CN111358502B - Biological reaction control state capsule suitable for animals and humans - Google Patents
Biological reaction control state capsule suitable for animals and humans Download PDFInfo
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- CN111358502B CN111358502B CN202010166965.3A CN202010166965A CN111358502B CN 111358502 B CN111358502 B CN 111358502B CN 202010166965 A CN202010166965 A CN 202010166965A CN 111358502 B CN111358502 B CN 111358502B
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B10/00—Other methods or instruments for diagnosis, e.g. instruments for taking a cell sample, for biopsy, for vaccination diagnosis; Sex determination; Ovulation-period determination; Throat striking implements
- A61B10/02—Instruments for taking cell samples or for biopsy
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4816—Wall or shell material
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Abstract
The invention discloses a biological reaction control state capsule suitable for animals and humans, which comprises a capsule shell, wherein a plurality of one-way valves are embedded on the surface of the capsule shell, the inner wall of the capsule shell is provided with a capsule wall, the inner wall of the capsule shell below the one-way valves is connected with absorption fibers, the inside of the capsule shell is filled with carbon dioxide, the bottom end of the capsule shell is provided with a plurality of elastic balls, at least one-way valve is arranged, the one-way valves can be a positive pressure valve and a negative pressure valve, the invention realizes pressure difference through fermentation reaction of microorganism, growth of organism, water absorption expansion of protein/cellulose and other nontoxic substances to human body or preset chemical reaction related to pressure in human body, thereby facilitating opening of a one-way valve of the capsule, realizing sampling, absorption and storage of flora, controlling reaction rate of gel, realizing extraction of flora at different positions, and facilitating medical research.
Description
Technical Field
The invention relates to the technical field of medical treatment, in particular to a biological reaction control state capsule suitable for animals and humans.
Background
A large number of symbiotic bacteria groups exist in human intestinal tracts, the number of the symbiotic bacteria groups exceeds 1000 trillion and is about 10 times of the total number of human cells, meanwhile, the number of microbial genes in the intestinal tracts is about 300 ten thousand and is about 100 times of the number of human genome genes, so that the massive genes can help microorganisms adapt to changeable environments, an inseparable symbiotic relation with human bodies is formed,
the microbial community in the intestinal tract of a human body has very close relation with a host, can not only generate short-chain fatty acid, vitamin K and other nutritional substances which cannot be generated by the human body and have positive significance to health, but also promote differentiation and maturation of intestinal epithelial cells of the host, can regulate energy storage and metabolism of the host and activate intestinal immune systems of the host, so that the effect of intestinal flora on the human body can be summarized into three aspects of nutrition metabolism, immunoregulation and protection;
the entity of the interaction and influence of intestinal flora and human body is called as the trace microecology (gut microeffora), which is the largest microecological system of human body and is closely related to the health and diseases of human beings, and a great deal of researches and evidence have been presented in the past decade that intestinal microecology can regulate the brain functions, and along with the proposal and demonstration of the axis theory of brain-intestinal flora, the related researches of microecology have been related to hypertension, diabetes, intestinal diseases, obesity, cancers and central nervous system diseases;
to study the intestinal flora, the sampling device is an ideal tool for achieving the object, and further, the action of the sampling device far exceeds the requirement and the requirement of human intestinal sampling, so that the sampling device is not only significant for the distribution of intestinal microorganisms, but also the respective byproducts, the interaction among them, and intestinal secretions, poisons, tumor cells, tumor products and the like, and the direct acquisition of flora samples through human bodies is of great importance and indispensable importance.
Research related at home and abroad, patent of Li Huifeng et al: the intestinal content negative pressure automatic sampler (patent number 201711255713.2) sets the negative pressure in the capsule, and the switch for triggering sampling is sealed by a specific membrane which can be dissolved at the stomach, duodenum and jejunum, and the sampling is performed after the sealing membrane is dissolved. In the united states, precious nacin, fluid sampling devices (patent No. 201780051676.5), electrodes are covered with PH sensors, or with different intestine section soluble colloids, and the electrodes are electrically controlled on and off after dissolution to sample. The devices rely on the pH change of the intestinal section or the dissolution of the intestinal section to specific compounds to trigger sampling, the triggering points all face the problems of incomplete segmentation, inaccurate positioning, incomplete sampling, and a microprocessor and mechanical control are additionally used, so that a series of problems of potential battery pollution, high cost, repeated use, psychological discomfort of people and the like are necessarily brought.
