CN111374136A

CN111374136A - Composition of pymetrozine and thiamethoxam and preparation method and application thereof

Info

Publication number: CN111374136A
Application number: CN202010232731.4A
Authority: CN
Inventors: 孝杰; 纪乐光; 张霞; 臧迎歌; 徐磊
Original assignee: Shandong Lvshi Pesticide Co ltd
Current assignee: Shandong Lvshi Pesticide Co ltd
Priority date: 2020-03-28
Filing date: 2020-03-28
Publication date: 2020-07-07

Abstract

The invention discloses a composition of pymetrozine and thiamethoxam, which comprises the following components in parts by weight: 23.6-26 parts of pymetrozine, 9.4-11.2 parts of thiamethoxam, 0.355-0.395 part of camptothecin, 3.02-3.32 parts of alkylphenol polyoxyethylene, 1-1.2 parts of sodium dodecyl sulfate, 0.003-0.007 part of magnesium stearate, 0.2-0.3 part of citric acid and 45-59 parts of deionized water. The invention also discloses a preparation method of the composition of pymetrozine and thiamethoxam, which has the advantage of improving the dispersion uniformity of the water dispersible granules. In addition, the application of the composition is also disclosed, and the composition can be used for preventing and controlling rice planthoppers and has the advantage of improving the pesticide effect.

Description

Composition of pymetrozine and thiamethoxam and preparation method and application thereof

Technical Field

The invention relates to the field of pesticides, in particular to a composition of pymetrozine and thiamethoxam, a preparation method and application thereof.

Background

Pymetrozine belongs to pyridine or triazone insecticides, is a brand-new non-biocidal insecticide, and has contact poisoning effect on pests and systemic activity. Can be transported in the xylem and phloem of the plant body; therefore, the fertilizer can be used for foliar spraying and soil treatment. Due to the good transmission and conduction characteristics, branches and leaves newly grown after stem and leaf spraying can be effectively protected.

Thiamethoxam is a second generation nicotine high-efficiency low-toxicity pesticide with a brand-new structure, has stomach toxicity, contact killing and systemic activity on pests, and is used for leaf surface spraying and soil root irrigation treatment.

In the prior art, as in chinese patent publication No. CN103329925A, a water dispersible granule of thiamethoxam and pymetrozine composite pesticide is provided, which is prepared from the following components in parts by weight: thiamethoxam: 15 parts of pymetrozine: 60 parts of auxiliary agent 15 parts, and filler: 10 parts of water: not more than 5 parts.

Because the breeding rate of pests is high, when the thiamethoxam and pymetrozine composite pesticide in the technical scheme is used for preventing and controlling the pests, the number of the pests is reduced within a period of time after the pesticide is used, but the number of the pests is greatly increased along with the time lapse, so that how to further improve the pesticide effect duration of the pesticide is an urgent problem to be solved.

Disclosure of Invention

Aiming at the defects in the prior art, the first purpose of the invention is to provide a composition of pymetrozine and thiamethoxam, which has the advantage of improving the pesticide effect duration of the composition of thiamethoxam and pymetrozine.

The second purpose of the invention is to provide a preparation method of the composition of pymetrozine and thiamethoxam, which has the advantage of improving the dispersion uniformity of the water dispersible granules.

The third purpose of the invention is to provide the application of the composition of pymetrozine and thiamethoxam, which has the advantage of preventing and controlling rice planthoppers.

In order to achieve the first object, the invention provides the following technical scheme: comprises the following components in parts by weight: 23.6-26 parts of pymetrozine, 9.4-11.2 parts of thiamethoxam, 0.355-0.395 part of camptothecin, 3.02-3.32 parts of alkylphenol polyoxyethylene, 1-1.2 parts of sodium dodecyl sulfate, 0.003-0.007 part of magnesium stearate, 0.2-0.3 part of citric acid and 45-59 parts of deionized water.

