CN111315417B - Inactivation device and inactivation method for influenza virus - Google Patents
Inactivation device and inactivation method for influenza virus Download PDFInfo
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- CN111315417B CN111315417B CN201980003882.8A CN201980003882A CN111315417B CN 111315417 B CN111315417 B CN 111315417B CN 201980003882 A CN201980003882 A CN 201980003882A CN 111315417 B CN111315417 B CN 111315417B
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L9/00—Disinfection, sterilisation or deodorisation of air
- A61L9/015—Disinfection, sterilisation or deodorisation of air using gaseous or vaporous substances, e.g. ozone
- A61L9/04—Disinfection, sterilisation or deodorisation of air using gaseous or vaporous substances, e.g. ozone using substances evaporated in the air without heating
- A61L9/12—Apparatus, e.g. holders, therefor
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2209/00—Aspects relating to disinfection, sterilisation or deodorisation of air
- A61L2209/10—Apparatus features
- A61L2209/13—Dispensing or storing means for active compounds
- A61L2209/134—Distributing means, e.g. baffles, valves, manifolds, nozzles
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Abstract
The influenza virus can be inactivated even at a relative humidity of 30% to 50% at which the influenza virus is difficult to inactivate by chlorine dioxide gas. A device for inactivating influenza virus, comprising a container and an air circulating means, wherein a reservoir for hypochlorous acid solution and an air circulating means for generating hypochlorous acid gas are formed in a circular cross-sectional shape, and are respectively disposed coaxially with each other, and hypochlorous acid gas is generated by swirling hypochlorous acid solution in a liquid phase state in which liquid droplets and liquid fine particles are not generated by surface friction between the air in the air circulating means and the hypochlorous acid solution, and the hypochlorous acid gas is discharged while suppressing the amount of moisture discharged by introducing air and discharging the air containing hypochlorous acid gas by the difference in air pressure between an air inlet and an air outlet.
Description
Technical Field
The present invention relates to an inactivation device and an inactivation method for inactivating influenza virus by hypochlorous acid gas.
Conventionally, in order to inactivate floating influenza viruses at room temperature, it is important to keep the relative humidity at 50% or more when chlorine dioxide gas is used to inactivate them. The present invention relates to an apparatus and a method for inactivating an influenza virus, which can inactivate an influenza virus by using a hypochlorous acid gas even at a relative humidity of 30% to 50% at which the influenza virus is difficult to inactivate by a chlorine dioxide gas. More particularly, the present invention relates to an apparatus and a method for inactivating an influenza virus, which can suppress an increase in relative humidity even if the inactivation apparatus is continuously operated to continuously generate hypochlorous acid gas.
Specifically, the hypochlorous acid solution is swirled and shaken by surface friction with air which becomes a swirling flow, thereby suppressing concentration unevenness of the hypochlorous acid solution, generating hypochlorous acid gas so that droplets and liquid fine particles of the hypochlorous acid solution do not scatter, enabling continuous operation, suppressing moisture discharge, and diffusing the hypochlorous acid gas.
Background
Conventionally, there have been known a method of inactivating floating viruses by increasing the relative humidity of a target space, and a technique of inactivating floating viruses by diffusing chlorine dioxide gas in a state where the relative humidity of the target space is equal to or higher than a predetermined value. Heretofore, in order to inactivate floating viruses, it has been important to maintain a humidity environment in which the relative humidity is equal to or higher than a predetermined value.
On the other hand, when the relative humidity becomes high, fungi are liable to propagate. When fungi such as aspergillus or cryptococcus are inhaled, there is a problem that elderly people or patients with low immunity are likely to suffer from pneumonia. In addition, in the modern times where the proportion of elderly people is increasing because pneumonia increases with age, it is an important issue to develop a technology that can prevent infectious diseases caused by floating viruses without increasing relative humidity in order to prevent pneumonia from being caused by fungi.
In 1976 after 15 years of non-patent document 1, non-patent document 2, which is related to infectivity of floating viruses, was published by schafer et al. According to this document, it is known that influenza a floating virus is easily inactivated at room temperature of 20 ℃ or higher and at a relative humidity of 45% to 55% so as to lose infectivity, and that if the relative humidity becomes high, the inactivation effect is rather reduced. Due to the high reliability of this experiment, non-patent document 2 is highly evaluated among influenza experts as a document for clarifying the "relationship between influenza and relative humidity". Further, when the relative humidity is excessively increased to, for example, 70 to 80%, not only the inactivation effect is remarkably reduced, but also the growth of fungi widely known in the modern world is promoted, and pneumonia is likely to occur.
Further, studies for inactivating floating viruses have been repeated, and it has been proposed to diffuse chlorine dioxide gas having an extremely low concentration of 1 unit of 10 parts by volume into a room or hypochlorous acid gas having the same concentration into a room. Non-patent document 3 describes a technique relating to a method for inactivating floating viruses by diffusing chlorine dioxide gas. In this case, the gas concentration, the exposure time, and the predetermined humidity environment are important, but particularly, it is important to maintain the relative humidity at 50% or more.