Disclosure of Invention
The invention provides a biological reaction control state capsule suitable for animals and people, which can effectively solve a series of problems caused by the sampling of an electromechanical capsule triggered by the change of a PH value or the change of the capability of a digestive membrane in the background technology.
In order to achieve the above purpose, the present invention provides the following technical solutions: a biological reaction control state capsule suitable for animals and humans comprises a capsule shell, wherein a plurality of one-way valves are embedded on the surface of the capsule shell.
According to the above technical scheme, one, two or more components are used for controlling pressure change through physical or chemical reaction or biological growth.
According to the above technical solution, one component is extruded through the gastrointestinal tract to cause the property change and then the pressure change, two or more components are packed in groups, the packing breaks to react after extrusion of gastrointestinal movement, or one component participating in the reaction is gastrointestinal contents.
According to the technical scheme, the reaction speed is controlled by wrapping a plurality of microcapsules by the components, wherein each microcapsule has different wall thickness or different components and structures, and the reaction speed is controlled by different rupture speeds under the extrusion of gastrointestinal movement, or the reaction speed is controlled by controlling the permeability of films with different thicknesses so as to control the speed of intestinal contents entering the capsule.
According to the technical scheme, the partial area of the capsule shell is provided with the special capsule wall, the special capsule wall is made of the polymer material doped with the water absorbing substance, the water absorbing substance can be cellulose, protein or other materials capable of forming capillary water absorbing phenomenon, the thickness of the capsule wall, the quantity of the doped water absorbing substance, the doping mode and the doping process can influence the water absorbing speed, the water absorbing speed of the capsule wall of the doped water absorbing substance determines the speed of water entering the capsule shell, and the reaction time and the reaction speed of water serving as reactants are determined.
According to the technical scheme, 1 water-swelling substance or growth-swelling substance or 2 or more substances which can react when meeting water can be placed in the capsule shell or on the inner wall of the capsule shell, and the pressure change can be caused by the reaction.
According to the above technical scheme, preferably, the inner wall of the capsule shell is provided with a special capsule wall, the water-absorbing fiber in the special capsule wall absorbs water at a certain speed, the inside of the capsule shell is filled with carbon dioxide, the capsule wall is coated with a mixture of alkaline substances and gum substances, and the cellulose capillary water absorption speed determines the reaction speed of the alkaline substances and the carbon dioxide on the capsule wall and determines the speed of air pressure reduction.
According to the technical scheme, the gel is partially enclosed on the outer wall of the capsule shell, the reaction speed is determined by the permeation speed of the gel, and enzyme molecules can be contained in the gel.
According to the above technical scheme, the enzyme molecule refers to an enzyme capable of decomposing the whole or partial structure of the gel.
According to the above technical scheme, the water-absorbing substance, the water-swelling substance and the gel partially surrounded by the outer wall of the capsule shell mainly comprise natural hydrophilic products and synthetic water-absorbing polymers, including but not limited to celluloses, proteins, starches, agarose, acrylics, polyvinyl alcohol, polyvinylpyrrolidone, gelatin, sodium alginate, casein, guar gum, chitosan, gum arabic, xanthan gum, soy protein gum, natural rubber, lanolin, agar polyacrylamide, polyvinyl alcohol, polyvinylpyrrolidone, polyethylene oxide, carbomer resin, polyacrylic acid, sodium polyacrylate, polyacrylate copolymer emulsion, butadiene rubber, styrene butadiene rubber, polyurethane, modified polyurea, low molecular polyethylene wax and amino alcohol complex titanate.
According to the technical scheme, at least one-way valve is arranged, the one-way valves can be positive pressure valves and negative pressure valves, the elastic ball is uneven, and the number of the elastic balls is two.
According to the technical scheme, the one-way valve comprises two spring clamping pieces, and the two spring clamping pieces are in contact sealing through the clamping blocks.
According to the technical scheme, four clamping blocks are arranged in the one-way valve, wherein two clamping blocks are connected with the capsule shell through spring clamping blocks, are installed in parallel and are connected with the capsule shell through rubber bands;
the clamping block is triangular, the capsule shell is arc-shaped, and the one-way valve is wide-mouth.
Compared with the prior art, the invention has the beneficial effects that: the invention has scientific and reasonable structure and safe and convenient use, realizes pressure difference through fermentation reaction of microorganisms, growth of organisms, water absorption expansion of protein/cellulose and other non-toxic substances to human bodies or preset chemical reaction related to pressure in human bodies, thereby facilitating opening of a one-way valve of the capsule, realizing sampling, absorption and storage of flora, controlling reaction rate of gel, realizing extraction of flora at different positions and facilitating medical research.
