacteriostatic and antibacterial effects for a long time, and is very small in weight, 0.6 g in weight and convenient to carry in the using process.

Description

Preparation method and formula process of antibacterial tablets
Technical Field
The invention relates to the field of antibacterial tablet processing, in particular to a preparation method, a formula process and a preparation method of an antibacterial tablet.
Background
There are many types of microorganisms, mainly: bacteria, fungi, viruses, and the like; microorganisms easily adsorb and grow on the surface of materials, thereby causing decomposition, deterioration and putrefaction of various industrial materials, cosmetics, pharmaceuticals and the like, and shortening the life of products; therefore, the control and elimination of the growth and reproduction of harmful microorganisms is an important topic closely related to human life and health; the bacteriostatic tablet refers to a substance which is highly sensitive to microorganisms, can prevent the development of microorganisms such as bacteria and fungi, or can inhibit the growth of microorganisms.
Based on the above, the invention finds that the bacteriostatic tablets in the market are not easy to be completely diluted after being dissolved in water, can retain partial particles, have unobvious sterilizing and cleaning effects, and can not remove heavy pollutants such as grease, ink and the like. Therefore, the inventor provides a method for manufacturing a bacteriostatic tablet, a formula process and a manufacturing method thereof, with the experience of design development and actual manufacturing of the related industry being abundant for years, and the existing structure and deficiency being researched and improved, so as to achieve the purpose of higher practical value.
Disclosure of Invention
The invention aims to provide a manufacturing method, a formula process and a manufacturing method of a bacteriostatic tablet, and aims to solve the problems that after the bacteriostatic tablets in the market proposed in the background technology are dissolved in water, the bacteriostatic tablets are not easy to be completely diluted, partial particles are remained, the sterilizing and cleaning effects are not obvious, and severe pollutants such as grease, ink and the like cannot be removed.
In order to achieve the purpose, the invention provides the following technical scheme: a preparation method and a formula process of a bacteriostatic tablet comprise the following components: sodium bicarbonate, fumaric acid, polyethylene glycol, sodium dodecyl sulfate, fatty alcohol, sodium polyvinyl ether sulfate, and lauroyl sodium glutamate; citronella extract, clove extract, licorice extract, cardamom extract, burley leaf extract, pine needle extract, cinnamon extract; australian tea tree oil, lavender oil, Shilixiang oil, Eucalyptus globulus oil, rosemary oil and wormwood oil.
Further, the sodium bicarbonate, the fumaric acid, the polyethylene glycol, the sodium dodecyl sulfate, the fatty alcohol, the sodium polyvinyl ether sulfate and the sodium lauroyl glutamate; citronella extract, clove extract, licorice extract, cardamom extract, burley leaf extract, pine needle extract, cinnamon extract; the total weight of the single seed tablets prepared by mixing Australian tea tree oil, lavender oil, Shilixi oil, Eucalyptus oil, rosemary oil and wormwood oil is 0.60 g.
Further, the sodium bicarbonate, the fumaric acid, the polyethylene glycol, the sodium dodecyl sulfate, the fatty alcohol, the sodium polyvinyl ether sulfate and the sodium lauroyl glutamate are used as raw material medicines and account for 63 percent of the total content, the sodium bicarbonate accounts for 10 percent of the total content, the fumaric acid accounts for 5 percent of the total content, the polyethylene glycol accounts for 10 percent of the total content, the sodium dodecyl sulfate accounts for 10 percent of the total content, the fatty alcohol accounts for 8 percent of the total content, the sodium polyvinyl ether sulfate accounts for 10 percent of the total content, the sodium lauroyl glutamate accounts for 10 percent of the total content, and the total content is 100 percent.
Further, the citronella extract, the clove extract, the licorice extract, the cardamom extract, the burley leaf extract, the pine needle extract and the cinnamon extract are used as extract auxiliary materials and account for 19 percent of the total content, the citronella extract accounts for 3 percent of the total content, the clove extract accounts for 2 percent of the total content, the licorice extract accounts for 3 percent of the total content, the cardamom extract accounts for 2 percent of the total content, the burley leaf extract accounts for 3 percent of the total content, the pine needle extract accounts for 3 percent of the total content, the cinnamon extract accounts for 3 percent of the total content, and the total content is 100 percent.
Further, the Australian tea tree oil, the lavender oil, the shilixi oil, the eucalyptus oil, the rosemary oil and the wormwood oil are lubricating auxiliary materials and account for 18 percent of the total content; australian tea tree oil accounts for 3% of the total content, lavender oil accounts for 3% of the total content, Chinese tulip oil accounts for 5% of the total content, eucalyptus oil accounts for 3% of the total content, rosemary oil accounts for 2% of the total content, wormwood oil accounts for 2% of the total content, and the total content is 100%.
