CN111308058A - Counting hole voltage alarm threshold self-adaption method and device and blood cell analyzer - Google Patents
Counting hole voltage alarm threshold self-adaption method and device and blood cell analyzer Download PDFInfo
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- CN111308058A CN111308058A CN202010178291.9A CN202010178291A CN111308058A CN 111308058 A CN111308058 A CN 111308058A CN 202010178291 A CN202010178291 A CN 202010178291A CN 111308058 A CN111308058 A CN 111308058A
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- voltage
- counting hole
- alarm threshold
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/483—Physical analysis of biological material
- G01N33/487—Physical analysis of biological material of liquid biological material
- G01N33/48707—Physical analysis of biological material of liquid biological material by electrical means
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/483—Physical analysis of biological material
- G01N33/487—Physical analysis of biological material of liquid biological material
- G01N33/49—Blood
Abstract
The invention provides a counting hole voltage alarm threshold self-adaptive method, which comprises the following steps: detecting the voltage of the counting hole for multiple times in the initialization process; judging whether the voltage of each counting hole obtained by detection is within a preset value range; if the counting hole voltage obtained by detection is not within the preset value range, deleting the counting hole voltage to obtain all counting hole voltages within the preset value range; and taking all counting hole voltages within a preset value range as raw data and calculating a voltage alarm threshold according to the raw data. The invention can automatically match the counting hole voltage alarm threshold value along with the change of internal and external factors, and improves the accuracy of the test report of the blood cell analyzer.
Description
Technical Field
The invention relates to in-vitro diagnostic equipment, in particular to a counting hole voltage alarm threshold self-adaptive method and device and a blood cell analyzer.
Background
Note that the contents described in this section do not represent all the related art.
The blood cell analyzer can be used for blood cell counting, leukocyte classification and hemoglobin concentration measurement in clinical examination. The counting channel of the blood cell analyzer comprises a front pool and a rear pool, a counting hole for passing cells is arranged between the front pool and the rear pool, conductive liquid is filled in the front pool and the rear pool, the diluted cells are placed in the front pool and then enter the rear pool through the counting hole, and the number of the cells is counted in the passing process.
The blood cell analyzer judges whether the counting hole is normal according to the voltage of the counting hole, if the voltage of the counting hole is lower than the lower limit of an alarm threshold value, the counting channel has 'bubble' faults, and if the voltage of the counting hole is higher than the upper limit of the alarm threshold value, the counting channel has 'hole blockage' faults.
Because there are differences between the hematology analyzers of the same type, and the difference of service environment, the difference of using reagent etc. all can lead to theoretical threshold value can be inequality between the hematology analyzers, if every hematology analyzer all adopts the warning threshold value of factory setting or the warning threshold value through staff reset to judge whether normal through the count hole at every turn, can lead to the count inaccurate, reduce hematology analyzer's work efficiency moreover. In addition, if the relevant factors have changed and the alarm threshold value is not adjusted in time, there is a problem that no alarm is given when the alarm is given or a false alarm is given when the alarm is not given, so that the analyzer cannot obtain a correct blood cell count analysis report. The manual setting of the alarm threshold has strong professional performance, and the operation can be completed under the guidance of professionals, so that the later maintenance of equipment is difficult, and the cost is also high.
Disclosure of Invention
In view of this, in order to solve one of the technical problems in the related art to a certain extent, it is necessary to provide a counting well voltage alarm threshold adaptive method, which can automatically match the counting well voltage alarm threshold along with the change of the internal and external factors, and improve the accuracy of the test report of the blood cell analyzer.
The invention provides a counting hole voltage alarm threshold self-adaptive method in a first aspect, which comprises the following steps:
detecting the voltage of the counting hole for multiple times in the initialization process;
judging whether the voltage of each counting hole obtained by detection is within a preset value range;
if the counting hole voltage obtained by detection is not within the preset value range, deleting the counting hole voltage to obtain all counting hole voltages within the preset value range;
and taking all counting hole voltages within a preset value range as raw data and calculating a voltage alarm threshold according to the raw data.