Drawings
The accompanying drawings are included to provide a further understanding of the invention and are incorporated in and constitute a part of this specification, illustrate the invention and together with the embodiments of the invention, serve to explain the invention.
In the drawings:
FIG. 1 is a schematic diagram of the structure of the present invention;
FIG. 2 is a schematic diagram of the connection relationship of the capsule wall, gel and capsule shell;
FIG. 3 is a schematic diagram of the connection relationship between the spring clip and the clip according to the present invention;
FIG. 4 is a schematic diagram of the connection relationship among the spring clip, the clip block and the rubber band;
reference numerals in the drawings: 1. a capsule housing; 2. a one-way valve; 3. a capsule wall; 4. an absorbent fiber; 5. carbon dioxide; 6. a spring ball; 7. a spring card; 8. a clamping block; 9. an elastic band; 10. and (5) gel.
Detailed Description
The preferred embodiments of the present invention will be described below with reference to the accompanying drawings, it being understood that the preferred embodiments described herein are for illustration and explanation of the present invention only, and are not intended to limit the present invention.
Example 1: as shown in fig. 1-2, the invention provides a technical scheme, namely a biological reaction control state capsule suitable for animals and humans, which comprises a capsule shell 1, wherein a plurality of one-way valves 2 are embedded on the surface of the capsule shell 1, the capsule shell 1 is arc-shaped, the one-way valves 2 are at least one in wide-mouth production, and the one-way valves 2 can be positive pressure and negative pressure valves, so that the capsule is convenient for different environments to use, and is convenient for the discharge and absorption of medicines and bacterial groups;
the method for controlling the reaction speed comprises the steps of coating a plurality of capsules by the components, wherein the capsules are different in wall thickness, so that the rupture speed is different, and the reaction speed is controlled.
The scheme can be adopted: one group of the coating inner sealing carbonate substances and the other group of the coating inner sealing carbonate substances are directly put into acid substances, the coating thickness is controlled, and series of capsules are made according to different thicknesses of the microcapsules which are coated inside; after the sampling capsule is orally taken into human gastrointestinal tract, the microcapsule is broken under the extrusion action of gastrointestinal movement for a certain period of time, and acid and carbonate react to produce carbon dioxide, so that the pressure in the capsule is raised and the one-way valve is opened. Subsequently, during gastrointestinal motility, the substances within the gastrointestinal tract are pressed into the capsule. After substances in the gastrointestinal tract enter the capsule, the water can dissolve the spring card fixing glue, the fixing glue is composed of glue substances which are easy to absorb water, such as carrageenan, xanthan gum, gelatin and the like, the glue is dissolved, and after softening, the mouth of the capsule is closed under the action of the spring until the capsule is discharged out of the body.
Example 2: as shown in fig. 2-3, the invention provides a technical scheme, namely a biological reaction control state capsule suitable for animals and humans, which comprises a capsule shell 1, wherein a plurality of one-way valves 2 are embedded in the surface of the capsule shell 1, each one-way valve 2 comprises two spring clamping pieces 7, the two spring clamping pieces 7 are in contact sealing through a clamping block 8, the clamping block 8 is triangular, the capsule shell 1 is arc-shaped, the one-way valves 2 are at least one in wide-mouth production, and the one-way valves 2 can be positive pressure and negative pressure valves, so that the capsule is convenient for different environments to use, and the excretion of medicines and the absorption of flora are convenient;
the outer wall of the capsule shell 1 is provided with gel 10, the gel 10 can be gelatin, the water absorption and permeation speed of the gel 10 determines the reaction speed, protease is selected as enzyme molecules in the gel 10, relevant enzymes are added into gel substances, the gel substances can be liquefied quickly under the condition of the ambient temperature of the gastrointestinal tract, and the membrane can be dissolved due to the liquefaction along with the time, so that the valve is opened, and the content in the intestinal tract can be extruded. After the content enters the capsule, the clamping block 8 slowly absorbs water and becomes soft, and is slowly closed under the action of the spring clamping block 7.