However, in the space sterilizing apparatus described in patent document 1, the contact area between the air and the hypochlorous acid solution is increased, and not only the hypochlorous acid gas but also water diffuses into the air as water vapor. Specifically, the relative humidity in the room is increased to 80%, and therefore, humidification tends to be excessive, and the propagation of fungi tends to be promoted. Therefore, the space sterilization apparatus described in patent document 1 is not suitable for the purpose of inactivating influenza viruses in a sanitary air environment.
Further, in the bacteria removing and deodorizing apparatus described in patent document 2, there is disclosed a technique in which air is directly supplied to the liquid surface of a chemical liquid tank storing hypochlorous acid liquid supplied from a chemical liquid supply tank by a pressurizing means, and the hypochlorous acid gas is diffused by bringing an air flow into contact with the hypochlorous acid liquid which is not moved. However, even when this technique is used, the contact area between the air and the hypochlorous acid solution is increased, and therefore, there is a problem that the humidity tends to become excessively high. Further, it is shown that the effective chlorine concentration of the hypochlorous acid liquid is approximately halved after 7 hours (see fig. 4 of patent document 2), and in order to operate for a long time, it is necessary to supply the hypochlorous acid liquid having a high concentration from the chemical liquid supply tank so as to maintain the concentration of the hypochlorous acid liquid.
Accordingly, the inventors of the present application have made an intensive study to develop an apparatus and a method for inactivating influenza virus without increasing relative humidity at room temperature and easily controlling the concentration of hypochlorous acid solution.
Documents of the prior art
Non-patent document 1: https:// www.ncbi.nlm.nih.gov/PMC/articles/PMC 2134455/Journal of health (The Journal of Hygiene), cambridge University Press (Cambridge University Press), (English), 1961, vol.59, pp.479-86.
Non-patent document 2: virology records (Archives of Virology), (U.S.A.), 1976, vol.51, pp.263-273.
Non-patent document 3: journal of the Japan society of environmental infections, 2017, volume 32, pages 243 to 249.
Patent document
Patent document 1: japanese patent laid-open publication No. 2019-063054
Patent document 2: japanese patent laid-open publication No. 2011-050702
Patent document 3: japanese Kai 2014-170971
Disclosure of Invention
Problems to be solved by the invention
The present invention addresses the problem of providing a device and a method for inactivating influenza viruses using hypochlorous acid gas in a humidity atmosphere gas having a relative humidity of 30% to 50% in which influenza viruses are difficult to inactivate by chlorine dioxide gas, and for easily controlling the concentration of hypochlorous acid solution.
Means for solving the problems
A first aspect of the present invention is an influenza virus inactivation device including a container and an air circulation unit, wherein the container includes a reservoir of hypochlorous acid solution, an air circulation unit, an air inlet port, and an air outlet port, the reservoir and the air circulation unit are formed in a circular cross-sectional shape, the reservoir and the air circulation unit are disposed on the same axis, respectively, and the air circulation unit includes a disk that rotates around the same axis, the hypochlorous acid solution in the reservoir generates hypochlorous acid gas from the hypochlorous acid solution into the air by surface friction between the air and the hypochlorous acid solution with the rotation of the disk, and the hypochlorous acid gas is introduced into the air circulation unit by a liquid phase state in which liquid droplets and liquid particles are not generated, and the air containing the hypochlorous acid gas is discharged from the air circulation unit while suppressing a discharge amount of moisture.
In the influenza virus inactivation device according to the first aspect of the present invention, the reservoir of the hypochlorous acid solution in the container and the air circulation unit for generating hypochlorous acid gas are disposed coaxially, and are connected to each other so that their cross-sectional shapes are circular cross-sectional shapes. When the disk disposed in the air circulation unit is rotated around the shaft, the air in the air circulation unit swirls in the horizontal direction along with the rotation of the disk around the shaft. In this case, the surface of the hypochlorous acid solution is rubbed with only the swirling air, whereby the hypochlorous acid solution is swirled and shaken in a liquid phase state without generating liquid droplets or liquid fine particles.
The term "swing" as used herein means not only a state of swinging around the central axis but also a state of a liquid surface in which one side of the liquid surface is high and the other side thereof with the axis therebetween is inclined relatively low, and further, in the inclined state of the liquid surface, the liquid surface swings while swinging around the axis. Since the hypochlorous acid solution is swirled in the storage section, the concentration of the hypochlorous acid solution is easily uniform, and the hypochlorous acid gas is easily generated in a range up to a predetermined height on the inner surface of the periphery of the container, which is wetted with the hypochlorous acid solution.
Further, air is introduced into the air circulation portion by the air pressure difference between the air inlet port and the air outlet port generated by the rotation of the disc around the shaft, and the air containing the hypochlorous acid gas is discharged from the air circulation portion, so that the discharge amount of the air containing the hypochlorous acid gas becomes extremely slow. Thereby, the hypochlorous acid gas can be discharged in a state of suppressing the water discharge amount, the room temperature space can be filled with more than 0.007ppm of the hypochlorous acid gas, and a humidity environment with a relative humidity of 30% to 50% can be realized.
In addition, since hypochlorous acid gas generated by the evaporation of the hypochlorous acid solution is unstable and the sterilization/disinfection properties are difficult to maintain, it is important to continuously generate hypochlorous acid gas. In addition, conventionally, a significant influenza virus inactivation effect has been obtained in a humidity environment in which the relative humidity, which is not effective for virus inactivation even when only humidification or addition of chlorine dioxide gas, is 30% to 50%. This is shown in the embodiment (see fig. 1) described later.