Further, the calculating a voltage alarm threshold according to the raw data includes:
judging whether the voltage of each counting hole in the preset value range belongs to controllable voltage or not;
if the voltage belongs to the controllable voltage, the voltage alarm threshold value is calculated by using the voltage as useful raw data.
Further, the judging whether each counting hole voltage in the predetermined value range belongs to a controllable voltage includes:
judging whether the counting hole voltage in each preset value range belongs to controllable voltage or not through the variation coefficient;
if the coefficient of variation is smaller than the preset value, the counting hole voltage within the preset value range is controllable voltage, otherwise, the counting hole voltage is regarded as invalid.
Further, the predetermined value is a last voltage alarm threshold value.
The invention provides a counting hole voltage alarm threshold value self-adapting device in a second aspect, which comprises:
the detection module detects the voltage of the counting hole for multiple times in the initialization process;
the judging module is used for judging whether the voltage of each counting hole obtained by detection is within a preset value range;
the acquisition module is used for deleting the counting hole voltage when the counting hole voltage obtained by detection is not in the preset value range so as to obtain all counting hole voltages in the preset value range;
and the calculating module is used for taking all counting hole voltages within a preset value range as raw data and calculating to obtain a voltage alarm threshold according to the raw data.
Further, the calculating a voltage alarm threshold according to the raw data includes:
judging whether the voltage of each counting hole in the preset value range belongs to controllable voltage or not;
if the voltage belongs to the controllable voltage, the voltage alarm threshold value is calculated by using the voltage as useful raw data.
Further, the judging whether each counting hole voltage in the predetermined value range belongs to a controllable voltage includes:
judging whether the counting hole voltage in each preset value range belongs to controllable voltage or not through the variation coefficient;
if the coefficient of variation is smaller than the preset value, the counting hole voltage within the preset value range is controllable voltage, otherwise, the counting hole voltage is regarded as invalid.
Further, the predetermined value is a last voltage alarm threshold value.
A third aspect of the present invention provides a blood cell analyzer comprising:
a processor; and
a memory device comprising processor executable instructions which when executed by the processor perform the steps of said count well voltage alarm threshold adaptation.
A fourth aspect of the present invention provides a computer readable storage medium having stored thereon a computer program which, when being executed by a processor, carries out the steps of the counting well voltage alarm threshold adaptation method.
According to the scheme, the counting hole voltage is detected for multiple times in the initialization process, the counting hole voltage in the preset value range is selected as the original data, the voltage alarm threshold is calculated according to the original data and serves as the alarm threshold, the alarm threshold is dynamically adjusted, manual intervention is not needed, the analyzer can normally work in the maximum reliable range, the problems of counting hole voltage leakage alarm and false alarm are avoided to the maximum, and the accuracy of the test report of the blood cell analyzer is improved.
Drawings
FIG. 1 is a flow chart of a counting well voltage alarm threshold adaptive method of the present invention.
FIG. 2 is a schematic view of the structure of the blood cell analyzer of the present invention.
Fig. 3 is a schematic structural diagram of the counting hole voltage alarm threshold adaptive device of the invention.
The following detailed description will further illustrate the invention in conjunction with the above-described figures.
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments of the present invention without any inventive step, are within the scope of the present invention. It is to be understood that the drawings are provided solely for the purposes of reference and illustration and are not intended as a definition of the limits of the invention.
The counting hole voltage alarm threshold value self-adaption method provided by the first embodiment of the invention is applied to a blood cell analyzer and can comprise the following steps as shown in fig. 1.
S110: the count well voltage is detected multiple times during initialization.
The blood cell analyzer is started up at every time and carries out an initialization process, and in the initialization process, counting hole voltage can be detected once at certain intervals to obtain voltage data of a plurality of counting holes to be used as collected voltage data.
