CN111280451A - Nano lysozyme multivitamin and preparation method thereof - Google Patents

Nano lysozyme multivitamin and preparation method thereof Download PDF

Info

Publication number
CN111280451A
CN111280451A CN202010099979.8A CN202010099979A CN111280451A CN 111280451 A CN111280451 A CN 111280451A CN 202010099979 A CN202010099979 A CN 202010099979A CN 111280451 A CN111280451 A CN 111280451A
Authority
CN
China
Prior art keywords
parts
powder
vitamin
lysozyme
stirring
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
CN202010099979.8A
Other languages
Chinese (zh)
Inventor
何新桥
杨易
杨良嵘
胡杨波
张磊砢
陈卫
何山
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Changde Jizhi Biotechnology Co Ltd
Original Assignee
Changde Jizhi Biotechnology Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Changde Jizhi Biotechnology Co Ltd filed Critical Changde Jizhi Biotechnology Co Ltd
Priority to CN202010099979.8A priority Critical patent/CN111280451A/en
Publication of CN111280451A publication Critical patent/CN111280451A/en
Withdrawn legal-status Critical Current

Links

Images

Classifications

    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23LFOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/17Amino acids, peptides or proteins
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23LFOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23LFOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/105Plant extracts, their artificial duplicates or their derivatives
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23LFOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/125Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives containing carbohydrate syrups; containing sugars; containing sugar alcohols; containing starch hydrolysates
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23LFOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/135Bacteria or derivatives thereof, e.g. probiotics
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23LFOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/15Vitamins
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23LFOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/16Inorganic salts, minerals or trace elements
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23LFOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/17Amino acids, peptides or proteins
    • A23L33/175Amino acids
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23LFOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/17Amino acids, peptides or proteins
    • A23L33/18Peptides; Protein hydrolysates
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23VINDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00Food compositions, function of food ingredients or processes for food or foodstuffs
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23VINDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2400/00Lactic or propionic acid bacteria
    • A23V2400/11Lactobacillus
    • A23V2400/151Johnsonii
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23VINDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2400/00Lactic or propionic acid bacteria
    • A23V2400/11Lactobacillus
    • A23V2400/169Plantarum
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23VINDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2400/00Lactic or propionic acid bacteria
    • A23V2400/11Lactobacillus
    • A23V2400/181Salivarius

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nutrition Science (AREA)
  • Mycology (AREA)
  • Food Science & Technology (AREA)
  • Polymers & Plastics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Botany (AREA)
  • Inorganic Chemistry (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

The invention relates to a nano lysozyme multi-vitamin and a preparation method thereof, wherein the nano lysozyme multi-vitamin comprises the following components: the milk replacer comprises, by weight, 5-15 parts of protein powder, 2-10 parts of synthetic collagen powder, 1-3 parts of chitosan, 1-5 parts of taurine, 0.1-0.8 part of shark chondroitin, 1.5-3.5 parts of amino acid derivatives, 1-4 parts of compound amino acids, 0.5-3.5 parts of carotene, 0.5-1.5 parts of vitamin B1, 0.5-1.5 parts of vitamin B2, 0.5-1.5 parts of vitamin B5, 0.5-1.5 parts of vitamin C, 2-10 parts of spirulina powder, 2-8 parts of cooked soybean powder, 0.06-0.16 part of mineral calcium, 0.06-0.16 part of phosphorus, 0.06-0.16 part of magnesium, 0.06-0.16 part of potassium, 0.06-0.16 part of sodium, 0.03-0.14 part of sulfur, 0.03-0.14 part of chlorine, 0.02-0.12.12 parts of selenium, 0.02-0.12 parts of lactobacillus powder and 0.02-1.12 parts of small molecular weight of iodine. The nanometer lysozyme multivitamin can enhance the immunity of human bodies, promote the digestive system to culture and generate a large amount of nanometer lysozyme after entering the digestive system of the human bodies, and effectively inhibit the propagation of viruses in healthy cells of the human bodies.