According to the inactivation device of the first aspect of the present invention, the heretofore-unavailable advantageous effect of inactivating influenza viruses by continuously generating hypochlorous acid gas even in a dry atmosphere gas is achieved. According to the inactivation device of the first invention of the present invention, the amount of humidification per hour is per small16cc or less (see type B in Table 2). On the other hand, at 25m 3 The rated humidification capacity of a universal humidifier suitable for use in a large room is 300cc per hour.
The inactivation device of the first invention of the present invention is extremely small, about 1/20, compared to a general humidifier, and therefore, even a highly enclosed space is not excessively humidified, and thus, a beneficial effect that continuous operation is possible and fungi are not easily produced can be achieved. Further, since the liquid fine particles of the hypochlorous acid solution are not discharged into the indoor space, there is no problem such as corrosion of the surface of the metal material present in the indoor space, poor insulation of the circuit component, discoloration of the colored fiber material, or the like. Further, since the liquid fine particles of the hypochlorous acid solution are not discharged into the indoor space, there is no problem such as corrosion of the surface of the metal material present in the indoor space, poor insulation of the circuit component, discoloration of the colored fiber material, or the like.
A second aspect of the present invention is the influenza virus inactivation device according to the first aspect of the present invention, further comprising a shaft body provided so as to hang down from a central axis of the disk and immersed in the hypochlorous acid solution, wherein a tip of the shaft body is closed, and a vortex is generated around the shaft body in the hypochlorous acid solution in the liquid phase state in accordance with the axial rotation of the shaft body.
In the deactivation device of the second invention, the lower end portion of the shaft body that hangs down from the center of the disk is closed. When the disk revolves, the shaft body immersed in the hypochlorous acid solution rotates around the shaft, but the hypochlorous acid solution is not sucked up from the lower end portion of the shaft body by a difference in gas pressure or the like and is scattered to the disk by closing the lower end portion of the shaft body. Thus, the hypochlorous acid solution swirls in a liquid phase state without generating droplets or liquid particles.
In addition, since the shaft body rotates around the shaft body in a state of being immersed in the hypochlorous acid solution, a vortex is generated around the shaft body in the hypochlorous acid solution in a manner of stirring the hypochlorous acid solution. The vortex flow is repeatedly generated and disappeared in turn at an arbitrary position around the shaft body in the hypochlorous acid solution. Thereby, the hypochlorous acid solution is easily stirred uniformly.
The hypochlorous acid gas present in the space is adsorbed on the inner wall surface of the space or the surface of the object present in the space, and the concentration thereof is lowered, but according to the second invention, it is possible to realize advantageous effects that the hypochlorous acid gas can be supplied stably and continuously without the need to control the concentration of the hypochlorous acid solution (see type a in fig. 7), and the inactivation effect of the influenza virus in the indoor space can be maintained for a long time, which have not been achieved in the past.
A third aspect of the present invention is the inactivation device for influenza virus according to the first or second aspect, wherein the container is a sphere including an upper body and a lower body, the lower body is the storage section, the upper body is the air circulation section and has the air circulation unit, the air inlet port, and the air outlet port, the disk has a protruding piece protruding from a top surface and extending radially, and an air pressure in a disk peripheral portion is higher than an air pressure in a disk central portion by a pivoting movement of the protruding piece along with the pivoting movement of the disk, so that air is introduced from the air inlet port into the disk central portion, and air containing hypochlorous acid gas is discharged from the disk peripheral portion to the air outlet port.
The deactivation device of the third invention is constituted as a sphere including an upper body and a lower body. By forming the container as a sphere, the hypochlorous acid solution can be easily smoothly oscillated along the bottom surface so as to be in a liquid surface state in which one side around the liquid surface is high and the other side across the axis is low and inclined, and further, the liquid surface can be easily oscillated to be rotated around the axis in an inclined liquid surface state.
Further, as the disc is rotated about the shaft, the protruding pieces extending radially on the top surface of the disc are rotated about the shaft, and thus a centrifugal force is likely to act on the air near the protruding pieces, and the air pressure in the peripheral portion of the disc becomes higher than the air pressure in the central portion of the disc. The hypochlorous acid gas is discharged while suppressing the moisture discharge amount by sucking the air easily without using a pressurizing device for directly pressurizing the gas by sucking the outside air from the air inlet port into the central portion of the disk and discharging the inside air from the peripheral portion of the disk to the air outlet port.
According to the third aspect of the present invention, the inner surface of the container can be easily wetted with the hypochlorous acid solution over a large area, hypochlorous acid gas can be easily generated, an additional pressurizing device is not required except for the disk for swirling the hypochlorous acid solution, and the effect that liquid droplets and liquid fine particles are less likely to be generated as compared with the case where air is introduced by using a pressurizing device can be achieved.
A fourth aspect of the present invention is a method for inactivating an influenza virus, wherein a hypochlorous acid solution is swirled with air by rubbing against a surface of the horizontally swirled air in a liquid phase state in which liquid droplets or liquid fine particles are not generated, and hypochlorous acid gas is diffused while suppressing moisture discharge, and a space for inactivating an influenza virus is filled with 0.007ppm or more of hypochlorous acid gas, whereby an influenza virus can be inactivated even in a humidity environment having a relative humidity of 30% or more and 50% or less.