Further, a method for manufacturing the bacteriostatic tablet and a method for manufacturing the formula process comprise the following steps:
1) mixing 10 parts of sodium bicarbonate, 5 parts of fumaric acid, 10 parts of polyethylene glycol, 10 parts of sodium dodecyl sulfate, 8 parts of fatty alcohol, 10 parts of polyvinyl ether sodium sulfate and 10 parts of sodium lauroyl glutamate, and uniformly stirring;
2) mixing 3 parts of citronella extract, 2 parts of clove extract, 3 parts of liquorice extract, 2 parts of cardamom extract, 3 parts of lateral bur leaf extract, 3 parts of pine needle extract and 3 parts of cinnamon extract, and stirring uniformly;
3) adding the extract mixture obtained in the step 2) into the mixture obtained in the step 1), stirring, and uniformly stirring to prepare plastic masses, wherein the plastic masses are required to be kneaded into masses without sticking; it will break and crack without scattering;
4) manually or mechanically extruding the lumps obtained in the step 3) through a screen to obtain wet granules, wherein the granules are required to have heaviness, less fine powder, integrity and no long strip;
5) after the wet particles are prepared, immediately drying the wet particles to avoid agglomeration or compression deformation, flatly paving the wet particles in a drying room or an oven, wherein the thickness of the wet particles is within 2cm, the drying temperature is gradually increased and is increased to 50 ℃, the wet particles are frequently turned over during drying, the drying degree of the particles is controlled by measuring the water content, and the water content is controlled to be 3%;
6) mixing 3 parts of Australian tea tree oil, 3 parts of lavender oil, 5 parts of Shilixian oil, 3 parts of Eucalyptus oil, 2 parts of rosemary oil and 2 parts of wormwood oil, and uniformly stirring to prepare a lubricant;
7) screening and finishing the dry granules in the step 5) to separate the granules which are adhered and agglomerated;
8) and mixing the essential oil mixture in the step 6), namely the lubricant, with the granules in the step 7, tabletting by using a single-punch tablet press or a rotary tablet press, and packaging.
Compared with the prior art, the invention has the beneficial effects that:
the product is completely dissolved in water, does not leave particles, can clean heavy pollutants such as grease and ink, is good in biocompatibility, safe and non-toxic, easy in raw material obtaining, low in price, convenient to operate, simple in method, mild in reaction and remarkable in effect, can keep bacteriostatic and antibacterial effects for a long time, and is very small in weight, 0.6 g in weight and convenient to carry in the using process.
Detailed Description
The technical solutions in the embodiments of the present invention are clearly and completely described below, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
The invention provides a technical scheme that: a preparation method and a formula process of a bacteriostatic tablet comprise the following components: sodium bicarbonate, fumaric acid, polyethylene glycol, sodium dodecyl sulfate, fatty alcohol, sodium polyvinyl ether sulfate, and lauroyl sodium glutamate; citronella extract, clove extract, licorice extract, cardamom extract, burley leaf extract, pine needle extract, cinnamon extract; australian tea tree oil, lavender oil, Shilixiang oil, Eucalyptus globulus oil, rosemary oil and wormwood oil.
Sodium bicarbonate, fumaric acid, polyethylene glycol, sodium dodecyl sulfate, fatty alcohol, sodium polyvinyl ether sulfate, and lauroyl sodium glutamate; citronella extract, clove extract, licorice extract, cardamom extract, burley leaf extract, pine needle extract, cinnamon extract; the total weight of the single seed tablets prepared by mixing Australian tea tree oil, lavender oil, Shilixi oil, Eucalyptus oil, rosemary oil and wormwood oil is 0.60 g.