Description

Nano lysozyme multivitamin and preparation method thereof
Technical Field
The invention relates to the technical field of biological medicines, in particular to a nano lysozyme multivitamin and a preparation method thereof.
Background
Both humans and animals have their own immune system, which is an important system for the body to perform immune responses and immune functions, and consists of immune organs, immune cells and immune molecules. The immune system has the functions of identifying and eliminating antigenic foreign matters, coordinating with other systems of the organism and maintaining the stable environment and physiological balance in the organism. The immune system is the most effective weapon for defending pathogen invasion, and can find and remove factors causing internal environment fluctuation such as foreign matters, external pathogenic microorganisms and the like.
Therefore, if a nano lysozyme multi-vitamin can be developed, when the immunity of human body is reduced or viruses invade, the immunity of human body and animals can be enhanced, and various invaded viruses including coronavirus can be resisted and killed by the immune system of the nano lysozyme multi-vitamin, so that the nano lysozyme multi-vitamin can have a profound influence on the living health of human beings.
Disclosure of Invention
The invention provides a nano lysozyme multi-vitamin and a preparation method thereof, solves the technical problem that the prior art is lack of means for preventing and treating coronavirus, and realizes the technical effect of providing the nano lysozyme multi-vitamin, which can enhance the autoimmunity of human bodies or animals and can effectively inhibit the propagation of viruses including coronavirus in healthy cells of human bodies.
The invention provides a nano lysozyme multi-vitamin, which comprises the following components: the milk replacer comprises, by weight, 5-15 parts of protein powder, 2-10 parts of synthetic collagen powder, 1-3 parts of chitosan, 1-5 parts of taurine, 0.1-0.8 part of shark chondroitin, 1.5-3.5 parts of amino acid derivatives, 1-4 parts of compound amino acids, 0.5-3.5 parts of carotene, 0.5-1.5 parts of vitamin B1, 0.5-1.5 parts of vitamin B2, 0.5-1.5 parts of vitamin B5, 0.5-1.5 parts of vitamin C, 2-10 parts of spirulina powder, 2-8 parts of cooked soybean powder, 0.06-0.16 part of mineral calcium, 0.06-0.16 part of phosphorus, 0.06-0.16 part of magnesium, 0.06-0.16 part of potassium, 0.06-0.16 part of sodium, 0.03-0.14 part of sulfur, 0.03-0.14 part of chlorine, 0.02-0.12.12 parts of selenium, 0.02-0.12 parts of lactobacillus powder and 0.02-1.12 parts of small molecular weight of iodine.
Preferably, the small molecular active peptide powder is one or a combination of more of soybean peptide powder, corn peptide powder, walnut peptide powder, pea peptide powder, mung bean peptide powder, wheat peptide powder and rice peptide powder.
Preferably, the lactobacillus is one or more of lactobacillus plantarum, lactobacillus salivarius and lactobacillus johnsonii.
Preferably, the following components are included: 8-14 parts of protein powder, 3-6 parts of synthetic collagen powder, 1.5-2.5 parts of chitosan, 2-4 parts of taurine, 0.2-0.5 part of shark chondroitin, 1.6-2.2 parts of amino acid derivatives, 1.2-3 parts of compound amino acids, 1-2.5 parts of carotene, 0.6-1.3 parts of vitamin B1, 0.6-1.3 parts of vitamin B2, 0.6-1.3 parts of vitamin B5, 0.6-1.3 parts of vitamin C, 3.5-6.5 parts of spirulina powder, 2-5 parts of cooked soybean powder, 0.08-0.12 part of mineral calcium, 0.08-0.12 part of phosphorus, 0.08-0.12 part of magnesium, 0.08-0.12 part of potassium, 0.08-0.12 part of sodium, 0.05-0.13 part of sulfur, 0.05-0.05 part of chlorine, 0.05-0.13 part of magnesium, 0.08-0.12 part of magnesium, 0.03-0.12 part of small molecular selenium, 11-1.11 parts of lactobacillus powder and 11-1.5 parts of small molecular iodine.
Preferably, the following components are included: the feed comprises, by weight, 10 parts of protein powder, 5 parts of synthetic collagen powder, 2 parts of chitosan, 3 parts of taurine, 0.5 part of shark chondroitin, 2 parts of amino acid derivatives, 2 parts of compound amino acids, 2 parts of carotene, 1 part of vitamin B1, 1 part of vitamin B2, 1 part of vitamin B5, 1 part of vitamin C, 5 parts of spirulina powder, 3 parts of cooked soybean powder, 0.1 part of each of mineral calcium, phosphorus, magnesium, potassium, sodium, sulfur, chlorine, selenium, iodine and chromium, 2 parts of small molecular active peptide powder and 1.2 parts of lactobacillus.
Based on the same inventive concept, the application also provides a preparation method of the nano lysozyme multi-vitamin, which comprises the following steps:
mixing and stirring the protein powder, the synthetic collagen powder, the chitosan, the taurine, the shark chondroitin, the amino acid derivatives, the compound amino acid, the carotene, the vitamin B1, the vitamin B2, the vitamin B5, the vitamin C, the spirulina powder, the cooked soybean powder, the mineral calcium, the phosphorus, the magnesium, the potassium, the sodium, the sulfur, the chlorine, the selenium, the iodine and the chromium in a set ratio to uniformly form a first mixture;
adding the first mixture into purified water for grinding to obtain a first-grade semi-finished product;
spray drying the primary semi-finished product to obtain a secondary semi-finished product;
and mixing the secondary semi-finished product with the micromolecular active peptide powder and the lactobacillus, and stirring to obtain a finished product of the nano lysozyme multivitamin after the mixture is uniform.
