CN111344415B - 生物标志物 - Google Patents

生物标志物 Download PDF

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Publication number
CN111344415B
CN111344415B CN201880074086.9A CN201880074086A CN111344415B CN 111344415 B CN111344415 B CN 111344415B CN 201880074086 A CN201880074086 A CN 201880074086A CN 111344415 B CN111344415 B CN 111344415B
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chromosomal
interactions
probe
nucleic acids
als
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Chinese (zh)
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CN111344415A (zh
Inventor
亚历山大·阿库利特切夫
阿鲁尔·塞尔瓦姆·拉玛达斯
伊万·亨特
马修·萨尔特
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Oxford Biodynamics PLC
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Oxford Biodynamics PLC
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6827—Hybridisation assays for detection of mutation or polymorphism
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/106—Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/118—Prognosis of disease development
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/178—Oligonucleotides characterized by their use miRNA, siRNA or ncRNA

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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Pathology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CN201880074086.9A 2017-10-02 2018-10-01 生物标志物 Active CN111344415B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762566756P 2017-10-02 2017-10-02
US62/566,756 2017-10-02
PCT/GB2018/052808 WO2019069067A1 (en) 2017-10-02 2018-10-01 BIOMARKER

Publications (2)

Publication Number Publication Date
CN111344415A CN111344415A (zh) 2020-06-26
CN111344415B true CN111344415B (zh) 2024-04-30

Family

ID=63834322

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201880074086.9A Active CN111344415B (zh) 2017-10-02 2018-10-01 生物标志物

Country Status (11)

Country Link
US (1) US12006547B2 (https=)
EP (1) EP3692168A1 (https=)
JP (2) JP2020537514A (https=)
KR (1) KR102762920B1 (https=)
CN (1) CN111344415B (https=)
AU (1) AU2018344573B2 (https=)
CA (1) CA3076450A1 (https=)
MY (1) MY200184A (https=)
SG (1) SG11202002503TA (https=)
WO (1) WO2019069067A1 (https=)
ZA (1) ZA202001821B (https=)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI884984B (zh) * 2019-09-11 2025-06-01 英商牛津生物力學公眾有限公司 診斷染色體標記
GB202016176D0 (en) * 2020-10-12 2020-11-25 Oxford BioDynamics PLC Disease marker
JP2024504062A (ja) * 2021-01-07 2024-01-30 オックスフォード バイオダイナミックス ピーエルシー 染色体相互作用
CN117203350A (zh) * 2021-01-07 2023-12-08 牛津生物动力公共有限公司 染色体相互作用
CN113035298B (zh) * 2021-04-02 2023-06-20 南京信息工程大学 递归生成大阶数行限制覆盖阵列的药物临床试验设计方法

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009147386A1 (en) * 2008-06-02 2009-12-10 Oxford Biodynamics Limited Methods of detecting long range chromosomal interactions
WO2016207653A1 (en) * 2015-06-24 2016-12-29 Oxford Biodynamics Limited Detection of chromosome interactions
WO2017001568A1 (en) * 2015-07-01 2017-01-05 Universitat De Lleida Treatment and prevention of amyotrophic lateral sclerosis

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2116280A1 (en) * 1993-03-05 1994-09-06 Marcy E. Macdonald Huntingtin dna, protein and uses thereof
AU2006264564B2 (en) * 2005-07-04 2012-04-19 Erasmus University Medical Center Chromosome conformation capture-on-chip (4c) assay
JP5503942B2 (ja) * 2009-10-30 2014-05-28 シスメックス株式会社 疾患の罹患の判定方法
US8663919B2 (en) * 2011-05-18 2014-03-04 Life Technologies Corporation Chromosome conformation analysis
WO2018115802A1 (en) 2016-12-23 2018-06-28 Oxford Biodynamics Limited Typing method

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009147386A1 (en) * 2008-06-02 2009-12-10 Oxford Biodynamics Limited Methods of detecting long range chromosomal interactions
WO2016207653A1 (en) * 2015-06-24 2016-12-29 Oxford Biodynamics Limited Detection of chromosome interactions
WO2017001568A1 (en) * 2015-07-01 2017-01-05 Universitat De Lleida Treatment and prevention of amyotrophic lateral sclerosis

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
C.R. Lim.EPIGENETIC SIGNATURES AND EARLY DETECTION OF NEURODEGENERATIVE DISEASES: DEVELOPMENT OF STRATIFYING BIOMARKERS FOR AMYOTROPHIC LATERAL SCLEROSIS IN ASIAN COHORTS.《WCN2017》.2017,第1页. *
EPIGENETIC SIGNATURES AND EARLY DETECTION OF NEURODEGENERATIVE DISEASES: DEVELOPMENT OF STRATIFYING BIOMARKERS FOR AMYOTROPHIC LATERAL SCLEROSIS IN ASIAN COHORTS;C.R. Lim;《WCN2017》;20170930;第1页 *
JUNCTOPHILIN 3 (JPH3) EXPANSION MUTATIONS CAUSING HUNTINGTON DISEASE LIKE 2 (HDL2) ARE COMMON IN SOUTH AFRICAN PATIENTS WITH AFRICAN ANCESTRY AND A HUNTINGTON DISEASE PHENOTYPE;A Krause;《Am J Med Genet B Neuropsychiatr Genet》;20151001;第168卷(第7期);第573-585页 *

Also Published As

Publication number Publication date
ZA202001821B (en) 2022-10-26
MY200184A (en) 2023-12-12
JP2023182591A (ja) 2023-12-26
AU2018344573A1 (en) 2020-04-09
JP2020537514A (ja) 2020-12-24
CA3076450A1 (en) 2019-04-11
SG11202002503TA (en) 2020-04-29
NZ762713A (en) 2025-03-28
KR102762920B1 (ko) 2025-02-04
WO2019069067A1 (en) 2019-04-11
EP3692168A1 (en) 2020-08-12
KR20200058527A (ko) 2020-05-27
JP7701419B2 (ja) 2025-07-01
US12006547B2 (en) 2024-06-11
AU2018344573B2 (en) 2020-09-17
CN111344415A (zh) 2020-06-26
US20200407790A1 (en) 2020-12-31

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