CN111374149A - Hydrogen peroxide-based disinfection sterilizing agent and preparation method thereof - Google Patents

Hydrogen peroxide-based disinfection sterilizing agent and preparation method thereof Download PDF

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CN111374149A
CN111374149A CN202010364003.9A CN202010364003A CN111374149A CN 111374149 A CN111374149 A CN 111374149A CN 202010364003 A CN202010364003 A CN 202010364003A CN 111374149 A CN111374149 A CN 111374149A
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lactam
hydrogen peroxide
group
sterilizer
containing polymer
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严敬华
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Zhejiang Shiweikang Biomedical Materials Co ltd
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Zhejiang Shiweikang Biomedical Materials Co ltd
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    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
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Abstract

The application belongs to the technical field of disinfectants, and particularly relates to a hydrogen peroxide-based disinfection sterilizing agent and a preparation method thereof. The raw materials of the sterilizing agent comprise: 10-20g of nano silver compound; 1-3mL of hydrogen peroxide; 3-8g of plant extract; the water was replenished to 1000 mL. The sterilizing agent has excellent sterilizing performance and good stability, can be used on the surface of any object, including but not limited to human skin, tiles, walls, floors, alloys, bathrooms, glass, tabletops, cooking benches, washing pools, toilets, clothes, curtains, sheets, bedding products, sofas, refrigerators, freezers, washing machines, microwave ovens, mops, plastics, rubbers and the like, and can also be used for air sterilization, for example, the indoor environment is infected by pathogens such as bacteria, viruses and the like on suspended particles.

Description

Hydrogen peroxide-based disinfection sterilizing agent and preparation method thereof
Technical Field
The application belongs to the technical field of disinfectants, and particularly relates to a hydrogen peroxide-based disinfection sterilizing agent and a preparation method thereof.
Background
Sterilization and disinfection are indispensable links in production and life of people, especially in the present day when the novel coronavirus is very serious; however, the traditional sterilizing disinfectant, such as chlorine series sterilizing products, has poor sterilizing and disinfecting performance and can leave harmful substances; hydrogen peroxide with a certain concentration can be used as a disinfectant for sterilization and disinfection, but the hydrogen peroxide has poor storage stability; the slow sterilization speed of the hydrogen peroxide, the high concentration required and the like result in less extensive application.
The emergence of nanotechnology makes the bactericidal performance of silver in a nanometer state generate qualitative leap. The nano silver can generate strong sterilization effect under the condition of small dosage, has strong permeability, broad sterilization effect and no drug resistance; and the nano silver can promote the healing of wounds, the growth of cells and the repair of damaged cells, has no toxic reaction and has no stimulation reaction on skin. Therefore, the nano silver antibacterial material can be applied to the fields of functional plastics, functional coatings, textile fibers, air purification, food, daily chemicals, medical treatment and the like, has a very wide market prospect, and gradually becomes a research hotspot in recent years. The nano silver has strong inhibition and killing effects on dozens of pathogenic microorganisms such as escherichia coli, gonococcus, chlamydia trachomatis and the like, and can not generate drug resistance.
However, the existing hydrogen peroxide sterilization disinfectant also has the defects of weak sterilization capability, poor stability and the like.
Disclosure of Invention
In order to solve the technical problems, the first aspect of the invention provides a hydrogen peroxide-based disinfectant, which comprises the following raw materials: 10-20g of nano silver compound; 1-3mL of hydrogen peroxide; 3-8g of plant extract; supplementing water to 1000 mL; wherein the plant extract is at least one selected from berberine, flos Lonicerae extract, green tea extract, and radix Sophorae Flavescentis extract.
As a preferred technical scheme, the raw materials for preparing the nano-silver compound comprise: glucose, lactam-containing polymers and/or sodium alkyl sulfosuccinate, silver salts.
As a preferred technical scheme, the lactam group-containing polymer has a lactam group dipole moment of 30-42.
As a preferable embodiment, the lactam group of the lactam-group containing polymer is a butyrolactam group.
As a preferable technical scheme, the long chain of the lactam-group-containing polymer further comprises methylene groups, the two ends of the lactam group of the lactam-group-containing polymer are in different environments, one end of an oxygen atom is exposed, and one end of an N atom is surrounded by methyl and methylene groups.
As a preferable embodiment, the viscosity (mPa.s/25 ℃/5% aq) of the lactam group-containing polymer is 1.1 to 2.7, and the number average molecular weight is 10000-40000.