According to the inactivation method of the fourth aspect of the present invention, it is possible to achieve an advantageous effect that influenza viruses can be inactivated by continuously generating hypochlorous acid gas even in a dry atmosphere. Further, in the case where the contact surface area of air and hypochlorous acid solution is limited, the amount of discharged water is suppressed to diffuse hypochlorous acid gas, and therefore, excessive humidification does not occur even in a highly closed space, and therefore, a continuous operation is enabled, and there is an advantageous effect that fungi are not easily generated.
A fifth aspect of the present invention is the method for inactivating an influenza virus according to the fourth aspect, wherein a vortex is generated in the liquid phase inside the hypochlorous acid solution which swirls.
According to the fifth aspect of the present invention, it is possible to realize advantageous effects that hypochlorous acid gas can be stably and constantly supplied without requiring concentration control of a hypochlorous acid solution, and the inactivation effect of influenza virus in an indoor space can be maintained for a long period of time, which have not been achieved in the past.
A sixth aspect of the present invention is the method for inactivating an influenza virus according to the fourth or fifth aspect, wherein air is introduced from a radially inner portion of the swirling flow of the horizontally swirling air by a difference in radially inner and outer air pressures of the swirling flow, and the air is swirled, and air containing hypochlorous acid gas in the air is discharged into the space through a radially outer portion of the swirling flow.
According to the sixth aspect of the present invention, a dedicated pressurizing device for sucking air and discharging air containing hypochlorous acid gas is not required. Compared with the case of blowing air by using a pressurizing device having a fan, the effect of making it difficult to generate liquid droplets and liquid particles can be achieved.
ADVANTAGEOUS EFFECTS OF INVENTION
According to the inactivation device of the first aspect and the inactivation method of the fourth aspect of the present invention, the heretofore-unavailable advantageous effect of inactivating influenza viruses by continuously generating hypochlorous acid gas even in a dry atmosphere gas is achieved. Further, since the hypochlorous acid gas is diffused while the amount of moisture discharged is suppressed, excessive humidification does not occur even in a highly closed space, and thus, a continuous operation is possible and fungi are less likely to occur.
According to the inactivation device of the second aspect and the inactivation method of the fifth aspect of the present invention, it is possible to achieve advantageous effects that hypochlorous acid gas can be supplied stably and continuously without requiring concentration control of hypochlorous acid solution, and that the inactivation effect of influenza viruses in the indoor space can be maintained for a long period of time, which have not been achieved before.
According to the inactivation system of the third aspect of the present invention, the inner surface of the container can be easily wetted with the hypochlorous acid solution over a large area, hypochlorous acid gas can be easily generated, an additional pressurizing means is not required except for the disk for swirling the hypochlorous acid solution, and the effect that liquid droplets and liquid fine particles are less likely to be generated as compared with the case where air is introduced by using a pressurizing means can be achieved.
According to the inactivation method of the sixth aspect, a dedicated pressurizing device for sucking air and discharging air containing hypochlorous acid gas is not required. Compared with the case where air is blown using a pressurizing device having a fan, the effect that liquid droplets and liquid fine particles are less likely to be generated can be achieved.
Drawings
Fig. 1 is a diagram illustrating an inactivated state of influenza virus under a dry ambient gas.
Fig. 2 is a diagram illustrating a state in which humidity changes due to continuous operation.
FIG. 3 is an explanatory view of embodiment 1.
FIG. 4 is an explanatory view of embodiment 2.
FIG. 5 is an explanatory view of embodiment 3.
FIG. 6 is an explanatory view of comparative example 1.
FIG. 7 is an explanatory view of the amount of hypochlorous acid gas generated in each example.
Detailed Description
For the purpose of "inactivating influenza viruses by continuously generating hypochlorous acid gas even in dry ambient gas", the hypochlorous acid gas is diffused while suppressing the moisture discharge amount by causing the hypochlorous acid solution to swirl with the air by surface friction with the horizontally swirling air, thereby restricting the contact area between the air and the hypochlorous acid solution and preventing the generation of liquid droplets and liquid fine particles.
First, a hypochlorous acid solution was used in place of the chlorine dioxide water stored in the chlorine dioxide gas generating apparatus in a stable state, and the gas volume was 10m in the Sendai medical center of the national hospital organization 3 In the laboratory, hypochlorous acid gas was diffused from a hypochlorous acid solution having a pH of 4.14 and a concentration of 97ppm by using an O-type apparatus shown below, and the inactivation effect of influenza virus was examined.
Hypochlorous acid gas was diffused into the test chamber for 1 hour in advance to make the gas concentration 0.007ppm, and a test solution for influenza virus was injected to continuously operate the inactivation unit, thereby verifying the reduction rate of infectious Titer (infectious Titer) of the floating amount of influenza virus after 1 hour. As a result, as shown in fig. 1, after 60 minutes, in a temperature environment of 20 ℃, in the case where the relative humidity is 30% to 35%, the infectious titer decreased by 1 (see fig. 1 a) by about 1700 minutes, and in the case where the relative humidity is 50% to 51%, the infectious titer decreased by 1 (see fig. 1B) by about 9000 minutes can be confirmed. The gas concentration after the completion of the 1-hour experiment was 0.012ppm.