Preferably, the protein powder, the synthetic collagen powder, the chitosan, the taurine, the shark chondroitin, the amino acid derivatives, the compound amino acids, the carotene, the vitamin B1, the vitamin B2, the vitamin B5, the vitamin C, the spirulina powder, the cooked soybean powder, the mineral calcium, the phosphorus, the magnesium, the potassium, the sodium, the sulfur, the chlorine, the selenium, the iodine and the chromium in a set proportion are added into a stirring tank for first stirring, and a first mixture is formed after uniform stirring;
placing the first mixture into a sand mill, adding the first mixture into the purified water, and grinding to obtain a first-grade semi-finished product;
placing the primary semi-finished product in spray drying equipment for spray drying to obtain a secondary semi-finished product;
and adding the secondary semi-finished product, the micromolecule active peptide powder and the lactobacillus into a stirring tank for secondary stirring, and forming a finished product of the nano lysozyme multivitamin after the mixture is uniform.
Preferably, the first stirring time is controlled to be 12-25 minutes;
the grinding time is controlled to be 72-90 minutes;
and the time of the second stirring is controlled to be 30-45 minutes.
Preferably, the time of the first stirring is controlled to be 15 minutes;
the grinding time is controlled to be 84 minutes;
the time of the second stirring was controlled to be 30 minutes.
Preferably, in the first stirring process, the stirring speed is controlled to be 1000 revolutions per minute;
in the second stirring process, the stirring speed is controlled to be 120 revolutions per minute;
the pure water is added in an amount of 500-800 parts by weight.
One or more technical solutions provided in the embodiments of the present application have at least the following technical effects or advantages:
the specific nutrient medium is reasonably proportioned and scientifically processed to research and develop the antiviral nano lysozyme multivitamin which has broad antiviral effect, and on one hand, the antiviral nano lysozyme multivitamin supplements nutrients and mineral substances required by a human body through eating to enhance the immunity of the human body; on the other hand, after the multi-vitamin enters the human digestive system, the digestive system is promoted to culture and generate a large amount of nano lysozyme, the nano lysozyme is easy to combine with the virus due to the sticky sugar characteristic, and then the nano lysozyme replaces human healthy cells to become a new host of the virus, and finally the reproduction of the virus in the human healthy cells is inhibited, and the early clinical experiment verifies that the multi-vitamin inhibitor has a good inhibiting effect on novel coronavirus. In addition, the antiviral food multivitamin is different from chemical or biological medicines, belongs to food medicines, has good safety and does not generate large toxic or side effect.
Drawings
FIG. 1 is a schematic flow chart of a method for preparing nano lysozyme multivitamin provided by the embodiment of the present application.
Detailed Description
In order to make the objects, technical solutions and advantages of the present invention more apparent, embodiments of the present invention will be described in detail with reference to the accompanying drawings.
The invention provides a nano lysozyme multi-vitamin which comprises the following components: the milk replacer comprises, by weight, 5-15 parts of protein powder, 2-10 parts of synthetic collagen powder, 1-3 parts of chitosan, 1-5 parts of taurine, 0.1-0.8 part of shark chondroitin, 1.5-3.5 parts of amino acid derivatives, 1-4 parts of compound amino acids, 0.5-3.5 parts of carotene, 0.5-1.5 parts of vitamin B1, 0.5-1.5 parts of vitamin B2, 0.5-1.5 parts of vitamin B5, 0.5-1.5 parts of vitamin C, 2-10 parts of spirulina powder, 2-8 parts of cooked soybean powder, 0.06-0.16 part of mineral calcium, 0.06-0.16 part of phosphorus, 0.06-0.16 part of magnesium, 0.06-0.16 part of potassium, 0.06-0.16 part of sodium, 0.03-0.14 part of sulfur, 0.03-0.14 part of chlorine, 0.02-0.12.12 parts of selenium, 0.02-0.12 parts of lactobacillus powder and 0.02-1.12 parts of small molecular weight of iodine.
Wherein the small molecule active peptide powder is one or more of soybean peptide powder, corn peptide powder, walnut peptide powder, pea peptide powder, mung bean peptide powder, wheat peptide powder and rice peptide powder. The lactobacillus is one or more of lactobacillus plantarum, lactobacillus salivarius and lactobacillus johnsonii.
Protein is a main component of human body and a main substance in human body life activity, and if measured from life activity process, protein plus nucleic acid is a main form of life existence, and lack of protein can be fatal. Shark chondroitin can activate antibody production in vivo, activate lymphomacrophage, enhance immunity, and delay aging.
Taurine is an active substance for regulating normal physiological activities of organisms, and has a wide range of biological functions of diminishing inflammation, easing pain, maintaining the osmotic pressure balance of the organisms, maintaining the normal visual function, regulating the calcium balance of cells, reducing blood sugar, regulating nerve conduction, participating in endocrine activities, regulating lipid digestion and absorption, increasing the heart contractility, improving the immunity of the organisms, enhancing the oxidation resistance of cell membranes, protecting cardiac muscle cells and the like.