As a preferable technical scheme, the mass ratio of the lactam group-containing polymer to the sodium sulfosuccinate alkyl ester is (2-4): 1.
as a preferable embodiment, the alkyl group in the sodium sulfosuccinate is at least one selected from the group consisting of ethyl group, propyl group, isopropyl group, n-butyl group, isobutyl group, sec-butyl group, tert-butyl group, n-pentyl group, isopentyl group, sec-pentyl group, tert-pentyl group, n-hexyl group, isohexyl group, n-octyl group, and isooctyl group.
As a preferable technical scheme, the raw material also comprises a pH regulator.
The second aspect of the invention provides the preparation method, which comprises the following steps: adding hydrogen peroxide and plant extract into the nano-silver compound, stirring uniformly, adding a pH regulator and adding water to supplement to 1000 mL.
Has the advantages that: the sterilizing agent has excellent sterilizing performance and good stability, can be used on the surfaces of any objects, including but not limited to human skin, tiles, walls, floors, alloys, bathrooms, glass, tabletops, cooking benches, washing pools, toilets, clothes, curtains, sheets, bedding products, sofas, refrigerators, freezers, washing machines, microwave ovens, mops, plastics, rubbers and the like, and can also be used for air sterilization, for example, the indoor environment is infected by pathogens such as bacteria, viruses and the like on suspended particles; volatile gaseous pollutants such as radon, formaldehyde, benzene series, ammonia and the like after decoration and fitment; inhalable particles such as dust, smoke, pollen, etc.; the peculiar smell of life, such as metabolism in a new city, musty smell, garbage smell and the like; and (3) invasion of outdoor polluted air, such as industrial waste gas, automobile tail gas, soil bag dust and the like.
Detailed Description
For purposes of the following detailed description, it is to be understood that the invention may assume various alternative variations and step sequences, except where expressly specified to the contrary. Moreover, other than in any operating examples, or where otherwise indicated, all numbers expressing, for example, quantities of ingredients used in the specification and claims are to be understood as being modified in all instances by the term "about". Accordingly, unless indicated to the contrary, the numerical parameters set forth in the following specification and attached claims are approximations that may vary depending upon the desired properties to be obtained by the present invention. At the very least, and not as an attempt to limit the application of the doctrine of equivalents to the scope of the claims, each numerical parameter should at least be construed in light of the number of reported significant digits and by applying ordinary rounding techniques.
Notwithstanding that the numerical ranges and parameters setting forth the broad scope of the invention are approximations, the numerical values set forth in the specific examples are reported as precisely as possible. Any numerical value, however, inherently contains certain errors necessarily resulting from the standard deviation found in their respective testing measurements.
When a range of values is disclosed herein, the range is considered to be continuous and includes both the minimum and maximum values of the range, as well as each value between such minimum and maximum values. Further, when a range refers to an integer, each integer between the minimum and maximum values of the range is included. Further, when multiple range-describing features or characteristics are provided, the ranges may be combined. In other words, unless otherwise indicated, all ranges disclosed herein are to be understood to encompass any and all subranges subsumed therein. For example, a stated range from "1 to 10" should be considered to include any and all subranges between the minimum value of 1 and the maximum value of 10. Exemplary subranges of the range 1 to 10 include, but are not limited to, 1 to 6.1, 3.5 to 7.8, 5.5 to 10, and the like.
In order to solve the problems, the invention provides a hydrogen peroxide-based disinfectant, which comprises the following raw materials: 10-20g of nano silver compound; 1-3mL of hydrogen peroxide; 3-8g of plant extract; supplementing water to 1000 mL; wherein the plant extract is at least one selected from berberine, flos Lonicerae extract, green tea extract, and radix Sophorae Flavescentis extract.
Nano silver composite
As a preferred embodiment, the raw materials for preparing the nano silver composite comprise: glucose, lactam-containing polymers and/or sodium, silver salts of alkyl succinates.
As a preferred embodiment, the method for preparing the nano silver composite comprises the following steps: (1) adding 0.10g of glucose, 0.080g of lactam group-containing polymer and/or sodium sulfosuccinate alkyl ester, 0.8g of sodium glutamate and 0.013g of sodium hydroxide into water in sequence at the rotation speed of 1000-; (2) heating to 50-70 ℃, adding 5mL of silver nitrate solution, continuing heating and stirring, and reacting for 5-7 hours to obtain the nano-silver compound.
