CN108686292A - A kind of medicine releasing capsule - Google Patents
A kind of medicine releasing capsule Download PDFInfo
- Publication number
- CN108686292A CN108686292A CN201810523805.2A CN201810523805A CN108686292A CN 108686292 A CN108686292 A CN 108686292A CN 201810523805 A CN201810523805 A CN 201810523805A CN 108686292 A CN108686292 A CN 108686292A
- Authority
- CN
- China
- Prior art keywords
- drug
- medicine
- powder
- incendivity
- bin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M31/00—Devices for introducing or retaining media, e.g. remedies, in cavities of the body
- A61M31/002—Devices for releasing a drug at a continuous and controlled rate for a prolonged period of time
Abstract
The present invention provides a kind of medicine releasing capsules, and h substance, such as caprophyl, medicine, marker, food are remotely controlled in enteron aisle.The medicine releasing capsule of the present invention includes control cabinet, drug release cabin one and drug release cabin two, and control cabinet includes wireless receiving module, minicell and two microprocessors.After medicine releasing capsule reaches gastrointestinal tract, when control cabinet receives external trigger signal for the first time, drug release cabin one discharges drug;When control cabinet receives external trigger signal for the second time, drug release cabin two discharges drug.Medicine releasing capsule provided by the present invention can discharge drug twice, noninvasive painless, easy to operate.
Description
Technical field
The present invention relates to medical apparatus, specifically a kind of medicine releasing capsule is remotely controlled the capsule releaser eaten in vivo in vitro
Matter, such as caprophyl, medicine, marker, food.
Background technology
Existing drug release remote controlled capsule is chiefly used in human body medicine Absorption Study and new drug development, and drug release remote controlled capsule can be in body
It under the triggering released order outside, directly releases medicine at sufferer, whole process is completely noninvasive, on the one hand can mitigate tradition and insert
The wound and pain that pipe or filling type therapeutic process are brought to patient, on the other hand can obtain higher drug concentration at sufferer
And utilization ratio of drug, there is important application value in terms of clinical treatment.However, clinically haveing not been used to the electronics for the treatment of
Capsule, and drug release remote controlled can only discharge a drug.
Caprophyl transplants (FMT), and the also referred to as micro- raw bacterium transplanting of caprophyl treatment or intestines, is by the function bacterium in healthy human faecal mass
Group, is transplanted in patient's gastrointestinal tract, rebuilds the intestinal flora with normal function, realizes the diagnosis and treatment of enteron aisle and parenterally disease.
Currently, caprophyl transplanting has been considered as a kind of special organ transplant, for treating clostridium difficile infection, inflammatory bowel
Disease, irritable bowel syndrome, metabolic syndrome, neurodevelopment are bad to be eaten with neurodegenerative disease, auto immune enteropathy, enteron aisle
Object allergy etc..Modern caprophyl implantation technique is mainly the method, such as gastroscope, stomach tube, colonoscopy, jejunum pipe etc. of instrument intervention, abdomen
It rushes down the treatments such as type IBS, ulcerative colitis and needs repeatedly transplanting, and faecal microbiota is required for through conduit by stomach, ten every time
Two duodenum 12 inject distal duodenum, and process is complicated, and patient has certain pain, using being restricted.
Invention content
For overcome the deficiencies in the prior art, the present invention provides a kind of medicine releasing capsule, remote control in vitro is eaten to internal
Capsule release caprophyl or other substances, such as medicine, marker, food.The medicine releasing capsule of the present invention can discharge
Drug twice treats two focal zones, noninvasive painless, easy to operate.
Technical scheme of the present invention:
Medicine releasing capsule, including control cabinet, drug release cabin one and drug release cabin two;Control cabinet includes wireless receiving module, micro electric
Pond, microcontroller one, microcontroller two;Drug release cabin one includes micro-thruster one, piston one, medicine holding bin one, sealing-plug one;Drug release
The structure in cabin two and drug release cabin one are completely the same, including micro-thruster two, piston two, medicine holding bin two, sealing-plug two.It is described micro- to push away
Include pedestal one and combustion bin one into device one, has firing circuit on pedestal one and be loaded with micro incendivity powder one, incendivity
Powder one is solidificated on pedestal one;The material of piston one is silica gel, and inside is used as skeleton embedded with iron plate core one;The medicine holding bin one
In contain drug one, drug one is caprophyl freeze-dried powder or caprophyl liquid or marker or food or other treatment drug;Medicine holding bin
Drug two is contained in two, the specific substance and dosage of drug two identical as drug one can also be different;The sealing-plug one
One end with sealing-plug two is hat shape, prevents it from entering capsule, and be easily assembled.