The chemical structure of the chitosan contains active free amino, and the amino group on the sugar chain is combined with H to form a strong positive charge ion group after being dissolved in acid, thereby being beneficial to improving acidic constitution, strengthening the immunologic function of human bodies, removing harmful substances in the bodies and the like, and maintaining the normal pH of the organisms. The chitosan has fusion with human cells, so that the chitosan has various biological activities and biocompatibility. It has been found that chito-oligosaccharide has physiological function of anti-tumor, can be absorbed by human body, is growth factor of bifidobacterium in intestinal tract, and has the effect of promoting the absorption of antibiotics such as tetracycline, aureomycin, etc. by blood, and is beneficial to human body.
Carotene has effects of suppressing immunoreaction of immunocompetent cells, quenching peroxide causing immunosuppression, maintaining fluid fluidity of membrane, maintaining membrane receptor state necessary for immunologic function, and releasing immunoregulatory molecule. The spirulina powder can be classified into feed grade, food grade, special purpose, etc. The feed-grade spirulina powder can be used for aquaculture and livestock breeding, and the food-grade spirulina powder is used for health food and added into other foods for people to eat. The cooked soybean powder is powder prepared by frying and grinding soybeans, and the contained unsaturated fatty acid and soybean lecithin can increase the elasticity of blood vessels and prevent the blood vessels from being broken due to the aging of the blood vessels; the cooked soybean powder contains dietary fiber which can increase satiety of human body and promote defecation, and contains high-quality vegetable protein which can supplement amino acid required by human body.
Amino acids, which are compounds in which the hydrogen atom of a carboxylic acid carbon atom is replaced with an amino group, contain two functional groups, amino and carboxyl groups, and like hydroxy acids, amino acids can be classified into α -, β -, γ -. w-amino acids according to the positions of the amino group attached to the carbon chain, but the amino acids obtained by proteolysis are α -amino acids, and only twenty are these amino acids, which are the basic units constituting proteins.
Minerals are compounds or natural elements naturally occurring in the crust of the earth. Also called inorganic salt, is a general term for inorganic substances in human and animals. Is a general term for various elements which are necessary for forming tissues of human bodies and animals and maintaining normal physiological functions, and is one of seven essential nutrients for human bodies and animals. Minerals, like vitamins, are essential elements for the human body.
The lactobacillus has the effects of regulating intestinal flora, enhancing immunity, protecting gastric mucosa, improving intestinal function, relaxing bowels, preventing and treating diarrhea, promoting digestion, resisting tumor, and resisting oxidation; the small molecular active peptide powder can improve digestive system and enhance immunity.
Viruses are the same mechanisms as human cells, without cell walls. The virus can survive in the animal body, and can die quickly when leaving the body of the host, so the virus cannot be transmitted through air and objects, can be transmitted through droplets in a closed space, and can be infected through oral cavities, respiratory tracts, eyes and a direct entering mode in the body.
Because viruses and human cells are almost the same living environment, the medical community declares that no medical treatment means can kill the viruses at fixed points without damaging the cells of the human body, and the human body with strong immunity can self-heal but not cure the viruses only by resisting and killing the viruses by the immune system of the human body without taking medicines and rescues once the viruses are infected.
Vaccines are the best means of combating the virus, but also require the coordinated completion of the own immune system to be effective. On one hand, the antiviral nano lysozyme multivitamin supplements nutrients and mineral substances required by a human body through eating, and enhances the immunity of the human body; on the other hand, after the multi-vitamin enters a human body digestive system, the digestive system is promoted to be cultured to generate a large amount of nano lysozyme, the nano lysozyme is easy to combine with viruses due to the sticky sugar characteristic, and then the nano lysozyme replaces human body healthy cells to become new hosts of the viruses, and finally the reproduction of the viruses in the human body healthy cells is inhibited, and the multi-vitamin has good inhibiting effect on novel coronavirus through early clinical experiments. In addition, the antiviral food multivitamin is different from chemical or biological medicines, belongs to food medicines, has good safety and does not generate large toxic or side effect.
The antiviral mechanism of the nano lysozyme is as follows: the cell surface infected by the virus has polysaccharide or monosaccharide chains, the nano lysozyme is attached to the polysaccharide chains in a favorite way, namely the nano lysozyme can identify the cell infected by the virus, and in addition, the nano lysozyme can form a composite salt with DNA, RNA and apoprotein in healthy cells, so that the virus is inactivated, and the antiviral effect is achieved.