Wherein the concentration of the silver nitrate is 0.01 mol/L.
In the application, the sodium glutamate is added to promote the compatibility of the nano-silver compound with other components and improve the stability.
As a preferred embodiment, the mass ratio of the lactam-group containing polymer to the sodium sulfosuccinate alkyl ester is (2-4): 1.
as a preferred embodiment, the lactam-group containing polymer has a lactam-group dipole moment of 30 to 42; preferably, the lactam group of the lactam group-containing polymer is a butyrolactam group; more preferably, the lactam-group containing polymer further comprises a methylene group in the long chain; further preferably, the environments of both ends of the lactam group-containing polymer are different, one end of the oxygen atom is exposed, and the other end of the N atom is surrounded by a methyl group and a methylene group.
As a preferred embodiment, the lactam group-containing polymer has a viscosity (mPa.s/25 ℃/5% aq) of 1.1 to 2.7 and a number average molecular weight of 10000-40000.
In a preferred embodiment, the alkyl group in the sodium sulfosuccinate is at least one selected from the group consisting of ethyl, propyl, isopropyl, n-butyl, isobutyl, sec-butyl, tert-butyl, n-pentyl, isopentyl, sec-pentyl, tert-pentyl, n-hexyl, isohexyl, n-octyl, and isooctyl.
More preferably, the alkyl group in the sodium sulfosuccinate is n-hexyl.
The preparation method of the sodium alkyl sulfosuccinate with n-hexyl alkyl comprises the following steps: 1) adding 4mol of maleic anhydride, 2mol of 1, 3-propylene glycol and a solid acid catalyst (the solid acid catalyst is 3 wt% of the maleic anhydride) into a reactor, uniformly stirring, heating to 100 +/-2.5 ℃, and reacting for 5-6 hours; 2) adding 5mol of n-hexanol into the step 1), uniformly stirring and heating to 200 +/-2.5 ℃, reacting for 4-5 hours to obtain a mixed solution of a compound 2, and filtering to remove the catalyst; 3) reducing the temperature to 110 +/-2.5 ℃, adding sodium hydroxide in the step 2) to adjust the pH value to 7, then adding 4mol of sodium bisulfite (sodium bisulfite water solution with the mass concentration of 35%) and reacting for 40-60min to obtain the sodium hydrogen sulfite. Wherein the solid acid catalyst is purchased from south university synthetic chemistry, ltd.
The nano silver obtained by the method can be combined with sulfydryl in metabolic enzyme of pathogenic bacteria, so that the metabolic enzyme loses activity; and form a reversible complex after reacting with peptidoglycan of the exposed bacterial cell wall, preventing the bacteria from transporting oxygen and energy into the cell interior; can also combine with the DNA of pathogenic bacteria to cause the structural denaturation of the DNA, and finally inhibit the DNA replication; particularly, the polymer containing lactam group and the sodium sulfosuccinate alkyl ester are added in the preparation process, so that the prepared disinfection sterilizing agent has excellent sterilizing performance; the conjecture is that the long chain of the polymer containing lactam group comprises methylene groups, the two ends of the lactam group are in different environments, so that the polymer is easy to adsorb on the surface of the generated nano-silver to play a role in protection, and after the alkyl ester sodium sulfosuccinate is added, the adsorption rate of the polymer containing lactam group and the newly generated nano-particles is promoted to be greater than the rate of Ag mutual aggregation, so that the obtained nano-silver has strong penetrating power while the surface activity is enhanced.
Hydrogen peroxide
Pure hydrogen peroxide is light blue viscous liquid, can be mixed and dissolved with water in any proportion, and is a strong oxidant; the medical hydrogen peroxide can kill intestinal pathogenic bacteria, pyogenic coccus and pathogenic yeast, and is generally used for disinfecting the surfaces of objects. The hydrogen peroxide has the oxidation effect, but the concentration of the medical hydrogen peroxide is equal to or lower than 3 percent, when the medical hydrogen peroxide is wiped on a wound surface, the wound surface can be burnt, and the surface is oxidized into white and bubbles are generated.
The hydrogen peroxide is a commercial product, and can be enumerated by 27.5% of hydrogen peroxide, 35% of hydrogen peroxide and 50% of hydrogen peroxide, and the hydrogen peroxide is 35% of hydrogen peroxide in mass fraction in the application and purchased from fine chemical engineering in the day of Anhui Ling.