There are solid propellant and detonating agent in the incendivity powder one;The ingredient of solid propellant is 74.6% nitric acid
Potassium, 11.9% sulphur, 13.5% charcoal;The ingredient of detonating agent is dinitrodiazophenol;Incendivity powder two and incendivity powder one
Ingredient it is identical.
One inner wall of the combustion bin is in divergent shape, and dispersion angle is between 10~20 °, the structure and combustion bin of combustion bin two
One is identical.
The course of work of the present invention:
It is micro- when control cabinet receives external trigger signal for the first time after the medicine releasing capsule enters gastrointestinal tract by oral administration
The firing circuit that controller one controls on pedestal one lights incendivity powder one, and the air pressure moment enhancing in combustion bin one pushes
Piston one squeezes medicine holding bin one, and then sealing-plug one is made to fall off, and capsule is discharged in drug one;When control cabinet receives in vitro for the second time
Trigger signal when, microcontroller two control pedestal two on firing circuit light incendivity powder two, the gas in combustion bin two
Moment enhancing is pressed, pushes piston two to squeeze medicine holding bin two, and then sealing-plug two is made to fall off, capsule is discharged in drug two.
Description of the drawings:
Fig. 1 is the structural schematic diagram of medicine releasing capsule of the present invention;
Fig. 2 is the procedure chart of medicine releasing capsule of the present invention drug release.
In Fig. 1 to Fig. 2:
1 - shells, 2 - drug releases cabin one, 3 - control cabinets, 4 - drug releases cabin two, 5 - wireless receiving modules, 6 - microcontrollers
One, 7 - microcontrollers two, 8 - sealing-plugs one, 9 - medicine holding bins one, 10 - drugs one, 11 - pistons one, 12 - iron plates cores one,
13 - micro-thrusters one, 14 - pedestals one, 15 - combustion bins one, 16 - incendivities powder one, 17 - sealing-plugs two, 18 - drug storages
Storehouse two, 19 - drugs two, 20 - pistons two, 21 - iron plates cores two, 22 - micro-thrusters two, 23 - pedestals two, 24 - combustion bins
Two, 25 - incendivities powder two, 26 - minicells.
Specific implementation mode
Embodiment:
As depicted in figs. 1 and 2, a kind of medicine releasing capsule, including control cabinet 3, drug release cabin 1, drug release cabin 24;Control cabinet 3 wraps
Include wireless receiving module 5, minicell 26, microcontroller 1, microcontroller 27;Release the drug cabin 1 include micro-thruster 1,
Piston 1, medicine holding bin 1, sealing-plug 1;The structure in drug release cabin 24 and drug release cabin 1 are completely the same, including micro-thruster
2 22, piston 2 20, medicine holding bin 2 18, sealing-plug 2 17.
Micro-thruster 1 includes pedestal 1 and combustion bin 1, has firing circuit on pedestal 1 and is loaded with micro
Incendivity powder 1, incendivity powder 1 are solidificated on pedestal 1;The material of piston 1 is silica gel, and inside is embedded with iron
Label 1 is used as skeleton, prevents piston 11 from bending, reaches better seal effect;In medicine holding bin 1 and medicine holding bin 2 18
Containing the caprophyl freeze-dried powder of equivalent, one end of sealing-plug 1 and sealing-plug 2 17 is hat shape, prevents it from entering capsule, and
Convenient for assembling.
There are solid propellant and detonating agent in incendivity powder 1;The ingredient of solid propellant be 74.6% potassium nitrate,
11.9% sulphur, 13.5% charcoal;The ingredient of detonating agent is dinitrodiazophenol;Incendivity powder 2 25 and incendivity powder 1
Ingredient it is identical.