In addition, at 30m 3 In the air-conditioned living room of (2), the O-ring device of example 1 described later is continuously operated for about 10 hours in a state where the door having the ventilation louver is closed. As shown in fig. 2, the temperature and humidity were maintained at about 23 ℃, and it was confirmed that the humidification by the O-type device could not be recognized even when only the air in the corridor was introduced from the ventilation louver with respect to the humidity, and that there was no possibility that the humidity was too high in a living room for general use.
Hereinafter, the measurement results of the generation amount and generation time of hypochlorous acid gas (hereinafter, referred to as gas) generated while swirling and shaking hypochlorous acid solution in examples, 2 examples and 1 comparative example, which are the starting points of the present invention, and the moisture emission amount generated as a result thereof will be shown, and the inactivation effect of influenza virus will be described. For easy understanding, the embodiments and functions of example 1, example 2, example 3, and comparative example 1 are specifically described, and the effects thereof are compared and described.
[ example 1 ]
An apparatus 1 for inactivating an influenza virus (hereinafter referred to as an O-type apparatus) will be described as an apparatus of example 1 with reference to fig. 3. The overall shape of the O-ring is in the shape of a sphere with a diameter of 17cm, and the O-ring comprises an upper body 10 and a lower body 20 which can be separated. The upper body serves as an air circulation unit, and includes a motor 11 as a drive unit to which electric power is supplied from a power supply not shown. A disk 12 of 9cm in diameter that rotates around the drive shaft of the motor is attached to the lower portion of the motor, and the lower portion of the disk serves as an air circulation portion 13. Projecting pieces 14 extending in a radial direction are attached to the top surface of the disk. The number of revolutions of the disc 12 is 300 revolutions for 1 minute. The lower body 20 serves as a reservoir for the hypochlorous acid solution. As the hypochlorous acid solution, a hypochlorous acid solution having a concentration of 97ppm and a pH of 4.14, which was prepared by dissolving granules (TMT system, manufactured by JIAHUITER-White Sand) in distilled water, was used.
When the disk 12 rotates around the shaft, the air in the air circulation unit 13 in contact with the disk whirls (see arrow a). When the air swirls, the hypochlorous acid solution in contact with the air swirls due to the surface friction with the air. In the case of the inactivation unit 1, when the disk is rotated around the axis for about 10 seconds as the hypochlorous acid solution swirls, the disk becomes a liquid surface state in which one side around the liquid surface is higher and the other side with the axis therebetween is inclined lower. Then, in the inclined liquid surface state, the liquid surface swings around the axis, and the top of the liquid surface swings around the axis between B (top of the dotted line), C (top of the dotted line), and D (top of the solid line) (see fig. 3).
A shaft body 15 having an inverted conical shape with a lower end open is attached below the axis of the disk. When the shaft body 15 is rotated around the shaft in association with the rotation of the disk 12 around the shaft, the hypochlorous acid solution connected to the inside of the lower end portion rises along the inclined surface of the inner surface of the shaft body, and the hypochlorous acid solution is radially dispersed from the dispersion holes 16 provided at the connection portion between the disk and the shaft body. The dispersed hypochlorous acid solution collided with the inner surface of the container and mostly dropped along the inner surface of the container, but part of the droplets splashed around the disk, and the droplets collided with the wall of the container became fine, and it was also measured that fine droplets were scattered above the disk, and part of the liquid particles were also generated from the air outlet (see Type O in table 1).
An air inlet port 17 and an air diffusion port 18 are formed in the upper body 10. The air pressure at the peripheral portion of the disk is made higher than the air pressure at the central portion of the disk by the rotation of the projected pieces 14 on the top surface of the disk. In an O-ring arrangement, the path from the air inlet port is separate from the path to the air diffusion port with respect to the air circulation 13. A path from the air inlet port 17 to the disk center portion is referred to as an air introduction path (see white arrows in fig. 3), and a path from the disk peripheral portion of the air circulation portion to the air outlet port 18 is referred to as an air discharge path (see black arrows in fig. 3). The air introduced from the outside of the container contains gas and diffuses to the outside of the container only by the pivoting of the disc 12, and thus there is no special pressurizing means. Since air is not blown to the liquid surface of the hypochlorous acid solution by a dedicated pressurizing device, it is difficult to generate liquid droplets and liquid fine particles.
[ example 2 ] A method for producing a polycarbonate
Referring to fig. 4, an influenza virus inactivation apparatus 2 (hereinafter referred to as "type a apparatus") of example 2 will be described. The same structure as that of the deactivation device 1 is denoted by the same reference numerals in the drawings, and description thereof is omitted. The type a device is similar to the type O device except that the shaft body provided below the axis of the disk of the type O device does not have an open lower end portion, but of course, the shaft body may not have an inverted conical shape and the connection portion between the disk and the shaft body may not have a scattering hole.