Plant extracts
As a preferred embodiment, the plant extracts are berberine and honeysuckle extracts.
The berberine is also called berberine, is mainly distributed in a plurality of plants such as coptis chinensis, phellodendron and the like, and is a main effective component for resisting bacteria of the coptis chinensis. It is yellow needle-like crystal and bitter in taste. CAS number 2086-83-1. The berberine has wide antibacterial spectrum, and has antibacterial effect on multiple gram positive and negative bacteria in vitro, such as hemolytic streptococcus, Staphylococcus aureus, and Vibrio cholerae. Has strong inhibiting effect on meningococcus, shigella dysenteriae, typhoid bacillus, diphtheria bacillus and the like.
The flos Lonicerae is dried flower bud or flower with initial bloom of Lonicera japonica Thunb, Lonicera japonica Thunb DC or Lonicera japonica Thunb of Caprifoliaceae, Lonicera japonica flower contains chlorogenic acid (chlorophromonic acid), Isochlorogenin acid (isochlorogenin acid), ginkgol (ginnol), β -sitosterol (β -sitosterol), stigmasterol (stigmasterol), β -sitosterol-D-glucoside (β -sitosterol-D-gluco-side), stigmasterol-D-glucoside (stigmasterol-D-glucoside), linalool (linalool), L-geranyl-2-D-hydroxypyrol-D-glucoside (cetyl-D-linolenic acid), linalool-2-methyl benzoate (cetyl alcohol), cis-2-methyl benzoate-3-2-methyl benzoate-2-3-ethyl benzoate), cis-2-cyclopentenyl-2-3-methyl benzoate (cetyl alcohol), trans-methyl benzoate-2-methyl benzoate-3-ethyl benzoate (cetyl alcohol), trans-methyl benzoate-2-ethyl benzoate (cetyl benzoate), cis-3-methyl benzoate (cetyl benzoate), trans-linolenic acid-2-linolenic acid (cetyl alcohol, cis-D-linolenic acid-D-linolenic acid, cis-2-linolenic acid, cis-2-linolenic acid, cis-2-linolenic acid, cis-2-linolenic acid, trans-linolenic acid, cis-2-linolenic acid, cis-2-3-linolenic acid, or trans-2-3-2-ethyl benzoate, or trans-3-2-.
The honeysuckle flower extract has an inhibitory effect on various bacteria (typhoid bacillus, paratyphoid bacillus, escherichia coli, proteus, pseudomonas aeruginosa, bordetella pertussis, vibrio cholerae, staphylococcus, streptococcus, diplococcus pneumoniae, meningococcus and the like) in vitro.
Preferably, the weight ratio of the berberine to the honeysuckle extract is 1: (1-2).
The applicant has found that the outermost layer of the cell wall of gram-negative bacteria is a layer of lipopolysaccharide, and the inner layer is a thin layer of peptidoglycan, the lipopolysaccharide is covalently linked by lipids and polysaccharides, and the whole lacks strength and hardness; the cell wall of gram-positive bacteria is mainly composed of peptidoglycan, linear peptidoglycan is connected by small peptides into a mutually cross-linked reticular three-dimensional structure which is thicker and more compact than that of negative bacteria, and nano silver is difficult to anchor on the peptidoglycan and difficult to penetrate through the cell wall, so that the inhibitory action of the nano silver on the gram-positive bacteria is weaker. The application improves the inhibiting effect of the sterilizing agent on staphylococcus aureus by adding the plant extract, and the applicant also finds that when the plant extract is the berberine and the honeysuckle extract, the berberine and the honeysuckle extract are mutually synergistic, so that the prepared sterilizing agent has a synergistic antibacterial effect on the staphylococcus aureus and escherichia coli.
Preferably, the raw materials of the hydrogen peroxide-based disinfectant and sterilization agent further comprise a pH regulator; the pH regulator is not particularly limited, and can adjust the pH of the disinfectant to 4-6 without affecting the purpose of the invention; preferably, the pH adjusting agent is citric acid.
A second aspect of the present invention provides a method of preparing the hydrogen peroxide-based sanitizer, comprising the steps of: adding hydrogen peroxide and plant extract into the nano-silver compound, stirring uniformly, adding a pH regulator and adding water to supplement to 1000 mL.