S120: and judging whether the voltage of each counting hole obtained by detection is within a preset value range, if so, executing step S130, and if not, executing step S140.
In this embodiment, the predetermined value may include an upper limit value and a lower limit value, and this step may determine whether all the detected counting hole voltages are between the lower limit value and the upper limit value. The preset value is the last voltage alarm threshold, so that the preliminary effective counting hole voltage can be reserved according to the latest reasonable voltage alarm threshold, and the voltage alarm threshold obtained by subsequent calculation tends to be a matched value.
S130: the count well voltage is removed.
S140: the count pore voltage is retained to obtain all count pore voltages within a predetermined range of values.
S150: and taking all counting hole voltages within a preset value range as raw data and calculating a voltage alarm threshold according to the raw data.
The step of calculating the voltage alarm threshold according to the raw data may specifically include the following steps:
and judging whether the voltage of each counting hole within the preset value range belongs to controllable voltage, if so, calculating the voltage alarm threshold value by taking the voltage as useful original data, and if not, deleting the voltage alarm threshold value.
The effective data can be calculated to obtain a voltage alarm threshold value through a normalization processing mode, and the voltage alarm threshold value can also be calculated by calculating an arithmetic mean of the original data, or the arithmetic mean of the effective original data which is larger than a preset voltage value can be used as an upper threshold value, and the arithmetic mean of the effective original data which is smaller than the preset voltage value can be used as a lower threshold value.
In this embodiment, each counting hole voltage within a predetermined value range can be determined whether the counting hole voltage belongs to a controllable voltage through a variation coefficient, and if the variation coefficient is smaller than a predetermined value, the counting hole voltage within the predetermined value range is the controllable voltage, otherwise, the counting hole voltage is regarded as invalid. Controllability of the counting well voltage was identified by statistical methods.
Through secondary screening, more effective, more reliable, more stable count hole voltage will be obtained, and the voltage alarm threshold value that final calculation obtained can further guarantee the accuracy.
The counting hole voltage alarm threshold self-adaptive method provided by the invention detects counting hole voltage for multiple times in an initialization process, judges whether each detected counting hole voltage is in a preset value range or not, deletes the counting hole voltage if the detected counting hole voltage is not in the preset value range to obtain all counting hole voltages in the preset value range, uses all counting hole voltages in the preset value range as original data and calculates the voltage alarm threshold according to the original data. The method provided by the invention can avoid the problem that the ideal alarm voltage is different from the actual alarm voltage or the manual regulation is inaccurate due to the change of various factors such as environmental factors, self factors, use time and the like, does not need a large amount of manual intervention operation, basically realizes the complete maintenance-free, obviously reduces the maintenance difficulty and the maintenance cost of the instrument, can automatically set the counting hole voltage alarm threshold matched with the change along with the change of internal and external related factors (circuit hardware of the analyzer, the inner diameter of the counting hole, reagents for the analyzer, the environmental temperature and the like), can normally work in the maximum reliable range, avoids the problems of the voltage leakage alarm and the false alarm of the counting hole to the maximum extent, and further improves the accuracy of the test report of the blood cell analyzer.
Fig. 2 is a block diagram of an embodiment of the blood cell analyzer 100 according to the present invention, wherein the blood cell analyzer 100 may include a processor 10, a storage device 20, a front cell 30, a rear cell 40, a counting well 50, a counting well voltage measuring circuit 60, an alarm device 70, a counting well voltage alarm threshold adaptive device, and the like, and further includes a computer program, such as a start-up program, an adaptive program, and the like, stored in the storage device 20 and executable on the processor 10.