By adopting the technical scheme, the pest which takes in the pesticide generates antifeedant reaction due to the addition of the pymetrozine, so that the pest is starved, the pest which takes in the pesticide is excessively excited due to the addition of the thiamethoxam, so that the pest dies, and the added camptothecin enables the pest not to lay eggs or generate variant eggs which cannot grow, so that the pest which takes in the thiamethoxam and the pymetrozine and generates pesticide resistance cannot be killed and cannot transmit the pesticide resistance to the next generation of pest, and the purpose of improving the pesticide effect duration of the composition is realized through the compounding of the thiamethoxam, the pymetrozine and the camptothecin; the macromolecular chain of alkylphenol ethoxylates is utilized to increase the steric effect between particles, so that after pymetrozine, thiamethoxam and camptothecin are dissolved in water, solid particles are not prone to sedimentation and agglomeration, and the uniform dispersion of the solid particles of the composition in water is improved. The sodium dodecyl sulfate is added and then adsorbed on the surface of the solid particles, so that the surface tension of the solid particles is reduced, the solid particles of the composition are more easily wetted by water, and the uniform dispersion of the solid particles of the composition in the water is further promoted; after substances such as a dispersing agent, a wetting agent and the like are added into deionized water, foam is easily generated in the mixing process of the mixture, so that the mixing uniformity of the mixture is influenced, therefore, a defoaming agent is added to reduce the influence of the foam in the mixture, and the addition of citric acid is used for adjusting the pH value so that the thiamethoxam and the pymetrozine stably exist in the deionized water.

Further, the weight portion of the pymetrozine is 24.8 portions.

Further, the weight part of the thiamethoxam is 10.3 parts.

Further, the solid-to-liquid ratio of the composition was 45: 55.

By adopting the technical scheme, experiments prove that when the solid-to-liquid ratio of the composition is too large, the stirring time of the composition is prolonged due to too large consistency of the composition; when the solid-to-liquid ratio of the composition is too small, the composition is stirred for a short time due to too small consistency of the composition, but the composition granulation time is not changed, so that the amount of granulation of the composition is reduced, thereby causing reduction in production efficiency of the composition.

Further, the composition also comprises 4.8-5.2 parts of carbaryl.

By adopting the technical scheme, acetylcholine for transmitting excitation exists in a pest body, after the acetylcholine acts on an acetylcholine receptor, the excitation is transmitted to the receptor, the acetylcholine can be decomposed by acetylcholinesterase, the thiamethoxam acts on the acetylcholine receptor of the pest, and is not easily decomposed by acetylcholinesterase, so that the pest is continuously excited until death, and the methylnecrocarb acts on the acetylcholinesterase, so that the acetylcholine is not easily decomposed by the acetylcholinesterase, and the pest is further excited to accelerate the death of the pest.

In order to achieve the second object, the invention provides the following technical scheme:

a preparation method of a composition of pymetrozine and thiamethoxam is characterized by comprising the following steps:

step 1: weighing alkylphenol polyoxyethylene, sodium dodecyl sulfate, magnesium stearate, citric acid, deionized water, pymetrozine, thiamethoxam and camptothecin according to parts by mass;

step 2: adding the weighed deionized water into a stirring tank;

and step 3: adding the weighed alkylphenol polyoxyethylene, sodium dodecyl sulfate, magnesium stearate and citric acid into a stirring tank;

and 4, step 4: adding the weighed pymetrozine, thiamethoxam and camptothecin into a stirring tank, uniformly stirring at a stirring speed of 180r/min to prepare a feed liquid, and then shearing and dispersing the feed liquid;

and 5: sanding the feed liquid at the rotating speed of 800r/min until the particle size D90=5.3 μm;

step 6: and (4) collecting the feed liquid, controlling the pressure to be 2.5MPa, and performing spray granulation to obtain the product.