Because the honeysuckle extract contains chlorogenic acid, the honeysuckle extract is easy to be complexed with sodium glutamate and the like, so that the disinfectant is in a turbid state, and the service performance of the disinfectant is influenced; the application discovers that when the viscosity (mPa.s/25 ℃/5% aq) of the lactam-group-containing polymer is 1.1-2.7 and the number average molecular weight is 10000-40000, the lactam-group-containing polymer can be complexed with chlorogenic acid, glucose and the like, so that the disinfectant is clear, the storage stability of the disinfectant is improved, and the shelf life is prolonged; in particular, the mass ratio of the lactam-containing polymer to the succinic acid alkyl ester sodium sulfonate is (2-4): 1, even if the disinfectant is placed at 50 ℃ for 72 hours, the disinfectant still presents a clear state; however, the mass ratio of the lactam-containing polymer to the sodium sulfosuccinate alkyl ester is (2-4): 1, the double electric layers of the nano-silver in the system are influenced, so that the dispersibility of the system is poor; the present applicant has unexpectedly found that when the alkyl group in the sodium sulfosuccinate is n-hexyl, the repulsive force between nano-silver is increased while preventing brownian-moving particles from approaching, thereby improving dispersion stability.
The disinfectant can be used on the surface of any object, including but not limited to human skin, ceramic tiles, walls, floors, alloys, bathrooms, glass, tabletops, cooktops, sinks, toilets, clothes, curtains, sheets, bedding products, sofas, refrigerators, freezers, washing machines, microwave ovens, mops, plastics, rubber, etc., and can also be used for air disinfection, for example, the indoor environment is infected by pathogens such as bacteria, viruses, etc. on suspended particles; volatile gaseous pollutants such as radon, formaldehyde, benzene series, ammonia and the like after decoration and fitment; inhalable particles such as dust, smoke, pollen, etc.; the peculiar smell of life, such as metabolism in a new city, musty smell, garbage smell and the like; and (3) invasion of outdoor polluted air, such as industrial waste gas, automobile tail gas, soil bag dust and the like.
The present invention will be specifically described below by way of examples. It should be noted that the following examples are only for illustrating the present invention and should not be construed as limiting the scope of the present invention, and that the insubstantial modifications and adaptations of the present invention by those skilled in the art based on the above disclosure are still within the scope of the present invention.
In addition, the starting materials used are all commercially available, unless otherwise specified.
Examples
Example 1
A hydrogen peroxide-based disinfecting sterilant comprising the following raw materials: 15g of nano silver compound; 2mL of hydrogen peroxide; 6g of plant extract; proper amount of citric acid and water are added to 1000 mL.
The preparation method of the nano-silver compound comprises the following steps: (1) sequentially adding 0.10g of glucose, 0.080g of polyvinylpyrrolidone, sodium sulfosuccinate alkyl ester sulfonate, 0.8g of sodium glutamate and 0.013g of sodium hydroxide into 25mL of water at the rotating speed of 1000r/min, and stirring until the mixture is transparent and clear; (2) and (3) heating to 60 ℃, adding 5mL of silver nitrate solution (the concentration of the silver nitrate is 0.01mol/L), continuously heating and stirring, and reacting for 6 hours to obtain the nano-silver compound.
The mass ratio of the polyvinylpyrrolidone to the sodium alkyl succinate sulfonate is 3: 1.
the polyvinylpyrrolidone is purchased from Ganbuke New Material science and technology (Shanghai) Co., Ltd, and the product specification is PVPK 30.
The alkyl in the succinic acid alkyl ester sodium sulfonate is n-hexyl. The preparation method of the sodium alkyl sulfosuccinate with n-hexyl alkyl comprises the following steps: 1) adding 4mol of maleic anhydride, 2mol of 1, 3-propylene glycol and a solid acid catalyst (the solid acid catalyst is 3 wt% of the maleic anhydride) into a reactor, uniformly stirring, heating to 100 +/-2.5 ℃, and reacting for 5 hours; 2) adding 5mol of n-hexanol into the step 1), uniformly stirring, heating to 200 +/-2.5 ℃, reacting for 4 hours to obtain a mixed solution of a compound 2, and filtering to remove the catalyst; 3) reducing the temperature to 110 +/-2.5 ℃, adding sodium hydroxide in the step 2) to adjust the pH value to 7, then adding 4mol of sodium bisulfite (sodium bisulfite water solution with the mass concentration of 35%) and reacting for 50min to obtain the sodium hydrogen sulfite. Wherein the solid acid catalyst is purchased from south university synthetic chemistry, ltd.