15 inner wall of combustion bin is in divergent shape, and dispersion angle is 12 °, and the structure of combustion bin 2 24 is identical as combustion bin 1.
The course of work of the present embodiment is as follows:Medicine releasing capsule enters after gastrointestinal tract, when control cabinet 3 receives in vitro for the first time
Trigger signal when, microcontroller 1 control pedestal 1 on firing circuit light incendivity powder 1, combustion bin 1
Interior air pressure moment enhancing, pushes piston 1 to squeeze medicine holding bin 1, and then sealing-plug 1 is made to fall off, glue is discharged in drug 1
Capsule;When control cabinet 3 receives external trigger signal second, microcontroller 27 controls the firing circuit on pedestal 2 23
Incendivity powder 2 25 is lighted, the air pressure moment enhancing in combustion bin 2 24 pushes piston 2 20 to squeeze medicine holding bin 2 18, in turn
Sealing-plug 2 17 is set to fall off, capsule is discharged in drug 2 19.
The present invention is not limited to above-mentioned specific implementation mode, according to the above, according to the ordinary technical knowledge of this field
And customary means, under the premise of not departing from above-mentioned basic fundamental thought of the invention, the present invention can also make other diversified forms
Equivalent modifications, replacement or change, all fall among protection scope of the present invention.
Claims (5)
1. a kind of medicine releasing capsule, which is characterized in that the capsule includes control cabinet (3), drug release cabin one (2), drug release cabin two (4);
Control cabinet (3) includes wireless receiving module (5), minicell (26), microcontroller one (6), microcontroller two (7);Release the drug cabin
One (2) include micro-thruster one (13), piston one (11), medicine holding bin one (9), sealing-plug one (8);The structure of drug release cabin two (4)
It is completely the same with drug release cabin one (2), including micro-thruster two (22), piston two (20), medicine holding bin two (18), sealing-plug two
(17);The micro-thruster one (13) includes pedestal one (14) and combustion bin one (15), has firing circuit on pedestal one (14) simultaneously
It is loaded with micro incendivity powder one (16);The material of the piston one (11) is silica gel, and inside is made embedded with iron plate core one (12)
For skeleton;Drug one (10) is contained in the medicine holding bin one (10), drug one (10) is caprophyl freeze-dried powder or caprophyl liquid or mark
Remember object or food or other treatment drug;Contain drug two (19) in medicine holding bin two (18), the specific substance of drug two (19) and
Dosage can it is identical as drug one (10) can not also be identical;One end of the sealing-plug one (8) and sealing-plug two (17) is cap
Shape prevents it from entering capsule;Medicine releasing capsule enters after gastrointestinal tract, when control cabinet (3) receives external triggering for the first time
When signal, the firing circuit on microcontroller one (6) control pedestal one (14) lights incendivity powder one (16), combustion bin one
(15) the air pressure moment enhancing in, pushes piston one (11) to squeeze medicine holding bin one (9), and then sealing-plug one (8) is made to fall off, drug
Capsule is discharged in one (10);When control cabinet (3) receives external trigger signal for the second time, microcontroller two (7) controls pedestal
Firing circuit on two (23) lights incendivity powder two (25), and the air pressure moment enhancing in combustion bin two (24) pushes piston
Two (20) squeeze medicine holding bin two (18), and then sealing-plug two (17) is made to fall off, and capsule is discharged in drug two (19).
2. medicine releasing capsule according to claim 1, which is characterized in that have solid propellant propulsion in the incendivity powder one (16)
Agent and detonating agent;The ingredient of solid propellant is 74.6% potassium nitrate, 11.9% sulphur, 13.5% charcoal;The ingredient of detonating agent is
Dinitrodiazophenol.
3. medicine releasing capsule according to claim 1, which is characterized in that the incendivity powder two (25) and incendivity powder
The ingredient of one (16) is identical.
4. medicine releasing capsule according to claim 1, which is characterized in that the combustion bin one (15) inner wall is in divergent shape, hair
Angle is dissipated between 10~20 °.