Example 3: as shown in fig. 2-3, the invention provides a technical scheme, namely a biological reaction control state capsule suitable for animals and humans, which comprises a capsule shell 1, wherein a plurality of one-way valves 2 are embedded in the surface of the capsule shell 1, each one-way valve 2 comprises two spring clamping pieces 7, the two spring clamping pieces 7 are in contact sealing through a clamping block 8, the clamping block 8 is triangular, the capsule shell 1 is arc-shaped, the one-way valves 2 are at least one in wide-mouth production, and the one-way valves 2 can be positive pressure and negative pressure valves, so that the capsule is convenient for different environments to use, and the excretion of medicines and the absorption of flora are convenient;
the inner wall of the capsule shell 1 is provided with a capsule wall 3, cellulose and other materials which are not digested and can absorb water through capillary phenomenon are pressed into the capsule wall 3, the size and thickness of the material are established, the water absorption speed is determined, the reaction speed, the growth speed and the pressure change speed are determined by the water absorption speed, preferably, dry saccharomycetes and glucose are added into the capsule shell, when moisture enters, the saccharomycetes grow aerobically or anaerobically under the condition of the intestinal environment temperature, carbon dioxide is generated, when the pressure reaches a certain degree, the one-way valve 2 is opened, the content in the intestinal tract can be absorbed, the inner wall of the capsule shell 1 below the one-way valve 2 is connected with the absorption fiber 4, the inside of the capsule shell 1 is filled with the carbon dioxide 5, the bottom end of the capsule shell 1 is provided with a plurality of elastic balls 6, and the elastic balls 6 are provided with two, so that the normal elastic balls can conveniently bounce.
Example 4: as shown in fig. 2 and 4, the invention provides a technical scheme, which is applicable to biological reaction control state capsules of animals and humans, and comprises a capsule shell 1, wherein a plurality of one-way valves 2 are embedded in the surface of the capsule shell 1, four clamping blocks 8 are arranged in the one-way valves 2, wherein two clamping blocks 8 are connected with the capsule shell 1 through spring clamping blocks 7, the two clamping blocks 8 are installed in parallel and are connected with the capsule shell 1 through rubber bands 9, the clamping blocks 8 are triangular, the capsule shell 1 is arc-shaped, the one-way valves 2 are at least one in wide-mouth production, and the one-way valves 2 can be positive pressure and negative pressure valves, so that the use in different environments is facilitated, and the excretion of medicines and the absorption of flora are facilitated;
the two components control the pressure change through physical and chemical reactions; the inner wall of the capsule shell 1 is provided with a capsule wall 3, the capsule wall 3 is doped with a water absorbing material, the water absorbing material is made of cellulose and other materials which are not digested and can absorb water through capillary phenomenon, the size and thickness of the capsule wall determine the water absorbing speed, water enters the capsule, preferably, the capsule is filled with carbon dioxide or ammonia gas, alkali substances or acidic substances are sealed on the inner wall of the capsule shell 1 by glue, when water is met, gas is rapidly reacted and consumed, the pressure of the gas in the capsule shell is reduced, when the pressure reaches a certain degree, the one-way valve 2 is opened, the content in the intestinal tract can be absorbed, the inner wall of the capsule shell 1 below the one-way valve 2 is connected with an absorbing fiber 4, the capsule shell 1 is internally filled with carbon dioxide 5, the bottom end of the capsule shell 1 is provided with a plurality of elastic balls 6, the elastic balls 6 are non-uniform, and the elastic balls 6 are provided with two, so that normal bouncing is facilitated.
Example 5: as shown in fig. 2 and 4, the invention provides a technical scheme, which is applicable to biological reaction control state capsules of animals and humans, and comprises a capsule shell 1, wherein a plurality of one-way valves 2 are embedded in the surface of the capsule shell 1, four clamping blocks 8 are arranged in the one-way valves 2, wherein two clamping blocks 8 are connected with the capsule shell 1 through spring clamping blocks 7, the two clamping blocks 8 are installed in parallel and are connected with the capsule shell 1 through rubber bands 9, the clamping blocks 8 are triangular, the capsule shell 1 is arc-shaped, the one-way valves 2 are at least one in wide-mouth production, and the one-way valves 2 can be positive pressure and negative pressure valves, so that the use in different environments is facilitated, and the excretion of medicines and the absorption of flora are facilitated;
the clamping block 8 can be composed of a special capsule wall 3 or a permeable gel, cellulose doped in the special capsule wall 3 is pressed into the special capsule wall, water absorbing substances, preferably cellulose, protein and starch, are filled in the clamping block 8, the size and thickness of the special capsule wall or the permeable gel determine the water absorbing speed, the water absorbing speed determines the expansion speed, the spring clamping piece 7 or the rubber band 9 is expanded to one side, the one-way valve 2 is opened, and the content in the intestinal tract can be absorbed; the valve closes when the capsule wall breaks.