The hydrogen peroxide is 35% hydrogen peroxide by mass and is purchased from fine chemical engineering in Rabdosia.
The plant extracts comprise berberine and honeysuckle extracts, and the weight ratio of the berberine to the honeysuckle extracts is 1: 1.3. the honeysuckle extract was purchased from Shanghai grass Biotech limited.
The preparation method of the hydrogen peroxide-based disinfectant and sterilizing agent comprises the following steps: adding hydrogen peroxide and plant extract into the nano-silver compound, stirring uniformly, adding citric acid to adjust the pH value to 5, and adding water to supplement the solution to 1000 mL.
Example 2
A hydrogen peroxide-based disinfecting sterilant comprising the following raw materials: 15g of nano silver compound; 2mL of hydrogen peroxide; 6g of plant extract; proper amount of citric acid and water are added to 1000 mL.
The preparation method of the nano-silver compound comprises the following steps: (1) sequentially adding 0.10g of glucose, 0.080g of polyvinylpyrrolidone, 0.8g of sodium glutamate and 0.013g of sodium hydroxide into water at the rotating speed of 1000r/min, and stirring until the mixture is transparent and clear; (2) and (3) heating to 60 ℃, adding 5mL of silver nitrate solution (the concentration of the silver nitrate is 0.01mol/L), continuously heating and stirring, and reacting for 6 hours to obtain the nano-silver compound.
The polyvinylpyrrolidone is purchased from Ganbuke New Material science and technology (Shanghai) Co., Ltd, and the product specification is PVPK 30.
The hydrogen peroxide is 35% hydrogen peroxide by mass and is purchased from fine chemical engineering in Rabdosia.
The plant extracts comprise berberine and honeysuckle extracts, and the weight ratio of the berberine to the honeysuckle extracts is 1: 1.3.
the preparation method of the hydrogen peroxide-based disinfectant and sterilizing agent comprises the specific steps of example 1.
Example 3
A hydrogen peroxide-based disinfecting sterilant comprising the following raw materials: 15g of nano silver compound; 2mL of hydrogen peroxide; 6g of plant extract; proper amount of citric acid and water are added to 1000 mL.
The preparation method of the nano-silver compound comprises the following steps: (1) sequentially adding 0.10g of glucose, 0.080g of succinic acid alkyl ester sodium sulfonate, 0.8g of sodium glutamate and 0.013g of sodium hydroxide into water at the rotating speed of 1000r/min, and stirring until the mixture is transparent and clear; (2) and (3) heating to 60 ℃, adding 5mL of silver nitrate solution (the concentration of the silver nitrate is 0.01mol/L), continuously heating and stirring, and reacting for 6 hours to obtain the nano-silver compound.
The alkyl in the succinic acid alkyl ester sodium sulfonate is n-hexyl. The preparation method of the sodium alkyl sulfosuccinate with n-hexyl alkyl comprises the following steps: 1) adding 4mol of maleic anhydride, 2mol of 1, 3-propylene glycol and a solid acid catalyst (the solid acid catalyst is 3 wt% of the maleic anhydride) into a reactor, uniformly stirring, heating to 100 +/-2.5 ℃, and reacting for 5 hours; 2) adding 5mol of n-hexanol into the step 1), uniformly stirring, heating to 200 +/-2.5 ℃, reacting for 4 hours to obtain a mixed solution of a compound 2, and filtering to remove the catalyst; 3) reducing the temperature to 110 +/-2.5 ℃, adding sodium hydroxide in the step 2) to adjust the pH value to 7, then adding 4mol of sodium bisulfite (sodium bisulfite water solution with the mass concentration of 35%) and reacting for 50min to obtain the sodium hydrogen sulfite. Wherein the solid acid catalyst is purchased from south university synthetic chemistry, ltd.
The hydrogen peroxide is 35% hydrogen peroxide by mass and is purchased from fine chemical engineering in Rabdosia.
The plant extracts comprise berberine and honeysuckle extracts, and the weight ratio of the berberine to the honeysuckle extracts is 1: 1.3.
the preparation method of the hydrogen peroxide-based disinfectant and sterilizing agent comprises the specific steps of example 1.