Further, the nano lysozyme multi-vitamin comprises the following components: 8-14 parts of protein powder, 3-6 parts of synthetic collagen powder, 1.5-2.5 parts of chitosan, 2-4 parts of taurine, 0.2-0.5 part of shark chondroitin, 1.6-2.2 parts of amino acid derivatives, 1.2-3 parts of compound amino acids, 1-2.5 parts of carotene, 0.6-1.3 parts of vitamin B1, 0.6-1.3 parts of vitamin B2, 0.6-1.3 parts of vitamin B5, 0.6-1.3 parts of vitamin C, 3.5-6.5 parts of spirulina powder, 2-5 parts of cooked soybean powder, 0.08-0.12 part of mineral calcium, 0.08-0.12 part of phosphorus, 0.08-0.12 part of magnesium, 0.08-0.12 part of potassium, 0.08-0.12 part of sodium, 0.05-0.13 part of sulfur, 0.05-0.05 part of chlorine, 0.05-0.13 part of magnesium, 0.08-0.12 part of magnesium, 0.03-0.12 part of small molecular selenium, 11-1.11 parts of lactobacillus powder and 11-1.5 parts of small molecular iodine.
As a first preferred embodiment, the nano lysozyme multi-vitamin comprises the following components: by weight, 9 parts of protein powder, 3.5 parts of synthetic collagen powder, 1.6 parts of chitosan, 2.5 parts of taurine, 0.3 part of shark chondroitin, 1.8 parts of amino acid derivatives, 1.4 parts of compound amino acids, 1.5 parts of carotene, 0.7 part of vitamin B1, 0.7 part of vitamin B2, 0.7 part of vitamin B5, 0.7 part of vitamin C, 4 parts of spirulina powder, 2.5 parts of cooked soybean powder, 0.09 part of mineral calcium, 0.09 part of phosphorus, 0.09 part of magnesium, 0.09 part of potassium, 0.09 part of sodium, 0.06 part of sulfur, 0.06 part of chlorine, 0.05 part of selenium, 0.05 part of iodine, 0.05 part of chromium, 1.6 parts of micromolecular active peptide powder and 1 part of lactobacillus.
As a second preferred embodiment, the nano lysozyme multi-vitamin comprises the following components: the feed comprises, by weight, 10 parts of protein powder, 5 parts of synthetic collagen powder, 2 parts of chitosan, 3 parts of taurine, 0.5 part of shark chondroitin, 2 parts of amino acid derivatives, 2 parts of compound amino acids, 2 parts of carotene, 1 part of vitamin B1, 1 part of vitamin B2, 1 part of vitamin B5, 1 part of vitamin C, 5 parts of spirulina powder, 3 parts of cooked soybean powder, 0.1 part of each of mineral calcium, phosphorus, magnesium, potassium, sodium, sulfur, chlorine, selenium, iodine and chromium, 2 parts of small molecular active peptide powder and 1.2 parts of lactobacillus.
As a third preferred embodiment, the nano lysozyme multi-vitamin comprises the following components: the feed comprises, by weight, 12 parts of protein powder, 5 parts of synthetic collagen powder, 2.2 parts of chitosan, 3.5 parts of taurine, 0.4 part of shark chondroitin, 2.1 parts of amino acid derivatives, 2.5 parts of compound amino acids, 2.3 parts of carotene, 1.2 parts of vitamin B1, 1.2 parts of vitamin B2, 1.2 parts of vitamin B5, 1.2 parts of vitamin C, 6 parts of spirulina powder, 5 parts of cooked soybean powder, 0.12 part of mineral calcium, 0.12 part of phosphorus, 0.12 part of magnesium, 0.12 part of potassium, 0.12 part of sodium, 0.11 part of sulfur, 0.11 part of chlorine, 0.08 part of selenium, 0.08 part of iodine, 0.08 part of chromium, 2.5 parts of small molecule active peptide powder and 1.4 parts of lactobacillus.
Based on the same inventive concept, the application also provides a preparation method of the nano lysozyme multi-vitamin, which is shown in the attached figure 1 and comprises the following steps:
s1: mixing and stirring protein powder, synthetic collagen powder, chitosan, taurine, shark chondroitin, amino acid derivatives, compound amino acids, carotene, vitamin B1, vitamin B2, vitamin B5, vitamin C, spirulina powder, cooked soybean powder, mineral calcium, phosphorus, magnesium, potassium, sodium, sulfur, chlorine, selenium, iodine and chromium in a set ratio to uniformly form a first mixture;
s2: adding the first mixture into purified water for grinding to obtain a first-grade semi-finished product;
s3: spray drying the primary semi-finished product to obtain a secondary semi-finished product;
s4: and mixing the secondary semi-finished product with the small molecular active peptide powder and the lactobacillus, and stirring to obtain a finished product of the nano lysozyme multivitamin.
As a preferred embodiment, the preparation method comprises the following steps:
s1: adding protein powder, synthetic collagen powder, chitosan, taurine, shark chondroitin, amino acid derivatives, compound amino acids, carotene, vitamin B1, vitamin B2, vitamin B5, vitamin C, spirulina powder, cooked soybean powder, mineral calcium, phosphorus, magnesium, potassium, sodium, sulfur, chlorine, selenium, iodine and chromium in a stirring tank for first stirring, and uniformly stirring to form a first mixture;
s2: placing the first mixture into a sand mill, adding purified water, and grinding to obtain a first-grade semi-finished product;
s3: placing the primary semi-finished product in spray drying equipment for spray drying to obtain a secondary semi-finished product;
s4: and adding the secondary semi-finished product, the micromolecular active peptide powder and the lactobacillus into a stirring tank for secondary stirring, and forming a finished product of the nano lysozyme multivitamin after uniform stirring.