Sodium bicarbonate, fumaric acid, polyethylene glycol, sodium dodecyl sulfate, fatty alcohol, sodium polyvinyl ether sulfate and sodium lauroyl glutamate which are used as raw material medicines account for 63 percent of the total content, the sodium bicarbonate accounts for 10 percent of the total content, the fumaric acid accounts for 5 percent of the total content, the polyethylene glycol accounts for 10 percent of the total content, the sodium dodecyl sulfate accounts for 10 percent of the total content, the fatty alcohol accounts for 8 percent of the total content, the sodium polyvinyl ether sulfate accounts for 10 percent of the total content, and the sodium lauroyl glutamate accounts for 10 percent of the total content; the citronella extract, the clove extract, the licorice extract, the cardamom extract, the lateral bur leaf extract, the pine needle extract and the cinnamon extract are taken as extract auxiliary materials and account for 19 percent of the total content, the citronella extract accounts for 3 percent of the total content, the clove extract accounts for 2 percent of the total content, the licorice extract accounts for 3 percent of the total content, the cardamom extract accounts for 2 percent of the total content, the lateral bur leaf extract accounts for 3 percent of the total content, the pine needle extract accounts for 3 percent of the total content, and the cinnamon extract accounts for 3 percent of the total content; australian tea tree oil, lavender oil, Shilixiang oil, Eucalyptus oil, riddle balm oil and wormwood oil are used as lubricating auxiliary materials and account for 18 percent of the total content; australian tea tree oil accounts for 3% of the total content, lavender oil accounts for 3% of the total content, Chinese tulip oil accounts for 5% of the total content, eucalyptus oil accounts for 3% of the total content, rosemary oil accounts for 2% of the total content, wormwood oil accounts for 2% of the total content, and the total content is 100%.
A method for preparing bacteriostatic tablets and a method for preparing a formula process comprise the following steps:
1) mixing 10 parts of sodium bicarbonate, 5 parts of fumaric acid, 10 parts of polyethylene glycol, 10 parts of sodium dodecyl sulfate, 8 parts of fatty alcohol, 10 parts of polyvinyl ether sodium sulfate and 10 parts of sodium lauroyl glutamate, and uniformly stirring;
2) mixing 3 parts of citronella extract, 2 parts of clove extract, 3 parts of liquorice extract, 2 parts of cardamom extract, 3 parts of lateral bur leaf extract, 3 parts of pine needle extract and 3 parts of cinnamon extract, and stirring uniformly;
3) adding the extract mixture obtained in the step 2) into the mixture obtained in the step 1), stirring, and uniformly stirring to prepare plastic masses, wherein the plastic masses are required to be kneaded into masses without sticking; it will break and crack without scattering;
4) manually or mechanically extruding the lumps obtained in the step 3) through a screen to obtain wet granules, wherein the granules are required to have heaviness, less fine powder, integrity and no long strip;
5) after the wet particles are prepared, immediately drying the wet particles to avoid agglomeration or compression deformation, flatly paving the wet particles in a drying room or an oven, wherein the thickness of the wet particles is within 2cm, the drying temperature is gradually increased and is increased to 50 ℃, the wet particles are frequently turned over during drying, the drying degree of the particles is controlled by measuring the water content, and the water content is controlled to be 3%;
6) mixing 3 parts of Australian tea tree oil, 3 parts of lavender oil, 5 parts of Shilixian oil, 3 parts of Eucalyptus oil, 2 parts of rosemary oil and 2 parts of wormwood oil, and uniformly stirring to prepare a lubricant;
7) screening and finishing the dry granules in the step 5) to separate the granules which are adhered and agglomerated;
8) and mixing the essential oil mixture in the step 6), namely the lubricant, with the granules in the step 7, tabletting by using a single-punch tablet press or a rotary tablet press, and packaging.
When the bacteriostatic tablet is used, the bacteriostatic tablet is completely dissolved in water, does not leave particles, can clean heavy pollutants such as grease and ink, is good in biocompatibility, safe and non-toxic, easy to obtain raw materials, low in price, convenient to operate, simple in method, mild in reaction and remarkable in effect, can keep bacteriostatic and antibacterial effects for a long time, is 0.6 g in weight, is extremely small in weight, and is convenient to carry in the using process.
Although the present invention has been described in detail with reference to the foregoing embodiments, it will be apparent to those skilled in the art that various changes in the embodiments and/or modifications of the invention can be made, and equivalents and modifications of some features of the invention can be made without departing from the spirit and scope of the invention.

Claims (6)

1. A preparation method and a formula process of a bacteriostatic tablet, wherein the bacteriostatic tablet comprises the following components: sodium bicarbonate, fumaric acid, polyethylene glycol, sodium dodecyl sulfate, fatty alcohol, sodium polyvinyl ether sulfate, and lauroyl sodium glutamate; citronella extract, clove extract, licorice extract, cardamom extract, burley leaf extract, pine needle extract, cinnamon extract; australian tea tree oil, lavender oil, Shilixiang oil, Eucalyptus globulus oil, rosemary oil and wormwood oil.
2. The formulation process of the bacteriostatic tablet according to claim 1, wherein the formulation process comprises the following steps: the sodium bicarbonate, the fumaric acid, the polyethylene glycol, the sodium dodecyl sulfate, the fatty alcohol, the sodium polyvinyl ether sulfate and the lauroyl sodium glutamate; citronella extract, clove extract, licorice extract, cardamom extract, burley leaf extract, pine needle extract, cinnamon extract; the total weight of the single seed tablets prepared by mixing Australian tea tree oil, lavender oil, Shilixi oil, Eucalyptus oil, rosemary oil and wormwood oil is 0.60 g.