Example 4
The specific implementation mode of the hydrogen peroxide-based disinfection and sterilization agent and the preparation method thereof is the same as that of the embodiment 1, and the differences are that: the plant extract is honeysuckle extract.
Example 5
The specific implementation mode of the hydrogen peroxide-based disinfection and sterilization agent and the preparation method thereof is the same as that of the embodiment 1, and the differences are that: the plant extract is berberine.
Example 6
The specific implementation mode of the hydrogen peroxide-based disinfection and sterilization agent and the preparation method thereof is the same as that of the embodiment 1, and the differences are that: the mass ratio of the polyvinylpyrrolidone to the sodium alkyl succinate sulfonate is 1: 1.
example 7
The specific implementation mode of the hydrogen peroxide-based disinfection and sterilization agent and the preparation method thereof is the same as that of the embodiment 1, and the differences are that: the mass ratio of the polyvinylpyrrolidone to the sodium alkyl succinate sulfonate is 6: 1.
example 8
The specific implementation mode of the hydrogen peroxide-based disinfection and sterilization agent and the preparation method thereof is the same as that of the embodiment 1, and the differences are that: the alkyl in the succinic acid alkyl ester sodium sulfonate is n-undecyl. The preparation method of the sodium sulfosuccinate alkyl ester with the alkyl group being n-undecyl comprises the following steps: 1) adding 4mol of maleic anhydride, 2mol of 1, 3-propylene glycol and a solid acid catalyst (the solid acid catalyst is 3 wt% of the maleic anhydride) into a reactor, uniformly stirring, heating to 100 +/-2.5 ℃, and reacting for 5 hours; 2) adding 5mol of 1-undecanol in the step 1), stirring uniformly, heating to 200 +/-2.5 ℃, reacting for 4 hours to obtain a mixed solution of a compound 2, and filtering to remove the catalyst; 3) reducing the temperature to 110 +/-2.5 ℃, adding sodium hydroxide in the step 2) to adjust the pH value to 7, then adding 4mol of sodium bisulfite (sodium bisulfite water solution with the mass concentration of 35%) and reacting for 50min to obtain the sodium hydrogen sulfite. Wherein the solid acid catalyst is purchased from south university synthetic chemistry, ltd.
Example 9
The specific implementation mode of the hydrogen peroxide-based disinfection and sterilization agent and the preparation method thereof is the same as that of the embodiment 1, and the differences are that: the alkyl in the succinic acid alkyl ester sodium sulfonate is n-propyl. The preparation method of the succinic acid alkyl ester sodium sulfonate with the alkyl group being n-propyl comprises the following steps: 1) adding 4mol of maleic anhydride, 2mol of 1, 3-propylene glycol and a solid acid catalyst (the solid acid catalyst is 3 wt% of the maleic anhydride) into a reactor, uniformly stirring, heating to 100 +/-2.5 ℃, and reacting for 5 hours; 2) adding 5mol of n-propanol into the step 1), uniformly stirring, heating to 200 +/-2.5 ℃, reacting for 4 hours to obtain a mixed solution of a compound 2, and filtering to remove the catalyst; 3) reducing the temperature to 110 +/-2.5 ℃, adding sodium hydroxide in the step 2) to adjust the pH value to 7, then adding 4mol of sodium bisulfite (sodium bisulfite water solution with the mass concentration of 35%) and reacting for 50min to obtain the sodium hydrogen sulfite. Wherein the solid acid catalyst is purchased from south university synthetic chemistry, ltd.
Example 9
The specific implementation mode of the hydrogen peroxide-based disinfection and sterilization agent and the preparation method thereof is the same as that of the embodiment 1, and the differences are that: polyvinylpyrrolidone was replaced with a vinylpyrrolidone-styrene polymer having a CAS number of 25086-29-7.
Performance testing
Antibacterial property: escherichia coli and staphylococcus aureus are used as tested strains, antibacterial performance of the bactericide prepared in different embodiments is inspected through a bacteriostatic ring antibacterial test method, and the specific operation is as follows: 0.1ml of test suspension (10) was aspirated7cfu/ml) is placed in a plate containing nutrient agar, a cotton swab is used for uniformly smearing, then 20ul of bactericide to be tested is dripped on the surface of a culture medium coated with the bacteria to be tested, the culture medium is covered and inverted and is cultured in a 37 ℃ incubator for 10 hours, and the size of the bacteria inhibiting ring is observed.