Further, the first stirring time is controlled to be 12-25 minutes; the grinding time is controlled to be 72-90 minutes; the time of the second stirring is controlled to be 30-45 minutes. As a preferred example, the time of the first stirring is controlled to be 15 minutes; the grinding time is controlled to be 84 minutes; the time of the second stirring was controlled to 30 minutes.
Further, in the first stirring process, the stirring speed is controlled to be 1000 revolutions per minute; in the second stirring process, the stirring speed is controlled to be 120 revolutions per minute; in step S2, the amount of purified water is 500 to 800 parts by weight.
The preparation method of the nano lysozyme multivitamin is described in detail by the following specific examples, and all the raw materials are calculated by weight parts:
example 1
S1: adding 9 parts of protein powder, 3.5 parts of synthetic collagen powder, 1.6 parts of chitosan, 2.5 parts of taurine, 0.3 part of shark chondroitin, 1.8 parts of amino acid derivatives, 1.4 parts of compound amino acids, 1.5 parts of carotene, 0.7 part of vitamin B1, 0.7 part of vitamin B2, 0.7 part of vitamin B5, 0.7 part of vitamin C, 4 parts of spirulina powder, 2.5 parts of cooked soybean powder, 0.09 part of mineral calcium, 0.09 part of phosphorus, 0.09 part of magnesium, 0.09 part of potassium, 0.09 part of sodium, 0.06 part of sulfur, 0.06 part of chlorine, 0.05 part of selenium, 0.05 part of iodine and 0.05 part of chromium into a high-speed stirring tank, stirring for 15 minutes at a speed of 1000 revolutions per minute, and uniformly forming a first mixture;
s2: placing the first mixture into a sand mill, adding 600 parts of purified water for grinding to obtain a first-grade semi-finished product with the granularity of 100 nanometers; the grinding time is controlled to be 84 minutes;
s3: placing the primary semi-finished product in spray drying equipment for spray drying to obtain a secondary semi-finished product;
s4: and adding the secondary semi-finished product, 1.6 parts of micromolecular active peptide powder and 1 part of lactobacillus into a stirring tank for secondary stirring at the rotating speed of 120 revolutions per minute for 30 minutes, and forming a finished product of the nano lysozyme multivitamin after the mixture is uniform.
Example 2
S1: adding 10 parts of protein powder, 5 parts of synthetic collagen powder, 2 parts of chitosan, 3 parts of taurine, 0.5 part of shark chondroitin, 2 parts of amino acid derivatives, 2 parts of compound amino acids, 2 parts of carotene, 1 part of vitamin B1, 1 part of vitamin B2, 1 part of vitamin B5, 1 part of vitamin C, 5 parts of spirulina powder, 3 parts of cooked soybean powder, 0.1 part of mineral calcium, 0.1 part of phosphorus, 0.1 part of magnesium, 0.1 part of potassium, 0.1 part of sodium, 0.1 part of sulfur, 0.1 part of chlorine, 0.1 part of selenium, 0.1 part of iodine and 0.1 part of chromium into a high-speed stirring tank, stirring for 15 minutes at a speed of 1000 revolutions per minute, and uniformly forming a first mixture;
s2: placing the first mixture into a sand mill, adding 600 parts of purified water for grinding to obtain a first-grade semi-finished product with the granularity of 100 nanometers; the grinding time is controlled to be 84 minutes;
s3: placing the primary semi-finished product in spray drying equipment for spray drying to obtain a secondary semi-finished product;
s4: and adding the secondary semi-finished product, 2 parts of micromolecular active peptide powder and 1.2 parts of lactobacillus into a stirring tank for secondary stirring at the rotating speed of 120 revolutions per minute for 30 minutes, and forming a finished product of the nano lysozyme multivitamin after the mixture is uniform.
Example 3
S1: adding 12 parts of protein powder, 5 parts of synthetic collagen powder, 2.2 parts of chitosan, 3.5 parts of taurine, 0.4 part of shark chondroitin, 2.1 parts of amino acid derivatives, 2.5 parts of compound amino acids, 2.3 parts of carotene, 1.2 parts of vitamin B1, 1.2 parts of vitamin B2, 1.2 parts of vitamin B5, 1.2 parts of vitamin C, 6 parts of spirulina powder, 5 parts of cooked soybean powder, 0.12 part of mineral calcium, 0.12 part of phosphorus, 0.12 part of magnesium, 0.12 part of potassium, 0.12 part of sodium, 0.11 part of sulfur, 0.11 part of chlorine, 0.08 part of selenium, 0.08 part of iodine and 0.08 part of chromium into a high-speed stirring tank, stirring for 15 minutes at a speed of 1000 revolutions per minute, and uniformly mixing to form a first mixture;
s2: placing the first mixture into a sand mill, adding 600 parts of purified water for grinding to obtain a first-grade semi-finished product with the granularity of 100 nanometers; the grinding time is controlled to be 84 minutes;
s3: placing the primary semi-finished product in spray drying equipment for spray drying to obtain a secondary semi-finished product;
s4: and adding the secondary semi-finished product, 2.5 parts of micromolecular active peptide powder and 1.4 parts of lactobacillus into a stirring tank for secondary stirring at the rotating speed of 120 revolutions per minute for 30 minutes, and forming a finished product of the nano lysozyme multivitamin after the mixture is uniform.
The above-mentioned embodiments, objects, technical solutions and advantages of the present invention are further described in detail, it should be understood that the above-mentioned embodiments are only illustrative of the present invention and are not intended to limit the present invention, and any modifications, equivalents, improvements and the like made within the spirit and principle of the present invention should be included in the protection scope of the present invention.