By adopting the technical scheme, the materials are uniformly stirred by the stirrer and then dispersed by the dispersion machine, so that the residual large-particle substances are further crushed by the dispersion machine during stirring, and the aim of improving the dispersion uniformity of the materials is fulfilled; the two sand mills sand the material, so that the particle size of the material is further reduced, and the aim of improving the dispersion uniformity of the composition is fulfilled.

step 1: weighing pymetrozine, thiamethoxam, camptothecin, alkylphenol ethoxylates, sodium dodecyl sulfate, magnesium stearate, citric acid and deionized water according to parts by mass;

step 2: adding the weighed deionized water into a stirring tank;

and 4, step 4: adding the weighed pymetrozine, thiamethoxam, camptothecin and carbaryl into a stirring tank, uniformly stirring at a stirring speed of 180r/min to prepare a feed liquid, and then shearing and dispersing the feed liquid;

In order to achieve the third object, the invention provides the following technical solutions:

an application of a composition of pymetrozine and thiamethoxam in preventing and treating rice planthopper.

By adopting the technical scheme, the method has the advantages that,

in conclusion, the invention has the following beneficial effects:

firstly, the pest which intakes the pesticide generates a food refusal reaction by adding pymetrozine, so that the pest is starved, the pest which intakes the pesticide is excessively excited by adding thiamethoxam, so that the pest dies, and the pest which intakes the pesticide cannot lay eggs or generate variant eggs which cannot grow, so that the pest which intakes the thiamethoxam and pymetrozine and generates pesticide resistance cannot be killed and can not transmit the pesticide resistance to next generation of pests.

Secondly, in the invention, the material is preferably further sheared by a high-speed dispersion machine after being uniformly stirred by a stirrer, so that large-particle substances in the stirred material are further reduced, and the aim of improving the mixing uniformity of the composition is fulfilled.

Detailed Description

The present invention will be described in further detail with reference to examples.

The starting materials used in the examples are all commercially available. Wherein pymetrozine (98%) and thiamethoxam (98%) are obtained from Shanghai city, Wuhan science and technology development, Inc., camptothecin (97%) is obtained from Shanghai Mielin biochemistry technology, Inc., Kaempferi is obtained from Shanghai Vast Bio-technology, Inc., and alkylphenol ethoxylates is obtained from Aike reagent and adopts APE-50.

Examples

Example 1

Step 1: weighing 24.8g of pymetrozine, 10.3g of thiamethoxam, 0.375g of camptothecin, 3.17g of alkylphenol polyoxyethylene, 1.1g of sodium dodecyl sulfate, 0.005g of magnesium stearate, 0.25g of citric acid and 52g of deionized water;

step 2: adding the deionized water weighed in the step one into a stirring tank;

and step 3: adding the sodium dodecyl sulfate, the alkylphenol ethoxylates, the magnesium stearate and the citric acid weighed in the step one into a stirring tank;

and 4, step 4: adding the pymetrozine, the thiamethoxam and the camptothecin weighed in the step one into a stirring tank, uniformly stirring at a stirring speed of 180r/min, recording the stirring time to prepare a feed liquid, and then shearing and dispersing the feed liquid at a speed of 1500r/min for 25 minutes;

and 5: the feed liquid prepared in the step four passes through two sand mills connected in series, the rotating speed of the sand mills is adjusted to 800r/min, and the sand milling is carried out on the feed liquid until the grain diameter D90=5.3 μm;

step 6: and (5) collecting the feed liquid obtained in the step five, controlling the pressure to be 2.5MPa, and performing spray granulation to obtain the product.

Example 2

Example 2 differs from example 1 in that: and (3) 23.6g of pymetrozine in the step 1, and stirring time does not need to be recorded.

Example 3

Example 3 differs from example 1 in that: 26g of pymetrozine in the step 1, and stirring time does not need to be recorded.

Example 4

Example 4 differs from example 1 in that: in the step 1, 9.4g of thiamethoxam is used, and the stirring time is not required to be recorded.

Example 5

Example 5 differs from example 1 in that: 11.2g of thiamethoxam in the step 1, and stirring time does not need to be recorded.

Example 6

Example 6 differs from example 1 in that: step 1, camptothecin 0.355g, no stirring time was recorded.

Example 7

Example 7 differs from example 1 in that: camptothecin 0.395g in step 1, no stirring time was recorded.

Example 8

Example 8 differs from example 1 in that: 3.02g of alkylphenol polyoxyethylene in the step 1, and stirring time does not need to be recorded.

Example 9

Example 9 differs from example 1 in that: in the step 1, 3.32g of alkylphenol polyoxyethylene ether is used, and the stirring time is not required to be recorded.