5. medicine releasing capsule according to claim 1, which is characterized in that the structure of the combustion bin two (24) and combustion bin one
(15) identical.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810523805.2A CN108686292A (en) | 2018-05-28 | 2018-05-28 | A kind of medicine releasing capsule |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810523805.2A CN108686292A (en) | 2018-05-28 | 2018-05-28 | A kind of medicine releasing capsule |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN108686292A true CN108686292A (en) | 2018-10-23 |
Family
ID=63846975
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201810523805.2A Pending CN108686292A (en) | 2018-05-28 | 2018-05-28 | A kind of medicine releasing capsule |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN108686292A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2020180746A1 (en) | 2019-03-01 | 2020-09-10 | Rani Therapeutics, Llc | Propulsive drug delivery from a swallowable device into a patient's intestinal tract |
Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4564363A (en) * | 1983-07-13 | 1986-01-14 | Smithkline Beckman Corporation | Delayed action assembly |
| EP0651667A1 (en) * | 1992-07-13 | 1995-05-10 | Elan Medical Technologies Limited | Medication administering device |
| CN100998905A (en) * | 2006-12-26 | 2007-07-18 | 重庆大学 | Medicine reliesing micro electronic capsule |
| CN101286048A (en) * | 2008-04-18 | 2008-10-15 | 重庆大学 | Programmable oral dosing system |
| CN102481437A (en) * | 2009-04-07 | 2012-05-30 | 皇家飞利浦电子股份有限公司 | Modular ingestible drug delivery capsule |
| CN107949391A (en) * | 2015-05-14 | 2018-04-20 | 克雷斯顿沃控股公司 | For faecal microbiota transplanting composition and be used to prepare and using they method and for delivering their device |
-
2018
- 2018-05-28 CN CN201810523805.2A patent/CN108686292A/en active Pending
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4564363A (en) * | 1983-07-13 | 1986-01-14 | Smithkline Beckman Corporation | Delayed action assembly |
| EP0651667A1 (en) * | 1992-07-13 | 1995-05-10 | Elan Medical Technologies Limited | Medication administering device |
| CN100998905A (en) * | 2006-12-26 | 2007-07-18 | 重庆大学 | Medicine reliesing micro electronic capsule |
| CN101286048A (en) * | 2008-04-18 | 2008-10-15 | 重庆大学 | Programmable oral dosing system |
| CN102481437A (en) * | 2009-04-07 | 2012-05-30 | 皇家飞利浦电子股份有限公司 | Modular ingestible drug delivery capsule |
| CN107949391A (en) * | 2015-05-14 | 2018-04-20 | 克雷斯顿沃控股公司 | For faecal microbiota transplanting composition and be used to prepare and using they method and for delivering their device |
Non-Patent Citations (2)
| Title |
|---|
| 张翼，苏铁熊主编: "《内燃机设计》", 31 August 2016, 北京航空航天大学出版社 * |
| 李晓华: "基于pH值检测智能释药电子胶囊的初步研究", 《中国优秀硕士学位论文全文数据库 医药卫生科技辑》 * |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2020180746A1 (en) | 2019-03-01 | 2020-09-10 | Rani Therapeutics, Llc | Propulsive drug delivery from a swallowable device into a patient's intestinal tract |
| CN113692274A (en) * | 2019-03-01 | 2021-11-23 | 拉尼医疗有限公司 | Propellant drug delivery from a swallowable device into the patient's intestinal tract |
| JP2022523533A (en) * | 2019-03-01 | 2022-04-25 | ラニ セラピューティクス， エルエルシー | Propulsive drug delivery from a swallowable device into the patient's intestinal tract |
| EP3930688A4 (en) * | 2019-03-01 | 2022-11-30 | Rani Therapeutics, LLC | Propulsive drug delivery from a swallowable device into a patient's intestinal tract |
| US11833319B2 (en) | 2019-03-01 | 2023-12-05 | Rani Therapeutics, Llc | Propulsive drug delivery from a swallowable device into a patients intestinal tract |
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| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20181023 |
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| WD01 | Invention patent application deemed withdrawn after publication |