Claims (10)

1. The nano lysozyme multivitamin is characterized by comprising the following components: the milk replacer comprises, by weight, 5-15 parts of protein powder, 2-10 parts of synthetic collagen powder, 1-3 parts of chitosan, 1-5 parts of taurine, 0.1-0.8 part of shark chondroitin, 1.5-3.5 parts of amino acid derivatives, 1-4 parts of compound amino acids, 0.5-3.5 parts of carotene, 0.5-1.5 parts of vitamin B1, 0.5-1.5 parts of vitamin B2, 0.5-1.5 parts of vitamin B5, 0.5-1.5 parts of vitamin C, 2-10 parts of spirulina powder, 2-8 parts of cooked soybean powder, 0.06-0.16 part of mineral calcium, 0.06-0.16 part of phosphorus, 0.06-0.16 part of magnesium, 0.06-0.16 part of potassium, 0.06-0.16 part of sodium, 0.03-0.14 part of sulfur, 0.03-0.14 part of chlorine, 0.02-0.12.12 parts of selenium, 0.02-0.12 parts of lactobacillus powder and 0.02-1.12 parts of small molecular weight of iodine.
2. The nano lysozyme multivitamin of claim 1, wherein the small molecule active peptide powder is one or a combination of more of soybean peptide powder, corn peptide powder, walnut peptide powder, pea peptide powder, mung bean peptide powder, wheat peptide powder and rice peptide powder.
3. The nano lysozyme multivitamin of claim 1, wherein the lactobacillus is one or a combination of lactobacillus plantarum, lactobacillus salivarius, lactobacillus johnsonii.
4. The nano lysozyme multivitamin of claim 1, comprising the following components: 8-14 parts of protein powder, 3-6 parts of synthetic collagen powder, 1.5-2.5 parts of chitosan, 2-4 parts of taurine, 0.2-0.5 part of shark chondroitin, 1.6-2.2 parts of amino acid derivatives, 1.2-3 parts of compound amino acids, 1-2.5 parts of carotene, 0.6-1.3 parts of vitamin B1, 0.6-1.3 parts of vitamin B2, 0.6-1.3 parts of vitamin B5, 0.6-1.3 parts of vitamin C, 3.5-6.5 parts of spirulina powder, 2-5 parts of cooked soybean powder, 0.08-0.12 part of mineral calcium, 0.08-0.12 part of phosphorus, 0.08-0.12 part of magnesium, 0.08-0.12 part of potassium, 0.08-0.12 part of sodium, 0.05-0.13 part of sulfur, 0.05-0.05 part of chlorine, 0.05-0.13 part of magnesium, 0.08-0.12 part of magnesium, 0.03-0.12 part of small molecular selenium, 11-1.11 parts of lactobacillus powder and 11-1.5 parts of small molecular iodine.
5. The nano lysozyme multivitamin of claim 4, comprising the following components: the feed comprises, by weight, 10 parts of protein powder, 5 parts of synthetic collagen powder, 2 parts of chitosan, 3 parts of taurine, 0.5 part of shark chondroitin, 2 parts of amino acid derivatives, 2 parts of compound amino acids, 2 parts of carotene, 1 part of vitamin B1, 1 part of vitamin B2, 1 part of vitamin B5, 1 part of vitamin C, 5 parts of spirulina powder, 3 parts of cooked soybean powder, 0.1 part of each of mineral calcium, phosphorus, magnesium, potassium, sodium, sulfur, chlorine, selenium, iodine and chromium, 2 parts of small molecular active peptide powder and 1.2 parts of lactobacillus.
6. A method for preparing nano lysozyme multivitamin of any one of claims 1 to 5, characterized by comprising the following steps:
mixing and stirring the protein powder, the synthetic collagen powder, the chitosan, the taurine, the shark chondroitin, the amino acid derivatives, the compound amino acid, the carotene, the vitamin B1, the vitamin B2, the vitamin B5, the vitamin C, the spirulina powder, the cooked soybean powder, the mineral calcium, the phosphorus, the magnesium, the potassium, the sodium, the sulfur, the chlorine, the selenium, the iodine and the chromium in a set ratio to uniformly form a first mixture;
adding the first mixture into purified water for grinding to obtain a first-grade semi-finished product;
spray drying the primary semi-finished product to obtain a secondary semi-finished product;
and mixing the secondary semi-finished product with the micromolecular active peptide powder and the lactobacillus, and stirring to obtain a finished product of the nano lysozyme multivitamin after the mixture is uniform.
7. The method for preparing nano lysozyme multivitamin of claim 6, wherein the lysozyme is a natural or synthetic natural fiber,
adding the protein powder, the synthetic collagen powder, the chitosan, the taurine, the shark chondroitin, the amino acid derivatives, the compound amino acids, the carotene, the vitamin B1, the vitamin B2, the vitamin B5, the vitamin C, the spirulina powder, the cooked soybean powder, the mineral calcium, the phosphorus, the magnesium, the potassium, the sodium, the sulfur, the chlorine, the selenium, the iodine and the chromium in a stirring tank according to a set proportion for first stirring, and forming a first mixture after uniform stirring;
placing the first mixture into a sand mill, adding the first mixture into the purified water, and grinding to obtain a first-grade semi-finished product;
placing the primary semi-finished product in spray drying equipment for spray drying to obtain a secondary semi-finished product;
and adding the secondary semi-finished product, the micromolecule active peptide powder and the lactobacillus into a stirring tank for secondary stirring, and forming a finished product of the nano lysozyme multivitamin after the mixture is uniform.
8. The method for preparing nano lysozyme multivitamin of claim 7, wherein the lysozyme is a natural or synthetic natural fiber,
the first stirring time is controlled to be 12-25 minutes;
the grinding time is controlled to be 72-90 minutes;
and the time of the second stirring is controlled to be 30-45 minutes.
9. The method for preparing nano lysozyme multivitamin of claim 8, wherein the lysozyme is a natural or synthetic natural fiber,
the time of the first stirring is controlled to be 15 minutes;
the grinding time is controlled to be 84 minutes;
the time of the second stirring was controlled to be 30 minutes.
10. The method for preparing nano lysozyme multivitamin of claim 7, wherein the lysozyme is a natural or synthetic natural fiber,
in the first stirring process, the stirring speed is controlled to be 1000 revolutions per minute;
in the second stirring process, the stirring speed is controlled to be 120 revolutions per minute;
the pure water is added in an amount of 500-800 parts by weight.
CN202010099979.8A 2020-02-18 2020-02-18 Nano lysozyme multivitamin and preparation method thereof Withdrawn CN111280451A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN202010099979.8A CN111280451A (en) 2020-02-18 2020-02-18 Nano lysozyme multivitamin and preparation method thereof