The processor 10 may be a Central Processing Unit (CPU), but may also be other general purpose processors, Digital Signal Processors (DSPs), Application Specific Integrated Circuits (ASICs), Field Programmable Gate Arrays (FPGAs) or other programmable logic devices, discrete gate or transistor logic devices, discrete hardware components, etc. The general purpose processor may be a microprocessor or the processor may be any conventional processor or the like, which is the control center of the blood cell analyzer 100 and connects the various parts of the entire blood cell analyzer 100 using various interfaces and lines.
The memory device 20 may be used to store the computer programs and/or modules, and the processor 10 may implement various functions of the blood cell analyzer by operating or executing the computer programs and/or modules stored in the memory device 20 and invoking data stored in the memory device 20. The storage device 20 may mainly include a storage program area and a storage data area, wherein the storage program area may store an operating system, a program required for at least one function, and the like; the storage data area may store data created according to the use of the mobile phone, and the like. In addition, the storage device 20 may include a high speed random access storage device, and may also include a non-volatile storage device, such as a hard disk, a memory, a plug-in hard disk, a smart memory card, a secure digital card, a flash memory card, at least one piece of magnetic disk storage, a flash memory device, or other non-volatile solid state storage device.
The counting hole voltage measuring circuit 60 is used for detecting counting hole voltage, and the alarm device 70 is used for giving an alarm when the detected counting hole voltage is not in a threshold range.
Fig. 3 is a schematic structural diagram of a counting hole voltage alarm threshold adaptive device 200 provided in the present invention, where the counting hole voltage alarm threshold adaptive device 200 may include a detection module 21, a determination module 22, an acquisition module 23, and a calculation module.
The detection module 21 detects the voltage of the counting hole for multiple times in the initialization process;
the judging module 22 is configured to judge whether the voltage of each detected counting hole is within a predetermined value range;
the obtaining module 23 is configured to delete the count pore voltage when the detected count pore voltage is not within the predetermined value range, so as to obtain all count pore voltages within the predetermined value range;
and the calculating module 24 is configured to use all counting hole voltages within a predetermined value range as raw data and calculate a voltage alarm threshold according to the raw data.
Further, the calculating a voltage alarm threshold according to the raw data includes:
judging whether the voltage of each counting hole in the preset value range belongs to controllable voltage or not;
if the voltage belongs to the controllable voltage, the voltage alarm threshold value is calculated by using the voltage as useful raw data.
Further, the judging whether each counting hole voltage in the predetermined value range belongs to a controllable voltage includes:
judging whether the counting hole voltage in each preset value range belongs to controllable voltage or not through the variation coefficient;
if the coefficient of variation is smaller than the preset value, the counting hole voltage within the preset value range is controllable voltage, otherwise, the counting hole voltage is regarded as invalid.
Further, the predetermined value is a last voltage alarm threshold value.
The embodiment of the invention also provides a computer readable storage medium, wherein a computer program is stored on the computer readable storage medium, and when the computer program is executed by a processor, the steps of the counting hole voltage alarm threshold self-adaption method are realized.
The above description is only for the purpose of illustrating the preferred embodiments of the present invention and is not to be construed as limiting the invention, and any modifications, equivalents and improvements made within the spirit and principle of the present invention are intended to be included within the scope of the present invention.
Claims (10)
1. A counting well voltage alarm threshold adaptation method, comprising the steps of:
detecting the voltage of the counting hole for multiple times in the initialization process;
judging whether the voltage of each counting hole obtained by detection is within a preset value range;
if the counting hole voltage obtained by detection is not within the preset value range, deleting the counting hole voltage to obtain all counting hole voltages within the preset value range;
and taking all counting hole voltages within a preset value range as raw data and calculating a voltage alarm threshold according to the raw data.
2. The count hole voltage alarm threshold adaptation method of claim 1, wherein said calculating a voltage alarm threshold from said raw data comprises:
judging whether the voltage of each counting hole in the preset value range belongs to controllable voltage or not;
if the voltage belongs to the controllable voltage, the voltage alarm threshold value is calculated by using the voltage as useful raw data.