The working principle and the using flow of the invention are as follows: before use, the patient carries out normal physical examination and diet according to doctor's requirement, then take a sample according to patient's needs, swallow the capsule casing 1 in vivo, and capsule casing 1 surface embedding has check valve 2, when check valve 2 received the pressure, open automatically, through getting rid of carbon dioxide 5, the colony that will gather in vivo enters into capsule casing 1 through the check valve 2 that opens because of pressure differential, and capsule casing 1 inner wall is connected with and absorbs fibre 4, be convenient for absorb the colony of gathering, perhaps dissolve through gel 10, the medicine in the discharge capsule casing 1 is gathering, finally through the extrusion of food, break away from the collection area, check valve 2 is closed because pressure differential diminishes this moment, finally through internal discharge, realize normal colony and gather.
And (3) experimental verification:
the purpose is as follows: the auto-sampler is placed in a simulated gastrointestinal device and the time and area data of the valve switch is acquired.
The capsule preparation method comprises the following steps: the volume of the capsule is selected from one of the number 00, 0 and 1 capsules, the capsule shell is made of biocompatible materials such as polylactic acid, polyacrylonitrile, polytetrafluoroethylene and the like, 2 data are selected from 1 mm/2 mm in a key pressure expansion rupture area, the thickness of the capsule shell is 1-8mm, the area of a cellulose fabric is 0.01, 0.05, 0.1 and 0.15 square centimeters, and the inner fiber cloth of the cellulose fabric is wrapped with alkaline substances such as calcium oxide and magnesium oxide powder. The inside is filled with carbon dioxide gas. Gelatin or other glue is used as a sealing block of the spring, and sealing is started after the gelatin or other glue is dissolved.
The method comprises the following specific steps: the autosampler was placed in a simulated gastrointestinal device, which was TIM (TNO Intestinal Model) (TIM is a multi-unit computer controlled in vitro digestion simulation system developed by Minekus and Havenaar, science Ning Genda, holland) for dynamic testing of drugs. The system is divided into two parts, the stomach, small intestine simulator (TIM-1) and the large intestine simulator (TIM-2). The time and area data for valve opening and closing were obtained using TIM-1 for this experiment. The sampler is manufactured according to the method, 4 groups of 5 capsules with the size of 0 are respectively manufactured, the capsule shell is made of polylactic acid biocompatible materials, the key pressure expansion fracture area is 1mm, the pressure expansion fracture area can resist 0.1-0.3 times of atmospheric pressure, the thickness of the capsule shell is 5mm, the areas of cellulose fabrics are 0.01, 0.05, 0.1 and 0.15 square centimeters, and the inner fiber cloth of the cellulose fabrics is wrapped with alkaline substances such as calcium oxide and magnesium oxide powder for 0.1 gram, and after water absorption; the reaction was started, and the block was sealed with gelatin as a spring, and after dissolution, the seal was started.
In the simulator, the time (minutes) for the sealing film to break and the valve opening and closing time (minutes) were observed.
The results are shown in the following table:
| group of | Cellulose area | Time to rupture of sealing film | Spring seal time | Corresponding gastrointestinal tract section |
| 1 | 0.01 | 725±28.3 | 25±8.7 | Ileum or large intestine |
| 2 | 0.05 | 415±16.1 | 29±6.9 | Jejunum or ileum |
| 3 | 0.1 | 255±9.8 | 21±4.7 | Stomach or duodenum and jejunum |
| 4 | 0.15 | 125±8.6 | 34±9.2 | Stomach |
Through the above experiments, it was demonstrated that samples can be taken over a plurality of time periods, a plurality of sections of the alimentary tract, each sampling time ranging from 20 to 30 minutes, whereas it was observed that each capsule had been filled with the sampled contents within 10 minutes; the device substantially meets the requirements for gastrointestinal sampling.
Finally, it should be noted that: the foregoing is merely a preferred example of the present invention, and the present invention is not limited thereto, but it is to be understood that modifications and equivalents of some of the technical features described in the foregoing embodiments may be made by those skilled in the art, although the present invention has been described in detail with reference to the foregoing embodiments. Any modification, equivalent replacement, improvement, etc. made within the spirit and principle of the present invention should be included in the protection scope of the present invention.