Example 10

Example 10 differs from example 1 in that: in the step 2, 1g of sodium dodecyl sulfate is used, and the stirring time is not required to be recorded.

Example 11

Example 11 differs from example 1 in that: in step 2, 1.2g of sodium dodecyl sulfate is used, and the stirring time is not required to be recorded.

Example 12

Example 12 differs from example 1 in that: magnesium stearate 0.003g in step 2, no stirring time has to be recorded.

Example 13

Example 13 differs from example 1 in that: magnesium stearate 0.007g in step 2, no stirring time need be recorded.

Example 14

Example 14 differs from example 1 in that: 0.2g of citric acid in step 2, without recording the stirring time.

Example 15

Example 15 differs from example 1 in that: 0.3g of citric acid in step 2, without recording the stirring time.

Example 16

Example 16 differs from example 1 in that: 45g of deionized water in step 1, and the stirring time was recorded.

Example 17

Example 17 differs from example 1 in that: 59g of deionized water in step 1 and the stirring time was recorded.

Example 18

Step 1: weighing 24.8g of pymetrozine, 10.3g of thiamethoxam, 0.375g of camptothecin, 3.17g of alkylphenol polyoxyethylene, 1.1g of sodium dodecyl sulfate, 0.005g of magnesium stearate, 0.25g of citric acid and 48.9g of deionized water;

Example 19

Step 1: weighing 24.8g of pymetrozine, 10.3g of thiamethoxam, 0.375g of camptothecin, 5g of carbaryl, 3.17g of alkylphenol ethoxylates, 1.1g of sodium dodecyl sulfate, 0.005g of magnesium stearate, 0.25g of citric acid and 52g of deionized water;

and 4, step 4: adding the pymetrozine, the thiamethoxam, the camptothecin and the carbaryl weighed in the step one into a stirring tank, uniformly stirring at a stirring speed of 180r/min, recording the stirring time to prepare a feed liquid, and shearing and dispersing the feed liquid at a speed of 1500r/min for 25 minutes;

Example 20

Example 20 differs from example 19 in that: in step 1, 5.2g of carbaryl, the stirring time is not required to be recorded.

Example 21

Example 21 differs from example 19 in that: in step 1, 4.8g of carbaryl does not need to record the stirring time.

Example 22

Example 22 differs from example 19 in that: step 1 deionized water 55g, stirring time was not recorded.

Comparative example

Comparative example 1

Step 1: weighing 24.8g of pymetrozine, 10.3g of thiamethoxam, 5g of carbaryl, 3.17g of alkylphenol polyoxyethylene, 1.1g of sodium dodecyl sulfate, 0.005g of magnesium stearate, 0.25g of citric acid and 52g of deionized water;

and 4, step 4: adding the pymetrozine, the thiamethoxam and the tenerb weighed in the step one into a stirring tank, uniformly stirring at a stirring speed of 180r/min to prepare a feed liquid, and then shearing and dispersing the feed liquid for 25 minutes;

Performance test

The performance test was carried out for example 1 to comparative example 1 according to the test method of standard Q/371425SLN, and the results are shown in Table 1.

Table 1 table of performance testing data

As can be seen from the first to third examples in Table 1, the indexes of the composition are better when 24.8g of pymetrozine is used than when 23.6g and 26g of pymetrozine are used.

As can be seen from the first embodiment, the fourth embodiment and the fifth embodiment in the table 1, when the thiamethoxam is used for 10.3g, the indexes of the composition are better than those when the thiamethoxam is used for 9.4g and 26 g.

TABLE 2 stirring time recording sheet

Examples	Example 1	Example 16	Example 17	Example 18
					Solid-to-liquid ratio	42.3:55	48.9:55	37.3:55	45:55
Stirring time/s	13	26	14	16

As can be seen from Table 2, when the solid-to-liquid ratio is greater than 45:55, the stirring of the feed liquid is laborious due to the excessive viscosity of the feed liquid, so that the stirring time of the feed liquid is prolonged;

when the solid-liquid ratio is less than 45:55, the solid content in the feed liquid is too low, so that the dosage of the medicament generated by the feed liquid is too small, and the stirring time is prolonged because the feed liquid with small solid-liquid ratio is used for producing the medicament with the same dosage.