Although only one form (D) of the top of the liquid surface is shown in fig. 4, the whirling motion of the top is the same as that of the O-type device. In the a-type apparatus, the speed of the whirling of the hypochlorous acid solution portion in contact with the periphery of the shaft body is higher than the speed of the whirling and shaking of the hypochlorous acid solution as a whole due to the surface friction with the air. Therefore, the hypochlorous acid solution is displaced at any position along with the swirling motion of the hypochlorous acid solution, and the vortex 19 is generated and eliminated, so that the hypochlorous acid solution is easily stirred uniformly, and the concentration of the whole is easily made uniform.
[ example 3 ]
An influenza virus inactivation apparatus 3 (hereinafter referred to as "type B apparatus") of example 3 will be described with reference to fig. 5. In the B-type device, the shaft body provided below the axis of the disc of the O-type device is removed. In the type B device, the swirling motion of the hypochlorous acid solution is generated only by surface friction with air.
Therefore, the inclination of the slope of the liquid surface, which is generated by the whirling of the hypochlorous acid solution and is higher on one side of the periphery of the liquid surface and lower on the other side with the axis center therebetween, is smaller than that of the O-type apparatus and the a-type apparatus, and the whirling and shaking speed of the hypochlorous acid solution is slower than that of the O-type apparatus and the a-type apparatus. This has a feature that no liquid droplets or liquid particles are generated in the air circulation portion, and the amount of moisture diffusion to the outside of the container is extremely small.
[ COMPARATIVE EXAMPLE 1 ]
Referring to fig. 6, an influenza virus inactivation apparatus 4 (hereinafter referred to as a type C apparatus) of comparative example 1 will be described. In the C-type device, stirring plate bodies 21 are attached to both sides of the lower end portion of a shaft body provided below the axis of the disk of the a-type device. In the C-type apparatus, in addition to the whirling motion of the hypochlorous acid solution in the a-type apparatus, the hypochlorous acid solution is vigorously stirred by the pivoting motion of the stirring plate body 21. Therefore, in the vicinity of the liquid contact portion of the shaft body, the solution is swirled while the solution is being foamed 22 with air being drawn from the surface of the hypochlorous acid solution into the solution. However, the top surface of the disc was not wetted with the hypochlorous acid solution, and no liquid droplet or liquid particle was observed to diffuse out of the container.
Here, the concentration according to the number of liquid fine particles having different particle diameters which are scattered to the outside of the deactivation apparatus of the O-type apparatus and the a-type apparatus will be described. The concentration of liquid particles is 1.2m 3 The glove box of (1) was equipped with either an O-type device or an A-type device, and operated for 60 minutes, and the concentration of the number of liquid particles contained in 1 liter of gas at a position 30cm from the outlet was measured for each particle diameter by a semiconductor laser particle counter. The 2 types of devices, i.e., the O-type device and the a-type device, were measured 10 times, and the average value thereof was obtained. The results are shown in Table 1.
[ TABLE 1 ]
| 0.3-0.5μm | 0.5-1μm | 1-2μm | 2-5μm | 5μm< | |
| O type | 1730.2 | 506.4 | 36.4 | 5.0 | 0 |
| Type A | 190.6 | 7.1 | 0 | 0 | 0 |
According to Table 1, in the case of the O-type device, the number concentration of liquid fine particles was 1730 with respect to 0.3 to 0.5 μm in diameter where the particle diameter was small. In addition, a small number concentration of liquid particles was observed with respect to a diameter of 1 μm or more, which is liable to be corroded or discolored. This is considered to be caused by the particle size of the hypochlorous acid solution scattered from the disk toward the inner surface of the container becoming fine. On the other hand, generation of liquid fine particles having a large particle diameter exceeding 5 μm was not observed. As shown in fig. 2, even in a general living room, the O-type device cannot generate a liquid particle number concentration of such an amount as to increase the humidity in the living room.
On the other hand, in the case of the a-type device, the generation of liquid fine particles was hardly observed in all particle diameters as compared with the O-type device. In the B-type apparatus and the C-type apparatus, since the particles of the hypochlorous acid solution are not scattered by the disk like the a-type apparatus, it can be estimated that almost no liquid fine particles are generated outside the apparatus like the a-type apparatus in all particle diameters.
Further, with respect to the operation for about 12 hours from the start of the operation, a comparison table of the moisture discharge rate from each deactivation device and the total gas production rate is shown in table 2, and fig. 7 shows the discharge rate from each deactivation device up to each hour in a graphTotal production of gas. Further, since the B-type device and the C-type device hardly observed generation of gas after the lapse of 4 hours, the measurement was terminated at 4 hours. The experiment was at 1.25m 3 In a closed space of 20 ℃ in which no gas flow is generated, and driving each deactivation device.
Specifically, the number of measurements that can draw the gradient of the gas generation rate is measured for every 1 hour of 12 hours so that the gas generation amount per hour can be grasped, and a functional formula of the gas generation rate is calculated. The total gas production is then calculated for each hour as a function of the gas production rate for each hour and summed to determine the total gas production. The moisture discharge rate to the outside of the apparatus was determined by dividing the decrease amount of the hypochlorous acid solution by the measurement time.