And (3) testing the inhibition zone: according to the judgment standard of the diameter of the inhibition zone, the diameter of not less than 15mm is highly sensitive, the diameter of not less than 10mm is less than 15mm is moderately sensitive, the diameter of less than 10mm is lowly sensitive, and the larger the diameter is, the stronger the antibacterial activity is.
And (3) placing the sterilizing agent described in the example at 50 ℃ for 72 hours, observing the appearance of the sterilizing agent, testing the absorbance value of the nano Ag by using an ultraviolet spectrophotometer, and calculating the absorbance decrease rate, wherein the absorbance decrease rate (the absorbance just after the preparation is carried out and the absorbance after the placing is carried out for 72 hours) is × 100/the absorbance just after the preparation is carried out, wherein the absorbance decrease rate is less than 5% and is recorded as excellent, more than 5% and less than 20% are recorded as medium, and more than 20% is recorded as poor.
Figure BDA0002475956720000111
The disinfectant and sterilizing agent meets the relevant requirements of disinfection technical specification in other aspects.
The above description is only a preferred embodiment of the present invention, and is not intended to limit the present invention in other forms, and any person skilled in the art may modify or change the technical content of the above disclosure into equivalent embodiments with equivalent changes, but all those simple modifications, equivalent changes and modifications made to the above embodiments according to the technical spirit of the present invention still belong to the protection scope of the present invention.

Claims (10)

1. A hydrogen peroxide-based disinfecting sterilant, characterized by the raw materials comprising: 10-20g of nano silver compound; 1-3mL of hydrogen peroxide; 3-8g of plant extract; supplementing water to 1000 mL; wherein the plant extract is at least one selected from berberine, flos Lonicerae extract, green tea extract, and radix Sophorae Flavescentis extract.
2. A sterilizer as defined in claim 1 wherein the nanosilver composite is prepared from: glucose, lactam-containing polymers and/or sodium alkyl sulfosuccinate, silver salts.
3. A sterilizer as defined in claim 2 wherein the lactam-based polymer has a lactam-based dipole moment in the range of 30 to 42.
4. A sterilizer as claimed in claim 2 or claim 3 wherein the lactam group of the lactam-group containing polymer is a butyrolactam group.
5. A sterilizer as claimed in claim 3 or claim 4 wherein the lactam-group containing polymer further comprises methylene groups in the long chain, the lactam groups of the lactam-group containing polymer are not in the same environment as the two ends of the lactam group, the oxygen atom end is exposed and the N atom end is surrounded by methyl and methylene groups.
6. A sterilizer as claimed in claim 5, wherein the lactam-group containing polymer has a viscosity (mPa.s/25 ℃/5% aq) in the range of 1.1 to 2.7 and a number average molecular weight of 10000-.
7. A sterilizer as claimed in claim 6, wherein the mass ratio of lactam-containing polymer to sodium alkyl sulfosuccinate is (2-4): 1.
8. a sterilizer as set forth in claim 7 wherein the alkyl group of said sodium sulfosuccinate is at least one selected from the group consisting of ethyl, propyl, isopropyl, n-butyl, isobutyl, sec-butyl, tert-butyl, n-pentyl, isopentyl, sec-pentyl, tert-pentyl, n-hexyl, isohexyl, n-octyl, and isooctyl.
9. A sanitizer according to claim 1, wherein said starting materials further comprise a pH adjuster.
10. A method of preparing a sanitizer according to claim 9, comprising the steps of: adding hydrogen peroxide and plant extract into the nano-silver compound, stirring uniformly, adding a pH regulator and adding water to supplement to 1000 mL.
CN202010364003.9A 2020-04-30 2020-04-30 Hydrogen peroxide-based disinfection sterilizing agent and preparation method thereof Withdrawn CN111374149A (en)

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112741116A (en) * 2021-01-15 2021-05-04 四川恒博生物科技有限公司 Silver ion composite disinfection and sterilization sporicide based on hydrogen peroxide
CN113966741A (en) * 2021-12-10 2022-01-25 西安文理学院 Efficient and environment-friendly bactericide

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112741116A (en) * 2021-01-15 2021-05-04 四川恒博生物科技有限公司 Silver ion composite disinfection and sterilization sporicide based on hydrogen peroxide
CN113966741A (en) * 2021-12-10 2022-01-25 西安文理学院 Efficient and environment-friendly bactericide

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