3. The counting hole voltage alarm threshold adaptive method of claim 2, wherein said determining whether each of said counting hole voltages within a predetermined range of values is a controllable voltage comprises:
judging whether the counting hole voltage in each preset value range belongs to controllable voltage or not through the variation coefficient;
if the coefficient of variation is smaller than the preset value, the counting hole voltage within the preset value range is controllable voltage, otherwise, the counting hole voltage is regarded as invalid.
4. The count hole voltage alarm threshold adaptation method of any of claims 1-3, wherein the predetermined value is a last voltage alarm threshold.
5. A counting well voltage alarm threshold adaptive device, said device comprising:
the detection module detects the voltage of the counting hole for multiple times in the initialization process;
the judging module is used for judging whether the voltage of each counting hole obtained by detection is within a preset value range;
the acquisition module is used for deleting the counting hole voltage when the counting hole voltage obtained by detection is not in the preset value range so as to obtain all counting hole voltages in the preset value range;
and the calculating module is used for taking all counting hole voltages within a preset value range as raw data and calculating to obtain a voltage alarm threshold according to the raw data.
6. The count hole voltage alarm threshold adaptation device of claim 5, wherein said calculating a voltage alarm threshold from said raw data comprises:
judging whether the voltage of each counting hole in the preset value range belongs to controllable voltage or not;
if the voltage belongs to the controllable voltage, the voltage alarm threshold value is calculated by using the voltage as useful raw data.
7. The counting hole voltage alarm threshold adaptive device of claim 6, wherein said determining whether each of said counting hole voltages within a predetermined range of values is a controllable voltage comprises:
judging whether the counting hole voltage in each preset value range belongs to controllable voltage or not through the variation coefficient;
if the coefficient of variation is smaller than the preset value, the counting hole voltage within the preset value range is controllable voltage, otherwise, the counting hole voltage is regarded as invalid.
8. The count hole voltage alarm threshold adaptation device of any of claims 5-7, wherein the predetermined value is a last voltage alarm threshold.
9. A blood cell analyzer, comprising:
a processor; and
a memory device including processor executable instructions which when executed by the processor perform the steps of counting well voltage alarm threshold adaptation of any one of claims 1 to 4.
10. A computer-readable storage medium, on which a computer program is stored, which, when being executed by a processor, carries out the steps of the counting well voltage alarm threshold adaptation method according to any one of claims 1-4.
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| CN201368872Y (en) * | 2009-03-11 | 2009-12-23 | 山东兰桥医学科技有限公司 | Control circuit of blood analyzer |
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| CN107872982A (en) * | 2015-03-31 | 2018-04-03 | 昂科赛克医疗公司 | System and method for the improved electroporation based on tissue sensing |
| CN110429608A (en) * | 2019-08-19 | 2019-11-08 | 广东电网有限责任公司 | A kind of network system and its disconnection device and Splitting Control |
| CN110857910A (en) * | 2018-08-24 | 2020-03-03 | 深圳市帝迈生物技术有限公司 | Micropore blockage detection device and method and blood cell analyzer |
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2020
- 2020-03-14 CN CN202010178291.9A patent/CN111308058B/en active Active
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN201368872Y (en) * | 2009-03-11 | 2009-12-23 | 山东兰桥医学科技有限公司 | Control circuit of blood analyzer |
| CN107872982A (en) * | 2015-03-31 | 2018-04-03 | 昂科赛克医疗公司 | System and method for the improved electroporation based on tissue sensing |
| CN106067244A (en) * | 2016-06-29 | 2016-11-02 | 中国科学院上海微系统与信息技术研究所 | A kind of sensor threshold value adaptive regulation method for perimeter detection system and system |
| CN110857910A (en) * | 2018-08-24 | 2020-03-03 | 深圳市帝迈生物技术有限公司 | Micropore blockage detection device and method and blood cell analyzer |
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