[ TABLE 2 ]
First, the hypochlorous acid gas generation rate from the deactivation apparatus shown in each example will be described with reference to fig. 7. In FIG. 7, the dashed line marked with Δ shows the total production of gas for the type B device (the slope of the dashed line is the gas production rate: this is true for the other deactivation devices), the dashed line marked with \9633, the dashed line marked with C shows the total production of gas for the type C device, the straight line marked with O shows the total production of gas for the type A device, and the dashed line marked with X shows the total production of gas for the type O device. In fig. 7, each marked point shows a measurement point.
The magnitude of the gas generation amount in 2 hours in the initial stage of operation is reduced roughly in the order of B-type device (B-type in fig. 7), C-type device (C-type in fig. 7), O-type device (O-type in fig. 7), and a-type device (a-type in fig. 7). However, when the operation time is 2 hours or more, the inclination of the broken line between the C-type device and the B-type device becomes small, the gas generation speed decreases, and the generation of gas is hardly observed for 4 hours or more. The gas generation rate of the a-type device was higher than that of the O-type device for an operation time of 8 hours. When the time is 8 hours or more, the gas generation rate of the A-type apparatus becomes slightly smaller than that of the O-type apparatus.
As shown in table 2 and fig. 7, it can be determined that the O-type device and the a-type device have substantially the same performance in terms of the magnitude of the amount of gas generation, the gas generation rate, and the continuity of the gas generation. However, as shown in table 2, the lower surface of the disk of the O-type device was significantly wetted with the hypochlorous acid solution, and as shown in table 1, it was observed that liquid fine particles having a predetermined particle diameter were diffused to the outside of the device. On the other hand, in the type A apparatus, the type B apparatus, and the type C apparatus, except for the lower portion of the inner surface of the container, the liquid particles wetted with the hypochlorous acid solution were not observed to be generated, and the liquid particles discharged to the outside of the apparatus were hardly observed. This is also confirmed by table 1.
In general, it can be determined that the type a device having the largest gas generation amount and a long gas generation duration has the best inactivation effect on influenza viruses. In addition, even in the case of the O-type device, similarly to the a-type device, if the generation of a small amount of liquid microparticles is allowed, the next inactivation effect of influenza virus can be determined to be exhibited, from the viewpoint that the moisture discharge amount is small, the gas generation amount is maximum after the a-type device, and the gas generation duration is long. In addition, although the gas generation amount rapidly decreases after 4 hours has elapsed in the B-mode device, the initial gas generation rate is high, and it is determined that the B-mode device is suitable for use in, for example, a clinic or the like that performs diagnosis in a short time unit. The C-type apparatus of comparative example 1 had a problem that the gas generation amount sharply decreased and the total gas generation amount decreased after 2 hours had elapsed.
(others)
The acidity of the hypochlorous acid solution to be used in the present invention is preferably, but not limited to, ph3.5 to 4.2, and may be determined depending on the relationship with the solution concentration of the hypochlorous acid solution. For example, when the solution concentration is 100ppm, if the pH is decreased, the amount of hypochlorous acid gas generated becomes large, but the risk of generating chlorine gas increases. On the other hand, if the pH is increased, the risk of generating chlorine gas is eliminated, but the generation of hypochlorous acid gas is reduced. The concentration of the hypochlorous acid solution may be appropriately determined within a range free from malodor.
Examples 1 to 3 describe examples of the small deactivation device, but the size is not limited thereto. The present invention may be applied to a part of an air conditioning unit of a building, as a matter of course, as a deactivation device which defines a liquid contact surface area with air and causes a hypochlorous acid solution to swirl by swirling the air.
Although the spherical deactivation device is shown in the above-described examples, the hypochlorous acid solution may be swirled, and the container may have a cylindrical shape.
Of course, the present invention can be applied to various uses such as clinics, hospitals, and tutoring schools, in addition to homes for the elderly and general homes. For example, in the case of an application having a short operation time such as a tutor school, even if the gas generation time is about 4 hours, the gas generation device can be applied to a deactivation device which is likely to generate gas at the initial stage of operation, and in the case of a single room for elderly people, the gas generation device which is prepared for bedtime and continuously generates gas for a long time can be applied.
Of course, if the size of the space is changed, the number of deactivation devices may be changed accordingly, and the size of the container may be changed.
The embodiments disclosed herein are examples in all respects and should be considered as non-limiting. The technical scope of the present invention is not limited to the above description, and all changes that come within the meaning and range of equivalency of the claims are intended to be embraced therein.
Description of the reference numerals
1.2, 3, 4: a deactivation device,
10: upper body, 20: a lower main body,
11: motor, 12: disc, 13: air circulation unit, 14: a convex sheet,
15: shaft body, 16: scattering holes, 17: air intake port, 18: an air diffusion port,
21: stirring plate body, 22: a state of bubbling.