Claims (6)
1. A biological response control status capsule suitable for animals and humans, characterized by: the capsule comprises a capsule shell (1), wherein a plurality of one-way valves (2) are embedded in the surface of the capsule shell (1), the valve switches are controlled by pressure, 2 or more components are placed in the capsule shell or on the inner wall of the capsule shell, the 2 or more components are packed into a plurality of microcapsules, and after gastrointestinal movement extrusion, the packing breaks to react to cause pressure change; the wall thickness of each microcapsule is different, or the composition and the structure are different, and under the extrusion of gastrointestinal movement, the rupture speed is different, so that the reaction speed is controlled;
the one-way valve (2) comprises two spring clamping pieces (7), and the two spring clamping pieces (7) are in contact sealing through a clamping block (8);
the clamping block (8) is triangular, the capsule shell (1) is arc-shaped, and the clamping block (8) is connected with the capsule shell (1) through the spring clamping piece (7);
the clamping block (8) is made of a part of special capsule wall (3) or water permeable gel wrapped water absorbing material, the special capsule wall (3) is made of polymer material doped water absorbing substances, the size and thickness of the special capsule wall (3) or the water permeable gel determine the water absorbing speed, the water absorbing speed determines the expansion speed, the clamping block (8) expands to one side to pull the spring clamping block (7), the one-way valve (2) is opened, and the content in the intestinal tract can be absorbed; and when the clamping block (8) is broken, the valve is closed.
2. The capsule according to claim 1, wherein the partial area of the capsule shell (1) is provided with a special capsule wall (3), the water absorption speed of the special capsule wall (3) doped with water-absorbing substances determines the speed of water entering the capsule shell and determines the reaction time and speed of water as a reactant.
3. A biological response controlling condition capsule for animals and humans according to claim 1, wherein the one-way valve (2) is at least one, and the one-way valve (2) is a positive and negative pressure valve.
4. A biological response controlling capsule for animals and humans according to claim 2, wherein 1 water-swelling substance or growth-swelling substance, or 2 or more substances which react upon water, the reaction leading to pressure change, is placed inside or on the inner wall of the capsule housing (1).
5. A biological response control status capsule for animals and humans according to claim 1, wherein the outer wall of the capsule housing (1) is partially surrounded by a gel (10), the penetration rate of the gel (10) determining the reaction rate, the gel (10) containing enzyme molecules.
6. A biological response control status capsule suitable for animals and humans according to claim 1, characterized in that the speed of response is controlled by controlling the speed of the intestinal content entering the capsule by controlling the permeability of the capsule shell (1) of different thickness.
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| CN202010166965.3A CN111358502B (en) | 2020-03-11 | 2020-03-11 | Biological reaction control state capsule suitable for animals and humans |
| PCT/CN2021/080033 WO2021180133A1 (en) | 2020-03-11 | 2021-03-10 | Biological response control state capsule, sampling and cryopreservation device and method for intestinal contents, and preservation structure and method for sampled material in gastrointestinal tract |
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| CN202010166965.3A CN111358502B (en) | 2020-03-11 | 2020-03-11 | Biological reaction control state capsule suitable for animals and humans |
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| WO2021180133A1 (en) * | 2020-03-11 | 2021-09-16 | 郑州味千生物技术有限公司 | Biological response control state capsule, sampling and cryopreservation device and method for intestinal contents, and preservation structure and method for sampled material in gastrointestinal tract |
| CN112190290A (en) * | 2020-11-08 | 2021-01-08 | 温州芳植生物科技有限公司 | Membrane structure sampling device |
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| JPS6185959A (en) * | 1984-09-22 | 1986-05-01 | バルター ホルツアー | Drug administration method and apparatus |
| WO1990000376A1 (en) * | 1988-07-05 | 1990-01-25 | Cantenys Jose | Intragastric balloon |
| TW201613565A (en) * | 2014-10-15 | 2016-04-16 | Bio Peptide Enhancer Tech Co Ltd | Controlled release sealing capsule in stomach, duodenum, jejunum, ileum and colon |
| EP3240591A4 (en) * | 2014-12-30 | 2018-09-05 | MiniPumps, LLC | Implantable electrolytic diaphragm pumps |
| KR20190091325A (en) * | 2016-12-07 | 2019-08-05 | 프로제너티, 인크. | Gastrointestinal tract detection methods, devices and systems |
| CN110650688B (en) * | 2017-05-19 | 2023-12-22 | 恩维沃生物股份有限公司 | Device and method for collecting gastrointestinal tract samples |
| CN110301943A (en) * | 2019-07-26 | 2019-10-08 | 温州芳植生物科技有限公司 | A kind of gastrointestinal tract sampling medicine releasing capsule |
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