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN202010099979.8A CN111280451A (en) 2020-02-18 2020-02-18 Nano lysozyme multivitamin and preparation method thereof

Publications (1)

Publication Number Publication Date
CN111280451A true CN111280451A (en) 2020-06-16

Family

ID=71017975

Family Applications (1)

Application Number Title Priority Date Filing Date
CN202010099979.8A Withdrawn CN111280451A (en) 2020-02-18 2020-02-18 Nano lysozyme multivitamin and preparation method thereof

Country Status (1)

Country Link
CN (1) CN111280451A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114271475A (en) * 2021-11-10 2022-04-05 湖南紫气新伊智能科技集团有限公司 Biological technology nutrition element system for resisting oxidation and improving human immunity

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114271475A (en) * 2021-11-10 2022-04-05 湖南紫气新伊智能科技集团有限公司 Biological technology nutrition element system for resisting oxidation and improving human immunity

Similar Documents

Publication Publication Date Title
Elala et al. Eubiotic effect of a dietary acidifier (potassium diformate) on the health status of cultured Oreochromis niloticus
Kotrbáček et al. The chlorococcalean alga Chlorella in animal nutrition: a review
Lee Dietary nutrients, additives and fish health
Khora Marine fish-derived bioactive peptides and proteins for human therapeutics
Ghaeni et al. Review for application and medicine effects of Spirulina, microalgae
ES2523984T3 (en) Canine probiotic pseudolongum bifidobacteria
Kiadaliri et al. Effects of feeding with red algae (Laurencia caspica) hydroalcoholic extract on antioxidant defense, immune responses, and immune gene expression of kidney in rainbow trout (Oncorhynchus mykiss) infected with Aeromonas hydrophila
MXPA02011595A (en) Novel probiotics for pet food applications.
JP2015142566A (en) Feed for fish breeding
CN105410365B (en) A kind of feed addictive of alternative antibiotic and its application
JP2007054041A (en) Chicken farming feed and egg
CN106858595A (en) One kind burn tailored version clinical nutrition formula and preparation method thereof
AU2020408413B2 (en) Pet food compositions
Ashida et al. Immunostimulatory effects of fermented vegetable product on the non-specific immunity of Japanese flounder Paralichthys olivaceus
KR102430901B1 (en) Nutritional snack for companion animals containing dried powder of militaris cordyceps grown using edible insects as a medium
KR102650031B1 (en) Composition for improving companion animal heart function and functional food containing the same
CN111280451A (en) Nano lysozyme multivitamin and preparation method thereof
Gumbo et al. A Review: Spirulina a source of bioactive compounds and nutrition
CN116076728B (en) Composition for promoting growth of bifidobacteria
KR20080037457A (en) Compositions for addition to feed for fish comprising bacillus polyfermenticus, bacillus licheniformis and saccharomyces serevisiae
CN105558435A (en) Feed additive for preventing and treating silver carp hemorrhagic disease
KR101600669B1 (en) - A feed additive for improving meat quality comprising -glucan and kefir as an effective ingredient a feed composition and a breeding method using the same
CA2607267A1 (en) Health food and pharmaceutical composition for amelioration of disease induced by metabolic disorder in cartilage
Idoui et al. Effects of autochthonous probiotic feeding on performances, carcass traits, serum composition and faecal microflora of broiler chickens
Makała Impact of Selected Feed Additives in Broiler Nutrition on Breeding and the Meat Quality Features

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination
WW01 Invention patent application withdrawn after publication
WW01 Invention patent application withdrawn after publication

Application publication date: 20200616