Claims (6)
1. An inactivation device of influenza virus, which comprises a container and an air circulation unit and is characterized in that,
the container has a storage part for hypochlorous acid solution, an air circulating part, an air inlet and an air outlet,
the cross-sectional shapes of the reservoir portion and the air circulation portion are formed in a circular cross-sectional shape, the reservoir portion and the air circulation portion are respectively arranged on the same axis,
the air circulation unit has a disk that rotates around the same axis around a shaft,
in the reservoir, the hypochlorous acid solution is swirled by the friction between the air and the surface of the hypochlorous acid solution with the rotation of the disk around the axis without generating liquid droplets or liquid fine particles, and hypochlorous acid gas is generated from the hypochlorous acid solution into the air,
the air circulating part is provided with an air inlet and an air outlet, the air inlet and the air outlet are respectively provided with an air circulation part, the air circulation part is provided with an air outlet, the air inlet and the air outlet are respectively provided with an air inlet and an air outlet, the air inlet and the air outlet are respectively provided with an air circulation part, the air circulation part is provided with an air circulation part, air pressure difference between the air inlet and the air outlet caused by the rotation of the disc around the shaft causes air to be introduced into the air circulation part, the air containing the hypochlorous acid gas is discharged from the air circulation part, and the hypochlorous acid gas is discharged to the outside of the container under the state that the moisture discharge amount is inhibited.
2. The inactivation device of an influenza virus according to claim 1,
has a shaft body which is provided so as to hang down from the central axis of the disk and is immersed in the hypochlorous acid solution,
the front end of the shaft body is closed,
as the shaft body rotates around the shaft body, a vortex is generated around the shaft body in the hypochlorous acid solution in the liquid phase state.
3. The inactivation device for influenza virus according to claim 1 or 2,
the container is provided as a sphere comprising an upper body and a lower body,
the lower body is used as the storage section,
the upper body is formed with the air inlet and the air outlet, the upper body has the air circulation unit therein,
the disc has protruding pieces protruding from the top surface and extending in a radial shape,
the protruding piece rotates around the shaft in association with the rotation of the disk around the shaft, so that the air pressure at the disk peripheral portion is higher than the air pressure at the disk central portion, air is introduced from the air inlet port into the disk central portion, and air containing hypochlorous acid gas is discharged from the disk peripheral portion to the air outlet port.
4. A method for inactivating an influenza virus,
by surface friction with the horizontally whirling air, under the condition of liquid phase state without producing liquid drops and liquid particles, the hypochlorous acid solution is whirled and shaken along with the air,
in the liquid phase, the hypochlorous acid gas is diffused while suppressing the moisture discharge amount, and the space for inactivating influenza virus is filled with 0.007ppm or more of hypochlorous acid gas, whereby influenza virus can be inactivated even in a humidity environment having a relative humidity of 30% or more and 50% or less.
5. The method for inactivating influenza virus according to claim 4,
a vortex is generated in the liquid phase inside the hypochlorous acid solution which is whirlingly shaken.
6. The method of inactivating influenza virus according to claim 4 or 5,
the air containing the hypochlorous acid gas in the air is discharged to the space through the radially outer portion of the swirling flow.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/JP2019/036251 WO2021049045A1 (en) | 2019-09-14 | 2019-09-14 | Device for inactivating influenza virus and inactivation method |
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| CN111315417A CN111315417A (en) | 2020-06-19 |
| CN111315417B true CN111315417B (en) | 2022-10-21 |
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| JP (1) | JP6654276B1 (en) |
| CN (1) | CN111315417B (en) |
| WO (1) | WO2021049045A1 (en) |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2010227381A (en) * | 2009-03-27 | 2010-10-14 | Sanyo Electric Co Ltd | Air disinfecting apparatus |
| JP2012172923A (en) * | 2011-02-22 | 2012-09-10 | Sharp Corp | Humidifier using electrolytic water |
| CN104321137A (en) * | 2013-04-17 | 2015-01-28 | 株式会社Ｆｍｉ | Chlorine-dioxide-gas generation device and medical-device sterilization box |
| JP2016077598A (en) * | 2014-10-17 | 2016-05-16 | 日立マクセル株式会社 | Mist generator |
| JP2019056514A (en) * | 2017-09-21 | 2019-04-11 | パナソニックＩｐマネジメント株式会社 | Liquid atomization device and air cleaner or air conditioner using the same |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111902218B (en) * | 2018-03-28 | 2022-04-26 | 松下知识产权经营株式会社 | Liquid micronizing device |
| JP6552138B2 (en) * | 2018-06-19 | 2019-07-31 | マクセルホールディングス株式会社 | Mist generator |
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2019
- 2019-09-14 WO PCT/JP2019/036251 patent/WO2021049045A1/en active Application Filing
- 2019-09-14 JP JP2019571096A patent/JP6654276B1/en active Active
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Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2010227381A (en) * | 2009-03-27 | 2010-10-14 | Sanyo Electric Co Ltd | Air disinfecting apparatus |
| JP2012172923A (en) * | 2011-02-22 | 2012-09-10 | Sharp Corp | Humidifier using electrolytic water |
| CN104321137A (en) * | 2013-04-17 | 2015-01-28 | 株式会社Ｆｍｉ | Chlorine-dioxide-gas generation device and medical-device sterilization box |
| JP2016077598A (en) * | 2014-10-17 | 2016-05-16 | 日立マクセル株式会社 | Mist generator |
| JP2019056514A (en) * | 2017-09-21 | 2019-04-11 | パナソニックＩｐマネジメント株式会社 | Liquid atomization device and air cleaner or air conditioner using the same |
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| Publication number | Publication date |
|---|---|
| WO2021049045A1 (en) | 2021-03-18 |
| CN111315417A (en) | 2020-06-19 |
| JP6654276B1 (en) | 2020-02-26 |
| JPWO2021049045A1 (en) | 2021-09-27 |
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