The composition of pymetrozine and thiamethoxam in the embodiment 22 and the comparative example 1 is used for a laboratory test for controlling rice planthopper, 80% of thiacloprid and pymetrozine with the registration number of PD20172196 is used as a contrast reagent, and the test steps are as follows:

the method comprises the following steps: three groups of medicaments are prepared into aqueous solutions according to the proportion of 3g/25L, and are divided into three groups, namely the medicaments in the embodiment 22: test 1, test 2, test 3, agent of comparative example 1: run 4, run 5, run 6, run 80% of thidiazuron pymetrozine: test 7, test 8, test 9;

step two: preparing 9 feeding boxes, controlling the feeding boxes to have the same factors such as temperature and humidity, preparing 10000 adult rice planthoppers in each feeding box, and spraying the rice planthoppers in the 9 feeding boxes by using the medicaments in the tests 1 to 9;

step three: recording the number of the remaining rice planthoppers in each group of the test after one day;

step four: recording the number of the remaining rice planthoppers in each group of the test after one week;

step five: after one month interval, the number of remaining rice planthoppers per group tested was recorded.

TABLE 3 statistical table of rice planthopper number

As can be seen from the data in table 3, after three groups of agents are used to respectively test rice planthoppers, the test results of the three agents are similar after one day interval, and the test results of the three agents are similar after one week interval, but after one month interval, the survival number of the rice planthoppers in example 22 is far less than that of the rice planthoppers with the thiacloprid and pymetrozine of comparative example 1 and 80%, so that the pesticide effect duration of the composition of the pymetrozine and the thiamethoxam can be obviously improved by adding the camptothecin.

The present embodiment is only for explaining the present invention, and it is not limited to the present invention, and those skilled in the art can make modifications of the present embodiment without inventive contribution as needed after reading the present specification, but all of them are protected by patent law within the scope of the claims of the present invention.

Claims

1. The composition of pymetrozine and thiamethoxam is characterized by comprising the following components in parts by weight: 23.6-26 parts of pymetrozine, 9.4-11.2 parts of thiamethoxam, 0.355-0.395 part of camptothecin, 3.02-3.32 parts of alkylphenol polyoxyethylene, 1-1.2 parts of sodium dodecyl sulfate, 0.003-0.007 part of magnesium stearate, 0.2-0.3 part of citric acid and 45-59 parts of deionized water.

2. A composition of pymetrozine and thiamethoxam according to claim 1, wherein the part by weight of pymetrozine is 24.8 parts.

3. A composition of pymetrozine and thiamethoxam according to claim 2, wherein the thiamethoxam is present in an amount of 10.3 parts by weight.

4. The composition of pymetrozine and thiamethoxam according to claim 1, wherein the solid-to-liquid ratio of the composition is 45: 55.

5. The composition of pymetrozine and thiamethoxam according to claim 1, further comprising 4.8-5.2 parts of methylencarb.

6. A process for the preparation of a composition of pymetrozine and thiamethoxam, according to any one of claims 1 to 4, which comprises the steps of:

step 2: adding the weighed deionized water into a stirring tank;

and 4, step 4: adding the weighed pymetrozine, thiamethoxam and camptothecin into a stirring tank, uniformly stirring at a stirring speed of 180r/min to prepare a feed liquid, and shearing and dispersing the feed liquid at a speed of 1500 r/min;

7. The method for preparing the composition of pymetrozine and thiamethoxam according to claim 5, which comprises the following steps:

step 2: adding the weighed deionized water into a stirring tank;

and 4, step 4: adding the weighed pymetrozine, thiamethoxam, camptothecin and carbaryl into a stirring tank, uniformly stirring at a stirring speed of 180r/min to prepare a feed liquid, and then shearing and dispersing the feed liquid at a speed of 1500 r/min;

8. The application of the composition of pymetrozine and thiamethoxam is characterized in that the composition is used for controlling rice planthoppers.