3. The formulation process of the bacteriostatic tablet according to claim 1, wherein the formulation process comprises the following steps: the sodium bicarbonate, the fumaric acid, the polyethylene glycol, the sodium dodecyl sulfate, the fatty alcohol, the sodium polyvinyl ether sulfate and the lauroyl sodium glutamate are used as raw material medicines and account for 63 percent of the total content, the sodium bicarbonate accounts for 10 percent of the total content, the fumaric acid accounts for 5 percent of the total content, the polyethylene glycol accounts for 10 percent of the total content, the lauryl sodium sulfate accounts for 10 percent of the total content, the fatty alcohol accounts for 8 percent of the total content, the sodium polyvinyl ether sulfate accounts for 10 percent of the total content, the lauroyl sodium glutamate accounts for 10 percent of the total content, and the total content is 100 percent.
4. The formulation process of the bacteriostatic tablet according to claim 1, wherein the formulation process comprises the following steps: the citronella extract, the clove extract, the licorice extract, the cardamom extract, the lateral bur leaf extract, the pine needle extract and the cinnamon extract are used as extract auxiliary materials and account for 19 percent of the total content, the citronella extract accounts for 3 percent of the total content, the clove extract accounts for 2 percent of the total content, the licorice extract accounts for 3 percent of the total content, the cardamom extract accounts for 2 percent of the total content, the lateral bur leaf extract accounts for 3 percent of the total content, the pine needle extract accounts for 3 percent of the total content, the cinnamon extract accounts for 3 percent of the total content, and the total content is 100 percent.
5. The formulation process of the bacteriostatic tablet according to claim 1, wherein the formulation process comprises the following steps: the Australian tea tree oil, the lavender oil, the Shilixian oil, the eucalyptus oil, the rosemary oil and the wormwood oil are lubricating auxiliary materials and account for 18 percent of the total content; australian tea tree oil accounts for 3% of the total content, lavender oil accounts for 3% of the total content, Chinese tulip oil accounts for 5% of the total content, eucalyptus oil accounts for 3% of the total content, rosemary oil accounts for 2% of the total content, wormwood oil accounts for 2% of the total content, and the total content is 100%.
6. The method for manufacturing the bacteriostatic tablet according to claim 1, wherein the bacteriostatic tablet comprises the following steps: the method comprises the following steps:
1) mixing 10 parts of sodium bicarbonate, 5 parts of fumaric acid, 10 parts of polyethylene glycol, 10 parts of sodium dodecyl sulfate, 8 parts of fatty alcohol, 10 parts of polyvinyl ether sodium sulfate and 10 parts of sodium lauroyl glutamate, and uniformly stirring;
2) mixing 3 parts of citronella extract, 2 parts of clove extract, 3 parts of liquorice extract, 2 parts of cardamom extract, 3 parts of lateral bur leaf extract, 3 parts of pine needle extract and 3 parts of cinnamon extract, and stirring uniformly;
3) adding the extract mixture obtained in the step 2) into the mixture obtained in the step 1), stirring, and uniformly stirring to prepare plastic masses, wherein the plastic masses are required to be kneaded into masses without sticking; it will break and crack without scattering;
4) manually or mechanically extruding the lumps obtained in the step 3) through a screen to obtain wet granules, wherein the granules are required to have heaviness, less fine powder, integrity and no long strip;
5) after the wet particles are prepared, immediately drying the wet particles to avoid agglomeration or compression deformation, flatly paving the wet particles in a drying room or an oven, wherein the thickness of the wet particles is within 2cm, the drying temperature is gradually increased and is increased to 50 ℃, the wet particles are frequently turned over during drying, the drying degree of the particles is controlled by measuring the water content, and the water content is controlled to be 3%;
6) mixing 3 parts of Australian tea tree oil, 3 parts of lavender oil, 5 parts of Shilixian oil, 3 parts of Eucalyptus oil, 2 parts of rosemary oil and 2 parts of wormwood oil, and uniformly stirring to prepare a lubricant;
7) screening and finishing the dry granules in the step 5) to separate the granules which are adhered and agglomerated;
8) and mixing the essential oil mixture in the step 6), namely the lubricant, with the granules in the step 7, tabletting by using a single-punch tablet press or a rotary tablet press, and packaging.
CN202010466313.1A 2020-05-28 2020-05-28 Preparation method and formula process of antibacterial tablets Pending CN111387227A (en)

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